Lipopolysaccharide affects NFKBIA

1 | 4 196

Lipopolysaccharide inhibits NFKBIA. 199 / 199

1 | 4 194

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"Another study has shown EGCG to inhibit LPS induced IkappaBalpha degradation, NF-kappaB nuclear translocation, and NF-kappaB DNA binding activity in bone marrow derived macrophages (BMMs) [XREF_BIBR]."

24678847

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"Compare with the group of LPS induced RAW 264.7 macrophages, LPS induced p-IkappaB-alpha and p-p65 protein binding activity was significantly reduced in cultures treated with CG at dose of 100 muM."

29936264

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"As shown in XREF_FIG, 8f effectively reduced LPS induced IkappaB-alpha degradation at a concentration of 10 microM."

29719375

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"When cells were pre-incubated with TPCK (10 mu m) this LPS mediated degradation of IkappaB-alpha was completely blocked."

9990673

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"Further, LPS induced IkappaBalpha degradation was not affected by acute alcohol consumption indicating an IkappaBalpha independent mechanism, as observed earlier in the in vitro acute alcohol studies."

16433741

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"C also significantly attenuated the amount of LPS induced IkappaB-alpha degradation (p <.05), albeit not to the same degrees as the inhibitors."

24983461

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"First, antecedent exposure of alveolar macrophages to S/R resulted in increased LPS induced IkappaBalpha degradation through activation of upstream signaling, an effect that resulted in increased NF-kappaB translocation and cytokine induced neutrophil chemoattractant gene expression."

20661182

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"FA did not attenuate COX-2 expression at a concentration of 100 muM, however, both genistein and FA15 (10 muM each) did (IR = 69 and 76%, respectively), though each were inactive at 2 muM.We next investigated the suppressive effects of FA15 on LPS and IFN-gamma-induced degradation of IkappaB-alpha."

12175542

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"Our results demonstrated that LPS caused rapid degradation of IkBalpha, while MSS1 gene knockdown significantly reduced IkBalpha degradation in LPS stimulated BV2 microglia (XREF_FIG)."

22629310

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"We found that CIS promotes LPS induced IkappaBalpha degradation and enhances NF-kappaB activity in cholangiocytes."

19592657

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"We found that SC extract attenuated LPS induced IkappaB-alpha degradation as well as nuclear translocation of p65 in BV-2 microglia, indicating that SC extract inhibits iNOS and TNF-alpha gene expression in microglia and may be involved in the inhibition of NF-kappaB activation as a possible mechanism."

25514974

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"We show here that pretreatment of lipopolysaccharide (Salmonella abortus equi, 2.5 mg/kg)-challenged mice with ANP (5 microg/kg iv, 15 min) rapidly inhibits nuclear factor-kappaB activation via inhibition of phosphorylation and degradation of the IkappaB-alpha protein."

17008392

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"In a recent study, Wei et al. [36] revealed that rgcIL-10 (recombinant grass carp IL-10) and rgcTGF-beta1 (recombinant grass carp TGF-beta1) could block LPS induced IkappaBalpha protein degradation in grass carp monocytes and macrophages."

27016401

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"In Western blotting, pretreatment with erdosteine inhibited the IkBalpha degradation induced in RAW 264.7 cells by LPS."

27317418

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"We confirmed these results in primary WT microglia transfected with PKCdelta specific siRNA to show that PKCdelta knockdown attenuated LPS induced IkappaBalpha degradation (XREF_FIG), which is consistent with our findings using PKCdelta deficient microglia."

27151770

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"In contrast, LPS stimulation triggered IkappaBalpha degradation after 1 hr in MMNK-1 cells and this was not impacted by TGFbeta1 cotreatment (XREF_FIG)."

22004089

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"CORM-3 did not influence P. intermedia LPS induced degradation of IkappaB-alpha."

26101061

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"Interestingly, the exposure of non CF HBG cells to P. aeruginosa LPS plus genistein prevented the P. aeruginosa LPS induced degradation of IkappaBalpha in cells."

10433940

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"Thus, poly I induced an increase in nuclear factor kappaB (NF-kappaB) transcriptional activity due to a long-term degradation of inhibitory NF-kappaB (IkappaB) beta while lipopolysaccharide (LPS) induced the degradation of both IkappaBalpha and IkappaBbeta."

16158333

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"A6 inhibited the LPS induced OC differentiation, TNF-alpha production, and IkappaBalpha degradation in the control condition, whereas A6 had no effects on them in the uPA knockdown condition."

28493442

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"WIN-34B significantly inhibited the LPS induced degradation of IkappaB-alpha at a concentration of 100 mug/ml (XREF_FIG A)."

24116274

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"Meanwhile, the most active compounds, 3a (XREF_FIG) and 3c (XREF_FIG), dose-dependently reduced the LPS induced IkappaBalpha degradation, though 3c at 5 muM has no significant effect."

24741294

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"As shown in Figure XREF_FIG, neither a MLK3 inhibitor, K252a nor a JNK inhibitor, SP600125 had any effect on LPS induced IkappaB-alpha degradation or NF-kappaB transcriptional activity."

21194439

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"XREF_BIBR Addition of antioxidants or overexpression of peroxidases in the same stressed cells blocked IkappaBalpha degradation induced by TNF, PMA and LPS."

20716925

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"Heat shock, 1 h before treatment with LPS, completely inhibited LPS mediated degradation of I-kappaBalpha."

11049108

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"To rule out the possibility that this decrease was due to the loss of PP4 's known negative regulation of LPS induced NFkappaB activation XREF_BIBR, we examined LPS induced IkappaBalpha degradation in WT and CD23 cre PP4 F/F B cells but found no abnormalities in the mutant cells (XREF_SUPPLEMENTARY)."

25215539

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"LPS challenge caused IkappaB-alpha degradation in both WT endothelial cells (XREF_SUPPLEMENTARY) and -transfected cav-1 -/- endothelial cells transfected with WT-Cav-1 (XREF_FIG)."

24244013

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"Using Western blot analysis, TPCK was found to actually inhibit LPS mediated degradation of IkappaB-alpha."

9990673

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"UA also inhibited LPS mediated I-kappaBalpha degradation."

19003951

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"We also explored whether blue pigments inhibited the LPS stimulated degradation of IkappaB-alpha in RAW 264.7 cells by Western blotting with anti-IkappaB-alpha antibody."

22479539

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"Stimulation with hMRP8 or LPS caused IkappaBalpha degradation as represented by substantially reduced total IkappaBalpha protein and activated NF-kappaB p65 in naive cells; however, pre-stimulation with hMrp8 failed to prevent hMrp8- or LPS induced IkappaBalpha degradation (XREF_FIG) and NF-kappaB p65 phosphorylation (XREF_FIG)."

26329314

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"In lean subjects, LPS induced IkBalpha activation was not significant compared to unstimulated control myotubes, whereas PMI 5011 mediated inhibition of LPS induced activation of IkBalpha was significant."

24521217

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"In addition, we found that AMPK negatively regulated LPS induced IkappaB-alpha degradation and positively regulated Akt activation, accompanied by inhibition of GSK3-beta and activation of CREB."

19050283

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"The specificity of this effect was again indicated by the lack of IkappaBalpha degradation in cells treated with the LPS contamination control (XREF_FIG, lane 3)."

21094186

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"These data indicated that gene silencing of C5aR with siRNA protected from LPS induced NF-kappaB activation and nuclear translocation.To clarify whether the C5aR effect on NF-kappaB nuclear translocation is due to the regulation of the NF-kappaB inhibitor IkappaBalpha, we transfected endothelial cells with C5aR-siRNA and then added LPS for different times to follow LPS induced IkappaBalpha degradation."

20138669

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"DEX prevented the LPS induced IkappaBalpha degradation, which was also reversed by exogenous PAF."

10229101

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"Moreover, LPS treatment caused prominent IkappaB-alpha degradation as compared to the untreated control cells; nevertheless, PEF pretreatment notably recovered the protein level of IkappaB-alpha (XREF_FIG)."

30159118

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"As expected 3, robust LPS induced I-kappaBalpha degradation and activation of IKK and ERK were observed in naive macrophages but strongly blunted in TNF tolerized macrophages (XREF_FIG)."

28825701

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"In contrast to LPS tolerized cells, in TNF tolerized macrophages the initial phase of LPS induced I-kappaBalpha degradation was nearly intact (XREF_FIG, lanes 9-12 vs. 5-8)."

21602809

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"1,8-Cineole and rosiglitazone blocked the LPS induced IkappaBalpha degradation and NF-kappaB p65 nucleus translocation, which could be reversed by the pretreatment of GW9662 or silence of PPAR-gamma gene."

30930772

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"LPS induced IkappaBalpha degradation in control cells as early as 20 min but in co-treated cultures the degradation of IkappaBalpha was not evident."

24020912

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"Furthermore, RP-L blocked LPS induced degradation of IkappaB-alpha and nuclear accumulation of p65."

31907559

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"This crude drug decreased LPS induced IkappaBalpha degradation in a concentration dependent manner without affecting LPS induced IkappaB phosphorylation."

16006736

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"Furthermore, the compound inhibited LPS mediated nuclear translocation of NF-kappaB p65 and DNA binding activity of NF and kappaB complex, in parallel, but did not influence LPS mediated IkappaBalpha degradation."

15896337

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"The experimental evidence obtained in RAW 264.7 macrophages indicating that IDR-1002 inhibits LPS induced COX-2 expression, activates CREB phosphorylation at Ser133, and inhibits LPS induced IkappaBalpha degradation was confirmed in PBMC."

27933067

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"Consistent with these findings, FACScan analysis further revealed that hMrp8 pre-stimulation significantly downregulated both hMrp8- and LPS induced p38 phosphorylation, but failed to attenuate hMrp8- or LPS induced IkappaBalpha degradation and NF-kappaB p65 activation."

26329314

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"Both E. coli LPS and P. gingivalis LPS induced IkappaBalpha degradation in human gingival fibroblasts."

26513680

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"Furthermore, LPS induced IkappaBalpha degradation, DNA binding, and NF-kappaB-dependent gene transcription activation were abrogated by short-term heat."

16597688

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"Since TIRAP is reportedly a proximal signaling mediator that functions upstream of IkappaB degradation, the ability of TIRAP-D/N to inhibit LPS induced IkappaBalpha degradation in EC was assayed."

12083783

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"As expected, an almost complete loss of phospho- IkappaBalpha as well as IkappaBalpha was identified in macrophages treated with LPS alone."

23190501

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"These data show that LPS treatment activated NF-kappaB by promoting the degradation of IkappaBalpha and the nuclear localization of NF-kappaBp65, which induced MUC5AC overproduction."

22576247

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"Furthermore, treatment with the PKC inhibitor abrogated LPS induced IkappaBalpha degradation and NF-kappaB activation, while treatment with the PTP inhibitor enhanced LPS induced IkappaBalpha degradation and NF-kappaB activation in p-AMs, suggesting that PKC and PTP are regulators of LPS induced IkappaBalpha degradation and NF-kappaB activation."

24209633

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"LPS induced IkappaBalpha degradation greatly varied over time, whereas that induced by TGF-alpha gradually increased to reach maximal levels after 1 h of stimulation after which IkappaBalpha expression increased."

20685965

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"LPS treatment of B cells triggers the rapid degradation of IkappaBalpha followed by the nuclear translocation of cytoplasmic p50-RelA and p50-c-Rel heterodimers, both in 70Z/3 and primary splenic B cells."

19710460

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"Effect of quercetin on P. intermedia LPS induced IkappaB-alpha degradation."

24040572

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"Thus, poly I induced an increase in nuclear factor kappaB (NF-kappaB) transcriptional activity due to a long-term degradation of inhibitory NF-kappaB (IkappaB) beta while lipopolysaccharide (LPS) induced the degradation of both IkappaBalpha and IkappaBbeta."

16158333

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"Figure 3A and B show that LPS dramatically stimulated IkappaB-alpha degradation by 30 min after the start of treatment and that this degradation was clearly inhibited by the bis -eugenol treatment."

12963494

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"In addition, it was reported that PHOX inhibitors prevented LPS and IFNgamma induced degradation of IkappaBalpha, and thus, inhibited the activation of NF-kappaB."

18566433

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"In addition, the ability of EGL to block the LPS stimulated degradation of IkappaB-alpha was investigated by western blotting."

23408713

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"Besides, CDM did not affect the kinetic of IkappaBalpha degradation induced by LPS."

19162100

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"In addition, in vitro LPS stimulation (50 microg ml (-1)) significantly induced NF-kappaB activation and cytoplasmic IkappaBalpha degradation in Mphi, enhanced TNF-alpha mRNA levels and increased Mphi TNF-alpha and MAL."

12031715

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"Degradation of I-kappaBalpha by LPS was significantly abolished in cells pretreated with arctigenin at the concentration of 1 muM."

11789661

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"Furthermore, CHL partially restored LPS decreased IkappaBalpha, an inhibitory protein against NF-kappaB activation, in the cytosolic extract from the LPS treated cells determined by immunoblot analysis."

10896853

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"Next, we investigated whether genistein inhibits LPS induced degradation of IkappaB-alpha in RAW 264.7 macrophages by Western blotting with anti-IkappaB-alpha antibody."

23300870

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"As expected, IkappaBalpha degradation was observed at 15 and 30 minutes in cells treated with LPS (XREF_FIG, lanes 2 and 3); however there was no significant effect of Misoprostol on the rate or the level of IkappaBalpha degradation (XREF_FIG; compare lanes 2, 3 and 6, 7)."

26408955

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"In the present study, using murine macrophages, we clearly demonstrate that erucin inhibits LPS induced degradation of IkappaB-alpha, translocation of p65 from the cytosol to nucleus and NFkappaB DNA biding activity and NFkappaB reporter activity (XREF_FIG)."

24132147

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"In the present study, we observed that LPS challenge induced the degradation of IkappaB-alpha and activation of NF-kappaB in vitro, and the activation of NF-kappaB signaling was further elevated by ERRalpha knockdown, suggesting that activation of NF-kappaB signaling plays an important role in the deteriorative effects of ERRalpha knockdown on ALI."

32714486

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"The extract also inhibited LPS induced IkappaBalpha degradation and MAPK activation as well as LPS and IFN-gamma-induced STAT1 activation, effects observed at a higher concentration than that required to suppress iNOS."

21354293

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"LPS induced IkappaBalpha degradation and increased levels of NF-kappaB p65 subunit in the nucleus."

23199346

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"In our study, LPS induced degradation of IkappaB-alpha and NF-kappaBp65 nuclear localization in BMDCs from Wnt5aCAGDelta and Delta and Ror2 MxDelta and Delta mice, as well as BMDCs from control mice."

26030277

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"Exploration of the mechanisms by which GSK-3beta positively regulates inflammatory response showed that LPS induced IkappaB-alpha degradation, NF-kappaBp65 nuclear translocation, and p65 DNA binding activity were not affected by inhibition of GSK-3beta activity."

21194439

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"In addition, it has been reported that PHOX inhibitors prevent LPS and IFNgamma induced degradation of IkappaBalpha, and thus inhibit activation of NF-kappaB [XREF_BIBR]."

18507839

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"Earlier it was shown that in macrophage cell lines, constitutively expressed AMPK reduced LPS stimulated IkappaBalpha (inhibitor of NF-kappaB) degradation and p65 binding to the IL-6 promoter."

32518807

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"LPS also stimulated IkappaBalpha degradation in rBDECs after 1 hr (data not shown)."

22004089

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"CAPE did not interfere with IkappaB-alpha degradation induced by P. intermedia LPS."

25601508

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"Furthermore, E5531 was able to inhibit LPS stimulated IkBalpha degradation at 0.1 mug/ml (XREF_FIG d)."

14517279

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"The incubation of mouse splenocytes with alpha-cubebenoate prior to LPS stimulation markedly blocked LPS induced IkappaB-alpha degradation (XREF_FIG E)."

25541055

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"As shown in XREF_FIG, Shp2 deletion had no effect on LPS stimulation of IkappaBalpha degradation (hence NF-kappaB activaton) in hepatocytes."

21575863

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"Here, we report that knockdown of NEMO by RNA interference in Jurkat E6.1 cells enhanced TCR induced NF-kappaB report gene activity and IL-2 production by promotion of IkappaBalpha degradation and p65 nuclear translocation, whereas inhibited TNF-alpha and LPS induced IkappaBalpha degradation without influencing the phosphorylation of MAPKs."

22513115

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"LPS induced IL-8 production was determined by enzyme linked immunosorbent assay (ELISA), and LPS induced IkappaB-alpha degradation was followed by Western blot analysis."

18607954

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"In the meanwhile, LPS treatment did not induce degradation of IkappaBalpha protein in p38alpha -/- astrocytes (XREF_FIG)."

25502009

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"Consistent with this finding, BE inhibited LPS induced IkappaBalpha degradation, NF-kappaB nuclear translocation, and also Akt, c-Jun NH2-terminal kinase (JNK) phosphorylation."

19815299

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"PYE inhibited LPS induced TNF-alpha and IL-6 in macrophages at the transcriptional level and also suppressed LPS induced IkappaBalpha degradation and MAPK activation in vitro."

24720857

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"Bacterial LPS induced IkappaBalpha degradation in human gingival fibroblasts was investigated by western blot."

26513680

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"Although LPS treatment also induced the degradation of IkappaBalpha, the kinetic pattern was different from that of PCSC."

12946432

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"When added at the same concentration, clasto -lactacystin beta-lactone also inhibited LPS induced degradation of IkappaB-alpha in the CHO-CD14 cells (data not shown)."

9529257

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"However, we observed no change in the kinetics of LPS induced IkappaBalpha degradation in Ptpn22 -/- BMM (XREF_SUPPLEMENTARY)."

23871208

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"In addition, both EGCG and GCG inhibited LPS induced degradation of IkappaBalpha with concomitant inhibition of nuclear protein binding to NF-kappaB site and synthesis of IRF-1."

15340218

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"We also confirmed that A6 attenuated the LPS induced IkappaBalpha degradation."

28493442

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"DBZ suppressed the LPS induced degradation of IkappaBalpha, thereby decreasing the translocation of p65 to nucleus."

22178877

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"However, LPS and LSECtin mAb combined treatment induces IkappaBalpha degradation that last up to 2h."

26943817

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"PPARgamma ligand delayed LPS induced IkappaBalpha degradation."

16614990

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"To address the possibility that the impaired nuclear translocation of p65 was due to inhibition of degradation of IkappaB-alpha, we examined the effect of ATL on IkappaB-alpha degradation induced by LPS."

21831303

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"Similar to these previous findings, we show here that dDAVP inhibited both the LPS induced degradation of IkappaB-alpha and its stimulation of phosphorylated p65 and RelA, as well as LPS mediated NF-kappaB activation and cytokine secretion in mpkCCD cl4 cells."

17967904

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"Degradation of IkappaB-alpha protein by LPS was almost completely abolished in RAW 264.7 cells treated with these compounds at 10 or 30 muM concentrations."

12595079

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"Within 15 min, LPS alone rapidly induced degradation of IkappaBalpha, levels of which returned to normal within 30-5 min."

18404419

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"This occurred at the transcriptional level, since the gingerol compounds decreased LPS induced IkappaB-alpha degradation, prevented nuclear translocation of NF-kappaB p65 and reduced NF-kappaB activity in a concentration dependent manner."

16732525

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"Thus, shRNA against TRPV2 inhibited the LPS induced mRNA for tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL) -6 and induced inhibitor of nuclear factor-kappaB (NF-kappaB) alpha (IkBalpha) degradation."

23420671

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"Interestingly, NFkappaB activation of B lymphocytes by LPS occurs rapidly and is likely initiated by LPS induced IkappaBalpha degradation, which occurs in 1-1.5 hr."

21599461

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"In addition, the 2h P. amarus pretreatment significantly blocked the degradation of LPS induced IkappaBalpha in a concentration dependent manner (Additionalfile2 : Figure S2)."

30045725

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"However, LPS and IFN-gamma-induced degradation of I-kappaBalpha was attenuated in the presence of C-1."

11274976

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"Although the initial IkappaB-alpha degradation induced by LPS was minimally affected by beta-agonists, the latter induced a marked rebound of the cytosolic IkappaB-alpha levels at later time points (> 1 h), accompanied by an increased IkappaB-alpha cytoplasmic half-life."

11000127

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"THC also significantly suppressed LPS induced release of pro inflammatory cytokines and degradation of IkappaB-alpha."

24474616

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"Moreover, CSM and LPS (as a control) degradated IkappaB-alpha and preincubation of MDMs with NAC suppressed the degradation of IkappaB-alpha induced by CSM."

19409098

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"AMWAP prevents LPS triggered degradation of IRAK-1 and IkappaBalpha."

25928566

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"Zn250 also attenuated the LPS induced IkB-alpha degradation."

32417542

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"Besides, LPS induced IkappaBalpha degradation was little affected either (XREF_FIG), indicating that NCTD advanced NF-kappaB activation was not through IkappaBalpha degradation."

22984593

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"Bacterial LPS induces persistent NF-kappaB activation by degrading IkappaB-alpha as well as IkappaB-beta in responsive cells."

9529323

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"15-A 3t -IsoP blocked the LPS stimulated IkappaBalpha degradation both at 15 min as well as at 30 min (XREF_FIG)."

21838782

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"PL has been shown to inhibit LPS induced IkappaBalpha degradation and activation of NF-kappaB and ERK in liver [XREF_BIBR]."

26550019

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"We next determined whether NFD-37 could affect LPS induced IkappaBalpha degradation, using Western immunoblot analysis with cytoplasmic extracts of murine macrophages RAW 264.7."

16644477

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"Conflicting data exists on whether parthenolide inhibits LPS induced IkappaBalpha degradation, while the effect on IkappaBbeta degradation has never been reported."

23418625

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"However, curcumin abolished the LPS induced IkappaBalpha degradation."

11077049

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"CSE or LPS (the positive control) increased IkappaB-alpha phosphorylation (XREF_FIG) and exposure to CSE or LPS resulted in the degradation of IkappaB-alpha (XREF_FIG)."

19293939

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"BHBA was found to inhibit the LPS induced degradation of IkappaB-alpha."

24803746

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"As shown in Fig. 2, 1-BP suppressed the IkappaBalpha degradation induced by IL-1 or LPS in astrocytes without influence on beta-actin."

16815550

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"Western blots revealed that IkappaB-alpha ( NF-kappaB inhibitor alpha ) degraded 1 h after LPS administration and began to restore after 3 h , while TP pretreatment inhibited LPS induced IkappaB-alpha degradation 1 h after LPS injection ( Fig. 4H and L ) ."

32528833

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"In addition, THC significantly attenuated LPS induced degradation of IkappaB-alpha in LPS induced rat mesangial cells."

25091807

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"C also reduced LPS induced IkappaB-alpha degradation and NF-kappaB translocation."

24983461

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"Recently, BAI has been shown to inhibit inflammation through inhibition of COX-2 gene expression [XREF_BIBR] and to suppress LPS induced degradation of IkappaBalpha and activation of NF-kappaB [XREF_BIBR]."

22309647

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"Pretreatment of rats with pyrrolidine dithiocarbamate (50, 100, and 200 mg/kg, i.p.), an inhibitor of NF-kappaB activation, prevented LPS induced I-kappaBalpha degradation and the resultant NF-kappaB activation and inhibited, in a dose related manner, the LPS induced CINC and ICAM-1 mRNA and protein expression."

10101023

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"As shown in Figure 4A XREF_FIG, treatment with LPS induced IkappaBalpha degradation, which was significantly blocked by SFEIO."

27822172

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"It has been shown previously that LPS treatment causes degradation of IkappaBalpha protein within 40 minutes, followed by induction of IkappaBalpha mRNA that results in rapid recovery of the IkappaBalpha protein by 3 hours."

16207380

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"We also confirmed that uPA, plasmin, TFLLRN-NH 2, and AICAR attenuated the LPS induced IkappaBalpha degradation."

26722218

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"This indicates LPS induced IkappaBalpha degradation (XREF_FIG)."

25080336

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"However, these compounds did not prevent the DNA binding activity of NF-kappaB assessed by electrophoretic mobility shift assay as well as the induced degradation of IkappaB-alpha protein by LPS or TNF-alpha."

14599550

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"In order to investigate whether LPS is able to activate NF-kappaB via intracellular TLR4, we examined degradation of IkappaB-alpha in NB-1 cells treated with LPS (100 ng/ml) for various time."

17156435

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"Treatment with flavonoids blocked LPS induced IkBalpha degradation."

28878808

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"In the present study, we found LPS challenge induced the degradation of IkappaB-alpha and activation of NF-kappaB in vivo and in vitro, and the activation of NF-kappaB signaling was inhibited by DPQ treatment, suggesting that inhibition of NF-kappaB signaling plays a role in the protective effects of DPQ on ALI."

24278171

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"We also used western blotting to determine whether SF would block LPS stimulated degradation of IkappaB-alpha."

25574463

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"The present study showed that both LPS administration and the fcHFHS diet decreased hypothalamic NFKBIA protein and increased Nfkbia mRNA."

29760677

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"NCX 2121 did not display inhibitory action towards IkappaB-alpha degradation triggered by LPS."

28822764

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No evidence text available

22363816

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"In addition we have shown that the compound inhibited the LPS and IFN-gamma mediated degradation of the IkappaB-alpha protein and subsequent activation of the NF-kappaB transcription factor."

10908724

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"Misoprostol does not affect LPS induced IkappaBalpha Degradation and NFkappaB Nuclear Translocation."

26408955

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"LPS induced IkappaBalpha degradation (~ 0.4 fold) was recovered in CMCE (1 and 10 mug/mL) pre-treated THP-1 cells in a dose dependent manner (~ 1.8 and 2.3 fold, respectively)."

27504095

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"However, as the precise timing and mechanism of LPS and nigericin activation of the Nalp3 (NLRP3) inflammasome is poorly understood, it is also possible that the lack of activated caspase-1 was due to altered TLR signaling in heat shock conditions, as reflected by heat shock 's inhibitory effect on LPS mediated IkappaB-alpha breakdown (data not shown)."

18671821

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"To confirm degradation of IkappaBalpha by the proteasome, we used the proteasome inhibitor MG-132, which reversed IkappaBalpha degradation in all samples, demonstrating that LPS induced IkappaBalpha degradation was dependent on the proteasome (XREF_FIG)."

29440572

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"Previous studies have shown [XREF_BIBR, XREF_BIBR], cilostazol inhibits proinflammatory factor (including remnant lipoprotein particle, TNFalpha and LPS)-stimulated increases in IkappaBalpha degradation and NF-kappaB p65 activity, and thus, suppresses the productions of inflammatory cytokines."

27977755

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"Aspirin pretreatment also abrogated LPS induced degradation of IkappaBalpha in p-AMs."

24209633

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➶

reach

"Parthenolide inhibits LPS induced IkappaBalpha degradation and NF-kappaB activation in RAW 264.7, peripheral blood mononuclear, and vascular smooth muscle cells."

23418625

---

➶

reach

"Similarly, CyP prevented LPS induced IkappaBalpha degradation and subsequent induction, both indicative of NF-kappaB activation (XREF_FIG)."

16717116

---

➶

reach

"Taken together, these results suggest that BMS-345541 or wortmannin block LPS induced IkappaBalpha degradation."

24020912

---

➶

eidos

"S9 Fig shows that LPS induced a significant reduction in IkappaBalpha that last up to 1h ."

26943817

---

➶

reach

"We also used the LPS induced degradation of IkappaBalpha as a measure of signaling function, as this event does not appear to require tyrosine kinase activity and therefore should be intact."

12810683

---

➶

eidos

"LPS stimulation resulted in significantly increased level of NF-kB p65 phosphorylation and decreased level of IkBa expression in normal PMVECs ."

25644821

---

➶

reach

"However, these effects were significantly reversed by OEA (40muM) at 60min of LPS stimulation, which indicated that OEA inhibited LPS induced IkappaBalpha degradation in THP-1 cells."

27721381

---

➶

reach

"Consistent with our previous data, we found that nanoparticle treatment functioned to attenuate LPS induced I k B-alpha degradation and NF-kB and p65 trans-location from the cytoplasm to the nucleus (XREF_FIG)."

25968464

---

➶

reach

"Emodin inhibited the LPS induced degeneration of I kappaB-alpha by corneal fibroblasts in a dose dependent manner (P < 0.05)."

19968079

---

➶

reach

"LPS caused a significant decrease in both IRAK1 and IkappaBalpha which was not prevented by IV rimonabant."

26298320

---

➶

reach

"Liao et al XREF_BIBR demonstrated that RvD1 can suppress LPS induced IkappaBalpha degradation and NF-kappaB p65 nuclear translocation, a process which is central to the TNF-alpha induced signalling XREF_BIBR."

23840712

---

➶

reach

"Thiacremonone also inhibited LPS induced degradation of IkappaB-alpha (increase phosphorylation) in RAW 264.7 cells."

19788760

---

➶

reach

"In the present study, an analysis of the whole cell extracts showed that the P.g. LPS induced IkappaBalpha degradation in fibroblasts was paralleled by a P.g. LPS induced increase in CatB in the late culture period; furthermore, the P.g. LPS induced IkappaBalpha degradation was prevented by CA-074Me pretreatment (XREF_FIG)."

27648120

---

➶

reach

"In addition, we found that LPS mediated degradation of IkappaBalpha was markedly less pronounced in macrophages that were pre-treated with FtL or apoferritin (XREF_FIG)."

30804939

---

➶

reach

"LPS induced IkappaBalpha Degradation Is Intact in XLA PBMCs."

12810683

---

➶

reach

"As prior BCA (20 muM) treatment effectively prevented LPS induced IkappaBalpha degradation, it is suggested that BCA prevented LPS induced IkappaBalpha degradation and NF-kappaB activation, and decreased iNOS protein expression and NO production.It has been reported that IkappaBalpha protein phosphokinase can phosphorylate IkappaBalpha and thereby target it for degradation through the ubiquitin-proteasome pathway [35]."

11286985

---

➶

reach

"Although LPS diminished AMPK phosphorylation, metformin or AICAR was able to partially decrease the effects of LPS and toll like receptor 4 (TLR4) engagement on downstream signaling events, particularly LPS induced IkappaBalpha degradation."

24091934

---

➶

reach

"Au (III) and Pd (II) enhanced LPS induced IkappaBalpha degradation, but Hg (II) and Ni (II) suppressed it."

15983993

---

➶

reach

"NFD-37 (10 muM) inhibited the LPS induced IkappaBalpha degradation in a time dependent manner."

16644477

---

➶

reach

"While GG6 reduced LPS induced IkappaB-alpha degradation and showed a trend towards reduced interleukin-1beta release, GG9 prevented the increase in proinflammatory CD80 + macrophage subset, downregulation of the anti-inflammatory CD206 + / CD163 + subset, increase in p38 phosphorylation, and increase in cell bound and secreted interleukin-1beta stimulated by LPS, at least in part through signalling pathways not involving Toll like receptor 4 and nuclear factor-kappaB."

29576743

---

➶

reach

"LPS induced IkappaBalpha degradation at 30-60 min after treatment, but did not induce IkappaBbeta degradation up to 120 min."

9743602

---

➶

reach

"To do this, we analyzed MyD88, TRAF6, IKKalpha, IKKbeta, and phospho-IKKalpha and beta (p-IKKalpha and beta), which we found were not affected by infection (XREF_SUPPLEMENTARY), and LPS induced IkappaBalpha degradation (XREF_FIG)."

29440572

---

➶

reach

"(3) LXA (4) restrained LPS induced IkappaBalpha degradation, NF-kappaB translocation, and NF-kappaB transcriptional activity."

17687517

---

➶

reach

"It has been reported that LPS challenge (2 mug/ml) can be used to induce the degradation of I k B-alpha and nuclear localization of NF-kB and p65 in cultured RAW264.7 macrophages [XREF_BIBR, XREF_BIBR]."

25968464

---

➶

reach

"As shown in Figure XREF_FIG, apo-9 '-fucoxanthinone was shown to significantly suppress the LPS induced IkappaB-alpha degradation."

23889890

---

➶

reach

"Results indicated that LPS significantly stimulated the degradation of IkappaB-alpha, which was effectively prevented by osthole pretreatment in a dose dependent manner (XREF_FIG)."

30057486

---

➶

reach

"However, pretreatment with 300mug/ml PS+CR significantly decreased the phosphorylation of I-kappaBalpha and blocked the LPS induced degradation of I-kappaBalpha, suggesting that PS+CR may regulate phosphorylation of I-kappaBalpha and I-kappaBalpha expression."

29351747

---

➶

reach

"Effects of Comp on the Phosphorylation of MAPK and IkappaBalpha, and Degradation of IkappaBalpha by LPS Stimulated BMDCs."

27153074

---

➶

reach

"Both BAY 11-7085 and parthenolide inhibited LPS induced IkappaBalpha and IkappaBbeta degradation in a dose dependent manner (XREF_FIG)."

26342031

---

➶

reach

"As shown in Figure XREF_FIG A LPS plus IFNgamma significantly induced the degradation of IkappaBalpha in cytosol, whereas pretreatment of RSV resulted in prevention of the degradation of IkappaBalpha."

28966618

---

➶

reach

"As shown in Figure XREF_FIG A, LPS induced IkappaB-alpha degradation at 15min after the stimulation."

24962785

---

➶

reach

"CpdA delayed LPS induced IkappaBalpha reduction reaching its minimum at 120min post-stimulation (XREF_FIG)."

27857212

---

➶

reach

"Alcohol did not prevent LPS induced IkappaBalpha degradation but decreased the levels of phospho specific IkappaBalpha (Ser32)."

10545482

---

➶

reach

"LPS and silica both induce degradation of IkappaB-alpha, and MG132 prevents LPS induced, but not silica induced, IkappaB degradation and NF-kappaB activation [63]."

9920280

---

➶

reach

"LPS induced IkappaBalpha degradation results in NFkappaB translocation, DNA binding, and transactivation of target genes such as TNF-alpha."

19561104

---

➶

reach

"LPS induced IkappaBalpha degradation was enhanced in cells expressing WT Fcalpha and muR but not mutated Fcalpha and muR (TM-mt) (XREF_FIG)."

27146354

---

➶

reach

"In contrast substantial I-kappaBalpha degradation was observed in control experiments where the cells were treated with LPS (XREF_SUPPLEMENTARY)."

23552605

---

➶

reach

"As shown in XREF_FIG, compound 20 dose-dependently reversed LPS induced IkappaBalpha degradation."

27118147

---

➶

reach

"This is consistent with the observations that 6-MP did not inhibit IkappaB-alpha degradation induced by LPS."

27075886

---

➶

reach

"To determine whether luteolin interferes with LPS induced IkappaBalpha degradation, the level of IkappaBalpha protein was examined by Western blotting."

12963482

---

➶

reach

"The immunocomplex kinase assay indicated that IkappaB kinase activity stimulated by LPS was inhibited by ceramide, which concomitantly reduced the IkappaBalpha degradation caused by LPS within 1-6 h."

11313375

---

➶

reach

"Thus, we performed Western blotting to determine if TA affects TNF-alpha- or LPS stimulated IkappaB-alpha degradation in different cells."

25593642

---

➶

reach

"In addition, we found that octyl caffeate did not significantly affect IkappaBalpha degradation stimulated by LPS and IFN-gamma in RASMCs."

12694879

---

➶

reach

"CGRP prevented LPS induced IkappaBalpha degradation and NF-kappaB binding to promoters of CXCL1, CXCL8 and CCL2."

21334428

---

➶

reach

"We next examined the effect of CMCE on LPS induced IkappaBalpha degradation in THP-1 cells."

27504095

---

➶

reach

"Immunoblotting showed that carabrol suppressed LPS induced degradation of I-kappaBalpha and decreased nuclear translocation of p65."

20026303

---

➶

reach

"The results showed that LPS stimulation caused degradation of IkappaB-alpha compared with negative control cells (P < 0.05), whereas PF-GPD blocked LPS induced degradation of IkappaB-alpha (P < 0.01), and inhibited NF-kappaB p65 translocation from the cytoplasm to the nucleus, thus interrupting the transcription and translation of inflammatory genes."

29391009

---

➶

reach

"Two hour pretreatment with ZER prevented the degradation of LPS stimulated IkappaBalpha in a concentration dependent manner."

29310107

---

➶

reach

"Additionally, TTN decreased LPS induced IkappaB-alpha degradation (XREF_FIG)."

28817116

---

➶

eidos

"As shown in Figures 6 ( c ) and 6 ( d ) , LPS enhanced the IkappaB-alpha phosphorylation , decreased the levels of IkappaB-alpha , and induced the phosphorylation of p65 ."

32685466

---

➶

reach

"Compounds 1 and 2 suppressed the expression of iNOS and COX-2 and the activity of NF-kappaB through the inhibition of LPS induced I-kappaB-alpha degradation in microglia."

18276135

---

➶

reach

"The degradation of IkappaBalpha was analyzed by western blot, and we observed that the treatment of macrophages with compound 1 prevented the IkappaBalpha degradation induced by LPS stimulation for 15 and 30 min (XREF_FIG)."

24358331

---

➶

reach

"The results showed that treatment of cells with both LPS and dibutyryl cAMP, an analog of cAMP, activated PKA; however, only LPS treatment caused the degradation of IkappaB-alpha and IkappaB-beta."

9150141

---

➶

reach

"LPS treatment of control MDMs reduced IkappaBalpha with a concomitant increase in p-IkappaBalpha (p-IkappaBalpha and IkappaBalpha ratio increased from 0.17 to 0.9)."

22982462

---

➶

reach

"Degradation of I-kappaBalpha protein by LPS was almost completely abolished in the livers of rats pretreated with ACF at the dose of 10 mg/kg."

10963850

---

➶

reach

"We show here that MV and LPS each induced the degradation of IkappaB-alpha, MV enhanced LPS induced IkappaB-alpha degradation."

24058610

---

➶

reach

"To examine the IkappaBalpha degradation, we performed immunocytochemistry on RAW 264.7 macrophages treated with LPS alone or in combination with TDZ for indicated time points."

30127400

---

➶

reach

"As shown in XREF_FIG, LPS stimulation induced the degradation of IkappaB-alpha and activation of NF-kappaB in RAW264.7 cells."

29207037

---

➶

reach

"These results indicate that LPS induces IkappaBalpha degradation by acting at an upstream step to NF-kappaB activation."

24020912

Lipopolysaccharide bound to TLR4 inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"LPS binding to TLR4 induces IkappaB-alpha degradation, which leads to NF-kappaB activation."

23667114

Modified lipopolysaccharide inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"We tested the effect of crocin on nuclear factor-kappa B (NF-kappaB) signaling and observed that cells pre-treated with 500muM of crocin exhibited lower levels of LPS induced p-IkappaBalpha, p-IkappaB kinase (IKK) alpha/beta, and p65 expression than those of untreated cells."

29777367

SB 203580 affects MAPK14

4 54 | 2 44 5 13

SB 203580 inhibits MAPK14. 122 / 122

4 54 | 2 44 5 13

---

➶

tas

No evidence text available

12672248

---

➶

medscan

"The inhibition of the glucose transporter GLUT1 by phloretin notably reduces TXNIP RNA level and the inhibition of the p38 MAP kinase activity by SB203580 reverses the effects of TXNIP on reactive oxygen species-TRX activity."

17555594

---

➶

medscan

"Selective inhibition of p38mitogen-activated protein kinase activity by SB203580 abrogated the IFN-gamma response to adiponectin, whereas extracellular signal-regulated kinase 1/2 inhibition by PD98059 did not affect the response."

18666256

---

➶

tas

No evidence text available

12361396

---

➶

medscan

"Inhibition of p38 mitogen-activated protein kinase by SB203580 counteracted the influence of IL-1beta on Fhl2 and Tubb expression, indicating partial involvement of this signaling pathway."

18224250

---

➶

trips

"This p38 MAP kinase, like p38 alpha, is inhibited by the pyridinyl imidazole drug SB203580."

9430721

---

➶

tas

No evidence text available

11140741

---

➶

tas

No evidence text available

18325768

---

➶

medscan

"Activation of the ERK or p38 mitogen-activated protein kinase pathways with PMA or anisomycin decreased dimerization, an effect that was largely prevented when PMA treatment was combined with U0126, which inhibits the ERK mitogen-activated protein kinase pathway, or anisomycin treatment was combined with SB203580, which inhibits p38 mitogen-activated protein kinase."

22550340

---

➶

medscan

"The inhibition of the p38-kinase by SB203580 or infection with a dominant negative p38 kinase adenovirus significantly increased basal number of endothelial progenitor cells (136.7+/-6.3% and 142.9+/-18% versus control, respectively)."

15753227

---

➶

signor

"Pretreatment of hela cells with sb 203580, a pyridinyl imidazole compound that specifically inhibits p38 mitogen-activated protein kinase (mapk). It has previously been established that sb 203580 acts primarily to block the catalytic activity of p38 mapk. However, it has been suggested that in cells, the compounds could also inhibit p38 mapk activation by virtue of their ability to bind to the inactive enzyme."

15208625

---

➶

reach

"SB203580 is a competitive inhibitor of p38alpha and p38beta by blocking ATP binding to the kinase, while BIRB796 is an allosteric inhibitor of p38alpha, p38beta, and p38gamma."

23315073

---

➶

tas

No evidence text available

23602399

---

➶

reach

"Conversely, the inhibition of MAPK14 by SB203580 and the down-regulation of MAP2K3 and MAP2K6 (kinases upstream of MAPK14) by specific siRNA did not alter the activation of MAPK3/1."

21084714

---

➶

tas

No evidence text available

15454232

---

➶

signor

"Pretreatment of hela cells with sb 203580, a pyridinyl imidazole compound that specifically inhibits p38 mitogen-activated protein kinase (mapk). It has previously been established that sb 203580 acts primarily to block the catalytic activity of p38 mapk. However, it has been suggested that in cells, the compounds could also inhibit p38 mapk activation by virtue of their ability to bind to the inactive enzyme."

10702313

---

➶

medscan

"SB203580 [4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl) 1 H-imidazole; Calbiochem] directly inhibits the activation of p38 mitogen-activated protein kinase, and SP600125 (1,9-Pyrazoloanthrone; Calbiochem) preferentially inhibits anti-c-Jun N-terminal kinase 1/2."

26323834

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➶

reach

"PD 98059 prevents the activation of MAP kinase kinase-1 [12], the enzyme that activates the MAP kinase family members MAPK1 and ERK1 and MAPK2 and ERK2 in the ` classical ' MAP kinase cascade, while SB 203580 inhibits the MAP kinase family members SAPK2a and p38 and SAPK2b and p38beta2 [13] which are components of a distinct protein kinase cascade (reviewed in [14])."

9662426

---

➶

tas

No evidence text available

| DOI

---

➶

medscan

"In addition, (-)-epigallocatechin gallate induced phosphorylation of p38 mitogen-activated protein kinase , a stress-inducible kinase believed to negatively regulate tumorigenesis, and the inhibition of p38 mitogen-activated protein kinase by SB203580, a specific p38 mitogen-activated protein kinase inhibitor, or the gene silencing using p38 mitogen-activated protein kinase-small interfering RNA suppressed the internalization and subsequent degradation of EGFR induced by (-)-epigallocatechin gallate."

19578043

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➶

tas

No evidence text available

12086485

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➶

medscan

"Of note, the inhibition of ERK or p38 mitogen-activated protein kinase by U0126 or SB203580, respectively, decreased the apoptosis induced by cisplatin; however, enhanced apoptotic effects were observed with the use of ERK/p38 mitogen-activated protein kinase inhibitor in combination with butein."

26310353

---

➶

medscan

"Following pretreatment with mitogen-activated/extracellular signal-regulated kinase kinase (MEK) inhibitor U0126, extracellular signal-regulated kinase (ERK) inhibitor PD098059, and P38 mitogen-activated protein kinase (P38MAPK) inhibitor SB203580 for 30 min, chondrocytes were treated with OPG, and Cell Counting kit-8 was performed."

24126801

---

➶

tas

No evidence text available

10999467

---

➶

tas

No evidence text available

18006306

---

➶

tas

No evidence text available

12852754

---

➶

tas

No evidence text available

16169718

---

➶

tas

No evidence text available

21696951

---

➶

medscan

"Progesterone could repress the activation of iNOS through P38mitogen activated protein kinase pathway within polymorphonuclear leukocytes (P<0.05), which could be blocked by SB203580 (P<0.01), but not by actinomycin D (P>0.05)."

20155468

---

➶

medscan

"We investigated the role of p38 MAP kinase in activating NADPH oxidase stimulated by the bacteria-derived peptide fMLP. fMLP-stimulated superoxide production was completely abolished by SB203580, a p38 MAP kinase inhibitor, whereas anisomycin, a p38 MAP kinase activator, did not induce superoxide production, indicating that p38 MAP kinase was essential, but not sufficient, for NADPH oxidase activation. 1999999={EffectorType="agonist" Target=1432}}"

17030506

---

➶

tas

No evidence text available

12061876

---

➶

tas

No evidence text available

24508134

---

➶

tas

No evidence text available

22676210

---

➶

tas

No evidence text available

24131218

---

➶

tas

No evidence text available

15341957

---

➶

tas

No evidence text available

18373337

---

➶

medscan

"Cells were transfected with 100 nM p38 mitogen-activated protein kinase small interfering RNA or 2 μg mitogen-activated protein kinase kinase 3 expression vector (a specific kinase that directly activates p38 mitogen-activated protein kinase) in the presence or absence of fluticasone (100 nM) and/or p38 mitogen-activated protein kinase pharmacological inhibitor SB203580."

24024586

---

➶

reach

"Phosphorylation was not prevented by SB 203580 (an inhibitor of SAPK2a and p38alpha and SAPK2b and p38beta2) and/or PD 184352 (which inhibits the activation of ERK1 and ERK2), and was similar in fibroblasts lacking both SAPK3 and p38gamma and SAPK4 and p38delta or JNK1 and JNK2."

15362974

---

➶

medscan

"SB203580 (10µM) treatment, which almost completely reduces Hsp27 phosphorylation by p38α/β although p38γ and p38δ are also expressed ( ), inhibited p53 mRNA (48hrs), protein expression and activity ( and ) in D-HEp3 cells."

19584293

---

➶

medscan

"SB203580 concentration-dependently inhibited p38MAPK pathway and induced uPA protein expression."

17222367

---

➶

medscan

"SB203580 inhibits p38α but not p38δ activity ( )."

20685965

---

➶

tas

No evidence text available

18578517

---

➶

medscan

"P38MAPK-blocking pharmacon SB203580 also significantly inhibited the up-regulation of BIM in CEM-C7 cells."

20697841

---

➶

tas

No evidence text available

10999468

---

➶

tas

No evidence text available

20000735

---

➶

medscan

"SB203580 down-regulated the activity of p38MAPK pathway, but up-regulated EGR-1 expression."

18704310

---

➶

sparser

"Inhibition of p38alpha by the specific inhibitor SB 203580 prevented activation-induced cell death in T cells."

10464315

---

➶

medscan

"MMP-9 secretion was decreased 53.2% by inhibition of the p38 mitogen-activated protein kinase by SB203580 (P < 0.01) and 48.3% by inhibition of extracellular signal-regulated kinase with PD98059 (P < 0.05)."

17575075

---

➶

tas

No evidence text available

19253982

---

➶

tas

No evidence text available

15990304

---

➶

tas

No evidence text available

20188577

---

➶

tas

No evidence text available

23270382

---

➶

tas

No evidence text available

15943486

---

➶

medscan

"Bay 11-7082-induced neutrophil survival was dependent on p38-MAPK kinase activity, as the p38 kinase activity inhibitor SB203580 abrogated this response completely."

20573801

---

➶

tas

No evidence text available

17181176

---

➶

medscan

"Inhibition of p38 mitogen-activated protein kinase using SB203580 and small interfering RNA transfection resulted in a significant reduction in BFT-induced I kappaB kinase /NF-kappaB activation and hBD-2 expression."

20231411

---

➶

medscan

"Inhibition of p38 mitogen-activated protein kinase by SB 203580 had no influence on ajoene-mediated apoptosis."

12555071

---

➶

tas

No evidence text available

15711537

---

➶

medscan

"Moreover, these responses are maintained in the presence of SB203580, an agent that inhibits p38 alpha and beta, further suggesting a central role for the p38 delta isoform."

12810719

---

➶

reach

"SB203580 has been used to inhibit MAPK14 and p38-alpha and MAPK11 and p38-beta with IC 50 = 50 nM and 500 nM respectively XREF_BIBR, XREF_BIBR."

24901709

---

➶

reach

"The compound SB203580 specifically inhibits p38 and CSBP kinase activities, whereas PD098059 selectively blocks activation of the ERK kinase MEK1, which in turn prevents activation of ERK1/2."

9529323

---

➶

medscan

"We discovered that both PAR1 and P2Y1 promote p38 activation through autophosphorylation, since the process was inhibited by SB203580, which blocks p38-α and p38-β activity but does not perturb phosphorylation of p38 mediated by upstream MAPKs ( ; )."

26391660

---

➶

sparser

"Moreover, the pyridinyl-imidazole compounds SB 203580 and SB 202190 inhibit SAPK2a and SAPK2b, but not SAPK3 and SAPK4 ."

9199504

---

➶

tas

No evidence text available

---

➶

medscan

"Next, we blocked p38 signaling with SB203580, a pyridinyl imidazole that inhibits the kinase activity of p38α and p38β without affecting p38 phosphorylation."

25263448

---

➶

reach

"XREF_BIBR In addition, inhibition of MAPK14 by SB203580 has previously been associated with autophagic cell death as characterized by the accumulation of large cytosolic vacuoles."

24300666

---

➶

tas

No evidence text available

16750367

---

➶

sparser

"SB 203580 inhibits p38α, β and β2 (not γ and δ) MAP kinase by competing with the substrate ATP [ xref , xref ]."

27505423

---

➶

tas

No evidence text available

8831759

---

➶

medscan

"The specific inhibitor of p38 MAPK (SB203580), and silencing of p38α MAPK by small interfering RNAs , but not ERK1/2 inhibitor (PD98059) blocked the stimulatory effects of Berberine on protein expression of p53 and FOXO3a."

24766860

---

➶

tas

No evidence text available

28280261

---

➶

medscan

"Interestingly, inhibition of p38 mitogen-activated protein kinase by SB203580 severely decreased induction of COX-2 expression by IL-1beta. p38 mitogen-activated protein kinase signalling was required for Interleukin-1beta-dependent stabilization of COX-2 transcript."

16326073

---

➶

reach

"The observation that overexpression of wild-type S6K in HEK293 cells increases the IC 50 10-fold from that of endogenous S6K in fibroblasts raises the possibility that Ro 31-6045 also targets the inactive form of the kinase, as reported for the inhibition of MKK1 by U0126 and PD 184352 [14] and SAPK2a by SB 203580 [27]."

12023032

---

➶

tas

No evidence text available

22897496

---

➶

tas

No evidence text available

11855979

---

➶

tas

No evidence text available

20471255

---

➶

reach

"Moreover, the pyridinyl-imidazole compounds SB 203580 and SB 202190 [41] inhibit SAPK2a and SAPK2b, but not SAPK3 and SAPK4 [24]."

9199504

---

➶

tas

No evidence text available

19751974

---

➶

reach

"SB203580 has been well characterized to inhibit the SAPK2a and 2b isoforms of p38 by> = 90% without appreciably (< 30%) affecting related kinases such as ERK (extracellular signal regulated kinase) or JNK (c-Jun N-terminal kinase), or 17 other widely expressed kinases."

20357001

---

➶

medscan

"The levels of HO-1 and p21 induced were significantly inhibited by p38 mitogen-activated protein kinase (p38 MAPK) inhibitor (SB203580) and extracellular-regulated kinase (ERK) inhibitor (PD098059)."

14647439

---

➶

medscan

"Inhibition of p38 mitogen-activated protein kinase by SB203580 prevented increases in paracellular permeability, actin rearrangement, and increases in the F-/G-actin ratio caused by IFN-γ."

25830506

---

➶

medscan

"Forced inhibition of p38 mitogen-activated protein kinase activity by the specific pharmacological inhibitor SB203580 or by p38 mitogen-activated protein kinase gene knockdown using small-interfering RNA counteracted the effects of FL3, demonstrating that its chemopreventive action is related to growth inhibition and a p38-dependent caspase-3-dependent induction of apoptosis in Oct4-expressing Cancer stem cells."

24607276

---

➶

tas

No evidence text available

22037378

---

➶

medscan

"Unlike SAPK2a and SAPK2b, SAPK4 and SAPK3 were not inhibited by the drugs SB 203580 and SB 202190."

9218798

---

➶

medscan

"Knockdown of HSP27 and PKDs markedly inhibited VEGF-induced Human Umbilical Vein Endothelial Cells migration and tubulogenesis, whereas inhibition of the p38 kinase pathway using either SB203580 or siRNAs against p38alpha or MAPKAPK2, had no significant effect on the chemotactic response to VEGF."

18440775

---

➶

tas

No evidence text available

11354358

---

➶

signor

"Pretreatment of hela cells with sb 203580, a pyridinyl imidazole compound that specifically inhibits p38 mitogen-activated protein kinase (mapk). It has previously been established that sb 203580 acts primarily to block the catalytic activity of p38 mapk. However, it has been suggested that in cells, the compounds could also inhibit p38 mapk activation by virtue of their ability to bind to the inactive enzyme."

11606413

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

18183025

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➶

tas

No evidence text available

10377223

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➶

reach

"It is not blocked by SB 203580, which inhibits SAPK2a and p38alpha and SAPK2b and p38beta but not SAPK3 and p38gamma, or by the ERK pathway inhibitor PD 184352."

14741046

---

➶

medscan

"Furthermore, suppression of extracellular signal-regulated kinases and p38 mitogen-activated protein kinase activity by their specific inhibitors, U0126 and SB203580, abrogated CD24-induced proliferation in vitro."

19860845

---

➶

tas

No evidence text available

17411025

---

➶

tas

No evidence text available

15454231

---

➶

medscan

"Inhibition of p38 mitogen-activated protein kinase by SB203580 attenuated Oxidized low density lipoprotein-induced calcification of vascular smooth muscle cells."

24358176

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➶

tas

No evidence text available

24900264

---

➶

medscan

"By contrast, direct inhibition of p38 mitogen-activated protein kinase (inhibitor SB203580) efficiently suppresses IL-8 with potency comparable with dexamethasone."

21454676

---

➶

medscan

"Interestingly, a specific phosphoinositide 3-kinase /Akt inhibitor (LY294002) augmented the As4O6 induced cell death; whereas p38 mitogen-activated protein kinases (p38 MAPK) inhibitor (SB203580) abrogated the cell death."

28355296

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➶

sparser

"P38α and p38β are inhibited by SB 203580 and SB 202190, with IC 50 s of 0.092 μM and 1 μM, respectively."

10454214

---

➶

medscan

"Interestingly, activation of CD30 induced a strong synergistic reduction of cell activity, if the p38 mitogen-activated protein kinase activity was blocked by SB203580."

15291361

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➶

tas

No evidence text available

20663667

---

➶

medscan

"Additionally, we showed that following DNA damage, activation of p38 kinase was significantly elevated, while Erk kinase activation was decreased in mutant cells, and treatment of SHP-2 mutant cells with SB203580, a selective inhibitor for p38 kinase, partially restored the DNA damage-induced G2 arrest response."

12937170

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➶

reach

"Glycogen synthase becomes phosphorylated at Ser644 in response to osmotic shock; this phosphorylation is prevented by pretreatment of the cells with SB 203580, which inhibits SAPK2a and p38a and SAPK2b and p38b activity."

14680475

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➶

medscan

"ERK1/2 phosphorylation was blocked by U0126 but not by SB203580, and p38(MAPK) activity was reduced by SB203580 but not by U0126."

26881015

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➶

tas

No evidence text available

15012994

---

➶

medscan

"The involvement of p38 mitogen activated-protein kinase in the up-regulation of IL-6 and IL-8 by HIV-1 Tat was determined by pretreating the astrocytes with SB203580, a specific inhibitor of p38 mitogen activated-protein kinase. p38 mitogen activated-protein kinase exists in four different isoforms (α/β/γ/δ), of which SB203580 inhibits the p38α and p38β isoforms [ ]."

25539898

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➶

signor

"Pretreatment of hela cells with sb 203580, a pyridinyl imidazole compound that specifically inhibits p38 mitogen-activated protein kinase (mapk). It has previously been established that sb 203580 acts primarily to block the catalytic activity of p38 mapk. However, it has been suggested that in cells, the compounds could also inhibit p38 mapk activation by virtue of their ability to bind to the inactive enzyme."

10512765

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➶

tas

No evidence text available

17923491

---

➶

reach

"SB203580, a pyridinyl imidazole which inhibits SAPK2a [34], has been widely used to implicate this signalling pathway in the phosphorylation of eIF4E [2,3,5,16,18-21,28]."

12781867

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➶

medscan

"To determine if thrombin activates p38 through the canonical three-tiered kinase cascade, we used the p38 inhibitor SB203580, which specifically inhibits the catalytic activity of p38-α and -β isoforms without blocking p38 phosphorylation mediated by the upstream kinases ( )."

26391660

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➶

tas

No evidence text available

12039561

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➶

sparser

"Unlike SAPK1 (also called JNK), SAPK3 and SAPK4 did not phosphorylate the activation domain of c-Jun. Unlike SAPK2a and SAPK2b, SAPK4 and SAPK3 were not inhibited by the drugs SB 203580 and SB 202190."

9218798

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➶

trips

"Although CA treatment decreased the phosphorylation of p38 mitogen‑activated protein (MAP) kinase and p53, p38 MAP kinase inhibition by SB203580 did not affect SM‑induced cell death."

27665716

---

➶

tas

No evidence text available

19591487

---

➶

medscan

"The chemical inhibitor SB203580 inhibits the p38α and p38β isoforms, but not the p38γ or p38δ isoforms ."

24658403

---

➶

tas

No evidence text available

15566301

---

➶

tas

No evidence text available

17323937

---

➶

medscan

"In contrast, cell migration and p38 MAP kinase activation, in response to Sphingosine 1-phosphate, were inhibited by SB203580 but not by PD98059."

10794715

---

➶

medscan

"Inhibition of p38 mitogen-activated protein kinase (by SB202190 and SB203580) or a dominant-negative mutant of Sema-3A receptor plexin-A1 reversed the inhibitory effects of VEGF in normal mesothelial cells, increasing cyclin D1 synthesis and cell growth."

14656993

---

➶

tas

No evidence text available

20481631

---

➶

tas

No evidence text available

9873604

---

➶

medscan

"SB203580 was used to inhibit the p38 mitogen-activated protein kinase signaling pathway."

28167124

5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylidene-4-imidazolidinone affects RIPK1

1 2 | 24 65

5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylidene-4-imidazolidinone inhibits RIPK1. 92 / 92

1 2 | 24 65

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➶

reach

"The necrostatin-1 inhibits RIP1 kinase activity, which is required to trigger necroptosis pathway."

28947974

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➶

reach

"Moreover, necrostatin-1, an inhibitor that targets RIP-1, has been shown to exert neuroprotective functions and to shield neurons from cell death following CCI-TBI."

22437344

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➶

reach

"Furthermore, heme mediated cell death is unaffected by the addition of necrostatin-1 (a specific inhibitor of RIP1) (results not shown)."

26270345

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➶

reach

"Necrostatin-1 (an inhibitor of RIPK1, RIPK3-KO, and MLKL-KO) mice were recently used to demonstrate the role of necroptosis in IR- and cisplatin induced AKI."

26924060

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➶

reach

"The RIP1 antagonist necrostatin-1 prevented the loss of ES-MNs exposed to either mutSOD1 or sALS (XREF_FIG) astrocytes."

24508385

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➶

sparser

"Necrostatin-1 inhibits RIPK1 by blocking its association with RIP3."

29212215

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➶

reach

"Necrostatin-1 blocks both RIPK1 and IDO : consequences for the study of cell death in experimental disease models."

23197293

---

➶

reach

"Inhibition of RIP1 by Necrostatin-1 partially rescued cells from imatinib deprivation induced cell death, indicating that this necrotic and necroptotic signaling pathway substitutes for the blocked apoptosis at least partially."

21949869

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➶

sparser

"In contrast, RIP1 expression in mouse liver remained unchanged following ethanol feeding and inhibition of RIP1 kinase by necrostatin-1 did not attenuate ethanol-induced hepatocyte injury."

23319235

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➶

reach

"We also included necrostatin-1, which inhibits RIP1 kinase activity and therefore necroptosis."

27302486

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➶

reach

"The LPS or bacterial induced necroptosis in wild type BMDMs was also inhibited by Necrostatin-1 (Nec-1), indicating a RIPK1 kinase dependency (XREF_SUPPLEMENTARY)."

27264187

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➶

reach

"Inhibition of RIP1 by necrostatin-1 did not inhibit A1-IRS activity, thereby excluding necroptosis (XREF_SUPPLEMENTARY)."

25356869

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➶

reach

"Necrostatin-1 inhibits the kinase activity of RIP1 26 while necrosulfonamide targets MLKL, which has recently emerged as a key signaling protein that mediates binding to downstream targets."

23985697

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➶

reach

"Inhibition of RIP1 by necrostatin-1 clearly protected from TNF induced necroptosis in all three L929 sublines, but had no effect on the course of MNNG induced necrosis over 16h."

23760205

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➶

sparser

"Necrostatin-1 specifically inhibits RIP1 kinase and disrupts regulated necrosis in tissue culture xref – xref ."

23145018

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➶

reach

"ZVAD-FMK (an inhibitor of pan-caspase), necrostatin-1 (a selective inhibitor of RIPK1), and chloroquine (an inhibitor of autophagy by raising the lysosomal pH) can not block ferroptosis [XREF_BIBR]."

29038744

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➶

reach

"Additionally, while the effect of Y100 was abrogated by necrostatin-1 (an inhibitor of the necroptosis effector RIPK1), neither siRNA mediated knockdown of RIPK1 nor inhibition of RIPK3 with GSK ' 872 was sufficient to prevent Y100 mediated cell death (XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY)."

29662612

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➶

reach

"Recently, receptor interacting protein-1 (RIP1)-dependent necrosis, which is inhibited by necrostatin-1, an inhibitor of RIP1, has emerged as a form of regulated necrosis."

21888904

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➶

reach

"XREF_BIBR and XREF_BIBR Although inhibition of necroptosis by RIP3 deficiency, RIP1 blockade by necrostatin-1, or MLKL deficiency all reduce cell death at early time points, XREF_BIBR and XREF_BIBR RIP3 deficiency was unable to abrogate acetaminophen induced liver injury at 24 hours."

25046161

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➶

reach

"In addition, necroptosis can be manipulated by inhibitors such as Necrostatin 1, which blocks RIP1 kinase activity."

26500646

---

➶

reach

"Furthermore, we tested an inactive analog of necrostatin-1, necrostatin-1I, which does not inhibit RIPK1 or necroptosis in other settings."

23386613

---

➶

reach

"Necrostatin-1 administration inhibited the upregulation of RIP1 and RIP3 and enhanced the expression of caspase-8 in DSS induced colitis."

26693068

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➶

sparser

"Inhibition of RIP1 by necrostatin-1 did not inhibit A1-IRS activity, thereby excluding necroptosis ( xref ). xref We also looked for mitochondrial perturbation and did not observe any cytochrome C redistribution ( xref ) or ROS increase ( xref ) after incubation with A1-IRS, and mitochondria appeared normal when observed under electronic microscopy (data not shown)."

25356869

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➶

reach

"9 Generation of the kinase receptor interacting protein 1 (RIP1)/RIP3 containing ' necrosomes ' activates downstream necroptotic signaling, which can be inhibited by necrostatin 1 (XREF_FIG)."

24336086

---

➶

reach

"Inhibition of RIP-1 by Necrostatin-1 also did not alter cell death in male or female cells (not shown)."

23928697

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➶

sparser

"Indeed, inhibition of RIP1 by necrostatin-1 abolishes both apoptosis and necrosis in RPE cells."

28615451

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➶

sparser

"Here, we investigated whether inhibiting RIPK1 by necrostatin-1 (Nec-1) could limit neuroinflammation and attenuate POCD in D-Galactose (D-Gal)-induced aged mice."

30042663

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➶

sparser

"Necrostatin-1 (Nec-1) inhibits receptor-interacting protein 1 (RIP1) kinase and programmed necrosis."

24198446

---

➶

sparser

"We found that RIP-1 expression was upregulated in the lung of ALI mice and inhibition of RIP-1 by necrostatin-1 significantly prolonged the survival time of mice, which was accompanied by less serve lung injury."

29199874

---

➶

sparser

"Generally, necroptosis is defined as cell death mediated through a pathway that depends on the RIPK1-RIPK3 complex that may be inhibited by necrostatin-1 (Nec-1) ( xref )."

27177159

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➶

reach

"In an OS model, RIPK1 mediated necroptosis was confirmed as the main cell death mechanism involved in Shikonin therapy, as only Necrostatin-1 (an inhibitor of RIPK1) was able to induce treatment reversion."

25905041

---

➶

reach

"6 Necrostatin-1 (Nec-1) prevents necroptosis by binding to and inactivating RIP1."

28250973

---

➶

sparser

"Inhibition of RIP-1 by Necrostatin-1 also did not alter cell death in male or female cells (not shown)."

23928697

---

➶

reach

"Since necrostatin-1 has been shown to block not only RIPK1 but also indoleamine 2,3-dioxygenase (IDO), the IDO2 specific inhibitor 1-methyl-D-tryptophan (1-MT) was added to BMDC cultures as a control."

24808358

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➶

reach

"In line with its essential role in programmed necrosis, pharmacological inhibition of RIPK1 by necrostatin-1 protected the same subset of sensitive tumor cell lines that we had used for analysis in Figure XREF_FIG d (resistant KNS-62 cells were again included as control) from both TRAIL/zVAD/CHX- and TNF/zVAD/CHX induced programmed necrosis."

24507727

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➶

sparser

"Inhibition of RIPK1 by Necrostatin-1s (Nec1s) resulted in reduced, but not totally inhibited, caspase activation and cell death, demonstrating simultaneous occurrence of RIPK1 kinase-dependent and -independent apoptosis (Fig. xref )."

31534131

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➶

reach

"64 Indeed, genetic deletion of RIPK3 in Casp8 -/- dendritic cells rescues LPS induced IL-1beta production from Casp8 -/- dendritic cells, and necrostatin-1 (a chemical inhibitor of RIPK1 kinase activity) treatment inhibits LPS induced IL-1beta production from Casp8 -/- dendritic cells."

25451151

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➶

sparser

"Necroptosis was significantly reduced when RIP1 kinase was inhibited by necrostatin-1, whereas inhibition of caspases with z-vad-fmk, an irreversible pan-caspase inhibitor, did not prevent necroptosis."

22372834

---

➶

reach

"Necroptosis induction requires the activity of RIP-1 kinase, which can be repressed by necrostatin-1 (Nec-1)."

25725104

---

➶

reach

"Indeed, inhibition of RIP1 by necrostatin-1 abolishes both apoptosis and necrosis in RPE cells."

28615451

---

➶

sparser

"Inhibition of RIP1 by necrostatin-1 clearly protected from TNF-induced necroptosis in all three L929 sublines, but had no effect on the course of MNNG-induced necrosis over 16 h (Fig.  xref b)."

23760205

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➶

tas

No evidence text available

27992216

---

➶

reach

"Though Necrostatin-1 has been widely used to inhibit RIPK1 kinase activity, off-target effects have been reported."

28366204

---

➶

reach

"The pharmacologic small molecule necrostatin 1 inhibits RIPK1 and prevents necroptosis in most cellular models -- a very useful experimental tool."

23720337

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➶

reach

"26 Here, we show that LTX-315 also can induce ICD in the context of a necrotic pathway that is independent of RIP3 (and is not inhibited by necrostatin 1, which inhibits RIP1), XREF_BIBR, XREF_BIBR suggesting that different pathways leading to necrosis can cause ICD."

26962684

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➶

tas

No evidence text available

---

➶

sparser

"Moreover, RIP1 inhibition by necrostatin-1 only reduces mitochondrial but not cytosolic ROS elevation (Fig.  xref )."

26381601

---

➶

reach

"Necrostatin-1 (Nec-1) specifically blocks the kinase activity of RIPK1 [XREF_BIBR]."

23301705

---

➶

reach

"Necrostatin-1 specifically inhibits RIP1 kinase and disrupts regulated necrosis in tissue culture XREF_BIBR - XREF_BIBR."

23145018

---

➶

reach

"This is consistent with the notion that Necrostatin-1 inhibits RIPK1 kinase activity, which is required for the formation of RIPK1/FADD/caspase -8 complex (Degterev et al., 2008; Wang et al., 2008)."

19524512

---

➶

reach

"This TNF-alpha and Fas-induced cell death is a type of receptor interacting protein-1 (RIP-1)-dependent programmed necrosis called necroptosis, which can be prevented by necrostatin-1, a specific RIP-1 inhibitor."

21989986

---

➶

sparser

"Inhibition of RIP1 by Necrostatin-1 partially rescued cells from imatinib deprivation-induced cell death, indicating that this necrotic/necroptotic signaling pathway substitutes for the blocked apoptosis at least partially."

21949869

---

➶

reach

"20 Necrostatin-1 and an optimized derivative of necrostatin-1 (7-Cl-O-Nec-1) are small molecules inhibitors of RIP1."

25563840

---

➶

sparser

"Inhibition of RIP1 by Necrostatin-1 and even more effectively p38-MAPK inhibition by the p38 inhibitor III rescued cells from imatinib deprivation induced cell death ( xref , right panel), indicating that these proteins play a major role for cell death upon oncogenic stress."

21949869

---

➶

reach

"Z-VAD-FMK (a caspase inhibitor) and necrostatin-1 (a specific inhibitor of RIPK1) were utilized to determine whether the cell death was mediated by RIPK1 or caspases."

29760660

---

➶

reach

"In the second approach, we turned to a fragment based strategy, combining a hinge binding fragment of ponatinib with a highly selective necrostatin-1 inhibitor of RIPK1."

26472031

---

➶

reach

"Necrostatin-1 blocks necroptosis in many settings by interacting and inhibiting RIPK1 kinase activity, which is required for activation of RIPK3."

26491219

---

➶

sparser

"Inhibition of RIP-1 by Necrostatin-1 (Nec-1) in SW620 cells ameliorated cell death and AIF translocation after AA005 treatment (Figure  xref B, C), whereas AIF knockdown failed to affect the increase in RIP-1 evoked by AA005 (Figure  xref D)."

25885900

---

➶

reach

"And, necrostatin-1 could effectively reverse the changes of pulmonary fibrosis, RIPK1, RIPK3, and ECM in vivo and in vitro experiments."

32019905

---

➶

reach

"To determine if necroptosis was involved in the neurotoxicity induced by miR-21, we treated the cultures with necrostatin-1, which specifically inhibits RIPK-1."

26154133

---

➶

reach

"In vitro, human neutrophils fed CA-MRSA lyse by an unknown mechanism that is inhibited by necrostatin-1, an allosteric inhibitor of receptor interacting serine/threonine kinase 1 (RIPK-1)."

28473408

---

➶

sparser

"Inhibiting RIPK1 and RIPK3 by their inhibitors Necrostatin-1 (Nec-1) and GSK-872, respectively, showed effective activities against osteoclast differentiation and bone resorption induced by receptor activator of nuclear factor-κB ligand (Rankl)."

32321638

---

➶

reach

"Inhibition of RIP-1 by Necrostatin-1 (Nec-1) in SW620 cells ameliorated cell death and AIF translocation after AA005 treatment, whereas AIF knockdown failed to affect the increase in RIP-1 evoked by AA005."

25885900

---

➶

sparser

"Thus, we here induced aged mice via intraperitoneal injection of D-Gal for 2 months and detected the effects of inhibiting RIPK1 by necrostatin-1 (Nec-1; Yang et al., xref ) on POCD in the aged mice."

30042663

---

➶

reach

"In particular, necrostatin-1 has been identified to specifically inhibit the kinase activity of RIP1, thereby undermining its interaction with RIP3 and antagonizing necroptosis, without affecting NF-kappaB XREF_BIBR."

24714696

---

➶

reach

"In a previous study, we showed that expression of the tnt gene in Jurkat T cells (Jurkat 655-TNT) induced a necrotic like cell death that was not prevented by necrostatin-1, indicating RIPK1 independent necrosis."

29996103

---

➶

reach

"S. aureus can also trigger necroptosis, cell death dependent on RIPK1, RIPK3, and MLKL that can be blocked by necrostatin-1 and necrosulfonamide (NSA)."

27460814

---

➶

reach

"We found that RIP-1 expression was upregulated in the lung of ALI mice and inhibition of RIP-1 by necrostatin-1 significantly prolonged the survival time of mice, which was accompanied by less serve lung injury."

29199874

---

➶

reach

"Furthermore, necrostatin-1 significantly downregulated necroptosis related proteins (MLKL, RIP1, and RIP3) and apoptosis related proteins (cleaved-Caspase-3, Bax), and it upregulated the expression of anti-apoptotic protein Bcl-2."

31719260

---

➶

reach

"A necrostatin-1 dose response for the concentration of necrostatin-1 required to inhibit the RIP1 activity in U1 cells was determined by EGFRvIII driven phosphorylation of phospho-p65 (XREF_SUPPLEMENTARY)."

23972990

---

➶

reach

"Necroptosis was significantly reduced when RIP1 kinase was inhibited by necrostatin-1, whereas inhibition of caspases with z-vad-fmk, an irreversible pan-caspase inhibitor, did not prevent necroptosis."

22372834

---

➶

reach

"However, it is certain that Ser161 contributes to necrostatin-1 (Nec-1)-mediated inhibition of RIP1 kinase activity."

27383048

---

➶

reach

"DAPE induced reduction of NCI-H28 cell viability was partially inhibited by necrostatin-1, an inhibitor of RIP1 kinase to induce necroptosis, or knocking-down RIP1."

26004138

---

➶

reach

"Conversely, necroptosis is dependent on RIP1 kinase activity, which can by inhibited by necrostatin-1 (nec-1)."

23555634

---

➶

reach

"Necrostatin-1 (Nec-1) inhibits receptor interacting protein 1 (RIP1) kinase and programmed necrosis."

24198446

---

➶

sparser

"In line with its essential role in programmed necrosis, pharmacological inhibition of RIPK1 by necrostatin-1 protected the same subset of sensitive tumor cell lines that we had used for analysis in Figure  xref d (resistant KNS-62 cells were again included as control) from both TRAIL/zVAD/CHX- and TNF/zVAD/CHX-induced programmed necrosis (Figure  xref a)."

24507727

---

➶

reach

"By using a chemical approach, we showed that pretreatment of mice with Necrostatin-1 (Nec-1) (inhibitor of RIPK1) and/or PJ34 (inhibitor of PARP-1) significantly protected mice against concanavalin A (ConA) liver injury (aspartate amino-transferase (AST)/alanine amino-transferase (ALT)) associated with down-regulated hepatocyte specific IL-33 expression."

25747661

---

➶

reach

"Necrostatin-1 specifically inhibits the pro necrotic RIP1 kinase activity, but not the kinase activities of other kinases including RIP2 and RIP3 [XREF_BIBR, XREF_BIBR]."

20532807

---

➶

reach

"Necrostatin-1 treatment abrogated association of RIPK1 and MLKL with ATG5 (XREF_FIG), indicating a requirement for RIPK1 kinase activity for complex formation."

27219062

---

➶

sparser

"However, inhibiting Ripk1 directly by necrostatin-1 did not rescue cell death induced by N-Gsdma3, indicating that mitochondrial targeting is crucial for Gsdma3 activation."

26100518

---

➶

reach

"In addition, it was identified that the increased RIPK1 and RIPK3 can be inhibited by necrostatin-1 in both in vivo and in vitro."

32345086

---

➶

reach

"Inhibition of RIP1 by Necrostatin-1 and even more effectively p38-MAPK inhibition by the p38 inhibitor III rescued cells from imatinib deprivation induced cell death (XREF_FIG, right panel), indicating that these proteins play a major role for cell death upon oncogenic stress."

21949869

---

➶

reach

"Moreover, RIP1 inhibition by necrostatin-1 only reduces mitochondrial but not cytosolic ROS elevation."

26381601

---

➶

sparser

"In addition, it was identified that the increased RIPK1 and RIPK3 can be inhibited by necrostatin-1 in both in vivo and in vitro ."

32345086

---

➶

sparser

"Inhibiting RIPK1 by necrostatin-1 strikingly mitigated cognitive impairment and alleviated postoperative amplified neuroinflammation, necroptosis and GluA1 loss in hippocampus."

30042663

---

➶

sparser

"However, it should be noted that, although inhibition of RIP1 kinase by necrostatin-1 did not have an effect on the cytotoxic activity of NaD1, the ability of NaD1 to effect the necroptotic pathway downstream of RIP1 kinase activity, such as via direct modulation of MLKL-mediated membrane disruption, xref not addressed in our current study should be determined to eliminate definitively necroptosis as having a role."

28179997

---

➶

reach

"Necroptosis is another pathway leading to programmed cell death; necroptosis is inhibited by necrostatin-1 which blocks RIP1 kinase, an essential component of the pathway [XREF_BIBR, XREF_BIBR]."

28622381

---

➶

reach

"Mechanistically, we show that inactivation of RIP1 by necrostatin-1 suppressed nuclear factor kappaB (NF-kappaB) cascade signals, including activation of IKKalpha, nuclear factor kappa B inhibitor protein alpha (IkappaBalpha), accumulation of nuclear p65 and NF-kappaB promoter activity."

30372886

---

➶

reach

"Further, Necrostatin-1 (Nec-1) -- an inhibitor of RIP1 kinase activity -- dramatically increased baculoviral transgene expression in RIP1 silenced cells."

28831401

---

➶

signor

"The interaction between rip1 and rip3 is abolished by the rip1 kinase inhibitor necrostatin-1."

19524513

---

➶

reach

"In rodents, it has previously been shown that necrostatin-1 (Nec-1) inhibits RIP1, a central regulator of programmed necrosis, thereby decreasing cell death and reducing infarct size (IS) after ischaemia and reperfusion (I/R) injury."

25496079

---

➶

reach

"Necrostatin-1 blocks the association of RIP1 with RIP3, leading to RIP3 instability, and cleavage from a 57-kDa to a 55-kDa protein."

29212215

Lipopolysaccharide affects RELA

2 | 89

Lipopolysaccharide inhibits RELA. 91 / 91

2 | 89

---

➶

reach

"In addition, MSL significantly inhibited nuclear translocation of NF-kappaB p65 in cells treated with LPS in vitro."

27620503

---

➶

reach

"Our results showed that LPS treatment caused the decrease of p65 and p50 in the cytoplasm and increase in nucleus, and this effect can be reversed by the pretreatment with WEL in a dose dependent manner."

24176090

---

➶

reach

"As shown in XREF_FIG, LPS induced p65 nuclear translocation was significantly blocked in GRK5 -/- cells compared to GRK5 +/+ macrophages (XREF_FIG)."

20945396

---

➶

reach

"LPS induced secretion of TNF-alpha, IL-6, IL-1beta and NO was significantly attenuated in RelA and p65 Deltamye BMMPhis compared to WT (XREF_FIG)."

23562811

---

➶

reach

"Our results indicate a reduction of approximately 50% in the amounts of nuclear p65 in DC treated with DHA and LPS, and the reduction in p65 nuclear translocation correlates with DHA mediated IkappaB stabilization."

20122166

---

➶

reach

"Taken together, our results suggested that sauchinone could inhibit production of NO in LPS stimulated RAW264.7 cells through the suppression of NF-kappaB by inhibiting transactivation activity of RelA subunit."

14750024

---

➶

reach

"GILZ-p Inhibits LPS Induced NF-kappaB p65 Nuclear Translocation."

29681857

---

➶

reach

"XREF_BIBR, who demonstrated that Ni 2+ ions inhibited LPS induced p65 binding to DNA in a human monocyte cell line."

23844176

---

➶

reach

"The LPS induced p65 translocation was inhibited by EP treatment."

20026271

---

➶

reach

"Other flavonoids, quercetin and cyanidin, which lack alpha,beta-unsaturated carbonyl group, showed weaker or no inhibitory effect on both IL-6-induced STAT3 phosphorylation and LPS induced p65 translocation."

17320913

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➶

reach

"When p100 expression is high due to BCR stimulated RelA and cRel activity, the latter mechanism might lead to post-induction repression of cRel akin to IkappaBdelta mediated repression of lipopolysaccharide induced RelA activity in mouse embryonic fibroblasts (MEFs)."

25497099

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➶

reach

"Dipyrone and 2,5-dimethylcelecoxib suppressed LPS induced p65 and JNK MAPK (C-Jun N-terminal kinase mitogen activated protein kinase)."

25222785

---

➶

reach

"In addition, LPS induced p65 nuclear translocation was significantly suppressed by NOX4 siRNA."

27891092

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➶

reach

"Taken together, these results demonstrate that the induction of HO-1 has an inhibitory effect on LPS induced COX-2 expression through the attenuation of LPS induced p65 translocation."

24003391

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➶

reach

"This treatment pronouncedly alleviated LPS induced neuroinflammatory response, characterized by decreased 5LO, suppressed activation of microglia, decreased NF-kappaB p65, TNF-alpha and IL-1beta, and significantly increased the ratio of p-CREB and CREB or mBDNF and proBDNF in the hippocampus of the LPS challenged mice."

29174741

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➶

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"Finally, we report that news SERMs, ospemifene and bazedoxifene, exert anti-inflammatory actions by a mechanism involving classical estrogen receptors and by the inhibition of LPS induced NFkappaB p65 transactivation."

19533603

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➶

reach

"Moreover, the enhancement of stat3 phosphorylation and decrease of LPS induced p65 translocation were achieved by nicotine treatment."

28766689

---

➶

reach

"We conclude that LPS tolerance disrupts the transactivating stage of NF-kappaB p65 and altered nucleosome remodeling at the IL-1beta promoter in human leukocytes."

15972680

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➶

reach

"LPS also reduced cytoplasmic NF-kappaB p65 while elevated nuclear NF-kappaB p65 (P < 0.01, Figure XREF_FIG, XREF_FIG), indicating that LPS stimulated nuclear translocation of p65 and activated NF-kappaB signaling."

28415764

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➶

reach

"Inhibition of LPS induced NF-kappaB p65 nuclear translocation was confirmed by immunoblotting (data not shown)."

21257959

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➶

reach

"In fact, IkappaB kinase (IKK) assays showed that 1,25 (OH) 2 D 3 attenuated LPS induced IkappaBalpha phosphorylation in macrophages (XREF_FIG), which explains why 1,25 (OH) 2 D 3 stabilized IkappaBalpha protein reported previously, and immunostaining confirmed that 1,25 (OH) 2 D 3 blocked LPS induced p65 nuclear translocation RAW264.7 cells (XREF_FIG)."

23436936

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➶

reach

"We found that propofol treatment significantly (p < 0.05) reduced LPS induced NF-kappaB p65 nuclear translocation (47.3 +/-10.2 with LPS only vs. 17.1 +/-4.5 with LPS + propofol, XREF_FIG)."

21408125

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➶

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"By performing ChIP-qPCR on the selected IL-4-reduced p65 binding associated enhancers, we confirmed that IL-4-dependent reduction of LPS induced p65 binding was completely abolished in the absence of STAT6 (XREF_SUPPLEMENTARY B)."

29343442

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➶

reach

"Moreover, we elucidated that MBF-DE attenuated LPS induced inflammatory responses by blocking activation of both NF-kappaB and p65 and pERK and MAPK pathways."

26615818

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➶

reach

"PTX similarly decreased LPS induced NF-kappaB p65 nuclear phosphorylation, a marker of NF-kappaB activation and nuclear translocation (100 +/- 0 vs. 40 +/- 6; P = 0.03; XREF_FIG)."

18568240

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➶

reach

"LPS stimulated NF-kappaB p65 subunit nuclear translocation, visualized by immunofluorescence, was attenuated in both MS and T2DM subjects after MES+HS treatment (XREF_FIG C and XREF_FIG C)."

26137510

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➶

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"In our study, LPS induced degradation of IkappaB-alpha and NF-kappaBp65 nuclear localization in BMDCs from Wnt5aCAGDelta and Delta and Ror2 MxDelta and Delta mice, as well as BMDCs from control mice."

26030277

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➶

reach

"Our data revealed that LPS induced the up-regulation of ICAM-1, MCP-1 and TNF-alpha, LPS induced the down-regulation of PPARgamma, and LPS enhanced NF-kappaB p65 activation and DNA binding activity were substantially suppressed by emdoin in RAW264.7 cells."

26910236

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➶

reach

"However, LPS induced p65 translocation was significantly reduced in cells pre-treated with NRG-1 followed by LPS using ELISA and western blot."

27596278

---

➶

reach

"Curcusomes reduced the level of LPS induced nuclear p65 and RelA as assessed by immunofluorescence microscopy and p65 and RelA DNA binding activity by ELISA (XREF_FIG)."

21885868

---

➶

reach

"In addition, CME affected the RAW264.7 cell cycle and inhibited the protein expressions of COX-2 and NLRP3 and prevented the phosphorylation of NF-kappaB p65 in RAW264.7 cells treated with LPS."

30379164

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➶

reach

"Pre-treatment with oxymatrine followed by LPS stimulation resulted in a statistically significant reduction in LPS induced p65 nuclear accumulation compared to LPS-only treated cells (~ 40%; p < 0.01) (XREF_FIG)."

23568217

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➶

reach

"MS-275 inhibited LPS induced NF-kappaB p65 nuclear accumulation in human fibroblastic cells, gave rise to less acetylated NF-kappaB p65 in the nucleus, and reduced the secretion of pro inflammatory cytokines IL-6 and IL-18 XREF_BIBR."

28344354

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➶

reach

"Chromatin immunoprecipitation revealed that LPS challenge decreased p65, increased p50 and p52, and had no effect on RelB and c-Rel binding to kappaB elements of the AQP2 promoter."

18703515

---

➶

reach

"Moreover, both p65 nuclear translocation and NF-kappaB activity were promoted by lincRNA-p21 overexpression, while lincRNA-p21 inhibition showed a negative effect on LPS induced p65 nuclear translocation and increase of NF-kappaB activity."

32362153

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➶

reach

"Inhibitory effect of LZ-207 on LPS induced NF-kappaB p65 activation in THP-1 cells."

26023926

---

➶

reach

"In Study 102, LPS stimulated p65 activity was reduced for 5 of 8 subjects receiving 14 days of edasalonexent treatment (4000 mg daily) but not in 3 subjects receiving placebo."

28074489

---

➶

reach

"Deletion of SOCS3 had no effect on LPS induced NF-kappaB p65 and ERK1/2 activation, but enhanced LPS induced STAT1 and STAT3 activation (XREF_FIG)."

22925925

---

➶

reach

"The addition of LPS (100 ng/mL, 15 min) significantly increased and decreased the nuclear content of p50 and RelA and p50 and p50, respectively (XREF_FIG)."

25184316

---

➶

reach

"Pretreatment with KPG showed a decrease in LPS induced nuclear localization of the p65 subunit in a concentration dependent manner."

29470957

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➶

reach

"While our observations offer no single mode of action associated treatment, one can speculate that inhibition of NF-kappabeta activation and signaling is involved, which is supported by the observed suppression of LPS stimulated p65 in qPCR assays."

25843059

---

➶

reach

"Strikingly, RelA recruitment to target gene promoters was blocked when cells were treated with LPS in the presence of AICAR."

29773845

---

➶

reach

"LPS enhanced p65 nuclear translocation in macrophages; however, LPS induced p65 translocation was attenuated with the HO-1 activator CoPP (XREF_FIG)."

24003391

---

➶

ctd

No evidence text available

22363816

---

➶

reach

"However, it is unknown why there is only a partial inhibition of p120 on NF-kappaB activation and p65 was still found in nucleus in pEGFPp120 cells treated with LPS."

20172018

---

➶

reach

"Moreover, wedelolactone also inhibited LPS induced NF-kappaB p65 activation via the degradation and phosphorylation of IkappaB-alpha and subsequent translocation of the NF-kappaB p65 subunit to the nucleus [XREF_BIBR]."

27355071

---

➶

reach

"DMPO reduces LPS induced NF-kappaB p65 translocation and IkappaBalpha degradation."

22285597

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➶

reach

"Maximal inhibition of LPS induced NF-kappaB p65 activation was achieved with 11,12-EET, followed by 14,15-EET and 8,9-EET, indicating differential bioactivity of the different EET regioisomers, while all kinds of EETs had no obvious effect on LPS induced c-Rel activation."

25626689

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➶

reach

"A reduced expression of cytosolic IkappaB-alpha and NF-kappaBp65 was also observed when macrophages were treated with LPS alone or in combination with ASA."

25075522

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➶

reach

"We therefore conclude that type I parasites do not inhibit TNF- or LPS stimulated NF-kappaB p65 translocation or TNF stimulated NF-kappaB-mediated transcription, but they may be able to modulate other pathways or host cell transcription factors which are important for expression of a small subset of TNF stimulated genes."

21199955

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➶

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"However, while LPS treatment alone elevated p65 in both cytoplasmic and nuclear compartments, and pre-treatment with ghrelin and [D-Lys3]-GHRP-6 attenuated p65, there was no apparent alteration in the cytoplasmic to nuclear ratio to indicate regulation via p65."

23509933

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➶

reach

"We also found that Sirt7 deficiency in mouse aortic smooth muscle cells led to the suppression of lipopolysaccharide induced p65 nuclear accumulation (unpublished data)."

29651144

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➶

reach

"This observation was supported by another ChIP assay where LPS induced p65 recruitment on the same NF-kappaB RE of TNF-URR was significantly reduced by rosi treatment but not with cardiolipin (XREF_FIG, left panel)."

28074841

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➶

reach

"Since HDAC1 silencing exerts no significant effect on either miR-146a and miR-155 expression or redistribution of H3K4me3, it appears that LPS mediated NF-kappaB p65 and NF-kappaB p50 do not form repressor complexes with HDAC1."

24699235

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➶

reach

"To that end, it is worth nothing that though the use of a higher oxymatrine concentration in vitro resulted in an increased inhibition of LPS induced p65 nuclear translocation, this higher concentration was also associated with cellular toxicity."

23568217

---

➶

reach

"Inhibitory effect of acetylcorynoline on LPS induced NF-kappaB p65 translocation."

23472193

---

➶

reach

"Pretreatment with 6-MP had no inhibitory effects on LPS induced p65 DNA binding, indicating that 6-MP does not change the binding of p65 to the kappaB sites in an in vitro assay."

27075886

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➶

reach

"In our study of RAW264.7 cells, we suggested that the nuclear translocation of LPS induced NF-kappaB p65 was significantly inhibited by nicotine treatment, which may indicate the modulation of nicotine treatment on macrophages in ICM rat."

28928157

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➶

reach

"P53 inhibition in CAIA and LPS treated PARK2 KO mice increased p50 and p65 nuclear localization and NF-kappaB activation."

28395174

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➶

reach

"These data suggest that HMGB1 and LPS stimulation could downregulate the expression NF-kappaB p65 in cytoplasmic proteins and increase the expression in nuclear proteins, thus leading to modulation of IL-1beta, IL-10, IFN-gamma, and TGF-beta expression; moreover, the suppressive function of Treg cells could be regulated by TLR4."

28096525

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➶

reach

"While ATP levels were unchanged, the nuclear factor NF-kappaB (p65) activity was inhibited in Kupffer cells treated with MP after LPS stimulation (35.6 RLU versus 49.6 RLU in control)."

15840433

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➶

reach

"However, the same pattern was not observed in the siRNA group, in which LPS did not decrease cytoplasmic RelA but exhibited similar levels to the other siRNA groups."

28687727

---

➶

reach

"Our data indicate significant suppression of LPS induced NF-kappaB p65 nuclear translocation by the cAMP elevating metabolite synaptamide in microglia cells."

27809877

---

➶

reach

"Interestingly, fenofibrate resulted in a strong interaction between SHP and the NF-kappaB subunit p65, which was reduced by LPS stimulation (XREF_FIG)."

23704907

---

➶

reach

"In contrast, MS-275 was previously shown to inhibit LPS induced NF-kappaB p65 nuclear accumulation and acetylation XREF_BIBR."

28344354

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➶

reach

"LPS induced p65 binding was significantly reduced at 74 IL-4-repressed enhancers, while IL-4-repressed inflammatory response was not associated with modulated p65 binding at 374 enhancers (XREF_FIG E and 6F)."

29343442

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➶

reach

"This hypothesis was supported by our results indicating that LPS induced NF-kappaB p65 activation in GC cell was reversed when the cell was incubated with DPI (XREF_FIG)."

24030146

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➶

ctd

No evidence text available

21948866

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➶

reach

"Naloxone and methylprednisolone significantly reduced the LPS induced increase in IL-8 concentrations in serum in vivo, and suppressed the activation of NF-kappaB p65 in the lung tissue."

15970107

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➶

reach

"EF inhibited the LPS induced NF-kappaB p65 (LPS+EF 20mug/mL and 30mug/mL vs. LPS only : 0.78 +/-0.06 vs. 1.17 +/-0.08, P < 0.001; and 0.90 +/-0.06 vs. 1.17 +/-0.08, P = 0.002) and inhibitor of kappa B (IkappaBalpha) phosphorylation (LPS+EF 20mug/mL and 30mug/mL vs. LPS only : 0.25 +/-0.01 vs. 0.63 +/-0.03, P < 0.001; and 0.31 +/-0.01 vs. 0.63 +/-0.03, P < 0.001), LPS+EF 30mug/mL inhibited IkappaB kinase (IKKalpha and beta) phosphorylation (LPS+EF 30mug/mL vs. LPS only, 1.12 +/-0.14 vs. 1.71 +/-0.25, P = 0.002) in RAW 264.7 cells."

30681498

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➶

reach

"Our data suggest that HMGB1 and LPS stimulation could downregulate the expression NF-kappaB p65 in cytoplasmic protein and increase it in nuclear protein, thus leading to modulation of IL-1beta, IL-10, IFN-gamma, and TGF-beta expression."

28096525

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➶

reach

"It was observed that LQJD reduced the LPS induced body temperature, inflammatory cytokines level, and lung injuries, and blocked the activation of TLR4 and NF-kappaBp 65 signaling in lung tissue."

28972887

---

➶

reach

"Using chromatin immunoprecipitation, we demonstrate that LPS induced RelA recruitment to the ICAM-1 gene promoter is significantly reduced in luteolin treated cells."

15946255

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➶

reach

"PITC inhibited LPS induced IkappaBalpha phosphorylation and degradation and subsequently reduced LPS induced p65 nuclear translocation and the transcriptional activity of nuclear factor-kappaB (NF-kappaB), which was accompanied by a reduction in ERK1/2 and AKT phosphorylation."

21303260

---

➶

reach

"Chromatin immunoprecipitation analysis revealed that B. vulgatus and LPS induced RelA recruitment to the IL-6 promoter is inhibited by TGF-beta1 treatment."

12672795

---

➶

reach

"Inhibition of LPS induced nuclear localization of p65 by ATF3."

26412238

---

➶

reach

"We found that treatment with propofol significantly (p < 0.05) inhibited LPS induced NF-kappaB p65 nuclear translocation (56.7 +/-11.3 with LPS only vs. 17.7 +/-10.1 with LPS + propofol, XREF_FIG)."

21408125

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➶

reach

"Inhibition of LPS induced p65 translocation has been reported in human monocytes treated with ethanol in vitro, but decreased phosphorylation of p65 (which was not assessed in the present study) was found to be more important [XREF_BIBR]."

19765273

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➶

reach

"Co-incubation with MaR1 (10 nM) significantly attenuated LPS induced NF-kappaB p65 nuclear translocation in BMDMs [nuclear p65 + cells : 16 (3)%, P < 0.01 vs LPS group, XREF_FIG a and b], and partly reduced TNF-alpha levels in the culture medium [494 (49) pg ml -1, P = 0.01 vs LPS group; XREF_FIG c]."

30770053

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➶

reach

"Suppression of LPS stimulated NF-kappaB p65 and JNK activation by BPs in macrophages."

24167596

---

➶

reach

"Further, while NF-kappaB p50 +/+ mice exhibited an LPS induced increase in brain NF-kappaB p65 DNA binding in both young and aging mice, the NF-kappaB p50 -/- mice revealed a decrease in LPS induced NF-kappaB p65 DNA binding, regardless of age."

30871598

---

➶

reach

"Curcusomes reduced the level of LPS induced nuclear p65 and RelA as assessed by immunofluorescence microscopy and p65 and RelA DNA binding activity by ELISA (XREF_FIG)."

21885868

---

➶

reach

"EGFR inhibition promoted LPS stimulated NF-kappaB p65 nuclear translocation (XREF_FIG)."

24391216

---

➶

reach

"Chromatin immunoprecipitation assay demonstrated that LPS induced RelA recruitment to the ICAM-1 gene promoter was inhibited by SME."

15996193

---

➶

reach

"Moreover, both basal and LPS induced NF-kappaBp65 activity was significantly reduced following exposure to acrolein compared with exposure to room air."

18566440

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➶

reach

"PDTC Diminished LPS Induced NF-kappaB p65 Activity in the Hippocampus."

27493629

---

➶

reach

"LPS up-regulated p65 was dramatically inhibited at 3 h, but was enhanced at 6 h by SFN pre-incubation in porcine moDCs (XREF_FIG)."

25793534

---

➶

reach

"A decrease of cytosolic IkappaB-alpha expression and increased nuclear translocation of NF-kappaBp65 was also observed when HepG2 cells were treated with LPS alone or in combination with ASA."

27441638

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➶

reach

"LPS induced secretion of TNF-alpha, IL-6, IL-1beta and NO was significantly attenuated in RelA and p65 Deltamye BMMPhis compared to WT (XREF_FIG)."

23562811

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➶

reach

"Remarkably, total NF-kappaB p65 protein content was significantly reduced by 30% in LPS and IFNgamma stimulated RAW264.7 macrophages treated with MS-275 (XREF_FIG)."

28344354

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➶

reach

"Inhibitory effect of LZ-207 on LPS induced NF-kappaB p65 activation in HCT116 cells."

26023926

Anthra[1,9-cd]pyrazol-6(2H)-one affects MAPK8

1 7 | 49 10 21

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits MAPK8. 88 / 88

1 7 | 49 10 21

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➶

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"JNK1 can be inhibited by the anthrapyrazole SP600125 (XREF_TABLE), even though this compound also mildly impairs the function of p38beta and ERK2 [XREF_BIBR]."

26516076

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➶

medscan

"SP600125, a specific c-Jun N-terminal kinase (JNK) inhibitor, inhibited the effect of IL-1beta."

15677771

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➶

sparser

"SP600125 inhibits JNK1, JNK2, and JNK3 with a high specificity and markedly inhibits the activation/phosphorylation of c -Jun as well as expression of inflammatory genes xref ."

25428720

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➶

tas

No evidence text available

20146479

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➶

medscan

"Inhibition of basal JNK activity by JNK inhibitor SP600125 or JNK1siRNA repressed presenilin-1 (PS1) expression in SK-N-SH cells by augmenting the level of p53, a repressor of the PS1 gene (1)."

20036849

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➶

sparser

"Since JNK-1 is required for the development of bone resorption activity by osteoclasts, the inhibition of bone resorption may be related to JNK-1 inhibition by SP600125 in vivo ."

20165551

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➶

medscan

"The activation of these elements was not affected by preincubation of cells with N-acetyl-cysteine , L: -buthionine-(S,R)-sulfoximine (BSO), and c-Jun N-terminal kinase (JNK) inhibitor (SP600125), suggesting that activation of CHOP promoter by brefeldin A may not involve oxidative stress or JNK signaling pathway."

18679584

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➶

medscan

"Immunofluorescence analysis showed that TGF-beta(1) stimulated the activation of JNK1/2 and induced cell migration, effects that were inhibited by SP600125."

19589256

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➶

tas

No evidence text available

---

➶

medscan

"This effect was strongly attenuated by the specific JNK inhibitor SP600125, which blocks the kinase activity of JNK and results in reduced p-JNK1 levels."

19276385

---

➶

signor

"We report the identification of an anthrapyrazolone series with significant jnk1, -2, and -3 (k(i) = 0.19 microm)."

11717429

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➶

medscan

"The inhibition of c-jun N-terminal kinase (JNK) by SP600125, a specific JNK inhibitor, decreased the expression of Major vault protein and specificity protein 1 under hyperosmotic conditions."

23820674

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➶

reach

"Furthermore, inhibition of JNK1 by SP600125 promoted Epo withdrawal induced apoptosis (XREF_FIG)."

21095239

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➶

medscan

"In contrast, Mrp1 functional expression was not altered in the presence of gp120 or TNF-alpha when astrocyte cultures were pretreated with 1,9-pyrazoloanthrone (SP600125), an established c-Jun N-terminal kinase (JNK) inhibitor."

20051532

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➶

sparser

"SP600125 inhibits JNK1, JNK2, and JNK3 with similar potencies ( xref )."

18651635

---

➶

reach

"Alcohol activates JNK1 to upregulate transcription of Brf1 and Pol III genes, whereas inhibition of JNK1 by SP600125 or its siRNA significantly decreases the induction of these genes."

28552569

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➶

reach

"A -smooth muscle cells were starved in serum-and growth factor-free medium for 18 h and then pretreated with SP600125 (SP) to inhibit JNK1 or PD98059 (PD) to inhibit MEK1 for 45 min."

18373239

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➶

medscan

"The up-regulation of GADD45α was abolished by pretreatment with the c-Jun N-terminal kinases (JNK) inhibitor SP600125 but not the p38 specific inhibitor SB203580."

25469469

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➶

medscan

"endometrial stromal cells were obtained from 16 control women (normal) and 14 patients with ovarian endometrioma, then the normal endometrial stromal cells were treated with plasmid pEGFP-N1-IDO1 or SD11-IDO1 short hairpin RNA alone, or in combination with c-Jun N-terminal kinase (JNK) inhibitor (SP600125), and subjected to cell viability, proliferation, apoptosis assay and Matrigel invasion assay."

23411497

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➶

medscan

"Accordingly, dephosphorylation of c-Jun and SP1 by the specific c-Jun N-terminal kinase (JNK) inhibitor SP600125 prevented the increase in TGFβ1 expression."

27112839

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➶

medscan

"SB203580 acts as an inhibitor of the p38 signalling pathway, while SP600125 inhibits the JNK pathway, suppressing IL-17A-induced mitogen-activated protein kinase activation and COX2 expression.Fig. 7Schematic model of the proposed signal pathways of inflammation induced by IL-17A In our study, p38-mitogen-activated protein kinase and JNK-mitogen-activated protein kinase inhibition significantly reduced the induction of COX2 expression by IL-17A."

26988982

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➶

sparser

"SP600125 is an anthrapyrazolone capable of inhibiting JNK1, JNK2, and JNK3 with high affinity ( xref , xref )."

30444263

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➶

medscan

"Moreover, inhibition of JNK pathway by SP600125 blocks autophagy activation and p62 degradation induced by knockdown of DJ-1."

20510502

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➶

reach

"We found that the up-regulated level of Netrin-1 and its receptor DCC promoted axonal regeneration and synaptic formation; the overexpression of Netrin-1 activated the JNK1 signaling pathway; these effects were partially reduced when JNK1 signaling pathway was inhibited by SP600125 (JNK specific inhibitor)."

29487502

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➶

medscan

"Constitutive and HGF-induced Hic-5 expression in hepatocellular carcinomas were suppressed by the reactive oxygen species scavengers catalase and dithiotheritol and c-Jun N-terminal kinase (JNK) inhibitor SP600125."

26416447

---

➶

medscan

"IL-18-enhanced TSP-1 expression was blocked by SP600125, a c-Jun N-terminal kinase (JNK) specific inhibitor."

16650813

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➶

reach

"JNK1 activity was suppressed in rats by SP600125 treatment (XREF_FIG)."

27909723

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➶

tas

No evidence text available

25415535

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➶

medscan

"We cultured human keratinocytes of the HaCaT cell line and investigated both mRNA and protein expressions of cytokines in cells that were not irradiated or were exposed to 2.4 J/cm(2) UVA, with or without an antioxidant (beta-carotene) or a c-Jun N-terminal kinase (JNK) inhibitor (SP600125)."

20070836

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➶

medscan

"Moreover, treatment of Major vault protein knocked-down senescent human diploid fibroblasts with SP600125, a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, restored the level of Bcl-2 protein."

18600231

---

➶

tas

No evidence text available

18077363

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➶

medscan

"Accordingly, inhibition of SAPK/JNK pathway using SP600125 increased apoptosis of K562 cells in presence of imatinib."

24098519

---

➶

medscan

"Furthermore, blocking MEK/Erk signalling with specific extracellular signal-regulated protein kinases 1 and 2 inhibitor PD98059, or JNK signalling with specific inhibitor SP600125, abolished effects of EREG on cell proliferation."

23829318

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➶

medscan

"These changes were abrogated through c-Jun NH(2) kinase (JNK) chemical inhibitor (SP600125) or JNK2 siRNA."

19176398

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➶

reach

"As shown in XREF_FIG (MTT assay) and XREF_FIG (annexin-V and PI double staining), SP600125 (an inhibitor of JNK-1, -2 and -3), SB202190 (an inhibitor of p38 MAPK-beta), and U0126 (an inhibitor of MEK1/2) each significantly reduced glutamate induced cell death in a concentration dependent manner."

20542495

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➶

reach

"SB, but not SP, was very effective in lowering the activation of p38 MAPK produced by AA plus 3-MA to below basal levels (XREF_FIG B and C; lanes 3 and 4) while SP, but not SB, effectively blocked the 2-3 fold elevated ratio of pJNK1 and JNK1 to below basal levels (XREF_FIG D and E : lanes 3 and 5), validating their specific inhibitory effectiveness."

24273738

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➶

medscan

"However, the receptor for advanced glycation end products (RAGE) blocker RAGE-Ab (5 μg/ml) or 10 μM c-Jun N-terminal kinases (JNK) inhibitor SP600125 could inhibit HMGB1-induced the release of inflammation cytokines including TNF-α, IL-8, IL-10, and MCP-1 in a dose-dependent manner."

23712703

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➶

medscan

"Treatment with the NF-kappaB inhibitor Helenalin as well as with the c-Jun N-terminal kinase (JNK) inhibitor SP600125 and the p38 mitogen-activated protein kinase inhibitor SB 202190 blocked hBD-2 induction by IL-1beta and Pseudomonas aeruginosa."

16417227

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➶

medscan

"SP600125, a potent JNK1 inhibitor, reduces the JNK1 activity associated with GLUT4 and the phosphorylation of two minor GLUT4 species in serum-starved 3T3-L1 adipocytes."

18932217

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➶

medscan

"The Akt inhibitor API-2 and the c-Jun N-terminal kinase (JNK) inhibitor SP600125 selectively inhibited insulin regulation of CIDEA and CIDEC expression, respectively, whereas the MAPK/ERK kinase inhibitor U0126 and the p38 inhibitor SB203580 did not."

21636835

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➶

medscan

"Inhibition of basal c-jun-NH2-terminal kinase (JNK) activity by JNK inhibitor SP600125 repressed PS1 transcription and PS1 protein expression by augmenting p53 protein level in SK-N-SH cells (Lee and Das 2008)."

22607268

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➶

reach

"Additionally, in MPHs isolated from Jnk1 -/- and Jnk2 -/- mice, the response of nuclear RXRalpha to IL-1beta could only be inhibited by complete abrogation of JNK activation by pretreatment of SP600125 but not in the hepatocytes lacking each individual Jnk1 or Jnk2 gene (XREF_FIG)."

19767119

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➶

medscan

"SB203580 [4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl) 1 H-imidazole; Calbiochem] directly inhibits the activation of p38 mitogen-activated protein kinase, and SP600125 (1,9-Pyrazoloanthrone; Calbiochem) preferentially inhibits anti-c-Jun N-terminal kinase 1/2."

26323834

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➶

sparser

"As SP600125 inhibits both JNK1 and JNK2, to further evaluate the relationship between JNK2 and the UPR, BiP and CHOP were analyzed by western blot after JNK2 silencing."

23171849

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➶

reach

"The JNK specific inhibitor; SP600125 also inhibited JNK1 activation."

26928204

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➶

medscan

"In addition, the transcriptional activity of hST3Gal V induced by valproic acid in ARPE-19 cells was inhibited by SP600125, a c-Jun N-terminal kinase (JNK) inhibitor."

21699754

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➶

reach

"As SP600125 inhibits both JNK1 and JNK2, to further evaluate the relationship between JNK2 and the UPR, BiP and CHOP were analyzed by western blot after JNK2 silencing."

23171849

---

➶

medscan

"Addition of c-jun N-terminal kinase (JNK) inhibitor SP600125 and interferon-γ (IFN-γ) antibody 30 min before stretch inhibited PUMA expression."

22021910

---

➶

medscan

"Treatment with an MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase] inhibitor (PD98059) and a JNK (c-Jun N-terminal kinase) inhibitor (SP600125) suppresses PMA-induced MD-2 gene expression, whereas impairment of p38 function by treatment with the inhibitor SB203580 has no effect on MD-2 mRNA."

18181766

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reach

"The H 2 O 2 levels could be decreased by pcDNA3 (FLAG)-JNK1-wt transfection in A2780 and DDP cells and this effect could be counteracted by a JNK1 antagonist SP600125."

16105650

---

➶

medscan

"The transforming growth factor-α-induced cell migration was inhibited by SP600125, a c-Jun N-terminal kinases (JNK) inhibitor."

27046040

---

➶

medscan

"The JNK activity specific inhibitor, SP600125, and siRNA directed against JNK were used to block JNK/c-Jun pathway."

21943220

---

➶

sparser

"Importantly, inhibition of JNK1 by SP600125 blocked the reduction of apoptotic cell number ( xref ) and apoptotic markers (i.e., cleavage of caspase-3 and PARP) caused by metformin ( xref )."

23223177

---

➶

medscan

"Moreover, the transcription of hST8Sia VI induced by physcion in SK-N-BE(2)-C cells was inhibited by extracellular signal-regulated protein kinase (ERK) inhibitor U0126 and p38 mitogen-activated protein kinase inhibitor SB203580, but not c-Jun N-terminal kinase (JNK) inhibitor SP600125."

27490539

---

➶

medscan

"Using synchronized cells, we show that the c-Jun N-terminal kinase (JNK) inhibitor, SP600125, prevents the entry of cells into mitosis and leads to endoreplication of DNA from G2 phase."

20062077

---

➶

medscan

"Using HER2-positve gastric cancer cell lines SNU-216 and NCI-N87, HER2 expression was silenced by RNA interference, and the activations of JNK and AKT were suppressed by SP600125 and LY294002, respectively."

27895401

---

➶

medscan

"In this study, we showed that the hepatitis C virus-induced activation and mitochondrial accumulation of Bax were significantly attenuated by treatment with a general antioxidant, N-acetyl cysteine , or a specific c-Jun N-terminal kinase (JNK) inhibitor, SP600125, with the result suggesting that the reactive oxygen species /JNK signalling pathway is upstream of Bax activation in hepatitis C virus-induced apoptosis."

26296767

---

➶

medscan

"Treatment with the JNK inhibitor SP600125 and silencing of both JNK1 and JNK2 with siRNA inhibited ultrafine particles-stimulated O(2)(-) production and mRNA expression of HO-1 and tissue factor."

19154785

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➶

reach

"Importantly, inhibition of JNK1 by SP600125 blocked the reduction of apoptotic cell number (XREF_FIG) and apoptotic markers (i.e., cleavage of caspase-3 and PARP) caused by metformin (XREF_FIG)."

23223177

---

➶

reach

"Meanwhile, c-jun activity was significant attenuated by SP600125 or after transfection with the JNK1 siRNA in XREF_FIG."

22870247

---

➶

medscan

"Our data showed that extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059, but not the c-Jun N-terminal kinase (JNK) inhibitor SP600125, p38 kinase inhibitor SB203580, and PI3K inhibitor wortmannin, attenuated Src-induced MMP-2 promoter activity."

16453304

---

➶

sparser

"SP600125 inhibits the JNK1, -2, and -3 pathways [ xref ]."

23861561

---

➶

reach

"SP600125 inhibits the JNK1, -2, and -3 pathways [XREF_BIBR]."

23861561

---

➶

medscan

"Among signaling inhibitors, a c-Jun NH(2)-terminal kinase (JNK) inhibitor (SP600125) markedly attenuated dynasore-stimulated PAI-1 protein production."

18978303

---

➶

reach

"SP600125 inhibits JNK1, JNK2, and JNK3 with similar potencies."

18651635

---

➶

medscan

"The anti-cancer effect of the c-Jun N-terminal kinase (JNK) inhibitor SP600125 has been well evaluated in human cancer cells."

21311948

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➶

tas

No evidence text available

18313304

---

➶

medscan

"Inhibition of JNK/c-jun pathway with its inhibitor SP600125 reversed the phosphorylation of c-jun and the activation of caspase-3 induced by co-treatment of HuH-7 cells with melatonin and sorafenib in a dose-dependent manner."

28178378

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➶

sparser

"Hence, inhibition of JNK1 and JNK2 by SP600125 reduces the expression of these transcription factors and cell cycle genes, thereby reducing cell proliferation."

24847381

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➶

medscan

"Because phosphorylation of cdc2 and upregulation of wee1 by 2-ME(2) can be abolished by both extracellular receptor kinase (ERK) inhibitor (U0126) and c-Jun N-terminal kinase (JNK) inhibitor (SP600125), our studies indicate that the 2-ME(2)-induced upregulation of wee1 and subsequent cdc2 phosphorylation are mediated through mitogen-activated protein kinase -ERK-JNK signaling pathways."

16533053

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➶

reach

"SB203580 (an inhibitor of p38 MAPK; 10microM), PD98059 (an inhibitor of ERK2; 20microM), and SP600125 (an inhibitor of JNK1; 10microM) markedly inhibited p38 MAPK (XREF_FIG), ERK2 (XREF_FIG), and JNK1 (XREF_FIG) phosphorylation in collagen activated platelets, respectively."

29853830

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➶

reach

"A -smooth muscle cells were starved in serum-and growth factor-free medium for 18 h and then pretreated with SP600125 (SP) to inhibit JNK1 or PD98059 (PD) to inhibit MEK1 for 45 min."

18373239

---

➶

tas

No evidence text available

21815634

---

➶

medscan

"Inhibition of c-jun N-terminal kinase (JNK) by SP600125, p38 by SB 203580, or tyrosine kinase by genistein reduced arecoline-induced Hemeoxygenase-1 expression."

21889036

---

➶

medscan

"The effect of the pan c-Jun N-terminal kinase (JNK) inhibitor SP600125 on the proliferation of human lung carcinoma A549 cells has been evaluated."

17904874

---

➶

reach

"Furthermore, SP600125 was used to inhibit the potential downstream factor JNK1, and the osteogenic differentiation ability of DPSCs was evaluated."

30972205

---

➶

reach

"SP600125, a potent JNK1 inhibitor, reduces the JNK1 activity associated with GLUT4 and the phosphorylation of two minor GLUT4 species in serum starved 3T3-L1 adipocytes."

18932217

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➶

sparser

"SP600125 is an anthrapyrazolone capable of inhibiting JNK1, JNK2, and JNK3 with high affinity [ xref ]."

26914092

---

➶

medscan

"Pretreatment with 50 nmol/L of c-Jun N-terminal kinases (JNK) inhibitor SP600125 abolished the upregulation of GADD34. c-Jun silencing by transfection with c-Jun small-interfering RNA abolished the effects of Aβ1-42 on the expression of GADD34."

25204313

---

➶

medscan

"In this study, we show that the suppression of Jun N-terminal kinase (JNK) by the JNK inhibitor SP600125 or short-hairpin RNA inhibited podosome rosette formation in SrcY527F-transformed NIH3T3 fibroblasts."

24127566

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➶

reach

"JNK1 can be inhibited by the anthrapyrazole SP600125, even though this compound also mildly impairs the function of p38beta and ERK2 [XREF_BIBR]."

26516076

---

➶

medscan

"Furthermore we determined the added effect of Src or JNK inhibition by PP2 and SP600125, respectively, on chemotherapeutic response."

26049416

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➶

sparser

"TGFβ also induced phosphorylation of (S351) NR4A1, JNK1, c-jun and c-fos which was also inhibited by SP600125, demonstrating that TGFβ induces JNK and genes downstream from JNK."

30072581

---

➶

tas

No evidence text available

15711537

---

➶

medscan

"Treatment with JNK inhibitor SP600125 and silencing of both JNK1 and JNK2 with siRNA inhibited ultra fine particles stimulated O2·- production and mRNA expression of hemeoxygenase-1 and TF."

19154785

---

➶

medscan

"SP600125 inhibits Jun N-terminal Kinase kinase activity by competing with ATP for its binding site."

22911848

---

➶

medscan

"Suppression of Tgase-2 or the c-Jun-N-terminal kinase (JNK) inhibitor, SP600125, significantly reduced and over-expression of Tgase-2 increased the expression of N-cadherin."

23290789

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➶

medscan

"SP600125 and PD98059 were used to block the activation of c-Jun terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) respectively."

21131736

Glyburide affects NLRP3

| 85

Glyburide inhibits NLRP3. 85 / 85

| 85

---

➶

reach

"This study revealed that glyburide inhibits NLRP3 inflammasome activation by various stimuli, thereby preventing secretion of IL-1beta [XREF_BIBR]."

20861596

---

➶

reach

"Glyburide and fluoxetine impeded activation of NLRP3 inflammasome in pancreas by suppressing upstream molecule TXNIP."

29084550

---

➶

reach

"For example, Glyburide can inhibit NLRP3 inflammasome mediated caspase-1 activation and both IL-1beta and IL-18 release 15."

22430788

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➶

reach

"To explore whether N. caninum also induced NLRP3 inflammasome activation via K + efflux, glyburide, which inhibits the NLRP3 inflammasome by inhibiting K + efflux, was added to BMDMs."

30105037

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➶

reach

"An interesting point in the relationship between inflammasome and metabolism is that glyburide, a well-known drug of sulfonylurea class for type 2 diabetes inhibits NLRP3 stimulation, which is independent of its effect on ATP sensitive K ATP channel."

21637386

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➶

reach

"To further validate the role of NLRP3 inflammasome during HS induced cellular responses, cells were co-cultured with the NLRP3 antagonist glyburide or the caspase-1 specific inhibitor YVAD."

30611121

---

➶

reach

"NOD like receptor protein-3 (NLRP-3) is pro inflammatory in the kidney; glibenclamide inhibits production of NLRP-3."

24291534

---

➶

reach

"In this study, we show that the type 2 diabetes drug glyburide prevented activation of the Cryopyrin inflammasome."

19805629

---

➶

reach

"Glyburide inhibits the Cryopyrin inflammasome downstream of the P2X 7 receptor."

19805629

---

➶

reach

"The use of glibenclamide and interference plasmids to inhibit NLRP3 inflammasome activation revealed that the number of CSFV virus gene copies and the virus titer after 24 and 48 h increased following CSFV infection in PBMCs, indicating that NLRP3 had a negative effect on CSFV replication."

30013955

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➶

reach

"Glyburide appears to inhibit the NLRP3 inflammasome and the subsequent IL-1β activation in macrophages."

32445957

---

➶

reach

"Lamkanfi et al. demonstrated that glyburide is able to inhibit assembly of the NLRP3 inflammasome in response to stimulation with lipopolysaccharide (LPS) and adenosine triphosphate (ATP) XREF_BIBR."

24147174

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➶

reach

"Glyburide was shown to inhibit the ATPase activity of NLRP3, but it is unclear whether other drugs from this class can act in a similar manner, and if this observation is related to the glyburide mediated inhibition of inflammasome formation."

27508077

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➶

reach

"It was reported that glyburide prevents Nlrp3 inflammasome activation in vitro; XREF_BIBR however, the effects of GLP-1 receptor activation on the Nlrp3 inflammasome has not been reported before."

27547413

---

➶

reach

"Antioxidants and glyburide block upstream signaling of the NLRP3 inflammasome in vitro."

25596299

---

➶

reach

"Glyburide, a drug commonly used in type 2 diabetes, can also prevent NLRP3 dependent IL-1beta production [XREF_BIBR]."

28192528

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➶

reach

"Glibenclamide inhibited NLRP3 inflammasome via upstream inhibition of the inflammasome and downstream blockade of the P2X7 receptor, which then reduced NLRP3 inflammasome mediated caspase-1 activation and inhibited the maturation of IL-1beta [XREF_BIBR]."

29178967

---

➶

reach

"Glyburide and parthenolide both inhibited NLRP3 activation by LPS and ATP (data not shown)."

22216309

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➶

reach

"Compound glyburide, which is known to inhibit NLRP3 function, blocked IL-1beta production because of M. tuberculosis and M. tuberculosis promoted necrosis (XREF_FIG)."

21740493

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➶

reach

"Glyburide and YVAD significantly inhibited the activation of NLRP3 inflammasome and the production of IL-1beta stimulated by anti-dsDNA antibodies."

27250627

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➶

reach

"To investigate the role of the NLRP3 inflammasome in LPS induced IL-1beta production by the CFs, the cells were transfected with siRNA, which was specific for NLRP3, or CFs were pretreated with glyburide (an inhibitor of NLRP3 inflammasomes) prior to the LPS challenge XREF_BIBR."

25216263

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➶

reach

"Similar results were obtained when glyburide instead of CASP1 inhibitor was used to block NLRP3 inflammasome XREF_BIBR, XREF_BIBR."

32332867

---

➶

reach

"Glyburide, which specifically inhibits NLPR3 inflammasome activation [XREF_BIBR], was used to inhibit NLRP3, and capase-1 inhibitor YVAD was used to inhibit caspase-1."

27250627

---

➶

reach

"Interestingly, glibenclamide (also known as glyburide), a diabetes drug proposed as a novel treatment for acute brain injury due to its ability to inhibit the Sur1-Trpm4 channel involved in brain edema [XREF_BIBR], was also shown to inhibit the NLRP3 inflammasome [XREF_BIBR]."

25091898

---

➶

reach

"Glibenclamide decreased infiltration of chronic inflammatory cells, fibrosis, tubular damage and expression of HO-1, TNF-alpha and NLRP-3 in the kidney."

24291534

---

➶

reach

"Glyburide, a K + channel blocker, also inhibited NLRP3 inflammasome in vitro, which appears to confirm the role of K + efflux."

29892295

---

➶

reach

"Glyburide inhibits the Cryopyrin and Nalp3 inflammasome."

19805629

---

➶

reach

"Glibenclamide Might Inhibit the Activation of NLRP3 Inflammasome."

28740332

---

➶

reach

"Glyburide appears to inhibit the NLRP3 inflammasome and the subsequent IL-1activation in macrophages."

32445957

---

➶

reach

"To determine whether NLRP3 inflammasome is involved in islet cell death induced by hypoxia, NLRP3 inflammasome was inhibited by glyburide under hypoxia and cell death analyzed."

29941940

---

➶

reach

"The sulfonylurea drug glyburide, usually used clinically to treat type II diabetes, is a non selective antagonist of NALP3 and could prevent activation of the NALP3 inflammasome and crystal induced IL-1beta secretion."

30186184

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➶

reach

"Glibenclamide inhibited NLRP3 inflammasome activation and subsequently protected against organ inflammation and tissue damage either in a cerulean induced obese mouse model of SAP, or in an adenine-diet rat model of chronic kidney disease, or in a cyclophosphamide induced rat model of bladder inflammation, or in a lipopolysaccharide induced myocardial injury in streptozocin induced diabetic rats [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."

28740332

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➶

reach

"NOD2 stimulation by systemic administration of muramyl dipeptide appears to be beneficial in mouse models of colitis.123 Glyburide (glibenclamide), a sulfonylurea drug for the treatment of type 2 diabetes, is known to inhibit ATP-sensitive K+ channels and thus can prevent NLRP3 inflammasome activation.124 Glyburide has been shown to prevent ventilator-induced lung injury in mice and delay endotoxin-induced lethality in mice, but it has not been applied for animal models of colitis.124, 125PRR signaling has significant roles in intestinal homeostasis, which is mainly composed of the maintenance of commensals."

23515136

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➶

reach

"In addition, the anti-diabetic drug glyburide can inhibits NLRP3 and therefore may function partially via ani-inflammatory mechanisms."

23068074

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➶

reach

"NLRP3 inflammasome signaling pathway was augmented by LPS but suppressed by glyburide."

27614764

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➶

reach

"Finally, specific FDA approved reagents that inhibit molecules involved in asbestos induced inflammation are available : anakinra, an IL-1beta receptor antagonist; infliximab, a chimeric human-mouse anti-TNF-alpha; etanercept, a soluble TNF receptor fusion protein; glyburide, that inhibits the NALP3 inflammasome [XREF_BIBR]."

26308799

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➶

reach

"Finally, we treated monocytes and MDC with 100 muM glibenclamide, a sulfonylurea drug which inhibits NLRP3 activation but not NLRC4 activation [XREF_BIBR]."

28081233

---

➶

reach

"Likewise, a sulfonylurea drug Glyburide which is widely used for the treatment of Diabetes type 2, was also shown to inhibit the NLRP3 inflammasome."

32574259

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➶

reach

"This can be explained by the fact that Nlrp3 inflammasome inhibition by glibenclamide was only partial, as residual amounts of IL-1beta and cleaved caspase-1 were still detectable in myeloid cells (unpublished data)."

23980097

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➶

reach

"Similar to RIPK3 dependent IL-1beta activation in caspase-8 or IAP depleted macrophages, the caspase-1 and IL-1beta secretion (but not TNF secretion) observed in LPS treated Ripk1 -/- FLDMs was abrogated by glyburide inhibition of NLRP3 (XREF_FIG)."

25693118

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➶

reach

"Collectively, these results demonstrate that glyburide acts upstream of Cryopyrin and downstream of the P2X 7 receptor to block Cryopyrin dependent inflammasome activation by PAMPs, DAMPs, and crystalline substances."

19805629

---

➶

reach

"Our results are in agreement with the study of Tschopp et al., who showed that NLRP3 inflammasome is expressed and inhibited by glyburide in murine islet cells 20."

29941940

---

➶

reach

"In fact, glyburide, which is used in the treatment of T2D, was found to inhibit NLRP3 inflammasome activity."

23276949

---

➶

reach

"Glibenclamide (GLB), a sulphonylurea drug used to treat type II diabetes, possesses anti-inflammatory properties and inhibits NLRP3 inflammasomes."

31761320

---

➶

reach

"Furthermore, glyburide impedes PAMP, DAMP, and crystal mediated NLRP3 inflammasome activation in bone marrow derived macrophages [XREF_BIBR]."

32693241

---

➶

reach

"Glyburide appears to inhibit the NLRP3 inflammasome and the subsequent IL-1β activation in macrophages (178)."

32445957

---

➶

reach

"In our study, we chose glibenclamide not only because of its protective role in neurological diseases by inhibiting K ATP channels, but also because that glibenclamide could abolish the activation of NLRP3 inflammasome in bone marrow derived macrophages (BMDMs) [XREF_BIBR], although the exact mechanism was not fully understood."

29178967

---

➶

reach

"Glyburide appears to inhibit the NLRP3 inflammasome and the subsequent IL 1betaactivation in macrophages."

32445957

---

➶

reach

"Additionally, glibenclamide inhibited NLRP3 and caspase-1 expression [XREF_BIBR]."

28740332

---

➶

reach

"Glyburide (glibenclamide), a sulfonylurea drug for the treatment of type 2 diabetes, is known to inhibit ATP sensitive K+ channels and thus can prevent NLRP3 inflammasome activation."

23515136

---

➶

reach

"For inhibitor experiments, glyburide (100 mumol/L) and Z-YVAD-FMK (2 mumol/L) were added 30 minutes before PM 10 exposure to inhibit the NLRP3 inflammasome 38 or caspase-1, respectively."

22227418

---

➶

reach

"Primarily acting by blocking the ATP sensitive K + channels (K ATP) in beta-cells of the pancreas, Glyburide was shown to act upstream and prevent NLRP3 inflammasome activation."

32574259

---

➶

reach

"Glibenclamide abolished inflammasome activation in macrophages lacking K ATP channel subunits as well [XREF_BIBR]."

28740332

---

➶

reach

"In summary, XREF_FIG provides two important pieces of information : first, that the NLRP3 inflammasome is more active in obese mice, as indicated by a more robust IL-1beta response; and second, that glyburide effectively inhibits the NLRP3 inflammasome, as evidenced by a significant reduction in IL-1beta release."

25152324

---

➶

reach

"The structure activity relationship experiments (XREF_FIG) suggest that glyburide inhibits the Cryopyrin inflammasome independently of SUR1 containing K ATP channels."

19805629

---

➶

reach

"Glyburide, the most widely used sulfonylurea drug for type 2 diabetes in the US, inhibits the Nalp3 inflammasome."

22065079

---

➶

reach

"Lamkanfi et al. demonstrated that glibenclamide could inhibit the assembly of the NALP3 inflammasomes in response to stimulation with lipopolysaccharide (LPS) and adenosine triphosphate (ATP) [XREF_BIBR]."

25077824

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➶

reach

"The sulfonylurea Glyburide inhibits ATP sensitive K + (K ATP) channels and has been shown to inhibit NLRP3 inflammasome activation, without affecting the NLRP1 or NLRC4 inflammasomes."

26024799

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➶

reach

"The decrease in nerve density was blocked by glyburide or anakinra, clearly implicating the NLRP3 pathway in denervation."

28984997

---

➶

reach

"Our results indicated that glibenclamide suppressed NLRP3, caspase-1, and IL-1beta in mice spinal cord in morphine tolerance."

29178967

---

➶

reach

"This, in addition to the findings by the same group showing glyburide inhibits the inflammasome upstream of the NLRP3 subunit (likely through inhibition of K ATP channel mediated efflux of K +), provides strong evidence that glyburide is indeed specifically inhibiting NLRP3 inflammasome activation [XREF_BIBR]."

25152324

---

➶

reach

"In this study, we show that glyburide prevented activation of the Cryopyrin inflammasome by a variety of stimuli."

19805629

---

➶

reach

"Glyburide and fluoxetine inhibited NLRP3 inflammasome activation in hippocampi via downregulating TXNIP."

29084550

---

➶

reach

"Neither glyburide nor compound G1 reduced the ATPase activity of recombinant Cryopyrin (XREF_FIG; and Fig."

19805629

---

➶

reach

"Glyburide, a type 2 diabetes drug, has been shown to specifically inhibit the NLRP3 inflammasome in response to microbial and crystalline stimuli XREF_BIBR."

25254654

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➶

reach

"The effects of the caspase‐1 inhibitor ZYVAD‐fmk or NLRP3 antagonist glyburide, and treatment with S1P or the S1P receptor regulator FTY720, with or without exposure to cigarette smoke extract were investigated.In alveolar macrophages, cigarette smoke induced increased intracellular expression of IL‐1β (~15%, p<0.05 on pooled data from 3 donors), with particulate staining for cleaved IL‐1β increased both inside and outside the cell (5 fold, p<0.001 on pooled data)."

28299871

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➶

reach

"This is the first study demonstrating that experimental SAP in obese rodents can be mitigated using glyburide, which has been shown to inhibit the NLRP3 inflammasome."

25152324

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➶

reach

"In this work, we found that glibenclamide could inhibit Nalp3 inflammasomes and Caspase-1 induced by LPS+ high glucose stimulation in cultured peritoneal macrophages, suggesting that the effects of glibenclamide on prevention of serum IL-1beta and TNF-alpha might be related to inhibiting Nalp3 inflammasomes and Caspase-1."

25077824

---

➶

reach

"Glyburide (glibenclamide), a sulfonylurea drug for the treatment of type 2 diabetes, is known to inhibit ATP sensitive K+ channels and thus can prevent NLRP3 inflammasome activation."

23515136

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➶

reach

"Consistently, glibenclamide also blocked the oligomerization of ASC (XREF_FIG) and the association of NLRP3 and ASC (XREF_FIG and XREF_SUPPLEMENTARY) in mouse BMDMs in response to 25-HC treatment."

27779191

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➶

reach

"Glyburide had no effect on NLRP3, caspase-1 and IL-1beta expression as compared with the control group, while the NLRP3, caspase-1 and IL-1beta were decreased by (20.49 +/-7.6)% (t = 2.862, P < 0.01), (32.94 +/-3.44)% (t = 4.154, P < 0.001) and (24.67 +/-5.29)% (t = 2.335, P < 0.05) in the PDGF+ glyburide group, respectively, as compared with the PDGF group."

28592027

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➶

reach

"When infection experiments were performed in the presence of glyburide, a compound that inhibits NLRP3 inflammasome, or A151, a specific AIM2 inhibitor, the secretion of IL-1beta was significantly inhibited with respect to uninfected controls."

32038610

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➶

reach

"IL-1beta secretion was not affected by treatment with the NLRP3 inhibitor glyburide XREF_BIBR or parthenolide, which has also been shown to inhibit NLRP3 XREF_BIBR."

22216309

---

➶

reach

"Glyburide appears to inhibit the NLRP3 inflammasome and the subsequent IL-1activation in macrophages (178) ."

32445957

---

➶

reach

"Glibenclamide is known to block the NLRP3 (NACHT, LRR, and PYD domains containing protein 3) inflammasome, which has been implicated in the pathophysiology of EAE [XREF_BIBR]."

26581714

---

➶

reach

"The type 2 diabetes drug glyburide also prevents activation of the NLRP3 inflammasome [XREF_BIBR]."

28473983

---

➶

reach

"Collectively, these results indicate that glyburide inhibits engagement of the Cryopyrin inflammasome by diverse stimuli and that inhibition occurs downstream of the P2X 7 receptor (XREF_FIG)."

19805629

---

➶

reach

"This possibility is supported by a preliminary study, in which we found that a long-term treatment of glyburide to inhibit NLRP3 did not extend the survival of M. tuberculosis infected mice (data not shown)."

21740493

---

➶

reach

"Previous study demonstrated that glibenclamide was able to suppress NALP3 activation independently of K ATP [XREF_BIBR]."

25077824

---

➶

reach

"Glyburide (International Nonproprietary Name : glibenclamide), an antidiabetic sulfonylurea drug, inhibits NLRP3 inflammasome activation by several stimuli, without affecting the NLRC4 or NLRP1 inflammasomes [XREF_BIBR]."

25152324

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➶

reach

"For instance, glybenclamide (aka glyburide), which blocks potassium efflux and therefore NLRP3 inflammasome activation, was shown to significantly reduce colitis in Il10 -/- mice as well as the expression of cytokines such as TNF, IL-6, IL-1beta, and IL-17 in intestinal tissue explants derived from Crohn 's disease patients relative to controls [88]."

29433944

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➶

reach

"Moreover, our study provided a clinically safe and effective hypoglycemic drug, glibenclamide, which inhibited HSP70 release by blocking K ATP channel and suppressed NLRP3 inflammasome activation, which consequently attenuated morphine tolerance."

29178967

---

➶

reach

"Glyburide (glibenclamide), a sulfonylurea drug used for the treatment of type-2 diabetes, is known to inhibit ATP sensitive K + channels and can thus prevent NLRP3 inflammasome activation."

26279628

---

➶

reach

"The mechanism how glibenclamide inhibits NALP3 inflammasomes and suppresses IL-1beta secretion is an intriguing question."

25077824

---

➶

reach

"Glyburide (glibenclamide), a sulfonylurea drug used for the treatment of type-2 diabetes, is known to inhibit ATP sensitive K + channels and can thus prevent NLRP3 inflammasome activation."

26279628

Tofacitinib affects JAK1

21 | 2 2 59

Tofacitinib inhibits JAK1. 84 / 84

21 | 2 2 59

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➶

reach

"Tofacitinib is a selective inhibitor of Jak1 and Jak3 and was approved for treating moderate to severe rheumatoid arthritis."

30047338

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➶

reach

"5 Tofacitinib is a potent inhibitor of JAK1 and JAK3 but not JAK2 and has been used as monotherapy for treatment of rheumatoid arthritis."

28284718

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➶

reach

"A recent study has shown that tofacitinib inhibits both JAK1 and 3, and is capable of interfering with Th1, Th2 and Th17 differentiation and effector function [XREF_BIBR]."

21751954

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➶

reach

"Targeting JAKs is also a reality in RA, such as tofacitinib targeting JAK1, JAK2 and JAK3 to treat RA (Phase III), VX-509 and R-348 targeting JAK3 to treat RA (Phase II) XREF_BIBR."

24204584

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➶

tas

No evidence text available

23659214

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➶

reach

"Tofacitinib, an oral small molecule that inhibits JAK 1 and 3 (and JAK 2 at higher doses), has undergone phase 2 and 3 studies in UC."

27461274

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➶

reach

"47 These findings are also demonstrated by tofacitinib, which blocks JAK 1 and 3, and is the most extensively studied JAK inhibitor."

32676569

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tas

No evidence text available

19053756

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➶

reach

"More recently, it was found that tofacitinib also inhibits JAK1, which mediates interferon and IL-6-induced pro inflammatory effects."

25415616

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➶

reach

"Tofacitinib, which primarily inhibits JAK-3 and JAK-1 and, to a lesser extent, JAK-2, was shown to be effective in RA patients with inadequate responses to methotrexate (MTX) and anti-tumor necrosis factor (anti-TNF) agents as well as in MTX-naive RA patients 4, 5, 6, 7, as was baricitinib, a JAK-1/2 inhibitor 8, 9."

27390150

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➶

reach

"Never the less, the ability of tofacitinib to inhibit JAK1 signaling potentially exposes patients to viral infections."

23028408

---

➶

reach

"For example, tofacitinib (CP-690,550), which inhibits Jak1, Jak2, and Jak3, has demonstrated efficacy in Phase II trials for rheumatoid arthritis [XREF_BIBR - XREF_BIBR]."

22995073

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➶

medscan

"Interestingly, tofacitinib, a molecule that inhibits JAK3 and JAK1 and to a lesser extent JAK2, has shown robust and sustained efficacy in patients with Rheumatoid arthritis [ ]."

25815310

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➶

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"38 Notably, in spite of the (partially) distinct pharmacodynamic effects of the two compounds (ie, tofacitinib predominantly inhibiting JAK1 and JAK3, baricitinib predominantly inhibiting JAK1 and JAK2), their safety profile is very similar, suggesting that the actual in vivo effects might not be predicted entirely by in vitro " selectivity " assays."

32676568

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➶

reach

"XREF_BIBR Although in vitro studies suggested that tofacitinib inhibits JAK1, JAK2, JAK3, and to a lesser extent TYK2 in human cells, in vivo studies have demonstrated it preferentially inhibits JAK1 and JAK3 pathways."

31819376

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➶

reach

"Tofacitinib is a specific inhibitor of JAK3 and to a lesser extent JAK1 and JAK2."

32397174

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➶

tas

No evidence text available

22591402

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➶

reach

"118 The first JAK inhibitor developed for autoimmune disease treatment in humans was tofacitinib, which inhibits JAK1, JAK3 and to a lesser extent JAK2."

27350879

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➶

reach

"XREF_BIBR Consequently, the immunomodulatory mechanisms of JAK1 and JAK3 inhibition by tofacitinib are expected to block or attenuate T-cell function, T-cell differentiation and cytokine signalling (e.g. IL-6, IL-21, IL-23, IFN-gamma), which play a key role in the pathogenesis of psoriasis."

23387374

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➶

eidos

"Tofacitinib inhibits JAK1 and JAK2 to a greater degree than was initially thought and also inhibits Tyk2 marginally.139 , 140 , 141 , 142 , 143 , 144 ."

| PMC

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➶

tas

No evidence text available

21106455

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➶

reach

"Tofacitinib is a small-molecule inhibitor of JAK1, JAK3 and, to a lesser extent, JAK2, and is administered orally [XREF_BIBR]."

24566842

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➶

reach

"It was soon clear that Tofacitinib inhibits not only JAK3 (IC50, 1nM) but can also inhibit JAK1 (IC50, 112nM) as well as JAK2 (IC50, 20nM) enzymatic activity."

23743669

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➶

tas

No evidence text available

24461299

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➶

reach

"Thus the ability of tofacitinib to block JAK1 may be an important contributor to the efficacy of the drug."

23028408

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➶

reach

"Tofacitinib potently inhibits JAK1, JAK2, and JAK3 and, to a lesser extent, TYK2 in biochemical assay (IC50 = 3.2, 4.1, 1.6, and 34 nM respectively)."

32326669

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➶

tas

No evidence text available

25262541

---

➶

eidos

"Tofacitinib inhibits JAK1 and JAK2 to a greater degree than was initially thought and also inhibits Tyk2 marginally ."

| PMC

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➶

tas

No evidence text available

24398382

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➶

reach

"Tofacitinib preferentially inhibits JAK-3 and/or JAK-1, modulating the immune response via down-regulation of several cytokines (e.g., interleukins 2, 4, 7, 9, 15, and 21) that are integral to lymphocyte development and function."

24943354

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➶

reach

"XREF_BIBR Tofacitinib preferentially inhibits JAK3 and JAK1, modulating the immune response via downregulation of several cytokines (eg, interleukins (ILs) 2, 4, 7, 9, 15 and 21) that are integral to lymphocyte development and function."

26318385

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➶

tas

No evidence text available

29156136

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➶

tas

No evidence text available

23540648

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➶

reach

"Tofacitinib is an oral inhibitor of JAK1, 2, and 3 to block signaling pathways of gamma chain containing cytokines, including IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 [XREF_BIBR]."

28420941

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➶

reach

"Further, innate anti-viral defenses in humans rely upon interferon signaling via the JAK1 receptor that is inhibited by tofacitinib [XREF_BIBR]."

27113415

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➶

reach

"Tofacitinib is a potent inhibitor of JAK1 and JAK3 and currently approved for the treatment of rheumatoid arthritis (RA), has demonstrated effectiveness in the treatment of psoriasis in phase III clinical trials, and is currently tested as immunomodulator for organ transplantation [XREF_BIBR]."

26983628

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➶

reach

"Tofacitinib inhibits JAK 1 and JAK 3, and to a lesser extent also JAK 2, modulating the signaling of interleukins 2, 4, 7, 9, 15, and 21 [XREF_BIBR]."

30174394

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➶

reach

"Tofacitinib inhibits JAK1 and JAK3 signaling resulting in reduced synthesis of pro inflammatory cytokines."

26031830

---

➶

reach

"Subsequently it was clear that tofacitinib also blocks JAK1 and to a lesser degree JAK2 [XREF_BIBR]."

29862290

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➶

tas

No evidence text available

29298069

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➶

reach

"Thus, tofacitinib is a potent inhibitor of Jak3 and Jak1 with some activity against Jak2."

24131352

---

➶

reach

"Tofacitinib has a short half-life of 3 hours and specifically inhibits JAK1, JAK2, and JAK3; however, in vitro studies show preferential inhibition of JAK1 and JAK3 over JAK2."

28838419

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➶

reach

"However, clinical study data thus far available have established that the drug appears to have an acceptable safety profile, sufficient as to allow utilization and exploration across a range of immune mediated diseases, and the ability of tofacitinib to inhibit JAK1 and JAK2 may have improved tofacitinib 's efficacy in autoimmunity."

25587654

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➶

reach

"The compound that is furthest advanced in clinic trials is tofacitinib, which predominantly inhibits JAK1 and JAK3."

26938566

---

➶

reach

"Tofacitinib inhibited JAK1, JAK2, and JAK3 with nanomolar potency and Tyk2 with 10-fold weaker potency, consistent with a previous report [XREF_BIBR]."

25387665

---

➶

reach

"Tofacitinib inhibits Jak3 and Jak1 and to a lesser extent Jak2."

23532440

---

➶

reach

"This is consistent with the in vitro potency that shows that tofacitinib inhibits JAK1 and JAK3 to a similar extent."

30886973

---

➶

reach

"Tofacitinib has been shown to block Jak1, Jak3 and, to a lesser extent, Jak2 [XREF_BIBR]."

24620738

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➶

reach

"This difference may be in part attributable to the weak JAK3 potency of upadacitinib, whereas tofacitinib has been reported to potently inhibit both JAK3 and JAK1 [XREF_BIBR]."

30886973

---

➶

reach

"Additionally, tofacitinib, a small molecule targeting Janus activated kinase (JAK), was shown to particularly inhibit JAK1 and JAK3, also interfering with several cytokine receptors."

26339135

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➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

25369270

---

➶

tas

No evidence text available

14593182

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➶

reach

"XREF_BIBR Tofacitinib inhibits JAK1, JAK2, and JAK3 in vitro with functional cellular selectivity for JAK1 and JAK3 over JAK2."

25279127

---

➶

reach

"Tofacitinib is a selective inhibitor of Jak1 and Jak3 which has been approved for the treatment of moderate to severe rheumatoid arthritis [XREF_BIBR, XREF_BIBR]."

28070525

---

➶

reach

"These JAK inhibitors include tofacitinib, which inhibits primarily JAK1 and JAK3, with little impact on JAK2."

31008170

---

➶

reach

"Ghoreschi et al. [XREF_BIBR, XREF_BIBR] reported that tofacitinib potently inhibited Jak3 and Jak1 and to a lesser extent Jak2 with little effects on Tyk2 and that it, thereby, inhibited signaling by interferon gamma (IFN-gamma), IL-6 and to a lesser extent IL-12 and IL-23, indicating that Th1 cell differentiation is therefore blocked, as is the generation of pathogenic Th17 cells."

26932398

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➶

reach

"This phenomenon was also observed with tofacitinib, confirming that tofacitinib inhibits JAKs (JAK1, JAK2, and JAK3), but not TYK2."

30002661

---

➶

tas

No evidence text available

23541670

---

➶

reach

"Tofacitinib is an inhibitor of Janus kinase 1 and 3 (with much lower affinity for JAK2 and TYK) [XREF_BIBR]."

24860653

---

➶

reach

"Tofacitinib is an inhibitor of Janus kinase 1 (JAK1), the IFN-alpha receptor associated protein tyrosine kinase that is activated by the binding of IFN-alpha to its receptor."

26691497

---

➶

reach

"The kinase inhibitor Tofacitinib (Tofa), a small molecule that preferentially blocks JAK1 activity, was administered in a clinically relevant regimen to mimic the human exposure, at doses that largely block phospho-Stat1 activation by IFN, alone or prior to a 2-hr parenteral IFN challenge."

26824662

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➶

tas

No evidence text available

21105711

---

➶

tas

No evidence text available

23214979

---

➶

tas

No evidence text available

27137359

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➶

reach

"6 Because tofacitinib blocks Jak1 and Jak2, it interferes with the differentiation of IFN-gamma producing Th1 cells."

23532440

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➶

reach

"XREF_BIBR In contrast, currently marketed JAK inhibitors have greater selectivity for certain JAK isoforms : tofacitinib inhibits JAK1, JAK2, JAK3 and to a lesser extent TYK2, XREF_BIBR while baricitinib has greater potency against JAK1 and JAK2 than against JAK3 and TYK2."

31350270

---

➶

tas

No evidence text available

26059596

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➶

reach

"This is in part due to that fact that tofacitinib inhibits JAK1 and JAK3, but decernotinib selectively inhibits JAK3."

28790974

---

➶

reach

"Tofacitinib is the first inhibitor of the JAK1 and JAK3 signalling pathways that has demonstrated efficacy in controlling disease in RA [XREF_BIBR]."

29556907

---

➶

reach

"Tofacitinib inhibits JAK1 and JAK2 to a greater degree than was initially thought and also inhibits Tyk2 marginally.139, 140, 141, 142, 143, 144Tofacitinib is the most potent (inhibitory potency of 1 nM) and selective JAK3 inhibitor developed to date."

| PMC

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➶

reach

"5 Tofacitinib interferes with the JAK-STAT signaling by competing with ATP for binding to the kinase domain of JAKs and inhibits JAK1, JAK2, and JAK3."

25110261

---

➶

tas

No evidence text available

26927423

---

➶

tas

No evidence text available

22037378

---

➶

reach

"Tofacitinib inhibits JAK3 and JAK1 signaling for multiple cytokines important in psoriasis, including IL-6 and IL-17."

27471688

---

➶

reach

"Tofacitinib inhibits JAK1 and JAK2 to a greater degree than was initially thought and also inhibits Tyk2 marginally."

| PMC

---

➶

tas

No evidence text available

24417533

---

➶

reach

"Tofacitinib preferentially inhibits JAK 3, JAK 1 and, to a lesser extent, JAK 2, in a reversible manner."

32655703

---

➶

reach

"Tofacitinib potently inhibits JAK3 and JAK1 and to a lesser extent JAK2 and shows a high degree of kinome selectivity."

29946544

---

➶

reach

"Interestingly, tofacitinib, a molecule that inhibits JAK3 and JAK1 and to a lesser extent JAK2, has shown robust and sustained efficacy in patients with RA [XREF_BIBR]."

25815310

---

➶

medscan

"Jakafi (ruxolitinib) inhibits JAK1 and JAK2 whereas Xeljanz (tofacitinib) inhibits JAK3 and to a lesser extent JAK1."

26981780

---

➶

reach

"Thus, tofacitinib that inhibits JAK1, JAK2, JAK3 and, to a lesser extent, TYK2 is used in the clinic for treating RA patients in many countries."

28456914

---

➶

reach

"Tofacitinib inhibits Jak3 and Jak1, while Ruxolitinib blocks Jak2 and Jak1."

30061883

---

➶

reach

"Tofacitinib is a potent inhibitor of JAK1 and JAK3."

28209624

Reactive oxygen species affects NLRP3

| 66

Reactive oxygen species inhibits NLRP3. 66 / 66

| 66

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➶

reach

"We propose that cytosolic ROS and RNS inhibit the NLRP3 inflammasome and that PCN 's anti-inflammatory activity may help P. aeruginosa evade immune recognition."

29414783

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➶

reach

"ROS scavenger dissociates TXNIP from NLRP3, and inhibits NLRP3 inflammasome activation in cardiac microvascular endothelial of C57BL/6J mice with simulated ischemia and reperfusion injury XREF_BIBR."

27270216

---

➶

reach

"TRIM30 knockdown increases ROS production, which enhances NLRP3 inflammasome activation."

25324778

---

➶

reach

"A recent study showed that ROS inhibitor such as DPI abolished IL-1beta release in mouse macrophages by inhibiting NLRP3 gene expression XREF_BIBR."

24223129

---

➶

reach

"Interruption of ROS production with pharmacological inhibitors blocks activation of the Nlrp3 inflammasome, suggesting that the generation of ROS is a required upstream event for Nlrp3 activation."

23954133

---

➶

reach

"Conversely, a ROS scavenger that dissociates Txnip from NLRP3 inhibits the activation of NLRP3 inflammasome in microvascular endothelial cells."

27807222

---

➶

reach

"Finally, RSV and Japanese encephalitis virus (JEV) have both been found to induce NLRP3 activation through K + efflux from the cell and ROS production as treatment with K + buffered medium or the ROS inhibitors APDC or diphenyleneiodonium chloride (DPI) inhibited NLRP3 inflammasome activation."

23947344

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➶

reach

"Here we demonstrate that a known potent inducer of ROS can also inhibit NLRP3 inflammasome activation."

24337744

---

➶

reach

"Unexpectedly, knockdown of NCLX induced ROS generation and increased activation of the NLRP3 inflammasome."

26089852

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➶

reach

"In a word, these findings demonstrate that AS pretreatment attenuated RIR mediated ALI potentially through reducing ROS induced activation of the NLRP3 inflammasome."

29730819

---

➶

reach

"Nlrp3 activation is blocked by ROS scavengers and NAPDH oxidase inhibitors 65."

22430785

---

➶

reach

"Previous studies demonstrated that reactive oxygen species (ROS) was a necessary step for NLRP3 activation, and inhibition ROS production by ROS inhibitor suppressed NLRP3 inflammasome activation."

29163015

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➶

reach

"The administration of a non specific ROS scavenger, PBN, markedly alleviated mechanical allodynia and inhibited the activation of NLRP3 inflammasome in DRGs and sciatic nerve of the paclitaxel induced neuropathic pain model."

28714351

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➶

reach

"NLRP3 inflammasome activation by decreased ROS through mitophagy might play a crucial role in berberine (BBR)-mediated alleviation of IV induced inflammatory lesions [XREF_BIBR]."

| PMC

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➶

reach

"While scavenging of ROS by NAC also attenuated liver inflammation, NLRP3 inflammasome activation and IL-1beta production, indicating an important role of ROS in mediating NLRP3 inflammasome activation in experimental AIH."

29692782

---

➶

reach

"Recently, it has been reported that ROS derived iNOS inhibits NLRP3 inflammasome activity."

30214444

---

➶

reach

"Specifically, the antioxidant properties of polyphenols outlined in Section Polyphenol Compounds as Free Radical Scavengers identify them as potential inhibitors of ROS mediated NLRP3 activation."

30210334

---

➶

reach

"Moreover, ROS was required for E. coli O157 : H7 induced NLRP3 assembly as inhibiting mitochondrial ROS release by ROS scavengers Mito-TEMPO and N-acetylcysteine abrogated NLRP3 inflammasome activation in Caco-2 cells in response to E. coli O157 : H7."

28476502

---

➶

reach

"ROS scavenger dissociated TXNIP from NLRP3 and inhibited the activation of NLRP3 inflammasome in the CMECs."

25015733

---

➶

reach

"Inhibition of autophagy induces IL-1beta release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress."

26102024

---

➶

reach

"ROS have been shown to activate the inflammasome in MI/R injury [XREF_BIBR, XREF_BIBR], ROS generation has been identified as an important mechanism by which NLRP3 inflammasome is activated, and NLRP3 activation was blocked by ROS scavengers [XREF_BIBR]."

29062465

---

➶

reach

"Inhibition of mitochondrial complex I-induced- ROS impairs NLRP3 inflammasome activity [46], and impaired monocyte NLRP3 activity is associated with mitochondrial dysfunction and increased risk of death in sepsis [47]."

31996961

---

➶

reach

"Moreover, a specific mitochondria ROS scavenger, the mito-TEMPO (500 muM), abrogated mtROS release, inhibited NLRP3 inflammasome activation and reduced the up-regulation of IL-1beta and IL-18 induced by ethanol or lipopolysaccharide (LPS)/ATP."

30873011

---

➶

reach

"Oxidative stress is considered an important driver of NLRP3 inflammasome activation, and ROS scavenging can attenuate NLRP3 inflammasome activation [XREF_BIBR]."

32064027

---

➶

reach

"Furthermore, our data indicated that a ROS scavenger can significantly prevent Nlrp3 inflammasome activation and cytokine release during albumin stimulation, indicating that redox signalling drives Nlrp3 activation."

25281528

---

➶

reach

"However, recent findings that elimination of ROS by antioxidants suppressed activation of NLRP3 inflammasome and the resultant maturation of IL-1beta have shed new light on understanding the roles of antioxidants in pathogenesis of inflammation related diseases [XREF_BIBR]."

25214720

---

➶

reach

"More importantly, ROS specific inhibitor NAC prevented fructose induced alteration of NLRP3 and IL-1beta, as well as TGF-beta, p-Smad2/3 and Smad4 in H9c2 cells (XREF_FIG)."

27270216

---

➶

reach

"In addition, downregulated serum IL-1beta and IL-18, as well as dampened activity of caspase-1 in liver homogenates of NAC pretreated mice indicated that scavenging ROS actually inhibited NLRP3 inflammasome activation."

29692782

---

➶

reach

"While many activators of the NLRP3 inflammasome generate ROS, the interruption of ROS production with pharmacological inhibitors can block the activation of NLRP3."

30873162

---

➶

reach

"Moreover, the scavenging ROS relieved the autophagy, NLRP3 inflammasome activation and pyroptosis."

30205151

---

➶

reach

"Interruption of ROS production by pharmacological inhibitors or scavengers inhibit NLRP3 inflammasome activation in response to many, if not all, previously evaluated activators, suggesting that ROS generation is a common upstream event required for NLRP3 activation."

26081624

---

➶

reach

"We also observed the inhibition of ROS mediated NLRP3 activation, as well as the decrease of NF-kappaB p65 nuclear translocation and its downstream inflammatory cascades."

30805082

---

➶

reach

"In addition, it still remains a mystery as to what molecule (s) are targeted by ROS to enhance NLRP3 inflammasome activation."

21884179

---

➶

reach

"Pathophysiological changes mediated by mitochondria including the imbalance in mitochondrial dynamics and the release of cytochrome c, mitochondrial DNA or reactive oxygen species (ROS) can either activate or inhibit the NLRP3 inflammasome [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."

30096906

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➶

reach

"Scavenging of ROS by N-acetyl-cysteine also attenuated NLRP3 inflammasome activation and liver inflammation, indicating that the essential role of ROS in mediating NLRP3 inflammasome activation in ConA induced hepatitis."

29692782

---

➶

reach

"Some investigators have suggested that signaling by ROS drives NLRP-3 inflammasome formation, while others reported that an inducer of ROS can inhibit NLRP-3 inflammasome activation."

29067455

---

➶

reach

"Furthermore, experiments indicated that MSNs induced mitochondrial reactive oxygen species (ROS) generation, and the ROS scavenger could attenuate the MSN activated NLRP3 inflammasomes and pyroptosis in the liver."

29722780

---

➶

reach

"Blockade of MR with EPL significantly prevented mitochondrial ROS production and activation of the NLRP3 inflammasome."

27014913

---

➶

reach

"Autophagy Inhibition Contributes to ROS Producing NLRP3 Dependent Inflammasome Activation and Cytokine Secretion in High Glucose Induced Macrophages."

28854426

---

➶

reach

"Methods : Vascular reactivity, reactive oxygen species (ROS) generation, calcium (Ca 2+) influx and caspase-1 and IL-1beta activation were determined in mesenteric resistance arteries from normoglicemic and streptozotocin induced diabetic C57BL/6 and NLRP3 knockout (Nlrp3 -/-) mice."

32009974

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➶

reach

"Intriguingly, the ROS induced NLRP3 inflammasome up-regulation was suppressed by NF-kB inhibitor, which indicated NF-kB was an essential link between ROS and NLRP3 inflammasome."

25136835

---

➶

reach

"Therefore, ROS induced NLRP3 inflammasome activation is potentially a novel target for the prevention and treatment of CMV associated SNHL."

29512778

---

➶

reach

"Additionally, mitochondrial ROS (mtROS) scavenger mito-TEMPO abolished NLRP3 inflammasome activation in IH treated RAW264.7 cells."

32066884

---

➶

reach

"Some debate exists on what type of ROS is important for NLRP3 activation as ROS scavengers and inhibitors strongly impede NLRP3 activation."

24829412

---

➶

reach

"These data are relevant because it has been reported that ROS induced TXNIP-NLRP3 association, and TXNIP deficiency inhibited ROS mediated NLRP3 inflammasome activation 18."

23838164

---

➶

reach

"Furthermore, BHB decreased reactive oxygen species (ROS) generation, inhibited ROS-NLRP3 pathway in OGD/R treated cells, and suppressed ER stress induced NLRP3 inflammasome activation."

29662437

---

➶

reach

"Recent findings that elimination of ROS by antioxidants suppressed activation of the NLRP3 inflammasome and the resultant maturation of IL-1beta have shed new light on understanding the roles of antioxidants in the pathogenesis of inflammation related diseases XREF_BIBR."

27917949

---

➶

reach

"In conclusion, H 2 S ameliorates the toxic effects of PQ on the liver by enhancing antioxidative capability, regulating mitochondrial function, and suppressing ROS induced NLRP3 inflammasome activation."

32064027

---

➶

reach

"We reported previously that high glucose and lipopolysaccharide activate ROS-TXNIP-NLRP3 inflammasome signaling in GMCs, but ROS inhibitor N-acetylcysteine (NAC) could not completely inhibit the activation of NLRP3 inflammasome induced by high glucose, suggesting that there may be other pathways by which high glucose primes ROS-NLRP3 inflammasome signaling [XREF_BIBR]."

29675433

---

➶

reach

"ROS act as signaling molecules and regulate metabolism, proliferation XREF_BIBR and inflammation, as indicated by the fact that either deficiency in NADPH oxidase (an enzymatic ROS source) or the presence of antioxidants inhibit NLRP3 inflammasome activation XREF_BIBR."

28084303

---

➶

reach

"Interruption of ROS production using inhibitors blocks NLRP3 activation, suggesting ROS production upstream is necessary for NLRP3 activation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

29120406

---

➶

reach

"The lysosomal NADPH oxidase appeared to be a good candidate for the source of ROS and silencing NADPH oxidase reduced NLRP3 activation by asbestos and MSU."

25879282

---

➶

reach

"Researchers demonstrated that Nrf2 inhibition of ROS induced NLRP3 priming required the participation of NAD (P) H quinone dehydrogenase 1 (NQO1) [XREF_BIBR]."

32655760

---

➶

reach

"ROS induced NLRP3 activation was diminished by the knocking-down of voltage dependent anion channel-1, which is tightly regulated by Bcl-2."

25879294

---

➶

reach

"Inhibition of mitochondrial complex I by rotenone or complex III by antimycin A induces robust mitochondrial ROS production, which drives NLRP3 inflammasome activation."

28729463

---

➶

reach

"Our recent results showed that ROS scavenging by anti-oxidants such as NAC or mito-TEMPO inhibits priming and activation of NLRP3, whereas induction of mitochondrial ROS (mtROS) by rotenone can lead to its potent priming and activation."

24048902

---

➶

reach

"Moreover, intracellular ROS and RNS were sufficient to inhibit activation of NLRP3."

29414783

---

➶

reach

"The use of ROS scavenger N-acetylcysteine (NAC) partially reversed NLRP3 inflammasome activity in cells exposed to burn serum."

26576075

---

➶

reach

"PCN induced intracellular ROS and RNS inhibited the NLRP3 inflammasome posttranslationally, and hydrogen peroxide or peroxynitrite alone were sufficient to block its activation."

29414783

---

➶

reach

"Further experiments demonstrated that the QDs induced mitochondrial reactive oxygen species (mtROS) production, and that both a mtROS and a total ROS scavenger attenuated QDs induced NLRP3 activation and pyroptosis."

26986854

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➶

reach

"Inhibition of NADPH oxidase dependent ROS production has been previously suggested to occur upstream of NLRP3 inflammasome activation, and accumulation of ROS producing mitochondria by rotenone, a pharmacological inhibitor of the mitochondrial electron transport chain, was recently shown to trigger NLRP3 inflammasome activation [22]."

25461402

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➶

reach

"Scavenging of ROS blocks NLRP3 inflammasome activation in response to a wide variety of stimuli."

25356867

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➶

reach

"NLRP3 activation can be blocked by ROS scavengers XREF_BIBR."

25136835

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➶

reach

"Disruption of glycolytic flux led to an NAD +/NADH imbalance and induced mitochondrial ROS accumulation, which has been shown here and elsewhere to activate the NLRP3 inflammasome (XREF_FIG)."

27011353

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➶

reach

"Similarly, inhibitors of ROS production or scavengers of ROS, including NAD (P) H oxidase inhibitors can suppress NLRP3 activation."

25338942

---

➶

reach

"Several NLRP3 activators such as ATP, silica and asbestos trigger ROS generation and its suppression using ROS scavengers blocks NLRP3 activation."

25324778

Ruxolitinib affects JAK1

1 13 | 2 47

Ruxolitinib inhibits JAK1. 60 / 60

1 13 | 2 44

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➶

reach

"Ruxolitinib, a kinase inhibitor, down-regulates overactive signaling of JAK1 and JAK2, which are responsible for mediating signals of cytokines and growth factors necessary for hematopoiesis and immune function (see XREF_FIG)."

29226001

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➶

reach

"Ruxolitinib inhibits JAK1 and JAK2 and clinically improves the symptoms associated with MPNs."

28789350

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➶

tas

No evidence text available

24461299

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➶

reach

"In kinase assays INCB018424 inhibited JAK1 and JAK2 at similar potencies (half-maximal inhibitory concentrations [IC50] 3.3 nM and 2.8 nM, respectively), while being selective against TYK2 and JAK3 (XREF_TABLE)."

22035745

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➶

reach

"In vitro enzyme assays confirm that ruxolitinib inhibits JAK1 and JAK2 with IC 50 values of 3.3 nM and 2.8 nM, respectively; IC 50 values are approximately 6-fold greater for TYK2 and> = 130-fold greater for JAK3 [XREF_BIBR]."

22830345

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➶

reach

"Ruxolitinib is a potent inhibitor of JAK1 and JAK2, both of which play a role in signaling proinflammatory cytokines [XREF_BIBR, XREF_BIBR]."

25980454

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➶

reach

"38 Because ruxolitinib and baracitinib inhibit Jak1 and Jak2, they block many of the same cytokines as tofacitinib."

23532440

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➶

tas

No evidence text available

23540648

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➶

reach

"Indeed, agents targeting these molecules are already approved for other indications, for example, imatinib, sunitinib, regorafenib, and other kinase inhibitors inhibit KIT and ruxolitinib inhibits JAK1."

28753783

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➶

reach

"Ruxolitinib has been reported to inhibit JAK1 and JAK2 with nanomolar potency and JAK3 with 100-fold weaker potency [XREF_BIBR]."

25387665

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➶

tas

No evidence text available

22698084

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➶

reach

"By inhibiting JAK1 and JAK2, ruxolitinib modulates cytokine stimulated intracellular signaling."

22399854

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➶

reach

"Ruxolitinib (Incyte) selectively inhibits JAK1 and JAK2, and was initially shown to be effective in the treatment of myelofibrosis."

25110261

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➶

reach

"Ruxolitinib is a selective inhibitor of JAK1 and JAK2 that is licensed to treat myelofibrosis [XREF_BIBR] and being evaluated in CLL [XREF_BIBR]."

27579615

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➶

reach

"Ruxolitinib and TPCA-1 were able to inhibit JAK1 kinase activity in a dose dependent manner with an IC 50 of 4.33 nM and 43.78 nM, respectively, while BMS-345541 did not affect the kinase enzymatic activity."

26331681

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➶

reach

"Nowadays, the only JAK inhibitor approved for the treatment of primary and secondary myelofibrosis is ruxolitinib, which inhibits not only JAK2 but also JAK1."

26525644

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➶

reach

"Tofacitinib inhibits Jak3 and Jak1, while Ruxolitinib blocks Jak2 and Jak1."

30061883

---

➶

tas

No evidence text available

27137359

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➶

reach

"INCB018424 inactivates both JAK1 and JAK2 in DLD-1 cells but inactivates only JAK1 in RKO cells."

24050550

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➶

signor

No evidence text available

Other

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➶

reach

"Ruxolitinib is an inhibitor of Janus kinase 1 and 2 (JAK1 and 2) approved for the treatment of primary myelofibrosis and other chronic myeloid neoplasms [XREF_BIBR, XREF_BIBR] by the FDA and EMA."

30795628

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➶

reach

"Ruxolitinib, which inhibits Jak1 and Jak2, has been beneficial in a highly active RA patient group in a double-blind, placebo controlled Phase IIa trial with superior results in higher doses up to 50 mg twice daily."

22819198

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➶

reach

"Ruxolitinib, which inhibits JAK2 but also TYK2, JAK1 and JAK3 XREF_BIBR at similar degrees demonstrated durable reduction in splenomegaly and constitutional symptoms with improved quality of life in comparison to placebo controlled XREF_BIBR or best available therapy XREF_BIBR in phase 3 trials and an impact on survival for patients originally randomized to ruxolitinib compared with those originally randomized to placebo in both COMFORT trials XREF_BIBR."

26176817

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➶

tas

No evidence text available

| DOI

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➶

reach

"Similarly, Ruxolitinib inhibits the influenza prey protein JAK1, a part of the Pathways in cancer gene-set.implications both in terms of improving baseline lung function and reducing the risk of adverse consequences after SARS-CoV2 exposure.Schematic representation of drug repositioning and precision implementation in lung function deficits directed by causal enrichment of environmental and genetic risk factors."

| DOI

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➶

tas

No evidence text available

23061660

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➶

reach

"In contrast to the selective ability of TG101348 to inhibit JAK2, however, ruxolitinib inhibits both JAK1 and JAK2 equally well."

27923824

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➶

reach

"JAK1 and JAK2 inhibitor such as ruxolitinib is being used to treat MPNs and other JAK2 inhibitors are in various stages of development [XREF_BIBR]."

28977839

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➶

reach

"Jakafi (ruxolitinib) inhibits JAK1 and JAK2, whereas Xeljanz (tofacitinib) inhibits JAK3 and to a lesser extent JAK1."

27379204

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➶

tas

No evidence text available

29298069

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➶

reach

"Ruxolitinib is a selective inhibitor of JAK-1 and JAK-2 used to treat PMF."

32004164

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➶

tas

No evidence text available

26927423

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➶

reach

"Moreover, ruxolitinib, which preferentially blocks JAK1 and JAK2, abolished the proliferation of cells transformed by the receptor dependent JAK3 (V674A), yet proved much less potent on cells expressing JAK3 (L857P)."

26446793

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➶

reach

"Only ruxolitinib (selective inhibitor of JAK1 and JAK2) has received Food and Drug Administration (FDA) approval for the treatment of myelofibrosis, while many other compounds have been discontinued due to toxicity [XREF_BIBR, XREF_BIBR]."

25656053

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➶

tas

No evidence text available

22037378

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➶

reach

"Ruxolitinib is an equipotent inhibitor of JAK1 and JAK2, with in vitro IC 50 values (mean +/- standard deviation) of 3.3 +/- 1.2 nM and 2.8 +/- 1.2 nM, respectively, and with sixfold and greater than 100-fold selectivity against Tyk3 and JAK3, respectively [XREF_BIBR]."

25757677

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➶

reach

"For example, INCB018424 inhibits predominantly JAK1, whereas CEP-701 and TG101348 inhibit FLT3 in addition to JAK2."

22018018

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➶

tas

No evidence text available

21106455

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➶

reach

"However, ruxolitinib inhibits Jak1, which has been shown to be activated in astrocytes following cerebral ischemia in rats."

26851503

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➶

reach

"By directly targeting both JAK1 and JAK2 through small-molecule inhibition, ruxolitinib elicits a reduction in splenomegaly and disease related symptoms in patients with intermediate- or high-risk myelofibrosis while maintaining an acceptable toxicity profile and a low treatment discontinuation rate."

24589536

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➶

reach

"Ruxolitinib, which selectively inhibits JAK1 and JAK2 enzymes, was the first JAK inhibitor to be approved for treatment of myelofibrosis in 2011 by US-FDA."

27119045

---

➶

medscan

"SB505124 [2 μm] together with ruxolitinib [100 nM] suppresses Phosphorylated JAK1, but does not induce PARP cleavage."

26586478

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➶

tas

No evidence text available

25369270

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➶

reach

"Most experience has been in patients with myelofibrosis in phase I/II trials employing INCB018424 (a potent and selective inhibitor of JAK1 and JAK2), TG101348 (a structure based drug designed to inhibit JAK2 with great selectivity), CEP-701 (a multikinase inhibitor), and XL019 (a selective JAK2 inhibitor whose clinical development has been halted because of neurotoxicity)."

20948870

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➶

reach

"JAK1 and JAK2 inhibition by ruxolitinib improved both overall survival (P = 0.03) and acute GVHD pathologic score at target organs (P < = 0.001) of treated mice."

25977345

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➶

reach

"The promising perspective might be the use of Ruxolitinib in both BP and DH, as Ruxolitinib inhibits JAK1 and JAK2 pathways through blocking STAT3 phosphorylation, resulting in the suppression of Th17 cell differentiation, essential in both DH and BP pathogenesis [XREF_BIBR]."

29203970

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➶

reach

"AG490 is known to inhibit both JAK2 and JAK3 but not JAK1, whereas ruxolitinib may suppress both JAK1 and JAK2 while sparing JAK3 [53]."

25986861

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➶

reach

"19 Like ruxolitinib, baracitinib (formerly designated INCB028050) is also a Jak1 and Jak2 inhibitor which showed efficacy in a highly active RA patient group resistant to disease modifying drugs and biologics with superior results in higher doses up to 4 or 8 mg once daily within 2 weeks with dose dependent side effects to include decrease of hemoglobin and neutrophil count and increase of LDL and creatinine with good overall tolerability."

23532440

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➶

reach

"Ruxolitinib effectively blocks the downstream signaling effects of JAK1 and JAK2 activity."

25980454

---

➶

reach

"This led to the development of the drug, ruxolitinib, which blocks JAK1 and JAK2."

22403586

---

➶

reach

"The use of JAK1 and JAK2 inhibitors such as ruxolitinib and baricitinib for GvHD prophylaxis may limit the need for expensive and labor-intensive ex vivo cellular manipulations 38 and may also reduce the use of broadly immunosuppressive agents that may themselves contribute to disease relapse, morbidity, and mortality after allo-HSCT."

29691471

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➶

reach

"Ruxolitinib is a selective inhibitor of Janus kinase 1 and 2, which is approved to treat intermediate or high-risk myelofibrosis."

23677817

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➶

reach

"Of these compounds they found that ruxolitinib and gogicide A (which are inhibitors of JAK1 and the Golgi specific brefeldin A resistant guanine nucleotide exchange factor GBF1, respectively) markedly decreased virus titers in human cells infected with influenza virus without affecting cell viability."

26364134

---

➶

reach

"Ruxolitinib (Incyte Corporation, Wilmington, DE), also known as INCB018424, is a potent inhibitor of JAK1 and JAK2."

22815644

---

➶

medscan

"Jakafi (ruxolitinib) inhibits JAK1 and JAK2 whereas Xeljanz (tofacitinib) inhibits JAK3 and to a lesser extent JAK1."

26981780

---

➶

tas

No evidence text available

24417533

---

➶

reach

"Jakafi (ruxolitinib) inhibits JAK1 and JAK2 whereas Xeljanz (tofacitinib) inhibits JAK3 and to a lesser extent JAK1."

26981780

---

➶

reach

"Ruxolitinib also inhibits JAK1."

23391678

---

➶

reach

"In pre-clinical evaluation it was demonstrated that ruxolitinib inhibited both JAK1 (half-maximal concentration [IC50] = 3.3 nM) and JAK2 (IC50 = 2.8 nM), while sparing JAK3 (IC50 = 322nM)."

23009939

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➶

tas

No evidence text available

22591402

Ruxolitinib inhibits mutated JAK1. 2 / 2

| 2

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➶

reach

"As expected, Ruxolitinib was also efficient to inhibit JAK1 mutants, with an efficacy of = ~ 90% at 1 muM in three different hepatocellular cell lines (unpublished results)."

26188635

---

➶

reach

"To detect the sensitivity of JAK1 mutations to inhibitor, we examined whether ruxolitinib as an inhibitor for JAK1/2 could inhibit the activation of JAK1 mutants."

28410228

Ruxolitinib inhibits JAK1-T901A. 1 / 1

| 1

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➶

reach

"Ruxolitinib blocked IL7R downstream signaling in both IL7R RFCPH and JAK1 T901A lines, but was ineffective in blocking signaling in AKT or NRAS lines, as expected (Figs XREF_FIG and XREF_SUPPLEMENTARY)."

27997540

Nitric oxide affects NLRP3

| 58

Nitric oxide inhibits NLRP3. 58 / 58

| 58

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➶

reach

"NLRP3 is also negatively regulated by NO mediated S nitrosylation."

26620909

---

➶

reach

"These observations establish a mechanism whereby IFN-gamma-induced NO inhibits NLRP3 dependent IL-1 responses."

23160153

---

➶

reach

"Overall, these results suggest that excessive NO produced by Txnip -/- cells could inhibit NLRP3 inflammasome activation."

24098117

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➶

reach

"In addition, T cell derived IFNgamma has been shown to downregulate the activity of NLRP3 via activation of inducible nitric oxide synthase (iNOS) in a mouse model of tuberculosis 71; nitric oxide (NO) induces NLRP3 nitrosylation and thereby inhibits NLRP3 activity."

23702978

---

➶

reach

"We found that NO negatively regulated the activation of the NLRP3 inflammasome by stabilizing mitochondria in macrophages and prevented LPS induced septic shock in vivo."

23318584

---

➶

reach

"For instance, NO impairs the activity of the NLRP3 inflammasome, a process that is crucial for the control of tissue damage in mice models for Mycobacterium infection and septic shock [79,97]."

26440786

---

➶

reach

"In addition, we also observed increased NO production in Txnip -/- cells, which suppressed NLRP3 inflammasome activation, indicating a critical role for TXNIP in the activation of the NLRP3 inflammasome during endotoxic shock."

24098117

---

➶

reach

"Additionally, nitric oxide (NO) downregulates NLRP3 activation through enhancing the removal of the dysfunctional mitochondria and preventing assembly of the inflammasome [XREF_BIBR, XREF_BIBR]."

27652274

---

➶

reach

"Cutting edge : nitric oxide inhibits the NLRP3 inflammasome."

23100513

---

➶

reach

"The dramatic enhancement of both NO and the expression of iNOS in Txnip -/- macrophages suggested that TXNIP may be involved in NO mediated NLRP3 inhibition."

24098117

---

➶

reach

"Additionally, nitric oxide (NO) downregulates NLRP3 activation through enhancing the removal of the dysfunctional mitochondria and preventing assembly of the inflammasome [XREF_BIBR, XREF_BIBR]."

27652274

---

➶

reach

"Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS induced septic shock."

23318584

---

➶

reach

"Interestingly, another small molecule, nitric oxide (NO), attenuates NLRP3 inflammasome activity at the post-translational level by direct S-nitrosylation158.In addition to post-translational and post-transcriptional regulation, a number of molecules can directly or indirectly interact with different components of the NLRP3 inflammasome, through which they impede the assembly of NLRP3 with ASC and caspase-1."

32550001

---

➶

reach

"NO inhibits NLRP3 dependent IL-1 responses."

30915076

---

➶

reach

"In addition, T cell derived IFNgamma has been shown to downregulate the activity of NLRP3 via activation of inducible nitric oxide synthase (iNOS) in a mouse model of tuberculosis 71; nitric oxide (NO) induces NLRP3 nitrosylation and thereby inhibits NLRP3 activity."

23702978

---

➶

reach

"Nitric oxide (NO) has been reported to negatively regulate NLRP3 inflammasome mediated caspase-1 activation [XREF_BIBR]."

26491223

---

➶

reach

"Contrastingly, nitric oxide suppresses NLRP3 inflammasome dependent processing of IL-1beta and controls the immunopathology of tuberculosis infection [XREF_BIBR]."

27366746

---

➶

reach

"Similarly, the addition of NO donor compounds to macrophages or induction of NO by IFN-gamma treatment inhibited NLRP3 activation."

24062750

---

➶

reach

"Interestingly, another small molecule, nitric oxide (NO), attenuates NLRP3 inflammasome activity at the post-translational level by direct S-nitrosylation158.In addition to post-translational and post-transcriptional regulation, a number of molecules can directly or indirectly interact with different components of the NLRP3 inflammasome, through which they impede the assembly of NLRP3 with ASC and caspase-1."

32550001

---

➶

reach

"However, little is known about the regulatory mechanism for NO mediated NLRP3 inflammasome inhibition and the potential role for TXNIP in this progression."

24098117

---

➶

reach

"Nitric oxide (NO) negatively regulates NLRP3 inflammasome activation through S nitrosylation of NLRP3."

29868015

---

➶

reach

"The findings suggest that intravenous Arg supplementation immediately after sepsis restores plasma Arg levels and is beneficial for attenuating septic AKI, partly via NO mediated NLRP3 inflammasome inhibition."

32454788

---

➶

reach

"Furthermore, NO suppresses NLRP3 inflammasome activation, which is a multi protein complex that triggers the maturation of the pro inflammatory cytokines IL-1beta and IL-18."

28603491

---

➶

reach

"Also, NO inhibits the NLRP3 inflammasome activation in macrophages, which may involve S nitrosylation of NLRP3 and caspase-1 77."

31700106

---

➶

reach

"Also study by Mao et al. demonstrated that NO prevented the activation of the NLRP3 inflammasome."

28791024

---

➶

reach

"It has been demonstrated that NO negatively regulated the activation of the NLRP3 inflammasome by stabilizing mitochondria in macrophages and prevented lipopolysaccharide induced septic shock [XREF_BIBR]."

26334271

---

➶

reach

"It is interesting to note that NO mediated thiol nitrosylation inhibited assembly and activation of the NLRP3 but not AIM2 inflammasome."

29230217

---

➶

reach

"IL-1beta levels are regulated by IFN-gamma-induced nitric oxide inhibition of the NLRP3 inflammasome [XREF_BIBR]."

23790398

---

➶

reach

"In this study, we find that NO donor not only inhibits NLRP3 inflammasome activation in mouse macrophages, but also suppresses human NLRP3 inflammasome activation in human THP-1 cells and primary PBMCs."

23318584

---

➶

reach

"Recent studies suggest that nitric oxide (NO), Ca 2+ and cyclic AMP negatively regulate the NLRP3 inflammasome but the detailed mechanisms are unclear XREF_BIBR, XREF_BIBR."

27439607

---

➶

reach

"Furthermore, our in vivo results support the hypothesis that excessive NO induced by LPS treatment in Txnip -/- mice inhibited NLRP3 inflammasome activation and then prevented the secretion of IL-1beta."

24098117

---

➶

reach

"Interestingly, another small molecule, nitric oxide (NO), attenuates NLRP3 inflammasome activity at the post-translational level by direct Snitrosylation 158 ."

32550001

---

➶

reach

"Both IFN-gamma-induced NO production and NO donor (SNAP) treatment inhibit canonical and Mycobacterium tuberculosis mediated NLRP3 inflammasome activation through induction of NO induced S nitrosylation of NLRP3."

29868015

---

➶

reach

"Using an iNOS inhibitor, iNOS specific siRNA and iNOS deficient macrophages, we found that the endogenous NO derived from iNOS negatively regulates NLRP3 inflammasome activation at the late stage of LPS priming."

23318584

---

➶

reach

"Firstly, the ability of IFN-gamma or NO to specifically inhibit the NLRP3 inflammasome and not other caspase-1 containing complexes indicates that caspase-1 is unlikely to be a functional nitrosylation target in this context."

23160153

---

➶

reach

"Our observation that the human NLRP3 inflammasome is inhibited by NO further suggests a potential therapeutic application of NO in the treatment of inflammatory diseases."

23318584

---

➶

reach

"NO inhibits the assembly of the NLRP3 inflammasome."

23160153

---

➶

reach

"The addition of an NO donor (SNAP) inhibited the NLRP3 dependent maturation of IL-1beta in these transfected cells, but had no effect on the AIM2 inflammasome, implying that this compound might directly modulate the assembly or activity of the NLRP3 inflammasome (XREF_FIG)."

23160153

---

➶

reach

"While Mishra et al. report NO induced nitrosylation of NLRP3 blocks activation by preventing assembly of the inflammasome, the study by Mao et al. suggests that NO downregulates NLRP3 activation through enhancing the removal of the dysfunctional mitochondria that activate NLRP3."

24840700

---

➶

reach

"Since Arg plus L-NIL administration also attenuated kidney injury after CLP, the favorable effect of Arg resulting from NO mediated NLRP3 inflammasome inhibition may be partly responsible for attenuating septic AKI."

32454788

---

➶

reach

"Yet, NO has been previously shown to inhibit NLRP3 inflammasome activation through the S nitrosylation of NLRP3 and caspase-1 XREF_BIBR, XREF_BIBR."

28463821

---

➶

reach

"Interestingly, another small molecule, nitric oxide (NO), attenuates NLRP3 inflammasome activity at the post-translational level by direct Snitrosylation 158 ."

32550001

---

➶

reach

"These results collectively confirm that the endogenous NO produced by iNOS negatively regulates NLRP3 inflammasome activation in macrophages."

23318584

---

➶

reach

"In this context, nitric oxide, which is generated in increased amounts by OA chondrocytes in situ, suppresses NLRP3 activation."

25266449

---

➶

reach

"Recent studies suggest that nitric oxide (NO), Ca 2+ and cyclic AMP negatively regulate the NLRP3 inflammasome but the detailed mechanisms are unclear XREF_BIBR, XREF_BIBR."

27439607

---

➶

reach

"Nitric oxide (NO) has been reported to negatively regulate NLRP3 inflammasome mediated caspase-1 activation [XREF_BIBR]."

26491223

---

➶

reach

"Since NO is an inhibitor of caspase-1 [XREF_BIBR], availability of NO may inhibit NLRP3 inflammasome activation and subsequent IL-1beta and IL-18 production."

32454788

---

➶

reach

"In this study, we found that NO not only inhibits NLRP3 inflammasome mediated IL-1beta secretion and caspase-1 activation, but also inhibits NLRC4- and AIM-2-mediated IL-1beta secretion and caspase-1 activation (XREF_SUPPLEMENTARY), but to a much less extent (3-fold decrease for NLRC4 and AIM-2, 40-fold decrease for NLRP3)."

23318584

---

➶

reach

"NO thus specifically inhibits NLRP3 inflammasome activation but not the TLR and NF-kappaB signaling pathways."

23318584

---

➶

reach

"It has been reported that NO prevents NLRP3 activation and protects against LPS induced septic shock."

29951054

---

➶

reach

"Interestingly, nitric oxide seems to stabilize mitochondria against dysfunction and suppress NLRP3 activation by S nitrosylation."

25879282

---

➶

reach

"Thus, in both macrophages and transfected 293T cells NO specifically inhibited the assembly and activity of the NLRP3 inflammasome complex."

23160153

---

➶

reach

"It was demonstrated that NO suppresses NALP3 inflammasome activation by nitrosylation of NALP3 proteins resulting in decreased synthesis of mature IL-1 beta and IL-18, impaired Th1 immunity and NK cell activation XREF_BIBR."

23936574

---

➶

reach

"Furthermore, S-nitroso-N-acetylpenicillamine (SNAP), an NO donor, markedly inhibited NLRP3 inflammasome activation, whereas the AIM2 and NLRC4 inflammasomes were only partially inhibited by SNAP."

23100513

---

➶

reach

"Nitric oxide (NO) negatively regulates NLRP3 inflammasome activation through S nitrosylation of NLRP3."

29868015

---

➶

reach

"On the contrary, it is known that NLRP3 inflammasome activity is inhibited by type-1 interferon and nitric oxide [XREF_BIBR]."

32331389

---

➶

reach

"Nitric oxide inhibits human NLRP3 inflammasome activation."

23318584

---

➶

reach

"The findings reported above suggested that exogenous NO donors inhibited NLRP3 inflammasome mediated IL-1beta secretion and caspase-1 activation."

23318584

Dopamine affects NLRP3

| 6 39

Dopamine inhibits NLRP3. 45 / 45

| 6 39

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➶

reach

"These results suggest that autophagy mediates DA induced NLRP3 degradation.We further investigated how DRD1 signaling promotes NLRP3 ubiquitination."

25594175

---

➶

reach

"These results suggest that DA and DRD1 signaling can promote NLRP3 degradation to inhibit inflammasome activation in microglias and astrocytes."

25594175

---

➶

reach

"These studies suggest that dopamine producing neurons and the NLRP3 inflammasome regulate each other in a bidirectional fashion, where the inflammasome can damage these neurons, while dopamine from these neurons can inhibit NLRP3 function."

26121197

---

➶

reach

"These results suggest that DA signals through DRD1 to inhibit inflammasome activation and signals through DRD2 to suppress the transcription proinflammatory cytokines.Next, we asked how DA and DRD1 signaling inhibit NLRP3 inflammasome activation."

25594175

---

➶

reach

"Interestingly, we found that DA treatment induced NLRP3 degradation in a dose- and time dependent manner."

25594175

---

➶

reach

"To determine which receptor was involved in DA induced NLRP3 inflammasome inhibition, these receptors were silenced by small interfering RNA (siRNA) in BMDMs, respectively."

25594175

---

➶

reach

"Previous study reported that the neurotransmitter dopamine inhibited NLRP3 inflammasome activation via dopamine D1 receptor (DRD1)."

29301581

---

➶

reach

"Here, we demonstrate that DA can induce the degradation of NLRP3 protein to inhibit NLRP3 inflammasome and support the recent findings that NLRP3 ubiquitination might play an important role in the regulation of inflammasome activation (Juliana et al., 2012; Py et al., 2013)."

25594175

---

➶

reach

"In addition, dopamine negatively regulates NLRP3 inflammasome via a cAMP dependent manner."

29163487

---

➶

reach

"A recent study reported that dopamine might inhibit NLRP3 inflammasome via the activation of D1DR [43]."

25824241

---

➶

reach

"show that DA inhibits the activation of the NLRP3 inflammasome through D1 receptor (DRD1) signaling."

26321913

---

➶

reach

"Dopamine [XREF_BIBR], MCC950 [XREF_BIBR, XREF_BIBR], and CY-9 [XREF_BIBR] were reported to inhibit the NLRP3 inflammasome based on caspase-1 cleavage and mature IL-1beta release, whereas their inhibition of pyroptosis was not detected."

29807832

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➶

reach

"Further studies showed that knockdown of Chip or Ubr5 by using siRNA did not affect DA induced NLRP3 degradation in BMDMs."

25594175

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➶

reach

"Taken together, our results indicate that DA can negatively regulate NLRP3 inflammasome activation via DRD1 signaling and suggest that DRD1 might be a potential target for treatment of inflammatory diseases.NLRP3 inflammasome mediated IL-1beta production is a two-step process : a primary signal that induces pro-IL-1beta and NLRP3 synthesis and a secondary signal that activates the inflammasome and the subsequent caspase-1 processing (Bauernfeind et al., 2011)."

25594175

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"Interestingly, the neurotransmitter dopamine has also been found to inhibit the NLRP3 inflammasome via dopamine D1 receptor mediated E3-ligase activation that results in the proteasome dependent degradation of NLRP3 [XREF_BIBR]."

27942750

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➶

reach

"In a recent study by Yan et al. [XREF_BIBR], the authors found that dopamine inhibits the NLRP3 inflammasome through the dopamine D1 receptor."

28870209

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➶

sparser

"Importantly, DA-induced NLRP3 inflammasome inhibition could be blocked by KH7, an ADCY inhibitor ( Figures 4 D and 4E), suggesting that DA-induced NLRP3 inflammasome inhibition is cAMP-dependent."

25594175

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➶

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"It also showed that DRD1 plays a primary role, while DRD2, DRD3, and DRD4 have no roles in dopamine mediated NLRP3 inflammasome inhibition [XREF_BIBR]."

29301581

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➶

reach

"In addition, dopamine significantly inhibited ventilation induced NLRP3 activation."

28189055

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➶

reach

"These results indicate that the increase of cAMP in cells can promote NLRP3 ubiquitination and degradation.Protein kinase A (PKA) and exchange protein activated by cAMP (EPAC) are the two known sensors for intracellular cAMP, so we tested whether they were involved in DA induced NLRP3 inflammasome inhibition (Gloerich and Bos, 2010)."

25594175

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➶

reach

"These results suggest that DA inhibits NLRP3 inflammasome activation primary through DRD1."

25594175

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➶

reach

"Here, we report that the neurotransmitter dopamine (DA) inhibits NLRP3 inflammasome activation via dopamine D1 receptor (DRD1)."

25594175

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➶

reach

"DA, via the type-1 DA receptor-1 (DRD1) and cyclic AMP signaling, inhibits the NLRP3 inflammasome [XREF_BIBR]."

| PMC

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➶

reach

"Our results showed that autophagy inhibitor 3-Methyladenine (3-MA) could suppress DA induced NLRP3 degradation, while proteasome inhibitor MG132 could not, suggesting that ubiquitinated NLRP3 is degraded via autophagy."

25594175

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➶

reach

"The results showed that inhibition of PKA with H89 did not affect DA induced NLRP3 inflammasome inhibition or DA promoted NLRP3 degradation."

25594175

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➶

reach

"The reported physiological concentration of DA might be much lower than the actual concentration.Collectively, our results demonstrate that DA and DRD1 signaling can suppress NLRP3 inflammasome activation and identify an endogenous regulatory mechanism for NLRP3 inflammasome related inflammation."

25594175

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➶

reach

"Dopamine signals inhibit NLRP3 inflammasome activation through DRD1 and suppress the transcription proinflammatory cytokines through DRD2."

28878677

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➶

sparser

"Here, our results show that DRD1 plays a primary role and DRD5 plays a minor role, while DRD2, DRD3, and DRD4 have no roles in DA-induced NLRP3 inflammasome inhibition."

25594175

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➶

reach

"Interestingly, dopamine was found to negatively regulate NLRP3 activation in both primary microglia and astrocytes via a dopamine D1 receptor (DRD1)-cyclic adenosine monophosphate (cAMP) signaling pathway 85."

26121197

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➶

reach

"NLRP3 dependent caspase-1 activation and IL-1beta maturation by nigericin were indeed inhibited by DA in a dose dependent manner."

25594175

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➶

sparser

"To determine which receptor was involved in DA-induced NLRP3 inflammasome inhibition, these receptors were silenced by small interfering RNA (siRNA) in BMDMs, respectively ( Figures S2 A and S2B)."

25594175

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➶

reach

"Taken together, our findings indicated that dopamine may negatively regulate NLRP3 inflammasome activation via DRD1 signaling and suggested that DRD1 might be a potential target for treatment of ICH induced inflammation."

29301581

---

➶

reach

"They also reported that dopamine suppresses NLRP3 inflammasome activation to control systemic inflammation [XREF_BIBR]."

27366746

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➶

reach

"Dopamine does not inhibit NLRP3 inflammasome activation in MARCH7 deficient macrophages."

29868015

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➶

sparser

"Although DRD2 was not involved in DA-induced NLRP3 inflammasome inhibition, a previous report has shown that DRD2 signaling also has a protective role in MPTP-induced loss of the dopaminergic neurons ( Shao et al., 2013 )."

25594175

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➶

reach

"Importantly, DA induced NLRP3 inflammasome inhibition could be blocked by KH7, an ADCY inhibitor, suggesting that DA induced NLRP3 inflammasome inhibition is cAMP dependent."

25594175

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➶

reach

"Further study showed that DA induced NLRP3 degradation was inhibited in Drd1 -/- macrophages, suggesting that DA promotes NLRP3 degradation via DRD1 signaling."

25594175

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➶

sparser

"The results showed that inhibition of PKA with H89 did not affect DA-induced NLRP3 inflammasome inhibition or DA-promoted NLRP3 degradation ( Figures S4 B and S4C)."

25594175

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➶

reach

"However, knockdown of March7 could rescue DA induced NLRP3 degradation in BMDMs."

25594175

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➶

reach

"Although DRD2 was not involved in DA induced NLRP3 inflammasome inhibition, a previous report has shown that DRD2 signaling also has a protective role in MPTP induced loss of the dopaminergic neurons (Shao et al., 2013)."

25594175

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➶

sparser

"Protein kinase A (PKA) and exchange protein activated by cAMP (EPAC) are the two known sensors for intracellular cAMP, so we tested whether they were involved in DA-induced NLRP3 inflammasome inhibition ( Gloerich and Bos, 2010 )."

25594175

---

➶

reach

"Here, we report that the neurotransmitter dopamine (DA) inhibits NLRP3 inflammasome activation via dopamine D1 receptor (DRD1)."

25594175

---

➶

reach

"Taken together, these results demonstrate that DA specifically inhibits NLRP3 inflammasome activation and subsequent IL-1beta production.Next, we investigated the mechanisms underlying the inhibitory activity of DA on NLRP3 inflammasome activation."

25594175

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➶

reach

"Another recent study found that DA inhibits the pro inflammatory NLRP3 inflammasome response via the activation of the DA D1 receptor [XREF_BIBR]."

31940997

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➶

reach

"In this respect, dopamine was found to inhibit NLRP3 activation in both primary microglia and astrocytes through a dopamine D1 receptor-cyclic AMP signaling pathway XREF_BIBR."

28902711

Curcumin affects RELA

6 | 2 36

Curcumin inhibits RELA. 44 / 44

6 | 2 36

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"The supershift assay showed that TNFalpha increases neuroblastoma NF-kappaB activity through the canonical pathway, specifically through increases in the p50 and p65 subunits; curcumin blocked the p50 and p65 subunit activation as seen by antibody shift (XREF_FIG)."

22284765

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➶

reach

"Moreover, the nuclear NF-kappaB and p65 protein abundance were also decreased by curcumin."

27297427

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➶

reach

"In addition, curcumin reduced the expression of the positive regulators of DNMT1, p65 and Sp1, which correlates with reductions in the binding of these transcription factors to the DNMT1 promoter in AML cell lines, demonstrating the promise of curcumin as a potential treatment for AML [XREF_BIBR]."

26457241

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➶

reach

"Curcumin also suppressed NF-kappaB reporter activity induced by tumor necrosis factor receptor (TNFR) 1, TNFR2, NF-kappaB-inducing kinase, IkappaB kinase complex (IKK), and the p65 subunit of NF-kappaB."

16219905

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➶

reach

"Finally, curcumin tended to decrease p65 nuclear localization at 50 microM (p> 0.05 vs. vehicle + LPS)."

22197802

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➶

medscan

"Treatment with curcumin reversed Tat-induced dissociation of HDAC1 from long terminal repeat region; and curcumin caused a decline in the binding of p65/NFκB to long terminal repeat region promoters stimulated by Tat."

21344388

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➶

reach

"Additionally, curcumin reduced the nuclear localization of p65."

27777559

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➶

reach

"This high dose could be a more effective dose of curcumin supplementation to reduce the diabetes induced vascular NF-kappaB p65 and COX-2 upregulation."

21437112

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➶

reach

"However, translocation of NF-kappaBp65 was markedly blocked in the mice treated with DSS plus nanoparticle curcumin."

28985227

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➶

ctd

No evidence text available

16173963

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➶

reach

"Curcumin blocks the positive regulators of DNMT1, p65 and Sp1 decreasing their activity for binding to the promoter region of DNMT1."

30881375

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➶

reach

"Curcumin supplementation in Hp + curI and Hp + curII groups significantly decreased NF-kappaB p65 immunoreactive cells and macromolecular leakage compared with results in the Hp group."

20731017

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➶

reach

"We found that NF-kappaB was constitutively active in all human MM cell lines examined and that curcumin, a chemopreventive agent, down-regulated NF-kappaB in all cell lines as indicated by electrophoretic mobility gel shift assay and prevented the nuclear retention of p65 as shown by immunocytochemistry."

12393461

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➶

reach

"Curcumin inhibits p65 and cell invasion by downregulation of COX-2 and MMP-2 expression [XREF_BIBR]; by suppression of gene expression of EGFR and modulation of Akt and mTOR signaling, and inhibition of cell growth [XREF_BIBR, XREF_BIBR]."

22583408

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➶

medscan

"Interestingly, curcumin pretreatment of drug-resistant cells alleviated SMAR1-mediated p65NFκB activation and hence restored doxorubicin sensitivity."

22013068

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➶

ctd

No evidence text available

16023083

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➶

ctd

No evidence text available

18226269

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➶

reach

"Mechanistically, curcumin reduced the expression of positive regulators of DNMT1, p65 and Sp1, which correlated with a reduction in binding of these transcription factors to the DNMT1 promoter in AML cell lines."

23457487

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➶

reach

"Our findings indicate that curcumin can effectively lower the elevated levels of HIF-1alpha and nuclear p65 (Rel A) in breast and lung cancer cells under a hypoxic tumour micro-environment when delivered in nanoparticulate form."

29065834

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➶

reach

"Results confirmed that curcumin attenuates activation of beta-catenin and NFkappaBp65 and reduces relative expression of stem cell markers."

24626093

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➶

ctd

No evidence text available

18593918

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➶

reach

"To investigate the role of NF-kappaB in modulating cell survival, both the pharmacological inhibitor of NF-kappaB, curcumin, and RNA interference targeting p65 were used in the current study."

18811964

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reach

"The present data show that curcumin prevented the activation of c-Rel and p65, which is essential for TF gene activation in endothelial cells, by impairing the proteolytic degradation inhibitor protein, I kappa B alpha."

9437186

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➶

ctd

No evidence text available

12216086

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➶

reach

"Curcumin also reduced NF-kappaB transcriptional factor RELA (p65), as well as oncogenic STAT3 and EGFR mRNAs in neutral bile, acid alone and neutral control treated cells (P <.01, by t test; means +/-SD; multiple comparisons by Holm-Sidak)."

29911313

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➶

reach

"Compared to controls, the presence of p65 in the nuclear fraction was markedly decreased in cells treated with curcumin alone or with curcumin and docetaxel (XREF_FIG)."

24741455

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➶

reach

"Curcumin completely abolished a hyperosmoticity induced increase of NF-kappaB p65."

20026325

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➶

reach

"I kappa B alpha, a previously identified NF-kappa B inducible gene, was overexpressed in human pancreatic tumor tissues and cell lines, and RelA activation could be inhibited by curcumin and dominant negative mutants of I kappa B alpha, raf, and MEKK1."

9918209

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➶

reach

"Moreover, curcumin was proved to suppress the p38, JNK and NF-kappaB p65 in human intestinal epithelial HT29 cell line."

20885979

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➶

reach

"However, pretreatment with PGE 2 attenuated curcumin induced inhibition of p50, p65, and RelB of NF-kappaB signaling (XREF_FIG)."

25431425

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➶

reach

"Correspondingly, we found that radiation induced increased NF-kappaB p65 immunoreactivity was decreased by curcumin (XREF_FIG)."

23946685

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➶

ctd

No evidence text available

18640131

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reach

"As shown in XREF_FIG, curcumin treatment for 24 h time-dependently reduced the activation of different NF-kappaB subunits (p50 and p65)."

25431425

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➶

reach

"Because treatment of septic rats with curcumin in vivo reduced NF-kappaB and p65 activity in skeletal muscle (XREF_FIG), we tested whether a similar mechanism may be involved in the direct effect of curcumin in septic muscle."

18389075

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➶

reach

"In addition, the RT-PCR analysis revealed that curcumin suppressed the macrophage marker F4/80, dendritic cell and M1 macrophage marker CD11c and oxidative stress sensitive transcription factor NF-kappaB p65 (encoded by Rela; Fig."

29899429

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➶

reach

"Curcumin treatment blocked activation of p50 and p65, which was significantly activated by pretreatment with 1 muM PGE 2 for 2 h (XREF_FIG)."

25431425

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➶

reach

"We provide evidence that curcumin suppresses p65, a transcription factor known to regulate FABP5."

25260874

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➶

reach

"Furthermore, curcumin substantially suppressed the expression of the oxidative stress inducible transcription factor NF-kappaB p65 and NF-kappaB-regulated ALOX5 in eWAT of obese mice XREF_BIBR - XREF_BIBR."

29899429

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➶

reach

"As shown in XREF_FIG, levels of nuclear p65 were decreased in all cases when HT29 cells were treated with OXA plus Curcumin as compared with OXA alone."

27091625

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reach

"They have concluded that curcumin reduced the expression and transcriptional activity of NF-kappaB p65 protein and decreased the levels of the Recepteur d'Origine Nantais tyrosine kinase (RON) [XREF_BIBR]."

27834913

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➶

reach

"Both the pharmacologic inhibitor of NF-kappaB, curcumin, and RNA interference targeting p65 were used to block NF-kappaB signaling in HBECs."

18811964

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➶

reach

"Curcumin prevents NF- kappaB and p65 phospohorylation at serine 536 and its acetylation through p300 inhibition [XREF_BIBR]."

25152696

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➶

reach

"Compared with the LPS group, p65 was down-regulated by curcumin, with statistically significant difference (P < 0.05)."

27916071

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➶

reach

"Curcumin and PGV-1 but not PGV-0 decreased localization of p65 into the nucleus induced by Dox, indicating that activation of NF- kB was inhibited."

24528023

Bortezomib affects NFKBIA

| 1 1 41

Bortezomib inhibits NFKBIA. 43 / 43

| 1 1 41

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➶

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"Our data suggest that bortezomib treatment not only induces IkappaB-alpha degradation, NF-kappaB inhibition and independent apoptosis induction, but also strongly enhances TRAIL mediated cytotoxicity in malignant human glioma cell lines."

21220502

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➶

reach

"Bortezomib was shown to activate IKKbeta and decrease the abundance of IkappaBalpha, thereby increasing canonical NF-kB activity in myeloma cells; 23 however, this was not reproducible in T-ALL cells."

24301524

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➶

reach

"To this end, Hut-78 cells were transfected with non silencing or IkappaBalpha siRNA, treated with increasing concentrations of bortezomib as described above, and apoptosis was measured by a quantitative ELISA assay based on the detection of nucleosome release into the cytoplasm."

21224428

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➶

reach

"Because Bortezomib induced degradation of IkappaBalpha, we investigated whether this proteasome inhibitor by itself can activate NF-kappaB in leukemia cells."

| PMC

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➶

medscan

"Immuno-precipitation results showed that bortezomib reduced the interaction between NF-κB RelA/p65 and I-κBα and co-treatment with chloroquine prevented bortezomib-induced disruption of NF-κB and I-κBα binding ( )."

22393418

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➶

reach

"Conversely, bortezomib downregulated IkappaBalpha at early time points (XREF_FIG)."

29386876

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➶

reach

"However, our results demonstrated that treatment with bortezomib induced I-kappaBalpha degradation in DLBCL cell lines as well as in primary FL and DLBCL cells, in agreement with the finding by Hideshima and colleagues in multiple myeloma cells XREF_BIBR."

22393418

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➶

reach

"On the opposite, bortezomib induces the calpain dependent degradation of IkappaBalpha by activating the ubiquitous calpains."

21244345

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➶

reach

"The autophagy inhibitor chloroquine (CQ) significantly inhibited bortezomib induced I-kappaBalpha degradation, increased complex formation with NF-kappaB and reduced NF-kappaB nuclear translocation and DNA binding activity."

22393418

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➶

reach

"Taken together, these results demonstrate that bortezomib induces canonical NF-kappaB activation by triggering the autophagic degradation of I-kappaBalpha."

22393418

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➶

reach

"By inhibiting the degradation of cytoplasmic IkappaBalpha, bortezomib inhibits the activation of NF-kappaB."

20828898

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➶

reach

"At first, it was thought that bortezomib prevented IkappaBalpha from degradation and inhibited the nuclear factor kappa B (NF-kappaB) pathway in myeloma [XREF_BIBR]."

29518205

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➶

reach

"14 Intriguingly, addition of BafA1 attenuated the ST80 and Bortezomib triggered degradation of IkappaBalpha protein, whereas it did not block NIK accumulation, phosphorylation of IkappaBalpha and p65 or acetylation of histone H3 (XREF_FIG)."

25766331

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➶

reach

"Bortezomib induced I-kappaBalpha degradation decreased its complex formation with NF-kappaB and increased NF-kappaB nuclear translocation and therefore its DNA binding activity."

22393418

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➶

reach

"We demonstrate that bortezomib induces I-kappaBalpha degradation which is removed by the autophagic process and activates NF-kappaB transcriptional activity."

22393418

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➶

reach

"This suggests that bortezomib induced I-kappaBalpha degradation is not occurring through the UPS pathway XREF_BIBR."

22393418

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➶

reach

"Since we observed that ST80 and Bortezomib cotreatment triggers the degradation of IkappaBalpha (XREF_FIG), we next asked how IkappaBalpha is degraded when the proteasome is inhibited by Bortezomib."

25766331

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➶

reach

"While our previous results showed that Bortezomib inhibits TNF induced degradation of IkappaBalpha protein (XREF_FIG), we paradoxically found that Bortezomib by itself induced the degradation of IkappaBalpha in a dose (XREF_FIG) and time dependent manner (XREF_FIG)."

| PMC

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➶

reach

"It has been shown that bortezomib inhibits proteasomal degradation of IkappaBalpha induced by cytokines (i.e., TNFalpha); however, IkappaBalpha was downregulated in both cell lines by bortezomib treatment, associated with enhanced phosphorylation in breast cancer cells."

24481412

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➶

reach

"We found that the combination treatment of an XPO1 inhibitor (selinexor) and a PI (bortezomib) synergistically increased IkappaBalpha more than single-agent selinexor or bortezomib treatment in both parental and PI resistant MM cell lines and in patient myeloma cells."

27806331

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➶

reach

"Bortezomib may prevent the dissociation of IkappaBalpha from NF-kappaB so that the NF-kappaB in the cytosol remains in the state of IkappaBalpha binding."

28663117

---

➶

reach

"In the presence of bortezomib, CQ prevented bortezomib induced I-kappaBalpha degradation but not I-kappaBalpha phosphorylation."

22393418

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➶

reach

"Bortezomib induced I-kappaBalpha degradation was also observed in primary FL and DLBCL cells (XREF_FIG)."

22393418

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➶

reach

"In summary, here we report, for the first time, that bortezomib induced I-kappaBalpha degradation in DLBCL cells may be due to activated autophagy."

22393418

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➶

reach

"Our results demonstrate that bortezomib induced IkappaBalpha degradation occurred in conjunction with the activation of caspase-8; moreover, the decrease in IkappaBalpha level was prevented in a dose dependent manner by the addition of z-IETD, a specific inhibitor of caspase-8."

16733806

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➶

reach

"Inhibition of IKKbeta blocks bortezomib induced IkappaBalpha down-regulation and NF-kappaB activation."

24481412

---

➶

reach

"We therefore tested whether bortezomib induced I-kappaBalpha degradation also occurs in DLBCL cells and whether this degradation is associated with enhanced autophagy."

22393418

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➶

reach

"Bortezomib downregulates the IkappaBalpha protein."

24481412

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➶

reach

"Blocking autophagy by CQ potentiates bortezomib induced accumulation of I-kappaBalpha and DLBCL cell death."

22393418

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➶

reach

"Correction : Proteasome inhibitor PS-341 (bortezomib) induces calpain dependent IkappaBalpha degradation."

32591445

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➶

reach

"Interestingly, inhibition of lysosomal activity by Bafilomycin A1 inhibits ST80 and Bortezomib stimulated IkappaBalpha degradation, NF-kappaB activation and BAG3 upregulation, indicating that IkappaBalpha is degraded via the lysosome in the presence of Bortezomib."

25766331

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➶

reach

"We have shown that fenretinide reduces expression of IKK, which may to some degree abrogate the effect that bortezomib has on calpain mediated degradation of IkappaBalpha."

26237500

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➶

reach

"The proteosomal inhibitor, bortezomib, suppresses NF-kappaB signaling by preventing IkappaBalpha degradation and is reported to reduce synovial macrophage inflammatory activity in experimental murine collagen arthritis [XREF_BIBR] but, again, is not specifically targeted to the macrophage."

21324111

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➶

reach

"So the decreased IkappaB-alpha protein level in JurkatB5 cells treated with bortezomib indicated an upregulation of NF-kappaB activity after bortezomib treatment, resulting in the suppression of apoptosis."

18562081

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➶

reach

"Hideshima et al. found that bortezomib triggers the canonical pathway of NF-kappaB and downregulates IkappaBalpha in primary cells from patients with MM."

26075279

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➶

reach

"We found that Bortezomib degrades p65 and IkappaBalpha through different mechanisms."

| PMC

---

➶

reach

"Previous studies demonstrated that degradation of IkappaBalpha by Bortezomib leads to NF-kappaB activation [XREF_BIBR, XREF_BIBR]."

| PMC

---

➶

eidos

"However , in MM cell lines and primary tumor cells from MM patients , bortezomib significantly down-regulated IkappaBalpha expression and induced NF-kappaB activation [ 135 ] ."

29486318

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➶

reach

"Immuno precipitation results showed that bortezomib reduced the interaction between NF-kappaB RelA and p65 and I-kappaBalpha and co-treatment with CQ prevented bortezomib induced disruption of NF-kappaB and I-kappaBalpha binding (XREF_FIG)."

22393418

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➶

reach

"The observation that bortezomib reduced IkB-alpha levels in human glioma cells is novel and, these findings are consistent with previous studies demonstrating that PS-341 as well other proteasome inhibitors induce IkB-alpha degradation in endometrial carcinoma cell lines, HepG2 liver cancer cell line, multiple myeloma cells and other tumor types."

21220502

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➶

reach

"In line with our observations, another study demonstrated differential effects of bortezomib on NFkappaB activity depending on different cell types : bortezomib triggered NFkappaB activity via the canonical pathway in peripheral blood mononuclear cells by enhancing non proteosomal degradation of IkappaBalpha while NFkappaB activation was inhibited in bone marrow derived stromal cells [39]."

26494122

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➶

reach

"This conclusion is based on our data showing that impairment of lysosomal acidification by the V-ATPase inhibitor BafA1 prevents ST80 and Bortezomib stimulated IkappaBalpha degradation, NF-kappaB activation and BAG3 upregulation."

25766331

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➶

reach

"In our study, Bortezomib degraded not only IkappaBalpha protein but also the p65 subunit of NF-kappaB."

| PMC

Lipopolysaccharide affects NLRP3

| 42

Lipopolysaccharide inhibits NLRP3. 42 / 42

| 42

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➶

reach

"A COX-2 and sEH dual inhibitor PTUPB alleviates lipopolysaccharide induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation."

32308747

---

➶

reach

"Silencing RIP3 mRNA inhibited LPS induced NLRP3 inflammasome activation."

30126430

---

➶

reach

"S nitrosylation of the NLRP3 inflammasome proteins, such as NLRP3 and caspase-1, is decreased by these G-Rg3 isomers in LPS stimulated peritoneal macrophages and BMDMs."

29021688

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➶

reach

"Since there is no effective treatment strategy to reduce ARDS associated lung injury and fibrosis, it could be suggested that pirfenidone could attenuate lung injury based on published data showing that pirfenidone reduces LPS induced acute lung injury and subsequent fibrosis by suppressing NLRP3 inflammasome activation (34)."

32765748

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➶

reach

"Pirfenidone ameliorates lipopolysaccharide induced pulmonary inflammation and fibrosis by blocking NLRP3 inflammasome activation."

29783158

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➶

reach

"However, based on our findings, specifically data on IRAK-2 and NLRP3 expression after treatment with Bay11-7082 and IRAK inhibitors in cells treated with LPS for 30 min, showed that acute inflammatory reactions are not completely NF-kappaB-independent."

26615974

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➶

reach

"We found that PGE 2 added after LPS priming decreased NLRP3 inflammasome activation via a cAMP dependent mechanism as assessed by the decrease in mature IL-1beta and mature caspase-1 release, and IL-18 release, as well as a decrease in ASC oligomerization."

25917098

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➶

reach

"Baicalin attenuates lipopolysaccharide induced renal tubular epithelial cell injury by inhibiting the TXNIP and NLRP3 signalling pathway via increasing miR-223-3p expression."

32392921

---

➶

reach

"Furthermore, knockdown of NLRP3 considerably attenuated the increase of IL-1beta secretion in SIRT1-knockdown cells treated with LPS."

32188057

---

➶

reach

"Fraxin ameliorates lipopolysaccharide induced acute lung injury in mice by inhibiting the NF-kappaB and NLRP3 signalling pathways."

30530164

---

➶

reach

"The inhibitory effect of HSYA on XO activity contributes to the ROS scavenging and NLRP3 inflammation suppression triggered by LPS, leading to decreased IL-1beta and IL-18 secretion in RAW264.7 macrophages (XREF_FIG)."

27433030

---

➶

reach

"Not surprisingly, resveratrol, the polyphenol present in the skin of grapes, another sirtuin activator, also inhibits NLRP3 inflammasome activation in mice by preserving mitochondrial function, and protects against hepatosteatosis, renal inflammation and LPS induced lung injury [XREF_BIBR - XREF_BIBR]."

27942750

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➶

reach

"These results indicated that liraglutide pre-treatment attenuated LPS induced ALI by inhibiting the NLRP3 inflammasome pathway."

27756605

---

➶

reach

"Our observation that both high extracellular K + levels or a selective K + channel inhibitor significantly suppresses IL-1beta production suggests that the purogenic P2X 7 ATP gated ion channel is involved in LPS induced NLRP3 inflammasome activation in HDPFs."

25684031

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➶

reach

"Green tea polyphenols prevent lipopolysaccharide induced inflammatory liver injury in mice by inhibiting NLRP3 inflammasome activation."

31187838

---

➶

reach

"Overall, fraxin played a protective role in LPS induced lung injury by inhibiting the NF-kappaB and NLRP3 signalling pathways."

30530164

---

➶

reach

"We treated LPS primed WT and Trem2 -/- BMDMs with nigericin to activate canonical NLRP3 inflammasome, and found that caspase-1 cleavage and IL-1beta maturation were indeed promoted in TREM2 deficient BMDMs, suggesting TREM2 may suppress the NLRP3 inflammasome."

29887864

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➶

reach

"The TCMD treatment of LPS primed bone marrow derived macrophages (BMDMs) and human trophoblast cells attenuated NLRP3 inflammasome activation induced by inflammasome activators such as ATP, nigericin, and monosodium urate (MSU)."

32410829

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➶

reach

"Paeoniflorin relieves LPS induced inflammatory pain in mice by inhibiting NLRP3 inflammasome activation via transient receptor potential vanilloid 1."

32083340

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➶

reach

"Silybin attenuates LPS induced lung injury in mice by inhibiting NF-kappaB signaling and NLRP3 activation."

28350048

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➶

reach

"LPS plus ATP stimulation substantially increased translocation of NLRP3 into mitochondrial fraction and IL-4 diminished this mitochondrial redistribution of NLRP3 (XREF_FIG)."

25601272

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➶

reach

"Dihydromyricetin attenuates Escherichia coli lipopolysaccharide induced ileum injury in chickens by inhibiting NLRP3 inflammasome and TLR4 and NF-kappaB signalling pathway."

32448367

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➶

reach

"Our findings have, for the first time, revealed the novel mechanism underlying the inhibitory effect of molecular hydrogen on LPS caused NLRP3 inflammasome activation, highlighting the promising application of this new antioxidant in the treatment of LPS associated inflammatory pathological damage."

26488087

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➶

reach

"Type I IFNs and long-term LPS stimulation were shown to negatively regulate NLRP3 activation."

23100513

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➶

reach

"In order to address the molecular mechanism underlying the suppression of NLRP3 inflammasome activation by celastrol, cells were treated with celastrol after LPS stimulated in the later experiments."

28978034

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➶

reach

"Recent studies have revealed a crucial protective role of LPS induced ALI in vitro and in vivo by inhibiting activation of the NLRP3 inflammasome (Jiang et al., 2016; Xiang et al., 2015; Zhou et al., 2016)."

28654770

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➶

reach

"Taken together, the administration of PFD reduced LPS induced lung inflammation and fibrosis by blocking NLRP3 inflammasome activation and subsequent IL-1beta secretion."

29783158

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➶

reach

"Dexmedetomidine alleviates lipopolysaccharide induced acute kidney injury by inhibiting the NLRP3 inflammasome activation via regulating the TLR4/NOX4/NF-kappaB pathway."

31243816

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➶

reach

"Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury by targeting NLRP3 via miR-381."

30102002

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➶

reach

"However, sustained NLRP3 inflammasome activity is inhibited both by long-term LPS priming as well as inflammation induced type I interferon (IFN) [XREF_BIBR]."

30042333

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➶

reach

"Our present study demonstrated that KM inhibited LPS and ATP induced pyroptosis and the release of IL-1beta/18 in J774A.1 cells by inhibiting the activation of GSDMD and caspase-1 and the assembly of NLRP3 inflammasome."

30952097

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➶

reach

"Our data showed that P. gingivalis LPS down-regulated NLRP3, IL-1beta precursor (pro-IL-1beta) and mature IL-1beta under normoxia."

29184853

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➶

reach

"65 Thus, incubation of LPS stimulated macrophages with an IKK inhibitor, Bay11-7082, blocks NLRP3 induction and caspase 1 activation by ATP."

29158945

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➶

reach

"LPS exposure reduces the ubiquitin mediated proteasomal processing of NALP3 by inducing levels of an E3 ligase component, FBXO3, which targets FBXL2."

26037928

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➶

reach

"Atractylodin attenuates lipopolysaccharide induced acute lung injury by inhibiting NLRP3 inflammasome and TLR4 pathways."

29551284

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➶

reach

"Importantly, Lee et al showed that Ca 2+ signaling inhibitors, including an inhibitor of the IP 3 R, blocks LPS mediated NLRP3 inflammasome activation in CAPS PBMCs, and that CAPS mutations decrease cAMP binding [XREF_BIBR]."

24646829

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➶

reach

"IL-17A itself can induce the activation of NLRP3 inflammasome, whereas IL-17A neutralization attenuates LPS induced NLRP3 overactivation [29, 41]."

29336982

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➶

reach

"Morin alleviates LPS induced mastitis by inhibiting the PI3K and AKT, MAPK, NF-kappaB and NLRP3 signaling pathway and protecting the integrity of blood-milk barrier."

31711938

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➶

reach

"In conclusion, DEX attenuated LPS induced AKI by inhibiting oxidative stress damage and NLRP3 inflammasome activation via regulating the TLR4/NOX4/NF-kappaB pathway, mainly acting on the alpha 2 AR rather than IR."

31243816

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➶

reach

"Aloin suppresses lipopolysaccharide induced acute lung injury by inhibiting NLRP3 and NF-kappaB via activation of SIRT1 in mice."

32419528

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➶

reach

"Genipin alleviates LPS induced acute lung injury by inhibiting NF-kappaB and NLRP3 signaling pathways."

27262946

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➶

reach

"In summary, DHM attenuated the ileum mucosal damage, oxidative stress and apoptosis, maintained barrier function, inhibited NLRP3 inflammasome and TLR4 and NF-kappaB signalling pathway activation triggered by Escherichia coli LPS."

32448367

Anthra[1,9-cd]pyrazol-6(2H)-one affects JUN

| 12 4 26

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits JUN. 42 / 42

| 12 4 26

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➶

reach

"SP600125 inhibited AP-1 and c-Jun."

21046201

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➶

reach

"To further study the functions of transcription factors under hypoxic conditions, JSH-23 and SP600125 were used to block the NF-kappaB and AP-1 and c-Jun pathways."

24002703

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➶

reach

"As shown in XREF_FIG, SP600125 prevented the cerebral ischemia activation of JNK and c-Jun, an effect that was correlated with a significant attenuation of the induction of Dkk1."

18716201

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➶

medscan

"The phosphorylation of JNK (0.48 +/- 0.03) and the phosphorylation of c-Jun (0.46 +/- 0.04) significantly increased in the P. vulgaris group (P < 0.05) and SP600125 inhibited the phosphorylation of c-Jun (0.43 +/- 0.01)."

20450729

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➶

reach

"In previously published experiments, 10 muM SP600125 effectively inhibits 90 to 100% of Jun N-terminal kinase activity (Bennett et al., 2001)."

16716376

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➶

reach

"To test this possibility, the CXCL14 overexpressing cells (clone H) were incubated with the c-Jun-NH 2 -kinase (JNK) inhibitor SP600125 to block c-Jun (a component of AP-1) activation and then tested if this would cause a decrease of CXCL14 transcription."

19276362

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➶

reach

"Administration of the JNK inhibitor SP600125 or MLK3 (an upstream kinase of MKK7 or MKK4) inhibitor CEP11004 greatly abrogated c-Jun and proliferation, suggesting that the MLK3-MKK4 or 7-JNK cascade contributes to c-Jun activation and cell viability and proliferation."

26734995

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➶

reach

"Immunoprecipitation assay showed that hyperosmolarity increased the association of nuclear Sp1 with c-Jun, which was inhibited by U0126 and SP600125."

23816505

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➶

reach

"Thrombin (0.3-3.0 U/mL) increased activator protein-1 (AP-1)-luciferase activity, which was inhibited by the JNK inhibitor SP600125."

22212430

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➶

reach

"We have determined that SP600125 blocked c-Jun activation in B leukemia cell lines."

21702955

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➶

reach

"Moreover, the present study showed that IL-17A induced the nuclear translocation of c-Jun and c-Fos, which could be effectively inhibited by the JNK inhibitor SP600125 or the p38 inhibitor SB203580."

26988982

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➶

reach

"This rescue depended on PDGF mediated JNK signaling because SP600125 treatment abolished the induction of c-Jun expression (XREF_FIG B)."

20499359

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➶

reach

"In addition, mature oocytes only present a moderate increase of Jun kinase activity, which is not inhibited by SP600125."

27297883

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➶

reach

"To clarify the signaling pathways underlying the BDNF expression changes due to Kir4.1 knockdown, astrocytes were pretreated with U0126 [a non competitive inhibitor of mitogen activated protein kinase (MEK) 1/2, 10 muM], SB202190 (an inhibitor of p38 MAPK, 10 muM), or SP600125 [an inhibitor of Jun amino-terminal kinase (JNK), 10 muM] for 30 min before the transfection with Kir4.1 siRNA or a negative control."

29358904

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➶

medscan

"In addition, we further demonstrated that the c-Jun N-terminal kinase inhibitor SP600125 and extracellular signal-regulated protein kinase inhibitor U0126 blocked the c-Jun activity and abolished hypoxia-induced 37-kDa laminin receptor precursor expression and promoter activity in a concentration-dependent manner."

28618937

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➶

medscan

"JNK inhibitor SP600125, which inhibits JNK phosphorylation of c-Jun, and to a lesser degree inhibits mitogen activated protein kinase kinase 4 (MKK4) phosphorylation of JNK ( ), had a modest reduction of JNK phosphorylation when used at a concentration of 20 µM ( )."

20336759

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➶

sparser

"TGFβ also induced phosphorylation of (S351) NR4A1, JNK1, c-jun and c-fos which was also inhibited by SP600125, demonstrating that TGFβ induces JNK and genes downstream from JNK."

30072581

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➶

sparser

"In this study, we also showed that SP600125 dramatically inhibited Cd-activated c-Jun, a substrate of JNK in the cells ( xref )."

28129433

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➶

reach

"To investigate whether the JNK and c-jun and mTOR pathways were involved in mediating the protective functions of 14,15-EET during OGD induced injury, RAPA and SP600125 were used to block the mTOR and JNK and c-jun pathways, respectively."

29081082

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➶

medscan

"Treatment of MDA-MB-231 cells with the JNK-specific inhibitor SP600125 or expression of the c-Jun dominant negative inhibitor TAM67 blocked the oligoamine-activated JNK/c-Jun pathway and enhanced oligoamine-inhibited ERalpha expression, suggesting that AP-1 is a positive regulator of ERalpha expression and that oligoamine-activated JNK/AP-1 activity may antagonize the down-regulation of ERalpha induced by oligoamines."

16679312

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➶

reach

"SP600125 has been shown to inhibit Jun N-terminal kinases (JNKs) and other kinases."

24901709

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➶

medscan

"Furthermore, CSE-induced p300 and c-Jun complex formation was inhibited by pretreatment with diphenyleneiodonium chloride, apocynin, N-acetyl-L-cysteine or SP600125."

21268080

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➶

sparser

"Furthermore, inhibition of c-Jun N -terminal kinase (JNK) by SP600125 led to a dramatic decrease of the GLP-induced apoptosis."

24857920

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➶

medscan

"The VRK1 protein phosphorylates c-Jun with a Km of 0.4 muM, and is not inhibited by SP600125."

15378002

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➶

reach

"In this study, we also showed that SP600125 dramatically inhibited Cd activated c-Jun, a substrate of JNK in the cells (XREF_FIG)."

28129433

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➶

medscan

"TNF-α-mediated AP-1-luciferase activity and c-Jun binding to the AP-1 element were inhibited by TNFR1 antibody, thioredoxin, SP600125, and SB203580."

22711527

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➶

reach

"Although the SP600125 inhibitor efficiently suppresses activation of c-Jun and the upregulation of ATF-3 in sensory neurons [XREF_BIBR], it did not inhibit neither c-Jun activation nor ATF-3 upregulation in SCs."

24877090

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➶

reach

"Further, the inhibitors SB202190 (Sigma-Aldrich) and SP600125 (Sigma-Aldrich) were used to block p38 mitogen activated protein kinase (p38-MAPK) and Jun N-terminal kinase (JNK) respectively in control and siPrdx2 transfected HTR8 cells."

28661480

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➶

medscan

"U0126 inhibits c-Fos signaling pathway, and SP600125 inhibits c-Jun signaling pathway, in JFH1 and in H77s cells. 10 µM c-Fos inhibitor (U0126) or 20 µM c-Jun inhibitor (SP600125) was added to JFH1 and H77s cell cultures."

23844083

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➶

reach

"In the present study, we demonstrate that an anthrapyrazole SP600125, a reversible ATP-competitive inhibitor of JNK inhibits proliferation of human HMC-1 showed constitutive activation of JNK and c-Jun, and the inhibitory effect of SP600125 on cell proliferation was associated with cell cycle arrest at the G1 phase and apoptosis accompanied by the cleavage of caspase-3 and PARP."

16923120

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➶

reach

"The JNK activity specific inhibitor, SP600125, and siRNA directed against JNK were used to block JNK and c-Jun pathway."

21943220

---

➶

medscan

"As expected, SP600125 prevented the phosphorylation of JNK, reduced the phosphorylation of c-Jun ( ) and suppressed by 50% Arsenic trioxide/ethacrynic acid-induced apoptosis ( )."

23082001

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➶

reach

"The application of JNK inhibitor, SP600125, blocked this increase in phospho-c-Jun, as well as c-Jun activity produced by mustard oil stimulation."

18822271

---

➶

reach

"SP600125 and TAM67 specifically inhibited JNK and c-Jun signaling as neither agent altered ERK1/2 phosphorylation (XREF_FIG)."

22644775

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➶

reach

"Interestingly, the addition of LY294002, SP600125 and PD98059 prevented the fibroin stimulation of c-Jun (XREF_FIG)."

22860103

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➶

medscan

"Inhibition of JNK/c-jun pathway with its inhibitor SP600125 reversed the phosphorylation of c-jun and the activation of caspase-3 induced by co-treatment of HuH-7 cells with melatonin and sorafenib in a dose-dependent manner."

28178378

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➶

reach

"Furthermore, MEKK2 immunoprecipitates activated c-Jun in an IL-1 dependent manner and this activity was inhibited by the selective JNK inhibitor SP600125."

14734742

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➶

reach

"Notably, to investigate whether the JNK and c-jun pathway participated in mediating the protective functions of 14,15-EET in OGD induced injury of CSMC, SP600125 was used to block the JNK and c-jun pathway."

29081082

---

➶

medscan

"Meanwhile, expression of c-Jun was lowered by SP600125, probably because phosphorylation of c-Jun is also required for maintaining its stability ."

22860098

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➶

reach

"SP600125 inhibited interleukin-1beta-induced JNK activity and activator protein-1 activation, but it did not affect the activation of extracellular regulated kinase, p38 mitogen activated protein kinase, and nuclear factor-kappaB."

15056726

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➶

medscan

"Both a JNK inhibitor (SP600125) and a ROCK inhibitor (Y27632) reduced G12-induced JNK and c-Jun activation, and markedly inhibited G12-induced cellular invasion."

27084452

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➶

sparser

"In contrast, inhibition of c-Jun NH(2)-terminal kinase (JNK) by SP600125 significantly enhanced apoptosis."

18392682

Lipopolysaccharide affects IFNB1

| 1 35

Lipopolysaccharide inhibits IFNB1. 36 / 36

| 1 35

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➶

reach

"Consistent with previous reports, LPS induced IFN-beta mRNA and protein (XREF_FIG) were not significantly decreased by MyD88 deficiency, whereas levels of TNF-alpha were dramatically inhibited in the MyD88 -/- macrophages (XREF_FIG)."

17562815

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➶

reach

"In accordance to the lack of LPS induced IFN-beta expression addition of a IFN-beta neutralizing antibody did not inhibit the LPS caused apoptosis (XREF_SUPPLEMENTARY)."

26863029

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➶

reach

"Indeed, Ifnb induction was slower, but more stable, in cells treated with P25 and LPS compared to free LPS."

28824614

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➶

reach

"It has been proposed that ERK activation is associated with suppression of LPS induced Ifnb and Il12b expression because it is necessary for induction of c-Fos, an inhibitor of both Ifnb and Il12b XREF_BIBR."

22427889

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➶

reach

"Therefore, we investigated whether HO-1 was involved in gAcrp mediated decrease in TLR4 expression and reduction in LPS stimulated IFN-beta and CXCL10."

20861358

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➶

reach

"In contrast to the BMDMs expressing an E3 ligase defective Peli1 mutant [XREF_BIBR], the Peli1-KO BMDMs did not show significant reduction in LPS stimulated IFN-beta induction."

26131354

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➶

reach

"CaMK inhibitor, STO609 inhibits LPS induced IFN-beta production."

23091438

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➶

reach

"On the other hand, the JAK-1 inhibitor marginally inhibited TNFalpha, LPS, IL-1beta, or Poly (I : C) induced induction of CCRL2, but almost completely blocked IFNgamma- or IFNbeta- dependent CCRL2 induction (XREF_FIG)."

22696441

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➶

reach

"Our results showed that IL-6, IFN-beta, and IFN-gamma secretion from KCs was significantly increased after LPS stimulation and significantly inhibited by urantide pre-treatment of the LPS stimulated KCs."

27448985

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➶

reach

"LPS induced IFNbeta synthesis was also attenuated in monocytic CD11b + cells from D138N RIPK1 kinase-inactive mice (D138N RIPK1 or Ripk1 D138N and D138N) (XREF_FIG)."

28461567

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➶

reach

"Calyculin A added 1.5 h after LPS treatment greatly reduced accumulation of IP-10, IRF-1, and TNFR-2 mRNA, but not TNF-alpha, IL-1 beta, and IFN-beta mRNA."

7636205

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➶

reach

"This differential effect involves theFasadaptor FADDbecausewhilst LPS induced IL-6production increasedin FADD -/- murine embryonic fibroblasts, LPS induced IFNbeta production was significantly reduced in these cells."

30536547

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➶

reach

"Underlying this protective effect is the ability of suppressive ODN to bind to and prevent the phosphorylation of STAT1 and STAT4, thereby blocking the signaling cascade mediated by LPS induced IFN-beta and IL-12."

15814679

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➶

reach

"Serum IFN-beta levels from PP2ACalpha-knockout mice treated with LPS were also greater than those in controls."

27872207

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➶

reach

"This basal IRF-7 protein was completely abolished in either Ifnar1 -/- or Stat1 -/- macrophages, which corresponded with the loss of LPS stimulated IFN-beta induction in these macrophages."

32373120

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➶

reach

"These results suggested that 2-AP inhibited LPS induced IFN-beta production by preventing Toll/IL -1 receptor domain containing adaptor inducing IFN-beta (TRIF)-dependent signaling rather than myeloid differentiation factor (MyD) 88 dependent signaling, resulting in the inhibition of NO production."

15611612

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➶

reach

"CaMK inhibitor, STO609, treatment inhibits LPS induced IFN-beta production, which is correlated with the phosphorylation of interferon regulatory factor 3 (IRF3)."

23091438

---

➶

reach

"Mechanism of inhibition of lipopolysaccharide induced interferon-beta production by 2-aminopurine."

22750230

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➶

reach

"It is also possible that the action of KC on STAT1 activation might be linked to the suppression of LPS induced IFN-beta, as IFN-beta is a principle STAT1 activating cytokine [XREF_BIBR]."

32290603

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➶

reach

"In contrast to the suggestion that p50 is responsible for Nfkb1 mediated inhibition of Ifnb, we have proposed that the ability of the C-terminal region of p105 to facilitate ERK activation is responsible for inhibition of LPS induced Ifnb expression XREF_BIBR."

22427889

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➶

reach

"LPS-induced IFN-b1 and CCL5/RANTES expression was also impaired in DDX3-knockdown HEK293 cells (Fig. 5A , lanes 9-10)."

26454002

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➶

reach

"One notable observation is that treatment of RAW 264.7 cells with bilirubin results in a marked reduction in LPS stimulated interferon-beta production, in the absence of an effect on cellular IL-6 release."

26163808

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➶

eidos

"EcN chassis itself and LPS induced low levels of IFNbeta1 expression in a TLR4-dependent but STING-independent manner ( Fig. 3a and Supplementary Fig. 3a ) , suggesting that TLR4 activation may play a minor role in type I IFN induction in response to SYNB1891 ."

32483165

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➶

reach

"Loss of TRAF3 severely compromised LPS driven IFN-beta induction irrespective of prior TLR2 priming (XREF_FIG, left panel)."

23853595

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➶

reach

"This inhibition was, in part, attributable to impaired LPS stimulated secretion of interferon-beta, an autocrine co-factor for NO production."

10733102

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➶

reach

"GSK3 inhibition also promotes LPS stimulated IFNbeta production via its ability to regulate c-Jun activity [XREF_BIBR]."

19836308

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➶

reach

"Artemisinin inhibits lipopolysaccharide induced interferon-beta production in RAW 264.7 cells : implications on signal transducer and activator of transcription-1 signaling and nitric oxide production."

23041519

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➶

reach

"LPS induced IFN-beta and IRF-1 gene expression were markedly suppressed by KE-758."

11409114

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➶

reach

"BPI suppressed LPS mediated IFN-beta promoter activation as was in NF-kappaB activation."

17239348

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➶

reach

"The decrease in LPS induced IFN-beta in the absence of Tpg was not statistically significant."

20660350

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➶

reach

"It has been demonstrated that HDAC3 deficient murine macrophages lack the ability to express inflammatory genes after LPS (lipopolysaccharide) stimulation, which is attributable to a secondary effect by the loss of LPS induced IFN-beta (interferone-beta) expression [XREF_BIBR]."

25793379

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➶

reach

"Consistent with this, we have found that the TLR4 ligand LPS is a poor inducer of IRF3 activation compared to virus infection, and that LPS induced IFN-beta is severely impaired in IKKbeta -/- MEFs."

20610653

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➶

reach

"When HO-1 expression was knocked-down, the anti-inflammatory effects of gAcrp on LPS stimulated IFN-beta and CXCL10 were attenuated (XREF_FIG)."

20861358

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➶

reach

"When studied after 24h of exposure, Ifnb mRNA levels markedly decreased in cells treated with free LPS, the mixture of LPS and NP, or the undiluted supernatant but, conversely, increased in cells incubated with the P25 and LPS fraction."

28824614

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➶

reach

"Unexpectedly, p204 deficiency led to significant defect in extracellular LPS signaling in macrophages, as demonstrated by dramatic reductions of LPS mediated IFN-beta and pro inflammatory cytokines."

29472103

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➶

reach

"In contrast, the ectopic expression of a constitutively active GSK3-beta (S9A) mutant severely attenuated the production of IFN-beta by LPS stimulated macrophages, as compared with empty vector transfected cells stimulated with LPS (XREF_FIG)."

18981097

Lipopolysaccharide affects NFKB1

| 31

Lipopolysaccharide inhibits NFKB1. 31 / 31

| 31

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➶

reach

"MicroRNA-322 inhibits inflammatory cytokine expression and promotes cell proliferation in LPS stimulated murine macrophages by targeting NF-kappaB1 (p50)."

27986864

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➶

reach

"Since both IFNgamma and LPS are known to activate NFkB, we determined whether LPS induced activation of NFkB is suppressed by netrin-1 in a macrophage cell line."

23447066

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➶

reach

"We observed significantly diminished LPS induced NF-kappaB p50 and p65 dimer translocation in the cells pretreated with 10mM metformin."

29147073

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➶

reach

"In LSEC, pre-treatment with BMP-9 reduced the LPS mediated activation of the NfkB pathway, whereas in macrophages, LPS partially inhibited the BMP-9 and Smad-1 signaling cascade."

32143367

---

➶

reach

"PGE 2 suppresses LPS induced degradation of p105."

19531803

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➶

reach

"PD-1 blockade increased the expression of (64 of 84 genes,> 2-fold increase) the majority of NFkB target genes in DCs and this effect was higher than the up regulation of NFkB target genes observed in the DCs treated with LPS, the latter of which is consistent with prior findings that LPS induced activation of cytokine gene expression is suppressed in TIDCs as compared to bone marrow derived DCs (XREF_FIG)."

26567141

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➶

reach

"Importantly, the exposure of IEC-6 cells to Celastrol resulted not only in a marked increase in cytoplasmic Hsp70 expression (red staining in XREF_FIG) but also to a significant reduction in the extent of TLR4 signaling, as measured by a reduction in the extent of LPS induced apoptosis (XREF_FIG), a reduction in the extent of LPS induced NFkB translocation (XREF_FIG), and a significant reduction in the extent of LPS induced IL-6 expression (XREF_FIG)."

22461698

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➶

reach

"In the present study, an extract from stem bark of Cinnamomum cassia Blume (Lauraceae) was discovered to have an inhibitory effect on LPS induced NF-KB transcriptional activity, which was determined using macrophages RAW 264.7 transfected stably with an alkaline phosphatase reporter construct containing four copies of the NF-KB binding KB sequence."

15503352

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➶

reach

"In mutant pre-B cells lacking IKKgamma, processing was unaffected, but LPS induced p105 degradation was abolished."

11158290

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➶

reach

"(B) InhIbItIOn of LPS induced NF-KB actIvatIOn by herbImycin A. C6 cells were pretreated for 12 h with herbimycIn A at the indicated concentratIOns followed by InCUbatIOn with 10, ug/ml LPS for I h. Then, nuclear extracts were prepared and analyzed by EMSA within 15 min reaching maximal levels within 60 min following exposure to LPS (data not shown)."

7556623

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➶

reach

"Baer et al. (1998) reported that LPS stimulation in macrophages promotes hyper-induction of p50 and TNFalpha gene repression."

17693123

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➶

reach

"LPS pretreatment completely blocked the nuclear localization of p50 induced by I/R injury, which can be reversed by knockdown of miR-146a."

27250735

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➶

reach

"Whereas in the presence of exogenously applied cell-permeable cGMP the IRAK3 mutant was able to retain its function by suppressing lipopolysaccharide induced NFkB activity."

31664109

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➶

reach

"MicroRNA-322 inhibits inflammatory cytokine expression and promotes cell proliferation in LPS stimulated murine macrophages by targeting NF-kappaB1 (p50)."

27986864

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➶

reach

"Reduced cell division and increased apoptosis of LPS stimulated nfkb1 -/- B cells was also shown not to be influenced by the presence of normal cells (Grumont, R.J., results not shown)."

9480976

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➶

reach

"The obtained results suggest that SC and SG oils exert the anti-inflammatory effects in LPS stimulated RAW 264.7 cells by suppressing NF-KB activation."

30549613

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➶

reach

"Our findings indicate miR-150 predicts survival in patients with sepsis and inhibits LPS induced inflammatory factors and apoptosis by targeting NF-kappaB1 in human umbilical vein endothelial cells."

29689269

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➶

reach

"P53 inhibition in CAIA and LPS treated PARK2 KO mice increased p50 and p65 nuclear localization and NF-kappaB activation."

28395174

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➶

reach

"The fact that lithium potently potentiated and greatly prolonged LPS stimulated p105 degradation suggests the existence of additional mechanisms."

19159680

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➶

reach

"MiR-150 predicts survival in patients with sepsis and inhibits LPS induced inflammatory factors and apoptosis by targeting NF-kappaB1 in human umbilical vein endothelial cells."

29689269

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➶

reach

"Using Western immunodetection of the NF kappa B1 p50 subunit, we also show that AraLAM and LPS stimulate the loss of the NF kappa B1 p105 precursor."

7729908

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➶

reach

"Recent studies demonstrate that the NF-kappaB1 precursor protein p105 functions as an inhibitor of Tpl2 and that the LPS stimulated Tpl2 activation requires p105 degradation."

16448710

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➶

reach

"Our results showed that LPS treatment caused the decrease of p65 and p50 in the cytoplasm and increase in nucleus, and this effect can be reversed by the pretreatment with WEL in a dose dependent manner."

24176090

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➶

reach

"Inhibition of the LPS induced NF-KB binding activity in nuclear extract of splenocytes by AAF."

8625282

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➶

reach

"Recently Oliver et al., [XREF_BIBR] have shown in 3T3-L1 adipocytes and in macrophages that DHA has greater anti-inflammatory effect compared to EPA by attenuating the LPS induced NFkB activation and TNF-alpha secretion."

23259689

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➶

reach

"Genes associated with pathways involved in fatty acid metabolism, LPS and IL-1-mediated inhibition of RXR function, NFkB signaling pathway and oxidative stress were highly impacted by SLD and LPS cotreatment."

20371263

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➶

reach

"LPS stimulated p105 degradation is mediated through phosphorylation of p105 by IKKbeta [XREF_BIBR, XREF_BIBR]."

19159680

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➶

reach

"However, MyD88 dependent activation of NFkB can also be induced by TAK1 independent pathways, as reported in TAK1 deficient murine embryonic fibroblasts, where incomplete suppression of IL1R or LPS induced NFkB activation was observed [XREF_BIBR]."

24009751

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➶

reach

"This was associated with a reduction of LPS-induced NF-KB binding activity."

| PMC

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➶

reach

"Furthermore, inhibition of cytokine production by 17 beta-estradiol was associated with a decreased LPS induced NFkB binding activity."

9266010

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➶

reach

"The addition of LPS (100 ng/mL, 15 min) significantly increased and decreased the nuclear content of p50 and RelA and p50 and p50, respectively (XREF_FIG)."

25184316

Lipopolysaccharide affects CASP1

| 1 1 1 28

Lipopolysaccharide inhibits CASP1. 31 / 31

| 1 1 1 28

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reach

"Scotton et al. [XREF_BIBR] demonstrated that stimulation of human monocytes with IL-13 (M2 polarization) is associated with downregulation of caspase-1 expression and a reduction in LPS induced caspase 1 activity, with resulting reduced cleavage of pro-IL-1beta and diminished secretion of LPS induced IL-1beta."

22281427

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reach

"In contrast to glyburide, SB203580 or knockdown of p38alpha MAPK significantly attenuated LPS induced decrease in LC3-II while reducing LPS induced activation of caspase-1 and increase of IL-1beta and IL-18 (XREF_FIG and S5, F and G)."

29196462

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➶

reach

"BHB also counteracted the LPS and ATP promoted cell migration by suppressing the activation of caspase-1 and the maturation of IL-1beta."

30218403

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➶

reach

"In the presence of latrunculin-b or colchicine, LPS induced caspase-1 activation and IL-18 production were reduced, suggesting a direct role of a dysfunctional actin cytoskeleton during inflammasome activation in Wdr1 mutant cells (XREF_FIG)."

26008898

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➶

reach

"Our present study demonstrated that KM inhibited LPS and ATP induced pyroptosis and the release of IL-1beta/18 in J774A.1 cells by inhibiting the activation of GSDMD and caspase-1 and the assembly of NLRP3 inflammasome."

30952097

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➶

reach

"In this study, there were no biologically significant changes in caspase activity following co-administration of TCDD and LPS; caspase-1 activity was reduced at day 14 in mice treated with TCDD and LPS compared to control mice treated with the same concentration of LPS."

12878042

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➶

isi

"While LPS increased inflammasome assembling and caspase-1 activation, AC treatment inhibited caspase-1 activation in D-HAEC (P <= 0.05)."

31935365

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➶

reach

"65 Thus, incubation of LPS stimulated macrophages with an IKK inhibitor, Bay11-7082, blocks NLRP3 induction and caspase 1 activation by ATP."

29158945

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➶

eidos

"Knockdown of MKK3 by siRNA in wild type BMDMs improved mitochondrial membrane potential , reduced LPS induced caspase-1 activation and attenuated cytokine secretion ."

25697779

---

➶

reach

"LPS inhibits lacrimal gland secretion by activating caspase 1, and IL-1beta activates the ERK pathway to inhibit lacrimal gland protein secretion and aqueous tear production."

18566460

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➶

reach

"The importance of the IL-1 system for high-dose, LPS induced septic shock is reflected by the LPS resistance of the IL-1beta converting enzyme deficient mice, known to have neither detectable serum levels of IL-1beta nor IL-1alpha upon LPS challenge."

20975042

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➶

reach

"The translocation of rCTB-YVAD is a prerequisite for the inhibition of LPS induced caspase-1 activation and subsequent IL-1beta secretion."

24884459

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➶

reach

"To further investigated whether CRD mediated inhibition of LPS induced caspase-1 activation and IL-1beta and IL18 expression was mediated by modulating the expression or function of NLRP3 inflammasome, we first examined the effect of LPS on NLRP3 expression with or without pretreatment with CRD."

28962083

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➶

reach

"Furthermore, chronic LPS stimulation induces similar reduction of caspase-1 activation and IL-1beta production in Ifnar2 -/- BMDMs (XREF_SUPPLEMENTARY)."

26412089

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➶

reach

"Moreover, in comparison to the infection with wt, chi12253 LPS strain did lead to a lower IL-1beta release from cells and decreased the level of caspase-1 cleavage into a mature form."

30429830

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➶

reach

"This protein synthesis is likely mediated by NF-kappaB, as pretreatment of cells with the proteasome inhibitor MG132, or the IkappaB kinase inhibitor Bay 11-7085 before LPS stimulation blocks the ability of LPS to potentiate the activation of caspase-1 by the P2X7R."

16301671

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➶

reach

"YopJ dependent caspase-1 activation and IL-1beta secretion were inhibited when BMDMs were treated with LPS prior to infection with Y. pseudotuberculosis XREF_BIBR or Y. pestis XREF_BIBR."

21533069

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➶

reach

"In conclusion, we suggest that CYT and quercetin decrease LPS induced inflammatory cytokine production by inhibiting NF-kappaB and caspase-1 activation."

21108840

---

➶

medscan

"Lipopolysaccharide, IL-1α, and TNFα dose-dependently increased MMP-3, MMP-9, and MMP-13 activity in cultured chondrocytes and in NLRP3(-/-) chondrocytes, and this effect was not changed by inhibiting caspase 1 or IL-1β."

22933232

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➶

reach

"Interestingly, prolonged LPS stimulation reduced caspase-1 processing in a time dependent fashion, and caspase-1 maturation was dramatically reduced in lysates of ATP treated BMDMs that had been stimulated with LPS for 24h (XREF_FIG)."

26412089

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➶

reach

"Meanwhile, suppression of NOX2 derived iROS production blocked LPS elicited caspase-1 activation and IL-1beta maturation in IL-10 -/- microglia in vitro and in vivo."

31940754

---

➶

reach

"Keller et al. [XREF_BIBR] reported that although caspase-1 is not involved in IL1alpha maturation, the lipopolysaccharide stimulated release of IL1alpha is drastically reduced in caspase-1 -/- monocytes and keratinocytes."

24511556

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➶

reach

"LPS injection causes liver damage as indicated by elevated ALT and AST levels, and a significant upregulation of both hepatic mRNA and protein levels for all the inflammasome components including NALP3, and two cytokine targets of caspase-1, IL-1beta and IL-18."

26936883

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➶

reach

"Inhibitory effect of rCTB-YVAD on LPS induced caspase-1 activation and subsequent IL-1beta secretion in Caco-2 cells."

24884459

---

➶

reach

"Consistent with the previous findings [XREF_BIBR], we found that WT Listeria induced less caspase-1 processing and cell death in NLRP3-KO macrophages compared to WT macrophages (XREF_FIG), suggesting that NLPR3 is partially involved in caspase-1 activation after Listeria infection and that absence of LPS priming reduces but does not abrogate caspase-1 activation or cell death in these macrophages."

20490635

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➶

reach

"The results showed that pretreatment with Teuvincenone F and then LPS simulation blocked caspase-1 cleavage and IL-1beta production in a dose dependent manner in mouse peritoneal macrophages."

28878677

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➶

reach

"In three separate assay systems, LPS induced lethality, LPS and IL-4-induced IL-1beta cleavage, and LPS and IL-4-induced DNA fragmentation, heterozygotes showed a phenotype similar to the wt, arguing against a dominant negative effect.Pyrin inhibits caspase-1 and IL-1beta activation through interactions with ASC."

12667444

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➶

reach

"Our results show that LPS primed macrophages pre-incubated with the HSM extract causes decreased activation of caspase-1 in ATP treated macrophages."

23459183

---

➶

reach

"As shown in XREF_FIG, LPS induced caspase-1 activation was decreased by treatment of PA at a dose dependent manner, consistent with the result on IL-1beta production (XREF_FIG)."

23213315

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➶

reach

"The results showed that LPS induced caspase-1 activation was much lower in cells expressing ULK1/2A than ULK1-WT, and expression of phosphorylation mimicking ULK1 (ULK1/2E) alone could induce caspase-1 activation (XREF_FIG)."

29196462

---

➶

reach

"Western blot analysis indicates that LPS treatment induced degradation of caspase-1 precursor, which was inhibited by treatment CYT or quercetin."

21108840

Glyburide affects CASP1

| 2 28

Glyburide inhibits CASP1. 30 / 30

| 2 28

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➶

reach

"Inhibition of caspase-1 activation by glyburide was reversible because caspase-1 was activated if glyburide was removed from the culture medium before ATP addition."

19805629

---

➶

reach

"Glyburide reduced caspase-1 activity to levels not significantly different from the saline control."

27066297

---

➶

reach

"In a cyclophosphamide induced rat model of cystitis, glibenclamide treatment decreased caspase-1 activity along with levels of IL-1beta and IL-18 and subsequent bladder inflammation [XREF_BIBR]."

28740332

---

➶

reach

"Glyburide effectively blocked caspase-1 activation and IL-1beta secretion by these stimuli too (XREF_FIG)."

19805629

---

➶

medscan

"To complement these experiments, we analyzed whether glyburide prevented caspase-1 activation in macrophages lacking adenosine triphosphatase-binding cassette transporters or KATP channels."

19805629

---

➶

reach

"In this work, we found that glibenclamide could inhibit Nalp3 inflammasomes and Caspase-1 induced by LPS+ high glucose stimulation in cultured peritoneal macrophages, suggesting that the effects of glibenclamide on prevention of serum IL-1beta and TNF-alpha might be related to inhibiting Nalp3 inflammasomes and Caspase-1."

25077824

---

➶

reach

"For inhibitor experiments, glyburide (100 mumol/L) and Z-YVAD-FMK (2 mumol/L) were added 30 minutes before PM 10 exposure to inhibit the NLRP3 inflammasome 38 or caspase-1, respectively."

22227418

---

➶

reach

"In contrast to the related sulfonylurea glipizide, glyburide inhibited caspase-1 processing in a dose dependent fashion (XREF_FIG), and this prevented secretion of the caspase-1-dependent cytokines IL-1beta (XREF_FIG) and IL-18 (XREF_FIG)."

19805629

---

➶

reach

"Our results indicated that glibenclamide suppressed NLRP3, caspase-1, and IL-1beta in mice spinal cord in morphine tolerance."

29178967

---

➶

reach

"This enhancement of inflammasome activation by IAV in Ripk2 -/- BMDCs was dependent on NLRP3, as the NLRP3 specific inhibitor glyburide 32 significantly inhibited caspase-1 activation and IL-18 production (XREF_FIG)."

23525089

---

➶

reach

"To complement these experiments, we analyzed whether glyburide prevented caspase-1 activation in macrophages lacking ABC transporters or K ATP channels."

19805629

---

➶

reach

"Glyburide not only inhibited IL-1beta production and caspase-1 activation downstream of the P2X7 receptor, but was also effective against ATP-, nigericin- and IAPP induced inflammasome activation."

29515457

---

➶

reach

"Furthermore, we tested whether glibenclamide, a NLRP3 inflammasome inhibitor, can prevent the activation of both caspase-1 and caspase-3 induced by Tet-regulatable p210BCR-ABL expression in 32D/TetOff-p 210 cells."

30167087

---

➶

medscan

"Glyburide, which specifically inhibits NLPR3 inflammasome activation [ ], was used to inhibit NLRP3, and capase-1 inhibitor YVAD was used to inhibit caspase-1."

27250627

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➶

reach

"Furthermore, in in vitro studies, we found that glibenclamide inhibited caspase-1 activation and the maturation of IL-1beta induced by morphine and LPS in the presence of ATP."

29178967

---

➶

reach

"The western blot analysis showed that 1microM MCC950 and 200microM glyburide significantly inhibited the activation of caspase-1 in to the cleaved form caspase-1 p10."

29872077

---

➶

reach

"In agreement with this, glibenclamide (Gly), a potassium channel inhibitor, blocked caspase 1 activation and IL-1beta release induced by UCN as well as IL-1beta release induced by Nd 2 O 3 and Y 2 O 3 nanocrystals."

27632706

---

➶

reach

"Previously, we demonstrated that glyburide can block the activation of brain caspase-1 triggered by adenosine which is a key biologic in hypoxia induced anterograde amnesia."

27563288

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➶

reach

"Glyburide had no effect on NLRP3, caspase-1 and IL-1beta expression as compared with the control group, while the NLRP3, caspase-1 and IL-1beta were decreased by (20.49 +/-7.6)% (t = 2.862, P < 0.01), (32.94 +/-3.44)% (t = 4.154, P < 0.001) and (24.67 +/-5.29)% (t = 2.335, P < 0.05) in the PDGF+ glyburide group, respectively, as compared with the PDGF group."

28592027

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➶

reach

"To determine whether caspase-1 activation is impaired by glyburide, LPS primed bone marrow derived macrophages (BMDMs) were incubated with glyburide for 15 min before ATP was added for another 30 min."

19805629

---

➶

reach

"In agreement with the effects seen previously on IL-1beta secretion and caspase-1 activation glyburide and parthenolide did not inhibit AIM2 dependent ASC oligomerisation."

22216309

---

➶

reach

"Concurrently, glyburide inhibited caspase-1 activation by LPS+DOTAP (XREF_FIG), a stimulus that engages the Cryopyrin inflammasome independently of the P2X 7 receptor and pannexin-1."

19805629

---

➶

reach

"Additionally, glibenclamide inhibited NLRP3 and caspase-1 expression [XREF_BIBR]."

28740332

---

➶

reach

"In addition, glyburide, an anti-diabetic drug that inhibits caspase-1 activation and IL-1beta secretion, may also serve as an effective inhibitor of NLRP3 formation following stress induced depression."

24850149

---

➶

reach

"Both caspase-1 activity in the urothelia and IL-1beta in the urine was prevented or attenuated by glyburide."

27066297

---

➶

reach

"These results demonstrate that the Cryopyrin inflammasome is essential for LPS+ATP-induced macrophage death and that glyburide inhibits LPS+ATP-induced caspase-1 activation, IL-1beta secretion, and macrophage death."

19805629

---

➶

reach

"One of the few studies in the murine model of cyclophosphamide (CP) induced cystitis, glyburide suggested to suppress caspase-1 with reduction in the release of IL-1beta; whereas NLRP3 inhibition blocks bladder dysfunction in CP model."

27994587

---

➶

reach

"Glyburide (100 mumol/L) and Z-YVAD-FMK (2 mumol/L) did not completely inhibit caspase-1 cleavage, which is consistent with the literature."

22227418

---

➶

reach

"Glyburide inhibits LPS+ATP-induced caspase-1 activation, IL-1beta secretion, and macrophage death."

19805629

---

➶

reach

"Glibenclamide did not prevent the activation of both caspase-1 and caspase-3 (XREF_SUPPLEMENTARY)."

30167087

Curcumin affects NLRP3

| 30

Curcumin inhibits NLRP3. 30 / 30

| 30

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➶

reach

"Curcumin Reduces Neuronal Loss and Inhibits the NLRP3 Inflammasome Activation in an Epileptic Rat Model."

30062967

---

➶

reach

"Moreover, Bay 11-7082 (a NF-kappaB-specific inhibitor) markedly reduced NLRP3 inflammasome activation, which was dramatically attenuated by curcumin treatment."

27777559

---

➶

reach

"Our main finding indicates that the addition of curcumin concomitantly with LPS caused the greatest decrease in NLRP3 S glutathionylation and a respective increase in caspase-1 S glutathionylation, which appears to favor protein protein interactions in the NLRP3 complex."

28669709

---

➶

reach

"Curcumin suppresses NLRP3 inflammasome activation and protects against LPS induced septic shock."

26250869

---

➶

reach

"Curcumin Attenuates the Activation of the NLRP3 Inflammasome."

27777559

---

➶

reach

"Therefore, we hypothesized that curcumin inhibited the activation of the NLRP3 inflammasome via the mechanism of P2X7R."

27777559

---

➶

reach

"Given the effect of curcumin on the expression of NLRP3 inflammasome and regulation of TLR4/MyD88/NF-kappaB and P2X7R, we concluded that curcumin reduced NLRP3 inflammasome, cleaved caspase-1 induction, and consequently reduced IL-1beta secretion through TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA induced macrophages; the schematic model is shown in Figure XREF_FIG."

27777559

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➶

reach

"NLRP3 inflammasome activation was dramatically inhibited by curcumin in DSS stimulated macrophages, as evidenced by decreased IL-1beta secretion, less caspase-1 activation and ASC specks."

30396035

---

➶

reach

"This is because curcumin has been shown to reduce NLRP3 inflammasome activation and IL-1beta production in lipopolysaccharide induced septic shock [XREF_BIBR], and both IL-1beta (a proinflammatory cytokine) and NLRP3 inflammasomes have been shown to be involved in the development of DN [XREF_BIBR, XREF_BIBR]."

28194406

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➶

reach

"Curcumin treatment prevented ER stress and NLRP3 inflammasome activation in the hippocampus, indicating the potential molecular target for its action."

25791922

---

➶

reach

"Our data indicated that curcumin can inhibit the NLRP3 inflammasomes via (at least patially) decreasing P2X7R."

27777559

---

➶

reach

"As a possible molecular mechanism, they found that, in mice hippocampus, glutamate stimulation increased NLRP3 expression and the cleaved form of caspase-1 enzyme, while curcumin attenuated NLRP3 and cleaved caspase-1 expression."

27672241

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➶

reach

"Indeed previous reports suggest that curcumin can inhibit the NLRP3 inflammasome activation and subsequent release of mature IL-1beta both in J774A.1 cells, as well as murine peritoneal macrophages in in vivo experiments."

27777559

---

➶

reach

"Curcumin, as well as TUDCA, attenuated NLRP3 and cleaved caspase-1 expression (Figs. 6 A & B), and as expected, reduced IL-1beta secretion."

25791922

---

➶

reach

"Curcumin inhibited the NLRP3 inflammasome by preventing K + efflux and disturbing the downstream events, including the efficient spatial arrangement of mitochondria, ASC oligomerization, and speckle formation."

29549176

---

➶

reach

"Another study showed that curcumin inhibited TXNIP and NLRP3 inflammasome activation by suppressing endoplasmic reticulum stress and thereby protected neuronal cell survival from glutamate neurotoxicity after ischemic insult [XREF_BIBR]."

27652274

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➶

reach

"Curcumin, as well as allopurinol, notably up-regulated miR-200a expression, accordingly, down-regulated TXNIP and inhibited NLRP3 inflammasome activation in fructose fed rat livers and fructose exposed BRL-3A and HepG2 cells."

30248460

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➶

reach

"Our work showed that curcumin inhibited TXNIP and NLRP3 inflammasome activation by suppressing ER stress, and thereby protected neuronal cell survival from glutamate neurotoxicity.Brain ischemia induces extrasynaptic glutamate release (Soria et al., 2014)."

25791922

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➶

reach

"We found that NLRP3 expression and caspase-1 and IL-1beta cleavage were inhibited after curcumin treatment in HK-2 cells exposed to high glucose levels, showing that curcumin inhibits the activation of NLRP3 inflammasomes."

28194406

---

➶

reach

"These results demonstrated that curcumin inhibited NLRP3 inflammasome activation under ER stress conditions."

25791922

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➶

reach

"Curcumin potently inhibits the activation of NLRP3 inflammasome which may contribute to its anti-inflammatory activity."

26250869

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➶

reach

"As a result from suppression of ER stress associated TXNIP induction, curcumin inhibited NLRP3 and caspase-1 activation, and thereby reduced IL-1beta secretion."

25791922

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➶

reach

"Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-kappaB and P2X7R Signaling in PMA Induced Macrophages."

27777559

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➶

reach

"Conclusion : Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA induced macrophages."

27777559

---

➶

reach

"These results indicated that curcumin suppressed NLRP3 inflammasome activation and thus inhibited inflammatory response.In addition to evoked inflammation, NLRP3 inflammasome activation is responsible for apoptosis, in which mitochondrial malfunction plays a critical role."

25791922

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➶

reach

"Importantly, in vivo data show that curcumin attenuated IL-1beta secretion and prevented high-fat diet induced insulin resistance in wide-type C57BL/6 mice but not in Nlrp3 -deficient mice."

29549176

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➶

reach

"Curcumin also inhibited the stressed induced P2X7R and NLRP3 inflammasome axis activation, along with the reduced transformation of pro-IL-1beta to mature IL-1beta."

30551030

---

➶

reach

"To confirm whether curcumin inhibited NLRP3 inflammasome activation through P2X7R signaling cascade, the receptor was silenced."

27777559

---

➶

reach

"Curcumin suppressed the upregulation of NLRP3, caspase-1, pro-IL-1beta and IL-1beta proteins (XREF_FIG), the increased ratio of caspase-1 to procaspase-1 and IL-1beta to pro-IL-1beta (XREF_FIG), as well as the enhanced caspase-1 activity (XREF_SUPPLEMENTARY), but had no significant effect on procaspase-1 expression (XREF_FIG) in SHR derived VSMCs."

28981106

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➶

reach

"In addition, curcumin reduced NLRP3 inflammasome activation in lupus-prone mice."

30738291

Melatonin affects NLRP3

| 29

Melatonin inhibits NLRP3. 29 / 29

| 29

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➶

reach

"Moreover, oxidative stress and NLRP3 inflammasome activation in carotid arteries of smoking rats was also inhibited by melatonin."

31521245

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➶

reach

"Moreover, in the irradiated RAW 264.7 cells, melatonin blocked the NLRP3 inflammasome activation accompanied with the inhibition of the IL-1beta release and caspase-1 activity."

30755784

---

➶

reach

"Herein, we demonstrate that melatonin suppressed prolonged NLRP3 inflammasome activation in atherosclerotic lesions by reactive oxygen species (ROS) scavenging via mitophagy in macrophages."

30254716

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➶

reach

"In this study, melatonin was observed to inhibit ROS production, NLRP3 inflammasome activation and pyroptosis in CSE treated ECs."

31521245

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➶

reach

"In ox-LDL-treated macrophages, melatonin attenuated the NLRP3 inflammasome activation and the inflammatory factors secretion, while this protective effect was abolished by either Sirt3 silence or autophagy inhibitor 3-MA."

30254716

---

➶

reach

"Likewise, via SIRT1 stimulation, melatonin inhibits the NLRP3 inflammasome and IL- 1β generation."

| PMC

---

➶

reach

"We made the following observations : (1) treatment with melatonin upregulated mitophagy associated proteins (PINK1 and Parkin) and reduced mitochondrial damage and ROS generation after SAH; (2) administration of melatonin inhibited NLRP3 inflammasome activation after SAH and attenuated the inflammatory response; (3) melatonin treatment reduced neuronal cell death, brain edema and neurological dysfunction following SAH; and (4) pretreatment with 3-MA reversed the beneficial effect of melatonin on the inhibition of NLRP3 inflammasome activation."

28546552

---

➶

reach

"Melatonin inhibited NLRP3 inflammasome activation and attenuated pro inflammatory cytokine secretion after SAH."

28546552

---

➶

reach

"Furthermore, melatonin inhibited the NLRP3 inflammasome activation through the suppression of extracellular histone release [XREF_BIBR]."

32422305

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➶

reach

"We found that the NLRP3 inflammasome related genes were highly expressed in single microglia from morphine treated mice, while melatonin pretreatment significantly reversed the NLRP3 inflammasome activation induced by morphine (XREF_FIG H)."

32413745

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➶

reach

"Of note, we have revealed that radiation induced NLRP3 inflammasome activation was attenuated by melatonin exposure, while this effect of melatonin was markedly negated by repressing miR-30e levels with its inhibitor in macrophages."

30755784

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➶

reach

"They have extensively demonstrated that melatonin could inhibit the NLRP3 inflammasome pathway in radiation induced oral mucositis [XREF_BIBR] and cecal ligation induced sepsis [XREF_BIBR]."

30755784

---

➶

reach

"Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice."

32738376

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➶

reach

"* Melatonin : Melatonin has been shown to inhibit NFkB activation and NLRP3 inflammasome activation."

32229082

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➶

reach

"Melatonin also significantly reduced the oxidative stress and injury of lungs exposed to radiation through the suppression in the infiltration of neutrophils (CD11b+Ly6G+) and macrophages (CD11b+CD11c-), and the down-regulation of NLRP3 inflammasome in macrophages (accompanied with a reduction in the release of IL-1β and the activity of caspase-1 or CASP1), by the up-regulation of miR-30e levels [79]."

32422305

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➶

reach

"Since melatonin pretreatment also blocked NLRP3 inflammasome activation following LPS treatment (XREF_FIG I and J), it would be rewarding to test whether melatonin functioned in a more general mechanism than just blocking morphine induction, and whether it had a similar effect on alleviating the detrimental side effects of other opioid analgesics."

32413745

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➶

reach

"Additionally, the results showed that melatonin suppressed NLRP3 inflammasome activation by regulating Wnt and beta-catenin signaling, which was confirmed by the Wnt and beta-catenin inhibitor recombinant DKK1."

29804160

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➶

reach

"Melatonin gel prevents external radiation induced NLRP3 inflammasome pathway activation in small intestine epithelia."

28403142

---

➶

reach

"Melatonin also decreased NF-kappaB-dependent proinflammatory response and restored redox balance and mitochondrial homeostasis, thus inhibiting the NLRP3 inflammasome."

26045547

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➶

reach

"Moreover, exogenous melatonin pronouncedly ameliorated airway inflammation and decreased the activation of NLRP3 inflammasome."

31738882

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➶

reach

"It is well documented that melatonin prevents chronic obstructive pulmonary disease by attenuating NLRP3 inflammasome and IL-1β, responsible for the inflammation of airways during It was documented that exposure to nicotine in pregnant rats caused significant changes in the lungs of their offspring at a structural and biochemical level."

32422305

---

➶

reach

"Melatonin could diminish ROS and consequently inhibited the activation of NLRP3 inflammasome, suppressed the over-activated IL-1beta signaling, which finally attenuated the development of morphine analgesic tolerance (XREF_FIG)."

32413745

---

➶

reach

"Garcia et al. reported that melatonin inhibits NF-kappaB and NLRP3 activation by regulating the retinoic acid receptor related orphan receptor alpha pathway [XREF_BIBR]."

32377306

---

➶

reach

"Consequently, melatonin mediated upregulation of proteins associated with mitophagy inhibited NLRP3 inflammasome activation and significantly reduced pro inflammatory cytokine levels after SAH."

28546552

---

➶

reach

"How melatonin directly blocks activation of the NLRP3 inflammasome in ALI remains unclear."

26888116

---

➶

reach

"Furthermore, melatonin decreased NLRP3 inflammasome activation and the consequent IL-1 beta secretion within atherosclerotic lesions."

30254716

---

➶

reach

"Melatonin also attenuated NLRP3 inflammasome activation and pyroptosis, which was induced by LPS or obesity."

28398673

---

➶

reach

"Western blot analysis showed that the expressions of NLRP3 and ASC significantly increased following 15Gy irradiation, whereas melatonin treatment markedly attenuated the NLRP3 and ASC activations compared with those vehicle treated."

30755784

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➶

reach

"It is well documented that melatonin prevents chronic obstructive pulmonary disease by attenuating NLRP3 inflammasome and IL-1β, responsible for the inflammation of airways during this pathology."

32422305

Doramapimod affects MAPK14

1 28 |

Doramapimod inhibits MAPK14. 29 / 29

1 28 |

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No evidence text available

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26800309

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15975507

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17095218

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20663667

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18602262

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22749282

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22154891

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12086485

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20621496

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18183025

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22014550

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21888439

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23941661

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➶

tas

No evidence text available

12941343

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

23270382

---

➶

tas

No evidence text available

15711537

---

➶

tas

No evidence text available

17181176

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

14561086

---

➶

tas

No evidence text available

19356929

---

➶

tas

No evidence text available

18325768

---

➶

tas

No evidence text available

23937569

---

➶

signor

No evidence text available

Other

SB-202190 affects MAPK14

14 | 15

SB-202190 inhibits MAPK14. 29 / 29

14 | 15

---

➶

medscan

"Inhibition of p38(MAPK) signaling by SB202190 completely abrogated Lysophosphatidic acid-induced uPA secretion, while inhibition of the p42/44(MAPK) or PI3K pathways with PD98059 or wortmannin and LY294002, respectively, decreased but did not completely block uPA secretion."

17611702

---

➶

medscan

"Inhibition of p38 mitogen-activated protein kinase (by SB202190 and SB203580) or a dominant-negative mutant of Sema-3A receptor plexin-A1 reversed the inhibitory effects of VEGF in normal mesothelial cells, increasing cyclin D1 synthesis and cell growth."

14656993

---

➶

tas

No evidence text available

16509574

---

➶

tas

No evidence text available

---

➶

medscan

"Unlike SAPK2a and SAPK2b, SAPK4 and SAPK3 were not inhibited by the drugs SB 203580 and SB 202190."

9218798

---

➶

medscan

"Downstream signaling routes involve mitogen-activated protein kinase kinase (MEK)1/extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase, as Galectin-1 expression was prevented by U0126 and SB202190."

15663199

---

➶

tas

No evidence text available

10998351

---

➶

tas

No evidence text available

28280261

---

➶

medscan

"Inhibition of p38(MAPK) by SB202190 and p38(MAPK) small interfering RNA reduces bFGF-induced death in TC-32 cells, consistent with the hypothesis that activation of p38(MAPK) is essential for induction of death by bFGF."

15310753

---

➶

medscan

"Selective inhibition of p38 mitogen-activated protein kinase by SB203850 or SB202190 also blocked phenylephrine-induced scattering, whereas treatment of TFG2 cells with the PI3 kinase inhibitors LY294002 or wortmannin did not inhibit phenylephrine-induced scattering."

10912793

---

➶

medscan

"heat shock protein-27-mediated inhibition of monocyte-->immature DC differentiation was reversed by p38alpha & beta inhibitor (SB202190) addition or TLR4 receptor modulation."

17823891

---

➶

tas

No evidence text available

19591487

---

➶

tas

No evidence text available

22014755

---

➶

medscan

"Interestingly, inhibition of p38 mitogen-activated protein kinase pathway by SB202190 impeded guanosine 5'-triphosphate-mediated caspases activation and differentiation in K562 cells, suggesting that p38 mitogen-activated protein kinase may act upstream of caspases in our system."

17543571

---

➶

tas

No evidence text available

17923491

---

➶

medscan

"Cell death induced by high amounts of SNAP/sodium nitroprusside or by strong overexpression of iNOS involved activation of p38MAP-kinase, which was counteracted by the p38MAP-kinase inhibitor SB202190."

19130609

---

➶

medscan

"The inhibition of p38 mitogen-activated protein kinase by SB202190 reduced Tristetraprolin expression."

23030431

---

➶

tas

No evidence text available

28195723

---

➶

tas

No evidence text available

15711537

---

➶

tas

No evidence text available

11549467

---

➶

tas

No evidence text available

24878193

---

➶

tas

No evidence text available

24930833

---

➶

tas

No evidence text available

18077363

---

➶

medscan

"Finally, we studied HIF1alpha and FoxO3A expressions and signaling pathways to evaluate their role in SB202190-induced effects. p38alpha blockade induces the formation of intracellular autophagic vacuoles and reduces growth and viability of ovarian cancer cells."

20169663

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➶

medscan

"The antiapoptotic effect of CO in endothelial cells was abrogated when activation of the p38alpha and p38beta MAPKs was inhibited by the pyridinyl imidazole SB202190."

16849502

---

➶

medscan

"The results demonstrated that Pokemon overexpression significantly promoted the migration ( ) and invasion ( ) of HepG2 cells while silencing by si-RNA reduced the migration ( ) and invasion ( ), and consistent results were obtained with using BEL7404 cells with silenced Pokemon ( ). p38 inhibitor SB202190 specifically inhibits the activity of p38β and p38α [ ]."

23807508

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➶

medscan

"In contrast, inhibition of the p38mitogen-activated protein kinase pathway by SB202190 potentiated differentiation and the up-regulation of pRb and C/EBPbeta."

14729647

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➶

medscan

"We found that Pokemon had a promoting effect on p38β expression and its downstream, phosphorylated ATF2, but no significant effect on p38α ( ). p38 inhibitor SB202190, which specifically inhibits the activity of p38β and p38α, efficiently attenuates the levels of p38β and phosphorylated ATF2 triggered by Pokemon, proving the role of p38α or p38β in this signaling."

23807508

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➶

tas

No evidence text available

18183025

Nitric oxide affects CASP1

| 1 26

Nitric oxide inhibits CASP1. 27 / 27

| 1 26

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➶

reach

"Under these conditions, NO also inhibited IL-1beta secretion and caspase-1 activation but did not affect IL-6 or TNF-alpha secretion (XREF_FIG and XREF_FIG and XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY), and NLRP3 or ASC expression (XREF_FIG)."

23318584

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➶

reach

"Recently, it was shown that nitric oxide (NO) can suppress directly the action of caspase-1, resulting in the prevention of IL-1beta and IL-18 secretion [33]."

11312119

---

➶

reach

"Nitric oxide suppresses NLRP3 inflammasome mediated IL-1beta secretion and caspase-1 activation in mouse macrophages."

23318584

---

➶

reach

"Although NO can inhibit caspase-1 activity by direct modification XREF_BIBR, XREF_BIBR, we asked whether the inhibitory effect of NO on ASC pyroptosome formation was caspase-1 independent."

23318584

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➶

reach

"It was previously shown that inflammasome activation was inversely correlated to iNOS expression, and that NO inhibited IL-1beta production and caspase-1 activation."

26172313

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➶

sparser

"Indeed, Dimmeler et al. [16] have recently shown that caspase-1 and caspase-3 are inhibited by nitric oxide, and they provide evidence for nitrosylation of the active site thiol group."

9323034

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➶

reach

"In addition, increased expression of NOS2 in PDE3B -/- adipose tissue may contribute to increased NO (XREF_FIG), which inhibits caspase-1, preventing release of IL1beta and IL18 XREF_BIBR, and inhibit NLRP3 inflammasome activation XREF_BIBR."

27321128

---

➶

reach

"It has been reported that NO can inhibit caspase-1 activity by direct modification XREF_BIBR, XREF_BIBR."

23318584

---

➶

reach

"Since NO inhibits caspase 1 activity, this provides a potential feedback loop, whereby IL-18 may regulate its own cleavage [22,26]."

12527218

---

➶

reach

"Since NO inhibits caspase 1 activity, this provides a potential feedback loop whereby IL-18 may regulate its own cleavage."

10871869

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➶

reach

"Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1beta-converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32-like Proteases."

9034139

---

➶

reach

"These data indicate that the inhibitory effect of NO on NLRP3 mediated ASC pyroptosome formation is completely independent of caspase-1."

23318584

---

➶

reach

"The findings reported above suggested that exogenous NO donors inhibited NLRP3 inflammasome mediated IL-1beta secretion and caspase-1 activation."

23318584

---

➶

reach

"Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases."

9034139

---

➶

reach

"Although the reason for such a decrease in IL-18 levels in patients with CM was not clear from the present study, it is possible that nitric oxide (NO), if produced in cases with CM, may suppress the action of caspase-1 that regulates IL-18 production by cleaving proIL-18 to induce mature IL-18, thereby inducing reduction of IL-18 levels (Kim et al., 1998)."

14744554

---

➶

reach

"Endogenous NO produced by iNOS negatively regulates NLRP3 inflammasome mediated IL-1beta secretion and caspase-1 activation."

23318584

---

➶

reach

"Thus, the downregulation of caspase-1 by NO may be important for the negative regulation of IL-18 and -1 beta.Recently, caspase-1-independent secretion of IL-1beta was demonstrated [34]."

11312119

---

➶

reach

"Similar to what was observed above, NO inhibited IL-1beta secretion and caspase-1 activation under different TLR stimulation conditions (XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY)."

23318584

---

➶

reach

"The NO donor S-nitroso-N-acetyl-DL-penicillamine inhibited caspase-1 activity in cells as well as the activity of purified recombinant caspase-1 and also prevented the cleavage of pro-IL-1beta and pro IGIF by recombinant caspase-1."

9780184

---

➶

reach

"In this study, we found that NO not only inhibits NLRP3 inflammasome mediated IL-1beta secretion and caspase-1 activation, but also inhibits NLRC4- and AIM-2-mediated IL-1beta secretion and caspase-1 activation (XREF_SUPPLEMENTARY), but to a much less extent (3-fold decrease for NLRC4 and AIM-2, 40-fold decrease for NLRP3)."

23318584

---

➶

reach

"These data provide clear evidence that NO suppresses NLRP3 inflammasome mediated IL-1beta secretion and caspase-1 activation in mouse macrophages."

23318584

---

➶

reach

"Recently, it was shown that nitric oxide (NO) can suppress directly the action of caspase-1, resulting in the prevention of IL-1beta and IL-18 secretion [33]."

11312119

---

➶

reach

"The inhibition of caspase-1 by NO was reversible by the addition of DTT, which is consistent with S nitrosylation as the mechanism of caspase-1 inhibition."

9780184

---

➶

reach

"In this case, NO also suppressed NLRP3 inflammasome mediated caspase-1 activation (XREF_SUPPLEMENTARY)."

23318584

---

➶

reach

"A previous study showed that NO could suppress caspase-1 in murine macrophages, resulting in decreased IL-1beta [XREF_BIBR]."

32454788

---

➶

reach

"The blockade of CD36 had no effect on PrP 106-126 -stimulated NF-kappaB activation and TNF-alpha protein release, abrogated the PrP 106-126 -induced iNOS stimulation, downregulated IL-1beta and IL-6 expression at both mRNA and protein levels as well as TNF-alpha mRNA expression, decreased NO production and Fyn phosphorylation, reduced caspase-1 cleavage induced by moderate PrP 106-126 -treatment, but had no effect on caspase-1 activation after treatment with a high concentration of PrP 106-126."

22292032

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➶

reach

"Although the reason for such a decrease in IL-18 levels in patients with CM was not clear from the present study, it is possible that nitric oxide (NO), if produced in cases with CM, may suppress the action of caspase-1 that regulates IL-18 production by cleaving proIL-18 to induce mature IL-18, thereby inducing reduction of IL-18 levels (Kim et al., 1998)."

14744554

Baicalin affects NLRP3

| 27

Baicalin inhibits NLRP3. 27 / 27

| 27

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➶

reach

"Therefore, apart from its inhibitory effects on NLRP3 transcription as revealed by previous studies, baicalin can also inhibit NLRP3 inflammasome activation in macrophages upon ATP or nigericin triggering."

29163487

---

➶

reach

"Baicalin Inhibits NLRP3 Inflammasome Activation in BMDMs."

29163487

---

➶

reach

"In this study, we found that baicalin markedly inhibited NLRP3 inflammasome activation in LPS primed macrophages upon ATP or nigericin triggering, thereby blocking the activation of caspase-1 and the release of mature IL-1beta and HMGB1."

29163487

---

➶

reach

"Although baicalin inhibited the activation of NLRP3 inflammasome, the effects of baicalin on the function of PMNP needs further investigation."

27502767

---

➶

reach

"On the contrary, baicalin treatment could either inhibit the formation of ASC specks in immunofluorescence or decrease the NLRP3, ASC, pro-caspase-1 in a dose dependent manner."

29163427

---

➶

reach

"In light of previous findings that the PKA negatively regulates NLRP3 activation and that baicalin may increase the PKA activity, we next explored whether baicalin suppressed the NLRP3 inflammasome activation by upregulating PKA signaling in macrophages."

29163487

---

➶

reach

"Baicalin Mediated Inhibition of NLRP3 Inflammasome Activation and IL-1beta Release Is Reversed by the PKA Pathway Inhibitors."

29163487

---

➶

reach

"Taken together, in our study, we demonstrate for the first time that baicalin has an anti-inflammatory activity, and inhibits the NF-kappaB signaling pathway and NLRP3 inflammasome activation in PMNP when infected with H. parasuis."

27502767

---

➶

reach

"Together, these data further confirmed that baicalin treatment inhibited NLRP3 inflammasome activation through blocking ASC recruitment into the NLRP3 inflammasome."

29163487

---

➶

reach

"Taken together, these results indicated that baicalin inhibited NLRP3 inflammasome activation in macrophages upon ATP or nigericin stimulation."

29163487

---

➶

reach

"Furthermore, blocking cAMP formation by inhibiting the adenyl cyclase (AC) activity also significantly reversed baicalin induced suppression of NLRP3 activation, highlighting the possibility that baicalin may modulate upstream components of PKA signaling."

29163487

---

➶

reach

"Thus, we conclude that baicalin induced autophagy activation, inhibited the activity of NLRP3 inflammasome through autophagic degradative mechanism, and restrained the secretion of IL-1beta."

29163427

---

➶

reach

"Together, these results suggested that baicalin suppressed NLRP3 inflammasome activation at least in part through the PKA signaling."

29163487

---

➶

reach

"In support of our findings, two separate studies provided evidence that baicalin could suppress the NLRP3 inflammasome pathway in piglet mononuclear phagocytes in response to LPS stimulation or Haemophilus parasuis infection."

29163487

---

➶

reach

"Collectively, these data demonstrated that baicalin can suppress NLRP3 inflammasome activation by, at least partly, modulating PKA signaling."

29163487

---

➶

reach

"Altogether, our results revealed that baicalin inhibited NLRP3 inflammasome activation at least partly through augmenting PKA signaling, highlighting its therapeutic potential for the treatment of NLRP3 related inflammatory diseases."

29163487

---

➶

reach

"Although we had shown that AC inhibitor could reverse baicalin mediated suppression of NLRP3, our data does not exclude the possibility that baicalin may regulate PKA signaling by affecting the activity of PDEs."

29163487

---

➶

reach

"Instead, baicalin could block NLRP3 inflammasome activation upon ATP or nigericin triggering, indicative of its action on the second signal for this inflammasome."

29163487

---

➶

reach

"Moreover, baicalin could inhibit the activation of NF-kappaB and NLRP3 inflammasome signaling pathway triggered by H. parasuis, which was first reported in the anti-inflammatory action during H. parasuis infection."

27502767

---

➶

reach

"Altogether, these results suggested that baicalin inhibited NLRP3 inflammasome activation at least partly through augmenting PKA signaling."

29163487

---

➶

reach

"In this study, we found that baicalin robustly suppressed NLRP3 inflammasome activation in LPS primed macrophages upon ATP or nigericin stimulation."

29163487

---

➶

reach

"Baicalin suppresses the activation of NLRP3 inflammasome."

29163427

---

➶

reach

"In line with the finding that baicalin inhibited NLRP3 inflammasome activation in vitro, baicalin administration in vivo significantly improved the survival of mice in bacterial sepsis."

29163487

---

➶

reach

"In this study, we used nigericin stimulation for 1h and found that baicalin significantly inhibited nigericin induced inflammasome activation and cell death in LPS primed macrophages, suggesting that baicalin could inhibit NLRP3 mediated pyroptosis."

29163487

---

➶

reach

"However, it was unclear whether baicalin could inhibit NLRP3 inflammasome activation at the triggering step (second signal)."

29163487

---

➶

reach

"Consistent with these studies, we in this study provided evidence that baicalin suppressed NLRP3 activation by modulating PKA activity."

29163487

---

➶

reach

"Those previous studies and our data indicated that baicalin robustly inhibited NLRP3 inflammasome activation to attenuate inflammatory responses during infections such as bacterial sepsis."

29163487

Resveratrol affects NLRP3

| 26

Resveratrol inhibits NLRP3. 26 / 26

| 26

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➶

reach

"NLRP3 inflammasome blockade by resveratrol appeared to be mediated by activating AMP activated Protein Kinase (AMPK), which could restrain mTOR/TTP/NLRP3 mRNA signalling."

31996295

---

➶

reach

"Resveratrol pretreatment also inhibited the activation of NLRP3 and caspase-1, and reduced the production of inflammatory cytokines and ROS."

29257276

---

➶

reach

"Resveratrol Protects against Sepsis Associated Encephalopathy and Inhibits the NLRP3 and IL-1beta Axis in Microglia."

26924896

---

➶

reach

"Resveratrol might inhibit NLRP3 activation by the above mentioned mechanisms, but it may also inhibit the NLRP3 and IL-1beta priming via sirt1, since sirt1 might prevent the transcriptional level of IL-1beta [XREF_BIBR]."

26924896

---

➶

reach

"Not surprisingly, resveratrol, the polyphenol present in the skin of grapes, another sirtuin activator, also inhibits NLRP3 inflammasome activation in mice by preserving mitochondrial function, and protects against hepatosteatosis, renal inflammation and LPS induced lung injury [XREF_BIBR - XREF_BIBR]."

27942750

---

➶

reach

"Resveratrol Suppresses Gut Derived NLRP3 Inflammasome Partly through Stabilizing Mast Cells in a Rat Model."

30670927

---

➶

reach

"Alternatively, the suppression of NLRP3 cytokine production and ROS by resveratrol in a separate rat TBI model was shown to be sirtuin 1 (SIRT1) dependent, illustrating the pleiotropic manner by which polyphenols suppress NLRP3 mediated neuroinflammation."

30210334

---

➶

reach

"Furthermore, Misawa et al. [XREF_BIBR] found that resveratrol might block the assembly of NLRP3 on endoplasmic reticulum and ASC on mitochondria, thereby inhibiting the activation of NLRP3 inflammasome."

26924896

---

➶

reach

"In line with the reduction of ASC specks, paclitaxel augmented NLRP3 inflammasome activation was also inhibited by resveratrol, NAD +, or MEC-17 siRNA knockdown."

30761140

---

➶

reach

"In conclusion, resveratrol improves the spatial memory in mice with SAE and inhibits the NLRP3 and IL-1beta axis in the microglia."

26924896

---

➶

reach

"Metformin and resveratrol protected mitochondrial integrity by inhibiting Drp1 activity and prevented NLRP3 inflammasome activation by suppressing ER stress, and thereby protected adipose function from high glucose insult."

27276511

---

➶

reach

"Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy."

25535911

---

➶

reach

"A study demonstrated that in BV2 microglial cell lines, resveratrol could inhibit NLR family pyrin domain containing 3 (NLRP3) activation and IL-1beta cleavage caused by ATP."

29850641

---

➶

reach

"Our data also provide evidence that resveratrol can attenuate NLRP3 inflammasome in a CIN model, as the level of renal NLRP3 in our CIN group was dramatically reduced by pretreatment with resveratrol in the RCIN group."

30691208

---

➶

reach

"Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation."

24629563

---

➶

reach

"Resveratrol inhibits the activation step of the NLRP3 inflammasome by suppressing mitochondrial damage."

25535911

---

➶

reach

"Our data indicate that resveratrol suppresses NLRP3 inflammasome activation by preserving mitochondrial integrity and by augmenting autophagy."

25535911

---

➶

reach

"Here, we report that resveratrol, a polyphenolic compound naturally produced by plants, inhibits NLRP3 inflammasome derived IL-1beta secretion and pyroptosis in macrophages."

25535911

---

➶

reach

"Resveratrol also reduced MC and NLRP3 inflammasome activation, which was consistent with the effects of cromolyn sodium."

30670927

---

➶

reach

"XREF_BIBR showed that the plant polyphenolic compound resveratrol, known to induce autophagy, suppresses mitochondrial damage in macrophages and thereby inhibits NLRP3 inflammasome activation and NLRP3 inflammasome mediated IL-1beta secretion and pyroptosis."

26594174

---

➶

reach

"Previous studies have shown that resveratrol can suppress NLRP3 and subsequent IL-1beta in sepsis models [XREF_BIBR]."

30691208

---

➶

reach

"One prior study reported that NLRP3 inflammasome in brain was involved in LPS induced depressive like behaviors in mice, and another showed that resveratrol improved the spatial memory of mice with cecal ligation and puncture and inhibited the NLRP3 and IL-1beta axis in microglia."

27923741

---

➶

reach

"Resveratrol was described to inhibit NLRP1, NLRP3, and NLRC4 activation by preventing mitochondrial damage and augmenting autophagy."

28588486

---

➶

reach

"Moreover, resveratrol was demonstrated to inhibit the NLRP3 and IL-1beta axis at both in vivo and in vitro levels."

26924896

---

➶

reach

"Resveratrol down-regulates NLRP3 inflammasome components in varicocelized rats."

29456821

---

➶

reach

"Resveratrol can also inhibit the NLRP3 and IL-1beta axis in hippocampus of SAE mice and microglial cells stimulated by LPS and ATP, which is critical for the development of SAE."

26924896

Curcumin affects NFKB1

5 | 20

Curcumin inhibits NFKB1. 25 / 25

5 | 20

---

➶

ctd

No evidence text available

19225048

---

➶

ctd

No evidence text available

16173963

---

➶

reach

"XREF_BIBR, XREF_BIBR Curcumin inhibits NFKB activity in different cell types (XREF_TABLE) and the inhibition of the NFKB pathway can be seen by decreased expression of NFKB."

24665206

---

➶

reach

"Interestingly, NFkB downstream effectors such as COX-2, PGE2and IL-8 were also down-regulated by curcumin treatment."

23111102

---

➶

reach

"Indeed, curcumin has also been shown to inhibit mediators of inflammation such as cyclo-oxygenase-2 and lipooxygenase (two enzymes involved in inflammation), inducible nitric oxide synthase (enzyme that catalyzes the production of nitric oxide), cytokines and NFKB."

27610163

---

➶

reach

"Curcumin has been shown to inhibit induction of AP-1 and NFkB in bone marrow stromal cells [XREF_BIBR]."

17979888

---

➶

reach

"XREF_BIBR - XREF_BIBR Curcumin could also decrease the expression of MAPKs down-stream of NFKB1 in order to inhibit paclitaxel induced upregulation of survival signaling events in HeLa cells."

26273408

---

➶

ctd

No evidence text available

16023083

---

➶

reach

"Curcumin treatment has been shown to reduce NF-kb activation during inflammatory events."

28948066

---

➶

reach

"Subsequently, curcumin inhibits the activation of NF-KB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs, and iNOS."

17569214

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➶

reach

"As shown in XREF_FIG, curcumin treatment for 24 h time-dependently reduced the activation of different NF-kappaB subunits (p50 and p65)."

25431425

---

➶

reach

"Curcumin treatment blocked activation of p50 and p65, which was significantly activated by pretreatment with 1 muM PGE 2 for 2 h (XREF_FIG)."

25431425

---

➶

reach

"Curcumin can inhibit NFKB activity indirectly by stabilization of NFKBIA."

24665206

---

➶

ctd

No evidence text available

17596214

---

➶

reach

"Curcumin, an active anti-inflammatory compound in Indian spices, can inhibit NFkB complex activation and IL-8 induction in gastric cells infected with H. pylori [XREF_BIBR, XREF_BIBR]."

20585917

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➶

reach

"Furthermore, increasing evidence indicates that curcumin inhibits NFkB activation, efficiently preventing cell death [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

23618527

---

➶

reach

"The supershift assay showed that TNFalpha increases neuroblastoma NF-kappaB activity through the canonical pathway, specifically through increases in the p50 and p65 subunits; curcumin blocked the p50 and p65 subunit activation as seen by antibody shift (XREF_FIG)."

22284765

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➶

reach

"NFkB reporter assay and western blot analysis of nuclear as well as cytosolic fractions of NFkB revealed that curcumin inhibits NFkB activation whereas inhibition was much less with dimc."

29621898

---

➶

reach

"Moreover, curcumin suppresses nuclear localization of p50 and all VIP effects mediated by p50 (COX-2 and PGE 2 and VEGF)."

25446255

---

➶

reach

"Among its many activities, which are mainly anti-inflammatory and anticancer, curcumin inhibits cytochrome P450s, down-regulates NFkB, and affects apoptosis and the cell cycle."

21279680

---

➶

reach

"However, pretreatment with PGE 2 attenuated curcumin induced inhibition of p50, p65, and RelB of NF-kappaB signaling (XREF_FIG)."

25431425

---

➶

reach

"Curcumin has been shown to down-regulate the NFkB signaling pathway thereby inducing apoptosis, which has been found be an important mechanism of AKI."

29311922

---

➶

reach

"Our results indicate that p50 activity is increased during MV and that both SN50 and curcumin treatment attenuates the increase in p50 activation (XREF_FIG)."

22080641

---

➶

ctd

No evidence text available

17041101

---

➶

reach

"Besides TNF inhibition, curcumin is also able to block phorbol ester and hydrogen perox- ide mediated activation of NF-KB (Singh and Aggarwal, 1995)."

9561563

Reactive oxygen species affects CASP1

| 2 22

Reactive oxygen species inhibits CASP1. 24 / 24

| 2 22

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➶

sparser

"In addition, caspase-1 is also unexpectedly directly inhibited by some ROS."

30288079

---

➶

reach

"This mechanism would likely be strictly regulated since ROS production downstream of many pattern recognition receptors alone is not sufficient to activate the NLRP3 inflammasome itself and conversely, overproduction of ROS inactivates caspase-1 by covalent modification [XREF_BIBR]."

20201015

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➶

reach

"Rather, they induced a cellular state inhibitory to both the autoproteolytic and substrate cleavage activities of caspase-1 which was reversed by the reactive oxygen species (ROS) scavenger N-acetyl-cysteine but not by reducing agents or nitric oxide pathway inhibitors."

24337744

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➶

reach

"In support of this, caspase-1 activation by hyperosmotic stress was inhibited by the mitochondrial ROS inhibitor MitoTEMPO, but not by the NADPH oxidase inhibitor apocynin or the xanthine oxidase inhibitor allopurinol (XREF_FIG)."

25959047

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➶

reach

"A recent study using pharmacologic ROS inhibitors and small hairpin RNA (shRNA) to knockdown p22 phox in human monocytic cell lines has shown that NOX activity and ROS stimulate rather than inhibit the activation of caspase-1."

25324778

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➶

reach

"Moreover, UgU elicited mitochondrial superoxide generation in a dose dependent manner, and a specific scavenger of mitochondrial reactive oxygen species (ROS) diminished UgU induced IL-1beta and caspase-1 activation."

28012441

---

➶

reach

"Autophagy of damaged mitochondria limits ROS modulated caspase-1 activation and seems to negatively regulate pyroptosis [XREF_BIBR]."

25140116

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➶

reach

"Although ROS scavengers potently inhibited RIPK3 dependent caspase 1 activity, they had no effects on RIPK3 dependent caspase 8 activation, indicating that RIPK3 regulates caspase 8 mediated pro-IL-1beta processing through a distinct mechanism."

28069136

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➶

reach

"The generation of reactive oxygen species (ROS) was proposed to be the common step in Nlrp3 activation largely based on the observation that caspase-1 activation is blocked by ROS inhibitors XREF_BIBR, XREF_BIBR, XREF_BIBR."

22005480

---

➶

reach

"Some of the disagreements over the role of ROS might be explained by mitochondrial DAMPs or the fact that high ROS levels can inhibit caspase-1."

26432659

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➶

reach

"This is in agreement with the finding that ROS actually inhibit caspase-1 through reversible oxidation and glutathionylation of two redox sensitive cysteine residues (C 397 and C 362), which is in contrast to an earlier study."

24367371

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➶

reach

"Moreover, increased ROS can also reversibly inactivate caspase-1 by oxidation and glutathionylation, indicating that increased ROS can also downregulate caspase-1 activity [XREF_BIBR]."

20060699

---

➶

reach

"In particular, Phox generated ROS downregulate caspase 1, thereby keeping the inflammasome in check and limiting antineutrophil cytoplasmic antibody (ANCA)-induced inflammation."

25798846

---

➶

reach

"XREF_BIBR, XREF_BIBR However, the role of ROS is still unclear since further studies suggest that increased ROS production may actually inhibit caspase-1 activation."

22096368

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➶

reach

"Furthermore, ROS was generated by pneumococcal infection and inhibited caspase-1 activation within 4 h of infection."

26683708

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➶

reach

"We also found that the ROS scavenger 4-hydroxyTEMPO (4-HT) prevented GB111-NH 2 -induced caspase-1 cleavage and activation (XREF_FIG)."

27011353

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➶

sparser

"Moreover, increased ROS can also reversibly inactivate caspase-1 by oxidation and glutathionylation, indicating that increased ROS can also downregulate caspase-1 activity [ xref ]."

20060699

---

➶

reach

"Autophagy of damaged mitochondria limits ROS modulated caspase-1 activation and seems to negatively regulate pyroptosis [XREF_BIBR]."

26491219

---

➶

reach

"Moreover, overproduction of ROS will impair caspase-1 competence by oxidation and glutathionylation."

28360909

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➶

reach

"In addition, we also demonstrated that ChC or 7-Keto-induced caspase-1 activation was blocked by MR redox platform disruption, ROS scavenging, or gene silencing of TXNIP, a ROS dependent binder of NLRP3 (XREF_FIG C)."

28633109

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➶

reach

"In the macrophages of superoxide dismutase (SOD) 1 deficient mice, higher level of ROS inhibits the activation of CASP1 [XREF_BIBR]."

32320383

---

➶

reach

"Vitamin C and/or irinotecan administration decreased the plasma level of ROS and IL-6 and increased the expression of collagen type I and caspase-1."

30504681

---

➶

reach

"In addition, caspase-1 is also unexpectedly directly inhibited by some ROS."

30288079

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➶

reach

"However, the role of ROS has been challenged XREF_BIBR, XREF_BIBR and the overproduction of ROS has been shown also to inhibit the activation of caspase-1 XREF_BIBR."

24244322

Acetylsalicylic acid affects IKBKB

4 | 1 4 15

Acetylsalicylic acid inhibits IKBKB. 24 / 24

4 | 1 4 15

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➶

ctd

No evidence text available

10480951

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➶

reach

"It has been shown that aspirin, as well as sodium salicylate, inhibits IKK-beta activity in vitro at millimolar concentration [XREF_BIBR] by binding to IKK-beta, thus, competing with ATP for the binding to the kinase, an event necessary to phosphorylate IkB [XREF_BIBR, XREF_BIBR]."

24281340

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➶

reach

"Sulindac [75], aspirin and salicylate [76] specifically inhibit IkKB kinase activity, and sanguinarine has also been shown to inhibit NFkB activation at the level of IkB phosphorylation [77]."

12419552

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➶

reach

"Yin et al. have reported that aspirin inhibits the activity of IKKbeta, which is the essential kinase in the NF-kappaB activation pathway [4]."

24613833

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➶

reach

"The use of the IKKbeta blocker aspirin or of other salicylates had a markedly positive effect on insulin resistance in patients with TD2M as well as in insulin resistant mouse models [XREF_BIBR]."

24897026

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➶

medscan

"Previous reports indicated that aspirin specifically inhibits IKKβ activity, and constitutively active form of IKKβ accelerates Adenomatous Polyposis Coli loss."

24613833

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➶

reach

"XREF_BIBR High doses of aspirin have been shown to inhibit IKK-beta and might therefore ameliorate insulin resistance and improve glucose tolerance in at least some patients with T2D."

25120374

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➶

sparser

"Glibenclamide achieves antidiabetic activity by binding with sulfonylurea receptor 1 (SUR1), which inhibits the conductance of the adenosine triphosphate (ATP)-dependent potassium (K ATP ) channel whereas aspirin inhibits the serine kinase IKKβ [ xref ]."

25775424

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➶

reach

"Aspirin inhibits certain enzymes (I-kappa-B-kinase-beta (IKK-beta)) an enzyme important in the cascade of signals that activate the nuclear factor NF-kappaB family of genes which regulate certain inflammatory and immune pathways."

12946657

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➶

reach

"High-dose aspirin inhibits cyclooxygenase and IkappaB kinase-beta and reduces fasting plasma glucose concentration, although there has not, as yet, been a large-scale trial to examine the effect of aspirin on the risk of developing diabetes."

16472047

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➶

reach

"Yin et al. have reported that aspirin is the specific inhibitor of IKKbeta, which is the essential kinase for NF-kappaB activation [4]."

24613833

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➶

ctd

No evidence text available

16472047

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➶

ctd

No evidence text available

15861417

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➶

sparser

"There is evidence that aspirin, which was shown to block NF-κB activation [183 , 184] , directly binds and inhibits IKKβ [185] ."

12507553

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➶

reach

"Lastly, direct inhibition of IKKbeta by aspirin, salicylate, and sulindac may be another mechanism that could account for the antiproliferative effects of these NSAIDs via downregulation of NF-kappaB-mediated proliferative genes such as interleukin-2 (IL-2), granulocyte-macrophage colony stimulating factor (GM-CSF), c-myc, cyclin D1, and COX-2, among others."

23875171

---

➶

reach

"The IKK inhibitors parthenolide and aspirin blocked the activities of infection induced IKKalpha and IKKbeta, leading to attenuation of nuclear translocation of NF-kappaB."

15618150

---

➶

reach

"Previous reports indicated that aspirin specifically inhibits IKKbeta activity, and constitutively active form of IKKbeta accelerates APC loss."

24613833

---

➶

sparser

"Aspirin, salicylate, and sulindac can directly bind and inhibit recombinant IKKβ, the upstream positive regulator of NF-κB ( xref )."

23875171

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➶

reach

"At a higher concentration, both nonacetylated salicylates and aspirin are known to inhibit the IKKbeta and NF-kappaB axis, an important regulator of inflammation [XREF_BIBR, XREF_BIBR]."

28042580

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➶

ctd

No evidence text available

16199534

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➶

reach

"Here we demonstrate that the anti-inflammatory agents aspirin and sodium salicylate specifically inhibit IKK-beta activity in vitro and in vivo."

9817203

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➶

sparser

"Lastly, direct inhibition of IKKβ by aspirin, salicylate, and sulindac may be another mechanism that could account for the antiproliferative effects of these NSAIDs via downregulation of NF-κB-mediated proliferative genes such as interleukin-2 (IL-2), granulocyte-macrophage colony-stimulating factor (GM-CSF), c-myc, cyclin D1, and COX-2, among others."

23875171

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➶

reach

"Recently, sodium salicylate and aspirin have been shown to inhibit activation of the transcription factor NF-kappaB by preventing IKK-beta from degradation."

25120374

---

➶

reach

"Whereas sulfasalazine was found to inhibit both IKKalpha and IKKbeta, aspirin and sodium salicylate were reported to specifically inhibit IKKbeta."

12110242

(-)-epigallocatechin 3-gallate affects STAT1

1 | 1 22

(-)-epigallocatechin 3-gallate inhibits STAT1. 24 / 24

1 | 1 22

---

➶

reach

"We next tested whether EGCG not only inhibits STAT1 but also enhances autophagy in primary cardiac myocytes."

21447043

---

➶

reach

"Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, has recently been reported to inhibit STAT-1 activity in noncardiac cells."

15319365

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➶

sparser

"EGCG inhibits STAT-1 to mediate protective effects of EGCG in myocardial I/R injury xref ."

24494192

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➶

reach

"This could be a mechanism by which EGCG inhibits STAT1 activation and related actions on cytokines and growth factors."

27102705

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➶

reach

"We found that EGCG inhibited the activation and binding of STAT1 to the IRF-1 promoter in response to IFN-gamma."

17270146

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➶

reach

"Although we do not exclude a possibility that the doses and timing used here might not be optimal for EGCG to inhibit DNMT1 and STAT1 (our hypothesis) or to mask immunostimulatory receptors (Kanamune et al.) and concede that refinement of EGCG treatment might result in GvHD prevention, our preliminary results do not corroborate or confirm those of Kanamune et al. and suggest that the effect of EGCG on GvHD is, at best, minimal."

23676554

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➶

reach

"Menegazzi and colleagues showed that interferon-gamma-induced STAT-1 activation in carcinoma derived cell lines of non gut origin was blocked by EGCG [XREF_BIBR]."

17374166

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➶

reach

"EGCG also reduced STAT1 activity in cells transiently expressing the STAT1 luciferase plasmid (XREF_FIG)."

28703809

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➶

reach

"Treatment with 2S,3R-6-methoxycarbonylgallocatechin (MCGE), an epigallocatechin gallate derivative isolated from black tea (Anhua dark tea), effectively suppresses STAT1 activation and inflammatory cytokines, and activates Nrf2 pathway to protect cells from reactive oxygen species production in UVB exposed keratinocyte cells (HaCaT)."

31743829

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➶

reach

"EGCG also inhibits STAT-1 activation."

18627310

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➶

reach

"58 STAT1 is upregulated in certain drug resistant cancers and inhibition of STAT1 by EGCG in colorectal cancer cells could contribute to the antitumor actions of this drug."

28703809

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➶

tas

No evidence text available

24417609

---

➶

reach

"EGCG inhibits STAT-1 to mediate protective effects of EGCG in myocardial I/R injury XREF_BIBR."

24494192

---

➶

reach

"EGCG remarkably inhibited the seawater aspiration induced increase of both STAT1 and p-STAT1 (XREF_FIG)."

24692852

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➶

reach

"In conclusion, although EGCG may be an effective inhibitor of both DNMT1 and STAT1, the treatment of EGCG after allo-HSCT does not result in prevention or reduction of GvHD in four different GvHD models, suggesting that EGCG treatment might not be an effective therapy against GvHD in the clinic."

23676554

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➶

reach

"This finding is consistent with the above result after inhibition of STAT1 by EGCG and confirms that STAT1 is important for doxorubicin induced HIF-1alpha upregulation."

23959856

---

➶

reach

"We further demonstrated that EGCG inhibited Th1 and Th17 differentiation by downregulating their corresponding transcription factors (STAT1 and T-bet for Th1, and STAT3 and RORgammat for Th17)."

22020144

---

➶

reach

"In various cell lines, including mammary carcinoma cell lines, cervical carcinoma cell line and hepatocarcinoma cell line EGCG inhibited activation of STAT1 without affecting STAT3 [XREF_BIBR]."

22583410

---

➶

reach

"To confirm the specificity of EGCG inhibition of STAT1, we transfected HEECs with STAT1 siRNA in monolayer HEECs."

26986625

---

➶

reach

"Thus, as a potential adjunct anti-inflammatory agent, EGCG can block STAT1 dependent events in gut epithelia and monocytes and prevent IFN-gamma-induced increased epithelial permeability."

15231486

---

➶

reach

"Treatment with IFN-gamma activated phospho-STAT1 was markedly attenuated by EGCG."

16174516

---

➶

reach

"EGCG also inhibited STAT1 regulated gene products, such as COX2 and TNF-alpha, which were increased by cisplatin (XREF_FIG)."

28703809

---

➶

reach

"EGCG pretreatment inhibited the increase of STAT1 and p-STAT1, whereas there was no difference of STAT1 and p-STAT1 between the control and EGCG group."

24692852

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➶

reach

"Our previous studies showed that (-)-epigallocatechin-3-gallate (EGCG) inhibits signal transducer activator of transcription 1 (STAT1) activation."

24255956

3',5'-cyclic AMP affects NLRP3

| 24

3',5'-cyclic AMP inhibits NLRP3. 24 / 24

| 24

---

➶

reach

"Taken together, these results indicate that cAMP specifically suppresses NLRP3 inflammasome activation."

23143333

---

➶

reach

"Although ligand of NLRP3 inflammasome is unclear, enhanced cAMP production inhibited the activation of the NLRP3 inflammasome through the direct regulatory role of cAMP on the NLRP3 complex [XREF_BIBR]."

27143817

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➶

reach

"Additionally, another report shows that cAMP negatively regulates the NLRP3 activation and that selected disease associated mutations have less sensitivity for cAMP regulation, which also could explain the constitutive activity XREF_BIBR."

25625584

---

➶

reach

"Recently, cAMP has been proposed to negatively regulate NLRP3 inflammasome activation (Lee et al., 2012), so we examined the role of cAMP in DA induced inflammasome inhibition."

25594175

---

➶

reach

"The NLRP3 inflammasome is inhibited by cAMP, and activated by ROS and ceramides [XREF_BIBR, XREF_BIBR]."

29497784

---

➶

reach

"Finally, we examined suppressive role of cyclic AMP (cAMP) on the IL-1beta secretion from patients ' PBMCs because cAMP has been shown to suppress NLRP3 inflammasome activation (XREF_SUPPLEMENTARY)."

25418813

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➶

reach

"Because cAMP suppresses NLRP3 inflammasome activation and binds to the NBD of NLRP3, which is the most common location of CAPS associated mutations 1, we considered the possible effect of these mutations on binding to cAMP."

23143333

---

➶

reach

"CASR stimulation also results in reduced intracellular cAMP, which independently activates the NLRP3 inflammasome."

23143333

---

➶

reach

"CaSR stimulation also results in reduced intracellular cAMP, which independently activates the NLRP3 inflammasome."

| PMC

---

➶

reach

"The role of cAMP in inflammasome activation remains unclear as one study has reported that cAMP can directly inhibit NLRP3, whereas another study reported that cAMP levels had no direct influence on inflammasome activation 92."

23702978

---

➶

reach

"failed to corroborate the finding that cAMP suppresses NLRP3 activation or that extracellular Ca 2+ reduces cAMP to relieve inhibition of NLRP3."

25879282

---

➶

reach

"Mitochondrial reactive oxygen species (ROS) generation, calcium influx, and reduction of cellular cyclic AMP (cAMP) have been reported to activate the NLRP3 inflammasome XREF_BIBR, 172, XREF_BIBR, though their effect (s) have been disputed 18."

26642356

---

➶

reach

"Inhibition of the NLRP3 inflammasome by cAMP."

27508077

---

➶

reach

"A decrease in cytosolic cAMP or an increase in intracellular calcium concentrations triggers the activation of the NLRP3 inflammasome."

24840700

---

➶

reach

"Recent studies suggest that nitric oxide (NO), Ca 2+ and cyclic AMP negatively regulate the NLRP3 inflammasome but the detailed mechanisms are unclear XREF_BIBR, XREF_BIBR."

27439607

---

➶

reach

"Forskolin, a PKA activator that increases cytoplasmic cAMP levels inhibits NLRP3 inflammasome activation by phosphorylation of the S295 residue in NLRP3."

29868015

---

➶

reach

"We found that the increase of the cAMP levels with adenylate cyclase (ADCY) activator forskolin inhibited NLRP3 inflammasome activation with a dose dependent manner, consistent with a previous report (Lee et al., 2012)."

25594175

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➶

reach

"While the increase of cAMP suppresses the NLRP3 inflammasome 22, it conversely potentiates pyrin inflammasome activation."

27270401

---

➶

reach

"NLRP3 inflammasome activation was increased with ADCY inhibitors and reduced by activators of ADCY and inhibitors of cAMP degradation."

25879282

---

➶

reach

"It was previously demonstrated that cAMP inhibits NLRP3 inflammasome through direct interaction with NLRP3 protein in mouse BMDM and in human PBMCs."

25917098

---

➶

reach

"To understand how cAMP might suppress NLRP3 inflammasome activation, we tested whether cAMP interacts directly with NLRP3."

23143333

---

➶

reach

"Mitochondrial reactive oxygen species (ROS) generation, calcium influx, and reduction of cellular cyclic AMP (cAMP) have been reported to activate the NLRP3 inflammasome XREF_BIBR, 172, XREF_BIBR, though their effect (s) have been disputed 18."

26642356

---

➶

reach

"Increase of intracellular cAMP by an activator of adenylate cyclase or an analog of cAMP, or a blockade of cAMP degradation by phosphodiesterase inhibitor decreased NLRP3 activation."

25917098

---

➶

reach

"To further confirm cAMP mediated NLRP3 inflammasome inhibition, we used 8-Bromo-cAMP, a cell permeable analog of cAMP."

25917098

Potassium(1+) affects NLRP3

| 22

Potassium(1+) inhibits NLRP3. 22 / 22

| 22

---

➶

reach

"Firstly, recent studies suggest a central role for P2X7 receptor mediated K+ efflux in NLRP3 activation, with prevention of K+ efflux abolishing NLRP3 in response to almost all known activators."

22096368

---

➶

reach

"Despite the inability of these inhibitors to trigger efflux of intracellular potassium, the addition of high extracellular potassium suppressed activation of the NLRP3 inflammasome."

22606244

---

➶

reach

"Interestingly, higher levels of extracellular K+ significantly reduced the PrP106-126-induced NALP3 upregulation (64% of the mRNA level seen in microglia treated with PrP106-126 only) but had no effect on ASC upregulation."

22531291

---

➶

reach

"It has also been described that potassium efflux is required for NLRP3 activation by various stimuli, a notion that was mainly attributed to the fact that potassium ionophores (e.g. Nigericin) are strong activators of the NLRP3 inflammasome, whereas high extracellular potassium concentrations that block K + efflux potently inhibit NLRP3 activation."

23666718

---

➶

reach

"ATP induced loss of intracellular potassium induces the activation of the NALP3 inflammasome."

21196401

---

➶

reach

"We also examined caspase-1 activation in infected wild-type and NLRC4 deficient macrophages in the presence of a high concentration of extracellular potassium (XREF_SUPPLEMENTARY), which is known to inhibit NLRP3 inflammasome activation XREF_BIBR."

23357873

---

➶

reach

"The conclusion that decreased intracellular potassium acts as a second signal to trigger activation of the NLRP3 inflammasome was based initially on the observation that loss of potassium induced by nigericin, a potassium ionophore, or by ATP results in the robust release of IL-1beta from cells in an NLRP3 dependent manner XREF_BIBR, XREF_BIBR."

22606244

---

➶

reach

"One study has demonstrated that because of autocrine and paracrine P2X7 activation by secreted ATP, a decrease in K+ levels (< 90mM) in the cytoplasm can activate NLRP3 inflammasome."

30113480

---

➶

reach

"The ability of high extracellular potassium to suppress activation of the NLRP3 inflammasome by multiple proinflammatory agonists XREF_BIBR has been used to support a model demonstrating that decreased cellular potassium constitutes a general trigger for inflammasome activation."

22606244

---

➶

reach

"Our data suggest that cells in high potassium may suppress the activation of the NLRP3 inflammasome by two independent mechanisms : 1) by restoring intracellular potassium to normal levels in cells that have undergone leakage of potassium via pore formation (e.g. by nigericin) or stimulation of P2X7 receptors (e.g. by ATP), thereby preventing translational inhibition; and 2) by suppressing the activation of caspase-1 by an unknown mechanism."

22606244

---

➶

reach

"Reduction of intracellular potassium level induces a conformational change of NLRP3 allowing its activation [XREF_BIBR, XREF_BIBR]."

27519871

---

➶

reach

"Notably, reduction of the intracellular K+ concentration was sufficient to activate NLRP3, whereas an increase in intracellular Na+ modulated but was not strictly required for inflammasome activation."

23809161

---

➶

reach

"Potassium efflux is implicated in the activation mechanism for the inflammasome, because NLRP3 inflammasome activation can be triggered by low intracellular potassium, but prevented by culturing cells in high potassium containing media."

21876553

---

➶

reach

"Our results demonstrating the rescue of protein translation by increased extracellular potassium in BMDM exposed to nigericin or ATP (XREF_FIG) suggested to us that impairment of ribosomal activity may explain why loss of cellular potassium activates the NLRP3 inflammasome."

22606244

---

➶

reach

"As expected, increased extracellular potassium also inhibited Nlrp3 dependent silica induced, but not AIM2 dependent Francisella tularensis LVS induced, IL-1beta production (XREF_FIG)."

23954133

---

➶

reach

"It has been shown that reduction of the intracellular K+ concentration can activate the NLRP3 inflammasome, linking ion efflux to innate immunity [XREF_BIBR]."

28060952

---

➶

reach

"Because increased extracellular potassium blocks the activation of the NLRP3 inflammasome by MSU, it has been concluded that MSU acts through a mechanism that involves a decreased concentration of cellular potassium XREF_BIBR, XREF_BIBR, XREF_BIBR."

22606244

---

➶

reach

"This leads to a potassium dysregulation and activation of NLRP3."

24498450

---

➶

reach

"Previous study has found that high extracellular potassium concentration (130mM) can block the activation of NALP3 inflammasome and inhibit the activation of caspase-1."

29250536

---

➶

reach

"Many of these agents are capable of triggering K+ efflux from the cell, and indeed, addition of excess K+ to the extracellular space suppresses activation of the NLRP3 inflammasome and IL-1beta release (Petrilli et al., 2007; Munoz-Planillo et al., 2013)."

26027935

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➶

reach

"Polydatin attenuates potassium oxonate induced hyperuricemia and kidney inflammation by inhibiting NF-kappaB and NLRP3 inflammasome activation via the AMPK and SIRT1 pathway."

28428988

---

➶

reach

"To elucidate the role of potassium efflux as an upstream signal of NLRP3 inflammasome activation, equine PBMCs were treated with blockers of potassium efflux in the presence of NLRP3 triggers."

32297137

Lipopolysaccharide affects STAT1

| 22

Lipopolysaccharide inhibits STAT1. 22 / 22

| 22

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➶

reach

"Western blotting revealed that LPS induced activation of STAT1 and STAT5 in macrophages was significantly inhibited by CopA3."

22969062

---

➶

reach

"Overall, this research indicates that beta-glucan inhibits the production of the NO in the E. coli LPS activated murine macrophages via the HO-1 induction and inhibits the STAT1 signaling pathways."

27488844

---

➶

reach

"We postulate that KPG might involve in weak reduction of LPS induced STAT1 (Ser 727) instead of p38."

29470957

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➶

reach

"In a human leukemia cell line THP-1, tipifarnib inhibited lipopolysaccharide (LPS)-induced transcription of chemokines [monocyte chemotactic protein (MCP) -1 and MCP-2], cytokines [interleukin (IL)-1beta, IL-6, and interferon (IFN) beta], signaling molecules (MyD88 and STAT-1), proteases [matrix metalloproteinase (MMP-9)], and receptors (urokinase receptor)."

16352705

---

➶

reach

"Melatonin inhibits Prevotella intermedia lipopolysaccharide induced production of nitric oxide and interleukin-6 in murine macrophages by suppressing NF-kappaB and STAT1 activity."

21158907

---

➶

reach

"Our results revealed that in n-6 mice, LPS induced STAT1, STAT3 and JAK2 activation was also attenuated as compared to n3/n -6 mice."

18973601

---

➶

reach

"Thus, in contrast to HF 's AAR activation in T cells, the mode of action of halofuginone in primary macrophages is marked by an activation of NFkappaB and a disruption of LPS induced STAT1 activation."

27211859

---

➶

reach

"The current data indicate that NaN 3 pretreatment of macrophage like cell lines resulted in the suppression of LPS induced activation of STAT1 and IkappaBzeta without affecting NF-kappaB activation."

28391993

---

➶

reach

"Deletion of SOCS3 had no effect on LPS induced NF-kappaB p65 and ERK1/2 activation, but enhanced LPS induced STAT1 and STAT3 activation (XREF_FIG)."

22925925

---

➶

reach

"As expected, LPS stimulated IgM production and Prdm1 expression were significantly lower in the Stat1 knockdown cells compared with the luciferase knockdown control (XREF_FIG)."

27849553

---

➶

reach

"However, both CBD and THC decreased the activation of the LPS induced STAT1 transcription factor, a key player in IFNbeta dependent proinflammatory processes."

19910459

---

➶

reach

"LPS induced Stat1 activation was diminished in Ahr KO macrophages compared with that in WT cells (XREF_FIG)."

19703987

---

➶

reach

"LPS (TLR4 signaling) administration to macrophages induced integrin beta3 activation and enhanced STAT1 signaling; disruption of integrin beta3 (such as beta3KOM) diminished this enhancement of STAT1 signaling."

27216180

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➶

reach

"However, it showed a significant inhibitory effect on LPS induced activation of STAT1 and STAT3 proteins in macrophages."

28778215

---

➶

reach

"LPS induced lung injury was attenuated in STAT1 knockout mice."

22450807

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➶

reach

"As observed when BMDCs were treated with LPS, LPS pre-treatment of BMDMs inhibited the Stat1 response to IFNalpha and IL-6, but not IFNgamma (XREF_FIG)."

19494279

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➶

reach

"Collectively, these data suggested that aloin attenuated the LPS triggered inflammatory response by suppressing STAT1 and STAT3 activation, but not MAPKs, IKK or IkappaB."

30066904

---

➶

reach

"Absence of Tyk2 strongly reduces LPS mediated Stat1 activation, as well as delays the onset and shortens the duration of the response."

11070173

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➶

reach

"We reported that CBD reduces the activity of the NF-kappaB pathway and upregulates the activation of STAT3 transcription factor in LPS stimulated BV-2 cells, and that both CBD and THC decrease the activation of the LPS induced STAT1 transcription factor, a key player in IFNbeta dependent pro inflammatory processes XREF_BIBR."

23637839

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➶

reach

"It was reported that LPS induced STAT1 activation was inhibited by quercetin in combination with its profound inhibitory effects on iNOS and NF-kappaB expression, which are persistently involved in activation of interleukin-2 (IL-2) as shown in XREF_FIG [XREF_BIBR]."

27589790

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➶

reach

"Like live bacteria, LPS inhibited the ability of Stat1 to respond to multiple stimuli in T cells and macrophages in a dose dependent manner (XREF_FIG)."

19494279

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➶

reach

"In other studies, Shirota and co-workers reported that blockade of STAT1 phosphorylation using synthetic oligonucleotides confers resistance to LPS induced injury whereas Kim et al demonstrated that LPS induced production of the pro inflammatory mediator HMGB1 is attenuated in STAT1 deficient mice."

22777121

Curcumin affects JUN

1 | 1 1 19

Curcumin inhibits JUN. 22 / 22

1 | 1 1 19

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➶

reach

"Curcumin inhibits the activity of activator protein-1, a transcription factor implicated in the expression of Abeta [XREF_BIBR]."

32283762

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➶

eidos

"In addition , curcumin inhibits the activation of NF-kB and the expression of c-jun , c-fos , c-myc ."

16216010

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➶

reach

"This suggests that curcumin inhibits the proliferation of endometrial carcinoma cells by downregulating ERK and c-Jun signaling pathway activity."

32083122

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➶

reach

"Curcumin also suppressed the JNK and c-Jun activation in those cells."

19763044

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➶

reach

"Curcumin also inhibits 12-O- tetradecanoyl phorbol-13-acetate-mediated induction of c-jun / AP-1, ornithine decarboxylase, and protein kinase C activity in murine NIH/3T3 cells (Huang et al., 1992)."

11322385

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➶

reach

"We previously reported that curcumin, the yellow pigment of turmeric, inhibited the formation of the Fos, Jun, and DNA complex."

12104052

---

➶

reach

"We also tested whether inhibition of nuclear factor kappa-B (NF-kappaB) and activator protein-1 (AP-1) by curcumin is involved in these mechanisms."

16461119

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➶

reach

"The role of JNK (and thereby c-Jun) and NF-kappaB transcription factor in the induction of MMP-13 by TNF-alpha was explored by pretreating human chondrocytes or SW1353 chondrocytic cells with curcumin (diferuloylmethane), a dietary pigment from Curcuma longa that inhibits JNK, c-Jun, and NF-kappaB activation by PMA or TNF-alpha treatment and has strong antiinflammatory and antioxidant properties [22-24]."

12878172

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➶

reach

"Curcumin is a potent inhibitor of the transcription factor activator protein-1 which plays an essential role in osteoclastogenesis."

19699734

---

➶

reach

"We previously reported that curcumin, the yellow pigment of turmeric, inhibited the formation of the Fos, Jun, and DNA complex."

12104052

---

➶

reach

"Curcumin is a potent inhibitor of the transcriptional factors activator protein-1 and nuclear factor-kappaB."

10799655

---

➶

reach

"Curcumin derivatives inhibit the formation of Jun, Fos, and DNA complex independently of their conserved cysteine residues."

16053715

---

➶

reach

"Curcumin has been proven to inhibit p-Jun N-terminal kinase p-JNK and c-jun [XREF_BIBR] in neuropathic pain model and inhibit tumor necrosis factor TNF-alpha and nitrogen monoxide (NO) in a diabetic mouse model of neuropathic pain [XREF_BIBR]."

25135388

---

➶

reach

"Results also revealed that curcumin treatment decreased LPS induced activation of two transcription factors -- nuclear factors kappaB (NF-kappaB) and activator protein-1 (AP-1)."

18368483

---

➶

reach

"Curcumin inhibits NF-kappaB and activator protein 1, responsible for cytokine transcription, in cell lines."

25628521

---

➶

reach

"New and known symmetrical curcumin derivatives inhibit the formation of Fos, Jun, and DNA complex."

12104052

---

➶

reach

"Curcumin and emodin block the CSN directed c-Jun signaling pathway, which results in diminished c-Jun steady state levels in HeLa cells."

16083495

---

➶

medscan

"In fact, curcumin not only inhibits DNA binding of c-Jun/activating protein-1 transcription factors but also downregulates c-Jun gene transcription [ ]."

26767865

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➶

reach

"XREF_FIG shows that curcumin selectively inhibits the transcriptional activity of c-Jun and c-Fos but not c-Jun and Fra -1 in the absence of exogenous Zac1 (XREF_FIG; closed bars)."

26633653

---

➶

reach

"Up-regulation of COX-2 and the above ER signaling factors was reversed by treatment of the infected cells with curcumin which specifically inhibits the JNK and c-Jun pathway."

16036795

---

➶

reach

"The role of JNK (and thereby c-Jun) and NF-kappaB transcription factor in the induction of MMP-13 by TNF-alpha was explored by pretreating human chondrocytes or SW1353 chondrocytic cells with curcumin (diferuloylmethane), a dietary pigment from Curcuma longa that inhibits JNK, c-Jun, and NF-kappaB activation by PMA or TNF-alpha treatment and has strong antiinflammatory and antioxidant properties [22-24]."

12878172

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➶

ctd

No evidence text available

17596214

Bortezomib affects RELA

4 | 1 17

Bortezomib inhibits RELA. 22 / 22

4 | 1 17

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➶

reach

"The cytoplasmic to nuclear translocation and activation of NF-kappaB is a proteosome-dependant process, and bortezomib has been shown to inhibit nuclear activation of the RelA and NF-kappaB1 subunits in HNSCC [XREF_BIBR]."

21299897

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➶

reach

"Bortezomib also induced degradation of p65 in a dose dependent manner (XREF_FIG), starting at 10-15 nM, and a time dependent manner, starting after 12 h (XREF_FIG)."

| PMC

---

➶

reach

"Bortezomib treatment in steatotic liver donor reduces NF-kappaB p65 activation and inflammatory I/R injury, improving transplant outcomes of steatotic grafts in a rat model [XREF_BIBR]."

26325610

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➶

reach

"Furthermore, inhibition of pan-caspases abolished Bortezomib induced degradation of p65, p105 and Sp proteins, but not that of IkappaBalpha."

| PMC

---

➶

reach

"In our study, Bortezomib degraded not only IkappaBalpha protein but also the p65 subunit of NF-kappaB."

| PMC

---

➶

medscan

"Bortezomib also downregulates the NF-κB pathway by inducing nuclear translocation of IκBα, resulting in suppression of NF-κB p65/50-dependent transcription . (A) Diagram of NF-kB promoters on FANCD2 and BRCA1 genes. (B) Expression by qPCR of FANCD2 following proteasome inhibition ±30 nM (A549) or 50 nM (NCI-H460) bortezomib or ± inducible PSMA1 short hairpin RNA, and ±10 Gy ionizing radiation."

24040035

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➶

ctd

No evidence text available

20471514

---

➶

reach

"Moreover, we found that Bortezomib degraded p65 in leukemia cells."

| PMC

---

➶

ctd

No evidence text available

12893773

---

➶

reach

"Similarly, siRNA experiments that inhibit p65 expression and mimic Bortezomib induced degradation of p65 proteins, confirmed that absence or inhibition of p65 does not lead to apoptosis, as represented by the absence of PARP cleavage (XREF_FIG, left panel), nor to induced cell death (XREF_FIG, right panel)."

| PMC

---

➶

reach

"They showed that proteasome inhibitor bortezomib more effectively inhibited nuclear localization of RELA and p50 than cREL or alternate pathway subunits NF-kappaB2 or RELB in tumor specimens and lines from patients with HNSCC."

18694378

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➶

reach

"Western blotting showed that Bortezomib induced degradation of Sp3 and p65 in both cytoplasm and nucleus."

| PMC

---

➶

reach

"While bortezomib inhibited proteasome, NF-kappaB p65 subunit, and prosurvival genes, 18 clinical activity of bortezomib plus reirradiation was limited."

21750205

---

➶

ctd

No evidence text available

16904634

---

➶

ctd

No evidence text available

17164350

---

➶

reach

"In contrast, p65 mRNA expression was unaffected or even increased in MOLT4 cells, implying that bortezomib perturbs the stability of p65 via NICD downregulation as suggested previously."

24301524

---

➶

reach

"Bortezomib indeed decreases nuclear retention of p65 preferentially in PARP inhibitor resistant lines compared to parental UWB1.289 or HCC1937 cells, suggesting that it seems to inhibit NF-kappaB signaling in the setting of acquired PARP resistance."

25686825

---

➶

reach

"As shown in XREF_FIG, bortezomib reduces the level of nuclear p65 protein in U266 myeloma cells."

24067362

---

➶

reach

"Bortezomib degraded both cytoplasmic and nuclear pools of p65."

| PMC

---

➶

reach

"We found that Bortezomib degrades p65 and IkappaBalpha through different mechanisms."

| PMC

---

➶

reach

"Why Bortezomib degrades p65 is not clear."

| PMC

---

➶

reach

"After 3 or 7 days of treatment, Disease Activity Index (DAI) as well as histological scores and NF-kappaB p65 protein expression were significantly reduced in mice treated with bortezomib at a dose of 0.6 or 1 mg/kg/day."

28487944

Bevirimat affects CASP1

| 22

Bevirimat inhibits CASP1. 22 / 22

| 22

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➶

reach

"Although the mechanism by which PA-457 prevents cleavage of CA-SP1 has not been fully defined, recent data suggest that the compound binds directly the CA-SP1 region of an oligomeric form of Gag within a partially or fully assembled immature particle (Sakalian et al."

17586320

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➶

reach

"A recently developed HIV-1 inhibitor, PA-457 or bevirimat, targets the CA-SP1 cleavage site to prevent virion maturation."

18657842

---

➶

reach

"Furthermore, in our in vitro maturation system, the maturation inhibitor BVM not only blocked cleavage of CA-SP1 but also partially protected the MA-CA cleavage site."

27958264

---

➶

reach

"BVM specifically inhibits CA-SP1 cleavage, which occurs late in the Gag proteolytic cleavage cascade [XREF_BIBR, XREF_BIBR]."

22888428

---

➶

reach

"To determine whether BVM disrupts CA-SP1 processing in the context of the L363I and M367I mutations, we evaluated the effect of this compound on levels of CA, CA *, and CA-SP1 in virions by quantitative radioimmunoprecipitation analysis."

20172577

---

➶

reach

"Furthermore, bevirimat was shown to block CA-SP1 processing in vitro when Gag self assembled into VLPs but not in the absence of assembly [91]."

18468560

---

➶

reach

"This observation suggests that Bevirimat not only prevents CA-SP1 cleavage but also may stabilize the immature lattice 33."

21762804

---

➶

reach

"Although bevirimat specifically disrupts CA-SP1 cleavage, it has been shown that the compound does not affect the viral PR function XREF_BIBR, XREF_BIBR."

26713265

---

➶

reach

"The precise mechanism by which BVM inhibits CA-SP1 cleavage has not been established."

19782103

---

➶

reach

"Bevirimat causes a dose dependent inhibition of CA-SP1 cleavage and severely impairs HIV infectivity in human thymocytes."

21602280

---

➶

reach

"Further, BVM binds to a pocket formed during Gag oligomerization, as BVM does not inhibit CA-SP1 processing in the context of monomeric Gag in solution, but rather requires Gag assembly for its activity."

19782103

---

➶

reach

"BVM does not inhibit CA-SP1 processing in the context of monomeric Gag in solution [XREF_BIBR], but instead requires Gag assembly for its activity [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

22888428

---

➶

reach

"Since bevirimat treatment of virus producing cells does not completely block CA-SP1 processing XREF_BIBR, the degree of cleavage in the resulting particle preparations was determined by immunoblot (XREF_FIG)."

24915417

---

➶

reach

"The observation that bevirimat delays but does not completely block CA-SP1 processing suggests that the presence of uncleaved CA-SP1 may disrupt the maturation process in trans."

20172577

---

➶

reach

"The precise mechanism by which bevirimat prevents cleavage of CA-SP1 has not been fully elucidated; however, a large body of experimental data appears to suggest that the CA-SP1 junction of an oligomeric form of Gag within the immature particles is molecular target of bevirimat XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."

26713265

---

➶

reach

"Two working models have been proposed to explain how bevirimat blocks processing of CA-SP1 cleavage site."

26713265

---

➶

reach

"We found that the BVM analogs could effectively block CA-SP1 processing of HIV-1 clade C in contrast to the parental BVM, which was completely inactive against the clade C clones."

27264714

---

➶

reach

"First, bevirimat does not inhibit CA-SP1 processing in the context of monomeric Gag in solution but instead requires immature virus assembly for its activity."

19534569

---

➶

reach

"XREF_BIBR - XREF_BIBR Bevirimat (XREF_FIG) inhibits HIV-1 maturation by preventing the cleavage of CA-SP1 (p25) Gag into Capsid (p24) and SP1 (p2)."

21084190

---

➶

reach

"A recently developed HIV-1 inhibitor, PA-457 or bevirimat, targets the CA-SP1 cleavage site to prevent virion maturation."

18657842

---

➶

reach

"It is noteworthy that BVM disrupts but does not completely block CA-SP1 processing; some mature CA is generated even at high concentrations of the compound."

23144615

---

➶

reach

"Previous studies demonstrated that BVM does not completely block CA-SP1 processing but acts as a kinetic inhibitor to delay PR mediated cleavage at this site."

20172577

Tofacitinib citrate affects JAK1

21 |

Tofacitinib citrate inhibits JAK1. 21 / 21

21 |

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➶

tas

No evidence text available

22591402

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➶

tas

No evidence text available

27137359

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➶

tas

No evidence text available

29156136

---

➶

tas

No evidence text available

23540648

---

➶

tas

No evidence text available

24398382

---

➶

tas

No evidence text available

26927423

---

➶

tas

No evidence text available

21105711

---

➶

tas

No evidence text available

23214979

---

➶

tas

No evidence text available

22037378

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➶

tas

No evidence text available

21106455

---

➶

tas

No evidence text available

24417533

---

➶

tas

No evidence text available

25369270

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➶

tas

No evidence text available

24461299

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➶

tas

No evidence text available

26059596

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➶

tas

No evidence text available

25262541

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➶

tas

No evidence text available

14593182

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➶

tas

No evidence text available

29298069

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➶

tas

No evidence text available

19053756

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➶

tas

No evidence text available

23659214

---

➶

tas

No evidence text available

23541670

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➶

tas

No evidence text available

18183025

TASOCITINIB affects JAK1

21 |

TASOCITINIB inhibits JAK1. 21 / 21

21 |

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➶

tas

No evidence text available

21105711

---

➶

tas

No evidence text available

23541670

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➶

tas

No evidence text available

14593182

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➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

21106455

---

➶

tas

No evidence text available

24461299

---

➶

tas

No evidence text available

26059596

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➶

tas

No evidence text available

24417533

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➶

tas

No evidence text available

22037378

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➶

tas

No evidence text available

29156136

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➶

tas

No evidence text available

24398382

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➶

tas

No evidence text available

25369270

---

➶

tas

No evidence text available

23659214

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➶

tas

No evidence text available

25262541

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➶

tas

No evidence text available

22591402

---

➶

tas

No evidence text available

19053756

---

➶

tas

No evidence text available

23214979

---

➶

tas

No evidence text available

29298069

---

➶

tas

No evidence text available

27137359

---

➶

tas

No evidence text available

26927423

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➶

tas

No evidence text available

23540648

NAC affects NLRP3

| 21

NAC inhibits NLRP3. 21 / 21

| 21

---

➶

reach

"NAC has also been shown to inhibit the NLRP3 inflammasome pathway (IL1beta and IL18) in vitro, and decrease plasma TNF-a in human clinical trials."

| PMC

---

➶

reach

"Additionally, the level of NLRP3 was lower in groups treated with NAC than in the control group."

29993180

---

➶

reach

"We found that NAC inhibited the activation of NLRP3 inflammasomes to alleviate cell injury in cardiomyocytes after H/R injury in both LG and HG conditions."

29062465

---

➶

reach

"Anti-oxidants L-carnitine and NAC significantly suppress ROS overproduction and BRCC36 production, block caspase-8 activation, and largely reverse or restore the imbalance of activated NLRP3 and suppressed NLRP6."

28238526

---

➶

reach

"N-acetyl-l-cysteine (NAC), a reductant, inhibits NLRP3 activation in different models XREF_BIBR XREF_BIBR XREF_BIBR."

28084303

---

➶

reach

"Furthermore, the mechanism study found that PPVI could activate the NF-kappaB signaling pathway via increasing reactive oxygen species (ROS) levels in A549 and H1299 cells, and N -acetyl-L-cysteine (NAC), a scavenger of ROS, remarkably inhibited the cell death, and the activation of NF-kappaB and the NLRP3 inflammasome in PPVI treated A549 and H1299 cells."

31941010

---

➶

reach

"We reported previously that high glucose and lipopolysaccharide activate ROS-TXNIP-NLRP3 inflammasome signaling in GMCs, but ROS inhibitor N-acetylcysteine (NAC) could not completely inhibit the activation of NLRP3 inflammasome induced by high glucose, suggesting that there may be other pathways by which high glucose primes ROS-NLRP3 inflammasome signaling [XREF_BIBR]."

29675433

---

➶

reach

"NAC improved the cell viability and inhibited NLRP3 inflammasome activation."

30378301

---

➶

reach

"In the present study, we found that the ROS inhibitor NAC significantly reduced the production of IL-1beta, and blocked NALP3 and ASC upregulation after exposure to PrP106-126, suggesting a role of ROS generation in the activation of the inflammasome in PrP106-126-stimulated microglia."

22531291

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➶

reach

"NAC did not affect modification of IRAK1 in response to Pam3CSK4 stimulation, as evidenced by the disappearance of the IRAK1 band (XREF_FIG, lower panel), indicating that NAC inhibits NLRP3 activation downstream of IRAK1."

24043892

---

➶

reach

"Meanwhile, NAC pretreatment inhibited ZnO-NPs-induced activation of NF-kappaB and NLRP3 inflammasome."

28870124

---

➶

reach

"NAC has also been shown to inhibit the NLRP3 inflammasome pathway (IL1beta and IL18) in vitro, and decrease plasma TNF-a in human clinical trials."

32504923

---

➶

reach

"NAC significantly abrogated PrP106-126-induced NALP3 and ASC upregulation; the mRNA levels of NALP3 and ASC significantly decreased after NAC treatment in PrP106-126-treated microglia and dropped to 68% and 54%, respectively, of the levels seen in microglia treated with PrP106-126 only."

22531291

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➶

reach

"In this study, NAC significantly diminished IL-1beta secretion triggered by mycobacterial infection, suggesting that ROS are involved in M. kansasii induced NLRP3 inflammasome activation; however the source of ROS is currently unknown."

22558425

---

➶

reach

"The cell-permeable reducing agent dithiothreitol and the reactive oxygen species (ROS) inhibitor N-acetyl-L-cysteine (NAC) did not inhibit the hyperosmotic expression of the NLRP3 gene (XREF_FIG)."

27788256

---

➶

reach

"The use of ROS scavenger N-acetylcysteine (NAC) partially reversed NLRP3 inflammasome activity in cells exposed to burn serum."

26576075

---

➶

reach

"NAC has also been shown to inhibit the NLRP3 inflammasome pathway (IL1beta and IL18) in vitro, and decrease plasma TNF-a."

| PMC

---

➶

reach

"High concentrations of NAC have been reported to inhibit NLRP3 activation."

23809161

---

➶

reach

"The addition of NAC prior to BSA exposure prevented Nlrp3 upregulation and co-localisation with fissured mitochondria."

25281528

---

➶

reach

"NAC, a kind of ROS inhibitor, dramatically inhibited NLRP3 inflammasome activation and decreased the secretion of mature IL-1beta."

29993180

---

➶

reach

"Moreover, the ROS scavenger NAC inhibited NLRP3 inflammasome activation, indicated by the decreased expression of NLRP3 (XREF_FIG), ASC (XREF_FIG), and procaspase-1 (XREF_FIG) induced by HG and H/R (XREF_FIG)."

29062465

5Z-7-oxozeaenol affects MAP3K7

5 | 16

5Z-7-oxozeaenol inhibits MAP3K7. 16 / 16

| 16

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➶

reach

"Cell culture experiments demonstrated that either siRNA knockdown or 5Z-7-oxozeaenol inhibition of TAK1 significantly attenuated NADPH oxidase activation and superoxide production induced by CD40L and CD40 stimulation."

25050617

---

➶

reach

"A fungal resorcylic lactone, 5Z-7-oxozeaenol, is known to inhibit the kinase activity of purified TAK1."

27426734

---

➶

reach

"As TAK1 inhibition by 5Z-7-oxozeaenol is neuroprotective, the observed decrease seen in vehicle treated mice in pTAK1 in the reperfusion period may reflect an attempt at endogenous neuroprotection."

22683931

---

➶

reach

"Together, TAK1 inhibition by 5Z-7-oxozeaenol significantly enhanced the inhibitory effect of Dox and VP-16 on anchorage independent neuroblastoma cell growth."

23700229

---

➶

reach

"5Z-7-oxozeaenol selectively inhibits the catalytic activity of TAK1 but has minimal effects on other MAP kinases or JNK."

22683931

---

➶

reach

"5Z-7-oxozeaenol and SB203580, which block TAK1 and p38 kinase respectively, abrogated the LTB4 inhibitory effect on L-type calcium channels."

26584289

---

➶

reach

"The specific TAK1 inhibitor 5Z-7-oxozeaenol (5Z-7-ox; O9890-1 MG; Sigma) was administered intraperitoneally to NTG and TRAF3-LTG mice (5mgkg -1) in parallel to inhibit TAK1 activation."

26882989

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➶

reach

"This compound did not effectively inhibit the catalytic activities of the MEKK1 or ASK1 MAPKKKs, suggesting that 5Z-7-oxozeaenol is a selective inhibitor of TAK1."

12624112

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➶

reach

"In the heart, unlike our findings in the brain, inhibition of TAK1 by 5Z-7-oxozeaenol led to increased cardiomyocyte death after cardiac ischemia, suggesting that TAK1 has anti-apoptotic effects."

22683931

---

➶

reach

"5Z-7-oxozeaenol, a resorcylic lactone of fungal origin, has been reported to selectively inhibit TAK1."

20168333

---

➶

reach

"5Z-7-oxozeaenol, a resorcylic acid lactone derived from fungus, is a powerful inhibitor of TAK1."

29163172

---

➶

reach

"One such compound is 5Z-7-oxozeaenol, which selectively inhibits TAK-1 and has been shown to reduce inflammation and enhance the sensitivity of breast and pancreatic cancer cells to various chemotherapeutic agents, further highlighting the central role that IRAK signaling plays in chemotherapy resistance."

25452754

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➶

reach

"We first tested whether inhibition of TAK1 activity by 5Z-7-oxozeaenol (5Z), an inhibitor of TAK1, was able to block S. Typhimurium induced autophagy and AMPK activation."

29752434

---

➶

reach

"For Tak1 inhibitor treatment, the specific Tak1 inhibitor 5Z-7-oxozeaenol (5Z-7-ox; O9890-1 MG; Sigma, St Louis, MO, USA) was administered intraperitoneally to male non transgenic (NTG) and Traf6-TG mice (5mgkg -1) to inhibit Tak1 activation."

27249171

---

➶

reach

"In cell culture, 5Z-7-oxozeaenol blocked interleukin-1-induced activation of TAK1, JNK and p38 MAPK, IkappaB kinases, and NF-kappaB, resulting in inhibition of cyclooxgenase-2 production."

12624112

---

➶

reach

"Results from ELISA showed that 5Z-7-oxozeaenol effectively decreased the level of p-TAK1 and inflammatory cytokines (IL-1beta and TNF-alpha) in primary alveolar macrophages isolated from silica exposed rats in dose dependent manners (XREF_SUPPLEMENTARY)."

28698801

5Z-7-oxozeaenol inhibits MAP3K7. 5 / 5

5 |

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No evidence text available

26481152

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➶

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No evidence text available

25529738

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➶

tas

No evidence text available

28011204

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No evidence text available

27448772

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➶

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No evidence text available

21316225

Tofacitinib affects TYK2

16 | 4

Tofacitinib inhibits TYK2. 20 / 20

16 | 4

---

➶

tas

No evidence text available

21106455

---

➶

tas

No evidence text available

24461299

---

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tas

No evidence text available

21105711

---

➶

reach

"Tofacitinib potently inhibits JAK1, JAK2, and JAK3 and, to a lesser extent, TYK2 in biochemical assay (IC50 = 3.2, 4.1, 1.6, and 34 nM respectively)."

32326669

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➶

tas

No evidence text available

26927423

---

➶

reach

"Thus, tofacitinib that inhibits JAK1, JAK2, JAK3 and, to a lesser extent, TYK2 is used in the clinic for treating RA patients in many countries."

28456914

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➶

tas

No evidence text available

---

➶

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No evidence text available

29156136

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➶

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No evidence text available

23214979

---

➶

tas

No evidence text available

23659214

---

➶

tas

No evidence text available

18183025

---

➶

reach

"Tofacitinib inhibits JAK1 and JAK2 to a greater degree than was initially thought and also inhibits Tyk2 marginally."

| PMC

---

➶

tas

No evidence text available

29298069

---

➶

tas

No evidence text available

24417533

---

➶

tas

No evidence text available

19053756

---

➶

tas

No evidence text available

23668484

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

24398382

---

➶

reach

"Tofacitinib inhibits JAK1 and JAK2 to a greater degree than was initially thought and also inhibits Tyk2 marginally.139, 140, 141, 142, 143, 144Tofacitinib is the most potent (inhibitory potency of 1 nM) and selective JAK3 inhibitor developed to date."

| PMC

---

➶

tas

No evidence text available

22591402

Sulforaphane affects NLRP3

| 20

Sulforaphane inhibits NLRP3. 20 / 20

| 20

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"SFN inhibited ligand independent activation of the NLRP3 inflammasome, suggesting that SFN may act directly on the NLRP3 inflammasome complex."

29340626

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"In our results, SFN attenuated activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome."

27423466

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"SFN suppressed NLRP3 inflammasome activation induced by MSU crystals, adenosine triphosphate and nigericin but not by poly (dA : dT) in primary mouse macrophages, independent of the reactive oxygen species pathway."

29340626

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"Our data revealed that NLRP3 inflammasome activation is associated with cerulein induced inflammation in acini and suppressed by SFN."

27847555

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"Sulforaphane also down-regulated the expressions of cleaved caspase-1, IL-1beta, and IL-18 and inhibited the activation of NLRP3 inflammasome."

32508671

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"Consistently, oral administration of SFN blocked MSU-crystal-induced activation of the NLRP3 inflammasome in a mouse air pouch gout model."

29340626

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"This neuroprotective effect is likely exerted by Sulforaphane inhibited NLRP3 inflammasome activation caused by the downregulation of NLRP3, the induction of cleaved caspase-1, and thus the reduction of IL-1beta and IL-18."

28189971

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"In this study, we found that sulforaphane (1-isothiocyanato-4-methylsulfinylbutane; SFN) suppressed the activation of the NLRP3 inflammasome activation induced by saturated fatty acid in hepatocytes."

27075683

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"We investigated whether SFN inhibited the activation of the NLRP3 inflammasome induced by the saturated fatty acid, palmitate, in primary mouse hepatocytes."

27075683

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reach

"Also, Yang et al. 38 showed that NLRP3 inhibition by sulforaphane, a compound derived from cruciferous vegehtables, resulted in amelioration of hepatic steatosis in high-fat fed mice 38."

28615649

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"In a peritonitis model of acute gout, SFN treatment significantly reduced MSU crystal induced IL-1beta production, demonstrating that SFN inhibits the NLRP3 inflammasome function in vivo."

27672241

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"SFN Inhibited NLRP3 Inflammasome Activation in Cerulein Stimulated Pancreatic Acinar Cells."

27847555

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reach

"Sulforaphane treatment inhibits NLRP3 inflammasome activation and the downregulation of cleaved caspase-1, while reducing IL-1beta and IL-18 expression."

28189971

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reach

"Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome."

27423466

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reach

"Sulforaphane suppresses the activation of the NLRP3 inflammasome induced by saturated fatty acid in primary hepatocytes."

27075683

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"For example, the ketone body, b-hydroxybutyrate, which specifically inhibits NLRP3 inflammasome activation via potassium efflux blockade, and the naturally derived antioxidant, sulforaphane, have been shown to attenuate MSU induced responses in murine models of gout."

29892292

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"The results showed that sulforaphane preferentially inhibited cathepsin B- and caspase-1-dependent NLRP3 inflammasome activation induced by mostly Abeta1-42 monomers, an effect that potently reduced excessive secretion of the proinflammatory cytokine interleukin-1beta (IL-1beta)."

26827637

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"These results demonstrate that SFN suppressed the activation of the NLRP3 inflammasome induced by saturated fatty acid in hepatocytes."

27075683

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reach

"SFN also exerted antioxidant effects, activated the Nrf2 pathway, and inhibited the NLRP3 inflammasome in Muller cells."

30606939

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reach

"A few NLRP3 inflammasome inhibitors, including sulforaphane, isoliquiritigenin, beta-hydroxybutyrate (BHB), flufenamic acid, mefenamic acid, 3,4-methylenedioxy-beta-nitrostyrene (MNS), parthenolide, BAY 11-7082, INF39, and MCC950, have been developed, but there is no evidence showing that these compounds can specifically and directly inhibit NLRP3 itself."

29021150

P-menthan-3-ol affects ITCH

| 9 11

P-menthan-3-ol inhibits ITCH. 20 / 20

| 9 11

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"These findings suggest that B5-I neurons are required for the inhibition of itch by menthol ( xref B)."

24726382

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"Finally, we show that B5-I neurons are innervated by menthol-, capsaicin-, and mustard oil responsive sensory neurons and are required for the inhibition of itch by menthol."

24726382

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➶

reach

"Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for minutes to hours."

24726382

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sparser

"Direct evidence that dynorphin released from spinal interneurons is involved in suppressing itch was provided by showing that chloroquine-evoked itch could be inhibited by menthol in wild-type mice, but not inBhlhb5 −/− mice, in which the dynorphin cells are largely absent. xref "

28326935

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"Finally, we show that B5-I neurons are innervated by menthol-, capsaicin-, and mustard oil-responsive sensory neurons and are required for the inhibition of itch by menthol."

24726382

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reach

"To directly test this possibility, we developed a mouse model of inhibition of itch by menthol."

24726382

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➶

reach

"Together, these data suggest that B5-I neurons mediate the inhibition of itch by menthol and likely other chemical counterstimuli."

24726382

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reach

"XREF_BIBR, XREF_BIBR - XREF_BIBR Of note, menthol at concentrations of 1 to 3% have been reported to relieve pruritus, while higher dose preparations such as 10% solutions can induce irritation."

21767774

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➶

sparser

"To directly test this possibility, we developed a mouse model of inhibition of itch by menthol."

24726382

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reach

"Direct evidence that dynorphin released from spinal interneurons is involved in suppressing itch was provided by showing that chloroquine evoked itch could be inhibited by menthol in wild-type mice, but not in Bhlhb5 -/- mice, in which the dynorphin cells are largely absent."

28326935

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➶

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"In contrast, Bhlhb5 -/- mice showed no significant inhibition of itch by menthol (XREF_FIG A)."

24726382

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➶

sparser

"In contrast,Bhlhb5 −/− mice showed no significant inhibition of itch by menthol ( xref A)."

24726382

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reach

"Moreover, we show that menthol inhibits itch in wild-type mice but does not do so in mice lacking B5-I neurons."

24726382

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sparser

"Finally, we demonstrate that B5-I neurons are innervated by capsaicin-, mustard oil-, and menthol-responsive primary afferents and are required for inhibition of itch by menthol."

24726382

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➶

reach

"These findings suggest that B5-I neurons are required for the inhibition of itch by menthol (XREF_FIG B)."

24726382

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➶

reach

"Finally, we show that, whereas menthol inhibits itch in wild-type mice, it does not do so in mice that lack B5-I neurons."

24726382

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➶

sparser

"Moreover, we show that menthol inhibits itch in wild-type mice but does not do so in mice lacking B5-I neurons."

24726382

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➶

sparser

"Together, these data suggest that B5-I neurons mediate the inhibition of itch by menthol and likely other chemical counterstimuli."

24726382

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➶

sparser

"Finally, we show that, whereas menthol inhibits itch in wild-type mice, it does not do so in mice that lack B5-I neurons."

24726382

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➶

reach

"Finally, we demonstrate that B5-I neurons are innervated by capsaicin-, mustard oil-, and menthol responsive primary afferents and are required for inhibition of itch by menthol."

24726382

Ethanol affects NLRP3

| 20

Ethanol inhibits NLRP3. 20 / 20

| 20

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"Also lending credibility to the hypothesis that ethanol inhibits apical events in Nlrp3 inflammasome activation is our finding that the alcohol can reduce IL-1beta secretion when given up to 15 minutes after stimulation with ATP (XREF_FIG)."

27421477

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"Ethanol inhibited the activation of the NLRP3 inflammasome by cholesterol crystals, SAA, ATP, and nigericin over a wide range of concentrations (2.5/1000-20/1000 corresponding to 43 mM-343 mM)."

24244322

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"10 We showed earlier that an ethanol extract of A. cinnamomea suppresses NLRP3 inflammasome activation and secretion of pro inflammatory IL-1beta and IL-18 in macrophages."

28630461

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"Ethanol blocks NLRP3 inflammasome activation in several cell types."

27421477

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reach

"Correspondingly, ethanol induced NLRP3 inflammasome activation was decreased in cells treated with HIF-1alpha inhibitor CAY10585."

25722794

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"We report here that acute ethanol administration can override the effects of chronic ethanol and inhibit NLRP3 inflammasome activation (XREF_FIG), helping to explain why alcoholics who have a background of chronic inflammatory symptoms still experience transient immunosuppression after binge drinking."

28463821

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"Ethanol treatment at each time point before ATP addition and up to 15 minutes after stimulation was found to inhibit Nlrp3 inflammasome activation, and consistent with previous experiments, ethanol treatment had no impact on macrophage priming and TNF production (XREF_FIG)."

27421477

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"Consistent with ethanol 's inability to inhibit the Nlrp1b inflammasome, this demonstrates that ethanol does act to prevent NLRP3 inflammasome activation at the level of ASC speck formation."

27421477

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reach

"Recently, Hoyt et al. reported that acute ethanol administration dose dependently -- as discussed before -- inhibited the activation of the NLRP3 inflammasome, addressing the impact of alcohol on the stimulation of the protein tyrosine phosphatase [XREF_BIBR]."

32366053

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"Some evidence on the conflicting effects of ethanol on NLRP3 inflammasome activation has been presented : Ethanol markedly attenuated activation of the NLRP3 inflammasome in response to diverse danger signals, including ATP and nigericin, in lipopolysaccharide (LPS)-primed macrophages."

32469177

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"It has been shown that ethanol blocks the NLRP3 inflammasome activation in several cell types, including human peripheral blood mononuclear cells, murine bone marrow derived dendritic cells and neutrophils."

32366053

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reach

"We show that ethanol can specifically inhibit activation of the NLRP3 inflammasome, resulting in attenuated IL-1beta and caspase-1 cleavage and secretion, as well as diminished ASC speck formation, without affecting potassium efflux, in a mouse macrophage cell line (J774), mouse bone marrow derived dendritic cells, mouse neutrophils, and human PBMCs."

27421477

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"In addition to its direct toxicity, ethanol has two contrasting effects on the immune system : the nucleotide oligomerization domain like receptor pyrin domain-containing-3 (NLRP3) inflammasome is inhibited by acute ethanol exposure but activated by chronic ethanol exposure."

30447168

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"This indicates that ethanol does not inhibit the Nlrp3 inflammasome by blocking potassium efflux from stimulated cells, and is likely acting downstream of this critical point."

27421477

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reach

"These results mean that in both mouse and human cells, and in multiple cell types, ethanol is able to inhibit NLRP3 activation and IL-1beta production."

27421477

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reach

"Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation."

27421477

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reach

"The NLRP3 inflammasome, a multi protein intracellular pattern recognition receptor complex that facilitates the cleavage and secretion of the pro inflammatory cytokines IL-1beta and IL-18, can be inhibited by ethanol and we sought to better understand the mechanism through which this occurs and whether chemically similar molecules exert comparable effects."

27421477

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➶

reach

"Ethanol inhibits activation of NLRP3 and AIM2 inflammasomes in human macrophages -- a novel anti-inflammatory action of alcohol."

24244322

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➶

reach

"Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation."

27421477

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reach

"Our results demonstrate that ethanol antagonizes the NLRP3 inflammasome at an apical event in its activation through the stimulation of protein tyrosine phosphatases, an effect shared by other short-chain alcohols."

27421477

N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide affects TBK1

1 1 | 18

N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide inhibits TBK1. 20 / 20

1 1 | 18

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"MuV induced p-p65 and p-IRF3 levels in Sertoli cells were evidently reduced by a 2-h pretreatment of cells with BAY11-7082 (inhibitor of IkappaBalpha degradation) and BX795 (inhibitor of TBK1), respectively (XREF_FIG, left panels)."

26776505

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"Moreover, GM-DCs in which TBK1 and IKKepsilon were inhibited by BX795 showed substantial impairment in the phosphorylation of Akt at Ser473 and Thr308 and of PRAS40 and the ribosomal protein S6, and this was more profound than the inhibition observed after inhibition of PI (3) K or mTOR (XREF_FIG and XREF_SUPPLEMENTARY)."

24562310

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"Interestingly BX795, a molecule which inhibits TBK1 and IKKepsilon, has recently been shown to inhibit IFN-I production and signaling in human PBMCs with a mutation induced interferonopathy [8]."

29673738

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reach

"To inhibit TBK1, cells were treated with 0.5 muM BX795 (Axon Medchem or Tocris Bioscience)."

26656453

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"In vitro, BX795 can also inhibit TBK1, PDK1, Aurora B, MARK1, MARK2, MARK4, NUAK1, MLK1, MLK2, MLK3 with the range of 5-111 nM [XREF_BIBR]."

25474241

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"Inhibition of TBK1 by BX795 or knockdown of TBK1 by shTBK1 lentivirus blocked the capacity of MVNP to up-regulate IL6 gene expression in both NIH3T3 cells and primary BMM, as well as blocked the MVNP induced increase in osteoclast numbers after RANKL or TNF-alpha stimulation."

23794264

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"As such, we carried out a series of experiments by using BX795 that potently inhibits TBK1 activity XREF_BIBR."

28150813

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"Treatment with 5 muM BX795 (a pharmacological inhibitor of TBK1, also blocker of IFN-beta) and siTBK1 increased the bacterial load of intracellular M. bovis in both J774a.1 and BMDM macrophages after 24 and 48 h of infection."

30042930

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"Firstly, BX795, which can also inhibit TBK1, PDK1, p38 and JNK resulted in a significant reduction in PSA mRNA and protein levels and also reduced AR levels consistent with the CAY10576 data (XREF_SUPPLEMENTARY)."

32324216

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"The compound BX795 was developed as an inhibitor of the kinase PDK1 and was later discovered to potently inhibit TBK1."

23453972

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➶

signor

No evidence text available

Other

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"Although initially developed as a PDK1 inhibitor, recent studies have found that BX795 can also inhibit TANK binding kinase-1 (TBK1) and closely related IkappaB kinase epsilon (IKKepsilon)."

24352480

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"To determine if these kinases are involved in the ability of C5a and C3a to suppress IFN-beta production, we used CGI-1746 to inhibit BTK, Wortmannin to inhibit PI3K and Akt, U0126 to inhibit Erk, BX795 to inhibit TBK1, and SB202190 to inhibit p38 MAPK."

28275134

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"These data together support further exploration of the potential of TBK1 inhibitors as treatment for IFNpos systemic autoimmune diseases.A limitation of this study is that BX795 inhibits not only TBK1 but also IKKepsilon, which is in addition to being downstream of TLR3,4 also downstream of the IFNAR."

29673738

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"We estimate that CCT128930 inhibits only pS6 (and not pRAS40 and pAKT), and that BX795 inhibits the mTOR pathway rather than TBK1, at concentrations of 3.33 and 10 muM."

27148873

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"We next tested if TBK1 inhibition by BX795 provoked mitotic defects or spindle abnormalities."

26656453

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No evidence text available

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"Chemical inhibition of HSP90 (by 17-DMAG) or of TBK1 (by BX795) decreased ISD stimulated Ifnb1 and CXCL10 production in mouse lung fibroblasts and human MoDCs, similar to the reductions in these cytokines caused by CDC37 inhibition (XREF_FIG and XREF_SUPPLEMENTARY)."

23263557

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"BX795 [originally developed as a 3phosphoinositidedependent protein kinase 1 (PDK1)] [90] and a series of azabenzimidazole derivatives [91] inhibit both IKKe and TBK1 at low nanomolar concentrations [92] ."

23395611

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"Moreover, TBK1 and AKT, transforming growth factor activated kinase (TAK)-1/c-Jun N-terminal kinase (JNK)/mitogen-activated protein kinase kinase 4 (MKK4) for AP-1 activation, and Janus kinase 2 (JAK2)/STAT1 were inhibited by BX795."

31926936

Salicylic acid affects IKBKB

| 19

Salicylic acid inhibits IKBKB. 19 / 19

| 19

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"In the present study, we wished to test the hypothesis that sodium salicylate, which inhibits IKKbeta, prevents hepatic insulin resistance caused by short-term elevation of FFA."

17951543

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"Salicylate inhibits IKKbeta, to prevent the deleterious effects of excess FFA on insulin signaling and action [XREF_BIBR, XREF_BIBR]."

27128935

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"To support this finding, inhibition of IKKbeta by salicylate was effective in ameliorating inflammation mediated insulin resistance."

23761785

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reach

"However, it has been shown that salicylate may reverse TNF-alpha-induced insulin resistance independently of IKK-2 and NF-kappaB inhibition [XREF_BIBR]."

20820848

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"Clinical studies have found that Salsalate, a prodrug of salicylate which suppresses inflammation, attenuates IKKbeta and NF-kappaB activity, improves glycemic control in patients with type-2 diabetes, [XREF_BIBR] and alleviates IR."

28025032

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reach

"Whereas sulfasalazine was found to inhibit both IKKalpha and IKKbeta, aspirin and sodium salicylate were reported to specifically inhibit IKKbeta."

12110242

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➶

reach

"We hypothesized that sodium salicylate would reduce IKKbeta, leading to reduced TNFalpha and improved insulin signaling in the BBZDR and Wor obese rat model of type 2 diabetes."

25874611

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reach

"High concentrations of sodium salicylate are known to mediate its anti-inflammatory property by inhibiting the cellular kinase IKK-beta, as opposed to working through its classical target cyclooxygenase (COXs) [XREF_BIBR]."

25874611

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➶

reach

"Yuan et al. [XREF_BIBR] demonstrated that reduced signaling through the IKK-beta pathway inhibition by sodium salicylate in obese mice is accompanied by improved insulin sensitivity."

27034691

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reach

"Recently, sodium salicylate and aspirin have been shown to inhibit activation of the transcription factor NF-kappaB by preventing IKK-beta from degradation."

25120374

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reach

"Here we demonstrate that the anti-inflammatory agents aspirin and sodium salicylate specifically inhibit IKK-beta activity in vitro and in vivo."

9817203

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➶

reach

"Yin et al. subsequently demonstrated that salicylate specifically inhibits IKKbeta activity in cell lines in vivo and when the agent is added to the kinase in vitro [XREF_BIBR]."

28718829

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➶

reach

"Salicylic acid and SP600125 partially inhibited IKKbeta and JNK, respectively, which indicated distinct roles for these two kinases in the phosphorylation of IRS1 at the two serine sites."

16896943

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➶

reach

"Sulindac [75], aspirin and salicylate [76] specifically inhibit IkKB kinase activity, and sanguinarine has also been shown to inhibit NFkB activation at the level of IkB phosphorylation [77]."

12419552

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reach

"Salicylate also dramatically inhibited IKKbeta and NF-kappaB activation evoked by PA stimulation."

22766331

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➶

reach

"It has been shown that aspirin, as well as sodium salicylate, inhibits IKK-beta activity in vitro at millimolar concentration [XREF_BIBR] by binding to IKK-beta, thus, competing with ATP for the binding to the kinase, an event necessary to phosphorylate IkB [XREF_BIBR, XREF_BIBR]."

24281340

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"In particular, salicylate is known to inhibit the activity of IKKbeta, and pretreatment of salicylate in lipid infused rats rescues glucose tolerance back to similar levels seen in control rats when compared with lipid infusion alone [XREF_BIBR]."

20798864

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reach

"Insulin resistance was improved by systemic neutralization of IL-6 or salicylate inhibition of IKK-beta."

15685173

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➶

reach

"In vitro, salicylate treatment comparably inhibited the kinase activity of overexpressed IKKalpha and IKKbeta and also decreased p38 kinase activity."

10753891

Oroxylin A(1-) affects NLRP3

| 19

Oroxylin A(1-) inhibits NLRP3. 19 / 19

| 19

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➶

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"Oroxylin A blocked NLRP3 inflammasome activation through inhibiting the NF-kappaB signaling."

28938606

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➶

reach

"These findings suggested that oroxylin A inhibited NLRP3 inflammasome activation and subsequent IL-1beta secretion in THP-Ms."

28938606

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➶

reach

"These results illustrated that oroxylin A inhibited NLRP3 inflammasome activation through blocking NF-kappaB signaling."

28938606

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➶

reach

"Therefore, we confirmed that oroxylin A could down-regulate the activation of NLRP3 inflammasome, with decreased levels of caspase-1, IL-1beta and NLRP3 in colon samples of DSS induced colitis mice."

28938606

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➶

reach

"Our findings demonstrated that oroxylin A inhibited NLRP3 inflammasome activation and could potentially be used for the treatment of IBD."

28938606

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➶

reach

"Furthermore, we also observed the negative effect of oroxylin A on cytosolic assembly of ASC speck after inflammasome activation, suggesting that oroxylin A could also block the formation of NLRP3 inflammasome."

28938606

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➶

reach

"To confirm the results of in vivo study, two types of macrophages were used here, and it was found that oroxylin A could down-regulate the activation of NLRP3 inflammasome in both THP-1-derived macrophages and BMDMs."

28938606

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➶

reach

"Taken together, we concluded that oroxylin A inhibited the activation of NLRP3 inflammsome by blocking NF-kappaB signaling."

28938606

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➶

reach

"Taken together, these findings suggested that oroxylin A markedly suppressed NLRP3 inflammasome activation through inhibiting NF-kappaB pathway in vivo."

28938606

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➶

reach

"Next, we investigated the underlying mechanisms which the oroxylin A inhibited NLRP3 inflammasome activation."

28938606

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➶

reach

"In this study, we found that oroxylin A remarkably attenuated the symptoms of murine colitis and decreased the activation of NLRP3 inflammasome induced by DSS in colitis model."

28938606

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➶

reach

"Taken together, these data indicated that oroxylin A inhibited NLRP3 inflammasome activation in BMDMs."

28938606

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➶

reach

"Results illuminated that oroxylin A inhibited NLRP3 inflammasome activation by reducing ROS accumulation."

32289481

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➶

reach

"NLRP3 dependent caspase-1 activation and the secretion of IL-1beta were dose-dependently inhibited by oroxylin A."

28938606

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➶

reach

"By contrast, a recent study by Zhou and colleagues showed that Nlrp3 inhibition by the flavonoid oroxylin A may have beneficial effects against colitis in DSS treated mice."

29868004

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➶

reach

"Moreover, the mRNA expressions of NLRP3 and IL-1beta were also inhibited by oroxylin A in a dose dependent manner, suggesting that oroxylin A might inhibit NLRP3 inflammasome activation via affecting the priming step."

28938606

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➶

reach

"The above results demonstrated that oroxylin A could inhibit NLRP3 inflammasome activation via suppression of the priming step."

28938606

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➶

reach

"Oroxylin A inhibits colitis by inactivating NLRP3 inflammasome."

28938606

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➶

reach

"Oroxylin A inhibited NLRP3 inflammasome activation in THP-Ms and BMDMs."

28938606

2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]-3-azetidinyl]acetonitrile affects JAK1

5 | 14

2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]-3-azetidinyl]acetonitrile inhibits JAK1. 19 / 19

5 | 14

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➶

tas

No evidence text available

24417533

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➶

reach

"Baricitinib inhibits JAK1 and JAK2 and therefore may help manage inflammation XREF_BIBR."

32259575

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➶

reach

"Baricitinib blocks JAK1 and JAK2 in a highly selective way, interrupting the pathways of several cytokines considered important in RA pathogenesis [XREF_BIBR]."

29623147

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➶

tas

No evidence text available

26351728

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➶

tas

No evidence text available

29298069

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➶

reach

"JAK1 and JAK2 inhibition by baricitinib in diabetic kidney disease : results from a Phase 2 randomized controlled clinical trial."

29481660

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➶

reach

"The primary objective of the RA-BEGIN study was to evaluate baricitinib, an oral tsDMARD that selectively inhibits JAK1 and JAK2, as monotherapy or combined with MTX compared to MTX monotherapy in patients with active RA and no prior DMARD therapy or limited prior MTX therapy."

28923098

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reach

"Clinical trials about the effects of Tocilizumab (recombinant IL-6 monoclonal antibody) and Baricitinib (an oral administrated selective inhibitor of the JAK1 and JAK2) on COVID-19 are recruiting patients."

| PMC

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➶

reach

"Baricitinib inhibits selectively JAK1 and JAK2 [XREF_BIBR]."

| PMC

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➶

reach

"However, this has not been reported for baricitinib (at doses 2-4mg once daily) in clinical use for RA although baricitinib inhibits JAK1 and JAK2 with equal potency, highlighting the dose dependency of adverse effects [XREF_BIBR]."

30701418

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"38 Notably, in spite of the (partially) distinct pharmacodynamic effects of the two compounds (ie, tofacitinib predominantly inhibiting JAK1 and JAK3, baricitinib predominantly inhibiting JAK1 and JAK2), their safety profile is very similar, suggesting that the actual in vivo effects might not be predicted entirely by in vitro " selectivity " assays."

32676568

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➶

reach

"Tofacitinib selectively inhibits the janus-kinase (JAK) 1 and 3, while baricitinib blocks JAK1 and JAK2 pathways."

32290218

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➶

reach

"Baricitinib can inhibit both AAK1 and GAK (approved dosage of 2-4 mg daily) and can selectively inhibit JAK 1 and 2, thus reducing the inflammatory effects of Il-6 via the JAK-STAT signaling pathway."

32754159

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➶

tas

No evidence text available

27137359

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➶

tas

No evidence text available

26701356

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➶

reach

"It is notable that the Incyte compound Baricitinib (INCB-28050) has been reported to inhibit both JAK1 and JAK2 and its ability to inhibit JAK1 in rodent models [XREF_BIBR] has led to trials of the drug in rheumatoid arthritis and psoriasis."

23028408

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➶

reach

"The use of JAK1 and JAK2 inhibitors such as ruxolitinib and baricitinib for GvHD prophylaxis may limit the need for expensive and labor-intensive ex vivo cellular manipulations 38 and may also reduce the use of broadly immunosuppressive agents that may themselves contribute to disease relapse, morbidity, and mortality after allo-HSCT."

29691471

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➶

reach

"Baricitinib, which preferentially inhibits JAK1 and JAK2, is effective for the treatment of rheumatoid arthritis XREF_BIBR, XREF_BIBR and has been recently reported to ameliorate ocular disease in a case of off-label use for mucous membrane pemphigoid."

30582071

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➶

reach

"Baricitinib is a reversible inhibitor of JAK1 and JAK 2."

30448290

Celastrol affects NLRP3

| 3 16

Celastrol inhibits NLRP3. 16 / 16

| 16

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➶

reach

"These results suggest that celastrol inhibits NLRP3 inflammasome activation in part by suppression of ROS production."

28978034

---

➶

reach

"These data suggest that celastrol inhibits NLRP3 inflammasome activation through disrupting NLRP3 mediated ASC complex formation."

28978034

---

➶

reach

"These results demonstrate that enhanced autophagy by celastrol contributes to celastrol mediated NLRP3 inflammasome inhibition."

28978034

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➶

reach

"Intriguingly, 3-MA treatment could impair celastrol induced NLRP3 inflammasome inhibition, indicating that autophagy plays a critical role in celastrol induced NLRP3 inflammasome inhibition in systemic inflammation."

28978034

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➶

reach

"Moreover, celastrol treatment markedly decreased mRNA expression caspase-1, NLRP3 and ASC in colon tissue."

28978034

---

➶

reach

"Celastrol specifically inhibits the activation of NLRP3 inflammasome."

28726161

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➶

reach

"Celastrol significantly suppresses inflammation by reducing the secretion of IL-1beta and IL-18, and inactivating the NLRP3 inflammasomes and caspase-1 in LPS and ATP primed macrophage cells."

29491837

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➶

reach

"As expected, LPS treated wild type mice has decreased survival, compared with celastrol treated mice or Caspase-1 (TM)/(TM) mice, implying that celastrol can attenuate NLRP3 inflammasome activation in this model."

28978034

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➶

reach

"In summary, our findings demonstrate that celastrol inhibits NLRP3 inflammasome activation through autophagy activation."

28978034

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➶

reach

"Importantly, we observed that pretreatment of 3-MA enhanced IL-1beta production and reversed celastrol induced NLRP3 inflammasome inhibition (XREF_SUPPLEMENTARY, Figure XREF_FIG and XREF_FIG)."

28978034

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➶

reach

"We thus sought to determine whether celastrol could inhibit NLRP3 inflammasome activation by promoting autophagy."

28978034

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➶

reach

"As celastrol has multiple effects on inflammation, then we sought to determine whether celastrol inhibit NLRP3 inflammasome activation in other immune cells, apart from murine peritoneal macrophages."

28978034

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➶

reach

"Here, we show that celastrol abolishes the NLRP3 inflammasome activation, inhibits subsequent caspase-1 activation and IL-1beta secretion both in vitro and in vivo."

28978034

---

➶

reach

"Celastrol inhibits NLRP3 inflammasome activation in various stimulus and different cell types."

28978034

---

➶

reach

"Celastrol driven autophagy mediates NLRP3 inflammasome inhibition."

28978034

---

➶

reach

"Interestingly, both NAC and Mito-TEMPO significantly inhibited IL-1beta secretion, implying that celastrol inhibited NLRP3 inflammasome partially through decreasing ROS production."

28978034

Celastrol inhibits NLRP3. 3 / 3

| 3

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➶

sparser

"Notably, interruption of ASC oligomerization and autophagy activation are involved in NLRP3 inflammasome inactivation by celastrol."

28978034

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➶

sparser

"Intriguingly, 3-MA treatment could impair celastrol-induced NLRP3 inflammasome inhibition (Figure xref ), indicating that autophagy plays a critical role in celastrol-induced NLRP3 inflammasome inhibition in systemic inflammation."

28978034

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➶

sparser

"Importantly, we observed that pretreatment of 3-MA enhanced IL-1β production and reversed celastrol-induced NLRP3 inflammasome inhibition ( xref , Figure xref and xref )."

28978034

Quercetin affects NLRP3

| 18

Quercetin inhibits NLRP3. 18 / 18

| 18

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➶

reach

"NLRP3 inflammasome inhibition by quercetin is independent of autophagy."

28148962

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➶

reach

"Quercetin and allopurinol were firstly confirmed to suppress renal NLRP3 inflammasome activation characterized by down-regulation of the NLRP3 and therefore reduction of Caspase 1 in STZ treated rats."

22701621

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➶

reach

"Recent studies [XREF_BIBR, XREF_BIBR] have demonstrated that quercetin could impair NLRP3 inflammasome activation to improve renal inflammation."

25298963

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➶

reach

"The purpose of the present study was then to determine if the NLRP3 inflammasome was activated with the exacerbated production of IL-1beta and IL-18 in the kidney of STZ induced diabetic rats associated with high urate level and lipid metabolism abnormality, and conversely, if quercetin and allopurinol inhibited renal NLRP3 inflammasome activation involved in their actions on hyperuricemia and lipid metabolism disorder in this model."

22701621

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➶

reach

"The current study proved for the first time that quercetin treatment remarkably inhibited hypothalamic NLRP3 and caspase-1 in high fructose fed rats, being consistent with the reduction of hypothalamic TXNIP overexpression."

24491314

---

➶

reach

"Quercetin inhibits constitutively active NLRP3 inflammasome."

28148962

---

➶

reach

"Similarly, quercetin also inhibited cholesterol crystal induced NLRP3 inflammasome activation."

28148962

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➶

reach

"Together, these results suggest that the inhibition of hypothalamic AMPK and TXNIP dysregulation and NF-kappaB pathway and NLRP3 inflammasome activation by quercetin may reduce hypothalamic inflammation in high fructose fed rats."

24491314

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➶

reach

"Quercetin inhibits NLRP3 and AIM2 inflammasome activation."

28148962

---

➶

reach

"Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury."

26754474

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➶

reach

"Since quercetin inhibited both the NLRP3 and AIM2 inflammasome, but not the NLRC4 inflammasome, we hypothesized that quercetin inhibition might be through the adaptor protein ASC."

28148962

---

➶

reach

"Since quercetin was able to inhibit both the NLRP3 and AIM2 inflammasomes, we investigated if this flavonoid could also inhibit the NLRC4 inflammasome."

28148962

---

➶

reach

"Quercetin suppresses NLRP3 inflammasome activation in epithelial cells triggered by Escherichia coli O157 : H7."

28476502

---

➶

reach

"Quercetin administration significantly decreased reactive oxygen species production, inhibited NLRP3 inflammasome activation and reduced inflammatory cytokine levels."

26754474

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➶

reach

"In a study, using streptozotocin- (STZ-) induced diabetic nephropathy rat model leading to hyperuricemia and dyslipidemia, quercetin was found to block NLRP3 inflammasome activation [XREF_BIBR]."

27672241

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➶

reach

"Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH induced liver injury via regulating SIRT1 pathway."

32492628

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➶

reach

"We found that both ATP and nigericin (inducers of mitochondrial dysfunction and K + efflux), as well as alum (lysosomal damage) induced NLRP3 inflammasome activation were inhibited by quercetin."

28148962

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➶

reach

"Furthermore, quercetin and allopurinol were found to suppress renal NLRP3 inflammasome activation, at least partly, via their anti-hyperuricemic and anti-dyslipidemic effects, resulting in the amelioration of STZ induced the superimposed nephrotoxicity in rats."

22701621

Phenethyl caffeate affects NLRP3

| 1 17

Phenethyl caffeate inhibits NLRP3. 18 / 18

| 1 17

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➶

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"Moreover, CAPE significantly inhibited the formation of ASC dimers and reduced the abundance of NLRP3 inflammasome complexes in a dose dependent manner (XREF_FIG)."

32435622

---

➶

reach

"We examined whether CAPE could suppress uric acid crystals induced NLRP3 inflammasome activation in gout."

27934918

---

➶

reach

"We investigated the mechanism by which CAPE suppresses NLRP3 inflammasome activation."

27934918

---

➶

reach

"Co-immunoprecipitation study showed that CAPE prevented MSU induced association of NLRP3 and ASC in BMDMs (XREF_FIG)."

27934918

---

➶

reach

"CAPE Decreases NLRP3 Inflammasome Activation in BMDMs and THP-1 Cells."

32435622

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➶

sparser

"In conclusion, CAC can be prevented by CAPE-induced NLRP3 inflammasome inhibition, highlighting CAPE as a potential candidate for reducing the risk of CAC in patients with inflammatory bowel disease."

32435622

---

➶

reach

"These results show that CAPE suppresses NLRP3 inflammasome activation mediated by other activators, such as ATP and nigericin in macrophages."

27934918

---

➶

reach

"Therefore, we examined whether CAPE could inhibit NLRP3 inflammasome activation mediated by other activators, such as ATP and nigericin."

27934918

---

➶

reach

"We first investigated whether CAPE inhibits the activation of NLRP3 inflammasome induced by ATP and LPS in macrophages in vitro."

32435622

---

➶

reach

"In conclusion, CAC can be prevented by CAPE induced NLRP3 inflammasome inhibition, highlighting CAPE as a potential candidate for reducing the risk of CAC in patients with inflammatory bowel disease."

32435622

---

➶

reach

"CAPE suppresses uric acid crystal induced NLRP3 inflammasome activation in bone marrow derived primary macrophages."

27934918

---

➶

reach

"These results suggest that CAPE suppresses the activation of the NLRP3 inflammasome by directly binding ASC, blocking the association of NLRP3 and ASC."

27934918

---

➶

reach

"Overall, the results indicate that activated NLRP3 in AOM and DSS mouse model is suppressed by CAPE."

32435622

---

➶

reach

"We first investigated whether CAPE could block the activation of NLRP3 inflammasome induced by uric acid crystals."

27934918

---

➶

reach

"To determine whether CAPE inhibits NLRP3 inflammasome in vivo, we assessed NLRP3 expression in the AOM and DSS mouse model by immunohistochemistry and western blotting."

32435622

---

➶

reach

"The results show that CAPE suppressed the activation of NLRP3 inflammasome in murine macrophages and human monocytic cells."

27934918

---

➶

reach

"In primary mouse macrophages, caffeic acid phenethyl ester (CAPE) blocked caspase-1 activation and IL-1beta production induced by MSU crystals, showing that CAPE suppresses NLRP3 inflammasome activation."

27934918

---

➶

reach

"We found that CAPE decreased NLRP3 inflammasome activation in BMDMs and THP-1 cells and protected mice from colorectal cancer induced by AOM and DSS."

32435622

(-)-epigallocatechin 3-gallate affects DDX58

| 1 17

(-)-epigallocatechin 3-gallate inhibits DDX58. 18 / 18

| 1 17

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➶

reach

"While these studies provide several features for the interaction, additional studies will be required to elucidate of the mechanism (s) through which EGCG inhibits RIG-I signaling."

20877565

---

➶

sparser

"EGCG inhibited poly(I∶C)-dependent signaling of RIG-I K270A mutant to the same level as the wild type ( xref )."

20877565

---

➶

reach

"Interestingly, EGCG did not inhibit the constitutive signaling activity of RIG-I (XREF_FIG)."

20877565

---

➶

reach

"These results show that EGCG could inhibit RIG-I after RNA binding, although it does n't inform us as to whether RNA remains bound after EGCG binding."

20877565

---

➶

reach

"EGCG at 2 microM reduced RIG-I signaling induced by 10 nM RNA."

20877565

---

➶

reach

"Furthermore, EGCG dose-dependently inhibited the ATPase activity of recombinant RIG-I but did not compete with RIG-I interaction with RNA or with ATP."

20877565

---

➶

reach

"Furthermore, EGCG did not inhibit the constitutive activities of RIG-I deletion mutants R-C and R-CH (XREF_FIG)."

20877565

---

➶

reach

"At 2 microM, EGCG, its epimer GCG, and the digallate TFDG reduced RIG-I signaling by more than 60% (XREF_FIG)."

20877565

---

➶

reach

"EGCG reduced RIG-I signaling at all concentrations of the transfected RIG-I plasmid tested (XREF_FIG)."

20877565

---

➶

reach

"However, 1 microM of EGCG inhibited the ATPase activity of RIG-I to 30% in the presence of 2 mM ATP, suggesting that EGCG does not interfere with ATP binding site or acts on portions of RIG-I in addition to the ATP binding site."

20877565

---

➶

reach

"Lastly, the green tea molecule EGCG has also been shown to inhibit the ATPase function of RIG-I (334)."

31379819

---

➶

reach

"EGCG inhibited shR9 dependent RIG-I signaling in a concentration dependent manner, with an IC 50 between 1 to 2 microM in the cell based reporter assay (XREF_FIG)."

20877565

---

➶

reach

"We demonstrate that treatment with EGCG, in the absence of a viral infection, increased the mRNA expression levels of RIG-I, which appear to be in contrast to a recent study which showed that EGCG suppresses Rig-I signaling [58] ."

21549835

---

➶

reach

"The identification of EGCG inhibition of RIG-I activity provides proof of principle for small molecule modulators of this target."

20877565

---

➶

reach

"EGCG inhibits RIG-I signaling."

20877565

---

➶

reach

"Increasing the concentration of recombinant RIG-I protein in the presence of constant amount of EGCG and shR9 reduced the inhibitory effect of EGCG, likely by titrating away EGCG (XREF_SUPPLEMENTARY)."

20877565

---

➶

reach

"The time of addition experiment suggested that EGCG could inhibit RIG-I only after agonist binding and EGCG did not compete with RNA binding (XREF_FIG)."

20877565

---

➶

reach

"EGCG inhibited RIG-I signaling in a cell based reporter assay and RNA dependent ATPase activity of recombinant RIG-I protein in biochemical assays."

20877565

Resveratrol affects RELA

12 | 5

Resveratrol inhibits RELA. 17 / 17

12 | 5

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➶

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"Moreover, resveratrol treatment significantly reduced eosinophil counts, p65, Interferon-gamma, interleukin (IL)-5, IL-33, and tumor necrosis factor-alpha levels, matrix metalloproteinase-9 activity, claudin-5 degradation, and blood-brain barrier permeability."

28545897

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➶

ctd

No evidence text available

22246136

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➶

reach

"Resveratrol reduced the transcriptional activity of p65, but neither affected the DNA binding activity of NF-kappaB nor blocked the nuclear translocation of p65."

24020126

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➶

ctd

No evidence text available

19047049

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➶

ctd

No evidence text available

11858183

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➶

ctd

No evidence text available

22363816

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➶

ctd

No evidence text available

21239502

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➶

ctd

No evidence text available

19284563

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➶

reach

"The results showed that resveratrol, the activator of SIRT1, inhibited the binding of NF-kappaB p65 to the MMP-13 promoter, and the situation was the opposite after being treated with the inhibitor of SIRT1."

28473882

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➶

ctd

No evidence text available

17938187

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➶

reach

"Furthermore, resveratrol also inhibited the appearance of subunit p65 in the nucleus [XREF_BIBR]."

27834913

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➶

ctd

No evidence text available

20675566

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➶

ctd

No evidence text available

17164350

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➶

ctd

No evidence text available

16490592

---

➶

ctd

No evidence text available

24020126

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➶

ctd

No evidence text available

18222423

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➶

reach

"To our knowledge, this study is the first to reveal that resveratrol targeting protein NQO2 plays a mediating role in resveratrol induced changes of NF-kappaB p65, which may contribute to the anti-CaP activities elicited by resveratrol."

19661309

Minocycline affects CASP1

2 | 3 12

Minocycline inhibits CASP1. 17 / 17

2 | 3 12

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➶

reach

"The same group found that minocycline inhibits caspase-1, caspase-3, and iNOS activities in HD animals and observed a reduction in both disease progression and mortality of R6/2 animals [XREF_BIBR]."

22944909

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➶

reach

"Minocycline reduces traumatic brain injury mediated caspase-1 activation, tissue damage, and neurological dysfunction."

11383749

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➶

sparser

"For example, treatment of mice that overexpress a mutant huntingtin transgene with minocycline, which inhibits both caspases-1 and -3, delays the death of the animals [20] ."

11943195

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➶

reach

"After ischemia, minocycline inhibits caspase-1 and inducible nitric oxide synthetase upregulation, and reduces infarction."

10888929

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➶

reach

"Furthermore, it was reported that mice lacking caspase 1 or treatment of wild-type mice with a semisynthetic antibiotic minocycline, which potentially functions to inhibit caspase 1 and modulates the gut microbiota, are protected from developing depressive-like and anxiety-like behaviours, even when experiencing chronic stress253."

30185915

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➶

reach

"At 2 months of diabetes, minocycline inhibited hyperglycemia induced caspase-1 activity and IL-1beta production in the retina."

17192486

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➶

sparser

"After ischemia, minocycline inhibits caspase-1 and inducible nitric oxide synthetase upregulation, and reduces infarction."

10888929

---

➶

reach

"Minocycline, a tetracycline-derivative antibiotic, which can bind to the 30S ribosome in prokaryotes and inhibit translation, has been also shown to inhibit caspase-1 activation in R6/2 mice, while tetracycline has no effect."

22967354

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➶

reach

"Minocycline was also able to suppress the activation of caspase-1 XREF_BIBR."

22848638

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➶

ctd

No evidence text available

15159491

---

➶

reach

"Minocycline, a tetracycline antibiotic with high CNS penetration when taken orally, inhibits caspase-1 and caspase-3 enzymes and decreases activity of inducible nitric oxide synthase [53]."

12020475

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➶

reach

"We report that minocycline delays disease progression, inhibits caspase-1 and caspase-3 mRNA upregulation, and decreases inducible nitric oxide synthetase activity."

10888929

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➶

sparser

"Caspase 1 inhibition by minocycline slows degeneration and disease progression in mouse models of HD [ xref ]."

25873774

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➶

reach

"Caspase 1 inhibition by minocycline slows degeneration and disease progression in mouse models of HD [XREF_BIBR]."

25873774

---

➶

reach

"Isatin sulfonamides have been described as potent and selective non peptidic caspase-3 and -7 inhibitors [58], but no development has as yet been reported.The second generation tetracycline antibiotic minocycline, sometimes referred to as a caspase inhibitor, reduces caspase-1 and -3 activities, presumably by interfering with the upstream activation of these enzymes."

14980539

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➶

ctd

No evidence text available

12930891

---

➶

reach

"Minocycline inhibits caspase-1 and caspase-3, which are involved in the generation of interleukin-1 and the induction of apoptosis, respectively."

21716954

Lipopolysaccharide affects IRF3

| 17

Lipopolysaccharide inhibits IRF3. 17 / 17

| 17

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➶

reach

"Interestingly, LPS, which was simply used as a control for activation of NFkB, appeared to repress IRF3 signaling in combination with 2 ' 3 '-cGAMP (XREF_FIG)."

29553248

---

➶

reach

"Furthermore, LPS mediated activation of IRF-3 in RAW264.7 cells was also decreased by G-Rc in our reporter assay (XREF_FIG B)."

28413316

---

➶

reach

"Silencing MIB1 or MIB1 plus MIB2 selectively inhibited Sendai mediated IRF3 phosphorylation but had little effect on HSV- and LPS driven IRF3 activation in MEFs (XREF_FIG)."

21903422

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➶

reach

"Consistent with previous reports [19,30], IP-10 and IL-15 mRNA induction was dramatically decreased in LPS stimulated IRF-3 -/- DCs."

12821121

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➶

reach

"In addition, in cells deficient for the TBK1 gene, the dsRNA-or LPS mediated activation of IRF3 and induction of IRF3 dependent genes such as interferon beta and IP-10 were considerably reduced whereas induction of inflammatory cytokines, which is regulated by the MyD88 dependent pathway and activation of NFkappaB and MAP kinases, was not impaired [15]."

16199137

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➶

reach

"ILG inhibited interferon regulatory factor 3 activation induced by LPS or polyinosinic-polycytidylic acid, as well as interferon inducible genes, such as interferon inducible protein-10."

20356041

---

➶

reach

"LPS induced IRF3 activation is repressed in the absence of CLIC4, but enhanced when CLIC4 is overexpressed."

21469130

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➶

reach

"In apparent contradiction to these observations, Pitha 's group reported that LPS inhibits the virus mediated activation of IRF-3 [46]."

12213596

---

➶

reach

"The inactive isomers of opioid receptor antagonists (+)-naltrexone and (+)-naloxonea act as TLR4 antagonists and inhibit LPS induced IRF-3 activation and subsequent IFN production."

27468646

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➶

reach

"TMED7 overexpression inhibits the ability of TRAM, an adaptor utilized by toll like receptor 4, or lipopolysaccharide to activate the interferon regulatory factor 3 signalling pathway, whereas TMED7 knockdown enhances production of the cytokine, RANTES, following lipopolysaccharide stimulation."

22426228

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➶

reach

"To investigate the potency of TBK1 and IKKi kinase inhibition of these new compounds in living cells, we tested whether LPS induced activation of IRF3 in macrophages can be blocked by the treatment of these compounds XREF_BIBR, XREF_BIBR."

24150799

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➶

reach

"Rab11a knockdown gave a marked inhibition of E. coli - and LPS induced signaling to IRF3, whereas NF-kappaB activation was unaffected."

20933442

---

➶

reach

"TAG inhibited activation of IRF3 by lipopolysaccharide."

19412184

---

➶

reach

"Inhibition of lipopolysaccharide induced interferon regulatory factor 3 activation and protection from septic shock by hydroxystilbenes."

15087825

---

➶

reach

"Rottlerin reduced mA3 mRNA induction by IFNalpha but not LPS in the absence of IRF3 (XREF_FIG)."

22972924

---

➶

reach

"On the other hand, LPS treatment down-regulated IRF3, TBK1 and TRIF in 4F treated MDMs compared to vehicle pre-treatment."

22982462

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➶

reach

"The inhibitory effect on LPS induced IRF3 activation by CAPE was not observed when 293T cells were reconstituted with MD2 (C133S) mutant."

23231684

(-)-epigallocatechin 3-gallate affects JUN

| 1 2 14

(-)-epigallocatechin 3-gallate inhibits JUN. 17 / 17

| 1 2 14

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➶

reach

"EGCG also abrogated the nicotine induced activation of AP-1 subunits c-fos and c-jun."

23835612

---

➶

reach

"EGCG inhibits AP-1, JNK, c-Jun and cyclinD1 which are key targets on AP-1 signal transduction pathway."

15355641

---

➶

reach

"Recently, EGCG has been shown to inhibit MAP kinase pathway and activator protein-1 (AP-1) activity in human colon cancer cells."

21827739

---

➶

reach

"EGCG could also inactivate c-Jun, NF-kappaB, ERK1/2, and p38 signaling, resulting in decreased expression of MMP-2 and MMP-9 in PCa cells [XREF_BIBR]."

24375392

---

➶

reach

"The binding of EGCG with Arg17 in the WW domain prevented the binding of c-Jun, a well-known Pin1 substrate."

21750208

---

➶

reach

"Further experiments demonstrated that EGCG reduced the transcriptional activity of activator protein-1 (AP-1) and nuclear factor kappaB (NF-kappaB), two important nuclear transcription factors that are involved in MMP-9 expression."

15708369

---

➶

reach

"In particular, EGCG inhibited tumor promoter induced activator protein-1, signal transducers and activators of transcription, phosphatidylinositol 3-kinase/Akt, and nuclear factor-kappaB activation."

19470792

---

➶

reach

"Reporter assays indicated that both EGCG and Poly E inhibited the transcriptional activity of the activator protein 1 (AP-1), c-fos, nuclear factor kappaB, and cyclin D1 promoters."

15814656

---

➶

reach

"EGCG inhibits nuclear factor-kbeta and activator protein 1 in dermal fibroblasts."

25593422

---

➶

reach

"EGCG decreased transcription activity of Jun protein after induction by UVA."

15603715

---

➶

medscan

"The binding of epigallocatechin-3-gallate with Arg17 in the WW domain prevented the binding of c-Jun, a well-known Pin1 substrate."

21750208

---

➶

reach

"EGCG inhibited transcription factor AP-1, binding to DNA."

29472815

---

➶

sparser

"EGCG inhibits AP-1, JNK, c-Jun and cyclinD1 which are key targets on AP-1 signal transduction pathway."

15355641

---

➶

reach

"At the same dose range that inhibited cell transformation, EGCG and theaflavins inhibited activator protein-1 (AP-1) activation."

11216482

---

➶

sparser

"EGCG inhibits nuclear factor-kβ and activator protein 1 in dermal fibroblasts."

25593422

---

➶

reach

"EGCG has been shown to inhibit NF-kappaB activity, MAPK pathway, activator protein-1 (AP-1) activity, and EGFR mediated downstream signaling pathways, etc.."

21295962

---

➶

reach

"These intermediate pathways are involved in transformation, differentiation, and cell proliferation but, more importantly, EGCg also inhibited activator protein 1 (AP-1) function which has been associated with invasive and metastatic characteristics of cancer cells [38]."

11853893

Tofacitinib citrate affects TYK2

16 |

Tofacitinib citrate inhibits TYK2. 16 / 16

16 |

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➶

tas

No evidence text available

19053756

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➶

tas

No evidence text available

23668484

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➶

tas

No evidence text available

21105711

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➶

tas

No evidence text available

21106455

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➶

tas

No evidence text available

24461299

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

24398382

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➶

tas

No evidence text available

23659214

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➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

29156136

---

➶

tas

No evidence text available

22591402

---

➶

tas

No evidence text available

26927423

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➶

tas

No evidence text available

23214979

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➶

tas

No evidence text available

18183025

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➶

tas

No evidence text available

29298069

---

➶

tas

No evidence text available

24417533

Sulfonylurea affects NLRP3

| 16

Sulfonylurea inhibits NLRP3. 16 / 16

| 16

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➶

reach

"Together, these results suggest that : (i) the NLRP3 inflammasome and local IL-1beta (+) F4/80 (+) Ly6C (+) macrophages as novel players in the pathogenesis of VCP associated myopathy; and (ii) identified the sulfonylurea MCC950 inhibitor of the NLRP3 inflammasome with promising therapeutic potential for the future treatment of patients with VCP associated myopathy."

27730320

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➶

reach

"NOD2 stimulation by systemic administration of muramyl dipeptide appears to be beneficial in mouse models of colitis.123 Glyburide (glibenclamide), a sulfonylurea drug for the treatment of type 2 diabetes, is known to inhibit ATP-sensitive K+ channels and thus can prevent NLRP3 inflammasome activation.124 Glyburide has been shown to prevent ventilator-induced lung injury in mice and delay endotoxin-induced lethality in mice, but it has not been applied for animal models of colitis.124, 125PRR signaling has significant roles in intestinal homeostasis, which is mainly composed of the maintenance of commensals."

23515136

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➶

reach

"Likewise, a sulfonylurea drug Glyburide which is widely used for the treatment of Diabetes type 2, was also shown to inhibit the NLRP3 inflammasome."

32574259

---

➶

reach

"Glyburide (glibenclamide), a sulfonylurea drug for the treatment of type 2 diabetes, is known to inhibit ATP sensitive K+ channels and thus can prevent NLRP3 inflammasome activation."

23515136

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➶

reach

"Glyburide (International Nonproprietary Name : glibenclamide), an antidiabetic sulfonylurea drug, inhibits NLRP3 inflammasome activation by several stimuli, without affecting the NLRC4 or NLRP1 inflammasomes [XREF_BIBR]."

25152324

---

➶

reach

"Glyburide, the most widely used sulfonylurea drug for type 2 diabetes in the US, inhibits the Nalp3 inflammasome."

22065079

---

➶

reach

"The mechanism by which sulfonylurea compounds inhibit NLRP3 activation is currently not understood."

27508077

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➶

reach

"However, unlike for CY-09, the molecular target and mechanism by which MCC950 and CRID3 and related sulfonylurea molecules inhibit the NLRP3 inflammasome remains enigmatic."

29061692

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➶

reach

"As evidence showed that another sulfonylurea drug glipizide also inhibited Sur1 containing K ATP channels but failed to inhibit NLRP3 inflammasome activation."

28740332

---

➶

reach

"The sulfonylurea Glyburide inhibits ATP sensitive K + (K ATP) channels and has been shown to inhibit NLRP3 inflammasome activation, without affecting the NLRP1 or NLRC4 inflammasomes."

26024799

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➶

reach

"Moreover, the present study identified the sulfonylurea MCC950 inhibitor of the NLRP3 inflammasome as a promising therapeutic drug for the treatment of VCP associated myopathy."

27730320

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➶

reach

"The sulfonylurea drug glyburide, usually used clinically to treat type II diabetes, is a non selective antagonist of NALP3 and could prevent activation of the NALP3 inflammasome and crystal induced IL-1beta secretion."

30186184

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➶

reach

"Finally, we treated monocytes and MDC with 100 muM glibenclamide, a sulfonylurea drug which inhibits NLRP3 activation but not NLRC4 activation [XREF_BIBR]."

28081233

---

➶

reach

"The results confirm that the NLRP3 inflammasome and local IL-1beta (+) F4/80 (+) Ly6C (+) macrophages as novel players in the pathogenesis of VCP associated myopathy and identified the sulfonylurea MCC950 inhibitor of the NLRP3 inflammasome with promising therapeutic potential for the treatment of VCP associated myopathy."

27730320

---

➶

reach

"Glyburide (glibenclamide), a sulfonylurea drug used for the treatment of type-2 diabetes, is known to inhibit ATP sensitive K + channels and can thus prevent NLRP3 inflammasome activation."

26279628

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➶

reach

"Furthermore, inhibition of NLRP3 inflammasome by glybenclamide, a sulfonylurea inhibitor of NLRP3 inflammasome, was found to be able to suppress microglial proinflammatory activation and nuclear factor-kappaB activation induced by paraquat and maneb."

32375810

Methylene blue affects NLRP3

| 1 15

Methylene blue inhibits NLRP3. 16 / 16

| 1 15

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➶

reach

"We have only indirect evidence MB indeed inhibits NLRP3 activity in vivo."

30101125

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➶

reach

"Specifically, MB blocks the NLRP3, NLRC4, and AIM2 inflammasomes as well as non canonical inflammasome."

28963531

---

➶

reach

"This result suggests that MB inhibits NLRP3 inflammasome activation as well as the priming step."

28963531

---

➶

reach

"These data suggest that MB inhibited assembly of the NLRP3 inflammasome, which is upstream of caspase-1, IL-1beta, and IL-18 maturation."

28963531

---

➶

reach

"Methylene blue inhibits NLRP3 inflammasome activation."

28963531

---

➶

reach

"HIGHLIGHTS - Cytogenetic abnormalities and innate immune activation are seen in myelodysplasia- The NLRP3 inflammasome is a core element generating marrow failure of myelodysplasia- In April 2018 methylene blue was reported to potently inhibit NLRP3 inflammasome function- Methylene blue has benign side effects and has been in human use for a century- Study of methylene blue treatment of myelodysplasia would be a low-risk intervention."

30101125

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➶

reach

"In the present study, we demonstrated that MB treatment blocked the priming step of inflammasome activation as well as up-regulation of pro-IL-1beta and NLRP3 proteins XREF_BIBR, XREF_BIBR."

28963531

---

➶

reach

"HIGHLIGHTS - Cytogenetic abnormalities and innate immune activation are seen in myelodysplasia - The NLRP3 inflammasome is a core element generating marrow failure of myelodysplasia - In April 2018 methylene blue was reported to potently inhibit NLRP3 inflammasome function - Methylene blue has benign side effects and has been in human use for a century - Study of methylene blue treatment of myelodysplasia would be a low-risk intervention Introduction -- myelodysplasia."

30101125

---

➶

reach

"Of central importance to MDS, three recent independent studies showed that MB inhibits NLRP3 inflammasome function."

30101125

---

➶

reach

"Lin et al. showed that MB inhibited murine cord transection initiated NLRP3 activation."

30101125

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➶

reach

"In the same study it was demonstrated that MB downregulates ROS, NFB, and NLRP 3 by the antioxidant effect which reduces NFkB and NLRP 3 proteins expression by ROS and NF-KB-NLRP 3 pathway."

32326607

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➶

eidos

"In the same study it was demonstrated that MB downregulates ROS , NFB , and NLRP3 by the antioxidant effect which reduces NFkB and NLRP3 proteins expression by ROS / NF-KB-NLRP3 pathway ."

32326607

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➶

reach

"Methylene blue attenuates mitochondrial ROS production, phagocytosis, caspase 1 activity, and NLRP3 promoter activity."

28963531

---

➶

reach

"Methylene blue inhibits NLRP3, NLRC4, AIM2, and non canonical inflammasome activation."

28963531

---

➶

reach

"Ahn et al. showed that MB inhibited LPS stimulated increase in murine NLRP3 function."

30101125

---

➶

reach

"We showed that methylene blue can alleviate the apoptosis and inflammatory response induced by renal IR injury in mice, and its relevant mechanism may be related to the fact that methylene blue can negatively regulate NLRP3 signaling pathway."

29771438

Curcumin affects IKBKB

3 | 2 11

Curcumin inhibits IKBKB. 16 / 16

3 | 2 11

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➶

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"Curcumin (10 muM) markedly inhibited IKK1 and IKK2 activity induced by LPS, whereas tetrahydrocurcumin (4H), hexahydrocurcumin (6H), and octahydrocurcumin (8H) showed a less inhibitory effect at the same concentration."

11077049

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➶

reach

"Curcumin inhibited IKKbeta in the cytoplasm and nucleus, leading to reduced NFkappaB activity, with no effect on pAKT."

20937593

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➶

reach

"Our data also showed that curcumin inhibited the expression of several important proteins regulated by NF-kappaB; in particular, we demonstrated that there is a reduced expression of IKKalpha and IKKbeta in tumor of mice treated with curcumin with respect to controls, indicating that curcumin inhibits NF-kappaB activation through suppression of IKK in MIA PaCa-2 cells."

24324975

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➶

reach

"Curcumin, the yellow pigment derived from Curcuma longa, inhibited IKKalpha, IKKbeta and NIK, indicating its strong potential to block NF-kappaB-mediated cytokine release and the innate immune response."

15927892

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➶

reach

"Curcumin inhibited IKKbeta in the cytoplasm and nucleus, leading to reduced NFkappaB activity, with no effect on phospho-AKT."

20937593

---

➶

ctd

No evidence text available

16023083

---

➶

reach

"Inhibition of IKKbeta by curcumin therefore results in reduction in NFkB occupied sites in chromatin leading to a decrease in NFkB mediated transcription."

20937593

---

➶

reach

"The inhibition of DeltaTLR4 induced NF-kappaB activation by curcumin may be due to the inhibition of IKKbeta by curcumin; thus, this inhibition may not be a specific readout for the inhibition of ligand independent dimerization of DeltaTLR4."

16678799

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➶

ctd

No evidence text available

16678799

---

➶

reach

"Our data indicated that there is a reduced expression of IKKalpha and IKKbeta in tumor of mice treated with curcumin with respect to controls, indicating that curcumin inhibits NF-kappaB activation through suppression of IKK (XREF_FIG)."

24324975

---

➶

medscan

"Our observation is in line with the recent studies showing that Curcumin, an antioxidant and anti-inflammatory substance derived from the East Indian plant Curcuma longa, inhibits IKKβ activity and suppresses cell proliferation as a single agent or in combination and cisplatin in head and neck squamous cell carcinoma [ - ]."

26895469

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➶

reach

"Curcumin with alpha,beta-unsaturated carbonyl group can react with SH group in cysteine in the activation loop of IKKbeta, and thereby can inhibit the kinase activity of IKKbeta."

16678799

---

➶

reach

"Curcumin can interact with the sulfhydryl group of cysteine in the activation loop of IKKbeta, thereby inhibiting the kinase activity of IKKbeta [22]."

20939996

---

➶

ctd

No evidence text available

16219905

---

➶

reach

"Our observation is in line with the recent studies showing that Curcumin, an antioxidant and anti-inflammatory substance derived from the East Indian plant Curcuma longa, inhibits IKKbeta activity and suppresses cell proliferation as a single agent or in combination and cisplatin in HNSCC [XREF_BIBR - XREF_BIBR]."

26895469

---

➶

medscan

"Curcumin inhibits NF-κB activation induced by lipopolysaccharide, phorbol 12-myristate 13-acetate, TNF-α, and hydrogen peroxide through the inhibition of IKKβ that phosphorylates IκBα, leading to ubiquitinylation and degradation ( ; )."

18413660

Celastrol affects CASP1

| 16

Celastrol inhibits CASP1. 16 / 16

| 16

---

➶

reach

"We found that pretreatment of celastrol effectively inhibited IL-1beta secretion and caspase-1 activation in BMDMs and BMDCs."

28978034

---

➶

reach

"Consistently, celastrol dose-dependently suppressed caspase-1 activation and IL-1beta maturation, but no effects on pro-IL-1beta and pro-caspase-1 expression."

28978034

---

➶

reach

"Similarly, the caspase-1 cleavage and IL-1beta secretion were also suppressed by celastrol after stimulation with different TLR."

28978034

---

➶

reach

"Furthermore, we observed that gambogic acid and celastrol inhibit caspase-1 and NF-kB activation."

| PMC

---

➶

reach

"Interestingly, we observed that celastrol inhibited caspase-1 cleavage and IL-1beta secretion, suggesting that celastrol effectively inhibited both LPS induced priming and inflammasome activation under different conditions (XREF_SUPPLEMENTARY)."

28978034

---

➶

reach

"To assess the effect of celastrol on NLRP3 inflammasome activation, we first examined whether celastrol could inhibit caspase-1 cleavage and IL-1beta secretion."

28978034

---

➶

reach

"Celastrol significantly suppresses inflammation by reducing the secretion of IL-1beta and IL-18, and inactivating the NLRP3 inflammasomes and caspase-1 in LPS and ATP primed macrophage cells."

29491837

---

➶

reach

"Moreover, celastrol treatment markedly decreased mRNA expression caspase-1, NLRP3 and ASC in colon tissue."

28978034

---

➶

reach

"Also in this case, celastrol administration decreased the activation of caspase-1 (XREF_FIG)."

22415021

---

➶

reach

"We performed these NLRP3 agonists and found that celastrol also inhibited IL-1beta secretion and caspase-1 activation, but did not affect the secretion of TNF-alpha or IL-6 and the expression of pro-IL-1beta and pro-caspase-1, suggesting that celastrol is a potent and broad inhibitor of NLRP3 inflammasome."

28978034

---

➶

reach

"Celastrol suppresses IL-1beta secretion and caspase-1 activation in mouse macrophages."

28978034

---

➶

reach

"Celastrol inhibits the activation of NF-kB and caspase-1."

22415021

---

➶

reach

"In addition, celastrol treatment dramatically decreased caspase-1 cleavage in macrophages from DSS fed mice."

28978034

---

➶

reach

"Taken together, these data indicate that celastrol inhibits NLRP3 inflammasome mediated IL-1beta secretion and caspase-1 activation in both mice and human myeloid cells."

28978034

---

➶

reach

"To further confirm that celastrol could inhibit caspase-1 activation, cell lysates from celastrol treated LPS primed macrophages was reacted with recombinant active caspase-1."

28978034

---

➶

reach

"We can thus conclude that celastrol inhibits NF-kB and caspase-1 activation."

22415021

Capsaicin affects ITCH

| 16

Capsaicin inhibits ITCH. 16 / 16

| 16

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➶

reach

"Repeated application of topical capsaicin causes depletion of SP from sensory nerve endings and abolishes pain and itch (Fitzgerald, 1983; Wallengren and Moller, 1986; Lynn, 1992)."

11553396

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➶

reach

"Capsaicin pretreatment reduced peak itch responses to histamine and cowhage after 24-h pretreatment to 1.41 +/- 0.58 (P = 0.003) and 0.81 +/- 0.18, (P < 0.001), respectively."

28117875

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➶

reach

"Capsaicin pretreatment for 1 h reduced only cowhage induced itch (P = 0.023)."

28117875

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➶

reach

"In addition, creams containing local anesthetics [XREF_BIBR], capsaicin, doxepin [XREF_BIBR], strontium nitrate [XREF_BIBR], or nedocromil sodium [XREF_BIBR] can be helpful to relieve itch."

26064156

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➶

reach

"However, it should also be noted that repeated and prolonged applications of topical capsaicin are required to effectively reduce itch [XREF_BIBR, XREF_BIBR]."

18667087

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➶

reach

"The topical capsaicin robustly, and with similar efficaciousness, inhibited itch intensity evoked by electrical stimulation and histamine (-89+/-4.1% and -78 +/-4.9%, respectively, both : P < 0.0001 compared to the placebo patch area)."

29421065

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➶

reach

"Our data show that histamine itch is mediated by TRPV1 + fibers that do not express appreciable levels of TRPA1, since histamine itch is inhibited by silencing capsaicin activated fibers, but not by silencing AITC activated fibers."

23685721

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➶

reach

"With repeated topical applications, capsaicin not only reduces the magnitude of chemically evoked itch and nociceptive sensations [XREF_BIBR] but also attenuates the itch mediated by an intradermal injection of histamine and abolishes the itch elicited by cowhage [XREF_BIBR]."

19423224

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➶

reach

"In control subjects, capsaicin pretreatment significantly reduced itch sensations compared with nonpretreated skin, whereas in AE patients no differences were seen."

9705161

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➶

reach

"However, histamine itch can be abolished in human by capsaicin desensitization of the skin XREF_BIBR, XREF_BIBR and histamine itch is mediated through TRPV1 XREF_BIBR, XREF_BIBR."

24947823

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➶

reach

"To ablate the TRPV1- and TRPV1- and TRPA1-positive sensory neurons, we used the super potent capsaicin analogue resiniferatoxin (RTX), which has been shown to suppress acute pain and itch in animal models via axonopathy."

28745101

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➶

reach

"To further explore this possibility, we asked if capsaicin can suppress itch evoked by alpha-Me-5-HT, a potent pruritogenic compound (XREF_FIG) that acts through capsaicin sensitive neurons."

21040853

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➶

reach

"Itch evoked by cowhage or histamine is reduced or blocked by capsaicin desensitization, suggesting that pruriceptive neurons are capsaicin sensitive."

19423224

---

➶

reach

"Topical capsaicin 8% pretreatment for 24 h reduced histaminergic and nonhistaminergic itch by about 75%, while a significant reduction (= ~ 60%) was achieved for only nonhistaminergic itch in a standard 1-h treatment."

28117875

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➶

reach

"Capsaicin suppressed completely itch in all patients."

10789077

---

➶

reach

"Capsaicin induced muscle pain reduced itch sensation significantly."

15109968

Amlexanox affects TBK1

| 3 1 12

Amlexanox inhibits TBK1. 16 / 16

| 3 1 12

---

➶

eidos

"Our study provides evidence that TBK1 inhibition by amlexanox alleviates PQ-induced ALI and may be a new therapeutic strategy ."

32763286

---

➶

reach

"Amlexanox, a clinically approved small-molecule therapeutic presently used to treat allergic rhinitis, ulcer, and asthma, is an inhibitor of the noncanonical IkB kinase-epsilon (IKKepsilon) and TANK binding kinase 1 (TBK1)."

31697998

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➶

reach

"Inhibition of IKKepsilon or TBK1 (data not shown) by amlexanox was competitive for its substrate ATP (XREF_FIG), indicating that it interacts with the enzymes in the ATP binding site."

23396211

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➶

eidos

"Consistent with this view , global knockout of the cGAS-cGAMP-STING downstream target TBK1 ( 37 ) or IRF3 ( 38 ) , or pharmacological inhibition of IkappaB kinase epsilon ( IKKepsilon ) and TBK1 by amlexanox , reduced body weight , enhanced insulin sensitivity , and improved glucose tolerance in obese mice and in a subset of patients with type 2 diabetes ( 34,39 ) ."

31109939

---

➶

reach

"Our study provides evidence that TBK1 inhibition by amlexanox alleviates PQ induced ALI and may be a new therapeutic strategy."

32763286

---

➶

eidos

"Inhibition of TBK1 by amlexanox attenuates paraquat-induced acute lung injury ."

32763286

---

➶

reach

"Amlexanox, which is known to inhibit TBK1 and IKKepsilon selectively, is an approved drug for the treatment of bronchial asthma, allergic rhinitis, and conjunctivitis in Japan and elsewhere."

29951055

---

➶

reach

"Amlexanox is a specific inhibitor of IKKepsilon and TBK1."

23396211

---

➶

reach

"In vitro studies revealed that amlexanox blocks TBK1 as well [XREF_BIBR]."

30791439

---

➶

reach

"Consistent with this view, global knockout of the cGAS-cGAMP-STING downstream target TBK1 or IRF3, or pharmacological inhibition of IkappaB kinase epsilon (IKKepsilon) and TBK1 by amlexanox, reduced body weight, enhanced insulin sensitivity, and improved glucose tolerance in obese mice and in a subset of patients with type 2 diabetes."

31109939

---

➶

reach

"Recently, amlexanox has been shown to inhibit TBK1 and IKKepsilon, both of which are induced in the liver and fat by high-fat diet mediated NF-kappaB activation [XREF_BIBR]."

27353409

---

➶

reach

"Amlexanox blocks activity of TBK1 and IKKepsilon with a half maximal inhibitory concentration (IC50) of approximately 1-2 muM."

30791439

---

➶

trips

"Inhibition of TBK1 by amlexanox attenuates paraquat-induced acute lung injury."

32763286

---

➶

reach

"Amlexanox, an inhibitor of RLR signaling pathway, specifically supresses the noncanonical IkB kinases IKKε and TBK1, and both are essential players for the coordination of IFN regulatory factor 3 (IRF3)- and NF-κB-mediated innate immune response [27, 28]."

31562757

---

➶

reach

"Inhibition of TBK1 by amlexanox attenuates paraquat induced acute lung injury."

32763286

---

➶

reach

"Recently, Reilly et al. [XREF_BIBR] discovered a small molecule inhibitor of IKKepsilon and TBK1 kinases called amlexanox, which has been shown to selectively inhibit both IKKepsilon and TBK1."

27145266

VX-745 affects MAPK14

1 14 | 1

VX-745 inhibits MAPK14. 16 / 16

1 14 | 1

---

➶

tas

No evidence text available

15711537

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

16750367

---

➶

tas

No evidence text available

18325768

---

➶

tas

No evidence text available

19751974

---

➶

eidos

"During initial stages of the study , we verified that VX-745 potently and specifically inhibited p38alpha MAP kinase under our experimental conditions ."

32326654

---

➶

tas

No evidence text available

14667219

---

➶

tas

No evidence text available

24900264

---

➶

tas

No evidence text available

19950901

---

➶

tas

No evidence text available

23442188

---

➶

signor

"Vx-745 was reported to be active against several isotypes of p38 mapk, including p38alpha, p38beta and p38gamma"

11892915

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

23937569

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

16945533

TASOCITINIB affects TYK2

16 |

TASOCITINIB inhibits TYK2. 16 / 16

16 |

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➶

tas

No evidence text available

23659214

---

➶

tas

No evidence text available

29298069

---

➶

tas

No evidence text available

24417533

---

➶

tas

No evidence text available

24461299

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

21106455

---

➶

tas

No evidence text available

22591402

---

➶

tas

No evidence text available

29156136

---

➶

tas

No evidence text available

24398382

---

➶

tas

No evidence text available

23214979

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

19053756

---

➶

tas

No evidence text available

23668484

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

26927423

---

➶

tas

No evidence text available

21105711

Carnosol affects NLRP3

| 16

Carnosol inhibits NLRP3. 16 / 16

| 16

---

➶

reach

"These results suggested that carnosol blocks the activation of the NLRP3 and NLRC4 inflammasomes by binding to HSP90 and inhibiting its ATPase activity."

32312957

---

➶

reach

"Here, we report that carnosol inhibits NLRP3 inflammasome activation by directly targeting heat-shock protein 90 (HSP90), which is essential for NLRP3 inflammasome activity, thereby treating inflammasome mediated diseases."

32312957

---

➶

reach

"A high-throughput assay for bioluminescent caspase-1 activity in screening NLRP3 inflammasome inhibitors revealed that carnosol inhibits NLRP3 inflammasome activation (data not shown)."

32312957

---

➶

reach

"Consistent with the effect of GA, our results showed that carnosol also blocked NLRP3 and NLRC4, but not AIM2 inflammasome activation."

32312957

---

➶

reach

"Carnosol inhibits NLRP3 inflammasome activation in BMDMs, THP1 cells and hPBMCs."

32312957

---

➶

reach

"Taken together, these results demonstrate that carnosol treatment inhibits the activation of the NLRP3 inflammasome."

32312957

---

➶

reach

"Here, we report that carnosol inhibits NLRP3 inflammasome activation by directly targeting heat-shock protein 90 (HSP90), which is essential for NLRP3 inflammasome activity, thereby treating inflammasome mediated diseases."

32312957

---

➶

reach

"Taken together, these results showed that carnosol treatment disrupts the activation of NLRP3 inflammasome and NLRP3 related septic shock in mice."

32312957

---

➶

reach

"To test whether carnosol inhibits NLRP3 inflammasome activation in vivo, we chose the NLRP3 inflammasome dependent septic shock mouse model induced by intraperitoneal injection of LPS XREF_BIBR, XREF_BIBR."

32312957

---

➶

reach

"Our data demonstrate that carnosol inhibits NLRP3 inflammasome activation in primary mouse bone marrow derived macrophages (BMDMs), THP-1 cells and human peripheral blood mononuclear cells (hPBMCs)."

32312957

---

➶

reach

"In this study, we demonstrate that carnosol treatment inhibits NLRP3 inflammasome activation by directly interacting with HSP90 and blocking its ATPase activity."

32312957

---

➶

reach

"More importantly, carnosol treatment prevents or alleviates NLRP3 inflammasome mediated diseases in mouse models, indicating that carnosol is a potential candidate for the treatment of inflammasome mediated human diseases."

32312957

---

➶

reach

"Our data demonstrate that carnosol inhibits NLRP3 inflammasome activation in primary mouse bone marrow derived macrophages (BMDMs), THP-1 cells and human peripheral blood mononuclear cells (hPBMCs)."

32312957

---

➶

reach

"Thus, these results demonstrate that carnosol treatment inhibits NLRP3 and NLRC4 inflammasome activation by blocking HSP90 and disrupting its ATPase activity."

32312957

---

➶

reach

"We also demonstrated that carnosol can prevent or treat NLRP3 inflammasome driven human diseases, including septic shock and NASH in mouse models."

32312957

---

➶

reach

"Although the initial effective dose of carnosol needed to inhibit NLRP3 inflammasome activation was higher than that of MCC950 in vitro, the rescue effect of carnosol on inflammasome related diseases was comparable to that of MCC950 in all tested animal models of human diseases, suggesting that carnosol has a therapeutic potential equivalent to that of MCC950 for inflammasome mediated diseases."

32312957

ATP affects NLRP3

| 16

ATP inhibits NLRP3. 16 / 16

| 16

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➶

reach

"We found that the induction of IL-1beta secretion by nigericin or ATP was increased in BMDMs from TKO mice and PP2 pretreated THP-1 cells, suggesting that SFKs may suppress nigericin- or ATP induced NLRP3 inflammasome activation."

30382081

---

➶

reach

"SFN suppressed NLRP3 inflammasome activation induced by MSU crystals, adenosine triphosphate and nigericin but not by poly (dA : dT) in primary mouse macrophages, independent of the reactive oxygen species pathway."

29340626

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➶

reach

"We did not observe any significant decrease in ATP induced NLRP3 activation when monocytes were cotreated with UFAs."

25175736

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➶

reach

"In summary, activated CD4+ CD45RO+ memory T-cells suppress ATP triggered NLRP3 inflammasome activation in monocytes by the inhibition of P2X7R mediated signaling."

22768094

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➶

reach

"Collectively, these data revealed that Ro5-4864 was a potent drug for the reduction of IL-1beta and IL-18 release through suppression of ATP induced NLRP3 inflammasome activation in the representative immune cells.Adaptor protein ASC plays a critical role in the formation of the NLRP3 inflammasome."

27103438

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➶

reach

"Importantly, we have previously demonstrated that MSC reduce the CVB3 induced ROS production in cardiomyocytes 18, whereas Oh et al. 20 recently illustrated that MSC decrease mitochondrial ROS and inhibit LPS- and ATP induced NLRP3 inflammasome activation in macrophages primarily by secreting STC-1."

29434214

---

➶

reach

"To further determine the effect of CS on inhibiting ATP induced activation of NLRP3 inflammasome, we treated BMDMs with CS at either the priming or the activating step, respectively."

28415686

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➶

reach

"Proteolysis of the NLRP3 protein was not observed with heat killed Pg and inhibition of ECs protein synthesis with cycloheximide did not abolish the NLRP3 protein degradation induced by Pg infection in ATP pre-treated cells."

24583910

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➶

reach

"Disruption of glycolysis and decreased ATP production have been reported to activate the NLRP3 inflammasome, and the activation of NLRP3 has an important effect on the differentiation and function of innate immune cells, such as macrophages [XREF_BIBR, XREF_BIBR]."

28732079

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➶

reach

"Furthermore, ATP induced NLRP3 inflammasome activation is strongly inhibited when NLRP3 is ubiquitinated, or NLRP3 deubiquitination is blocked, which indicates that NLRP3 deubiquitination is an essential posttranslational protein modification for NLRP3 activation."

24054327

---

➶

reach

"We confirmed previously reported observations that pre-treatment of LPS primed myeloid cells with 2-APB prior to stimulation by nigericin (or ATP) completely suppresses all indices of the activated NLRP3 signaling cascade."

25762778

---

➶

reach

"The ATP induced NLRP3 inflammasome activation requires activation of the P2X 7 receptor in combination with the pannexin-1 channel and decreases intracellular potassium levels [XREF_BIBR, XREF_BIBR]."

22216838

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➶

reach

"In contrast, ATP stimulated IL-1beta production was completely suppressed in the same Asc -/- and Nlrp3 -/- Nlrc4 -/- BMDC preparations."

24078693

---

➶

reach

"Intracellular ATP Decrease Mediates NLRP3 Inflammasome Activation upon Nigericin and Crystal Stimulation."

26546608

---

➶

reach

"In addition, using ATP synthesis inhibitors, oligomycin and 2-deoxyglucose, it was observed that decreased ATP level induced NLRP3 activation and necrosis while increased ATP led to apoptosis."

29892295

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➶

reach

"Our present study demonstrated that KM inhibited LPS and ATP induced pyroptosis and the release of IL-1beta/18 in J774A.1 cells by inhibiting the activation of GSDMD and caspase-1 and the assembly of NLRP3 inflammasome."

30952097

(R)-lipoic acid affects IKBKB

| 6 10

(R)-lipoic acid inhibits IKBKB. 16 / 16

| 6 10

---

➶

reach

"To verify that LA can inhibit IKK2 in living cells, we tested the effect of LA on a constitutively active IKK2 mutant IKK2 (EE)-induced NF-kappaB-dependent gene expression."

20927568

---

➶

reach

"In the present study, we show that (1) LA, but not other tested antioxidants, inhibits NF-kappaB activation, (2) LA induced activation of the PI3-kinase and Akt pathway in HUVECs does not contribute to its effects on NF-kappaB inhibition, (3) inhibition of IKK2 by LA may represent an important mechanism by which it mediates inhibitory effects on NF-kappaB activation."

20927568

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➶

reach

"In transient co-transfection assays of a constitutively active mutant of IkappaB kinase-2 (IKK2), IKK2 (EE), and a NF-kappaB luciferase reporter construct, LA dose-dependently inhibited IKK2 (EE)-induced NF-kappaB activation in addition to inhibiting IKK activity in in vitro assays."

20927568

---

➶

reach

"XREF_FIG shows that LA inhibited IKK2 activity concentration-dependently, with a half maximal inhibitory concentration (IC 50) of 0.15 mM (95% CI : 0.09-0.25 mM)."

20927568

---

➶

reach

"Consistent with the effect on luciferase expression, LA inhibited IKK2 (EE)-induced cyclo-oxygenase-2 (COX2) expression, suggesting that IKK2 inhibition by LA may be a relevant mechanism that explains its antiinflammatory effects."

20927568

---

➶

reach

"Our data demonstrate that LA inhibited IKK2 in vitro, providing a potential molecular mechanism for the inhibitory effect of LA on NF-kappaB signaling."

20927568

---

➶

sparser

"Our data demonstrate that LA inhibited IKK2 in vitro, providing a potential molecular mechanism for the inhibitory effect of LA on NF- κ B signaling."

20927568

---

➶

reach

"LA inhibits IKK2."

20927568

---

➶

reach

"A plausible mechanism suggests that lipoic acid mediated induction of heat shock proteins and the subsequent inhibition of JNK and IKKbeta."

21297908

---

➶

sparser

"Given that I κ B α degradation is regulated by IKK2-dependent phosphorylation, we tested whether LA inhibits IKK2. xref shows that LA inhibited IKK2 activity concentration-dependently, with a half maximal inhibitory concentration (IC 50 ) of 0.15 mM (95% CI: 0.09–0.25 mM)."

20927568

---

➶

sparser

"Consistent with the effect on luciferase expression, LA inhibited IKK2(EE)-induced cyclo-oxygenase-2 (COX2) expression, suggesting that IKK2 inhibition by LA may be a relevant mechanism that explains its antiinflammatory effects."

20927568

---

➶

reach

"In addition, acute LA treatment induced HSPs in vitro in L6 muscle cells and prevented the activation of JNK and IKKbeta with stimulants such as anisomycin and TNF-alpha, respectively."

19179648

---

➶

sparser

"LA inhibits IKK2."

20927568

---

➶

sparser

"In the present study, we show that (1) LA, but not other tested antioxidants, inhibits NF- κ B activation, (2) LA-induced activation of the PI3-kinase/Akt pathway in HUVECs does not contribute to its effects on NF- κ B inhibition, (3) inhibition of IKK2 by LA may represent an important mechanism by which it mediates inhibitory effects on NF- κ B activation."

20927568

---

➶

reach

"Given that IkappaBalpha degradation is regulated by IKK2 dependent phosphorylation, we tested whether LA inhibits IKK2."

20927568

---

➶

sparser

"To verify that LA can inhibit IKK2 in living cells, we tested the effect of LA on a constitutively active IKK2 mutant IKK2(EE)-induced NF- κ B-dependent gene expression."

20927568

(-)-epigallocatechin 3-gallate affects RELA

| 4 12

(-)-epigallocatechin 3-gallate inhibits RELA. 16 / 16

| 4 12

---

➶

reach

"EGCG treatment sequesters the p65 subunit of transcription factor NF-kappaB in the cytoplasm and inhibits transcriptional activity of the NF-kappaB-driven promoter in response to CpG-ODN."

24971028

---

➶

medscan

"Treatment of A431 cells with epigallocatechin-3-gallate (10-40 microg/ml) resulted in dose-dependent inhibition of NF-kappa B/p65, induction of DNA breaks, cleavage of poly(ADP-ribose) polymerase (PARP) and morphological changes consistent with apoptosis."

14676829

---

➶

reach

"EGCG also inhibited the upregulation of nuclear factor-kappa B/p65 (NF-kappaB and p65), and induction of cyclooxygenase 2 and inducible nitric oxide synthase."

26198193

---

➶

reach

"Moreover, EGCG inhibited NF-kappaB p65 activity by modulating the cellular localization of p65 and decreasing the transcriptional regulation of NF-kappaB p65 on Twist1 expression."

25487615

---

➶

reach

"EGCG alone inhibited NF-kappaBp65 and p-c-Jun (Ser 73) effectively."

28532672

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➶

reach

"Taken together, these results suggest that EGCG reduced PCB 126 mediated induction of p65 and suppressed NF-kappaB signaling via preventing PCB 126 induced p65 nuclear translocation in endothelial cells."

26878794

---

➶

reach

"Moreover, EGCG inhibited the activation of NF-kappaB and p65, an upstream regulator of COX-2, in A375 melanoma cells, and treatment of cells with caffeic acid phenethyl ester, an inhibitor of NF-kappaB, also inhibited cell migration."

22022384

---

➶

reach

"XREF_BIBR Epigallocatechin-3-gallate (EGCG), a gallic acid ester of catechin, blocks the production of TNF-alpha, IFN-gamma, NF-kB, and p65, which reduces inflammation in the intestinal mucous membrane."

25349576

---

➶

reach

"Moreover, EGCG inhibited NF-kappaB p65 activity by modulating the cellular localization of p65 and decreasing the transcriptional regulation of NF-kappaB p65 on Twist1 expression."

25487615

---

➶

medscan

"Epigallocatechin-3-gallate inhibits cancer progression by attenuating NF-κB p65 activity, which is upregulated in cancer stem cells and plays an important role in epithelial-mesenchymal transition ."

25487615

---

➶

reach

"The TNF-alpha-mediated NF-kappaB (p65) increase in the nuclei was blocked by the treatment of EGCG (XREF_FIG)."

16100442

---

➶

reach

"EGCG was found to inhibit the activation of NF-kappaB and p65 in a dose dependent manner."

23474498

---

➶

medscan

"(-)-Epigallocatechin-3-gallate inhibits nasopharyngeal cancer stem cell self-renewal and migration and reverses the epithelial-mesenchymal transition via NF-κB p65 inactivation."

25487615

---

➶

reach

"Both erlotinib and EGCG or their combination failed to inhibit p65 and Bcl-2 in M4e cells (XREF_FIG)."

19470788

---

➶

medscan

"Moreover, Epigallocatechin-3-gallate inhibited NF-κB p65 activity by modulating the cellular localization of p65 and decreasing the transcriptional regulation of NF-κB p65 on Twist1 expression."

25487615

---

➶

reach

"EGCG inhibits the activation of NF-kappaB and p65 in a dose dependent manner."

22022384

Nitric oxide affects MAPK8

| 3 12

Nitric oxide inhibits MAPK8. 15 / 15

| 3 12

---

➶

reach

"Collectively, our data suggest that endogenous NO mediates the IFN-gamma-induced suppression of JNK1 activation in macrophage cells by means of a thiol-redox mechanism."

11121042

---

➶

reach

"23 NO donors can inhibit JNK1 via S nitrosylation at Cys116, leading to reduced JNK1 phosphorylation."

23492768

---

➶

reach

"Recently, Sarkar et al. [XREF_BIBR] demonstrated that NO could inhibit autophagy by S nitrosylating and thus inhibiting the activities of IKKbeta and JNK1, potent inducers of autophagy."

22899934

---

➶

reach

"Moreover, Sarkar et al. [XREF_BIBR] demonstrated that nitric oxide (NO), in contrast to ROS, inhibited JNK1 by S nitrosylation and subsequently suppressed autophagy in rat primary neurons."

23434668

---

➶

medscan

"Nitric oxide inhibits an interaction between JNK1 and c-Jun through nitrosylation."

17054907

---

➶

medscan

"Here, we show that disruption of an interaction between JNK and its substrate c-Jun is an important mechanism underlying the Nitric oxide-mediated inhibition of JNK signaling."

17054907

---

➶

reach

"In addition, NO has been reported to inhibit JNK1 activation in murine microglial cells and macrophages via S -nitrosation of cysteine 116 (Park et al., 2000)."

11698047

---

➶

reach

"Furthermore, NO does not induce MCL-1 protein degradation in the absence of Jnk1."

19768117

---

➶

reach

"Moreover, Sarkar et al. [XREF_BIBR] demonstrated that nitric oxide (NO), in contrast to ROS, inhibited JNK1 by S nitrosylation and subsequently suppressed autophagy in rat primary neurons."

23434668

---

➶

reach

"We previously showed that NO negatively regulates JNK1 by a thiol redox mechanism [58]."

17054907

---

➶

reach

"These data suggest that NO inhibits all three isoforms of JNKs (JNK1, JNK2, and JNK3) through a thiol redox mechanism."

17054907

---

➶

reach

"JNK1 activity is suppressed after nitrosylation on its Cys116 by nitric oxide generated after IFN- administration in macrophages 38."

28572685

---

➶

reach

"NO donors can inhibit JNK1 via S nitrosylation at C116, leading to reduced JNK1 phosphorylation."

21726807

---

➶

medscan

"Nitric oxide impairs autophagy by inhibiting the activity of S-nitrosylation substrates, JNK1, and IKKβ."

26356821

---

➶

reach

"These observations are supported by the results of Western blot showing significantly decreased p-JNK2 levels and a strong tendency to decreased p-JNK1 in cells treated with ionomycin and the NO donor."

22470386

2-(carbamoylamino)-5-(4-fluorophenyl)-3-thiophenecarboxamide affects IKBKB

4 | 2 9

2-(carbamoylamino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits IKBKB. 15 / 15

4 | 2 9

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➶

sparser

"Our results suggest that IKK2 inhibition by its specific inhibitor TPCA-1 is able to block laser-induced CNV through the IKK-NF-κB signaling pathway, and in turn, the transcription of its downstream target genes that promote neovascularization."

24489934

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➶

tas

No evidence text available

19285872

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➶

reach

"To determine if the rapid induction of apoptosis in macrophages and DC was NF-kappaB and IKK inhibition dependent and not an off-target effect of TAT-NBD, five additional NF-kappaB inhibitory compounds were tested : Compound A (CmpA) and TPCA-1, both of which inhibit IKKbeta; MG-132, which inhibits IkappaBalpha proteosomal degradation; and IKKiVII and Wedelolactone, which inhibit both IKKalpha and IKKbeta (see XREF_SUPPLEMENTARY)."

24406986

---

➶

reach

"However, StA-IFN-1 and -4 (XREF_FIG, XREF_FIG) behaved as expected and were further examined by comparing their activity to the inhibitors TPCA-1, which inhibits the IFN induction pathway component IKKbeta, 15 and ruxolitinib, which inhibits IFN signaling pathway component Jak1 16 (XREF_FIG, XREF_FIG)."

27358388

---

➶

tas

No evidence text available

21429745

---

➶

sparser

"Consistent with a previous report xref , IKK2 inhibition by TPCA-1 did not cause ARPE-19 cell death even with TNFα induction ( xref )."

24489934

---

➶

reach

"Although BMS and TPCA-1 are specific inhibitors of IKKbeta, they may have non target effects on TM expression."

25039491

---

➶

tas

No evidence text available

18088098

---

➶

tas

No evidence text available

19035792

---

➶

reach

"Consistent with a previous report XREF_BIBR, IKK2 inhibition by TPCA-1 did not cause ARPE-19 cell death even with TNFalpha induction (XREF_FIG)."

24489934

---

➶

reach

"The NF-kappaB inhibitor [5-(p-fluorophenyl)-2-ureido] thiophene-3-carboxamide (TPCA-1), which inhibits IKKbeta, the kinase of IkappaBalpha (inhibitory protein of NF-kappaB), was used to prevent iron overload stimulated NF-kappaB changes in ESCs."

25500022

---

➶

reach

"The sustained intracellular release of TPCA-1 enabled prolonged inhibition of IKKbeta and competitively inhibited TNF-alpha from activating NF-kappaB mediated pro inflammatory cytokine secretion."

27264972

---

➶

reach

"Our results suggest that IKK2 inhibition by its specific inhibitor TPCA-1 is able to block laser induced CNV through the IKK-NF-kappaB signaling pathway, and in turn, the transcription of its downstream target genes that promote neovascularization."

24489934

---

➶

reach

"TPCA-1 is an inhibitor of IKK2 and, thus, inhibits NF-kappaB signaling by preventing IkappaB degradation."

22246000

---

➶

reach

"Our study demonstrated [XREF_BIBR] pleiotropy for TPCA-1, which inhibited not only IKK-beta [XREF_BIBR - XREF_BIBR], but also JAK1 kinase activity [XREF_BIBR]."

27533247

Serotonin affects ITCH

| 14

Serotonin inhibits ITCH. 14 / 14

| 14

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➶

reach

"Similar to dermatitis models, blocking serotonin signaling and PAR2 can also effectively reduce itch in dry skin models [XREF_BIBR, XREF_BIBR]."

26385480

---

➶

reach

"Increasing level of 5-HT in the central nervous system (CNS) inhibited itch and induced antinociception in sham and BDL rats."

27824106

---

➶

reach

"49 A reduction in scratch response in rats following serotonin induced itch was also shown following acupuncture treatment."

30886746

---

➶

reach

"Separately, it has been shown that administration of a nitric oxide (NO) donor to skin enhances substance P induced itch in mice, while serotonin induced itch was inhibited by systemic nitric oxide synthase (NOS) inhibitors."

28119997

---

➶

reach

"Attenuation of serotonin induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase."

24915981

---

➶

reach

"It has been suggested that serotonin may cause itch in humans via serotonin induced release of histamine from mast cells, although administration of antihistamines failed to result in a significant reduction of serotonin induced itch compared to placebo treatment."

24875173

---

➶

reach

"Attenuation of serotonin induced itch by sumatriptan : possible involvement of endogenous opioids."

29352328

---

➶

reach

"In addition, acute itch triggered by serotonin or a selective serotonin reuptake inhibitor required both HTR7 and TRPA1."

26074006

---

➶

reach

"Depletion of supraspinal serotonin reduced itch behavior, indicating that serotonergic pathways descending from the rostral ventromedial medulla may tonically facilitate itch [XREF_BIBR] (XREF_FIG)."

27578065

---

➶

reach

"Thus, the results suggested application 5-HT or 5-HT receptor agonists, including 5-HT 1A, 5-HT 2A, 5-HT 3 or 5-HT 7, inhibited itch sensation possible through over-activation of these 5-HT receptors subtypes in the spinal cord."

27824106

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➶

reach

"Anecdotal and limited data suggest that gabapentin, cutaneous field stimulation, serotonin antagonists, and ultraviolet B phototherapy may attenuate itch in some of these patients."

15811075

---

➶

reach

"5-HT 1A, 5-HT 2, 5-HT 3, and 5-HT 7 agonists or antagonists suppressed itch in BDL rats."

27824106

---

➶

reach

"Our results showed that antagonism of 5-HT 1A, 5-HT 2A, 5-HT 3 or 5-HT 7, inhibited itch sensation in BDL rats, suggested increased endogenous 5-HT in spinal cord of BDL rats might play an itch facilitating effect through 5-HT 1A, 5-HT 2A, 5-HT 3 or 5-HT 7."

27824106

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➶

reach

"Therefore, we investigated if sumatriptan has inhibitory effects on serotonin induced itch in mice."

29352328

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects NFKBIA

| 1 13

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits NFKBIA. 14 / 14

| 1 13

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➶

reach

"In order to check that the decreased band intensity in IKKbeta expressing cells was due to accelerated degradation of IkappaBalpha, one set of cells were also treated with the proteasome inhibitor MG-132 for 2hours, resulting in equal IkappaBalpha protein levels in both the samples."

22590978

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➶

reach

"Further experiments indicated that such degradation of IkappaBalpha accelerated by IFIT5 was inhibited by MG132, a proteasome inhibitor, whereas IKKbeta phosphorylation enhanced by IFIT5 remained unaffected, which suggested that IKK phosphorylation enhanced by IFIT5 was independent of IkappaBalpha degradation.Since degradation of IkappaBalpha could lead to the release of NF-kappaB to the nucleus and subsequently activates the transcription of NF-kappaB regulated genes, we further tested whether p65 nuclear localization was increased when IFIT5 was overexpressed."

26334375

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➶

reach

"In in vitro studies using protease inhibitors, IkappaBalpha proteolysis in ts1 infected astrocytes was significantly blocked by a specific calpain inhibitor calpeptin but not by MG-132, a specific proteasome inhibitor, whereas rapid IkappaBbeta proteolysis was blocked by MG-132."

11582519

---

➶

reach

"In a manner consistent with this observation, ZnO stimulation in the absence of MG132 caused IkappaBalpha degradation at 30 min exposure to ZnO (XREF_FIG)."

20194077

---

➶

reach

"In summary, we showed that the proteasome inhibitor MG132 is able to inhibit the activation the NFkappaB pathway by inhibiting the degradation of IkappaBalpha in vitro."

21843349

---

➶

reach

"To assess whether TSPAN15 promotes the BTRC mediated degradation of p-IkappaBalpha, TSPAN15 expressing cells and control cells were further treated with a proteasome inhibitor MG132 (Selleck Chemicals, Houston, TX)."

29650964

---

➶

reach

"In addition, inhibition of IkappaB-alpha degradation by MG-132 resulted in apoptosis."

15528993

---

➶

medscan

"The proteosome inhibitor MG-132 blocks the degradation of IκB-α [ ]."

16620395

---

➶

reach

"PD98059 as well as MG132, an NF-kappaB pathway inhibitor, blocked both IL-8 production and degradation of IkappaBalpha induced by H. pylori infection, whereas only PD98059 inhibited ERK activity in response to H. pylori."

12106602

---

➶

reach

"We used an NFkappaB dependent luciferase reporter assay to confirm that MG132 suppressed NFkappaB activity by inhibiting the proteasomal degradation of IkappaBalpha."

21843349

---

➶

reach

"Both MG115 and MG132 markedly inhibited the I of IKBa observed in response to TNFa."

7538441

---

➶

reach

"Three hours later, IkappaBalpha starts to degrade, and ERK returns to basal or non phosphorylation, and this lasts for the next 12 h. Finally, expression of CD3 and CD8 occurs in MOLT-4 along with reappearance of the IkappaBalpha.ERK.WWOX complex near 24 h. Inhibition of ERK phosphorylation by U0126 or IkappaBalpha degradation by MG132 prevents MOLT-4 maturation."

27339895

---

➶

reach

"IkappaBalpha proteolysis induced by TNF-alpha occurred through the 26S proteasome, as both 26S proteasome activity and IkappaBalpha proteolysis were blocked by specific inhibitors lactacystin, MG-132, and ZLLF-CHO."

9573251

---

➶

reach

"A proteasome inhibitor, MG132, was used to inhibit degradation of IkappaBalpha in cells cotransfected with CIS and V5-IkappaBalpha vectors as previously reported."

19592657

Sulindac affects IKBKB

1 | 1 5 6

Sulindac inhibits IKBKB. 13 / 13

1 | 1 5 6

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➶

reach

"Consistent with our results, XREF_BIBR have demonstrated that inhibition of IKK2 by sulindac, which is a selective inhibitor of NEMO, resulted in the decrease of IgE stimulated histamine release from mast cells."

18692471

---

➶

reach

"Concentrations of sulindac that inhibit IKKbeta activity also reduce the proliferation of colon cancer cells."

10480951

---

➶

reach

"Consistent with our results, Peng et al. (2005) have demonstrated that inhibition of IKK2 by sulindac, which is a selective inhibitor of NEMO, resulted in the decrease of IgE stimulated histamine release from mast cells."

18692471

---

➶

ctd

No evidence text available

19526344

---

➶

sparser

"Using a combination of chemical kinase inhibitors and siRNA-mediated knockdown of specific kinases, we found that sulindac inhibits IKKbeta, which, in turn, leads to the p38 MAPK-dependent activation of JNK1."

19526344

---

➶

reach

"Sulindac [75], aspirin and salicylate [76] specifically inhibit IkKB kinase activity, and sanguinarine has also been shown to inhibit NFkB activation at the level of IkB phosphorylation [77]."

12419552

---

➶

reach

"Using a combination of chemical kinase inhibitors and siRNA mediated knockdown of specific kinases, we found that sulindac inhibits IKKbeta, which, in turn, leads to the p38 MAPK dependent activation of JNK1."

19526344

---

➶

medscan

"Using a combination of chemical kinase inhibitors and siRNA-mediated knockdown of specific kinases, we found that sulindac inhibits IKKbeta, which, in turn, leads to the p38 MAPK-dependent activation of JNK1."

19526344

---

➶

sparser

"Consistent with our results, xref have demonstrated that inhibition of IKK2 by sulindac, which is a selective inhibitor of NEMO, resulted in the decrease of IgE-stimulated histamine release from mast cells."

18692471

---

➶

sparser

"Aspirin, salicylate, and sulindac can directly bind and inhibit recombinant IKKβ, the upstream positive regulator of NF-κB ( xref )."

23875171

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➶

sparser

"Lastly, direct inhibition of IKKβ by aspirin, salicylate, and sulindac may be another mechanism that could account for the antiproliferative effects of these NSAIDs via downregulation of NF-κB-mediated proliferative genes such as interleukin-2 (IL-2), granulocyte-macrophage colony-stimulating factor (GM-CSF), c-myc, cyclin D1, and COX-2, among others."

23875171

---

➶

reach

"Moreover, sulindac was reported to inhibit in vitro IKKbeta, but not IKKalpha, protein kinase activity, suggesting that it might be possible to find isoform specific inhibitors of IKK."

12110242

---

➶

sparser

"Consistent with our results, have demonstrated that inhibition of IKK2 by sulindac, which is a selective inhibitor of NEMO, resulted in the decrease of IgE-stimulated histamine release from mast cells."

18692471

Scutellarin(1-) affects NLRP3

| 13

Scutellarin(1-) inhibits NLRP3. 13 / 13

| 13

---

➶

reach

"These results indicated that scutellarin inhibited NLRP3 inflammasome activation in macrophages upon ATP treatment."

29375379

---

➶

reach

"The results showed that scutellarin dose-dependently reduced caspase-1 activation and decreased mature interleukin-1beta (IL-1beta) release in lipopolysaccharide (LPS)-primed macrophages upon ATP or nigericin stimulation, indicating that scutellarin inhibited NLRP3 inflammasome activation in macrophages."

29375379

---

➶

reach

"We demonstrated that scutellarin inhibited NLRP3 inflammasome activation and pyroptosis in macrophages through augmenting PKA signaling, unraveling a novel anti-inflammatory mechanism beyond previously identified inhibitory action on the NF-kappaB and Notch pathways."

29375379

---

➶

reach

"We found that scutellarin inhibited NLRP3 inflammasome activation by both ATP and nigericin, suggesting that its action may on the downstream components of P2X7 receptor."

29375379

---

➶

reach

"Altogether, these data indicated that scutellarin inhibited NLRP3 inflammasome activation and pyroptosis in macrophages by augmenting PKA signaling."

29375379

---

➶

reach

"Scutellarin Suppresses NLRP3 Inflammasome Activation in Macrophages and Protects Mice against Bacterial Sepsis."

29375379

---

➶

reach

"These data indicated that scutellarin suppressed NLRP3 inflammasome activation in macrophages by augmenting PKA signaling, highlighting its potential therapeutic application for treating NLRP3 related inflammatory diseases."

29375379

---

➶

reach

"Together these results showed that scutellarin treatment inhibited NLRP3 inflammasome activation and pyroptosis in LPS primed murine macrophages upon ATP or nigericin stimulation."

29375379

---

➶

reach

"We report that scutellarin partially inhibited the activation of NLRP3 inflammasomes under hypoxic conditions in vitro and in vivo, improved the survival rate of RGCs, and decreased the number of impaired retinal microglia."

| PMC

---

➶

reach

"Together, these results indicated that scutellarin inhibited NLRP3 inflammasome activation and pyroptosis by augmenting PKA signaling in murine macrophages."

29375379

---

➶

reach

"Our data reveals that scutellarin is able to suppress NLRP3 inflammasome activation thus exhibiting therapeutic effects against NLRP3 related inflammatory diseases."

29375379

---

➶

reach

"In light of the fact that scutellarin can increase cAMP levels (and therefore increases the PKA activity), we proposed that scutellarin might block NLRP3 activation by enhancing PKA signaling."

29375379

---

➶

reach

"In this study, we found that scutellarin inhibited NLRP3 inflammasome activation and pyroptosis in LPS primed macrophages upon ATP or nigericin stimulation."

29375379

Ruxolitinib affects TYK2

10 | 3

Ruxolitinib inhibits TYK2. 13 / 13

10 | 3

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23668484

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21106455

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"Ruxolitinib, which inhibits JAK2 but also TYK2, JAK1 and JAK3 XREF_BIBR at similar degrees demonstrated durable reduction in splenomegaly and constitutional symptoms with improved quality of life in comparison to placebo controlled XREF_BIBR or best available therapy XREF_BIBR in phase 3 trials and an impact on survival for patients originally randomized to ruxolitinib compared with those originally randomized to placebo in both COMFORT trials XREF_BIBR."

26176817

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26927423

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22698084

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"Tofacitinib and ruxolitinib also inhibited all of the JAK enzymes, but the JAK3 inhibition by tofacitinib and JAK2 and Tyk2 inhibition by ruxolitinib were significantly more potent than those of JTE-052."

25387665

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24461299

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22591402

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"Ruxolitinib is claimed to be a specific inhibitor of the Janus kinases JAK1 and JAK2, but does not block JAK3 or TYK2, and we next determined whether knock down of JAK1 and JAK2 could account for the effects of ruxolitinib."

27379204

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24417533

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23061660

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22037378

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29298069

Ruxolitinib phosphate affects JAK1

13 |

Ruxolitinib phosphate inhibits JAK1. 13 / 13

13 |

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25369270

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23540648

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24461299

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27137359

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21106455

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24417533

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29298069

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22037378

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22698084

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22591402

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26927423

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23061660

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| DOI

Parthenolide affects CASP1

| 4 9

Parthenolide inhibits CASP1. 13 / 13

| 4 9

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"Parthenolide has also been shown to directly inhibit caspase-1 by alkylation of the enzyme 's p20 subunit [XREF_BIBR]."

27191349

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"Our results disagree with this assertion as we did not find that parthenolide inhibited caspase-1 in response to AIM2 stimulation."

22216309

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"Parthenolide has previously been shown to inhibit NLRC4 dependent caspase-1 activation 15, although it did not do so in these experiments (XREF_FIG)."

25686105

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"To test the hypothesis that activation of NF-kB is necessary for the inhibition of cell proliferation by chloroquine and 6-AN, we treated the cells with parthenolide, which inhibits both p65 and RelA and caspase-1 via alkylation 16."

24296756

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"The effect of parthenolide on the spectrum of inflammasomes implies that it acts on a common component and, accordingly, it has been shown that parthenolide is a direct inhibitor of caspase-1, causing alkylation of caspase-1 on a number of cysteine residues."

25653548

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"However, the previous study xref did not test AIM2 activation so perhaps parthenolide only inhibits caspase-1 in response to NLRP3 or NLRC4 activation."

22216309

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"XREF_BIBR have shown that parthenolide directly inhibits caspase-1 by alkylation of certain cysteine residues."

22216309

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"Notably, the combination of chloroquine and 6-AN triggered activation of the NF-kB and inflammasome pathways in a TSC2 dependent manner, and parthenolide 16, which inhibits both NF-kB and caspase-1, rescued proliferation under these conditions."

24296756

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"To test the hypothesis that activation of NF-kB is necessary for the inhibition of cell proliferation by chloroquine and 6-AN, we treated the cells with parthenolide, which inhibits both p65/RelA and caspase-1 via alkylation xref ."

24296756

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"XREF_BIBR It was thought to be an NFkappaB inhibitor through selective inhibition of kappaB kinase beta (IKKbeta) kinase activity; however, in addition to its effects on NFkappaB activation, parthenolide has now been shown to inhibit activation of caspase-1 in response to NLRP3, NLRP1, and NLRC4 stimulation."

25653548

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"Since parthenolide inhibits both NF-kappaB and caspase-1 activation, we determined whether this result is due predominantly to inflammasome inhibition by treating THP-1 cells with Bay 11-7082, which selectively inhibits the NLRP3 inflammasome independently of its effect on NF-kappaB activity."

20434582

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"Juliana et al. xref have shown that parthenolide directly inhibits caspase-1 by alkylation of certain cysteine residues."

22216309

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"Our results disagree with this assertion as we did not find that parthenolide inhibited caspase-1 in response to AIM2 stimulation."

22216309

Curcumin affects NFKBIA

| 1 12

Curcumin inhibits NFKBIA. 13 / 13

| 1 12

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"To test the effect of curcumin and HCWE on TNFalpha induced IkappaBalpha degradation, HeLa 229 cells were treated with curcumin (10muM) or HCWE (450mug/ml) for 2h, then stimulated with 1ng/ml TNFalpha for 20min."

21951655

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"Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis."

12393461

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"Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis."

12393461

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"Since the first report from our laboratory in 1995 that curcumin can inhibit activation of the proinflammatory transcription factor NF-kappaB by inhibiting the 26S proteasomal degradation of IkappaBalpha, an inhibitor of NF-kappaB, this yellow pigment has been shown to inhibit the protease activities of the proteasome."

23834173

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"Western blotting of total cell lysates to measure protein expression of phosphorylated p65 (p-p65) and IkappaBalpha (p- IkappaBalpha) revealed that curcumin treatment rapidly suppressed p-p65 and p-IkappaBalpha, but this effect was negligible after 30 and 60 min (XREF_FIG)."

25369140

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"Moreover, curcumin significantly inhibited PMA induced p-ERK, p-p38, p-JNK, p-Ikappa-Balpha and NF-kappaB."

26507910

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eidos

"Curcumin inhibits the IkappaBalpha degradation , phosphorylation of IkappaB serine 32 to block the cytokine-mediated NF-kappaB activation and thus pro-inflammatory gene expression ( Jobin et al ., 1999 ) ."

32596244

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"Next, we examined whether inhibition of IL-1beta-induced IkappaBalpha degradation was through inhibition of IkappaBalpha phosphorylation, the tenocytes were treated with curcumin and then with IL-1beta and examined for IkappaBalpha phosphorylation in the cytoplasm by Western blot analysis."

21669872

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"A recent study suggests that the curcumin derivative EF24 suppresses NF-kappaB activation by directly inhibiting the degradation of I-kappa-B-alpha [XREF_BIBR], the inhibitory cytosolic subunit of NF-kappaB, whose phosphorylation and subsequent degradation is a prerequisite for activation of the NF-kappaB pathway."

27401816

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"The molecular analysis of curcumin induced macrophage polarization demonstrated that curcumin inhibits the M1 macrophage phenotype by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and by activating IkappaBalpha, and by promoting the M2 phenotype through the activation of proliferator activated receptor gamma (PPAR-gamma)."

28197150

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"Curcumin but not resveratrol inhibits IL-1beta-induced IkappaBalpha kinase activation."

19889203

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reach

"As demonstrated in Figure XREF_FIG, curcumin suppressed IL-1beta-induced activation of Ikappa-Balpha in MSCs."

20594343

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reach

"Consistent with our data, curcumin was shown to inhibit the activation of NF-kappaB, Bharat et al. has reported curcumin down-regulates the constitutive activation of NF-kappaB and IkappaBalpha kinase in human multiple myeloma cells."

28261097

S-Ruxolitinib affects JAK1

13 |

S-Ruxolitinib inhibits JAK1. 13 / 13

13 |

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26927423

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23061660

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| DOI

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29298069

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24461299

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27137359

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22591402

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22698084

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23540648

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21106455

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22037378

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25369270

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24417533

3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]propanenitrile affects JAK1

13 |

3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]propanenitrile inhibits JAK1. 13 / 13

13 |

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22591402

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21106455

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23061660

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27137359

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23540648

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22698084

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22037378

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24417533

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29298069

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26927423

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24461299

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25369270

3',5'-cyclic AMP affects JUN

| 13

3',5'-cyclic AMP inhibits JUN. 13 / 13

| 13

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"HDAC4 mediates cAMP dependent repression of c-Jun in cultured Schwann cells."

29472387

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"During B cell activation, cAMP negatively regulates raf-1 and erk-2, but not Jun kinase activation in response to BCR ligation, while activation of both erk-2 and Jun kinase through the PKA-insensitive CD40 signaling pathway is not affected (Kawauchi et al., 1996)."

9881695

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"Finally, c-Jun down-regulation by cAMP was reversed by incubation with 2 microM TSA, a deacetylase inhibitor that efficiently inhibits class I HDACs (including HDAC3) and class IIb HDACs but not class IIa HDACs."

29472387

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reach

"Moreover, other studies suggest that cAMP mediated signals can repress induction of c-jun through this element (de Groot et al. 1991; Mechta et al. 1989)."

8341367

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"Finally, these authors demonstrate that the capacity of cAMP to downregulate c-Jun in Schwann cells disappears when the deacetylase activity is inhibited with triscostatin A."

29729650

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reach

"Intriguingly, cAMP down-regulates c-Jun, a basic leucine zipper domain transcription factor expressed by immature Schwann cells that negatively regulates the expression of the myelin master gene Krox20."

29472387

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reach

"Loss of HDAC4 function prevented not only cAMP induced c-Jun down-regulation but also induction of Krox20 (immunofluorescence intensity = 74.89 +/- 1.89 a.u. for Lv control infected cells and 30.36 +/- 0.78 a.u. for Lv shHDAc4 infected Schwann cells; XREF_FIG) and Periaxin (81.29 +/- 2.28 in control vs. 42.63 +/- 1.52 in Lv shHDAC4 infected cells; XREF_FIG)."

29472387

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"In summary, we propose a model in which class IIa HDACs are pivotal components of an intracellular cAMP sensor mechanism that blocks c-Jun, allowing the activation of the myelin gene expression program and differentiation of Schwann cells."

29472387

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reach

"In primary hepatocyte cultures, supplemental cAMP inhibited JNK and ERK activity, total AP-1 and c-Jun transcriptional activities, and DNA synthesis."

8944691

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➶

reach

"Neither cyclic AMP response element binding protein nor c-fos antisense oligonucleotide injection reduced c-Jun immunostaining in the striatum."

7617161

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reach

"Interestingly, c-Jun up-regulation and the transition to the activated phenotype can be blocked by cAMP."

29472387

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reach

"In T cells, however, cAMP accumulation inhibits the activity of Jun kinase but not MAPK (Hsueh and Lai, 1995), suggesting that differential targets of PKA exist in distinct cell types."

9881695

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reach

"Transcription of c-Jun is induced by ERK5, and like ERK5, c-Jun induction is also blocked by cAMP."

16581779

Nitric oxide affects RELA

| 12

Nitric oxide inhibits RELA. 12 / 12

| 12

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"We experimentally validated this bioinformatic prediction, and found that the p65 and RelA subunit of NF-kB is inhibited by NO production during IFN-gamma activation of M. tuberculosis infected macrophages."

28754681

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➶

reach

"We experimentally validated this bioinformatic prediction, and found that the p65 and RelA subunit of NF-kB is inhibited by NO production during IFN-gamma activation of M. tuberculosis infected macrophages."

28754681

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➶

reach

"Second, we find that NO represses NF-kB signaling, and prevents prolonged nuclear RelA localization."

28754681

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➶

reach

"Serum starvation also induces NOS2 derived NO; modulation of RelA by NO was verified in serum starved MB-468 cells in the presence and absence of both the NOS inhibitor l-NAME (N G -nitro-l-arginine methyl ester) and DETA/NO (XREF_SUPPLEMENTARY)."

29087320

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reach

"Electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP) assays further demonstrate that the p65 subunit of NF-kappaB and not p50 binding is specifically decreased by NO treatment."

16539692

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reach

"In addition, MS-275 and SAHA suppressed lipopolysaccharide (LPS)-induced NF-kappaB p65 nuclear accumulation, IL-6, IL-18 and nitric oxide (NO) secretion as well as down-regulated pro angiogenic VEGF and MMP-2 and MMP-9 production in E11 cells at sub-micromolar levels."

20421217

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reach

"NO promoted p65 S nitrosylation reduces p65 mediated transactivation of the NIS promoter in response to TSH stimulation."

26587909

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reach

"Our experiments indicate that NO mediates S nitrosylation and inhibits NF-kappaB p65 activation in the brain of infected mice."

26915097

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➶

reach

"For example, NO 2 -FAs inhibit NFkB activity by nitroalkylating the p65 subunit, thereby suppressing NFkB mediated pro inflammatory cytokine and adhesion protein expression [XREF_BIBR]."

19857569

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➶

reach

"In addition, MS-275 and SAHA suppressed lipopolysaccharide (LPS)-induced NF-kappaB p65 nuclear accumulation, IL-6, IL-18 and nitric oxide (NO) secretion as well as down-regulated pro angiogenic VEGF and MMP-2 and MMP-9 production in E11 cells at sub-micromolar levels."

20421217

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reach

"NO exposure also caused significant reductions of cytosol fraction p65 and p52 content in PAEC."

10516220

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reach

"Taken together, our results suggested that sauchinone could inhibit production of NO in LPS stimulated RAW264.7 cells through the suppression of NF-kappaB by inhibiting transactivation activity of RelA subunit."

14750024

Melatonin affects CASP1

| 3 9

Melatonin inhibits CASP1. 12 / 12

| 3 9

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➶

medscan

"Consistent with our observations in cellular models for Huntington's disease ( ), we found that melatonin inhibits Rip2 upregulation and caspase-1 activation in R6/2 mice ( )."

21994366

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reach

"Likewise, as shown in Figures XREF_FIG and XREF_FIG, the proportion of double positive cells (activated caspase-1 and PI) analyzed with flow cytometry was obviously increased after radiation (7.39 +/-2.27%), while the caspase-1 + PI + cells were significantly attenuated by melatonin (4.65 +/-1.54%, p < 0.05)."

30755784

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reach

"Consistent with our observations in cellular models for HD (XREF_FIG), we found that melatonin inhibits Rip2 upregulation and caspase-1 activation in R6/2 mice (XREF_FIG)."

21994366

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➶

reach

"Given that melatonin inhibits caspase-1 activation, we determined if this effect involves blocking Rip2 upregulation."

21994366

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➶

medscan

"Given that melatonin inhibits caspase-1 activation, we determined if this effect involves blocking Rip2 upregulation."

21994366

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➶

reach

"Melatonin inhibits the caspase-1 and cytochrome c/caspase -3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis."

23537713

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➶

reach

"As demonstrated by immunoblotting and complementary fluorogenic assay, melatonin inhibits mutant htt induced caspase-1 activation (XREF_FIG)."

21994366

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➶

reach

"Methazolamide and melatonin inhibit oxygen and glucose deprivation -- induced cell death, loss of mitochondrial membrane potential, release of mitochondrial factors, pro--IL-1beta processing, and activation of caspase-1 and -3 in primary cerebrocortical neurons."

19299628

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➶

reach

"We recently reported that melatonin inhibits caspase-1 activation in an experimental model of cerebral ischemia."

21994366

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➶

medscan

"We recently reported that melatonin inhibits caspase-1 activation in an experimental model of cerebral ischemia ( )."

21994366

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➶

reach

"An additional new finding is the demonstration that melatonin inhibits hypoxia induced caspase-1 activation."

19299628

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➶

reach

"We determined whether melatonin inhibits Rip2 accumulation and counters caspase-1 activation."

21994366

Lipopolysaccharide affects TRAF6

| 12

Lipopolysaccharide inhibits TRAF6. 12 / 12

| 12

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"We found that while treatment of 2muM caerulein alone increased the levels of Traf6 expression significantly, the combination of 2muM caerulein and 1muM LPS suppressed the activation of Traf6 by caerulein (XREF_FIG)."

26633718

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➶

reach

"In addition, miR-146a-5p mimic blocked LPS induced TRAF6 upregulation, as well as LPS induced c-Jun N-terminal kinase (JNK) activation and chemokine CCL2 expression in astrocytes."

25957028

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➶

reach

"Therefore, we drew the conclusion that LPS down-regulated miR-132 and miR-132 attenuated LPS induced inflammatory cell injury by targeting TRAF6, along with the inhibition of the NF-kappaB and MEK and ERK pathways."

29377244

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➶

reach

"XREF_BIBR Notably, TRAF6 is not degraded by LPS stimulation suggesting that the ubiquitin editing function of A20 may be specific for RIP1."

20543575

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➶

reach

"miR-140 regulates inflammatory cytokine secretion of LPS induced colorectal cancer cells by targeting TRAF6."

31882548

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➶

reach

"In addition, miR-146a-5p mimic blocked LPS induced TRAF6 dependent c-Jun N-terminal kinase (JNK) and Smad2 activation as well as alpha-SMA production."

27399683

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➶

reach

"To examine whether LPS played a direct role in the inhibition of Traf6 expression, cells were treated with caerulein or LPS alone, or both in different combinations for 48h, and collected for western blotting analysis."

26633718

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➶

reach

"Interestingly, LPS stimulated splenic B cell proliferation was inhibited in TRAF6 deficient mice."

10817965

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reach

"17 For instance, LPS inducible miR-146a downregulates TNF receptor associated factor 6 (TRAF6), interleukin-1 receptor associated kinase 1 (IRAK1) and tumor necrosis factor alpha (TNF-alpha) that renders cells refractive to further stimuli, while miR-21 regulates expression of programmed cell death 4 (PDCD4), a proinflammatory protein which induces NF-kappaB and IL-6 production."

24062196

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➶

reach

"Our recent reports have shown that miR-146a is critical for LPS induced tolerance [XREF_BIBR] and cross-tolerance [XREF_BIBR] in monocytic cells by repressing IRAK1 and TRAF6 adaptor molecules."

25896300

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➶

reach

"MiR-643 inhibits lipopolysaccharide induced endometritis progression by targeting TRAF6."

31930635

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➶

reach

"MicroRNA-132 attenuates LPS induced inflammatory injury by targeting TRAF6 in neuronal cell line HT-22."

29377244

Calcium(2+) affects NLRP3

| 12

Calcium(2+) inhibits NLRP3. 12 / 12

| 12

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➶

reach

"Interestingly, Ca 2+ signaling contributes to dysregulated NLRP3 inflammasome activation in CAPS, a spectrum of autoinflammatory diseases caused by mutations in NLRP3 [XREF_BIBR]."

24646829

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➶

reach

"BAPTA, a strong Ca 2+ chelator and buffer of cytosolic Ca 2+, can inhibit NLRP3 inflammasome activation and IL-1beta processing independently of its function as a Ca 2+ chelator 28."

30755589

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➶

reach

"The absence of extracellular Ca 2+ effectively eliminated the increases in cytosolic [Ca 2+] in response to nigericin or ATP but did not attenuate NLRP3 inflammasome activation in BMDC."

25762778

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➶

reach

"The intracellular decrease of K + and increase of Ca 2+ levels trigger NLRP3 activation [XREF_BIBR]."

29137224

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➶

reach

"Lee et al. proposed a critical role for calcium sensing receptor (CASR) in activating the NLRP3 inflammasome that is mediated by increased intracellular Ca 2+ and decreased cellular cyclic AMP (cAMP) 21."

29491386

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➶

reach

"Activation of the NLRP3 inflammasome by ATP and other stimuli was reported to require Ca 2+ signaling as inhibition of Ca 2+ release from the ER and blocking extracellular Ca 2+ influx inhibited NLRP3 inflammasome function, presumably by preventing Ca 2+ induced mitochondrial damage."

26109647

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➶

reach

"Methods : Vascular reactivity, reactive oxygen species (ROS) generation, calcium (Ca 2+) influx and caspase-1 and IL-1beta activation were determined in mesenteric resistance arteries from normoglicemic and streptozotocin induced diabetic C57BL/6 and NLRP3 knockout (Nlrp3 -/-) mice."

32009974

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➶

reach

"Because blocking TRPM2 mediated calcium mobilization drastically impaired caspase-1 activation and did not affect mitochondrial ROS production, it is possible that, unlike ER derived calcium, TRPM2 mediated calcium influx may directly signal activation of the NLRP3 inflammasome."

23511475

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➶

reach

"Recent studies suggest that nitric oxide (NO), Ca 2+ and cyclic AMP negatively regulate the NLRP3 inflammasome but the detailed mechanisms are unclear XREF_BIBR, XREF_BIBR."

27439607

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➶

reach

"Katsnelson et al. provided new insights that increasing LMP resulted in NLRP3 ubiquitination, and LMP induced Ca 2+ influx attenuated the association of NLRP3 with ASC [XREF_BIBR]."

27941683

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➶

reach

"The combination of increased cytosolic Ca 2+ and decreased cAMP was suggested to activate NLRP3."

23666718

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➶

reach

"Nevertheless, there is currently no convincing explanation as to why in certain experimental systems the removal of extracellular Ca 2+ seems to inhibit NLRP3, while in other setups such treatment does not interfere with NLRP3 activation."

27508077

3-hydroxybutyric acid affects NLRP3

| 3 9

3-hydroxybutyric acid inhibits NLRP3. 12 / 12

| 3 9

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➶

reach

"Beta-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares."

28249154

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➶

reach

"However, beta-hydroxybutyrate inhibited NLRP3 inflammasome in macrophages such as immune response [XREF_BIBR]."

27661104

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sparser

"As described above, BHB inhibits NLRP3 in peripheral macrophages to affect inflammation-mediated disease38 , 40 and inhibits NF-κB-mediated inflammation by binding to HCAR2 on central-nervous-system-resident macrophages."

32838361

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➶

reach

"Recently, one of the ketone bodies, beta-hydroxybutyrate, was shown to specifically inhibit NLRP3 inflammasome [XREF_BIBR] and synthetic compound MCC950 demonstrated effective and specific NLRP3 inflammasome inhibition with promising results in the mouse model of CAPS [XREF_BIBR]."

27467658

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➶

reach

"Sodium Butyrate and beta-Hydroxybutyric Acid Topical Treatment Inhibits Activation of NLRP3 Inflammasome in Alkali Injured Corneas."

28273882

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➶

reach

"For example, the ketone metabolite beta-hydroxybutyrate mediates NLRP3 inflammasome inhibition in an ROS independent manner XREF_BIBR."

26659006

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➶

sparser

"As described above, BHB inhibits NLRP3 in peripheral macrophages to affect inflammation-mediated disease xref , xref and inhibits NF-κB-mediated inflammation by binding to HCAR2 on central-nervous-system-resident macrophages. xref , xref Oxidation of the ketone body acetoacetate by liver-resident macrophage-like Kupffer cells reduces fibrosis in mouse models of high-fat liver injury. xref Whether this modulation of innate immune responses extends to alveolar macrophages and the lung, and whether ketone bodies would thereby slow the inflammation and fibrosis of ARDS, is an area for investigation."

32838361

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➶

reach

"Beta-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares."

28249154

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➶

reach

"Ketone body beta-hydroxybutyric acid (HBA) has a similar chemical structure as NaB and was also reported to inhibit NLRP3 activation [XREF_BIBR], and has been shown to decrease apoptosis of rat corneal epithelia in dry eye conditions [XREF_BIBR]."

28273882

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➶

reach

"For example, the ketone body, b-hydroxybutyrate, which specifically inhibits NLRP3 inflammasome activation via potassium efflux blockade, and the naturally derived antioxidant, sulforaphane, have been shown to attenuate MSU induced responses in murine models of gout."

29892292

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➶

reach

"In human monocytes beta-hydroxybutyrate was recently shown to inhibit NLRP3 inflammasome, responsible for activation of caspase-1 and the release of the pro inflammatory cytokines IL-1beta and IL-18."

32411143

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"As described above, BHB inhibits NLRP3 in peripheral macrophages to affect inflammation-mediated disease 38,40 and inhibits NF-kB-mediated inflammation by binding to HCAR2 on central-nervous-system-resident macrophages."

32838361

(-)-epigallocatechin 3-gallate affects ITCH

| 12

(-)-epigallocatechin 3-gallate inhibits ITCH. 12 / 12

| 12

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"(D-E) Systemic administration of PBN (10-300 mg/kg; i.p.) and EGCG (50-200 mg/kg; i.p.) dose-dependently attenuated CQ induced itch in mice (C, F) Local administration of EGCG (50-200 mug; i.p.) dose-dependently attenuated 48/80 and CQ induced itch in mice."

29402411

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"Thus, the results showed that green tea polyphenon 60 or EGCG also inhibited acute histamine independent itch in mice.Our previous study found that oxidative stress contributed to compound 48/80 and CQ induced acute itch."

29402411

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reach

"In the present study, we demonstrated that systemic administration of polyphenon 60 or EGCG, dose-dependently attenuated compound 48/80- and CQ induced acute itch in mice."

29402411

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➶

reach

"Finally, EGCG treatment remarkably inhibited p-ERK and p-AKT in the spinal cord of mice in compound 48/80 induced acute itch and PSO induced chronic itch, respectively."

29402411

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reach

"Instead, EGCG inhibited p-AKT activation in the spinal cord dorsal horn by imiquimod induced psoriatic itch in mice."

29402411

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reach

"In the present study, we found EGCG reduced both histamine dependent and -independent itch, possible through multiple mechanisms in the periphery and central nervous system.Oxidative stress has long been considered to be responsible for pathogenesis of skin, systemic, and metabolic diseases [29]."

29402411

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reach

"EGCG also attenuated imiquimod induced chronic psoriatic itch behaviors and skin epidermal hyperplasia in mice."

29402411

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reach

"Thus, these results indicated that green tea polyphenon 60 or EGCG inhibited acute histamine dependent itch in mice.EGCG attenuated chloroquine (CQ)-induced histamine independent acute itch in mice.We next used mouse model of acute histamine independent itch induced by CQ to explore the potential effects of EGCG on acute itch."

29402411

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reach

"Application of EGCG also attenuated imiquimod induced chronic psoriatic itch."

29402411

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reach

"Taken together, these results indicated EGCG inhibited acute and chronic itch through distinct pathways in the spinal cord.In summary, we have demonstrated that green tea polyphenon 60 or EGCG treatment inhibited histamine dependent and -independent acute itch and imiquimod induced chronic psoriatic itch in mice."

29402411

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➶

reach

"In the present study, we asked whether EGCG reduced itch by suppression of oxidative stress."

29402411

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reach

"Thus, EGCG attenuated both histamine dependent and -independent acute itch, possible through decreasing the accumulation of ROS in primary sensory neurons."

29402411

Sorafenib affects MAPK14

10 | 1 1

Sorafenib inhibits MAPK14. 11 / 11

10 | 1

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No evidence text available

18183025

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No evidence text available

20621496

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No evidence text available

25778995

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No evidence text available

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No evidence text available

19654408

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No evidence text available

19962319

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➶

medscan

"Various liver cancer cell lines were treated with either sorafenib only or with sorafenib after infection of adenovirus expressing short hairpin RNA against transforming growth factor-β (TGF-β) and p38 activity was examined using western blotting. p38 MAP kinase activity was inhibited by low concentrations of sorafenib, which could potentially lead to sorafenib resistance in hepatocellular carcinoma cell lines."

28792132

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No evidence text available

15711537

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No evidence text available

18077425

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No evidence text available

17850214

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No evidence text available

22037378

Sorafenib inhibits mutated MAPK14. 1 / 1

| 1

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"Sorafenib uniquely inhibited SAPK2a mutant and Mnk2 kinases with submicromolar potency."

19844230

Parthenolide affects RELA

3 | 9

Parthenolide inhibits RELA. 9 / 9

| 9

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"However, parthenolide, a sesquiterpeno lactone that inhibits RelA activation by preventing the degradation of IkappaB-alpha XREF_BIBR, XREF_BIBR did not prevent p100 processing (XREF_FIG)."

20126461

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"To test the hypothesis that activation of NF-kB is necessary for the inhibition of cell proliferation by chloroquine and 6-AN, we treated the cells with parthenolide, which inhibits both p65 and RelA and caspase-1 via alkylation 16."

24296756

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"We demonstrated that parthenolide inhibited constitutive and paclitaxel induced RelA and NF-kappaB activity by interfering with the effect of paclitaxel on IKK-beta, thereby functionally inhibiting phosphorylation of I-kappaBalpha and subsequently leading to inhibition of NF-kappaB activity."

19067767

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"Parthenolide, a major sesquiterpene lactone from the plant Tanacetum parthenium, inhibits NF-kappaB both indirectly, by inhibiting the IkappaB kinase (IkappaK), and directly, by modifying p65 at a key cysteine residue in its activation loop [XREF_BIBR, XREF_BIBR]."

23039130

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"To test the hypothesis that activation of NF-kB is necessary for the inhibition of cell proliferation by chloroquine and 6-AN, we treated the cells with parthenolide, which inhibits both p65 and RelA and caspase-1 via alkylation 16."

24296756

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reach

"The sesquiterpene lactone parthenolide inhibits NF-kappaB by alkylating p65 at Cys."

26239915

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reach

"Both LY294002 and parthenolide inhibited EGF induced nuclear accumulation of NF-kappaB p65."

23383347

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reach

"Contrary to previous reports, we show that parthenolide, like other SLs, inhibits NF-kappaB most probably by alkylating p65 at Cys (38)."

11500489

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reach

"Tissue microarray of mouse tumors showed that parthenolide decreased scores of the cell proliferation marker Ki67 and p65 and NF-kB, whereas it increased p21 expression."

23037503

Parthenolide inhibits RELA. 3 / 3

3 |

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No evidence text available

16921510

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No evidence text available

20154269

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No evidence text available

19284563

U0126 affects JUN

| 3 9

U0126 inhibits JUN. 10 / 10

| 1 9

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"The persistent stretch highly activated c-Jun and elevated miR-34c expression; however, only U0126 significantly abolished the stretch induced activation of c-Jun and increase of miR-34c."

28580775

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reach

"EGF increased p-ERK1/2, c-Fos, c-Jun, and p-c-Jun levels, which were inhibited by U0126."

19937979

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reach

"S1P stimulated AP-1 subunits (c-Jun and c-Fos mRNA) expression was attenuated by U0126 and wortmannin, suggesting that MEK and PI3K and ERK cascade linking to AP-1 was involved in EGFR expression."

17902169

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"As shown in Figure XREF_FIG, both DPI and U0126 reduced the nuclear accumulation of JunB, c-Jun, and HIF-1alpha, but not Stat1 (which is DUOX2 independent) or Sp1 (which is constitutively expressed)."

27637085

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"MEK inhibitor U0126 inhibits viral gene expression [XREF_BIBR] as well as the activation of host c-Fos, c-Jun, c-Myc, and STAT1 molecules."

27854239

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➶

reach

"Both U0126 pretreatment and c-Jun knockdown resulted, as expected, in reduced c-Jun activation and binding."

27708396

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➶

reach

"Immunoprecipitation assay showed that hyperosmolarity increased the association of nuclear Sp1 with c-Jun, which was inhibited by U0126 and SP600125."

23816505

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➶

medscan

"GDF-15 or U0126 prevented c-Jun activation."

12514175

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➶

reach

"The MAPK inhibitor U0126 blocked ERK1/2 activation and reduced SC proliferation and also the upregulation of c-Jun."

24877090

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➶

reach

"GDF-15 or U0126 prevented c-Jun activation."

12514175

U0126 inhibits JUN. 2 / 2

| 2

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medscan

"We found that induction of both c-fos and c-jun by arsenite can be substantially inhibited by the MEK- selective inhibitor U0126, suggesting that the ERK pathway is critically involved in their up-regulation."

12547826

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➶

medscan

"In addition, we further demonstrated that the c-Jun N-terminal kinase inhibitor SP600125 and extracellular signal-regulated protein kinase inhibitor U0126 blocked the c-Jun activity and abolished hypoxia-induced 37-kDa laminin receptor precursor expression and promoter activity in a concentration-dependent manner."

28618937

Staurosporine affects IKBKB

8 | 3

Staurosporine inhibits IKBKB. 11 / 11

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"IKK-1 +2 and IKK-2 had similar K (m) values for ATP and GST-biotin-IkappaB (1-54) and were similarly inhibited by staurosporine and two of its analogues K252a and K252b, suggesting that most of the IkappaBalpha kinase activity in the IKK-1 +2 complex may be attributed to IKK-2."

10527519

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No evidence text available

25662701

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No evidence text available

23994329

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reach

"The strong inhibition of IKKbeta by staurosporine (K (i) = 172 nM) and ADP (K (i) = 136 nM) provides a rationale and structural framework for designing potent ATP-site inhibitors of IKKbeta, which is an attractive drug target for inflammatory diseases."

10551820

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No evidence text available

24389511

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No evidence text available

19481464

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No evidence text available

15225717

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No evidence text available

22037378

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No evidence text available

19338355

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reach

"Staurosporine can inhibit IKK2 by these regions through the binding of targets and as a reference to other compounds."

24987428

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No evidence text available

Sodium(1+) affects NFKB1

| 11

Sodium(1+) inhibits NFKB1. 11 / 11

| 11

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"Aspirin and sodium salicylate inhibit activation of NF-KB by blocking IkappaB kinase, a key enzyme in NF-kappaB activation."

10402163

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➶

reach

"It has been demonstrated, in human and mouse cell lines, that aspirin and sodium salicylate inhibit the activation of NFKB without af- fecting other transcription factors (Kopp and Ghosh, 1994)."

11545005

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➶

reach

"Sodium salicylate and prostaglandin A1 that inhibit NFk-B activity and restore growth control are experimental therapies for cylindromas."

27559531

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➶

reach

"Kopp E and Ghosh S, Inhibition of NF-KB by sodium salicylate and aspirin."

7786295

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➶

reach

"Kopp E, Ghosh S. Inhibition of NF-KB by sodium sal- L, Hwang D, Goldberg AL.."

8899295

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➶

reach

"ASA and sodium salicylate have been reported to inhibit activation of the transcription factors NFKB XREF_BIBR."

21829647

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➶

reach

"Kopp E and Ghosh S, Inhibition of NF-KB by sodium salicylate and aspirin."

9515564

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➶

reach

"Inhibition of NF-KB by sodium salicy d aspirin."

9383446

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➶

reach

"Inhibition of NFKB by sodium salicylate and aspirin."

8707445

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➶

reach

"Kopp E, Ghosh S : Inhibition of NF-KB by sodium salicylate and 84."

8939643

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➶

reach

"The amount of IKB-a in activated cells was reduced relative to untreated controls suggestingthat sodium salicylate may inhibit the activation of NFKB by interfering with the pathway resulting in the phos- phorylation or degradation of IKB."

11545005

Salicylic acid affects NFKB1

| 11

Salicylic acid inhibits NFKB1. 11 / 11

| 11

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"Salicylate probably inhibits NF-KB activation through an antioxidant mechanism : nonsalicylate cyclooxygenase inhibitors do not block NF-KB activation."

9265727

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reach

"The recent report demonstrated that salicylate like drugs, but not indomethacin, inhibit the activation of NF-KB by Lipopolysaccharides (LPS) (24)."

9718067

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➶

reach

"Aspirin and sodium salicylate inhibit activation of NF-KB by blocking IkappaB kinase, a key enzyme in NF-kappaB activation."

10402163

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➶

reach

"Sodium salicylate and prostaglandin A1 that inhibit NFk-B activity and restore growth control are experimental therapies for cylindromas."

27559531

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reach

"Recent experiments from our group [25] demonstrated that salicylic acid treatment (an inhibitor of some prostaglandin and cyclooxygenase pathways and NFKB) can inhibit UV- and cisplatin mediated HIV induction when salicylic acid is administered within the first 3 h following cisplatin exposure."

8642842

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reach

"It is pertinent that the NSAIDs aspirin and salicylate have long been known to also inhibit NFkB signaling by blocking IKKbeta activity [XREF_BIBR], most probably via the same thiol-reactive quinone type of irreversible binding interaction."

25688484

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reach

"The treatmentwith a non-steroidanti-inflammatory drug, such as a fluorated salicylate, which blocks con- stitutive NF-KB activation in the postnatal brain in vivo (Acarin et al., 2OOOc), has shown that block- ing glial NF-KB following a postnatal excitotoxic lesion causes an important downregulation of the glial responsewhich is accompaniedby a significant reduction of lesion volume (Acarin et al., 1999b; Gonzalez et al., 2000), therefore providing neuro- protection."

11545004

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reach

"Recent X-ray crystal analysis of DNA complex of p50 homodimer showed that the Rel homology region of p50 consists of two domains with immunoglobulin like structure and loops between anti- parallel 13-sheets recognize the major groove of ~ B DNA.27,28 Chemical inhibitors of NF-~ B reported so far include o-phenanthroline which inhibits the DNA binding of NF- B,29 antioxidants and anti- inflammatory drugs such as N-acetyl-L-cysteine,3 degrees pyrrolidine derivative of dithiocarbamate,31 vitamin E derivatives,32 cupric ion,33 sodium salicylate,34 and aspirin34which block the activa- tion of NF-KB."

9043672

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reach

"The amount of IKB-a in activated cells was reduced relative to untreated controls suggestingthat sodium salicylate may inhibit the activation of NFKB by interfering with the pathway resulting in the phos- phorylation or degradation of IKB."

11545005

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➶

reach

"It has been demonstrated, in human and mouse cell lines, that aspirin and sodium salicylate inhibit the activation of NFKB without af- fecting other transcription factors (Kopp and Ghosh, 1994)."

11545005

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➶

reach

"ASA and sodium salicylate have been reported to inhibit activation of the transcription factors NFKB XREF_BIBR."

21829647

Salicylate affects IKBKB

| 11

Salicylate inhibits IKBKB. 11 / 11

| 11

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"Salicylate inhibits IKKβ, to prevent the deleterious effects of excess FFA on insulin signaling and action [ xref , xref ]."

27128935

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➶

sparser

"IKKB is inhibited by salicylates, such as aspirin and sodium salicylate (SS; xref )."

23328071

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➶

sparser

"Accordingly, abrogation of inflammatory signaling with salicylates, which inhibit IKKβ, prevents inhibitory IRS-1 phosphorylation, restoring insulin sensitivity ()."

25035952

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➶

sparser

"To support this finding, inhibition of IKKβ by salicylate was effective in ameliorating inflammation-mediated insulin resistance (Yuan et al., xref )."

23761785

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➶

sparser

"Aspirin, salicylate, and sulindac can directly bind and inhibit recombinant IKKβ, the upstream positive regulator of NF-κB ( xref )."

23875171

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sparser

"In the present study, we wished to test the hypothesis that sodium salicylate, which inhibits IKKbeta , prevents hepatic insulin resistance caused by short-term elevation of FFA."

17951543

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sparser

"Lastly, direct inhibition of IKKβ by aspirin, salicylate, and sulindac may be another mechanism that could account for the antiproliferative effects of these NSAIDs via downregulation of NF-κB-mediated proliferative genes such as interleukin-2 (IL-2), granulocyte-macrophage colony-stimulating factor (GM-CSF), c-myc, cyclin D1, and COX-2, among others."

23875171

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"Salicylate inhibits IKK beta in concentrations that are achievable with dose schedules traditionally used in treating rheumatoid arthritis (3-4.5 g daily); indeed, this is likely to be the mechanism responsible for salicylate's utility in this disorder."

20080359

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➶

sparser

"The importance of NF-κB in the induction of insulin resistance is apparent in the improvements in insulin sensitivity resulting from inhibition of IKKβ by high dose salicylate [ xref ]."

19922415

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➶

sparser

"Because salicylates inhibit IKKβ [55,56] , Shoelson proposed that the hypoglycemic effects of these compounds might be due to inhibition of the NF-κB system."

12393301

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➶

sparser

"Insulin resistance was improved by systemic neutralization of IL-6 or salicylate inhibition of IKK-beta."

15685173

Resveratrol affects JUN

| 11

Resveratrol inhibits JUN. 11 / 11

| 11

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reach

"Retinal activator protein-1 activation, up-regulated following light exposure, was significantly reduced by application of resveratrol."

20709795

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reach

"To further verify that acetylation decreasing of c-Jun induced by reseveratrol is dependent on Sirt1, we treated T cells isolated from Sirt1 +/+ and Sirt1 -/- mice with resveratrol, and c-Jun were precipitated with anti-c-Jun antibody, then blotted with anti-acetylation antibody and anti-c-Jun antibody, we found that acetylation of c-Jun was significantly decreased in Sirt1 +/+ T cells treated with resveratrol, compared with that in non treated wild type T cells."

24073240

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"The combination of ursolic acid + resveratrol inhibited TPA induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds."

26100520

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reach

"In addition, resveratrol prevented TPA induced DNA binding of activator protein-1 (AP-1)."

15630167

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➶

reach

"In monocytic cells, resveratrol induced a miR-663-dependent effect targeting activator protein-1 (AP-1) through the Jun signaling pathway."

22683846

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reach

"It can be seen in the Western blot analysis that resveratrol as well as piceatannol (curcumin-group) and BTB14431 as well as JFD02836 (emodin-group) induced a significant reduction of endogenous c-Jun in a dose dependent manner."

16083495

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➶

reach

"Resveratrol suppresses TNF induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis : potential role of reactive oxygen intermediates and lipid peroxidation."

10843709

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➶

reach

"Resveratrol inhibits the activation of CREB, c-jun, AP-1 and NF-kB transcription factors."

19597034

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➶

reach

"Myricetin, but not resveratrol, attenuated tumor promoter induced activation of c-fos or activator protein-1."

19325788

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➶

reach

"Myricetin, but not resveratrol, attenuated tumor promoter induced activation of c-fos or activator protein-1."

17693661

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➶

reach

"Resveratrol, which also act as an AhR-antagonist (but may also interfere with NOX signaling and scavenge ROS), suppressed PM 10 -induced CYP1B1 and c-Jun responses, but not IL-6 or CXCL8 in A549 epithelial cells, suggesting that the latter were induced through AhR independent mechanisms [XREF_BIBR]."

26147224

Methylene blue affects CASP1

| 11

Methylene blue inhibits CASP1. 11 / 11

| 11

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"Based on a previous report 17, we speculate that MB inhibits the activity of caspase-1 by oxidizing the catalytic cysteine."

28963531

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➶

reach

"Methylene blue also inhibited recombinant Casp1 and Casp3."

26400108

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➶

reach

"Methylene blue attenuates mitochondrial ROS production, phagocytosis, caspase 1 activity, and NLRP3 promoter activity."

28963531

---

➶

reach

"As the result, MB dose-dependently attenuated secretion of IL-1beta (p17) and caspase-1 (p20) as well as aggregation of Asc."

28963531

---

➶

reach

"MB treatment at the 1 st step blocked secretion of IL-1beta, IL-18, and caspase-1, implying that MB interrupts priming of inflammasome activation."

28963531

---

➶

reach

"Furthermore, MSU crystals, another NLRP3 inflammasome trigger, induced caspase-1 and IL-1beta secretion, which were blocked by MB treatment."

28963531

---

➶

reach

"dsDNA- and Listeria mediated IL-1beta and caspase-1 secretions were significantly blocked by MB co-treatment."

28963531

---

➶

reach

"Furthermore, caspase-1 pathway is downregulated by MB."

32326607

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➶

reach

"MB, together with its derivatives (metabolites), azure A and azure B, is able to stimulate protein degradation and inhibit oxidative damage [XREF_BIBR] and also inhibit the activity of caspase-1 and caspase-3 [XREF_BIBR]."

26751493

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➶

reach

"Furthermore, MB reduced the activity of caspase-1."

28963531

---

➶

reach

"As the result, MB attenuated caspase-1 and IL-1beta secretion resulting from LPS or E.coli-mediated non canonical inflammasome activation."

28963531

Lipopolysaccharide affects JUN

| 11

Lipopolysaccharide inhibits JUN. 11 / 11

| 11

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➶

reach

"By inhibiting phosphorylation and nuclear translocation of Jun, HTMC suppressed LPS induced activator protein-1 (AP-1) activation."

26852953

---

➶

reach

"In human THP-1 monocytic cells and human blood monocytes, resveratrol upregulates miR-663 expression [XREF_BIBR, XREF_BIBR]; miR-663 decreases endogenous activator protein-1 (AP-1) activity and impairs lipopolysaccharide (LPS) induced upregulation of AP-1in THP-1 cells, in part, by directly targeting Jun B and Jun D transcripts [XREF_BIBR]; miR-663 is further involved in a resveratrol related pathway through targeting transforming growth factor-beta1 [XREF_BIBR]."

23870168

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➶

reach

"In THP-1 cells, miR-663 decreases endogenous activator protein-1 (AP-1) activity and impairs lipopolysaccharide (LPS) induced upregulation of AP-1 by, in part, by directly targeting the Jun B and Jun D transcripts."

21518431

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➶

reach

"The results obtained by electrophoretic mobility shift assay (EMSA) demonstrated a concentration dependent reduction of the LPS stimulated activation of NF-kappaB and activator protein-1 (AP-1) by lirioresinol B dimethyl ether in in vitro and in vivo models."

31129419

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➶

reach

"In THP-1 cells, miR-663 decreases endogenous activator protein-1 (AP-1) activity and impairs lipopolysaccharide (LPS) induced upregulation of AP-1 by, in part, by directly targeting the Jun B and Jun D transcripts."

21518431

---

➶

reach

"JNK inhibition with SP600125 blocked LPS induced c-Jun activity, which is a direct and specific downstream target of JNK activity."

23034047

---

➶

reach

"KB-34, a newly synthesized chalcone derivative, inhibits lipopolysaccharide stimulated nitric oxide production in RAW 264.7 macrophages via heme oxygenase-1 induction and blockade of activator protein-1."

19174156

---

➶

reach

"Activated GR inhibited LPS induced activator protein 1 activity, which in turn decreased activating transcription factor 2/c-Jun phosphorylation."

18945810

---

➶

reach

"Wogonoside inhibits inflammatory cytokine production in lipopolysaccharide stimulated macrophage by suppressing the activation of the JNK and c-Jun signaling pathway."

32411755

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➶

reach

"ATA not only inhibited nuclear factor-kappaB (NF-kappaB) activation through impairment of the targeting and degradation of IkappaBs but also reduced LPS induced activator protein-1 (AP-1) activation."

12065759

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➶

reach

"In human THP-1 monocytic cells and human blood monocytes, resveratrol upregulates miR-663 expression [XREF_BIBR, XREF_BIBR]; miR-663 decreases endogenous activator protein-1 (AP-1) activity and impairs lipopolysaccharide (LPS) induced upregulation of AP-1in THP-1 cells, in part, by directly targeting Jun B and Jun D transcripts [XREF_BIBR]; miR-663 is further involved in a resveratrol related pathway through targeting transforming growth factor-beta1 [XREF_BIBR]."

23870168

Hydroxychloroquine affects NLRP3

| 11

Hydroxychloroquine inhibits NLRP3. 11 / 11

| 11

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➶

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"Thus, HCQ appears to inhibit NLRP3 inflammasome activation by down-regulating CTSB and CTSL activity."

29500339

---

➶

reach

"Thus, we hypothesized that HCQ inhibits NLRP3 inflammasome activation by downregulation of CTS activity."

29500339

---

➶

reach

"These data suggested that HCQ blocks NLRP3 inflammasome activation by reducing CTSB and CTSL activity."

29500339

---

➶

reach

"Mechanistic studies showed that HCQ could inhibit the priming of the NLRP3 inflammasome by down-regulating I/R or H/R induced NF-kappaB signaling."

29500339

---

➶

reach

"To further confirm whether HCQ suppresses NLRP3 inflammasome activation through reduction of CTSB and CTSL activity, we compared the effects of HCQ and Ca074Me on H/R induced HK-2 cell injury and NLRP3 inflammasome activation."

29500339

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➶

reach

"Next we sought to determine the mechanism through which HCQ inhibits NLRP3 inflammasome activation."

29500339

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➶

reach

"HCQ inhibits NLRP3 inflammasome activation in vivo and in vitro."

29500339

---

➶

reach

"Our data had provided a new insight into the mechanism through which HCQ inhibits the activation of NLRP3 inflammasome."

29500339

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➶

reach

"Additionally, HCQ markedly reduced macrophage and neutrophil infiltration, pro inflammatory cytokine production, and NLRP3 inflammasome activation."

29500339

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➶

reach

"Results : In vitro studies demonstrated that HCQ attenuated activation of the NLRP3 inflammasome and blocked LMP."

31556748

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➶

reach

"XREF_FIG), and mRNA levels of IL-1beta, IL-6, TNF-alpha, and MCP-1 in HCQ group and HCQ+C a074Me group also showed no statistical significance, which confirmed that HCQ suppresses NLRP3 inflammasome through downregulation of CTSB and CTSL activity."

29500339

Carbon monoxide affects NLRP3

| 11

Carbon monoxide inhibits NLRP3. 11 / 11

| 11

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"Taken together, these findings indicate that CORM3, and potentially inhalable CO, inhibits activation of the NLRP1 and NLRP3 inflammasomes."

30651220

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➶

reach

"Our results suggest that CO negatively regulates NLRP3 inflammasome activation by preventing mitochondrial dysfunction."

25770182

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➶

reach

"Carbon Monoxide Inhibited NLRP3 Inflammasome Activation of AKI in Septic Rats."

26334271

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➶

reach

"In our study, CO inhibited the NLRP3 inflammasome activation and decreased the sepsis induced AKI in rats."

26334271

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➶

reach

"Previous studies suggested that NLRP3 inflammasome activity is positively regulated by ROS [XREF_BIBR, XREF_BIBR], so CO may inhibit NLRP3 inflammasome activation by decreasing ROS levels in kidney of sepsis induced AKI."

26334271

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reach

"The present study provides a basis for the use of CORM-2 as an effective strategy to protect against sepsis induced AKI, and exogenous CO as released by CORM-2 treatment decreases the oxidative stress and NLRP3 inflammasome activation."

26334271

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➶

reach

"Exogenous Carbon Monoxide Decreases Sepsis Induced Acute Kidney Injury and Inhibits NLRP3 Inflammasome Activation in Rats."

26334271

---

➶

reach

"Therefore, CO may also inhibit NLRP3 inflammasome activation by increasing NO levels in sepsis induced AKI."

26334271

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➶

reach

"CO also inhibits NLRP3 inflammasome activation XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."

28378932

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➶

reach

"Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages."

25770182

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➶

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"In the case of the former, CO released by CORM-3 is proposed to inhibit the activation of the NLRP3 inflammasome in cardiac fibroblasts preventing myocardial apoptosis."

30158958

N'-(1,8-dimethyl-4-imidazo[1,2-a]quinoxalinyl)ethane-1,2-diamine affects IKBKB

10 | 1

N'-(1,8-dimethyl-4-imidazo[1,2-a]quinoxalinyl)ethane-1,2-diamine inhibits IKBKB. 11 / 11

10 | 1

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"Next, we tested several small molecule inhibitors targeting NFkB signaling at different stages and identified that BMS345541 (Inhibitor of IKKbeta at IC50 0.4 muM and IKKalpha at IC50 4muM) inhibits GD2 and GD3S expression in TNBC cells [XREF_BIBR]."

28858852

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No evidence text available

27017554

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No evidence text available

21087862

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No evidence text available

19267461

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No evidence text available

17197177

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No evidence text available

21708416

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No evidence text available

17850214

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No evidence text available

17540562

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No evidence text available

22037378

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No evidence text available

15975507

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No evidence text available

20044255

Butyric acid affects STAT1

1 | 3 7

Butyric acid inhibits STAT1. 10 / 10

| 3 7

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➶

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"ATRA as well as PMA abolished the degradation of STAT1 by butyrate but not by staurosporine, indicating that differentiation specifically desensitizes cells against butyrate."

24810717

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➶

reach

"Whereas butyrate reduces STAT1 in leukemia cells, most solid tumor derived cells show an induction of STAT1 after treatment (XREF_SUPPLEMENTARY)."

24810717

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➶

reach

"Butyrate effectively inhibited IFN-gamma-induced STAT1 activation, resulting in inhibition of iNOS upregulation in human colon epithelial and carcinoma cells in vitro."

22517765

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➶

medscan

"Whereas butyrate reduces STAT1 in leukemia cells (Figure ), most solid tumor-derived cells show an induction of STAT1 after treatment ( )."

24810717

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➶

reach

"Furthermore, butyrate suppressed IFN-gamma-mediated inflammation in colon epithelial cells by preventing STAT-1 activation and blocking iNOS induction [XREF_BIBR]."

24876678

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➶

reach

"We did some additional tests to clarify whether other proteases contribute to the degradation of STAT1 in NB4 cells treated with butyrate."

24810717

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➶

reach

"This effect begins after 12 hours of treatment, indicating that the butyrate induced STAT1 loss is most likely an indirect effect."

24810717

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➶

reach

"Butyric acid was also demonstrated to effectively inhibit STAT1 activation by reducing IFN-gamma production, which results in the apoptosis of T cells of unspecified type and the suppression of the inflammation [XREF_BIBR]."

28702095

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➶

medscan

"Next, we investigated at which concentrations butyrate reduces STAT1 protein expression and whether this process can be correlated with the induction of apoptosis."

24810717

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medscan

"A) Sodium butyrate (NaB) downregulates the expression of STAT1, but not STAT2 and STAT3 during apoptosis."

24810717

Butyric acid inhibits STAT1. 1 / 1

1 |

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➶

bel

"inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma-induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation."

15123634

Ruxolitinib phosphate affects TYK2

10 |

Ruxolitinib phosphate inhibits TYK2. 10 / 10

10 |

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No evidence text available

21106455

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No evidence text available

24461299

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No evidence text available

22698084

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No evidence text available

24417533

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No evidence text available

23668484

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No evidence text available

23061660

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No evidence text available

26927423

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No evidence text available

29298069

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No evidence text available

22591402

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tas

No evidence text available

22037378

Phorbol 13-acetate 12-myristate affects NFKBIA

| 10

Phorbol 13-acetate 12-myristate inhibits NFKBIA. 10 / 10

| 10

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➶

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"Curcumin substantially reduced the fluoride- and TPA induced IkappaBalpha degradation (XREF_FIG) and abolished the p65 phosphorylation, as assessed in cell lysates (XREF_FIG) and p65 translocation to the nuclei (XREF_FIG) after exposure to both agents."

25540590

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reach

"In XREF_FIG, the time courses for fluoride- and TPA induced IkappaBalpha degradation are presented."

25540590

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➶

reach

"TNF-alpha- or TPA induced IkappaBalpha kinase (IKK) activation was also blocked by these inhibitors, which slightly reversed TNF-alpha-induced but completely reversed TPA induced IkappaBalpha degradation."

12645577

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reach

"As expected, TPA increased IKBalpha degradation (Additional file XREF_SUPPLEMENTARY : Figure S1B) and induced binding of p65 to kappaB-RE of MnSOD gene."

24047462

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➶

reach

"Although protocatechuic acid decreased p65-DNA binding, it did not affect TPA stimulated degradation of IkappaBalpha."

20026373

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reach

"Activation of NF-kappaB is usually associated with the induction of IkappaB phosphorylation; as expected, TPA enhanced the activation of serine 536 phosphorylated NF-kappaB p65 and serine32 phosphorylated I-kappaBalpha and caused the degradation of IkappaBalpha in ECV304 cells (XREF_FIG)."

27654969

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➶

reach

"The results showed that galangin blocked TPA induced IkappaBalpha degradation by inhibiting the phosphorylation of IkappaBalpha."

25698902

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➶

reach

"In addition, bicyclol attenuated TPA induced IkappaB-alpha degradation."

15994005

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➶

reach

"Capsaicin pretreatment significantly suppressed TPA induced degradation of IkappaB-alpha, thereby attenuating nuclear translocation of p65."

11179825

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reach

"However, some carcinogens, e.g., DMBA and 12-O-tetra-decanoylphorbol-13-acetate (TPA), degrade IkappaBalpha by its phosphorylation."

19823771

Parthenolide affects NLRP3

| 2 8

Parthenolide inhibits NLRP3. 10 / 10

| 2 8

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"Glyburide and parthenolide both inhibited NLRP3 activation by LPS and ATP (data not shown)."

22216309

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➶

reach

"Previous studies have reported that MNS, parthenolide, BAY 11-7082, and INF39 can inhibit the ATPase activity of NLRP3 and show inhibitory activity for NLRP3 inflammasome in vitro."

29021150

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"IL-1beta secretion was not affected by treatment with the NLRP3 inhibitor glyburide XREF_BIBR or parthenolide, which has also been shown to inhibit NLRP3 XREF_BIBR."

22216309

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➶

eidos

"OLT1177 , BOT-4-one , parthenolide , BAY 11-7082 , INF39 , and MCC950 could inhibit ATPase activity of NLRP3 ."

| DOI

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➶

reach

"A few NLRP3 inflammasome inhibitors, including sulforaphane, isoliquiritigenin, beta-hydroxybutyrate (BHB), flufenamic acid, mefenamic acid, 3,4-methylenedioxy-beta-nitrostyrene (MNS), parthenolide, BAY 11-7082, INF39, and MCC950, have been developed, but there is no evidence showing that these compounds can specifically and directly inhibit NLRP3 itself."

29021150

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➶

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"Interestingly, in addition to its role in inhibiting caspase-1, parthenolide also directly inhibits NLRP3 by inhibiting its ATPase activity, which is required for activation of caspase-1."

25653548

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➶

reach

"Parthenolide, BAY 11-7082, INF39, and MNS have been reported to directly inhibit NLRP3 ATPase activity, but these inhibitors have unspecific roles."

29021150

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➶

eidos

"OLT1177 , BOT-4-one , parthenolide , BAY 11-7082 , INF39 , and MCC950 could inhibit ATPase activity of NLRP3 ."

32693241

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reach

"The underlying mechanisms of action of these molecules are diverse : BHB and glyburide prevent the decline of intracellular K + required for NLRP3 activation and ASC oligomerization XREF_BIBR, XREF_BIBR, whereas parthenolide and Bay 11-7082 inhibit NLRP3 ATPase activity 18."

30894604

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➶

reach

"However, previously identified NF-kappaB inhibitors Bay 11-7082 and parthenolide were also shown to inhibit the second step of NLRP3 inflammasome activation [XREF_BIBR]."

27467658

Ouabain affects JAK1

| 10

Ouabain inhibits JAK1. 10 / 10

| 10

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➶

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"A. Ndfip1 / 2 mediated the ouabain induced JAK1 deregulation ."

| PMC

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➶

eidos

"Deregulation of JAK1 by ouabain induced proteolysis was mediated by Ndfip1 / 2 and E3 ligase NEDD4 A few ubiquitination proteases and phosphatases have been reported to mediate JAK1 degradation [ 25 ] , [ 26 ] , [ 27 ] , including Ndfip1 / 2 by activation of the proteolysis ligase NEDD4 [ 25 ] ."

| PMC

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➶

eidos

"Herein , we knocked down the expression of either Ndfip1 or Ndfip2 ( Figure 6 A ) and found that depletion of either was able to significantly restore the downregulated JAK protein level caused by ouabain treatment ( Figure 6B ) Furthermore , the NEDD4 inhibitor Heclin was also able to significantly rescue the ouabain downregulated JAK1 in a dose dependent manner ( Figure 6C ) ."

| PMC

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➶

eidos

"We thus examined these potential effectors and found that Ndfip1 / 2 may mediate the ouabain induced JAK1 deregulation ."

| PMC

---

➶

eidos

"Therefore , JAK1 diminishment by ouabain is not associated with Na + / K + - ATPase ."

| PMC

---

➶

eidos

"C. NEDD4 inhibitor Heclin restored the ouabain downregulated JAK1 ."

| PMC

---

➶

eidos

"Ouabain induced JAK1 degradation through ubiquitination mediated proteolysis ."

| PMC

---

➶

eidos

"Moreover , this Ndfip1 / 2 and NEDD4 mediated JAK1 diminishment by ouabain is endogenous , because ouabain and other natural cardenolides downregulated JAK1 regardless of whether or not the ST or HCT-8 cells were infected by coronaviruses ( Figures 1 & 2 ) ."

| PMC

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➶

eidos

"JAK1 diminishment by ouabain for mediating TGEV inhibition is independent of Na + / K + - ATPase ."

| PMC

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➶

eidos

"Since Na + / K + - ATPase is the perceptive pharmacological target of ouabain [ 18 ] , [ 19 ] , [ 20 ] , we first dissected whether JAK1 diminishment by ouabain was associated with Na + / K + - ATPase ."

| PMC

Morphine(1+) affects FOS

| 10

Morphine(1+) inhibits FOS. 10 / 10

| 10

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"The present data show that morphine suppresses the induction of c-fos."

2110636

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➶

reach

"Previous studies have shown that the morphine mediated c-Fos response is attenuated by antagonists of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor."

11275410

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➶

reach

"Presley, R. W., MenBtrey, D., Levine, J. D. and Basbaum, A. I. Systemic morphine suppresses noxious stimulus evoked fos protein like immunoreactivity in the rat spinal cord."

7902962

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➶

reach

"Moreover, c-Fos in regions of the accumbens core matrix with low MOP receptor immunoreactivity was reduced by morphine pretreatment."

19705550

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➶

reach

"The stress induced c-fos induction was markedly decreased by a moderate (10 mg/kg) dose of morphine."

12225868

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➶

reach

"Unlike cocaine, which increases Fos protein expression in the habenula, chronic morphine exposure reduces c-fos activity in the MHb."

24734015

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➶

reach

"Chronic morphine administration reduces c-fos activity in the MHb, whereas cocaine promotes c-fos expression in the LHb."

30873055

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reach

"In the CPu of beta-FNA treated rats, morphine induced c-Fos and JunB were attenuated compared to vehicle infused rats."

10526114

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"In this study, intrathecal injection of morphine (10 mug), endomorphin-2 (5 mug) and Dmt-endomorphin-2 (10 mug) significantly decreased a number c-Fos positive neurons in the laminae I - III in the spinal cord by about 40%, 30% and 40%, respectively."

12759135

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"Morphine (10 mg.kg (-1)) or the TRPA1 channel blocker HC-030031 (300 mg.kg (-1)) inhibited the spinal c-Fos response to AITC, in control and DSS pretreated animals, whereas the response to intracolonic capsaicin (5%) was blocked by morphine but not HC-030031."

20590633

Isotretinoin affects JUN

| 10

Isotretinoin inhibits JUN. 10 / 10

| 10

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"Desbois C., Aubert D., Legrand C., Pain B. and Samarut J. : A novel mechanism of ~ Lction for v-erbA : abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors."

7734399

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➶

reach

"A novel mechanism of action for v-ErbA : abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors."

1682056

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➶

reach

"A novel mechanism of action for v-ErbA : abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors."

7903219

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➶

reach

"A novel mechanism of action for v-ErbA : abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors."

8453668

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➶

reach

"Our previous studies in ferrets (Mustela putorius furo), an excellent model for studying carotenoid absorption and metabolism, showed that cigarette smoke exposure decreased levels of retinoic acid and retinoic acid receptor beta (RARbeta) protein, but increased levels of c-Jun and cyclin D1 proteins, and induced precancerous lesions in lung tissue [XREF_BIBR, XREF_BIBR]."

21665318

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➶

reach

"A novel mechanism of action for v-ErbA : abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors."

8324824

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➶

reach

"Lee and colleagues demonstrated in vitro that retinoic acid inhibited Jun N-terminal kinase (JNK), which phosphorylates and thus activates c-Jun, and that the inhibitory effect of retinoic acid on JNK activity was through the induction of mitogen activated protein (MAP) kinase phosphatase 1 (MKP-1) [XREF_BIBR, XREF_BIBR]."

21665318

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➶

reach

"In addition, we show that IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate transiently induce c-jun and c-fos expression and that retinoic acid inhibits IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate induction of c-fos, but not c-jun."

2178224

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➶

reach

"More specifically, retinoic acid or retinoic acid analogs are able to inhibit ATF2 [XREF_BIBR] and c-Jun [XREF_BIBR]."

26516076

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➶

reach

"Endocrinology 114, 293-295 11 Desbois C, Aubert D, kegrand C, Pain B, Samarut J (1991) A novel mechanism of action of v-ErbA : Abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors."

8241960

Fenofibrate affects RELA

2 | 8

Fenofibrate inhibits RELA. 10 / 10

2 | 8

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"Although other downstream target genes of fenofibrate may also take part in modulating apoptosis, the present data demonstrated that fenofibrate could potentiate chemosensitivity to human breast cancer by suppressing the activation of AKT and NF-kappaB p65 signaling pathway at least partially, which served a prominent function as an activator in apoptosis by downregulating Mcl-1 and Bcl-xl and upregulating Bok and Bax."

30774365

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➶

ctd

No evidence text available

25545733

---

➶

reach

"We demonstrated that fenofibrate markedly inhibited the activation of the NF-κ B p65 pathway in the lungs and intestines of mice during intestinal I/R injury, while the Iκ Bα activity was up-regulated compared to the vehicle group, unveiling that the anti-inflammatory property of fenofibrate in the intestinal I/R injury is through an NF-κ B p65 dependent pathway."

26902261

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➶

reach

"Also, fenofibrate treatment decreased NF-kappaB p65 and cyclooxygenase 2 proteins in aortas."

30296701

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➶

reach

"Fenofibrate prevented nuclear translocation of nuclear factor of activated T-cells c4 (NFATc4) and p65 subunit of nuclear factor-kappa B (p65-NFkappaB) induced by pressure overload or angiotensinII (AngII)."

23518069

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➶

reach

"XREF_TABLE and XREF_FIG showed that fenofibrate could significantly inhibit the up-regulation of NF-kappaB p50 and p65 proteins of EAM rats (p < 0.05)."

27095924

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➶

reach

"Furthermore, they proved that fenofibrate inhibited the transcriptional activity of NF-kappaB and RelA and disrupted the association of RelA and HIF1alpha, leading to the decreased PKM2 expression and mitochondrial impairment XREF_BIBR."

29760790

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➶

ctd

No evidence text available

20520642

---

➶

reach

"Fenofibrate downregulated p-IKKa/b, p-IkappaBa, and nuclear NFkappaB (p65 and p50), which are involved in the NF-kappaB pathway, and upregulated AMPK related proteins, such as LKB1, p-AMPKalpha, p-AMPKbeta1, and AMPKgamma1."

29760790

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➶

reach

"We demonstrated that fenofibrate markedly inhibited the activation of the NF-kappaB p65 pathway in the lungs and intestines of mice during intestinal I/R injury, while the Ikappa Balpha activity was up-regulated compared to the vehicle group, unveiling that the anti-inflammatory property of fenofibrate in the intestinal I/R injury is through an NF-kappaB p65 dependent pathway."

26902261

Ethanol affects CASP1

| 1 2 7

Ethanol inhibits CASP1. 10 / 10

| 1 2 7

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➶

medscan

"Ethanol inhibits the activation of IL-1β and caspase-1."

24244322

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➶

reach

"And, similar to J774 cells, ethanol treatment prevented the cleavage and secretion of both IL-1beta and caspase-1 from human PBMCs (XREF_FIG)."

27421477

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➶

reach

"Ethanol Inhibits Activation of Caspase-1."

24244322

---

➶

reach

"The additional application of EtOH to sodium orthovanadate at the first time point significantly decreased the caspase-1 activity, but less so than EtOH does in the LPS and ATP group."

32366053

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➶

medscan

"Ethanol inhibits the activation of the NLRP3 inflammasome, thereby reducing the activation of caspase-1 and the secretion of mature IL-1β at two levels: 1) by inhibiting the release of cathepsin B from both the intact and disrupted lysosomes, and 2) by diminishing the assembly of the NLRP3 inflammasome complexes."

24244322

---

➶

reach

"These findings suggest that ethanol inhibits the autoproteolysis of caspase-1 by inhibiting the activation of inflammasome."

24244322

---

➶

reach

"In addition, alcohol reduced pro caspase 1 but promoted caspase 1 activation in mice with tumors."

29245988

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➶

eidos

"Ethanol Diminishes Caspase-1 Activity and ASC Speck Formation In order to investigate the influence of ethanol on caspase-1 activation , EtOH was applied to HepG2 cells at two different time points to determine its mechanistical approach ."

32366053

---

➶

reach

"In line of this hypothesis, here we found that ethanol induced activation of Caspase-1, as well as cleavage of IL-1beta were attenuated in livers of MyD88 LysM-KO mice, suggesting that Myeloid-MyD88 contributes to ethanol induced liver injury through induction of pyroptosis."

28165624

---

➶

reach

"Ethanol prevents the cleavage of pro-IL-1beta and pro-caspase-1 into their mature forms."

27421477

Butyric acid affects NLRP3

| 10

Butyric acid inhibits NLRP3. 10 / 10

| 10

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➶

reach

"In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes."

29475132

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➶

reach

"We report that BHB, but neither acetoacetate nor structurally related short chain fatty acids, butyrate and acetate, suppresses activation of the NLRP3 inflammasome in response to several structurally unrelated NLRP3 activators, without impacting NLRC4, AIM2 or non canonical caspase-11 inflammasome activation."

25686106

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➶

reach

"Sodium butyrate has a similar chemical structure to HBA and also has been reported to inhibit the NLRP3 pathway [XREF_BIBR]."

28273882

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➶

reach

"There is evidence that ketone bodies, beta-hydroxybutyrate (BHB), but not acetoacetate (AcAc) or the structurally related SCFAs, butyrate and acetate, suppress activation of the Nlrp3 inflammasome in response to urate crystals, ATP and lipotoxic fatty acids XREF_BIBR, XREF_BIBR."

29475132

---

➶

reach

"In colon, butyrate inhibited NLRP3 inflammasome activation via GPR109A."

31347703

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➶

reach

"Conclusions : Sodium butyrate can inhibit the activation of NLRP3 inflammasome and decrease the production of IL-1beta and IL-18 in intestinal mucosa of severe scald mice, which protects the intestinal barrier function by alleviating the alteration of tight junction protein expression and localization."

32023718

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➶

reach

"Sodium Butyrate and beta-Hydroxybutyric Acid Topical Treatment Inhibits Activation of NLRP3 Inflammasome in Alkali Injured Corneas."

28273882

---

➶

reach

"Recently the ketone body, beta-hydroxy butyrate (BHB), was shown to efficiently inhibit the NLRP3 inflammasome in macrophages, and in vivo models of inflammatory disease."

28836226

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➶

reach

"A study by Youm et al. showed that the NLRP3 inflammasome activation was inhibited by the ketone body beta-hydroxybutyrate (BHB) but not by acetoacetate or by related short-chain fatty acids butyrate and acetate [XREF_BIBR]."

27942750

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➶

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"For example, Wang et al. reported that sodium butyrate treatment can efficiently inhibit Nlrp3 inflammasome activation and thereby inhibits obesity induced inflammation, indicating that NaB might be a potential anti-inflammatory agent for obesity in db/db mice XREF_BIBR."

29475132

Bortezomib affects NFKB1

2 | 8

Bortezomib inhibits NFKB1. 10 / 10

2 | 8

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➶

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"Bortezomib also effectively induced degradation of the p105 and p50 subunits of NF-kappaB in a dose dependent manner (XREF_FIG)."

| PMC

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➶

ctd

No evidence text available

17164350

---

➶

reach

"After treatment, bortezomib had up-regulated DIABLO and NFkBIB (NF-kB inhibitor), and down-regulated the NF-kB1, NF-kB2, and BIRC1, an anti-apoptotic gene (XREF_FIG)."

25913414

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➶

ctd

No evidence text available

12893773

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➶

reach

"Furthermore, inhibition of pan-caspases abolished Bortezomib induced degradation of p65, p105 and Sp proteins, but not that of IkappaBalpha."

| PMC

---

➶

reach

"This is the first report showing degradation of p105 by Bortezomib."

| PMC

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➶

reach

"In preclinical mesothelioma models, the proteasome inhibitor bortezomib inhibits constitutive activation of NFkB and enhances the cytotoxicity of cisplatin and pemetrexed [XREF_BIBR, XREF_BIBR]."

18770046

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➶

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"They showed that proteasome inhibitor bortezomib more effectively inhibited nuclear localization of RELA and p50 than cREL or alternate pathway subunits NF-kappaB2 or RELB in tumor specimens and lines from patients with HNSCC."

18694378

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➶

reach

"Besides IkappaBalpha and p65, we also observed degradation of p105 by Bortezomib in a dose- and time dependent manner."

| PMC

---

➶

reach

"These studies show that bortezomib reduces blood proteasome activity by 77% and also reduces NFKB and eNOS (nitric oxide synthase) expression following harmful ischemia."

19181875

[11C]-SORAFENIB affects MAPK14

10 |

[11C]-SORAFENIB inhibits MAPK14. 10 / 10

10 |

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➶

tas

No evidence text available

19654408

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➶

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No evidence text available

19962319

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➶

tas

No evidence text available

18183025

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➶

tas

No evidence text available

15711537

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➶

tas

No evidence text available

17850214

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

20621496

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➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

25778995

---

➶

tas

No evidence text available

18077425

Shikonin affects NLRP3

| 10

Shikonin inhibits NLRP3. 10 / 10

| 10

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➶

reach

"Shikonin decreased NLRP3 inflammasome activation in response to nigericin more potently than acetylshikonin."

27467658

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➶

reach

"In the present study we showed that shikonin inhibits NLRP3 inflammasome activation by acting on both signals."

27467658

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"As the recruitment of adaptor protein ASC and activation of caspase-1 are common to several inflammasomes including the AIM2 inflammasome, we were interested whether shikonin specifically inhibits NLRP3 inflammasome."

27467658

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"We demonstrated that shikonin at non toxic concentrations inhibits NLRP3 inflammasome activation by nigericin."

27467658

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reach

"Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1."

27467658

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reach

"Based on its reported antipyretic and anti-inflammatory properties, we investigated whether shikonin suppresses the activation of NLRP3 inflammasome."

27467658

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"Correction : Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1."

27657699

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reach

"We further showed that shikonin suppresses NLRP3 dependent maturation of IL-1beta induced by soluble as well as particulate triggers."

27467658

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"Our results demonstrate that shikonin inhibits NLRP3 inflammasome activation independently of the NLRP3 trigger used, suggesting that it acts at downstream stages of inflammasome activation."

27467658

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reach

"To determine whether shikonin specifically inhibits NLRP3 inflammasome in response to nigericin or has broader action, we tested its inhibitory capacity in treatment with various NLRP3 inflammasome activators."

27467658

S-Ruxolitinib affects TYK2

10 |

S-Ruxolitinib inhibits TYK2. 10 / 10

10 |

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No evidence text available

22698084

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22037378

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26927423

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24417533

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24461299

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21106455

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23061660

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22591402

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No evidence text available

23668484

3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]propanenitrile affects TYK2

10 |

3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]propanenitrile inhibits TYK2. 10 / 10

10 |

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No evidence text available

23668484

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No evidence text available

21106455

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26927423

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23061660

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24417533

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22698084

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22037378

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No evidence text available

24461299

Lipopolysaccharide affects TICAM1

| 10

Lipopolysaccharide inhibits TICAM1. 9 / 9

| 9

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"Moreover, deficiency of ATG7, which is an essential E1 ligase for LC3B-II formation, inhibited poly (I : C) - and LPS induced degradation of TRIF (XREF_FIG)."

28898289

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➶

reach

"Taking together these results are consistent with data obtained using microarray technology and functional analyses were LPS triggered TRIF dependent signaling was blocked when DMPO is added to culture medium."

29589052

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reach

"Poly (I : C) or LPS stimulation causes a rapid and dramatic degradation of TRIF to avoid sustained activation of TRIF and expression of type I IFNs and inflammatory cytokines."

28898289

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reach

"Regarding TLR4 and TRIF signaling, LPS treatment reduces H5N1 influenza virus replication and lethality in a TRIF dependent manner XREF_BIBR."

24595131

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reach

"TRIF (Toll/IL -1 receptor domain containing adaptor protein inducing IFN-beta), of the MyD88 independent endocytosis pathway, was decreased by LPS (0.72 x, p <.05) and did not respond to nPM (not shown)."

28410596

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reach

"Similar to CD4+ cells, the percent of CD4 negative Vbeta3 T cells producing IFN-gamma was at least 30 percent lower in the TRIF deficient mice treated with LPS (XREF_FIG)."

19380779

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reach

"Interestingly, TRIM32 promotes TRIF degradation via the selective instead of the classical autophagic pathway, since deficiency of components of the selective but not classical autophagic pathway inhibited TRIM32 mediated, as well as poly (I : C) - and LPS induced degradation of TRIF."

28898289

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"LPS induced survival was also inhibited by lentiviruses encoding dnMyD88 or a truncated TRIF (Toll and interleukin-1R homologous domain containing adapter protein inducing interferon-beta) molecule, whilst, in contrast, neutrophil survival was enhanced by overexpression of kinase mutated interleukin-1 receptor associated kinase 1 (kmIRAK-1), which activated nuclear factor (NF)-kappaB."

19175800

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"On the other hand, LPS treatment down-regulated IRF3, TBK1 and TRIF in 4F treated MDMs compared to vehicle pre-treatment."

22982462

Lipopolysaccharide bound to TLR4 receptor inhibits TICAM1. 1 / 1

| 1

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"LPS is a component of the outer membrane of Gram negative bacteria and specifically binds to the TLR4 receptor, triggering both the downstream MyD88 and TRIF dependent pathways."

24244133

Tofacitinib affects STAT1

| 9

Tofacitinib inhibits STAT1. 9 / 9

| 9

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"Tofacitinib was also shown to inhibit STAT1, STAT3, STAT4, STAT5 and STAT6 activation in cultured anti-CD3-stimulated T cells, which suggests that targeting the cytokine signalling pathway with TKIs may be a consideration for immunosuppression 183."

23903221

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"They demonstrated that tofacitinib significantly decreased Signal Transducer and Activator of Transcription (STAT) 3, pSTAT1, Nuclear Factor (NF) kappaBp65 and induced Suppressor of Cytokine Signaling (SOCS) 53 and Protein Inhibitor Of Activated STAT (PIAS) 3 expression in the cells and explant cultures."

27022911

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"Tofacitinib is new agent, a selective inhibitor of Janus kinase (JAK) signaling pathways mediated by JAK1 and JAK3 and inhibits the key transcription factors STAT1 and STAT3."

28461107

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"XREF_BIBR In this study, tofacitinib inhibited pSTAT1, pSTAT3 and NFkappaBp65 in PsAFLS and PsA explants, an effect that was paralleled by induction of both SOCS3 and PIAS3."

26353790

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"At the maximum oral dose tested (i.e., 60mg/kg), tofacitinib inhibited pSTAT1 elevation by 74 +/-12% (mean +/-SEM)."

29225517

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"Through its ability to inhibit JAK1 activity, tofacitinib is able to block the activation of STAT3 and STAT1 downstream of IL-6 and STAT1 but not STAT4 activation downstream of IL-12 even at a high concentration of the inhibitor (500nM in vitro) [XREF_BIBR] In summary these changes are associated with a reduction in mouse Th1 and Th2 polarization and a reduction in the expression of inflammatory cytokines from both T cells and cells of the innate immune system [XREF_BIBR]."

23028408

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"Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis."

30728752

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reach

"1muM of Ruxolitinib (JAK1/2 inhibitor) and 5muM of Tofacitinib (JAK1/3 inhibitor) suppressed the IL-27-mediated STAT-1, -3 and -5 activation (XREF_SUPPLEMENTARY) without any significant change in cell viability (data not shown)."

28240310

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"Tofacitinib inhibited pSTAT1 and pSTAT3, with no effect on tSTAT1 or tSTAT3 compared with DMSO control (XREF_FIG B, D), pSTAT2 was undetectable."

26353790

Sodium(1+) affects IKBKB

| 9

Sodium(1+) inhibits IKBKB. 9 / 9

| 9

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"In the present study, we wished to test the hypothesis that sodium salicylate, which inhibits IKKbeta, prevents hepatic insulin resistance caused by short-term elevation of FFA."

17951543

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"High concentrations of sodium salicylate are known to mediate its anti-inflammatory property by inhibiting the cellular kinase IKK-beta, as opposed to working through its classical target cyclooxygenase (COXs) [XREF_BIBR]."

25874611

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"Here we demonstrate that the anti-inflammatory agents aspirin and sodium salicylate specifically inhibit IKK-beta activity in vitro and in vivo."

9817203

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"It has been shown that aspirin, as well as sodium salicylate, inhibits IKK-beta activity in vitro at millimolar concentration [XREF_BIBR] by binding to IKK-beta, thus, competing with ATP for the binding to the kinase, an event necessary to phosphorylate IkB [XREF_BIBR, XREF_BIBR]."

24281340

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"Whereas sulfasalazine was found to inhibit both IKKalpha and IKKbeta, aspirin and sodium salicylate were reported to specifically inhibit IKKbeta."

12110242

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reach

"Recently, sodium salicylate and aspirin have been shown to inhibit activation of the transcription factor NF-kappaB by preventing IKK-beta from degradation."

25120374

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reach

"Yuan et al. [XREF_BIBR] demonstrated that reduced signaling through the IKK-beta pathway inhibition by sodium salicylate in obese mice is accompanied by improved insulin sensitivity."

27034691

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reach

"Indeed, IKKbeta phosphorylates Bcl-xL (XREF_FIG, top panel), and this is specific since inhibition of IKKbeta by sodium salicylate prevents this reaction, and IKKalpha does not phosphorylate Bcl-xL."

19488402

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"We hypothesized that sodium salicylate would reduce IKKbeta, leading to reduced TNFalpha and improved insulin signaling in the BBZDR and Wor obese rat model of type 2 diabetes."

25874611

Sirolimus affects NLRP3

| 9

Sirolimus inhibits NLRP3. 9 / 9

| 9

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"Interestingly, Rapamycin inhibition of the NLRP3 inflammasome seemed to affect Caspase-1 activation as shown in Figure XREF_FIG D. Similar observations were made for MCC950, consistent with prior published observations."

29170665

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"Delayed oseltamivir and sirolimus combined treatment could suppress NLRP3 inflammasome mediated secretion of IL-1beta and IL-18, resulting in attenuation of H1N1 induced lung injury [XREF_BIBR]."

32235330

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reach

"p62 and SQSTM1 is essential for autophagy induction and NLRP3 inflammasome inhibition by rapamycin."

28489580

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reach

"Ko et al. found that autophagy inducer rapamycin restricted a feedback loop of NLRP3 inflammasome-p38 MAPK-NF-kappaB pathways in autophagy- and p62 dependent manners [XREF_BIBR]."

30876449

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reach

"In an experimental animal model of H1N1 influenza, rapamycin in combination with oseltamivir reduced viral replication and the NLRP3 inflammasome."

32422178

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reach

"Rapamycin inhibits NLRP3 inflammasome activation through autophagy induction."

28489580

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reach

"We first examined whether rapamycin inhibits NLRP3 inflammasome activation in macrophages."

28489580

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reach

"Results : We found that rapamycin reduced NLRP3 inflammasome activation in macrophages."

31736762

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reach

"Local intra-articular injection of rapamycin inhibits NLRP3 activity and prevents osteoarthritis in mouse DMM models."

31407595

Quercetin affects CASP1

| 1 8

Quercetin inhibits CASP1. 9 / 9

| 1 8

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"Western blot analysis indicates that LPS treatment induced degradation of caspase-1 precursor, which was inhibited by treatment CYT or quercetin."

21108840

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reach

"In conclusion, we suggest that CYT and quercetin decrease LPS induced inflammatory cytokine production by inhibiting NF-kappaB and caspase-1 activation."

21108840

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➶

reach

"CYT and quercetin also inhibited IL-32 production and caspase-1 activation."

21108840

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➶

reach

"To determine if CYT or quercetin inhibits caspase-1 activation induced by LPS, cells were exposed to LPS in the presence or absence of CYT (1 mg/ml) or quercetin (0.1 mM)."

21108840

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➶

reach

"In addition, quercetin reduced Caspase-1 activity observed in LPS plus nigericin (XREF_FIG)."

28148962

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medscan

"In addition, Chungsim-Yeunja-Tang and quercetin inhibited lipopolysaccharide-induced IL-32 expression and caspase-1 activation."

21108840

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reach

"The current study proved for the first time that quercetin treatment remarkably inhibited hypothalamic NLRP3 and caspase-1 in high fructose fed rats, being consistent with the reduction of hypothalamic TXNIP overexpression."

24491314

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reach

"Simultaneously, the treatment of quercetin at 50 and 100 mg/kg, as well as allopurinol at 5 mg/kg, remarkably reduced maturation of caspase-1 (quercetin and allopurinol : P <.001) and IL-1beta (quercetin : P <.05 and P <.01; allopurinol : P <.01) in the hypothalamus of high fructose fed rats."

24491314

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"Subsequently, Caspase-1 inhibition by quercetin and allopurinol prevented kidney IL-1beta and IL-18 release and over-production triggered by hyperuricemia and dyslipidemia in this model."

22701621

Pyruvic acid affects RELA

| 9

Pyruvic acid inhibits RELA. 9 / 9

| 9

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"It was also reported that ethyl pyruvate inhibited the nuclear association of RelA in human umbilical vein endothelial cells (Johansson et al., 2008; Mizutani et al., 2010)."

20969857

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reach

"Moreover, the levels of phospho-NF-KappaB p65 and phospho-IKappaBalpha were obviously increased in AVMC mice (P < 0.01); however, the presence of ethyl pyruvate reduced phospho-NF-KappaB p65 and phospho-IKappaBalpha (P < 0.05; Fig."

27026909

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➶

reach

"It is important to investigate how much the NF-kappaB pathway is involved in the different models of inflammation and whether or not ethyl pyruvate inhibits the functions of NF-kappaB in each model.Previously, using biochemical methods, we found that ethyl pyruvate inhibited the nuclear association of RelA in A549 cells (Mizutani et al., 2010)."

20969857

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➶

reach

"Next, we examined whether ethyl pyruvate inhibited the binding of RelA (1-220) or p50 to the [32 P]-labeled NF-kappaB probe."

20969857

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➶

reach

"In the present study, we confirmed that ethyl pyruvate inhibited the nuclear association of RelA with immunostaining methods."

20969857

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➶

reach

"Studies in vitro suggested that ethyl pyruvate inhibited p65 by covalently modifying cysteine residues necessary for its DNA binding [XREF_BIBR]."

19555300

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➶

reach

"Furthermore, immunostaining of A549 cells revealed that ethyl pyruvate inhibited the nuclear association of RelA after TNFalpha treatment."

20969857

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➶

reach

"Ethyl pyruvate was suggested to inhibit NF-kappaB and DNA-binding activity by alkylating RelA at cysteine 38 (Han et al., 2005)."

20969857

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➶

reach

"However, ethyl pyruvate directly inhibited binding of the p65 subunit of NF-kappaB to DNA while having no effect on the p50 subunit."

16356237

Poly I:C affects IFNB1

| 9

Poly I:C inhibits IFNB1. 9 / 9

| 9

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"When Trim65 -/- BMDMs were stimulated with cytosolic HMW poly I : C, LMW poly I : C, 5 '-triphosphate RNA (3pRNA, agonist for RIG-I), extracellular LPS (agonist for TLR4), or poly I : C (agonist for TLR3), only HMW poly I : C induced IFN-beta production was blocked as expected (XREF_FIG), confirming that TRIM65 is specifically involved in MDA5 activation."

28031478

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➶

reach

"The reduction of voluntary physical activity after poly I : C injection is independent of the effect of poly I : C induced interferon-beta in mice."

18191426

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➶

reach

"Erythromycin suppresses poly I : C induced IFN-beta production by reducing TLR3 expression by monocyte derived dendritic cells [66]."

27468646

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➶

reach

"In addition, U0126 inhibited poly I : C induced IFN-beta, IL-6, and iNOS expression as well as induction of NO downstream of these cytokines."

23892079

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➶

reach

"The Actinomycin D concentration used (1mug/mL) did not affect BMDM viability, but was sufficient to block de novo expression of IFNbeta in BMDM treated with poly I : C (XREF_SUPPLEMENTARY)."

23935197

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➶

reach

"XREF_BIBR Consistent with its inhibitory effect on poly I : C induced IFN-beta gene expression, PAR 2 AP also inhibited poly I : C induced TLR3 mRNA expression (XREF_FIG)."

19865078

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➶

reach

"A deficiency of PAR-1 was associated with significantly lower levels of poly I : C dependent induction of IFNbeta, IFNgamma, CXCL10, IRF7 and viperin but not CCL5 mRNA expression (XREF_FIG)."

27820939

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➶

reach

"As shown in XREF_FIG, only the p38 inhibitor (SB202190), but not ERK or JNK inhibitors (U0126 or SP600125), significantly inhibited poly I : C induced IFN-beta promoter activation."

23056170

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➶

reach

"Targeting RIG-I and MDA5 helicases by poly I : C transfection with a lipid carrier as reported by [XREF_BIBR], did not result in MHV mediated inhibition of poly I : C induced IFN-beta secretion."

22754655

Nitric oxide affects NFKB1

| 9

Nitric oxide inhibits NFKB1. 9 / 9

| 9

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➶

reach

"For example NO is known to inhibit NFkB activation."

18940177

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➶

reach

"In our hands, NO inhibits HIV 1 replication in infected peripheral blood mononuclear cells, suggesting that NO may inhibit NF-KB activity in these cells."

8852613

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➶

reach

"Inhibition of NO synthase by l -NAME increased p50 activation in the absence of shear, and prevented the downregulation of p50 activity at 90 min."

16099468

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➶

reach

"Treatment with l-NAME increased binding of the NFkappaB subunit p50 to consensus oligonucleotide coated microtiter plates, while having only minimal effect on binding of p65, strongly suggesting that nitric oxide mainly inhibits p50 activation."

16099468

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➶

reach

"Moreover, enhanced NO production can be responsible for decreased TNF production, as NO was described to inhibit NFkB transcription factor involved in synthesis of TNF-alpha and several cytokines (Mantovani et al., 1997; Forstermann et al., 1998)."

10802291

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➶

reach

"The reduction in NO production determined by ebselen in RIN cells was associated with a decrease in iNOS mRNA expression but not with an inhibition of IL-1- induced NF-KB activation."

8986132

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➶

reach

"Recently it has been reported that NO inhibits the activation of the transcription factor NF-KB (21)."

8809229

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➶

reach

"As a limitation, other potential underlying mechanisms such as decreased mRNA 43, increased degradation of sGC, or high NO induced NFkB activation that downregulate sGC XREF_BIBR, XREF_BIBR have not been addressed by our study 63 and can not be excluded."

32561822

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➶

reach

"For example, NO 2 -FAs inhibit NFkB activity by nitroalkylating the p65 subunit, thereby suppressing NFkB mediated pro inflammatory cytokine and adhesion protein expression [XREF_BIBR]."

19857569

Naloxone affects ITCH

| 9

Naloxone inhibits ITCH. 9 / 9

| 9

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"An intradermal injection of serotonin (100 nmol and site) to the rostral back induced scratching, an itch related behavior, which was inhibited by subcutaneous (1 mg/kg) and intracisternal (10 nmol and site) injections of naloxone."

18981588

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➶

reach

"Intracisternal, but not intrathecal, injection of naloxone inhibits cutaneous itch related response in mice."

18981588

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➶

reach

"As a third-line option, (3) opioid antagonists (naloxone, nalmefene, naltrexone) have been found to reduce itch severity in patients with PBC [298, 302–304]."

19603170

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➶

reach

"Previous studies have demonstrated that scratching is mediated by an opioid mechanism, since systemically administered mu, delta and kappa opioid agonists exhibit potent antipruritic activity in the compound 48/80 induced itch model that could be antagonized by the opioid antagonists naloxone or norBNI [8,11]."

12383884

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➶

reach

"Naloxone and naltrexone also suppress the itch sensation in patients with chronic cholestasis, chronic renal failure and atopic dermatitis (Bergasa et al., 1992; Peer et al., 1996; Metze et al., 1999)."

11821035

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➶

reach

"As a thirdline option, (3) opioid antagonists (naloxone, nalmefene, naltrexone) have been found to reduce itch severity in patients with PBC [298, [302] [303] [304] ."

19603170

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➶

reach

"Interestingly, naloxone, an antidote for morphine, suppresses itch in patients with chronic renal failure and AD 9."

22578170

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➶

reach

"As a third-line option, (3) opioid antagonists (naloxone, nalmefene, naltrexone) have been found to reduce itch severity in patients with PBC [XREF_BIBR, XREF_BIBR - XREF_BIBR]."

19603170

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➶

reach

"Moreover, the 5-HT-evoked biting was suppressed by naloxone, suggesting that it reflects itch."

23891755

Metformin affects NLRP3

| 9

Metformin inhibits NLRP3. 9 / 9

| 9

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➶

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"Metformin Inhibits the NLRP3 Inflammasome via AMPK and mTOR dependent Effects in Diabetic Cardiomyopathy."

31182921

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➶

reach

"Metformin reduced NLRP3 inflammasome activity in Ox-LDL stimulated macrophages through adenosine monophosphate activated protein kinase and protein phosphatase 2A."

30851273

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➶

reach

"The aim of this study was to investigate whether metformin can inhibit the NLRP3 inflammasome by activating the AMPK and mTOR pathway in DCM."

31182921

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➶

reach

"Furthermore, after stimulation with the mTOR inhibitor rapamycin, additional metformin treatment could still downregulate Nek7 and NLRP3."

30779140

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➶

reach

"Metformin inhibited NLRP3 inflammasomes activation and suppressed diabetes accelerated atherosclerosis in apoE -/- mice, which at least partially through activation of AMPK and regulation of thioredoxin-1 and thioredoxin-interacting protein."

31518877

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➶

reach

"Metformin and resveratrol protected mitochondrial integrity by inhibiting Drp1 activity and prevented NLRP3 inflammasome activation by suppressing ER stress, and thereby protected adipose function from high glucose insult."

27276511

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➶

reach

"71 Metformin and empagliflozin, two well-known antidiabetic drugs, inhibited NLRP3 inflammasome and decelerated the development of diabetic cardiomyopathy but via different mechanisms."

| PMC

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➶

reach

"Furthermore, after stimulation with the mTOR inhibitor rapamycin, additional metformin treatment could still downregulate Nek7 and NLRP3."

30945296

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➶

reach

"In our study, we observed that Metformin significantly suppressed accumulation of the NLRP3 inflammasome and activation of Caspase-1."

32330868

Dihydroartemisinin affects NLRP3

| 1 8

Dihydroartemisinin inhibits NLRP3. 9 / 9

| 1 8

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➶

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"Interestingly, the ability of EPA and DHA to inhibit NLRP3 inflammasome activation was not dependent upon their enzymatic metabolism to lipid mediators (e.g., resolvins), but was, in part, dependent upon a GPR120 mediated interaction between betaarr2 and NLRP3 [XREF_BIBR]."

29186929

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➶

reach

"Since long-chain FAs can activate GPR120 and GPR40 [96] and GPR120 is also involved in the anti-inflammatory effects of omega-3 FAs [93], they tested the role of both receptors on DHA induced NLRP3 inhibition."

25175736

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➶

reach

"XREF_BIBR, XREF_BIBR Remarkably, both the NLRP3 inflammasome and mTORC1 are activated by palmitic acid and inhibited by DHA, respectively."

26203267

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➶

reach

"To date, only one study has shown that gavage of DHA in high-fat diet fed mice attenuated NLRP3 inflammasome activation and prevented mice from high-fat diet induced insulin resistance at a whole-body level."

28729463

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➶

reach

"Recently DHA was reported to inhibit NALP3 inflammasome activation in LPS primed bone-marrow-derived macrophages [49]."

27142735

---

➶

reach

"However, DHA could inhibit the NLRP3 inflammasome independently of these metabolites."

25175736

---

➶

reach

"For example, a recent study has shown that EPA and DHA inhibit the NLRP3 inflammasome in macrophages, independently from their enzymatic products."

29706960

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➶

reach

"showed that DHA suppressed NLRP3 inflammasome by inhibiting NF-kappab activation and enhancing autophagy in macrophages."

28729463

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➶

sparser

"Since long-chain FAs can activate GPR120 and GPR40 [96] and GPR120 is also involved in the anti-inflammatory effects of ω-3 FAs [93] , they tested the role of both receptors on DHA-induced NLRP3 inhibition."

25175736

Curcumin affects CHUK

2 | 7

Curcumin inhibits CHUK. 9 / 9

2 | 7

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➶

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"Curcumin (10 muM) markedly inhibited IKK1 and IKK2 activity induced by LPS, whereas tetrahydrocurcumin (4H), hexahydrocurcumin (6H), and octahydrocurcumin (8H) showed a less inhibitory effect at the same concentration."

11077049

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➶

reach

"Furthermore, we showed that curcumin could inhibit the IkappaB kinase 1 (IKK1) and IkappaB kinase 2 (IKK2) activities induced by LPS, but tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin were less active."

11077049

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➶

reach

"Curcumin, the yellow pigment derived from Curcuma longa, inhibited IKKalpha, IKKbeta and NIK, indicating its strong potential to block NF-kappaB-mediated cytokine release and the innate immune response."

15927892

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➶

reach

"Our data indicated that there is a reduced expression of IKKalpha and IKKbeta in tumor of mice treated with curcumin with respect to controls, indicating that curcumin inhibits NF-kappaB activation through suppression of IKK (XREF_FIG)."

24324975

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➶

reach

"Taken together, these results indicate that curcumin blocks IKK-alpha activation through inhibition of an upstream protein kinase B (Akt)."

21669872

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➶

ctd

No evidence text available

16219905

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➶

reach

"Our results demonstrated that oral administration of 0.05% curcumin significantly inhibited the up-regulation of IKKalpha, without affecting the expression level of IKKbeta, after I/R injury (XREF_FIG)."

21858029

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➶

reach

"Our data also showed that curcumin inhibited the expression of several important proteins regulated by NF-kappaB; in particular, we demonstrated that there is a reduced expression of IKKalpha and IKKbeta in tumor of mice treated with curcumin with respect to controls, indicating that curcumin inhibits NF-kappaB activation through suppression of IKK in MIA PaCa-2 cells."

24324975

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➶

ctd

No evidence text available

16023083

Chloroquine affects ITCH

| 9

Chloroquine inhibits ITCH. 9 / 9

| 9

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➶

reach

"Inhibition of M/K v 7 Currents Contributes to Chloroquine Induced Itch in Mice."

32694980

---

➶

reach

"Higher doses of chloroquine (200 mug or 400 mug) together with QX-314 blocked later chloroquine itch behavior, but not scratching evoked by histamine."

23685721

---

➶

reach

"Loss of Bhlhb5 interneurons abolished the inhibition effect of menthol on chloroquine induced itch [XREF_BIBR] confirming that " counter-stimuli " sensed by Trp channels work through Bhlhb5 inhibitory interneurons to achieve itch inhibition."

26385480

---

➶

reach

"We found that systemic administration of NAC or PBN significantly alleviated compound 48/80- and chloroquine induced acute itch in a dose dependent manner, attenuated dry skin induced chronic itch, and suppressed oxidative stress in the affected skin."

27783328

---

➶

reach

"Finally, a comparison of the strain means obtained here with previously collected data using nociceptive assays revealed a suggestive negative genetic correlation between chloroquine induced itch and thermal pain, such that strains sensitive to pain are resistant to itch and vice versa."

16697529

---

➶

reach

"Neuronal responses to chloroquine were prevented by inhibiting Gbetagamma subunit activity, suggesting that the G alphaq pathway is not necessary for chloroquine induced itch [XREF_BIBR]."

25558916

---

➶

reach

"In GRPR knockout mice, scratching from histamine, SLIGRL and chloroquine induced itch was reduced [XREF_BIBR]."

23497684

---

➶

reach

"Based on our in vitro results (XREF_FIG) we hypothesized that intradermal administration of chloroquine with QX-314 could block chloroquine itch by permitting selective uptake of QX-314 through chloroquine mediated activation of TRPA1 12."

23685721

---

➶

reach

"Compared to wild-type (WT) mice, TNFR1-knockout (TNFR1-KO) and TNFR1/R2 double-KO (DKO), but not TNFR2-KO mice, exhibited reduced acute itch induced by compound 48/80 and chloroquine (CQ)."

28365861

Arachidonic acid affects NLRP3

| 9

Arachidonic acid inhibits NLRP3. 9 / 9

| 9

---

➶

reach

"Inhibition of PPARgamma abolishes the protective effects of AA against I/R induced inflammatory injury and NLRP3 inflammasome activation."

29156799

---

➶

reach

"These findings were also confirmed by in vitro experiments in which AA pretreatment suppressed NLRP3 activation in LPS/H 2 O 2 -challenged KCs or RAW264.7 cells."

29156799

---

➶

reach

"Administration of AA significantly attenuated hepatic histopathological damage, global inflammatory level, apoptotic signaling level, as well as NLRP3 inflammasome activation."

29156799

---

➶

reach

"PPARgamma/ROS/MAPK and PPARgamma/ROS/NF-kappaB involve in AA mediated suppression of NLRP3 inflammasome."

29156799

---

➶

reach

"Therefore, AA attenuated NLRP3 signaling both at expression level and assembly level."

29156799

---

➶

reach

"Administration of AA significantly suppressed NLRP3 activation and global inflammatory levels in the ischemic liver."

29156799

---

➶

reach

"AA decreases NLRP3 inflammasome activation in ischemic liver."

29156799

---

➶

reach

"Furthermore, GW9662 reversed AA mediated suppression of NLRP3 signaling, as evidenced by increase in mRNA levels of NLRP3 and IL-1beta, protein levels of NLRP3 and pro-IL-1beta, formation of NLRP3, ASC, pro, and caspase-1 complex as well as production of cleaved capase-1 p10 and mature IL-1beta."

29156799

---

➶

reach

"Emerging evidence demonstrates that AA inhibits NLRP3 inflammasome assembling and caspase-1 inhibition in macrophage [XREF_BIBR]."

29156799

NAC affects CASP1

| 9

NAC inhibits CASP1. 9 / 9

| 9

---

➶

reach

"We therefore examined Ulk1 -/- BMDCs and found that they also have increased caspase-1 activation following IAV infection and this increased caspase-1 activation was suppressed by NAC treatment (XREF_FIG)."

23525089

---

➶

reach

"DPI and NAC strongly inhibited caspase-1 processing, whereas BAY-117082 had little impact on cells stimulated with S100A8, S100A9, or LPS in the presence of ATP (XREF_FIG)."

23977231

---

➶

reach

"In contrast, NAC inhibited caspase-1 activation in response to TLR signaling (XREF_FIG)."

24043892

---

➶

reach

"And ROS scavenger NAC attenuated the activation of caspase-1 induced by MST1 and the effect of MST1 in PDAC cell death, proliferation, migration and invasion."

30796177

---

➶

reach

"The antioxidant NAC inhibited caspase-1 activation and IL-1beta secretion (XREF_FIG)."

25367573

---

➶

reach

"IL-1 beta release and caspase-1 activity induced by DSS were significantly inhibited by a MAPK kinase 1/2 inhibitor, a p38 MAPK inhibitor, and NAC, however, not by JNK1/2 or a protein kinase C inhibitor."

17628610

---

➶

reach

"Finally, Rip2 -/- BMDM treated with the ROS scavenger N-acetyl-L-cysteine (NAC) had reduced caspase-1 activation and IL-18 production compared to WT cells (XREF_FIG)."

25254654

---

➶

reach

"Addition of extracellular potassium or the reactive oxygen scavenger NAC, both of which can prevent activation of the NLRP3 inflammasome, did not prevent activation of caspase-1 in response to infection with either the T3SS or the WT Yersinia strains (XREF_FIG and data not shown)."

20478539

---

➶

reach

"Additionally, in LPS stimulated PMs, NAC treatment abolished caspase-1 activation (XREF_FIG) and IL-1beta secretion (XREF_FIG) induced by CGI-58 knockout."

24703845

N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide affects RIPK1

3 | 2 4

N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide inhibits RIPK1. 9 / 9

3 | 2 4

---

➶

reach

"Although Tozasertib inhibits RIPK1 dependent apoptosis in MEF cells, its inhibition on RIPK1 dependent necroptosis in the same cells is remarkably less effective."

29434255

---

➶

tas

No evidence text available

18183025

---

➶

sparser

"Overall, these data indicate that the inhibition of Aurora kinases and RIPK1 by Tozasertib and its analogues is correlated to the proliferation and cytokinesis defects and necroptosis protection, respectively."

29434255

---

➶

reach

"Finally, Tozasertib inhibited recombinant human RIPK1, human Aurora A and human Aurora B kinase activity, but not RIPK3."

29434255

---

➶

tas

No evidence text available

29437386

---

➶

reach

"Overall, these data indicate that the inhibition of Aurora kinases and RIPK1 by Tozasertib and its analogues is correlated to the proliferation and cytokinesis defects and necroptosis protection, respectively."

29434255

---

➶

reach

"Finally, Tozasertib also blocks RIPK1 dependent necroptosis in the human HT29 cell line with an IC50 of 0.26 microM."

29434255

---

➶

tas

No evidence text available

22037378

---

➶

sparser

"Finally, Tozasertib inhibited recombinant human RIPK1, human Aurora A and human Aurora B kinase activity, but not RIPK3."

29434255

ATP affects JAK1

| 1 8

ATP inhibits JAK1. 8 / 8

| 8

---

➶

reach

"AZD1480, an ATP competitive inhibitor of JAK1 and JAK2, has beneficial effects in cancer models by suppressing downstream activation of STATs, particularly STAT3."

24323580

---

➶

reach

"To test whether inhibition of the JAK and STAT3 pathway would affect the growth of pediatric solid tumors, we evaluated the anti-tumor activity of AZD1480, an ATP competitive inhibitor of JAK1 and JAK2, which has been shown to decrease the growth of adult tumors in several pre-clinical models [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."

23531921

---

➶

reach

"Next, we attempted to inhibit downstream of the IFN pathway by using a pan-JAK inhibitor, tetracyclic pyridone 6 (P6), a potent, cell-permeable, and ATP competitive inhibitor of JAK1, JAK2, JAK3, and Tyk2."

29731430

---

➶

reach

"As an ATP competitive inhibitor of JAK1 and JAK2, AZD1480 was recently shown to inhibit activation of STAT3 and depress the growth of multiple adult tumors [XREF_BIBR, XREF_BIBR]."

23531921

---

➶

reach

"AZD1480, an ATP competitive inhibitor of JAK1 and JAK2, was recently shown to inhibit the growth of solid tumors including breast, ovarian and prostate."

22027691

---

➶

reach

"Many compounds with JAK inhibitory activity have been generated, with several currently being assessed in clinical trials of human patients diagnosed with MPN and acute myeloid leukemia (AML).8 AZD14801 is a pyrazolopyrimidine ATP competitive inhibitor of JAK1 and JAK2, with some activity against JAK3, TYK2, and Aurora-A kinase at high maximal inhibitory concentration (IC) values."

28960447

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➶

reach

"We first reported that AZD1480, an ATP competitive inhibitor of JAK1 and JAK2 inactivated STAT3 mediated signaling and inhibited tumor growth in pediatric solid tumors such as NB, Ewing sarcoma, and rhabdomyosarcoma in vitro and in vivo."

27797972

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➶

reach

"168 We have recently demonstrated that AZD1480, an ATP competitive inhibitor of JAK1 and JAK2, has striking protective effects in multiple models of EAE XREF_BIBR, XREF_BIBR (XREF_FIG)."

27279046

ATP inhibits JAK1-V658F. 1 / 1

| 1

---

➶

medscan

"Disrupting ATP binding in JH2 also inhibits the hyperactivity of other pathogenic JAK2 mutants, as well as of JAK1 V658F, and prevents induction of erythrocytosis in a JAK2 V617F myeloproliferative neoplasm mouse model. 999997={Protein=3717 Mutation=46999998} 46999998="V617F" 46999999="V658F"}"

25825724

Withaferin A affects IKBKG

| 5 3

Withaferin A inhibits IKBKG. 8 / 8

| 5 3

---

➶

medscan

"In the canonical pathway induced by TNF, Withaferin A did not disrupt RIP1 polyubiquitination or NEMO-IKKβ interaction and was a poor direct IKKβ inhibitor, but prevented the formation of TNF-induced NEMO foci which colocalized with TNF ligand."

25304104

---

➶

reach

"Withaferin A blocks the formation of TNF- and IL-1-induced NEMO structures."

25304104

---

➶

medscan

"Although Withaferin A inhibits NEMO foci formation and downstream Nuclear Factor kappa B inhibition, it is important to note that Withaferin A is not specific to NEMO."

25304104

---

➶

reach

"Instead, we found that WA disrupts ubiquitin dependent NEMO reorganization induced by TNF."

25304104

---

➶

medscan

"Our study reveals that Withaferin A is a novel type of IKK inhibitor which acts by disrupting NEMO reorganization into ubiquitin-based signaling structures in vivo."

25304104

---

➶

medscan

"Thus, our findings are consistent with the notion that Withaferin A disrupts NEMO's ability to reorganize into ubiquitin-based signaling structures in vivo."

25304104

---

➶

reach

"WA disruption of NEMO reorganization was associated with the lack of IKKbeta activation despite efficient activation of the upstream kinase, TAK1."

25304104

---

➶

medscan

"Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling."

25304104

Resveratrol affects MAPK8

2 | 5 1

Resveratrol inhibits MAPK8. 8 / 8

2 | 5 1

---

➶

medscan

"Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction."

14661062

---

➶

medscan

"Resveratrol inhibited phorbol myristate acetate-mediated activation of c-Jun N-terminal kinase (JNK) and protein kinase C -delta activation."

14661062

---

➶

medscan

"Therefore, we conclude that the MMP-9 inhibition activity of resveratrol and its inhibition of JNK and PKC-delta may have a therapeutic potential, given that a novel means of controlling growth and invasiveness of tumors."

14661062

---

➶

medscan

"This study verifies that resveratrol inhibits u-plasminogen activator through phosphorylation of the JNK 1/2 pathway to induce an anti-metastasis effect."

23437203

---

➶

medscan

"Western blot analysis also showed that resveratrol inhibits phosphorylation of JNK1/2."

23437203

---

➶

reach

"In cervical carcinoma cells, resveratrol inhibited the activation of p38, JNK1, and ERK2 [XREF_BIBR]."

29194365

---

➶

ctd

No evidence text available

11408617

---

➶

ctd

No evidence text available

10356984

Quercetagetin affects MAPK8

| 1 1 6

Quercetagetin inhibits MAPK8. 8 / 8

| 1 1 6

---

➶

reach

"Only quercetagetin strongly suppressed JNK1 activity."

23142567

---

➶

sparser

"To investigate the molecular basis of the inhibition of JNK1 by quercetagetin ( xref ), we determined the crystal structure of the JNK1–pepJIP1–quercetagetin ternary complex, where pepJIP1 is a docking site peptide fragment of the scaffold protein JIP1."

23142567

---

➶

reach

"In vitro JNK1 kinase assays revealed that quercetagetin inhibited JNK1 activity more potently than did SP600125 (a pharmacological JNK1 inhibitor)."

23142567

---

➶

reach

"The recent discovery of c-Jun NH2-terminal kinase JNK1 suppression by natural quercetagetin (1) is a promising lead for the development of novel anticancer agents."

26541354

---

➶

reach

"Quercetagetin inhibited JNK1 activity more strongly than did quercetin, myricetin, kaempferol, or SP600125."

23142567

---

➶

reach

"Overall, our crystallographic findings, the accompanying biochemical data, and the cell based and animal model data show that quercetagetin is a strong inhibitor of JNK1 and PI3-K and might have practical implications for the prevention or therapy of cancer and other chronic diseases."

23142567

---

➶

eidos

"Quercetagetin attenuated JNK1 activity with an IC50 value of 4.6 muM , which is even more potent than SP600125 ( IC50 = 5.2 muM ) , in the immobilized metal ion affinity-based fluorescence polarization assay ."

32637042

---

➶

reach

"To investigate the molecular basis of the inhibition of JNK1 by quercetagetin (XREF_FIG), we determined the crystal structure of the JNK1-pepJIP1-quercetagetin ternary complex, where pepJIP1 is a docking site peptide fragment of the scaffold protein JIP1."

23142567

Pyruvic acid affects NLRP3

| 8

Pyruvic acid inhibits NLRP3. 8 / 8

| 8

---

➶

reach

"Ethyl pyruvate specifically inhibits the NLRP3 inflammasome activation."

30134814

---

➶

reach

"We previously found that ethyl pyruvate (EP), a metabolite derivative, is able to effectively inhibit the NLRP3 inflammasome activation."

32517686

---

➶

reach

"Though whether cytosolic oxidized mitochondrial DNA is a bona fide NLRP3 ligand requires further investigation, our findings suggest that ethyl pyruvate inhibits the NLRP3 inflammasome activation, at least in part, through preventing mitochondrial damage."

30134814

---

➶

reach

"Mechanistically, ethyl pyruvate inhibits the NLRP3 inflammasome activation, at least in part, by reducing mitochondrial damage."

30134814

---

➶

reach

"To determine whether ethyl pyruvate (EP) inhibits the NLRP3 inflammasome activation, LPS primed mouse peritoneal macrophages were stimulated with ATP in the presence or the absence of different concentrations of EP."

30134814

---

➶

reach

"Given that infection with S. typhimurium is an activator of the NLRP3 inflammasome 37 and that S. typhimurium mediated NLRP3 activation can be abrogated by pyruvate supplementation 34, this metabolic signature may constitute an important signal in inflammasome activation."

27508077

---

➶

reach

"Pyruvate supplementation had no effect on inflammasome signaling induced by the NLRP3 activators ATP and nigericin (XREF_FIG), indicating that pyruvate does not impair NLRP3 inflammasome signaling by a nonspecific mechanism."

27011353

---

➶

reach

"These observations suggest that ethyl pyruvate inhibits the NLRP3 inflammasome activation through affecting the downstream signal of potassium efflux."

30134814

Prostaglandin E2-UM affects NLRP3

| 1 7

Prostaglandin E2-UM inhibits NLRP3. 8 / 8

| 1 7

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➶

reach

"Having found that exogenous PGE 2 inhibits NLRP3 inflammasome activation in human primary MDM, we wondered whether endogenous PGE 2 production might serve as a regulatory autocrine or paracrine mechanism against excessive NLRP3 activation."

25917098

---

➶

reach

"Thus, PGE 2 specifically inhibited the activity of NLRP3 inflammasome."

25917098

---

➶

reach

"Here we found that PGE 2 decreased NLRP3 inflammasome activation, triggered by aluminum crystals, ATP or nigericin."

25917098

---

➶

reach

"Here we have found that PGE 2 inhibited NLRP3 inflammasome activation in human primary MDM."

25917098

---

➶

reach

"PGE 2 inhibits NLRP3 inflammasome through EP4 receptor."

25917098

---

➶

reach

"Here, we showed that NLRP3 inflammasome activation is inhibited by PGE 2 in human primary monocyte derived macrophages."

25917098

---

➶

reach

"Using multiple pharmacological and molecular approaches, we have determined that PGE 2 acted specifically through EP4 to decrease NLRP3 inflammasome activation in human primary MDM."

25917098

---

➶

sparser

"This suggests that the proposed PGE 2 -mediated inhibition of NLRP3 by increase in cAMP might be an additional mechanism of ω-3 derived effects."

25917098

Phenethyl caffeate affects RELA

1 | 2 5

Phenethyl caffeate inhibits RELA. 8 / 8

1 | 2 5

---

➶

reach

"Moreover, CAPE inhibited the nuclear transport of NF-kappaB p65 subunit, decreased the level of tumor necrosis factor-alpha, nitric oxide and inducible nitric oxide synthase."

25704035

---

➶

reach

"IF staining revealed that CAPE inhibited p65 to enter the nucleus of 109-T15 and 9706-T15 cells compared to the cells with DMSO treatment."

29650964

---

➶

sparser

"IF staining revealed that CAPE inhibited p65 to enter the nucleus of 109- T15 and 9706- T15 cells compared to the cells with DMSO treatment (Fig.  xref , lower)."

29650964

---

➶

sparser

"IF staining revealed that CAPE inhibited p65 to enter the nucleus of 109- T15 and 9706- T15 cells compared to the cells with DMSO treatment (Fig.  xref , lower)."

29650964

---

➶

reach

"Our animal study also revealed that CAPE treatment reduced protein abundance of NF-kappaB p65 in PC-3 tumors."

27191743

---

➶

reach

"However, CAPE and CAPE-pNO 2 significantly increased 1.4- and 1.5-fold in cytoplasm p65 expression and decreased 0.8- and 0.7-fold in nuclear p65; as well as p-IkappaBalpha was 0.7- and 0.7-fold and TGF-beta1was 0.6- and 0.3-fold at 20 muMu, compared with the HG induced GMCs, which had similar effects to those of caused by 100 muM PDTC treatment."

29383098

---

➶

ctd

No evidence text available

16052512

---

➶

reach

"CAPE, an inhibitor of NF-kappaB, inhibited NF-kappaB p65 activation and inhibited the upregulation of TLR4, angiotensinogen and AT 1a receptors induced by LPS."

30344664

Phenethyl caffeate affects CASP1

| 8

Phenethyl caffeate inhibits CASP1. 8 / 8

| 8

---

➶

reach

"In mouse gouty arthritis models, oral administration of CAPE suppressed MSU crystals induced caspase-1 activation and IL-1beta production in the air pouch exudates and the foot tissues, correlating with attenuation of inflammatory symptoms."

27934918

---

➶

reach

"CAPE did not directly bind to NLRP3 PYD, nor inhibited caspase-1 enzyme activity."

27934918

---

➶

reach

"An in vitro caspase-1 enzyme activity assay confirmed that CAPE did not directly inhibit caspase-1 activity (XREF_FIG)."

27934918

---

➶

reach

"Oral administration of CAPE prevented the cleavage of pro-caspase-1 to caspase-1 (p10) and of pro-IL-1beta to IL-1beta in foot tissue injected with MSU crystals (XREF_FIG)."

27934918

---

➶

reach

"CAPE inhibited MSU crystal induced cleavage of pro-caspase-1 and pro-IL-1beta, to caspase-1 (p10) and IL-1beta, respectively, in the cellular supernatants (XREF_FIG)."

27934918

---

➶

reach

"In primary mouse macrophages, caffeic acid phenethyl ester (CAPE) blocked caspase-1 activation and IL-1beta production induced by MSU crystals, showing that CAPE suppresses NLRP3 inflammasome activation."

27934918

---

➶

reach

"In primary mouse macrophages, caffeic acid phenethyl ester (CAPE) blocked caspase-1 activation and IL-1beta production induced by MSU crystals, showing that CAPE suppresses NLRP3 inflammasome activation."

27934918

---

➶

reach

"CAPE suppressed ATP induced cleavage of pro-caspase-1 and pro-IL-1beta to caspase-1 (p10) and IL-1beta in BMDMs (XREF_SUPPLEMENTARY) and reduced ATP induced secretion of IL-1beta and IL-18 (XREF_SUPPLEMENTARY)."

27934918

Parthenolide affects IKBKB

| 3 5

Parthenolide inhibits IKBKB. 8 / 8

| 3 5

---

➶

reach

"A well-studied constituent, parthenolide, specifically binds to and inhibits IKK-beta, which is involved in cytokine-mediated signaling."

| PMC

---

➶

reach

"We show that parthenolide effectively inhibits the IKK activity of a constitutively active IKKbeta (SS/EE mutant), thus demonstrating that parthenolide acts at the level of IKKbeta."

11514225

---

➶

reach

"The IKK inhibitors parthenolide and aspirin blocked the activities of infection induced IKKalpha and IKKbeta, leading to attenuation of nuclear translocation of NF-kappaB."

15618150

---

➶

sparser

"However, the fact that parthenolide can inhibit a constitutively active IKKβ (SS/EE) mutant does not support this hypothesis as the sole mechanism."

11514225

---

➶

reach

"The molecular mechanism of IKKbeta inhibition by parthenolide remains unknown."

11514225

---

➶

sparser

"The molecular mechanism of IKKβ inhibition by parthenolide remains unknown."

11514225

---

➶

sparser

"Since IKKβ, IKKα, and the upstream kinase MEKK1 have been previously reported not to be the target of parthenolide [19] , and we show here that parthenolide inhibits IκB phosphorylation in response to TNFα, it was important to determine if parthenolide directly inhibits IKKβ or the activity of an upstream IKK kinase."

11514225

---

➶

reach

"To exclude the possibility that parthenolide prevents IKKbeta activation via inhibition of an upstream kinase, constitutively active IKKbeta was tested for sensitivity to parthenolide."

11514225

Naltrexone affects ITCH

| 8

Naltrexone inhibits ITCH. 8 / 8

| 8

---

➶

reach

"The spontaneous scratching of NC mice with dermatitis was inhibited by distraction and the opioid antagonist naltrexone, suggesting that the scratching is itch associated response."

11154860

---

➶

reach

"Naloxone and naltrexone also suppress the itch sensation in patients with chronic cholestasis, chronic renal failure and atopic dermatitis (Bergasa et al., 1992; Peer et al., 1996; Metze et al., 1999)."

11821035

---

➶

reach

"A placebo controlled study in 18 patients with chronic pruritic associated with a variety of disorders showed that naltrexone, applied topically, significantly decreased itch."

26739556

---

➶

reach

"As a third-line option, (3) opioid antagonists (naloxone, nalmefene, naltrexone) have been found to reduce itch severity in patients with PBC [298, 302–304]."

19603170

---

➶

reach

"As a thirdline option, (3) opioid antagonists (naloxone, nalmefene, naltrexone) have been found to reduce itch severity in patients with PBC [298, [302] [303] [304] ."

19603170

---

➶

reach

"Persistent itch in dialysis patients was relieved by naltrexone [317], and pruritus in post-Caesarean section patients with epidural morphine was attenuated by naloxone or nalbuphine [209], suggesting opiate involvement.Unilateral peripheral vestibular deafferentation in the guinea pig produced spontaneous nystagmus that was reduced by naloxone [108], so that there was opiate mediation of the occular motor effects."

9437729

---

➶

reach

"Using meta-analyses of randomized double-blind placebo controlled studies in which itch intensity was measured and longitudinally tracked, they reported that nalfurafine and gabapentin were effective for reducing uraemic itch, naltrexone reduced chronic itch from cholestasis and atopic dermatitis, and ursodeoxycholic acid reduced itch from intrahepatic cholestasis of pregnancy."

26415674

---

➶

reach

"As a third-line option, (3) opioid antagonists (naloxone, nalmefene, naltrexone) have been found to reduce itch severity in patients with PBC [XREF_BIBR, XREF_BIBR - XREF_BIBR]."

19603170

Luteolin affects NFKBIA

| 1 2 5

Luteolin inhibits NFKBIA. 8 / 8

| 1 2 5

---

➶

medscan

"However, it is presently unclear how luteolin ablates the IκBα/NF-κB signaling pathway."

25577468

---

➶

reach

"[XREF_BIBR] Our result showed that luteolin inhibited the downregulation of IkappaBalpha in a dose dependent manner when compared to control adipocytes."

26246742

---

➶

reach

"Digitoflavone Inhibits IkappaBalpha Kinase and Enhances Apoptosis Induced by TNFalpha through Downregulation of Expression of Nuclear Factor kappaB Regulated Gene Products in Human Pancreatic Cancer Cells."

24146961

---

➶

eidos

"In addition , luteolin inhibited endothelial NF-kappaB transcriptional activity , IkappaB-alpha degradation and IkappaB-beta expression , and thus reduced NF-kappaB p65 nuclear translocation ."

32326376

---

➶

medscan

"To our knowledge, we are the first to show that luteolin at physiological concentrations potently suppresses IκBα degradation and NF-κB nuclear translocation in ECs."

25577468

---

➶

reach

"However, Xagorari et al. [6] reported that luteolin inhibited NF-kappaB-mediated promoter activity by inhibiting IkappaBalpha degradation in LPS treated macrophage RAW 264.7 cells."

12963482

---

➶

reach

"Results showed that luteolin inhibited the downregulation of IkappaBalpha when compared to control cells."

26246742

---

➶

reach

"Correction : Digitoflavone Inhibits IkappaBalpha Kinase and Enhances Apoptosis Induced by TNFalpha through Downregulation of Expression of Nuclear Factor kappaB Regulated Gene Products in Human Pancreatic Cancer Cells."

| PMC

Lithium(1+) affects JUN

| 2 6

Lithium(1+) inhibits JUN. 8 / 8

| 2 6

---

➶

reach

"The specific effect of lithium on T91 and T93 phosphorylation, together with the evidence that the c-JunD95 mutant resumes GCG apoptosis in presence of lithium, is consistent with a model whereby lithium blocks c-Jun pro apoptotic activity by targeting the priming T95 phosphorylation event for T91 and T93 phosphorylation."

24113186

---

➶

medscan

"Yet, the mechanism by which lithium inhibits c-Jun activity remains to be elucidated."

24113186

---

➶

reach

"Yet, the mechanism by which lithium inhibits c-Jun activity remains to be elucidated."

24113186

---

➶

medscan

"The specific effect of lithium on T91/T93 phosphorylation, together with the evidence that the c-JunD95 mutant resumes GCG apoptosis in presence of lithium, is consistent with a model whereby lithium blocks c-Jun pro-apoptotic activity by targeting the priming T95 phosphorylation event for T91/T93 phosphorylation."

24113186

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➶

reach

"Here we show that lithium blocks the canonical c-Jun apoptotic pathway in cerebellar granule neurons deprived of trophic support."

12917327

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➶

reach

"Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3."

12917327

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➶

reach

"A further question addressed by our study is the mechanism through which lithium blocks c-Jun pro apoptotic function without inhibiting JNK activity."

24113186

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➶

reach

"In these same neurodegenerative disorders as well as in stroke, TBI and SCI, retinal degeneration, MS, and HIV, lithium inhibits glutamate induced excitotoxicity mediated by NMDA receptors, specifically attenuating the NR2B subunit constitutive tyrosine phosphorylation, and subsequent calcium influx, thus suppressing excitotoxicity induced p38 and c-Jun N-terminal kinase (JNK), and subsequent transcription factor activator protein-1 (AP-1) activation to block neuronal apoptosis."

27651765

Heparin affects FOS

| 8

Heparin inhibits FOS. 8 / 8

| 8

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➶

reach

"Because heparin is taken up by cells over a much longer time course, we addressed mechanisms whereby extracellular heparin might suppress c-fos induction at such early times."

8663360

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➶

reach

"We show that heparin suppressed the induction of c-fos and c-myc mRNA by serum in murine (BALB/c) 3T3 fibroblasts."

2541434

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➶

reach

"Heparin suppresses mitogenic responses in renal mesangial cells, and when quiescent mesangial cells are stimulated with serum, heparin blocks the induction of c-fos seen at 15 min."

8663360

---

➶

reach

"Inhibition of mitogenesis and c-fos induction in mesangial cells by heparin and heparan sulfates."

8821828

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➶

reach

"Previous experiments have shown that heparin inhibits induction of c-fos and c-myc protooncogene mRNA in rat VSMC stimulated by phorbol 12-myristate 13-acetate (PMA) but not when stimulated by epidermal growth factor (EGF) (Pukac, L. A., Castellot, J. J., Wright, T. C., Caleb, B. L., and Karnovsky, M. J. (1990) Cell Regul."

1371276

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➶

reach

"We conclude that heparin suppresses induction of c-fos in mesangial cells by blocking at least two different points in signal transduction cascades, one upstream of MAPK and the other independent of MAPK, but dependent on intracellular Ca2+."

8663360

---

➶

reach

"These results suggest that heparin inhibits a protein kinase C dependent pathway for cell proliferation and suppresses the induction of c-fos and c-myc mRNA at a site distal to activation of the kinase."

2541434

---

➶

reach

"In this paper we show that heparin suppressed the induction of c-fos and c-myc mRNA in rat and calf VSMC."

2099192

Doxorubicin affects NFKBIA

| 8

Doxorubicin inhibits NFKBIA. 8 / 8

| 8

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➶

reach

"More specifically, the knockdown of IKKalpha and IKKbeta blunted the ability of doxorubicin to initiate the degradation of IkappaBalpha as well as decreased the phosphorlyation of p65 at the serine536 residue following doxorubicin treatment."

18644995

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➶

reach

"Interestingly, the knockdown of either catalytic subunit resulted in an increase in IkappaBalpha at baseline (XREF_FIG) as well as a decrease in the doxorubicin induced degradation of IkappaBalpha (XREF_FIG)."

18644995

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➶

reach

"To this end, experiments were performed to determine whether doxorubicin induced degradation of IKB-alpha, an endogenous inhibitor of NF-kappaB translocation to the nucleus and subsequently NF-kappaB activity."

26921248

---

➶

reach

"Consistently with our previous findings in other cancer cells [XREF_BIBR], doxorubicin induced IkappaBalpha degradation, p65 nuclear localization and increased NF-kappaB -DNA binding in the triple negative MDA-MB-231 cells."

24344116

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➶

reach

"To determine whether low-dose doxorubicin upregulates NF-kappaB activity by facilitating IkappaBalpha degradation, the protein levels of cytosolic IkappaBalpha and nuclear NF-kappaB were determined by Western blotting."

12818362

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➶

reach

"Recently, it has also been shown that doxorubicin can initiate IkappaBalpha degradation and NF-kappaB activation independent of either IKKalpha or IKKbeta using the same in vitro models."

18644995

---

➶

reach

"In addition, pretreatment of wortmannin blocked etoposide and doxorubicin induced IkappaB-alpha degradation, NFkappaB activation, phosphorylation of Akt, MDM-2 and forkhead transcription factors."

17935137

---

➶

reach

"Doxorubicin activates NF-kappaB and induces IkappaBalpha degradation in HT1080 cells."

18644995

Dasatinib (anhydrous) affects MAPK14

8 |

Dasatinib (anhydrous) inhibits MAPK14. 8 / 8

8 |

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➶

tas

No evidence text available

---

➶

tas

No evidence text available

15615512

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➶

tas

No evidence text available

26789553

---

➶

tas

No evidence text available

17154512

---

➶

tas

No evidence text available

19462975

---

➶

tas

No evidence text available

19396179

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

18183025

Daidzein affects STAT1

| 8

Daidzein inhibits STAT1. 8 / 8

| 8

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➶

reach

"Anti-Inflammatory Effects of Flavonoids : Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-kappaB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-kappaB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages."

18274639

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➶

reach

"Daidzein and genistein also inhibited activations of STAT-1 and NF-kappaB, which are important transcription factors for iNOS [XREF_BIBR, XREF_BIBR]."

18274639

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➶

reach

"Similarly, in macrophage, daidzein inhibited the activation of STAT-1 and NF-kB proteins, thereby decreased the expression of iNOS and the production of NO [XREF_BIBR]."

22931352

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➶

reach

"The mechanisms by which genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 activation are not known, but may be associated with inhibition of phosphorylation of STAT-1 or its up-stream kinase JAK2 [XREF_BIBR]."

18274639

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➶

reach

"Flavonoids like genistein, kaempferol, quercetin, and daidzein inhibited STAT-1 and NF-kappa B activations in anti-inflammatory effects [XREF_BIBR]."

25183267

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➶

reach

"Genistein, kaempferol, quercetin, and daidzein also inhibited the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS."

18274639

---

➶

reach

"In addition, genistein, kaempferol, quercetin, and daidzein also inhibited STAT-1 activation."

18274639

---

➶

reach

"Daidzein also inhibits STAT-1 and NF-kappaB activations in an activated macrophage [XREF_BIBR]."

28831294

Cyclosporin A affects RELA

| 8

Cyclosporin A inhibits RELA. 8 / 8

| 8

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➶

reach

"To exam whether cyclosporine A (CsA) and a non immunosuppressive analog, sanglifehrin A (Sfa), could also suppress p65 and Rel A, we treated MEF with CsA (1.0 microM) and Sfa (100 nM) to inhibit CypA isomerase activity, followed by examining p65 and RelA expression levels in cytoplasmic and nuclear extracts."

25119989

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➶

reach

"To exam whether cyclosporine A (CsA) and a non immunosuppressive analog, sanglifehrin A (Sfa), could also suppress p65 and Rel A, we treated MEF with CsA (1.0 microM) and Sfa (100 nM) to inhibit CypA isomerase activity, followed by examining p65 and RelA expression levels in cytoplasmic and nuclear extracts."

25119989

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➶

reach

"CsA, which was added to HPTC simultaneously with the engagement of both CD3 and CD28 or the 1-h-delayed engagement of CD28 after prior TCR and CD3 triggering, inhibited NF-kappaB p65 and RelA from binding to the target DNA fragment, followed by reduction of HPTC proliferation in response to the costimulation."

15710339

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➶

reach

"Kinase inhibitors decreased nuclear p65 and DNA binding, in cells treated with CsA."

23958496

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➶

reach

"The phosphorylated forms of IKKgamma and NF-kappaB p65 were significantly reduced only in the low-salt fed rats treated with CsA, indicating greater NF-kappaB activation under these conditions (XREF_FIG)."

23057591

---

➶

reach

"CsA, which was added to HPTC simultaneously with the engagement of both CD3 and CD28 or the 1-h-delayed engagement of CD28 after prior TCR and CD3 triggering, inhibited NF-kappaB p65 and RelA from binding to the target DNA fragment, followed by reduction of HPTC proliferation in response to the costimulation."

15710339

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➶

reach

"We used anti-CD3 (OKT3) and anti-CD28 (28.2 or Leu28) for HPTC costimulation and found a rapid change of CsA sensitivity within 30 min after the costimulation.In summary, CsA that was added simultaneously with anti-CD3-anti-CD28 costimulation prevented nuclear factors NF-AT and NF-kappaB p65 and RelA from migrating into the nuclei, and the drug that was added 30 min after the costimulation lost its inhibitory effect only on NF-kappaB."

15710339

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➶

reach

"We used anti-CD3 (OKT3) and anti-CD28 (28.2 or Leu28) for HPTC costimulation and found a rapid change of CsA sensitivity within 30 min after the costimulation.In summary, CsA that was added simultaneously with anti-CD3-anti-CD28 costimulation prevented nuclear factors NF-AT and NF-kappaB p65 and RelA from migrating into the nuclei, and the drug that was added 30 min after the costimulation lost its inhibitory effect only on NF-kappaB."

15710339

Chloroquine affects IFNB1

| 8

Chloroquine inhibits IFNB1. 8 / 8

| 8

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➶

reach

"Supporting the specificity of dsRNA and LyoVec for RLRs, chloroquine (10 microg/ml) did not reduce IFN-beta or IFN-lambda 1 mRNA at 3 and 24 h (XREF_SUPPLEMENTARY)."

23658644

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➶

reach

"In contrast to USA300 XREF_BIBR, Ifnb induction by 502A was not inhibited by chloroquine, which indicated a lack of endosomal TLR involvement."

24586160

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➶

reach

"In our experiments, pre-treatment of PEM with either cytochalasin D, an inhibitor of actin polymerization and thus internalization, dynasore, an inhibitor of the endocytic effector dynamin, or chloroquine, which inhibits endosome acidification [30], [31], significantly impaired the induction of IFN-β following Listeria infection, strongly suggesting that phagocytosis of L. monocytogenes and intracellular location of TLR2 trigger this response."

22432012

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➶

reach

"IFN-beta synthesis was strongly diminished by both dynasore and chloroquine treatments."

22432012

---

➶

reach

"IFN-β synthesis was strongly diminished by both dynasore and chloroquine treatments."

22432012

---

➶

reach

"In our experiments, pre-treatment of PEM with either cytochalasin D, an inhibitor of actin polymerization and thus internalization, dynasore, an inhibitor of the endocytic effector dynamin, or chloroquine, which inhibits endosome acidification XREF_BIBR, XREF_BIBR, significantly impaired the induction of IFN-beta following Listeria infection, strongly suggesting that phagocytosis of L. monocytogenes and intracellular location of TLR2 trigger this response."

22432012

---

➶

reach

"Chloroquine attenuates TLR3 and IFN-beta signaling in cultured normal human mesangial cells : A possible protective effect against renal damage in lupus nephritis."

28150518

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➶

reach

"Chloroquine reduced IFN-beta mRNA at 24 h and more completely by 48 h (XREF_FIG) whereas IFN-lambda 1 was only inhibited by chloroquine at 48 h. However, chloroquine also inhibited viral replication at 24 and 48 h (XREF_SUPPLEMENTARY)."

23658644

Azithromycin affects NLRP3

| 8

Azithromycin inhibits NLRP3. 8 / 8

| 8

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➶

reach

"Our studies are unique in that NLRP3 mRNA expression is decreased in LPS stimulated monocytes treated with azithromycin."

28659178

---

➶

reach

"Azithromycin decreases NLRP3 mRNA by decreasing transcript stability."

28659178

---

➶

reach

"To determine if azithromycin reduces NALP3 protein at the pre-translational level, we assayed levels of its coding NLRP3 mRNA."

28659178

---

➶

reach

"Azithromycin increases NLRP3 mRNA degradation without altering NLRP3 promoter activity."

28659178

---

➶

reach

"In vitro, azithromycin and erythromycin inhibited NLRC4 and NLRP3 inflammasomes activation."

28684545

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➶

reach

"These data further support that azithromycin decreases NLRP3 mRNA stability; however, the inability of the antibiotic to totally abrogate NLRP3 mRNA 3 ' UTR activity in response to LPS may be related to the experimental conditions used or other regulatory response elements that are not contained within the fragment tested."

28659178

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➶

reach

"In assessing the kinetics for these anti-inflammatory effects of azithromycin, the compound decreased NALP3 expression in unstimulated THP-1 cells treated with azithromycin by 4-6h and LPS modestly increased NALP3 mass by 4-8h (Figs."

28659178

---

➶

reach

"Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome dependent inflammation."

28659178

Atorvastatin affects NLRP3

| 8

Atorvastatin inhibits NLRP3. 8 / 8

| 8

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➶

reach

"In the present study, we demonstrated that atorvastatin decreased the vulnerability of advanced atherosclerotic plaques, and inhibited the inflammatory response and the activation of NLRP3 inflammasomes, by inducing autophagy in ApoE -/- mice."

29773990

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➶

reach

"Atorvastatin Upregulated Autophagy Through the mTOR Pathway and Inhibited the Activation of NLRP3 Inflammasome in RAW264.7 Cells."

29773990

---

➶

reach

"Atorvastatin Significantly Inhibited the Activation of NLRP3 Inflammasomes."

29773990

---

➶

reach

"In vivo experiments confirmed that atorvastatin could inhibit the activation of NLRP3 inflammasomes and subsequent inflammation in atherosclerotic plaques."

29773990

---

➶

reach

"As shown in Figures XREF_FIG - XREF_FIG, western blotting and immunostaining showed that atorvastatin significantly reduced the abundance of NLRP3 in ox-LDL-induced macrophages."

29773990

---

➶

reach

"Atorvastatin could also inhibit NLRP3 inflammasome activation and inflammatory cytokines, such as IL-1beta, TNF-alpha, and IL-18 secretion in vivo."

29773990

---

➶

reach

"As shown in Figures XREF_FIG, atorvastatin significantly reduced the abundance of NLRP3 inflammasomes (p < 0.05)."

29773990

---

➶

reach

"In the present study, we found that atorvastatin suppressed NLRP3 inflammasome activation in vulnerable atherosclerotic plaques and in activated macrophages stimulated by ox-LDL."

29773990

Amlexanox affects IKBKE

| 1 7

Amlexanox inhibits IKBKE. 8 / 8

| 1 7

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➶

reach

"Amlexanox, which is known to inhibit TBK1 and IKKepsilon selectively, is an approved drug for the treatment of bronchial asthma, allergic rhinitis, and conjunctivitis in Japan and elsewhere."

29951055

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➶

eidos

"Consistent with this view , global knockout of the cGAS-cGAMP-STING downstream target TBK1 ( 37 ) or IRF3 ( 38 ) , or pharmacological inhibition of IkappaB kinase epsilon ( IKKepsilon ) and TBK1 by amlexanox , reduced body weight , enhanced insulin sensitivity , and improved glucose tolerance in obese mice and in a subset of patients with type 2 diabetes ( 34,39 ) ."

31109939

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➶

reach

"Amlexanox blocks activity of TBK1 and IKKepsilon with a half maximal inhibitory concentration (IC50) of approximately 1-2 muM."

30791439

---

➶

reach

"14 We found that amlexanox treatment could inhibit the IKBKE protein and alter the abundance and phosphorylation status of the Hippo pathway proteins in glioma cells."

29048430

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➶

reach

"Recently, amlexanox has been shown to inhibit TBK1 and IKKepsilon, both of which are induced in the liver and fat by high-fat diet mediated NF-kappaB activation [XREF_BIBR]."

27353409

---

➶

reach

"Amlexanox Amlexanox is an inhibitor of noncanonical IkappaB kinases IKK-epsilon and TANK binding kinase 1."

29247356

---

➶

reach

"Recently, Reilly et al. [XREF_BIBR] discovered a small molecule inhibitor of IKKepsilon and TBK1 kinases called amlexanox, which has been shown to selectively inhibit both IKKepsilon and TBK1."

27145266

---

➶

reach

"Amlexanox is a specific inhibitor of IKKepsilon and TBK1."

23396211

Oclacitinib affects JAK1

2 | 6

Oclacitinib inhibits JAK1. 8 / 8

2 | 6

---

➶

reach

"Oclacitinib inhibits JAK1 and JAK2 activation."

32548076

---

➶

reach

"Oclacitinib inhibited JAK1, JAK2, JAK3, and TYK2 by 50% at concentrations (IC 50 's) of 10, 18, 99, and 84nm, respectively."

24495176

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➶

tas

No evidence text available

---

➶

reach

"Oclacitinib selectively inhibits Janus kinase 1."

23829933

---

➶

reach

"Oclacitinib also inhibited the function of JAK1 dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC 50 's ranging from 36 to 249nm."

24495176

---

➶

reach

"Oclacitinib is a selective inhibitor of janus kinase 1."

30323921

---

➶

reach

"Oclacitinib is a Janus kinase (JAK) 1 enzyme inhibitor and blocks JAK1 dependent cytokines and is used to control pruritus."

31068210

---

➶

tas

No evidence text available

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects RELA

| 1 1 6

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits RELA. 8 / 8

| 1 1 6

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➶

sparser

"In contrast, MG-132 inhibits CDG-induced RelA, but not IRF3, nuclear translocation in BMDMs and BMDCs ( xref )."

24307739

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➶

reach

"Based on our results, NF-kappaB p65 expression was significantly blocked after treated with MG-132 and co-treatment with isoflurane and MG-132."

28539818

---

➶

reach

"We observed that DOX induces upregulation of the p65 gene, and that MG132, alone or in combination with DOX, downregulated p65."

24495648

---

➶

medscan

"Consistently, JQ1 induced the degradation of RelA, which was prevented by treatment with proteasome inhibitor MG-132 ( )."

23686307

---

➶

reach

"The expression of RelA was decreased after treated with MG-132 in DU145 cells transfected either with control-siRNA or RelB-siRNA in a time dependent manner."

21856005

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➶

reach

"In addition, in our study, MG-132, an NF-kappaB inhibitor, abrogated the upregulation of p65 and APE-1 mRNA and protein levels induced by MCP-1."

23525727

---

➶

reach

"Overexpression of PPP1R13L also depleted the cells of the NF-kappaB subunit, RelA, which again could be reversed by MG132."

19263435

---

➶

reach

"Western blot results showed that MG132 also degraded p65 (XREF_FIG) and Sp3 (DeltaSp3) (XREF_FIG) proteins."

| PMC

Arg-Val affects MAVS

| 8

Arg-Val inhibits MAVS. 8 / 8

| 8

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➶

reach

"Remarkably, mutagenesis of the SPLTSS motif to six alanines completely abolished RV-induced MAVS degradation (Figure 4G)."

30460894

---

➶

reach

"Similarly, only the two reassortant RVs derived from the cross of simian RRV and murine EW RVs, both of which encoded a murine RV VP3 (B7/2 and D6/2), were able to degrade murine MAVS in NIH3T3 cells as compared to WT RRV(Figure 3-figure supplement 1B, lower panel)Figure 2 continuedActive RV replication induces proteasomal degradation of MAVS."

30460894

---

➶

reach

"Of note, replication of a simian RV, which is unable to degrade murine MAVS, is significantly enhanced in Mavs-/- mice."

30460894

---

➶

reach

"Here, we found that MAVS, critical for the host RNA sensing pathway upstream of IFN induction, is degraded by the RV RNA methyl-and guanylyl-transferase (VP3) in a host-range-restricted manner."

30460894

---

➶

reach

"Here, we found that MAVS, critical for the host RNA sensing pathway upstream of IFN induction 3, is degraded by the RV RNA methyl- and guanylyl-transferase (VP3) in a host-range-restricted manner."

30460894

---

➶

reach

"Since MAVS acts upstream of both IRF3 and NF-kB signaling, we next examined the functional significance of RV-induced MAVS degradation."

30460894

---

➶

reach

"Since MAVS acts upstream of both IRF3 and NF-κB signaling, we next examined the functional significance of RV-induced MAVS degradation."

30460894

---

➶

reach

"In the present study, we report the unexpected discovery that the RV RNA capping enzyme VP3, an important RV structural protein, recently shown to also possess phosphodiesterase (PDE) activity , also mediates MAVS degradation in an RV strain-specific manner."

30460894

Wedelolactone affects IKBKB

1 | 2 3 1

Wedelolactone inhibits IKBKB. 7 / 7

1 | 2 3 1

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➶

reach

"As expected, staurosporine inhibited all kinase activity, and wedelolactone selectively inhibited IKKalpha and IKKbeta."

29374256

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➶

sparser

"As expected, staurosporine inhibited all kinase activity, and wedelolactone selectively inhibited IKKα and IKKβ."

29374256

---

➶

ctd

No evidence text available

25450232

---

➶

medscan

"Hsp90 inhibitor, 17-DMAG, more potently inhibited the NF-κB reporter than MLN-120b in UM-SCC1 cells, while UM-SCC11B cells were sensitive to both drugs ( ). 17-DMAG and Wedelolactone more potently inhibited cell proliferation in both cell lines, compared to inhibitor-kappaB kinaseβ selective inhibitors, MLN-120b and SC-514 ( )."

23455325

---

➶

sparser

"Wedelolactone also inhibits both IKKα and IKKβ through modulation of caspases and IκB phosphorylation ( xref )."

23455325

---

➶

sparser

"To determine if the rapid induction of apoptosis in macrophages and DC was NF-κB/IKK inhibition-dependent and not an off-target effect of TAT-NBD, five additional NF-κB inhibitory compounds were tested: Compound A (CmpA) and TPCA-1, both of which inhibit IKKβ; MG-132, which inhibits IκBα proteosomal degradation; and IKKiVII and Wedelolactone, which inhibit both IKKα and IKKβ (see xref )."

24406986

---

➶

medscan

"Wedelolactone also inhibits both inhibitor-kappaB kinaseα and inhibitor-kappaB kinaseβ through modulation of caspases and inhibitor kappaB phosphorylation ( )."

23455325

Wedelolactone affects CHUK

| 1 4 2

Wedelolactone inhibits CHUK. 7 / 7

| 1 4 2

---

➶

sparser

"Moreover, inhibition of IKKα by wedelolactone decreases the nuclear localization of AR and suppresses AR signaling xref ."

29142311

---

➶

medscan

"As indicated in , when H358 cells were pre-treated with Wedelolactone that inhibits the kinase activity of IKKα/β ( ) prior to Measles virus infection, there was a strong decrease in Measles virus N protein levels."

24503067

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➶

sparser

"To determine if the rapid induction of apoptosis in macrophages and DC was NF-κB/IKK inhibition-dependent and not an off-target effect of TAT-NBD, five additional NF-κB inhibitory compounds were tested: Compound A (CmpA) and TPCA-1, both of which inhibit IKKβ; MG-132, which inhibits IκBα proteosomal degradation; and IKKiVII and Wedelolactone, which inhibit both IKKα and IKKβ (see xref )."

24406986

---

➶

reach

"Moreover, inhibition of IKKalpha by wedelolactone decreases the nuclear localization of AR and suppresses AR signaling 29."

29142311

---

➶

sparser

"Wedelolactone also inhibits both IKKα and IKKβ through modulation of caspases and IκB phosphorylation ( xref )."

23455325

---

➶

sparser

"As expected, staurosporine inhibited all kinase activity, and wedelolactone selectively inhibited IKKα and IKKβ."

29374256

---

➶

reach

"As expected, staurosporine inhibited all kinase activity, and wedelolactone selectively inhibited IKKalpha and IKKbeta."

29374256

Tacrolimus (anhydrous) affects NFKB1

| 7

Tacrolimus (anhydrous) inhibits NFKB1. 7 / 7

| 7

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➶

reach

"The immunosuppressant FK506 activates NF-KB in fibroblasts and renal mesangial cells, which may be the mechanism underlying the nephrotoxic effects of this agent [35]."

9265727

---

➶

reach

"FK506 inhibits the nuclear factor of activated T cells (NF-AT) and NF-KB activation in T lymphocytes, suggesting that different tissues may respond differently to NF-KB inhibitors."

9265727

---

➶

reach

"Research findings show that the chronic administration of tacrolimus significantly reduces spontaneous optic neuropathy in p50 deficient mice."

21850191

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➶

reach

"FK506 caused a 30-40% reduction in nuclear p65 and a more pronounced reduction (70-80%) of nuclear cRel, p50, and NFATc."

12732617

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➶

reach

"Pre-treatment with tacrolimus markedly protected RGC-5 cells from NMDA induced neurotoxicity, and then both spontaneous RGC death and degenerative changes to the optic nerve in p50 deficient mice were significantly reduced by the chronic administration of tacrolimus."

21850191

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➶

reach

"Furthermore, FK506 inhibited nuclear factor-kappaB activation and decreased mRNA levels of the p50 and p65 subunits of nuclear factor-kappaB."

10406194

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➶

reach

"Tacrolimus also inhibits the activation of NFkB, which is strongly connected with the generation of ROS."

28356840

Staurosporine affects MAPK8

7 |

Staurosporine inhibits MAPK8. 7 / 7

7 |

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➶

tas

No evidence text available

22014755

---

➶

tas

No evidence text available

20472330

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

15711537

---

➶

tas

No evidence text available

28259529

---

➶

tas

No evidence text available

Sirolimus affects RELA

1 | 6

Sirolimus inhibits RELA. 7 / 7

1 | 6

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➶

reach

"We found that in HaCaT cells induced with TNF-I +/-, Rapamycin inhibited key steps in activation of central pro inflammatory factor NF-I (o) B : II (o) BI +/- phosphorylation and degradation; and nuclear translocation of total and phosphorylated NF-I (o) B protein p65 and RelA."

29596905

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➶

reach

"Moreover, immunofluorescent staining showed that rapamycin reduced the accumulation of p65 in the nucleus after ox-LDL treatment for 30 h. mTOR knockdown decreased LOX-1 protein production and IkappaBalpha phosphorylation induced by ox-LDL."

26752047

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➶

ctd

No evidence text available

22363816

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"The rapamycin treatment significantly decreased the level of phospho-NF-kappaB p65 protein in the IL-23-treated cells, suggesting that mTOR functioned as an upstream regulator to mediate NF-kappaB p65 activation in IL-23-stimulated TFCs."

29434604

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"Moreover, a combination of rapamycin (80 nM) and MPA (20 nM) inhibited the TNF-alpha-induced nuclear localization of NF-kappaB p65 in HaCaT cells when compared with individual drug treatments and other combinations of the two drugs."

25673929

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"We found that in HaCaT cells induced with TNF-I +/-, Rapamycin inhibited key steps in activation of central pro inflammatory factor NF-I (o) B : II (o) BI +/- phosphorylation and degradation; and nuclear translocation of total and phosphorylated NF-I (o) B protein p65 and RelA."

29596905

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"PCA, Bay 11-7085, Akt inhibitor, rapamycin and N -acetylcysteine inhibited lipopolysaccharide caused increase in the NF-kappaB p65 to DNA binding activity."

29291542

Simvastatin affects STAT1

1 | 6

Simvastatin inhibits STAT1. 7 / 7

1 | 6

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"A recent study reported that simvastatin, an HMG-CoA reductase inhibitor approved by the FDA for the treatment of hypercholesterolemia, inhibited IFN-gamma-induced STAT1 activation in vitro."

25521459

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"STAT1 is also phosphorylated by IL-12, a cytokine that induces IFN-gamma production, and certain STAT1 mutations in humans result in decreased IFN-gamma production after IL-12 stimulation, suggesting that STAT1 inhibition by simvastatin may have effects upstream of IFN-gamma production as well."

25521459

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ctd

No evidence text available

19886038

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"This is consistent with previous observations that the IFN-gamma-signaling pathway is critical for both the progression and maintenance of depigmentation in our mouse model), that STAT1 activation is required for IFN-gamma signaling, that simvastatin inhibits IFN-gamma-induced STAT1 activation in vitro, and that simvastatin reversed depigmentation in a patient with vitiligo."

25521459

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"Interestingly, simvastatin modulates the detrimental effects of high glucose and ANG II in diabetic kidney glomeruli both in vitro and in vivo by preventing the high glucose and ANG II induced geranylgeranyl dependent activation of Rac or/and Rho and thereby blocking the activation of JAK2 and both STAT1 and STAT3 [XREF_BIBR]."

32375786

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"Activation of signal transducer and activator of transcription 1 (STAT1) is required for IFN-gamma signaling and recent studies revealed that simvastatin, an FDA approved cholesterol lowering medication, inhibited STAT1 activation in vitro."

25521459

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➶

reach

"STAT1 activation is required for IFN-gamma signaling and recent studies revealed that simvastatin, an FDA approved cholesterol lowering medication, inhibited STAT1 activation in vitro."

25521459

Resveratrol affects TICAM1

| 7

Resveratrol inhibits TICAM1. 7 / 7

| 7

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"28 Resveratrol, an antioxidant found in red wine, inhibits TRIF dependent activation, 29 and, like GA, reduces clinical EAE and macrophage mediated inflammatory activity."

26601118

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"Furthermore, the suppressive effect of resveratrol on LPS induced NF-kappaB activation was abolished in TRIF deficient mouse embryonic fibroblasts, but not in MyD88 deficient macrophages (XREF_FIG), suggesting that resveratrol specifically inhibits MyD88 independent signaling pathways downstream of TLR3 and TLR4."

21631512

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"Resveratrol inhibits the TRIF dependent pathway by upregulating sterile alpha and armadillo motif protein, contributing to anti-inflammatory effects after respiratory syncytial virus infection."

24478430

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reach

"We hypothesize that resveratrol inhibits the TRIF dependent pathway through upregulation of SARM post-RSV infection."

24478430

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"Together, these results demonstrate that resveratrol specifically inhibits TRIF signaling in the TLR3 and TLR4 pathway by targeting TANK binding kinase 1 and RIP1 in TRIF complex."

16116226

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"The suppressive effect of resveratrol on LPS induced NF-kappaB activation was abolished in TRIF deficient mouse embryonic fibroblasts, whereas LPS induced degradation of IkappaBalpha and expression of cyclooxygenase-2 and inducible NO synthase were still inhibited in MyD88 deficient macrophages."

16116226

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"Resveratrol specifically inhibits TRIF signaling in the TLR3 pathway by targeting TBK1 and RIP1 in TRIF complex, resulting in inhibition of pro inflammatory cytokines expression [XREF_BIBR]."

29050325

Reactive oxygen species affects RELA

| 7

Reactive oxygen species inhibits RELA. 7 / 7

| 7

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"The ROS inducing effects and the NF-kappaB inhibitory effects decreased the activity of the nuclear p65, affected cell cycle progression, and induced cell death in cancer cells."

25663936

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"In line with these reports, our results have revealed that PGE treatment contributed to the improvement in hyperlipidemia as a result of a reduction in ROS mediated p65 induction of miR-145 expression in alloxan-diabetic rats."

29105385

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"We found that TNF-alpha-induced NF-kappaB and RelA Ser (276) phosphorylation, a modification critical for its transcriptional activity, was inhibited by abrogation of the ROS signaling pathway, whereas NF-kappaB and RelA Ser (536) phosphorylation was not."

17317104

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"In addition, physalin F abrogated the nuclear translocation of p65 and p50 subunits that were reversed by both ROS scavengers, NAC and GSH (XREF_FIG)."

22815798

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"Thus, these analogs exert antiproliferative effects through two independent mechanisms of action, acting both as ROS inducing agents and NF-kappaB p65 inhibition in TNBC cells."

28373422

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"In our study, NAC pretreatment improved total and phospho-NF-kappaB p65 and RelA expression, indicating that excessive ROS inhibited p65 and RelA production directly."

27010086

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"In our study, NAC pretreatment improved total and phospho-NF-kappaB p65 and RelA expression, indicating that excessive ROS inhibited p65 and RelA production directly."

27010086

Quercetin affects STAT1

| 7

Quercetin inhibits STAT1. 7 / 7

| 7

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"Inhibition of STAT-1 activation by quercetin is likely involved in the mechanisms by which it inhibits iNOS expression because JAK inhibitors AG-490 and WHI-P154 have been shown to inhibit iNOS expression along with their suppressive actions on STAT-1 activation [XREF_BIBR, XREF_BIBR]."

18274639

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"The mechanisms by which genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 activation are not known, but may be associated with inhibition of phosphorylation of STAT-1 or its up-stream kinase JAK2 [XREF_BIBR]."

18274639

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"Flavonoids like genistein, kaempferol, quercetin, and daidzein inhibited STAT-1 and NF-kappa B activations in anti-inflammatory effects [XREF_BIBR]."

25183267

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"In addition, genistein, kaempferol, quercetin, and daidzein also inhibited STAT-1 activation."

18274639

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"Anti-Inflammatory Effects of Flavonoids : Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-kappaB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-kappaB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages."

18274639

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"Genistein, kaempferol, quercetin, and daidzein also inhibited the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS."

18274639

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reach

"The quercetin induced activation of STAT1 inhibited cell proliferation, which may lead to the observed potentiation of the IFN-alpha-induced antiproliferative effect in HepG2 and Huh7 cells."

29371942

Potassium(1+) affects CASP1

| 1 6

Potassium(1+) inhibits CASP1. 7 / 7

| 1 6

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medscan

"Preventing the potassium efflux by increasing extracellular potassium concentrations inhibits caspase-1 activation in response to stimuli that activate Nlrp3."

23954133

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"Addition of extracellular potassium or the reactive oxygen scavenger NAC, both of which can prevent activation of the NLRP3 inflammasome, did not prevent activation of caspase-1 in response to infection with either the T3SS or the WT Yersinia strains (XREF_FIG and data not shown)."

20478539

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"Our data demonstrate that an excess of extracellular potassium prevents adenosine dependent activation of caspase-1 as does the use of the K ATP channel blocker glyburide."

24907587

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"As shown in Figure XREF_FIG, S. pneumoniae D39 induced caspase-1 activation was decreased by high extracellular potassium."

26683708

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"When eATP binds to the P2X7 receptor, intracellular potassium concentration decreases, causing caspase-1 to switch from being a protective agent involved in enhancing cell survival to being the source of a suicide pathway determining cell fate by pyroptosis [XREF_BIBR, XREF_BIBR]."

21675943

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"Studies have also shown that high levels of extracellular potassium in macrophages inhibit the activation of caspase-1 in those inflammasomes that require ASC [XREF_BIBR]."

22194672

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reach

"For example, high potassium (150 mM) has been shown to suppress activation and cleavage of recombinant caspase-1 in vitro XREF_BIBR."

22606244

Phorbol 13-acetate 12-myristate affects JUN

| 1 6

Phorbol 13-acetate 12-myristate inhibits JUN. 7 / 7

| 1 6

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"TPA did also repress the action of c-Jun in a promoter context other than the h ME, suggesting a complex regulation by interactions of these and, probably, other TPA regulated proteins.T3 receptors (TRs) belong to the class II ligand activated nuclear receptor superfamily that heterodimerize with RXR and characteristically bind with a high affinity to DNA hexameric half-sites, variants of the consensus AGGTCA, organized as direct repeats separated by a 4-bp intervening sequence (DR4) (Mangelsdorf et al., 1995)."

9889342

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"This may be because UA and UA+CG were the most potent inhibitors of DMBA and TPA induced c-jun positive cells and p50 positive cells of the treatments tested."

23835587

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"Although SAG Tg expression has no detectable effect on epidermis development and proliferation under unstressed conditions, it inhibits TPA induced epidermal proliferation by targeting c-Jun for degradation 164."

23528706

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reach

"IL-1 promotes the prolonged accumulation of Jun B, whereas the cellular content of Jun B decreases dramatically after 6 hr in cells treated with only TPA."

7675040

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➶

reach

"Rhein inhibits TPA induced activator protein-1 activation and cell transformation by blocking the JNK dependent pathway."

12632075

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reach

"When overexpressed, SAG remarkably reduced both basal and TPA induced c-Jun levels, whereas SAG small interfering RNA (siRNA) silencing increased substantially the levels of both basal and TPA induced c-Jun."

17440073

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sparser

"We further show that overexpression of Trespin in HEK293 cells enhances cell growth and prevents the inhibition of cell growth and phosphorylation of c-Jun by the phorbol ester TPA."

12651162

Okadaic acid affects NFKBIA

| 7

Okadaic acid inhibits NFKBIA. 7 / 7

| 7

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"However, the NFkappaB activation and IkappaBalpha degradation induced by OA are temporally delayed compared to those in LPS or TNF stimulated neutrophils (Figs. 1 and 2), or compared to the NFkappaB activation induced by OA in human monocytes [39] or promyelocytic HL-60 cells [40]."

12921778

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➶

reach

"In human neutrophils and HL-60 cells, OA and orthovanadate, an inhibitor of tyrosine phosphatase, stimulated the activation of NF-kappaB and rapid degradation of IkappaBalpha."

23591640

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reach

"The amounts of IkappaBalpha decreased in MG63 cells treated with OA for 2 h in a dose dependent fashion up to 100 nM (data not shown)."

23591640

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reach

"As shown in Fig. 3C, OA drastically inhibited the serine/threonine phosphatase activity, correlating with the induction of NFkappaB DNA binding and nuclear IkappaBalpha degradation.Next, we sought to determine whether the mechanism of the decreased IkappaBalpha protein levels in OA stimulated neutrophils consisted of the inhibition of IkappaBalpha re-synthesis induced by TNF or whether OA induces IkappaBalpha degradation."

12921778

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reach

"Therefore, we evaluated the effect of Wogonin on the degradation of IkappaBalpha and found that stimulation of OA chondrocytes with IL-1beta alone caused degradation of IkappaBalpha within 15 min of treatment, and was not blocked by treatment with Wogonin indicating that Wogonin mediated suppression of IL-6, COX-2, iNOS and MMPs was not due to the inhibition of the activation of NF-kappaB in IL-1beta-stimulated OA chondrocytes."

28237856

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"Therefore, we evaluated the effect of Wogonin on the degradation of IkappaBalpha and found that stimulation of OA chondrocytes with IL-1beta alone caused degradation of IkappaBalpha within 15 minutes of treatment, and was not blocked by treatment with Wogonin indicating that Wogonin mediated suppression of IL-6, COX-2, iNOS and MMPs was not due to the inhibition of the activation of NF-kappaB in IL-1beta-stimulated OA chondrocytes."

28237856

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➶

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"Stimulation of OA chondrocytes with AGE-BSA induced the degradation of cytoplasmic IkappaBalpha and increased the nuclear level of NF-kappaB subunits p65 and Rel-B (XREF_FIG)."

22982228

Nigericin affects CASP1

| 7

Nigericin inhibits CASP1. 7 / 7

| 7

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"Downregulated platelet caspase-1 activity in platelet specific TLR4 knockout mice was significantly reversed by the NLRP3 activator Nigericin, which did not occur in platelets derived from TLR4 Flox controls (XREF_FIG), indicating that activation of platelet NLRP3 is mediated via TLR4."

30522866

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reach

"As 2 O 3 and NaAsO 2 inhibited nigericin mediated caspase-1 processing and IL-1beta maturation (XREF_FIG)."

24337744

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reach

"POP2 expression reduced nigericin mediated caspase-1 activation from 19.6 to 5.4% of cells, which is only slightly less potent than the 1.4% of cells that we observed in Asc -/- BMDM."

28580931

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"Although nigericin stimulated caspase-1 activation and activity are only modestly attenuated in caspase-8-deficient (Casp8 (-/-) Rip3 (-/-)) BMDC, these cells do not exhibit the rapid loss of viability of WT cells."

26100631

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➶

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"In fact, caspase-1 deficiency impaired plasma membrane permeabilization induced by nigericin (XREF_FIG), meanwhile melittin induced plasma membrane permeabilization was independent on caspase-1 (XREF_FIG)."

28796264

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reach

"TRP blockers are also effective in inhibiting monosodium urate (MSU) crystal- and nigericin induced caspase-1 activation, but the specific involvement of TRP channels, particularly of TRPV2, in NLRP3 activation has still to be confirmed using genetic ablation in mouse models [XREF_BIBR]."

25644504

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"Second, HA tagged HSP70 transfected in murine BMDMs triggered a decrease in ATP and nigericin induced caspase-1 activation and IL-1beta maturation, as compared to HA-empty vector transfected cells."

30874540

Morphine(1+) affects RELA

| 1 6

Morphine(1+) inhibits RELA. 7 / 7

| 1 6

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"In keeping with the results of morphine down-regulated p65 in BV2 and PM cells, transcription of p65 in PM and BMM cells and translation of p65 in BV2 cells were also significantly reduced with various time periods (XREF_FIG)."

25539811

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➶

reach

"Therefore, our data suggest that miR-124 is required for morphine mediated inhibition of p65 and TRAF6."

25539811

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➶

reach

"Furthermore, as compared with the control group, morphine stimulation significantly decreased phospho-NF-kappaB p65 and NF-kappaB p65 in monocytes in a time- and concentration dependent manner (XREF_FIG)."

26978739

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➶

reach

"This is supported by the immunoblot result that morphine down-regulated proteins TRAF6 and p65 both in vitro and in vivo, suggesting that long-term morphine exposure attenuates the immune function of microglia in the CNS."

25539811

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➶

reach

"Morphine inhibits p65 and TRAF6 through miR-124."

25539811

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➶

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"Morphine inhibits p65 and TRAF6 through miR-124."

25539811

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reach

"XREF_FIG, co-administration of the morphine with the pioglitazone (40mg/kg) attenuated the spinal NF-kappaB p65 activity significantly compared with the control group (p < 0.001)."

26394827

Metformin affects RELA

| 7

Metformin inhibits RELA. 7 / 7

| 7

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"Immunofluorescence staining and western blot analysis showed that metformin inhibited the nuclear localization of p65, a subunit of nuclear factor NF-kappaB."

30520054

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➶

reach

"The suppression of NFkappaB p65 (XREF_FIG) and IL-8 (XREF_FIG) by metformin was not altered by addition of compound C. On the other hand, compound C blocked a large portion of metformin caused decrement in ICAM-1 expression (XREF_FIG; 70%; p < 0.05 versus metformin plus TNFalpha group)."

29513760

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➶

reach

"Metformin combined with CO-1686 synergistically inhibited the p-IkappaB, p-IKKa and beta, p50 and p65."

30307719

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➶

reach

"In addition, metformin nearly abrogated the binding of NF-kappaB subunit p65 to the iNOS promoter gene in lung tissue of obese mice."

24204674

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➶

reach

"In our study, metformin exerted anti-inflammatory effects by concentration-dependently reducing the production of pro inflammatory cytokines via suppression of IkappaBalpha phosphorylation and translocation of NF-kappaB p65 from cytosol to the nucleus."

24009539

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➶

reach

"As in LNCaP cells, metformin activated p-AMPK and reduced p65 and promoted cell death in MCF-7 cells."

26359363

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➶

reach

"Similarly, over-expression of N-cadherin in MCF-7 cells prevented metformin mediated inhibition of p65 and led to resistance to metformin mediated cell death in MCF-7 cells."

26359363

Luteolin affects RELA

| 7

Luteolin inhibits RELA. 7 / 7

| 7

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"These data together suggested that luteolin treatment inhibited the activation of p65, leading to the loss of cyclin D1, an NF-kB target gene."

21792893

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➶

reach

"Kao et al. found that luteolin decreased the LPS and IFN-gamma-induced nuclear accumulation of p65 and Rel B but not p50, suggesting partial inhibition of NF-kappaB activation in BV-2 microglial cells (Kao et al., 2011)."

29801717

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➶

reach

"Furthermore, luteolin decreased nuclear accumulation of p65 induced by TBI, indicating attenuation of inflammation."

25093609

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➶

reach

"Immunocytochemistry results revealed luteolin can inhibit TNF-alpha-stimulated p65 from nuclear translocation as a transcription factor and thus promoting cell apoptosis."

22803372

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➶

reach

"Our report demonstrated that luteolin inhibited the interaction of p65 with CBP and that this event was directly related to the inhibition of NF-kappaB transcriptional activity."

12963482

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➶

reach

"also observed that luteolin treated cells showed decreased IkappaBalpha degradation induced by TNF-alpha and significantly decreased NF-kappaB p65 nuclear translocation (Jia et al., 2015)."

29801717

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➶

reach

"Further findings demonstrated that luteolin inhibited the activation of ERK, JNK, p38, and NF-kappaB p65 in the IL-33-stimulated HMC-1.2 cells."

32197229

Glucose affects RELA

| 7

Glucose inhibits RELA. 7 / 7

| 7

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"As shown in XREF_FIG, HG enhanced the nuclear and decreased the cytoplasmic localization of NFkappaB p65 (P < 0.05)."

26379423

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➶

reach

"Compared with the control, HG treatment for 30 min resulted in significantly increased p65 contents in the nucleus and decreased p65 contents in the cytoplasm in GMCs (P < 0.05, XREF_FIG B and 5 C)."

22937115

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➶

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"Additionally, we found that TAK-242 treatment significantly suppressed the TLR4 and NF-kappaB pathway in HG induced podocytes by reducing the protein level of TLR4, p-IkappaBalpha and IkappaBalpha ratio and p-p65 and p65 ratio."

29604956

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➶

reach

"Hence, defective macroautophagy is not responsible for the demise of glucose starved RelA deficient cells."

21968997

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➶

reach

"Like GFP-Cx43, transfection with Flag-Cx43CT also significantly inhibited high glucose induced NF-kappaB p65 nuclear translocation (P < 0.05; Figures XREF_FIG B)."

23718910

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➶

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"This resulted in a marked decrease of ATP levels in glucose starved RelA deficient cells, but not in starved wild-type cells (XREF_FIG and XREF_SUPPLEMENTARY)."

21968997

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➶

reach

"alpha-T and alpha-TP attenuated high glucose and hypoxia induced cell apoptosis by promoting Bcl-2 and Akt and inhibiting nuclear factor kappaB p65, JNK, Notch-1, and p38MAPK genes."

28571880

Glucose affects NFKBIA

| 7

Glucose inhibits NFKBIA. 7 / 7

| 7

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"Interestingly, HG treatment also induced increased CIKS association with IKKgamma (data not shown) Thus HG induced IkappaB-alpha degradation and NF-kappaB activation were CIKS dependent."

23085260

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➶

reach

"Importantly, CIKS knockdown inhibited HG induced IkappaB-alpha degradation (XREF_FIG), and p65 nuclear translocation (XREF_FIG)."

23085260

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➶

reach

"Additionally, we found that TAK-242 treatment significantly suppressed the TLR4 and NF-kappaB pathway in HG induced podocytes by reducing the protein level of TLR4, p-IkappaBalpha and IkappaBalpha ratio and p-p65 and p65 ratio."

29604956

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➶

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"These data suggested that high glucose, but not osmotic pressure, induced the degradation of IkappaBalpha and activated NF-kappaB inflammatory signaling."

29038616

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➶

reach

"XREF_FIG showed that pretreatment with C66 dose-dependently reversed the HG induced degradation of IkappaBalpha (P < 0.01)."

24260158

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➶

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"High glucose induced degradation of IkappaBalpha and activation of NF-kappaB."

24991536

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➶

reach

"These results confirmed that administration of As-IV suppressed high glucose induced increase of TLR4 and NF-kappaB and decrease of IkappaBalpha."

30906223

Ethanol affects FOS

| 7

Ethanol inhibits FOS. 7 / 7

| 7

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"The acute EtOH induced c-fos induction in the medial Amy was inhibited by the MEK inhibitor, U0126 238."

26809997

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➶

reach

"Ethanol also inhibited the Ca2 (+)-dependent induction by anti-IgM of c-fos in these cells."

1324242

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reach

"We have previously reported that rats selectively bred for alcohol preference show altered Arrb2 mRNA levels in several brain regions compared to their non preferring counterparts, and mice lacking the Arrb2 gene exhibit reduced alcohol induced locomotion and c-fos activation in the shell of nucleus accumbens in response to a low dose of alcohol, suggesting impaired alcohol reward."

23779257

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➶

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"Using slot-blot hybridization, significant induction of c-fos mRNA after restraint stress was demonstrated both in hippocampus and cortex, but prior alcohol exposure specifically attenuated c-fos induction only in the hippocampus."

7823175

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➶

reach

"Whereas administration of EtOH per se decreased slightly the number of c-Fos + cells compared to sal-S (18.5 +/- 0.5 cFos + neurons/10 4 mum 2), eth-TBI mice displayed a marked decrease in the number of c-Fos + cells compared to sal-TBI (22.7 +/- 2.1 cFos + neurons/10 4 mum 2, p < 0.01 vs sal-TBI; Fig. 2 C, D)."

29306704

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➶

reach

"Acute administration of alcohol blocks cocaine induced striatal c-fos immunoreactivity protein in the rat."

7839314

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➶

reach

"Acute ethanol exposure significantly reduced the number of orexin neurons containing c-Fos, suggesting an inhibition of orexin neurons after ethanol intake."

24587575

Dihydrogen affects NLRP3

| 7

Dihydrogen inhibits NLRP3. 7 / 7

| 7

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"XREF_BIBR A current investigation reported that hydrogen could inhibit the activation of NLRP3 inflammasome in AD brains."

30713672

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➶

reach

"Hydrogen Rich Saline Attenuated Subarachnoid Hemorrhage Induced Early Brain Injury in Rats by Suppressing Inflammatory Response : Possible Involvement of NF-kappaB Pathway and NLRP3 Inflammasome."

26091790

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➶

reach

"Molecular hydrogen inhibits lipopolysaccharide triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species."

26488087

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➶

reach

"In an in vitro study, ROS inhibitors blocked priming, but not activation of the NLRP3 inflammasome XREF_BIBR, which may support that hydrogen rich water can not block activation of NLRP3 inflammasomes."

24985521

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➶

reach

"Hydrogen Rich Saline Inhibits NLRP3 Inflammasome Activation and Attenuates Experimental Acute Pancreatitis in Mice."

25214720

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➶

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"Our findings have, for the first time, revealed the novel mechanism underlying the inhibitory effect of molecular hydrogen on LPS caused NLRP3 inflammasome activation, highlighting the promising application of this new antioxidant in the treatment of LPS associated inflammatory pathological damage."

26488087

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➶

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"Hydrogen promoted autophagy related protein expression, inhibited the inflammasome NLRP3 pathway activation, and relieved the hyperpathia induced by neuropathic pain."

31689487

Cycloheximide affects NFKBIA

| 7

Cycloheximide inhibits NFKBIA. 7 / 7

| 7

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"The decrease was not observed when IkappaBalpha resynthesis was inhibited by cycloheximide."

10340762

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➶

reach

"We examined the possibility of Casp12 on the post-translational degradation of IkappaBalpha, NPC cells were treated with cycloheximide (CHX) in the presence and absence of Z-ATAD-fmk for the indicated time."

28380444

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➶

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"We measured expression of endogenous IkappaBalpha in C2C12 cells by inducing with TNF-alpha or taxol in medium to which 100 microg/ml cycloheximide (CHX) had been added in order to prevent synthesis of new IkappaBalpha (XREF_FIG)."

19732770

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"The 60-min nadir is due to a rapid IkappaBalpha resynthesis that reassociates with Rel A and completely inhibits its DNA binding activity; the 60-min nadir is not observed when IkappaBalpha resynthesis is prevented by cycloheximide treatment."

9092517

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"In addition, cycloheximide suppressed IkappaBalpha resynthesis and prolonged p38MAP kinase activation and these changes were associated with sustained activation of the transcription factor NF-kappaB."

15034930

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reach

"We found that SCF in presence of cycloheximide, a protein-biosynthesis inhibitor, induces IkappaBalpha degradation (data not shown)."

26353931

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"Consistent with endogenous activation of NF-kappaB signaling by taxol we showed that, similar to TNF-alpha, taxol treatment in the presence of cycloheximide significantly reduced IkappaBalpha suggesting that both molecules induce proteasomal degradation of IkappaBalpha."

19732770

Curcumin affects FOS

| 7

Curcumin inhibits FOS. 7 / 7

| 7

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"XREF_FIG shows that curcumin selectively inhibits the transcriptional activity of c-Jun and c-Fos but not c-Jun and Fra -1 in the absence of exogenous Zac1 (XREF_FIG; closed bars)."

26633653

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➶

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"Most interestingly, curcumin can reverse the expression dynamics of c-fos and fra-1 in this tumorigenic cell line, mimicking the expression pattern observed in normal controls or precancerous lesions."

15514944

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reach

"Curcumin can also reverse the expression dynamics of c-fos and fra-1 in tumorigenic HeLa cells by mimicking their expression pattern in normal cells."

| PMC

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➶

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"In this study, we show that curcumin decreases the TPA- induced c-Fos elevation in the nuclear extracts in spite of the slight super-induction of c-fos mRNA."

7553596

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➶

reach

"Curcumin at 20/^ M inhibited nearly all the TEA induction of c-Fos elevation."

7553596

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➶

reach

"Curcumin could attenuate the activation of p-ERK, p-CREB, c-fos in dorsal root ganglion to ameliorate the CCI induced neuropathic pain."

21155252

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➶

reach

"Furthermore, curcumin reduced the intracellular signaling proteins Ras, B-raf, p-MEK, p-ERK, c-fos, Egr-1, but increased Raf-1 and NAB2 in MDCK cells exposed to forskolin."

21187084

Cocaine affects FOS

1 | 6

Cocaine inhibits FOS. 7 / 7

1 | 6

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➶

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"Brain changes reported in homozygous 5-HT 1B KO mice do include reduced 5-HT levels, increased DA levels, and enhanced cocaine induced DA release in nucleus accumbens XREF_BIBR; reduced striatal SERT binding XREF_BIBR; reductions in 5-HT 2C receptor function XREF_BIBR; reduced cocaine induced c-fos elevation XREF_BIBR; and changes in several other receptor systems XREF_BIBR."

25514162

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➶

reach

"Both MK801 and SCH23390 pre-treatments blocked acute cocaine induced c-Fos protein induction [P < 0.05]."

18822274

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➶

ctd

No evidence text available

11421588

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➶

reach

"In this regard, the results showed that adolescent cocaine exposure did not modulate cell proliferation (Ki-67+ cells) or c-Fos protein activation in the dentate gyrus region of the hippocampus, but attenuated c-Fos activation in the dorsal striatum."

30484727

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➶

reach

"Repeated cocaine self administration also decreased c-Fos immunolabeling in the PVH, while repeated injections had no effect on c-Fos in this region."

26525566

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➶

reach

"We observe enhanced cocaine reward when D1+ MSNs are activated optogenetically and when TrkB is deleted selectively from them, however, the latter results in decreased c-Fos induction by cocaine without a significant change in baseline neuronal excitability."

20947769

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➶

reach

"Since many acute behavioral responses to cocaine can require appropriate c-fos activation, it follows that loss of MSK1, which reduces cocaine induced H3 phosphorylation in striatum, as well as subsequent cocaine mediated locomotor sensitivity, results in the loss of cocaine mediated c-fos transcriptional activity."

21272014

Cisplatin affects NFKBIA

| 3 4

Cisplatin inhibits NFKBIA. 7 / 7

| 3 4

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➶

sparser

"We found that fucoxanthin pretreatment attenuated cisplatin-induced DNA-binding activity of NFκB, restored cisplatin-inhibited IκB-α - phosphorylation, and increased the ratio of Bax/Bcl-2 mRNA expression, rendering cancer cells sensitive to apoptosis induced by cisplatin."

23299493

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➶

reach

"As shown in Figs. 5 and 6, neither doxorubicin- nor cisplatin induced marked IkappaBalpha degradation or accumulation of nuclear NF-kappaB."

12818362

---

➶

reach

"Recently, Kim et al. reported that cisplatin induces IkappaBalpha degradation, leading to the NF-kappaB-dependent up-regulation of TNF-alpha in HNSCC cells."

19852930

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➶

reach

"This conclusion was supported by the following observations : cisplatin induced IkappaBalpha degradation and NF-kappaB-dependent transcriptional activation prior to cell death; pyrrolidine dithiocarbamate (PDTC), a chemical inhibitor of NF-kappaB activation, prevented apoptosis; lactacystin, an inhibitor of IkappaBalpha degradation, also prevented apoptosis; and finally, the expression of a super repressor mutant IkappaBalpha blocked apoptosis."

16376337

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➶

sparser

"In addition, fucoxanthin significantly and concentration-dependently restored cisplatin-inhibited IκB-α - phosphorylation in HepG2 cells at 24 h of incubation, as compared with cisplatin treatment alone ( xref D)."

23299493

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➶

sparser

"Liu et al. [ xref ] showed that fucoxanthin pretreatment attenuated the cisplatin-induced DNA-binding activity of NF-κB, restored cisplatin-inhibited IκB-α - phosphorylation, and increased the ratio of Bax/Bcl-2 mRNA expression rendering cancer cells sensitive to apoptosis induced by cisplatin, which suggested that fucoxanthin may be an NF-κB inhibitor."

24322524

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➶

reach

"It was also shown that RA inhibits cisplatin induced IkappaBalpha degradation (XREF_FIG)."

21526214

Butorphanol affects ITCH

| 7

Butorphanol inhibits ITCH. 7 / 7

| 7

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➶

reach

"Since butorphanol was able to attenuate cowhage itch intensity by 35%, we were interested to investigate whether significant effects in brain perfusion were correlated with the reduction of itch, comparing (cowhage itch + drug) vs. (cowhage + placebo) conditions."

25211175

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➶

reach

"In conclusion, important relays of the mesolimbic circuit were involved in the inhibition of itch by butorphanol and could represent potential targets for the development of antipruritic therapy."

25211175

---

➶

reach

"Butorphanol Suppression of Histamine Itch is Mediated by Nucleus Accumbens and Septal Nuclei."

25211175

---

➶

reach

"Administered intranasally at doses ranging from 1 to 4 mg daily, butorphanol has reduced itch and improved sleep in the setting of prurigo nodularis, primary biliary cirrhosis, and lymphoma."

27011178

---

➶

reach

"Butorphanol suppression of histamine itch is mediated by nucleus accumbens and septal nuclei : a pharmacological fMRI study."

25211175

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➶

reach

"We found that i.t. injection of butorphanol (2 nmol) significantly reduced CQ induced scratching behaviors in WT, but not in Oprk1 -/- mice (XREF_SUPPLEMENTARY), suggesting that butorphanol inhibits CQ itch via a KOR dependent mechanism."

29669290

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➶

reach

"Intranasal butorphanol has been used successfully to treat severe cases of chronic pruritus, and administered epidurally, butorphanol blocks the itch induced by the epidural injection of morphine."

25211175

Bortezomib affects TRAF6

| 7

Bortezomib inhibits TRAF6. 7 / 7

| 7

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➶

reach

"These results illustrate that bortezomib can inhibit the activation of TRAF6 and NF-kappaB activity in SAS cells."

29703234

---

➶

reach

"Cytotoxic effects of bortezomib in myelodysplastic syndrome and acute myeloid leukemia depend on autophagy mediated lysosomal degradation of TRAF6 and repression of PSMA1."

22685174

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➶

reach

"It has been reported that bortezomib can induce proteasome independent degradation of TRAF6 in myelodysplastic syndrome [XREF_BIBR]."

29703234

---

➶

reach

"Paradoxically, we find that bortezomib induces proteasome independent degradation of the TRAF6 protein, but not mRNA, in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) cell lines and primary cells."

22685174

---

➶

reach

"To determine whether degradation of TRAF6 by bortezomib occurs via UPS, a proteasome inhibitor (MG132) was evaluated."

29703234

---

➶

reach

"Bortezomib inhibits activation of TRAF6 and NF-kappaB activity."

29703234

---

➶

reach

"Bortezomib inhibits maturation and function of osteoclasts from PBMCs of patients with multiple myeloma by downregulating TRAF6."

18778854

Berberine affects JUN

| 1 6

Berberine inhibits JUN. 7 / 7

| 1 6

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➶

reach

"The results of this study demonstrated that RC extract and berberine inhibit the production of monocyte chemoattractant protein 1 (MCP-1 and CCL2) in macrophages, likely via inhibition of the transcription factors activator protein 1 (AP-1) and nuclear factor-kappaB (NFkappaB)."

27774066

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➶

reach

"Fukuda et al. [13] reported that berberine inhibits the activity of activator protein 1 (AP-1), which transactivates inflammatory cytokines such as IL-6 [14]."

10940506

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➶

sparser

"Previous studies have shown that berberine reduced prostaglandin E2 production in vitro (in the oral cancer cell line and KB cells) and in vivo (in carrageenan induced air pouch in rats), moreover berberine inhibited activator protein 1, a key transcriptional factor in inflammation and carcinogenesis [ xref ]."

26862303

---

➶

reach

"In addition, studies showed that the inhibitory effects of berberine were mediated by downregulating cellular c-Jun N-terminal protein kinase (JNK) and NF-kappa B activation (Hayashi et al. 2007), suppressing mitogen-activated protein kinase (MAPK) or MAPK/ERK kinase 1 (MEK)/extracellular signal-regulated kinase (ERK) signalling (Shin et al. 2015; Varghese et al. 2016)."

30963783

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➶

reach

"The electrophoretic mobility shift assay revealed that activator protein 1 (AP-1) binding was decreased in oral cancer cells treated with berberine for 2 h. Further analysis showed that berberine inhibited AP-1 binding directly."

14732220

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➶

reach

"It has been reported that berberine decreases the motility and invasion of non small lung cancer cells by alleviating the activation of c-Fos, c-Jun, and NF-kappaB, and thus inhibits uPA, MMP2 proteins [XREF_BIBR]."

29130448

---

➶

reach

"Previous studies have shown that berberine reduced prostaglandin E2 production in vitro (in the oral cancer cell line and KB cells) and in vivo (in carrageenan induced air pouch in rats), moreover berberine inhibited activator protein 1, a key transcriptional factor in inflammation and carcinogenesis [XREF_BIBR]."

26862303

All-trans-retinoic acid affects JUN

| 7

All-trans-retinoic acid inhibits JUN. 7 / 7

| 7

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➶

reach

"All-trans-retinoic acid (t-RA) inhibited Jun N-terminal kinase (JNK) and, to a lesser extent, extracellular signal regulated kinase activity in normal HBE cells."

9507016

---

➶

reach

"In contrast, ATRA decreased the phosphorylated form of c-Jun in the absence of HCV Core."

29156743

---

➶

reach

"The changes in the levels of the following proteins were confirmed by conventional western immunoblotting : all-trans-retinoic acid increased ELF3, topoisomerase II alpha, RB2 and p130, RIG-G, and EMAPII and decreased MEF2D and cathepsin L. N-(4-Hydroxyphenyl) retinamide up-regulated ELF3, c-Jun, Rb2 and p130, JAK1, p67phox, Grb2, O (6)-methylguanine-DNA methyltransferase, and Ercc-1."

15059897

---

➶

reach

"ATRA is a potent inhibitor of activator protein 1, a transcription factor of the JNK pathway."

18720064

---

➶

reach

"All-trans-retinoic acid inhibits Jun N-terminal kinase dependent signaling pathways."

9507016

---

➶

reach

"ATRA can inhibit the activator protein-1 (AP-1) activity in ATRA sensitive cell lines, but not in ATRA resistant cell line, and the anti-AP-1 activity of ATRA is mediated by its receptor, retinoic acid receptor alpha (RAR alpha)."

11776129

---

➶

reach

"All-trans-retinoic acid inhibits Jun N-terminal kinase by increasing dual-specificity phosphatase activity."

10022884

Acetylsalicylic acid affects NFKB1

| 7

Acetylsalicylic acid inhibits NFKB1. 7 / 7

| 7

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➶

reach

"It is pertinent that the NSAIDs aspirin and salicylate have long been known to also inhibit NFkB signaling by blocking IKKbeta activity [XREF_BIBR], most probably via the same thiol-reactive quinone type of irreversible binding interaction."

25688484

---

➶

reach

"Recent evidence also suggests that platelets may play a more active role in promoting metastatic spread outside of the primary tumour 's microenvironment by active signalling to tumour cells through the TGF-B and NF-Kb pathways resulting in a pro metastatic phenotype that facilitates tumour cell extravasation and metastasis formation [XREF_BIBR], and aspirin is known to inhibit the activation of NF-Kb [XREF_BIBR]."

23589726

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➶

reach

"It has been demonstrated, in human and mouse cell lines, that aspirin and sodium salicylate inhibit the activation of NFKB without af- fecting other transcription factors (Kopp and Ghosh, 1994)."

11545005

---

➶

reach

"Aspirin and sodium salicylate inhibit activation of NF-KB by blocking IkappaB kinase, a key enzyme in NF-kappaB activation."

10402163

---

➶

reach

"It is known that aspirin decreases NFkB activity XREF_BIBR."

21887328

---

➶

reach

"In addition it has been shown that the anti- inflammatory drug aspirin can inhibit the activation of NF-KB [16]."

8941724

---

➶

reach

"Aspirin and salicylates prevent activation of NFkB [XREF_BIBR], making them potentially very useful."

21093723

SP-600125 affects MAPK8

7 |

SP-600125 inhibits MAPK8. 7 / 7

7 |

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➶

tas

No evidence text available

---

➶

tas

No evidence text available

18077363

---

➶

tas

No evidence text available

20146479

---

➶

tas

No evidence text available

15711537

---

➶

tas

No evidence text available

18313304

---

➶

tas

No evidence text available

25415535

---

➶

tas

No evidence text available

21815634

N-tosyl-L-phenylalanyl chloromethyl ketone affects RELA

3 | 4

N-tosyl-L-phenylalanyl chloromethyl ketone inhibits RELA. 7 / 7

3 | 4

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➶

reach

"These results suggest that TPCK inhibits NF-kappaB activation by directly modifying thiol groups on two different targets : Cys 179 of IKKbeta and Cys 38 of p65 and RelA."

19591457

---

➶

reach

"The simultaneous addition of apoA-I and TPCK to the lipid loaded cells induced a small, but significant decrease (p < 0.03) of p65 activation, compared to either one alone."

22056562

---

➶

ctd

No evidence text available

17136479

---

➶

reach

"P65 (Rel A) Ser536 phosphorylation was not affected by the PI3K inhibitors but was dose-dependently attenuated by TPCK."

17136479

---

➶

ctd

No evidence text available

15687330

---

➶

reach

"These results suggest that TPCK inhibits NF-kappaB activation by directly modifying thiol groups on two different targets : Cys 179 of IKKbeta and Cys 38 of p65 and RelA."

19591457

---

➶

ctd

No evidence text available

10467400

N-[3-[[5-cyclopropyl-2-[3-(4-morpholinylmethyl)anilino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide affects TBK1

1 | 6

N-[3-[[5-cyclopropyl-2-[3-(4-morpholinylmethyl)anilino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide inhibits TBK1. 7 / 7

1 | 6

---

➶

reach

"MRT67307 specifically inhibits the IKKepsilon and TBK1 kinases, which are involved in controlling the production of Type1 interferons but also participate in a negative regulatory loop that restricts the extent of activation of the IKK complex [XREF_BIBR] [XREF_BIBR]."

29958295

---

➶

reach

"The IKKepsilon and TBK1 inhibitor MRT67307 inhibits CYLD phosphorylation independent of IKKepsilon and TBK1."

29755980

---

➶

reach

"In addition, the MRC PPU International Centre for Kinase Profiling reported in vitro specificity screens for several inhibitors (http://www.kinase-screen.mrc.ac.uk/kinase-inhibitors), showing that MRT67307 not only inhibits IKKepsilon and TBK1 and the AMPK related kinases MARK, MELK and NUAK, but also Mixed Lineage Kinase (MLK) 1 and MLK3, Janus kinase (JAK) 2, and Ca (2+)/calmodulin-dependent protein kinase kinase beta (CamKKbeta)."

29755980

---

➶

reach

"Taken together, these results indicate that MRT67307 inhibits the phospho (Ser418)-CYLD signal independent of its IKKepsilon and TBK1 inhibitory properties."

29755980

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➶

tas

No evidence text available

---

➶

reach

"For example, MRT67307, which is a new TBK1 inhibitor, derivatized from BX795, suppressed TBK1 activity with much higher specificity (IC 50 = 19nM), so that it did not inhibit other kinases such as JNK or p38 [XREF_BIBR]."

23304064

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➶

reach

"As it was shown previously that MRT67307 can inhibit IKKepsilon and TBK1 at concentrations as low as 1-2 muM, the concentration of 10 muM used may have led to off-target effects."

29755980

LY294002 affects RELA

1 | 1 5

LY294002 inhibits RELA. 7 / 7

1 | 1 5

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➶

reach

"Of note, Gas6 dependent AKT activation was responsible for the nuclear translocation of the anti-apoptotic NF-kappaB subunit p65, since it was detected in nuclear extracts of LX2 cells immediately after rGas6 administration, while PI3K inhibitor LY294002 blocked p65 nuclear upregulation."

25908269

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➶

reach

"Inhibition of PI3K and Akt signaling with LY294002 increased p65 in the nucleus in IL-lbeta+ IFNgamma -stimulated hepatocytes and reversed the dbcAMP induced suppression of nuclear p65 (XREF_FIG)."

20934465

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➶

reach

"In the present study, NF-kappaB (p65) expression was decreased in the EC109 cells treated with metformin or LY294002, but increased in insulin treated EC109 cells pretreated with or without metformin."

29435022

---

➶

reach

"Both LY294002 and parthenolide inhibited EGF induced nuclear accumulation of NF-kappaB p65."

23383347

---

➶

ctd

No evidence text available

21173233

---

➶

reach

"Furthermore, GMPH inhibited nuclear transcription factor kappa-B (NF-kappaB) activation by suppressing the nuclear translocation of NF-kappaB p65, which was markedly reversed by LY294002, an Akt inhibitor."

29666854

---

➶

medscan

"In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor."

12493764

LY294002 affects IFNB1

| 2 5

LY294002 inhibits IFNB1. 7 / 7

| 2 5

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➶

reach

"In turn, LY294002 reduces the activation of IFN-beta reporter genes within murine macrophages, subsequently inhibiting its production [XREF_BIBR]."

25186604

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➶

reach

"As shown in XREF_FIG, while LY294002, an inhibitor of PI3K that is essential for activation of IRF3 by RIG-I and MDA5 XREF_BIBR, dose-dependently inhibited IFN-beta promoter driven luciferase expression (XREF_FIG), RO 90-7501 significantly enhanced the IFN-beta promoter activation by cytoplasmic delivered poly I : C (XREF_FIG)."

23056170

---

➶

reach

"On the other hand, an IRF inhibitor, LY294002, which targets IFN-beta production via IRF3 inhibition, has been shown to sensitize cancer cells to chemotherapy in cervical cancer cells by enhancing mitochondrial JNK signaling."

30186768

---

➶

reach

"Furthermore, IFNbeta production was almost completely inhibited by LY294002."

22208359

---

➶

reach

"Both TNF-alpha and IFN-beta protein concentrations were also reduced significantly by LY294002 treatment, while IFN-beta mRNA level was modestly downregulated."

28623344

---

➶

medscan

"In turn, LY294002 reduces the activation of IFN-β reporter genes within murine macrophages, subsequently inhibiting its production [ ]."

25186604

---

➶

medscan

"The results show that PI3K has a very different role in astrocytes, as LY294002 suppresses all proinflammatory genes, IFNβ, as well as the proinflammatory microRNA, miR-155 (Figure )."

22208359

JNK-IN-8 affects MAPK8

3 | 1 3

JNK-IN-8 inhibits MAPK8. 7 / 7

3 | 1 3

---

➶

tas

No evidence text available

27996267

---

➶

reach

"JNK-IN-8 potently inhibits JNK1, 2 and 3 enzymatic activity with IC 50 s of 4.7 nM, 18.7 nM and 1.0 nM respectively and inhibits a c-Jun, a direct phosphorylation substrate of JNK, with an EC 50 of 486 nM in Hela cell."

23438744

---

➶

reach

"Importantly, our data strongly suggest that concomitant inhibition of JNK1 by JNK-IN-8 in the context of JNK2 C116S expression (and intact JNK2 signaling) contributes to tumor progression."

31063355

---

➶

eidos

"Importantly , our data strongly suggest that concomitant inhibition of JNK1 by JNK-IN-8 in the context of JNK2C116S expression ( and intact JNK2 signaling ) contributes to tumor progression ."

31063355

---

➶

reach

"The result that JNK1 inhibition by JNK-IN-8 is important for synergy with lapatinib is not surprising considering that JNK-IN-8 was shown to have greater activity toward purified, recombinant JNK1 in vitro [XREF_BIBR]."

29285221

---

➶

tas

No evidence text available

25415535

---

➶

tas

No evidence text available

22621397

His-Ser affects CASP1

| 7

His-Ser inhibits CASP1. 7 / 7

| 7

---

➶

reach

"HS inhibits 5-FU-mediated caspase-1 activation in vitro and in vivo without affecting its cytotoxicity on MDSCs."

32385145

---

➶

reach

"We show here that HS is able to inhibit caspase-1 activation in MDSCs and tumor growth and conversely that HSP70 deficiency increases caspase-1 activation in MDSCs and accelerates tumor growth in a murine preclinical model."

32385145

---

➶

reach

"Altogether, our results show that HS is able to inhibit 5-FU-mediated caspase-1 activation without affecting 5-FU MDSC killing."

32385145

---

➶

reach

"However, a HS leading to HSP70 expression inhibited the activation of caspase-1 and the release of active caspase-1 and mature IL-1beta (XREF_FIG)."

32385145

---

➶

reach

"Because HS inhibits caspase-1 activation in MDSCs, we investigated its effects on tumor growth, in mice subcutaneously injected with EL4 tumor cells."

32385145

---

➶

reach

"HS inhibits caspase-1 activation in MDSCs in vitro and in vivo."

32385145

---

➶

reach

"However, HS inhibited 5-FU-mediated caspase-1 activation (XREF_FIG)."

32385145

Arg-Val affects IFNB1

| 7

Arg-Val inhibits IFNB1. 7 / 7

| 7

---

➶

reach

"Ex vivo studies in airway epithelial cells found that RV-induced IFN-β and IFN-λ responses were impaired in subjects with asthma, leading to increased viral replication and shedding and exaggerated secondary responses [85, 86]."

27871304

---

➶

reach

"Ex vivo studies in airway epithelial cells found that RV induced IFN-beta and IFN-lambda responses were impaired in subjects with asthma, leading to increased viral replication and shedding and exaggerated secondary responses [XREF_BIBR, XREF_BIBR]."

27871304

---

➶

reach

"Cultured primary BECs from adults with allergic asthma exhibit lower levels of RV induced IFNbeta (a type I IFN), lower levels of virus induced apoptosis and higher RV loads than cells from control adults 127."

22669219

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➶

reach

"Only a previous infection with RV was able to reduce by 60% the IFN-β mRNA levels produced after polyI:C transfection, although differences were not statistically significant (Fig 6A)."

25837699

---

➶

reach

"Such reduced infectivity of basolaterally administered RV correlated with marked attenuation of IRF7, STAT1, and PKR activation and induced secretion of IFN-beta and IL-8 (XREF_FIG)."

20664578

---

➶

reach

"Similarly, asthma was associated with lower fold increases in RV induced IFNB1 mRNA (p = 0.01) and IL28 mRNA (p = 0.009)."

24219422

---

➶

reach

"The deficient IFN-beta observed was not related to GC use, as GC treated and GC naive asthmatic individuals exhibited similar levels of reduced RV induced IFN-beta."

23212197

(-)-epigallocatechin 3-gallate affects TRAF6

| 3 4

(-)-epigallocatechin 3-gallate inhibits TRAF6. 7 / 7

| 3 4

---

➶

medscan

"Among these amino acids, mutation of Gln54, Asp57, ILe72 in TRAF6 could destroy Epigallocatechin-3-gallate bound to TRAF6, furthermore, our results demonstrated that Epigallocatechin-3-gallate significantly attenuates interaction between TRAF6 and UBC13(E2) and suppresses TRAF6 E3 ubiquitin ligase activity in vivo and in vitro. 44999997="E2" 44999998="D57" 44999999="Q54"}"

27791197

---

➶

medscan

"Next, our results demonstrated that epigallocatechin-3-gallate suppresses the E3 ubiquitin ligase activity of TRAF6 in vitro and in vivo."

27791197

---

➶

reach

"Next, our results demonstrated that EGCG suppresses the E3 ubiquitin ligase activity of TRAF6 in vitro and in vivo."

27791197

---

➶

reach

"EGCG inhibited the activation of NF-kappaB and the upregulation of TLR 2, 4 and 9 as well as their adaptors MyD88 and TRAF6 in the lungs following PQ challenge."

27890776

---

➶

reach

"EGCG impairs the E3 ubiquitin ligase activity of TRAF6."

27791197

---

➶

medscan

"Epigallocatechin-3-gallate suppresses melanoma cell growth and metastasis by targeting TRAF6 activity"

27791197

---

➶

reach

"We observed that EGCG decreased the triglyceride (TG) concentration in rat livers and suppressed TLR4, TRAF6, IKKbeta, p-IKKbeta, p-NF-kappaB, and TNF-alpha levels compared with those in the HFD group, whereas PI3K, AKT, IRS-1, and IRS-2 indicators were improved."

32281563

Melatonin affects RELA

| 7

Melatonin inhibits RELA. 6 / 6

| 6

---

➶

reach

"Our results showed that melatonin treatment inhibited NF-kappaB p65 activation."

27666165

---

➶

reach

"Herein, we showed that melatonin inhibited the activation of p65 in the testes of the stressed mice as well as in H 2 O 2 -treated testicular cells."

28851995

---

➶

reach

"Further analysis demonstrated that melatonin significantly reduced p65 activation and the release of inflammatory factors."

25059226

---

➶

reach

"To determine whether melatonin inhibits NF-kappaB and p65 signaling in thyroid cancer, the total and nuclear portions of 8505c and TPC-1 cells were isolated after treatment with different concentrations of melatonin."

29525603

---

➶

reach

"3.3 Melatonin inhibits NF-kappaB and p65 signaling in thyroid cancer."

29525603

---

➶

reach

"In addition, melatonin decreased TNBS induced up-regulation of TLR4, MyD88, and NF-kappaB p65, and increased down-regulation of I-kappaB proteins."

30143913

Melatonin inhibits phosphorylated RELA. 1 / 1

| 1

---

➶

reach

"In addition, melatonin did not reduce the phosphorylated NFkappaB p65, AP-1 and SP-1 induced by TPA."

26980735

Hemin affects EIF2AK1

| 1 6

Hemin inhibits EIF2AK1. 6 / 6

| 6

---

➶

reach

"We conclude that disulfide formation by hemin provides a likely mechanism by which hemin prevents the activation and inhibits the activity of HRI."

2722851

---

➶

reach

"The results are as follows : (i) Both hemin and p67 inhibited HRI (heme regulated protein synthesis inhibitor) and dsI (double stranded RNA activated protein synthesis inhibitor) catalyzed phosphorylation of eIF-2 alpha-subunit in vitro."

7911326

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➶

reach

"It was interesting to observe that hemin downregulated HRI promoter activity in a dose dependent manner."

16500424

---

➶

reach

"Contrary to this, hemin, a suppressor of HRI kinase activity, downregulated HRI promoter activity and stimulated hemoglobin synthesis."

16500424

---

➶

reach

"Most recently, Hsp70 has been shown to prevent the activation of HRI in hems deficiency by reducing the optimal concentration of hemin required to suppress HRI activatian2s."

7709427

---

➶

reach

"Delayed addition of hemin to shut-off lysates inhibits the eIF-2alpha kinase activity of HRI and restores protein synthesis; under those conditions, the endogenous phosphatase of the lysate dephosphorylates phosphorylated eIF-2alpha and restores eIF-2B activity."

8619603

Hemin inhibits EIF2AK1. 1 / 1

| 1

---

➶

medscan

"Likewise, addition of hemin, which inhibits EIF2AK1/HRI and which suppressed EIF2A phosphorylation in cells exposed to oxidative stress, did not affect EIF2A phosphorylation in cells treated with CCT020312 ( )."

22253692

Antagonist affects ITCH

| 7

Antagonist inhibits ITCH. 6 / 6

| 6

---

➶

sparser

"An intradermal injection of histamine elicits itch, which is inhibited by a histamine H 1 receptor antagonist (Hägermark et al., 1978) ."

11011046

---

➶

sparser

"Furthermore, previous studies have shown that opioid μ antagonists inhibit the substance P–induced itch in mice 25 and alleviate the itch in patients with AD and cholestatic pruritus."

24641902

---

➶

sparser

"It has been known for decades that analgesia obtained with mu opioids induces itch, most probably via reduction of inhibition of pain fibers, whereas mu antagonists, such as naltrexone, inhibit itch."

20948846

---

➶

sparser

"It is well known that histamine H(1) receptor antagonists inhibit the itch and rhinorhea, but do not block the allergic nasal congestion."

12359275

---

➶

sparser

"Indeed, it has now been shown that a selective H₄R antagonist can inhibit histamine-induced itch in humans."

25861785

---

➶

sparser

"In female BalbC mice, H2R agonist (dimaprit) failed to cause scratching and H2R antagonist (cimetidine) could not inhibit histamine-induced itch in mice ( xref )."

21841076

Antagonist inhibits ITCH. 1 / 1

| 1

---

➶

sparser

"Inhibition of itch in vivo by NPR1 antagonists."

31292265

U0126 affects FOS

| 3 4

U0126 inhibits FOS. 6 / 6

| 2 4

---

➶

reach

"EGF increased p-ERK1/2, c-Fos, c-Jun, and p-c-Jun levels, which were inhibited by U0126."

19937979

---

➶

medscan

"U0126 inhibits c-Fos signaling pathway, and SP600125 inhibits c-Jun signaling pathway, in JFH1 and in H77s cells. 10 µM c-Fos inhibitor (U0126) or 20 µM c-Jun inhibitor (SP600125) was added to JFH1 and H77s cell cultures."

23844083

---

➶

medscan

"U0126, a MEK inhibitor, inhibited EGF-induced increases in c-Fos, p-ERK, and TRPM6 levels."

21073857

---

➶

reach

"The use of U0126, an ERK inhibitor, effectively suppressed HGF mediated induction of Egr1, c-Fos, GDNF, and Lif as well as SC migration."

29844434

---

➶

reach

"Zta protein production was stimulated by TPA at 6h and maintained at a high level until 24h, ERK phosphorylation was induced by TPA from 1h to 12h, c-Jun phosphorylation was induced by TPA at 1h and increased in a time dependent manner, whereas c-Fos phosphorylation was up-regulated by TPA from 3h to 12h, however, TPA induced production of Zta and phosphorylation of ERK, c-Jun, and c-Fos were repressed by U0126 (XREF_FIG)."

27708396

---

➶

reach

"U0126 inhibits de novo synthesis of c-Fos after T cell stimulation in a dose dependent manner."

22969764

U0126 inhibits FOS. 1 / 1

| 1

---

➶

medscan

"We found that induction of both c-fos and c-jun by arsenite can be substantially inhibited by the MEK- selective inhibitor U0126, suggesting that the ERK pathway is critically involved in their up-regulation."

12547826

SB220025 affects MAPK14

4 3 |

SB220025 inhibits MAPK14. 4 / 4

4 |

---

➶

tas

No evidence text available

20188577

---

➶

tas

No evidence text available

11597418

---

➶

tas

No evidence text available

11354358

---

➶

tas

No evidence text available

17948975

SB220025 inhibits MAPK14. 3 / 3

3 |

---

➶

drugbank

No evidence text available

17139284

---

➶

drugbank

No evidence text available

10592235

---

➶

drugbank

No evidence text available

17016423

Tranilast affects NLRP3

| 6

Tranilast inhibits NLRP3. 6 / 6

| 6

---

➶

reach

"Unlike the CY-09 identified by the same group, Tranilast inhibits NLRP3 inflammasome activation via an ATPase independent manner, by blocking direct NLRP3-NLRP3 interaction 109."

30755589

---

➶

reach

"A single-arm prospective cohort (phase II) study designed to observe the efficacy and safety of tranilast (a small molecule inhibitor of the NLRP3 inflammasome) in CAPS patients."

32655539

---

➶

reach

"Tranilast markedly suppressed NLRP3 inflammasome activation in low-density lipoprotein receptor- and apolipoprotein E deficient macrophages."

32476536

---

➶

reach

"Tranilast is an antagonist of NLRP3 that inhibits the inflammasome pathway."

32423024

---

➶

reach

"Like the three specific inhibitors mentioned above, Tranilast does not interfere with the upstream signaling pathways of NLRP3 inflammasome, including NLRP3 and pro-IL-1beta expression, K + efflux, mitochondrial damage, ROS production, and chloride efflux, and can not prevent the newly identified NLRP3 inflammasome component NEK7 from interacting with NLRP3 109."

30755589

---

➶

reach

"As a safe small-compound drug employed frequently in clinic, tranilast (TR) is newly reported to block the activation of NLRP3 inflammasome in macrophage."

32754591

Thiostrepton affects RELA

| 6

Thiostrepton inhibits RELA. 6 / 6

| 6

---

➶

reach

"Thiostrepton specifically inhibits RelA activation by A-site deacylated tRNA while not affecting RelA activation by the ribosome itself."

28115345

---

➶

reach

"We show that in a biochemical system from purified E. coli components, the antibiotic thiostrepton efficiently inhibits RelA activation by the A-site tRNA."

28115345

---

➶

reach

"We have shown that thiostrepton specifically inhibits RelA activation by the A-site tRNA and has no effect on RelA activated by 70S alone, whereas EF-G is inhibited equally efficiently regardless of the presence or absence of A-site tRNA (XREF_FIG)."

28115345

---

➶

reach

"Next, we tested whether the dependence of RelA inhibition by thiostrepton on the presence of A-site deacylated tRNA, the ultimate inducer of the enzyme 's enzymatic activity and a key factor in promoting RelA binding to the ribosome, is specific to this antibiotic."

28115345

---

➶

reach

"The cyclic peptide thiostrepton is an efficient inhibitor of both translational GTPases, targeting initiation factor IF2 and elongation factors EF-Tu and EF-G on the ribosome, and E. coli RelA."

28115345

---

➶

reach

"A-site tRNA dependent inhibition of RelA by thiostrepton."

28115345

Tamoxifen affects MAP3K7

| 6

Tamoxifen inhibits MAP3K7. 6 / 6

| 6

---

➶

reach

"Tamoxifen dependent conditional depletion of TAK1 in microglial cells was induced in Cx3cr1 creER -Tak1 fl/fl mice."

32382778

---

➶

reach

"In ER-TAK1 fl/fl mice, tamoxifen application on local skin could induce TAK1 deletion in various cell types including stromal cells, particularly cutaneous DC that are considered to play a central role for initiating response to haptens."

21552285

---

➶

reach

"Map3k7 (f/f) Cre-ER (TM) mice (in which tamoxifen induces global TAK1 deletion) and control Map3k7 (f/f) mice were given tamoxifen at the time of unilateral ureteric obstruction (UUO) and then killed 2, 4, or 5 days later."

21367917

---

➶

reach

"Although the role of TRAF6 in the survival of adipocytes has not been documented, a recent study has shown that tamoxifen inducible inactivation of TAK1 promotes apoptosis in adipocytes [XREF_BIBR]."

29348847

---

➶

reach

"Similar to these findings, Sassmann-Schweda et al have recently reported that tamoxifen inducible inactivation of TAK1 causes adipocyte cell death through apoptosis [XREF_BIBR]."

29348847

---

➶

reach

"Tak1 gene deletion was induced by 5 consecutive day treatment of 0.5-1 mg/mouse/day tamoxifen."

20959492

Sulforaphane affects RELA

| 6

Sulforaphane inhibits RELA. 6 / 6

| 6

---

➶

reach

"Furthermore, SFN treatment suppressed nuclear localization of p65."

20688330

---

➶

reach

"To determine whether SFN suppresses MAPKs and p65 activation to exert its effects on the pro inflammatory markers, we measured the phosphorylation of MAPKs and NF-kappaB p65 proteins."

29391237

---

➶

reach

"As shown in Fig. 5, SFN reduced the nuclear localization of p65 induced by TNF-alpha."

20688330

---

➶

reach

"In addition, SFN has been shown to prevent the degradation of IkappaB-alpha and nuclear localization of p65 in bovine aortic endothelial cells, presumably via reduction of intracellular glutathione level [31]."

20688330

---

➶

reach

"To study whether SFN was also able to inhibit nuclear localization of p65 after TNF-alpha treatment, immunocytochemical staining of p65 was performed."

20688330

---

➶

reach

"The western blotting results showed that SFN visibly impaired p65 production, whereas SFN enhanced p50 secretion in moDCs (XREF_FIG)."

25793534

Staurosporine affects JAK1

5 | 1

Staurosporine inhibits JAK1. 6 / 6

5 | 1

---

➶

tas

No evidence text available

18183025

---

➶

reach

"Staurosporine was used as a positive control and inhibited the activity of both Jak1 and Jak2 kinase with an IC 50 of < 1.0 nM."

21226522

---

➶

tas

No evidence text available

27288183

---

➶

tas

No evidence text available

27137359

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

22037378

Sodium(1+) affects NLRP3

| 6

Sodium(1+) inhibits NLRP3. 6 / 6

| 6

---

➶

reach

"Sodium Butyrate and beta-Hydroxybutyric Acid Topical Treatment Inhibits Activation of NLRP3 Inflammasome in Alkali Injured Corneas."

28273882

---

➶

reach

"It also ameliorates dextran sulfate sodium induced colitis in caspase-1 -/- mice by inhibiting the activation of NLRP3 inflammasomes and the subsequent secretion of IL-1beta."

29491837

---

➶

reach

"[Sodium Ferulate Attenuates Oxidative Stressvia Suppressing NALP3 Inflammasome and ERK Signal Pathway]."

28598074

---

➶

reach

"For example, Wang et al. reported that sodium butyrate treatment can efficiently inhibit Nlrp3 inflammasome activation and thereby inhibits obesity induced inflammation, indicating that NaB might be a potential anti-inflammatory agent for obesity in db/db mice XREF_BIBR."

29475132

---

➶

reach

"Sodium butyrate has a similar chemical structure to HBA and also has been reported to inhibit the NLRP3 pathway [XREF_BIBR]."

28273882

---

➶

reach

"Conclusions : Sodium butyrate can inhibit the activation of NLRP3 inflammasome and decrease the production of IL-1beta and IL-18 in intestinal mucosa of severe scald mice, which protects the intestinal barrier function by alleviating the alteration of tight junction protein expression and localization."

32023718

Sirolimus affects CASP1

| 6

Sirolimus inhibits CASP1. 6 / 6

| 6

---

➶

reach

"Rapamycin treatment significantly suppressed IL-1beta secretion and caspase-1 cleavage in a dose dependent manner."

28489580

---

➶

reach

"The 45 kD or 20 kD caspase-1 was increased by I/R or CsA, respectively, and decreased by rapamycin (P < 0.05)."

16221205

---

➶

reach

"Similarly, rapamycin, a selective mTORC1 inhibitor, suppressed caspase-1 activation in wild type BMDM in response to LPS and ATP, compared to vehicle control (XREF_FIG)."

26119735

---

➶

reach

"In contrast to the finding with 3-MA, rapamycin inhibited PrP106-126-induced activation of caspase-1 (p45), and microglial cells produced decreased level of caspase-1 p10."

29720937

---

➶

reach

"Similarly, rapamycin, a selective mTORC1 inhibitor (Benjamin et al., 2011), suppressed caspase-1 activation in wild-type BMDMs in response to LPS and ATP, compared to vehicle control."

26119735

---

➶

reach

"Caspase-1 remained activated in GMs after treatment with rapamycin, although to a lesser extent than with LPS and ATP, while rapamycin inhibited caspase-1 activation in control macrophages."

26486234

Simvastatin affects NLRP3

| 6

Simvastatin inhibits NLRP3. 6 / 6

| 6

---

➶

reach

"In summary, the present study demonstrated that simvastatin inhibited NLRP3 inflammasome in RAECs through inhibiting NADPH oxidase dependent O 2 - production."

29207644

---

➶

reach

"However, simvastatin combined with MCC950 or NLRP3 siRNA showed no additive effects on caspase-1 activity and the release of IL-1beta, which confirmed that simvastatin indeed inhibited the activation of NLRP3 inflammasome induced by high glucose."

29207644

---

➶

reach

"Collectively, these results demonstrate that the statin activation of PXR inhibits the activation of NLRP3 inflammasome in response to atherogenic stimuli such as ox-LDL and TNF alpha in ECs, providing a new mechanism for the cardiovascular benefit of statins."

28546421

---

➶

reach

"The inhibitory effects of NADPH oxidase inhibitor, apocynin (APO) on the oligomerization of NLRP3 and ASC induced by high glucose were also observed, suggesting that simvastatin inhibited the NLRP3 inflammasome activation via NADPH oxidase dependent ROS production in RAECs."

29207644

---

➶

reach

"XREF_BIBR XREF_BIBR On the contrary, other research groups describe statin inhibits the formation of NLRP3 in immune and vascular cells in various inflammatory and oxidative conditions."

30334382

---

➶

reach

"Our results indicate that simvastatin inhibited the NLRP3 inflammasome pathway and thereby decreased the secretion of HMGB1 from vascular endothelial cells."

29207644

Simvastatin affects IFNB1

| 6

Simvastatin inhibits IFNB1. 6 / 6

| 6

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➶

reach

"52 In conclusion, high-dose statin add-on therapy impaired the ability of interferon-beta to activate STAT1 and, in turn, to induce IRF-1, serum type 1 interferons, and MxA and viperin proteins."

22801747

---

➶

reach

"Independent of mevalonate and NF-kappaB, previously acknowledged anti-inflammatory mechanisms of pleiotropic statins, simvastatin selectively inhibited dsRNA induced IRF3 activation and production of TSLP and IFN-beta in COPD epithelium."

22881993

---

➶

reach

"These results demonstrate that high-dose statin add-on therapy blocks interferon-beta responses in vivo."

22801747

---

➶

reach

"These data indicate that high-dose statin add-on therapy inhibits interferon-beta activity in most patients, whereas moderate doses have lesser inhibitory effects."

22801747

---

➶

reach

"High-dose add-on statin therapy significantly blocked interferon-beta function, with less P-Y-STAT1 transcription factor activation, and reduced myxovirus resistance 1 protein and viperin protein production."

22801747

---

➶

reach

"To determine whether statin add-on therapy impairs interferon-beta therapy induction of endogenous serum interferon-beta activity, we measured serum type 1 interferon activity and interferon induced proteins in 14 interferon-beta-treated RRMS patients under 4 different conditions (XREF_FIG)."

22801747

Silibinin affects NLRP3

| 6

Silibinin inhibits NLRP3. 6 / 6

| 6

---

➶

reach

"In our study, we found that silybin inhibited endoplasmic reticulum stress and NLRP3 inflammasome activation in the livers of HFD fed mice and in cultured hepatocytes."

28970254

---

➶

reach

"Silybin inhibits the activation of the NLRP3 inflammasome in THP-1 cells by reducing the production of intracellular ROS."

28350048

---

➶

reach

"Silibinin Downregulates the NF-kappaB Pathway and NLRP1 and NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia."

31010153

---

➶

reach

"Therapeutic effects of silibinin on LPS induced acute lung injury by inhibiting NLRP3 and NF-kappaB signaling pathways."

28483599

---

➶

reach

"In addition, silybin inhibited the approach of calreticulin and translocase of outer membrane 20 (Tom20), prevented assembly of the NLRP3 inflammasome complex, and suppressed the accumulation of acetylated alpha-tubulin in the perinuclear region."

28970254

---

➶

reach

"Silymarin prevents NLRP3 inflammasome activation and protects against intracerebral hemorrhage."

28651232

Serotonin affects FOS

| 6

Serotonin inhibits FOS. 6 / 6

| 6

---

➶

reach

"Pre-synaptic 5-HT 1A receptors in the raphe nuclei when activated by 8-OH-DPAT attenuated the c-Fos increase induced by immobilization stress (Rioja et al., 2006)."

27436722

---

➶

reach

"Furthermore, serotonin depletion also prevented the TBI induced bilateral increase in c-Fos positive cells within the Rexed laminae I and II of the dorsal horns."

31185197

---

➶

reach

"Increased serotonin levels decreased c-fos labeling more in a non socially relevant context than during interaction with a male."

27657308

---

➶

reach

"The role of 5-HT 2C receptors in these effects would be only partial because selective 5-HT 2C antagonists did not fully block the induction of c-Fos induced by non selective 5-HT 2C agonists (Navailles et al., unpublished observation)."

23997751

---

➶

reach

"Selective serotonin reuptake inhibitors induce c-fos activation in the central nucleus of the amygdala, bed nucleus of the stria terminalis, and lateral parabrachial nucleus (Veening et al., 1998)."

12445576

---

➶

reach

"XREF_BIBR 5-HT 1F agonists have been shown to decrease c-fos activity within the trigeminal nucleus."

30323656

Quercetin affects RELA

1 | 5

Quercetin inhibits RELA. 6 / 6

1 | 5

---

➶

ctd

No evidence text available

18852136

---

➶

reach

"Quercetin decreased Rel-A and p65, without modifying upstream signalling."

18404532

---

➶

reach

"Quercetin decreased Rel-A and p65, without modifying upstream signalling."

18404532

---

➶

reach

"Compared with the RE control group, esophageal mucosal injury was improved and the expressions of NF-kappaBp65 and IL-8 were significantly decreased in the RE group treated with omeprazole or quercetin (P < 0.05)."

25858763

---

➶

reach

"Quercetin (25 muM) and galangin (25 muM) markedly inhibited the LPS induced nuclear trans-location of NF-kappaB and p65 (XREF_FIG)."

29207037

---

➶

reach

"Quercetin could inhibit the activation of TLR4 and NF-kappaB p65."

27279714

Quercetin affects JUN

1 | 1 4

Quercetin inhibits JUN. 6 / 6

1 | 1 4

---

➶

reach

"Bioflavonoid quercetin inhibits hydrogen peroxide (H2O2)-induced apoptosis via intervention in the activator protein 1 (AP-1)-mediated apoptotic pathway."

10972672

---

➶

reach

"Suppression of the androgen receptor function by quercetin through protein protein interactions of Sp1, c-Jun, and the androgen receptor in human prostate cancer cells."

20148354

---

➶

reach

"Western blotting showed that siRNA mediated inhibition of PPAR-gamma transcription led to an increase in AP-1 (c-fos, c-jun) protein expression in H9C2 cells, indicating that quercetin, at least in part, deregulates c-fos and c-jun via the PPAR-gamma signaling pathway."

24039778

---

➶

ctd

No evidence text available

20804812

---

➶

medscan

"The in vitro streptavidin-agarose pulldown assay and in vivo chromatin immunoprecipitation assay showed that quercetin considerably inhibited the binding of the transactivators CREB2, C-Jun, C/EBPβ and NF-κB and blocked the recruitment of the coactivator p300 to COX-2 promoter."

21857970

---

➶

reach

"XREF_BIBR In a human endothelial cell line ECV304, quercetin treatment downregulated activator protein 1 (AP-1) and ICAM-1 messenger RNA (mRNA) levels, but had no effect on nuclear factor-kappaB (NF-kappaB) activation."

25387248

Pyridoxamine affects NLRP3

| 6

Pyridoxamine inhibits NLRP3. 6 / 6

| 6

---

➶

reach

"In addition, PM can effectively inhibit the activation of NLRP3 inflammasome and decrease the release of proinflammatory cytokines."

32410849

---

➶

reach

"To assess whether PM could inhibit NLRP3 inflammasome activation, we assessed the effect of PM on NLRP3 inflammasome and IL-1beta secretion."

32410849

---

➶

reach

"NLRP3 Inflammasome Activation Was Inhibited by PM."

32410849

---

➶

reach

"Also, RES treatment abolished PM induced lung inflammation and fibrosis, and inhibited autophagic process and NLRP3 inflammasome activation."

31295660

---

➶

reach

"PM improved the inflammation, inhibited the activation of NLRP3 inflammasome, and reduced the release of IL-1beta."

32410849

---

➶

reach

"Mechanistically, PM 2.5 exposure suppressed the NLRP3 inflammasome activation and the AHR-TIPARP signaling pathway, by which compromised the anti-influenza immunity."

32717666

Phenethyl caffeate affects PYCARD

| 6

Phenethyl caffeate inhibits PYCARD. 6 / 6

| 6

---

➶

reach

"Moreover, CAPE significantly inhibited the formation of ASC dimers and reduced the abundance of NLRP3 inflammasome complexes in a dose dependent manner (XREF_FIG)."

32435622

---

➶

reach

"CAPE did not affect the mRNA levels of ASC, suggesting that CAPE did not inhibit the synthesis of ASC (XREF_SUPPLEMENTARY)."

27934918

---

➶

reach

"Addition of CAPE attenuated precipitation of ASC with BT-CA, showing that CAPE prevented the binding of BT-CA to ASC (XREF_FIG)."

27934918

---

➶

reach

"These results suggest that CAPE suppresses the activation of the NLRP3 inflammasome by directly binding ASC, blocking the association of NLRP3 and ASC."

27934918

---

➶

reach

"Co-immunoprecipitation study showed that CAPE prevented MSU induced association of NLRP3 and ASC in BMDMs (XREF_FIG)."

27934918

---

➶

reach

"Consistently with the results with XREF_FIG, addition of CAPE abolished the precipitation of ASC with BT-CA in 293T cell lysates (XREF_FIG)."

27934918

Momelotinib affects JAK1

1 2 | 3

Momelotinib inhibits JAK1. 6 / 6

1 2 | 3

---

➶

tas

No evidence text available

| DOI

---

➶

signor

No evidence text available

Other

---

➶

tas

No evidence text available

19762238

---

➶

reach

"28 Finally, momelotinib (also known as CYT-387) inhibits both JAK1 (IC 50 11 nm) and JAK2 (IC 50 18 nm), rather than JAK3 (IC 50 0.16 muM), although off-target effects (serine/threonine kinase IKBKE) have been described."

32676568

---

➶

reach

"Momelotinib is a potent inhibitor of JAK1 and JAK2 that demonstrated efficacy in patients with primary and secondary myelofibrosis."

28622623

---

➶

reach

"Momelotinib is a potent inhibitor of JAK1 and JAK2."

32394008

Mevalonic acid affects NFKBIA

| 6

Mevalonic acid inhibits NFKBIA. 6 / 6

| 6

---

➶

reach

"The requirement for infectious virions, together with the ability of MVA to induce IkappaBalpha degradation in the presence of cycloheximide, implicate viral early RNAs as prime candidates for stimulating NF-kappaB activation."

19596385

---

➶

reach

"One indication that MVA may have a greater capacity to initiate NF-kappaB activation than some of the other orthopoxviruses is that MVA induces IkappaBalpha degradation even in the presence of cycloheximide, whereas cowpox virus induces little if any IkappaBalpha degradation under similar conditions."

19596385

---

➶

reach

"This result shows that an early event in the MVA infection cycle, preceding viral DNA replication and late gene expression, is sufficient to trigger IkappaBalpha degradation."

19596385

---

➶

reach

"The nature of the stimuli responsible for MVA mediated activation of IkappaBalpha degradation has yet to be determined."

19596385

---

➶

reach

"We and others have demonstrated that expression of the VAC K1L gene is sufficient to suppress MVA induced IkappaBalpha degradation and subsequent activation of NF-kappaB."

22534090

---

➶

reach

"In addition, we have shown that the cowpox virus CP77 gene, which can functionally substitute for the K1L gene to permit replication of MVA in RK13 cells, also can suppress MVA induced degradation of IkappaBalpha."

19596385

Mesalamine affects RELA

| 2 4

Mesalamine inhibits RELA. 6 / 6

| 2 4

---

➶

sparser

"The calycosin (50 mg/kg) and 5-ASA inhibited the phosphorylation of IKKα/β, IκBα and p65 to attenuate the inflammation, which was consistent with the suppression of mRNA expressions ( xref )."

29085602

---

➶

reach

"We further investigated whether siPAK1 or 5-ASA reduced p65 at the transcriptional level."

26036343

---

➶

reach

"Moreover, mesalamine can also inhibit phospohorylation of the p65 subunit of NF-kappaB, a post-translational modification that is essential for its transcriptional activity."

19707368

---

➶

reach

"Here we demonstrate that 5-ASA induced degradation of p65 protein (XREF_FIG C) indicative of PPARgamma 's E3 ubiquitin ligase activity."

26036343

---

➶

reach

"Nevertheless, NF-kappaB p65 and NF-kappaB p65 mRNA expression was significantly reduced in DSS induced UC rats treated with QCWZD and mesalazine (P < 0.05, resp., Figures XREF_FIG and XREF_FIG)."

27413386

---

➶

sparser

"The calycosin (50 mg/kg) and 5-ASA inhibited the phosphorylation of IKKα/β, IκBα and p65 to attenuate the inflammation, which was consistent with the suppression of mRNA expressions ( xref )."

29085602

Magnesium atom affects RELA

| 6

Magnesium atom inhibits RELA. 6 / 6

| 6

---

➶

reach

"Mg supplementation protected the ZO-1 cell-cell tight junction and inhibited the p65 activation induced by LPS (XREF_FIG E)."

32045781

---

➶

reach

"IF staining and WB consistently showed that the NF-κB p65 nuclear translocation was decreased by Mg treatment at both LPS and RANKL induced conditions after 30 min treatment (Fig. 2D)."

32045781

---

➶

reach

"High [Mg (2+)] (o) (i.e. 4.8 mM) downregulated p50 and p65."

12697280

---

➶

reach

"MG induced activation of NF-kappaB p65 was inhibited by NAC."

15759051

---

➶

reach

"IF staining and WB consistently showed that the NF-kappaB p65 nuclear translocation was decreased by Mg treatment at both LPS and RANKL induced conditions after 30min treatment (XREF_FIG D)."

32045781

---

➶

reach

"Mg supplementation protected the ZO-1 cell-cell tight junction and inhibited the p65 activation induced by LPS (Fig. 7E)."

32045781

Lipopolysaccharide affects TRAF3

| 6

Lipopolysaccharide inhibits TRAF3. 6 / 6

| 6

---

➶

reach

"The TLR4 ligand LPS stimulates TRAF3 degradation in both the Raw264.7 macrophage cell line and the CNS-resident macrophages, which likely serves as a mechanism to override the inhibitory function of TRAF3 XREF_BIBR, XREF_BIBR."

27012466

---

➶

reach

"Treatment of cells with the proteasome inhibitor MG132 inhibited the LPS stimulated degradation of TRAF3 in wild-type and Usp25 -/- BMDMs (XREF_FIG)."

23674823

---

➶

reach

"We found that LPS stimulated rapid degradation of Traf3 in wild-type microglia (XREF_FIG), although such a signaling event was much less prominent in BM derived macrophages (data not shown)."

23603814

---

➶

reach

"It has been shown that the TLR4 ligand LPS stimulates TRAF3 degradation in a macrophage cell line (Raw264.7) and primary microglia, although this signaling event is weak in bone marrow derived macrophages."

26085207

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➶

reach

"Congruently, TRAF6 ablation inhibited LPS induced TRAF3 degradation (XREF_FIG)."

19898473

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➶

reach

"The LPS stimulated Traf3 degradation was blocked in the Peli1 deficient microglia (XREF_FIG), which could be rescued by reconstitution with exogenous Peli1 (XREF_SUPPLEMENTARY)."

23603814

Lipopolysaccharide affects FOS

| 6

Lipopolysaccharide inhibits FOS. 6 / 6

| 6

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➶

reach

"Of particular interest was the observation that LPS, administered in the absence or presence of MDP, decreased the number of c-Fos positive cells in the dentate gyrus of the hippocampus, which has been associated with a decrease of exploratory behavior following treatment with LPS."

25218901

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➶

reach

"Our results indicate that KPG pretreatment caused a concentration dependent attenuation of the expression of LPS induced c-Fos, but not of c-Jun."

29470957

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➶

reach

"Blockade of both B1R and B2R reduced the LPS induced c-Fos immunoreactivity in the hypothalamus."

26468906

---

➶

reach

"Potential down-regulation of salivary gland AQP5 by LPS via cross coupling of NF-kappaB and p-c-Jun and c-Fos."

20522648

---

➶

reach

"Another cAMP mediated suppressive mechanism of LPS induced pro inflammatory cytokine production involves the transcription factor c-Fos."

25632271

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➶

reach

"At 31 or 40 h after PW (i.e., 3 or 12 h after treatment, respectively), LPS decreased% ER alpha and c-Fos in the ARC and the mPOA, but there was no change in the VMN compared to that in controls."

25320149

Lactate affects DDX58

| 3 1 2

Lactate inhibits DDX58. 6 / 6

| 3 1 2

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➶

sparser

"In order to unravel the underlying mechanism by which lactate inhibits RIG-I-MAVS induced RLR activation, we explored whether lactate impacts the mitochondria localization of MAVS by binding to its TM domain, ( xref )."

31155231

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➶

reach

"Lactate and hexokinase have also recently been found to inhibit RIG-I and MDA5 by interacting with MAVS, which may be significant in explaining the interplay between metabolism and immune signaling as glycolysis was found to be greatly decreased upon RLR signaling (329)."

31379819

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➶

reach

"Elevated lactate levels have been reported to inhibit RIG-I signaling, which could explain our observations (Zhang, et al. 2019) ."

32634445

---

➶

eidos

"Lactate and hexokinase have also recently been found to inhibit RIG-I and MDA5 by interacting with MAVS , which may be significant in explaining the interplay between metabolism and immune signaling as glycolysis was found to be greatly decreased upon RLR signaling ( 329 ) ."

31379819

---

➶

eidos

"Elevated lactate levels have been reported to inhibit RIG-I signaling , which could explain our observations ( Zhang , et al. 2019 ) ."

32634445

---

➶

eidos

"Elevated lactate levels have been reported to inhibit RIG-I signaling , which could explain our observations ( Zhang et al. 2019 ) ."

| PMC

Kaempferol oxoanion affects STAT1

| 6

Kaempferol oxoanion inhibits STAT1. 6 / 6

| 6

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➶

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"Genistein, kaempferol, quercetin, and daidzein also inhibited the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS."

18274639

---

➶

reach

"Here we confirm those findings and show that kaempferol inhibits STAT-1 and NF-kappaB activations, which are implicated in their effects on iNOS expression."

18274639

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➶

reach

"Flavonoids like genistein, kaempferol, quercetin, and daidzein inhibited STAT-1 and NF-kappa B activations in anti-inflammatory effects [XREF_BIBR]."

25183267

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➶

reach

"The mechanisms by which genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 activation are not known, but may be associated with inhibition of phosphorylation of STAT-1 or its up-stream kinase JAK2 [XREF_BIBR]."

18274639

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➶

reach

"In addition, genistein, kaempferol, quercetin, and daidzein also inhibited STAT-1 activation."

18274639

---

➶

reach

"Anti-Inflammatory Effects of Flavonoids : Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-kappaB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-kappaB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages."

18274639

Glutathione affects JUN

| 1 5

Glutathione inhibits JUN. 6 / 6

| 1 5

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➶

medscan

"The antioxidants, N-acetylcysteine and glutathione, but not vitamin C or tiron, inhibited perifosine-induced elevation of p-c-Jun, DR4 and DR5."

21172010

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➶

reach

"We hypothesized that stretch induced cytokine production is dependent on oxidant release and is regulated by intracellular glutathione (GSH) inhibition of nuclear factor kappa B (NF-kappa B) and activator protein-1 (AP-1) binding."

14982601

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➶

reach

"Conversely, there is also evidence that increased cellular glutathione levels by NAC inhibit the expression and transcriptional activity of c-Jun triggered by numerous stimuli XREF_BIBR, including the binding of c-Jun to the AP-1 element within the VEGF promoter XREF_BIBR."

24291398

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➶

reach

"Glutathione depletion inhibits oxidant induced activation of nuclear factor-kappa B, AP-1, and c-Jun and ATF -2 in cultured guinea-pig gastric epithelial cells."

9773928

---

➶

reach

"The nuclear c-Jun phosphorylation was not observed in cells treated with reduced glutathione."

15069077

---

➶

reach

"We hypothesized that stretch induced cytokine production is dependent on oxidant release and is regulated by intracellular glutathione (GSH) inhibition of nuclear factor kappa B (NF-kappa B) and activator protein-1 (AP-1) binding."

14982601

Genistein affects STAT1

| 6

Genistein inhibits STAT1. 6 / 6

| 6

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➶

reach

"Genistein, kaempferol, quercetin, and daidzein also inhibited the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS."

18274639

---

➶

reach

"In addition, genistein, kaempferol, quercetin, and daidzein also inhibited STAT-1 activation."

18274639

---

➶

reach

"Daidzein and genistein also inhibited activations of STAT-1 and NF-kappaB, which are important transcription factors for iNOS [XREF_BIBR, XREF_BIBR]."

18274639

---

➶

reach

"Anti-Inflammatory Effects of Flavonoids : Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-kappaB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-kappaB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages."

18274639

---

➶

reach

"The mechanisms by which genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 activation are not known, but may be associated with inhibition of phosphorylation of STAT-1 or its up-stream kinase JAK2 [XREF_BIBR]."

18274639

---

➶

reach

"Flavonoids like genistein, kaempferol, quercetin, and daidzein inhibited STAT-1 and NF-kappa B activations in anti-inflammatory effects [XREF_BIBR]."

25183267

Gamma-aminobutyric acid affects ITCH

| 6

Gamma-aminobutyric acid inhibits ITCH. 6 / 6

| 6

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"XREF_BIBR Tryptophan produced by the gut microbiome causes an itching sensation in the skin, XREF_BIBR whereas Lactobacillus species and Bifidobacterium species can produce gamma-aminobutyric acid (GABA), which inhibits skin itch."

29949831

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➶

reach

"XREF_BIBR Tryptophan produced by the gut microbiome causes an itching sensation in the skin, XREF_BIBR whereas Lactobacillus species and Bifidobacterium species can produce gamma-aminobutyric acid (GABA), which inhibits skin itch."

29949831

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➶

reach

"Scratch evoked inhibition was also significantly attenuated (but not abolished) by interruption of the upper cervical spinal cord, indicating the involvement of both segmental and suprasegmental circuits that engage glycine- and GABA mediated inhibition of spinal itch signaling neurons by noxious counterstimuli."

21818363

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➶

reach

"A recent study has shown that inhibition of GABA A receptors by bilateral microinjection of bicuculline into the rat CeA dramatically increases scratching behavior in acute and chronic itch models, suggesting a role for inhibitory mechanisms in the CeA in itch modulation XREF_BIBR."

27418284

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➶

reach

"Spinal application of glycine and GABA-A and GABA-B receptor antagonists attenuated or abolished scratch evoked inhibition of spontaneous activity in dorsal horn neurons with input from dry skin, suggesting that GABA and glycine mediate inhibition of itch signaling spinal neurons."

23891755

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➶

reach

"Together with the in situ hybridization data, these results suggest that GABA A Rs inhibit the spinal relay of itch signals primarily at the level of dorsal horn interneurons rather than via inhibition of primary pruritoceptors."

30104684

Gallic acid affects RELA

| 6

Gallic acid inhibits RELA. 6 / 6

| 6

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➶

reach

"The results showed that GA inhibited p65 luciferase activity (by 14.2%, 28.8%, or 57.7%) stimulated with TGFbeta1+ TNFalpha, in a concentration dependent manner."

28404892

---

➶

reach

"Select GA treatment inhibits activated p65."

27764084

---

➶

reach

"XREF_BIBR Epigallocatechin-3-gallate (EGCG), a gallic acid ester of catechin, blocks the production of TNF-alpha, IFN-gamma, NF-kB, and p65, which reduces inflammation in the intestinal mucous membrane."

25349576

---

➶

reach

"However, addition of GA after CDDP treatment could reverse this increase of p65 and p50 in the nucleus."

24300974

---

➶

reach

"As shown in XREF_FIG, neither PS341 nor various doses of GA consistently decreased the nuclear presence of the NF-kappaB p65 subunit in SU-DHL-2 cells."

25853502

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➶

reach

"Although the model used here does not replicate the dementia in human AD, the ability of GA to inhibit activated NF-kappaB p65 and suppress gliosis and inflammatory cytokines suggests potential therapeutic benefits for AD (XREF_FIG)."

30338290

Cisplatin affects STAT1

| 6

Cisplatin inhibits STAT1. 6 / 6

| 6

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"Mean intensity analyses of the images with image J software indicate that the p-STAT3 and p-STAT1 ratio is decreased significantly by cisplatin treatment in the OHC and SG, while SVA showed decreased ratio compared to oral PBS control sections."

30858408

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➶

reach

"[Cisplatin inhibits proliferation of cervical carcinoma cell line by up-regulating Stat1 expression]."

25613616

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➶

reach

"Cisplatin increased STAT1 luciferase activity was attenuated by incubation with EGCG (50muM) (XREF_SUPPLEMENTARY) or by STAT1 short interfering RNA (siRNA) (XREF_FIG)."

21776018

---

➶

reach

"We showed that JWH015 suppressed cisplatin induced STAT1 activation in vitro, which could account for its anti-apoptotic role in UB/OC -1 cell cultures (unpublished data)."

30186120

---

➶

reach

"Cisplatin induced p-STAT1 immunoreactivity in OHCs, IHCs, DCs and IPhCs was attenuated by EGCG (XREF_FIG)."

28703809

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➶

reach

"While it is possible that the protection of hair cells by EGCG in the present study is due in part to its antioxidant effects, the failure of EGCG to provide additional protection of cisplatin treated hair cells from STAT1-/- mice strongly suggests that EGCG prevents cisplatin induced hair cell death primarily by inhibiting STAT1."

19321781

Calcitriol affects RELA

1 | 5

Calcitriol inhibits RELA. 6 / 6

1 | 5

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➶

reach

"These data show that calcitriol prevents TNF-alpha induced increase in importin alpha3 and RelA through a process mediated by the VDR."

22526597

---

➶

reach

"However, addition of 100 nm calcitriol reduces p65 nuclear localization in Mecp2 knock-down neurons without affecting the control neurons (XREF_FIG), indicating that vitamin D supplementation can reduce aberrant NF-kappaB signaling in Mecp2 deficient cortical neurons in vitro."

32393583

---

➶

reach

"Calcitriol treatment significantly attenuated the increase of pNF-kappaB p65 after seawater administration (P < 0.001 versus seawater group)."

25118599

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➶

reach

"The decreased activation of RelA by calcitriol was confirmed by decreased release of RelA inducible molecules, including IL-5, IL-6 and IL-8, by HBSMCs upon calcitriol treatment."

22526597

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➶

ctd

No evidence text available

22615136

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➶

reach

"Calcitriol attenuated BLM induced elevation of nuclear NF-kappaB p65 in the lungs."

26520185

Amiloride affects FOS

| 6

Amiloride inhibits FOS. 6 / 6

| 6

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➶

reach

"Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema."

25557402

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➶

reach

"Amiloride and bumetanide, when added separately or in combination, did not inhibit the induction of c-fos, c-myc, and ODC mRNAs."

2472417

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➶

reach

"Blockade of ENaCs by Amiloride Induces c-Fos Activation of the Area Postrema."

25557402

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➶

reach

"The c-fos cells evoked by NaCl stimulations were observed in the central medial and the external lateral subnuclei in the PBN, and the c-fos cells in the central medial were reduced by amiloride (Tokita, Shimura, Nakamura, Inoue, & Yamamoto,2007; Yamamoto etal.,1993)."

32441441

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➶

reach

"By contrast, c-fos induction, quantified by slit blot hybridization of c-fos mRNA, was not fully inhibited by the reduction of [Na+] o. Furthermore, amiloride and ethylisopropyl-amiloride, inhibitors of Na +/H+ exchange, only partially blocked c-fos induction by serum."

1914252

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➶

reach

"We reasoned that if amiloride blocked the c-Fos activation that occurs after hypertonic saline, these data would support the hypothesis that ENaCs localized in the CVOs may play a role in the brain sodium sensing system."

25557402

Acetic acid affects NLRP3

| 6

Acetic acid inhibits NLRP3. 6 / 6

| 6

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"There is evidence that ketone bodies, beta-hydroxybutyrate (BHB), but not acetoacetate (AcAc) or the structurally related SCFAs, butyrate and acetate, suppress activation of the Nlrp3 inflammasome in response to urate crystals, ATP and lipotoxic fatty acids XREF_BIBR, XREF_BIBR."

29475132

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➶

reach

"Bamboo vinegar decreases inflammatory mediator expression and NLRP3 inflammasome activation by inhibiting reactive oxygen species generation and protein kinase C-alpha and delta activation."

24124509

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➶

reach

"In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes."

29475132

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➶

reach

"Bamboo Vinegar Decreases Inflammatory Mediator Expression and NLRP3 Inflammasome Activation by Inhibiting Reactive Oxygen Species Generation and Protein Kinase C-alpha and delta Activation."

24124509

---

➶

reach

"A study by Youm et al. showed that the NLRP3 inflammasome activation was inhibited by the ketone body beta-hydroxybutyrate (BHB) but not by acetoacetate or by related short-chain fatty acids butyrate and acetate [XREF_BIBR]."

27942750

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➶

reach

"With respect to the effects of SCFAs, Wang et al. reported that the Nlrp3 inflammasome was activated by sodium butyrate in db/db mice XREF_BIBR, while Ho et al. demonstrated that bamboo vinegar decreases inflammatory mediator expression and Nlrp3 inflammasome activation by inhibiting reactive oxygen species (ROS) generation and protein kinase C-alpha and delta activation both in vitro and in vivo XREF_BIBR."

29475132

SB 505124 affects MAPK14

6 |

SB 505124 inhibits MAPK14. 6 / 6

6 |

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➶

tas

No evidence text available

21435890

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➶

tas

No evidence text available

24704197

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➶

tas

No evidence text available

21696866

---

➶

tas

No evidence text available

26483198

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➶

tas

No evidence text available

23047226

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➶

tas

No evidence text available

24786585

NAC affects JUN

| 1 5

NAC inhibits JUN. 6 / 6

| 1 5

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➶

reach

"NAC can inhibit activity of several signal transduction components such as nuclear factor kappa B, activator protein 1, and c- jun N-terminal kinase (JNK) by redox modulation [42, 43]."

10403520

---

➶

reach

"NAC in combination with vanadate appeared to increase the efficacy of c-fos and c-jun inhibition, while decreasing toxicity."

17696279

---

➶

reach

"This work investigated the capacity of alpha-lipoic acid (LA) and N-acetyl-L-cysteine (NAC) to reduce zinc deficiency induced oxidative stress, and prevent the activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), and the cross-talk between both activated cascades through beta-Transducin Repeat containing Protein (beta-TrCP)."

16298762

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➶

reach

"At the molecular level, NAC has been shown to inhibit the activation of C Jun N-terminal kinase, p38 MAP kinase, redox sensitive activating protein-1 (AP-1) and the NF-kappaB transcriptional factor, thereby resulting in the suppression of numerous genes regulating the expression of many cytokines, such as TNF-alpha and IL-1 XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."

25248126

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➶

sparser

"As shown in xref , both 15(S)-HETE and 15(S)-HPETE upregulated the mRNA levels of c-FOS and c-JUN, which was inhibited by NAC."

24732589

---

➶

reach

"showed that the administration of N-acetylocysteine (NAC), a ROS scavenger, reduced colonic cancer cell apoptosis via inhibition of JNK, p38 MAPK and activation of c-jun."

24798211

Heparin affects FOS

| 6

Heparin inhibits FOS. 6 / 6

| 6

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➶

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"Heparin (1 microg/ml) suppressed ionomycin dependent c-fos induction."

9480871

---

➶

reach

"Heparin suppresses the induction of c-fos and c-myc mRNA in murine fibroblasts by selective inhibition of a protein kinase C dependent pathway."

2541434

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➶

reach

"Heparin (1 microg/ml) suppressed the induction of c-fos initiated by all three treatments."

8663360

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➶

reach

"Heparin suppresses the induction of c-fos and c-myc mRNA in murine fibroblasts by se- Steroids, 1995, vol."

7792797

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➶

reach

"Heparin inhibits c-fos and c-myc mRNA ex- pression in vascular smooth muscle cells."

8522393

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➶

reach

"Heparin inhibits Ca2 +/calmodulin-dependent kinase II activation and c-fos induction in mesangial cells."

9480871

Filgotinib affects JAK1

4 | 2

Filgotinib inhibits JAK1. 6 / 6

4 | 2

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➶

reach

"Filgotinib (GLPG0634) is a selective inhibitor of Janus kinase 1 (JAK1) currently in development for the treatment of rheumatoid arthritis and Crohn 's disease."

25681059

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➶

tas

No evidence text available

26351728

---

➶

tas

No evidence text available

25369270

---

➶

tas

No evidence text available

24417533

---

➶

reach

"Filgotinib is another selective inhibitor of JAK1."

32655703

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➶

tas

No evidence text available

Acetylsalicylic acid affects IKBKB

6 |

Acetylsalicylic acid inhibits IKBKB. 6 / 6

6 |

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➶

drugbank

No evidence text available

24874482

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➶

drugbank

No evidence text available

29079505

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➶

drugbank

No evidence text available

10779355

---

➶

drugbank

No evidence text available

11160126

---

➶

drugbank

No evidence text available

21797846

---

➶

drugbank

No evidence text available

14755344

ATP affects RELA

| 6

ATP inhibits RELA. 6 / 6

| 6

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➶

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"Extracellular ATP acting via the P2X 7 receptor activates the transcription factor NF-kappaB by selectively targeting NF-kappaB p65 (Rel A) in the N9 mouse microglial cell line [XREF_BIBR]."

18404484

---

➶

reach

"Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65."

9412459

---

➶

reach

"Extracellular ATP acting via the P2X 7 receptor activates the transcription factor NFkappaB by selectively targeting NFkappaB p65 (Rel A) in the N9 mouse microglial cell line [XREF_BIBR]."

18404429

---

➶

reach

"Using a ChIP assay, we further found that ATP could lower the binding of p65 to potential sites in the OPN promoter region."

24961145

---

➶

reach

"ATP decreased the binding of p65 to potential sites in the OPN promoter region in NPC cells."

24961145

---

➶

reach

"As P2Y2 might be involved in the ATP induced downregulation of p65 and OPN, we further examined the effect of P2Y2 on the level of p65 and OPN by western blotting."

24961145

ATP affects CHUK

| 6

ATP inhibits CHUK. 6 / 6

| 6

---

➶

reach

"Furthermore, to determine whether ATP signaling was sufficient to inhibit the activity of activated IKKalpha, we performed in vitro kinase assay using LPS primed macrophages treated with ATP."

25266676

---

➶

reach

"We therefore speculated that PP2A might play a role in ATP mediated IKKalpha inhibition."

25266676

---

➶

reach

"Instead, we found that PP2A knockdown abolished ATP mediated IKKalpha inhibition (XREF_SUPPLEMENTARY) suggesting that PP2A plays a direct role in inhibiting IKKalpha in response to signal 2 of NLRP3 activation."

25266676

---

➶

reach

"In addition, the inhibition of IKKalpha kinase activity by ATP was not secondary to caspase-1-dependent cell death, as pre-treatment with the caspase-1 inhibitor zYVAD did not prevent ATP mediated IKKalpha inhibition (XREF_SUPPLEMENTARY)."

25266676

---

➶

reach

"ATP inhibits IKKalpha and releases ASC."

25266676

---

➶

reach

"Moreover, ATP mediated IKKalpha inhibition was completely abolished in P2X7R -/- BMDMs (XREF_SUPPLEMENTARY)."

25266676

5z-7-oxozeaenol affects MAP3K7

5 | 1

5z-7-oxozeaenol inhibits MAP3K7. 6 / 6

5 | 1

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➶

reach

"5z-7-oxozeaenol, a TAK inhibitor which binds covalently and blocks the active site permanently, inhibited TAK kinase activity by 77% compared to the no-inhibitor control."

28532672

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➶

tas

No evidence text available

25529738

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➶

tas

No evidence text available

28011204

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➶

tas

No evidence text available

27448772

---

➶

tas

No evidence text available

21316225

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➶

tas

No evidence text available

26481152

2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide affects CHUK

| 6

2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide inhibits CHUK. 6 / 6

| 6

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➶

reach

"Our observation that BAY61-3606 is an inhibitor of IKKalpha has relevance beyond the study of HCMV replication."

26930276

---

➶

reach

"We observed that BAY61-3606 is a potent inhibitor of SYK, GCK and IKKalpha, but not IKKbeta or LYN, a kinase functionally unrelated to IKKalpha (XREF_FIG)."

26930276

---

➶

reach

"Using in vitro kinase assays we found that BAY61-3606 is a potent inhibitor of the cellular kinase IKKalpha."

26930276

---

➶

reach

"Furthermore, we observed that a series of drugs structurally related to BAY61-3606 that do not inhibit IKKalpha had no effect on AD169 replication (XREF_FIG)."

26930276

---

➶

reach

"Therefore, we confirm that BAY61-3606 is an inhibitor of IKKalpha and provide quantitative analysis of IKKalpha kinase inhibition by BAY61-3606."

26930276

---

➶

reach

"Inhibition of IKKalpha by BAY61-3606 Reveals IKKalpha Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells."

26930276

Vitamin D affects NLRP3

| 2 1 3

Vitamin D inhibits NLRP3. 5 / 5

| 2 3

---

➶

eidos

"Vitamin D inhibits NLRP3 activation by impeding its deubiquitination mediated by BRCC3 45 ."

| DOI

---

➶

reach

"Indeed, vitamin C, vitamin D, and omega-3 fatty acids have all been shown to inhibit the NLRP3 inflammasome and may work synergistically against the cytokine storm associated with COVID-19 and specifically against the neuro-inflammation associated with its delirium (67, 68, 69)."

| PMC

---

➶

eidos

"Vitamin D downregulates NLRP3 and protects against toxin-induced cell death 46 and modulates the NLRP3 inflammasome activation 47 ."

| DOI

---

➶

reach

"Vitamin D downregulates NLRP3 and protects against toxin-induced cell death 46 and modulates the NLRP3 inflammasome activation 47 ."

| DOI

---

➶

reach

"•Vitamin D: In certain conditions, vitamin D has been found to decrease NLRP3 inflamasome activation30 and vitamin D receptor activation reduces IL-1b secretion."

32229082

Vitamin D inhibits NLRP3. 1 / 1

| 1

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➶

sparser

"We also showed that vitamin D inhibited AII- or ET-induced cell proliferation and the key cell cycle determinant Cdc25A expression in VSM cells [ xref , xref ], as well as activated natriuretic peptide receptor A expression in VSM cells, and inner medullary collecting duct cells in vitro and in vivo [ xref , xref ]."

22157586

Quercetin affects EIF2AK1

| 3 3

Quercetin inhibits EIF2AK1. 5 / 5

| 2 3

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➶

reach

"We found that similar to human and mouse HRI, canine HRI kinase was inhibited with IC 50 values equal to ~ 1 muM by quercetin, demonstrating that among mammalian HRI, ATP binding and catalysis are conserved."

19946423

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➶

sparser

"In this study, we show that inhibition of HRI by quercetin is able to increase de novo protein translation in canine reticulocytes ( xref ) and also in mouse and rat reticulocytes (data not shown)."

19946423

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➶

reach

"In this study, we show that inhibition of HRI by quercetin is able to increase de novo protein translation in canine reticulocytes (XREF_FIG) and also in mouse and rat reticulocytes (data not shown)."

19946423

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➶

sparser

"To determine the effect of HRI inhibition by quercetin on protein synthesis, we treated canine blood with either 1 or 10 μ M quercetin for 4 hours in the presence of [ 35 S]-methionine ( xref )."

19946423

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➶

reach

"Quercetin, a kinase inhibitor known to inhibit mouse and human HRI, inhibits canine HRI in a concentration dependent manner."

19946423

Quercetin inhibits EIF2AK1. 1 / 1

| 1

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➶

sparser

"Quercetin, a kinase inhibitor known to inhibit mouse and human HRI, inhibits canine HRI in a concentration-dependent manner."

19946423

N-tosyl-L-phenylalanyl chloromethyl ketone affects NFKB1

| 3 3

N-tosyl-L-phenylalanyl chloromethyl ketone inhibits NFKB1. 3 / 3

| 3

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➶

reach

"However, recent studies sug- gest that TPCK inhibits NF-KB activation by interfering IKE]-~ Regulates Persistent Activation of NF-~ B 579 LPS + CHX LPS + TPCK LPS + PDTC am ~ U ~ Sm NF-~ B DNA binding activity 4 am am, l = m = ~ I ~ B-~ protein = m ~ =, *, ~ w ~ I ~ B-c ~ protein Figure 7."

7867065

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➶

reach

"TPCK and TLCK have been shown to prevent the activation of the transcription factor NF-KB by blocking the proteolytic degradation of hcBa in RAW 264.7 macrophages, human monocytes and HeLa cells (4, 16)."

9519810

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➶

reach

"The protease inhibitors TLCK (N alpha-p-Tosyl-L-Lysine Chloromethyl Ketone) and TPCK (N alpha-p-Tosyl-L-Phenylalanine Chloromethyl Ketone) inhibit both p105 to p50 processing and MAD3 degradation, and also cause a complete block to NF-kappa B activation."

8255759

N-tosyl-L-phenylalanyl chloromethyl ketone inhibits NFKB1. 3 / 3

| 3

---

➶

sparser

"The protease inhibitors TLCK (N alpha-p-Tosyl-L-Lysine Chloromethyl Ketone) and TPCK (N alpha-p-Tosyl-L-Phenylalanine Chloromethyl Ketone) inhibit both p105 to p50 processing and MAD3 degradation, and also cause a complete block to NF-kappa B activation."

8255759

---

➶

sparser

"The protease inhibitors TLCK (N alpha-p-Tosyl-L-Lysine Chloromethyl Ketone) and TPCK (N alpha-p-Tosyl-L-Phenylalanine Chloromethyl Ketone) inhibit both p105 to p50 processing and MAD3 degradation, and also cause a complete block to NF-kappa B activation."

8255759

---

➶

sparser

"The protease inhibitors TLCK (N alpha-p-Tosyl-L-Lysine Chloromethyl Ketone) and TPCK (N alpha-p-Tosyl-L-Phenylalanine Chloromethyl Ketone) inhibit both p105 to p50 processing and MAD3 degradation, and also cause a complete block to NF-kappa B activation."

8255759

JSH-23 affects RELA

| 2 4

JSH-23 inhibits RELA. 4 / 4

| 4

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➶

reach

"JSH-23 directly blocks the nuclear localization signal of p65 preventing its accumulation and localization in the nucleus."

27831553

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➶

reach

"IF staining showed that JSH-23 strongly prevented p65 from entering the nucleus in 109-T15 and 9706-T15 cells, whereas few changes were observed in cells treated with DMSO."

29650964

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➶

reach

"In fact, immunofluorescent studies were conducted using anti-p65 antibodies, and inhibition assays using JSH-23 specific inhibitor of p65 subunit of NF-kappaB, a subunit implicated in the classical NF-kappaB pathway only."

24130501

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➶

reach

"But Gm4419 still worked when p65 was inhibited by the p65 specific inhibitor JSH-23."

28151474

JSH-23 inhibits RELA. 2 / 2

| 2

---

➶

sparser

"But Gm4419 still worked when p65 was inhibited by the p65-specific inhibitor JSH-23."

28151474

---

➶

sparser

"But Gm4419 still worked when p65 was inhibited by the p65-specific inhibitor JSH-23."

28151474

Berberine affects IKBKB

| 2 4

Berberine inhibits IKBKB. 4 / 4

| 1 3

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➶

reach

"9 : Berberine is able to reduce inflammatory cytokines expression and inhibit activation of IKK-beta (ser181) in obese mice, which may partly explain the therapeutic effect of berberine on insulin resistance and abnormal glucose metabolism."

20822024

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➶

sparser

"B-α) was phosphorylated by IKK-β and then degraded, inhibition of IKK-β by berberine could result in the stabilization of I??"

29344415

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➶

reach

"In contrast, the same concentration of berberine only inhibited the activity of IKK-beta by 14% in the current study, which suggested that the assay method used in the current study was not as sensitive as the immunocomplex kinase assay."

26937251

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➶

reach

"Berberine could inhibit IKK-beta leading to the stabilized IkappaB-alpha."

30100874

Berberine inhibits IKBKB. 1 / 1

| 1

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➶

sparser

"Berberine could inhibit IKK-β leading to the stabilized IκB-α (Lee et al., xref ; Jia et al., xref ; Li et al., xref )."

30100874

Berberine inhibits IKBKB-C46A. 1 / 1

| 1

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➶

reach

"By contrast, berberine, which is reported to target IKKbeta on Cys 179 [XREF_BIBR], could suppress the IKKbeta C46A activity, implying that Cys 46 is the target of ILG and DMY and not the target of berberine."

27626700

Wogonin affects RELA

| 5

Wogonin inhibits RELA. 5 / 5

| 5

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➶

reach

"The protein expression of NF-kappaB p65, cyclin D1, and Bcl-2 was decreased in cells treated with wogonin, whereas the protein levels of Bax and cleaved caspase-3 were increased significantly (P < 0.05)."

29451160

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➶

reach

"Moreover, p65 was reduced by Wogonin in the nucleus of resistant CML cells, and the analysis showed reduction of both Nrf2 and p65 nuclear protein levels to correlate in a 1:1 manner (XREF_FIG and XREF_FIG, also in XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY)."

28150717

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➶

reach

"As illustrated in XREF_FIG, data showed Wogonin significantly reduced the effective binding of p65 to the biotin labeled oligonucleotide Nrf2 probe (including kappaB2 site)."

28150717

---

➶

reach

"Wogonin inhibits the growth of transplantable tumors and down-regulates protein level of p65 and PU.1."

28222771

---

➶

reach

"Phosphorylated NF-kappaB p65 was enhanced with the stimulation by wogonin (50 or 100 mug/ml), although total p65 was decreased by 100 mug/ml wogonin."

27641629

Withaferin A affects NLRP3

| 1 4

Withaferin A inhibits NLRP3. 5 / 5

| 1 4

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➶

reach

"Finally, we determined whether WA can directly inhibit ac tivation of the NLRP3 inflammasome."

26770181

---

➶

eidos

"In addition , withaferin A and kaempferol inhibit NLRP3 via indirect mechanisms ."

| PMC

---

➶

reach

"Notably, WA significantly reduced the activation of the NLRP3 inflammasome."

30468675

---

➶

reach

"In addition, withaferin A and kaempferol inhibit NLRP3 via indirect mechanisms."

| PMC

---

➶

reach

"Furthermore, WA inhibited the NLRP3 inflammasome induced by ATP, nigericin, and MSU, which are well known NLRP3 activators."

26770181

Vorinostat affects NFKB1

2 | 3

Vorinostat inhibits NFKB1. 5 / 5

2 | 3

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➶

reach

"SAHA treatment also decreased the basal level of NFkB activity in H-INV cells."

27634890

---

➶

reach

"At the molecular level, it was found that upregulation of IkappaBalpha and the p50 and p65 subunits of nuclear factor-kappaB induced by ZD55-TRAIL, can be abrogated by SAHA treatment."

25684632

---

➶

reach

"But HMGB1 was required for SAHA induced suppression of NF-kappaB1."

26557438

---

➶

ctd

No evidence text available

12893773

---

➶

ctd

No evidence text available

19643600

Troglitazone affects FOS

| 5

Troglitazone inhibits FOS. 5 / 5

| 5

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➶

reach

"Troglitazone (1-20 microM), a member of the thiazolidinediones, significantly inhibited the stimulation of alpha1-adrenoreceptor-induced DNA synthesis, c-fos induction and mitogen activated protein (MAP)-kinase activation."

10422649

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➶

reach

"Inhibition of c-fos induction by troglitazone appeared to occur via a blockade of the MAP kinase pathway at a point downstream of MAP kinase activation by MAP kinase kinase."

8878442

---

➶

reach

"Further, troglitazone also activates ERK1/2 [XREF_BIBR] and blocks c-fos synthesis [XREF_BIBR] which could also modulate these effects."

15694007

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➶

reach

"Troglitazone (1 microM), a member of the thiazolidinedione class, produced a near complete inhibition of both bFGF induced DNA synthesis as measured by bromodeoxyuridine incorporation (6.5 +/-3.9 vs. 17.6 +/-4.3% cells labeled, P < 0.05) and c-fos induction."

8878442

---

➶

reach

"Inhibition of c-fos induction by troglitazone appeared to occur via blockade of the upstream of MAP kinase activation in vascular smooth muscle cells."

10422649

Trichostatin A affects RELA

2 | 3

Trichostatin A inhibits RELA. 5 / 5

2 | 3

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➶

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"TSA does not alter the translational efficiency or degradation of TF, but inhibits the binding of NF-kappaB components (cRel and p65 and p65 and p507) to the unique sites that are specific for VCAM and TF."

24957668

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➶

ctd

No evidence text available

25232110

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➶

reach

"As shown for early transcription and late transcription, the stimulatory effect of TSA was partially reversed by p65 siRNA but not NT siRNA indicating the involvement of p65 in at least part of the effect of TSA on JCV transcription."

23971673

---

➶

reach

"First of all, we examined if trichostatin A (TSA), a HDAC inhibitor, could reverse the effect of p65 on the ARE mediated gene expression."

18241676

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➶

ctd

No evidence text available

16904634

Ticagrelor affects NLRP3

| 5

Ticagrelor inhibits NLRP3. 5 / 5

| 5

---

➶

reach

"Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y"

32523112

---

➶

reach

"Ticagrelor, a P2Y12 receptor antagonist, and dapagliflozin, a sodium-glucose-cotransporter-2 inhibitor, suppress the activation of the NLRP3 inflammasome."

32335797

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➶

reach

"In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on the P2Y 12 signaling pathway."

32523112

---

➶

reach

"Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome."

32523112

---

➶

reach

"Both dapagliflozin and ticagrelor attenuated the progression of diabetic cardiomyopathy, the activation of the NLRP3 inflammasome, and fibrosis in BTBR mice with additive effects of the combination."

32335797

Sunitinib affects JAK1

5 |

Sunitinib inhibits JAK1. 5 / 5

5 |

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➶

tas

No evidence text available

22037378

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➶

tas

No evidence text available

18077425

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

15711537

---

➶

tas

No evidence text available

19654408

Sorafenib affects RIPK1

| 5

Sorafenib inhibits RIPK1. 5 / 5

| 5

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➶

reach

"43 Sorafenib inhibits both RIPK1 dependent apoptosis and necroptosis, which may explain its protective effect during TNF induced SIRS model."

28661484

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➶

reach

"In order to test whether Sorafenib directly inhibits kinase activities of RIPK1 or RIPK3, different in vitro kinase assays were performed (XREF_FIG)."

28661484

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➶

reach

"67 As Sorafenib is not specifically inhibiting necroptosis but also RIPK1 kinase dependent apoptosis, one could envisage that during experimental disease models in vivo it may target simultaneously RIPK1 dependent necroptosis and apoptosis."

28661484

---

➶

reach

"This demonstrates that Sorafenib inhibits RIPK1 dependent apoptosis and necroptosis equally, but not RIPK1 independent apoptosis."

28661484

---

➶

reach

"Indeed, there is recent evidence indicating that Sorafenib inhibits RIP1 and RIP3 kinase activity [XREF_BIBR]."

28978109

Sorafenib affects MAP3K7

2 | 3

Sorafenib inhibits MAP3K7. 5 / 5

2 | 3

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➶

reach

"However, the multikinase inhibitor sorafenib [XREF_BIBR], which has already been proven to be clinically effective in the treatment of various malignancies, inhibits MAP3K7 and may specifically target leukemias with low expression of MAP3K7 [XREF_BIBR, XREF_BIBR]."

29914415

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

19654408

---

➶

reach

"TAK1 is considered a tumor suppressor in hepatocytes.36 However, signaling network topologies are different between hepatocytes and HCC cells, and specific changes to the connections involving MEKK1 and TAK1 in HCC have been observed.37 Furthermore, the major drug currently used in treating advanced HCC, the multikinase inhibitor sorafenib,10 was recently shown to inhibit TAK1 activity in keratinocytes.38 These data suggest that HCC may involve co-opting TAK1 signaling in later stages of disease progression."

27567007

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➶

reach

"In agreement with our in vitro data, sorafenib was demonstrated to potently inhibit TAK1 kinase activity (IC50 = 1.5 microM) (XREF_FIG)."

26677977

Sitosterol affects DDX58

| 1 4

Sitosterol inhibits DDX58. 5 / 5

| 1 4

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➶

reach

"These results suggest that beta-sitosterol treatment antagonizes the RIG-I signaling cascades."

| PMC

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➶

sparser

"To examine the effect of RIG-I inhibition by β-sitosterol on the transcription of IFN signaling-related molecules, we analyzed IAV-mediated IFN-stimulated response element (ISRE) activation with an assay that utilized a transient ISRE reporter plasmid."

| PMC

---

➶

reach

"Our results show that beta-sitosterol decreased the induction of RIG-I in infected A549 cells."

| PMC

---

➶

reach

"Therefore, the inhibition of STAT1 phosphorylation in response to IFN-beta treatment for 15min or 24h can be attributed to the downregulation of RIG-I by beta-sitosterol."

| PMC

---

➶

reach

"Collectively, these data suggest that beta-sitosterol inhibits the activation of RIG-I signaling and downstream apoptosis in response to vRNA."

| PMC

Retinoic acid affects FOS

| 5

Retinoic acid inhibits FOS. 5 / 5

| 5

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➶

reach

"RA blocked c-fos induction by inhibiting transcription."

1400313

---

➶

reach

"C-fos is downregulated by RA in parallel to the inhibition of the cell division rate."

9507049

---

➶

reach

"We have recently shown that RA attenuates the response of NGFI-B and c-Fos to NGF, but does not alter NGF induction of NGFI-A [12]."

10094483

---

➶

reach

"RA attenuates the response of NGFI-B and c-Fos to NGF, but does not alter NGF induction of NGFI-A."

9662427

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➶

reach

"That repression of c-fos by RA might contribute to anti-AP-1 activity was suggested by experiments with an antisense c-fos expression vector, which demonstrated that c-fos induction was required for serum stimulated AP-1 activity."

7977784

Resveratrol affects MYD88

1 | 4

Resveratrol inhibits MYD88. 5 / 5

1 | 4

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➶

reach

"In human chondrocytes, resveratrol can remarkably suppress the upregulation of TLR4 and the downstream target MyD88 and TRAF6 induced by IL-1beta [XREF_BIBR]."

28203259

---

➶

reach

"For example tumor growth factor-beta selectively inhibits the MyD88 dependent pathway and the natural product resveratrol has been shown to selectively inhibit the MyD88 independent pathway (TRIF)."

20006962

---

➶

reach

"Specific inhibition of MyD88 independent signaling pathways of TLR3 and TLR4 by resveratrol : molecular targets are TBK1 and RIP1 in TRIF complex."

16116226

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➶

reach

"Furthermore, the suppressive effect of resveratrol on LPS induced NF-kappaB activation was abolished in TRIF deficient mouse embryonic fibroblasts, but not in MyD88 deficient macrophages (XREF_FIG), suggesting that resveratrol specifically inhibits MyD88 independent signaling pathways downstream of TLR3 and TLR4."

21631512

---

➶

ctd

No evidence text available

24617573

Resveratrol affects MAP3K7

| 5

Resveratrol inhibits MAP3K7. 5 / 5

| 5

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➶

reach

"Resveratrol limited the activation of TAK1 and its downstream signaling pathway, including the degradation of IkappaBalpha, the activation of NF-kappaB P65 and the phosphorylation of P38 and JNK."

30537632

---

➶

reach

"In vitro and in vivo data showed that resveratrol inhibited TAK1 activation, inflammation and fibrosis in experimental pneumoconiosis."

28698801

---

➶

reach

"To achieve pharmacological TAK1 inhibition, we virtually screened out a natural product resveratrol, which targeted TAK1 at both N161 and A107 residues, and significantly inhibited TAK1 activation to attenuate inflammation and fibrosis in vitro."

28698801

---

➶

reach

"Consistent with the virtual screening data, our in vitro data demonstrated that the screened resveratrol effectively inhibited TAK1 activation, inflammatory response in cultured alveolar macrophage NR8383 cells with silica exposure and fibrotic response in cultured lung fibroblast WI-38 cells with TGF-beta stimulation in vitro."

28698801

---

➶

reach

"Furthermore, TAK1 inhibition by resveratrol may also pave the way for treatment of other lung diseases, which are characterized with pulmonary inflammation and fibrosis."

28698801

Quinacrine affects RELA

| 5

Quinacrine inhibits RELA. 5 / 5

| 5

---

➶

reach

"These results indicate that quinacrine inhibits the binding of p65 to the ICAM-1 promoter."

29207489

---

➶

reach

"In the present study, the ChIP assay clearly showed that quinacrine inhibited the binding of p65 to the ICAM-1 promoter in intact A549 cells."

29207489

---

➶

reach

"In contrast, quinacrine strongly reduced the subsequent binding of p65 to the ICAM-1 promoter, indicating that quinacrine inhibits TNF-alpha-induced NF-kappaB-dependent transcriptional activation in A549 cells."

29207489

---

➶

reach

"Quinacrine Inhibits the Binding of p65 to the ICAM-1 Promoter."

29207489

---

➶

reach

"In contrast, a chromatin immunoprecipitation assay showed that quinacrine prevented the binding of p65 to the ICAM-1 promoter following TNF-alpha stimulation."

29207489

Pyrrolidine affects NFKB1

| 5

Pyrrolidine inhibits NFKB1. 5 / 5

| 5

---

➶

reach

"Furthermore, recent findings regarding both the specific inhibition of NF-KB by pyrrolidine dithiocarbamate and the subsequent block of the production of NO in LPS treated murine macrophages strongly indicate that Nitric oxide in the liver,, epalocyle NOS Giycogenbi ~ ownt [c- 2+] t _ MS NO - Glycys> s ~ \ ~ Pmteinsynthesis ~, \ NO I, PSlmicrobes parasites and tumor cells IFN-y GM-CSF _ 1VI ~ CSF ILl (i 1 ' NFu i iCCK PGF2 ~ 2 NO R iCOX NO /% uper cell Noses TGF- 389 Ito cell NOS cNOS cNOS NOS ND Endothelial cell Fig. 5."

8746512

---

➶

reach

"The signal (s) leading to activation of NF-KB remains to be identified, but the fact that the antioxidant pyrrolidine dithiocarbamate (PDTC) blocks NF-KB activation suggests that cytokine-in- * Corresponding author."

8641463

---

➶

reach

"Third, the antioxidant pyrrolidine dithiocarbamate inhibits NF-KB activation by okadaic acid."

9383399

---

➶

reach

"Pyrrolidine dithiocarbamate inhibits the production of interieukin-6, interieukin-8, and granulocyte-macrophage colony stimulating factor by human endothelial cells in response to inflammatory mediators : modulation of NF-KB and AP-1 transcription factors activity."

9442398

---

➶

reach

"Recent in vivo studies have further suggested that the physiological redox regulator protein thioredoxin and the radical scavenger pyrrolidine dithiocarbamate both inhibit NF-KB activation after PMA treatment (Meyer et al., 1993; Schenk et al., 1994)."

7584622

Pyrrolidine dithiocarbamate affects RELA

4 | 1

Pyrrolidine dithiocarbamate inhibits RELA. 5 / 5

4 | 1

---

➶

ctd

No evidence text available

15382119

---

➶

reach

"Compared to the group with palmitate treatment alone, pyrrolidine dithiocarbamic acid (10/20 micromol/L) significantly inhibited the palmitate induced increase of p-NF-kappaB p65 (1.39 +/- 0.12, 1.25 +/- 0.10 vs 1.76 +/- 0.14, both P < 0.05), restored the palmitate induced decrease of caspase-3 (2.24 +/- 0.28 vs 1.29 +/- 0.27, P < 0.05) and inhibited the palmitate induced increase of cleaved caspase-3 (0.63 +/- 0.01 vs 1.13 +/- 0.10, P < 0.05)."

24851897

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➶

ctd

No evidence text available

10661865

---

➶

ctd

No evidence text available

14527959

---

➶

ctd

No evidence text available

18593918

Pyrimidine affects DDX58

| 5

Pyrimidine inhibits DDX58. 5 / 5

| 5

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➶

reach

"After more extensive search, the only piece of supportive evidence we obtained so far is that a pyrimidine inhibitor identified as a broad-spectrum antiviral was found to activate RIG-I, an essential cellular sensor to mount innate immune response in virus infection, especially influenza virus infection."

30498026

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➶

reach

"More recently, it was shown that pyrimidine biosynthesis inhibitors could increase the expression of retinoic acid-inducible gene 1 (RIG-I), a cytoplasmic sensor inducing the expression of innate immunity genes and IFNs in response to RNA virus infections (16)."

28807907

---

➶

reach

"More recently, a pyrimidine inhibitor identified as a broadspectrum antiviral was found to activate RIG-I (Chung et al, 2016) , an essential cellular sensor to mount innate immune response in influenza virus infection (Loo et al, 2008) ."

30498026

---

➶

reach

"However, we did not confirm this observation in HEK-293 cells (XREF_FIG and XREF_FIG and XREF_FIG), suggesting that RIG-I induction by pyrimidine biosynthesis inhibitors alone is cell type dependent."

28807907

---

➶

reach

"However, we did not confirm this observation in HEK-293 cells (Fig. 7A and B and 8B), suggesting that RIG-I induction by pyrimidine biosynthesis inhibitors alone is cell type dependent."

28807907

Pyridine affects MAP3K7

| 5

Pyridine inhibits MAP3K7. 5 / 5

| 5

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➶

reach

"The discovery and potency optimization of a series of 7-aminofuro [2,3-c] pyridine inhibitors of TAK1 is described."

23850198

---

➶

reach

"More recently, a series of 7-aminofuro [2,3-c] pyridine inhibitors of TAK1 have been described [XREF_BIBR]."

25557171

---

➶

reach

"The kinase selectivity and pharmacokinetic optimization of a series of 7-aminofuro [2,3-c] pyridine inhibitors of TAK1 is described."

23856049

---

➶

reach

"Discovery and optimization of 7-aminofuro [2,3-c] pyridine inhibitors of TAK1."

23850198

---

➶

reach

"Discovery of 7-aminofuro [2,3-c] pyridine inhibitors of TAK1 : optimization of kinase selectivity and pharmacokinetics."

23856049

Pseudouridine affects DDX58

| 5

Pseudouridine inhibits DDX58. 5 / 5

| 5

---

➶

reach

"Moreover, N-6-methyladenosine (m6A) and pseudouridine within a polyU/UC RNA domain of hepatitis C virus were tested for cytosolic RIG-I stimulation and showed to reduce RIG-I signaling."

30699960

---

➶

reach

"Moreover, N-6-methyladenosine (m6A) and pseudouridine within a polyU/UC RNA domain of hepatitis C virus were tested for cytosolic RIG-I stimulation and showed to reduce RIG-I signaling."

30699960

---

➶

reach

"Additionally, the presence of m 6 A and pseudouridine in viral RNA was recently shown to attenuate the activation of the RIG-I innate signaling pathway."

29373715

---

➶

reach

"In addition, abundant cellular RNAs, such as tRNAs and rRNAs, are extensively modified with unusual bases, such as pseudouridine, which prevent the activation of RIG-I and MDA5 (ReF."

18989317

---

➶

reach

"Additionally, the presence of m6A and pseudouridine in viral RNA was recently shown to attenuate the activation of the RIG-I innate signaling pathway (33)."

29373715

Propofol affects RELA

| 1 2 2

Propofol inhibits RELA. 5 / 5

| 1 2 2

---

➶

eidos

"As illustrated in Figures5 ( a ) -5 ( c ) , compared to the CoCl2-treated group , propofol significantly suppressed NF-kappaB p65 and Hif-1alphaproduction ( P < 0.05 ) ."

32420378

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➶

reach

"As illustrated in Figures XREF_FIG - XREF_FIG, compared to the CoCl 2 -treated group, propofol significantly suppressed NF-kappaB p65 and Hif-1alpha production (P < 0.05)."

32420378

---

➶

reach

"To assess NFkappaB (p65) nuclear translocation, serum starved H9c2 cells were treated with 50 muM propofol for 10 min, 30 min, 1 h, 2 h, and 4 h and stained for p65 and DAPI, a nuclear specific dye."

25105067

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➶

sparser

"Propofol inhibited CFA-induced expression of p-extracellular signal-regulated kinase1/2 (p-ERK1/2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65, as demonstrated by Western blot analysis."

30536812

---

➶

sparser

"Propofol inhibited CFA-induced expression of p-extracellular signal-regulated kinase1/2 (p-ERK1/2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65, as demonstrated by Western blot analysis."

30536812

Propofol affects FOS

| 1 2 2

Propofol inhibits FOS. 5 / 5

| 1 2 2

---

➶

reach

"Propofol inhibited c-Fos and Arc in brain, which has been recognized as molecular mechanisms of propofol induced cognitive dysfunction (Kozinn et al., 2006; Ren et al., 2008; Whittington et al., 2013)."

26921778

---

➶

reach

"Taken together, these results suggested that propofol inhibited Arc and c-Fos, two downstream products pending on PARP-1 activation, at both protein and mRNA levels.Val762Ala lies within the catalytic domain of PARP-1 protein, and replacing valine with alanine when C> T causes decrease in PARP-1 enzyme activity (Wang et al., 2007)."

26921778

---

➶

medscan

"Rodent data demonstrated that propofol inhibited acquisition-induced increase in PARP-1 and PAR, thereby suppressing Arc and c-Fos, which impaired object recognition 24h after learning."

26921778

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"Taken together, these results suggested that propofol inhibited Arc and c-Fos, two downstream products pending on PARP-1 activation, at both protein and mRNA levels."

26921778

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"Propofol inhibited c-Fos and Arc in brain, which has been recognized as molecular mechanisms of propofol-induced cognitive dysfunction ( Kozinn et al., 2006; Ren et al., 2008; Whittington et al., 2013 )."

26921778

Phenethyl caffeate affects NFKBIA

| 5

Phenethyl caffeate inhibits NFKBIA. 5 / 5

| 5

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"Maximum inhibition by CAPE was observed at concentrations of 25 microg ml (-1) (approximately 88 microM) CAPE prevented H. pylori- and cytokine induced degradation of IkappaB-alpha protein."

16247412

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"Further, p-IkappaB-alpha, an activated (phosphorylated) form of IkappaB-alpha, and IkappaB-beta, inhibitors of NF-kappaB1 & 2, respectively, were decreased by CAPE to about the same degree (i.e., ~ 44% at 20 microM CAPE) (XREF_TABLE)."

21570765

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"Further, p-IkappaB-alpha, an activated (phosphorylated) form of IkappaB-alpha, and IkappaB-beta, inhibitors of NF-kappaB1 & 2, respectively, were decreased by CAPE to about the same degree (i.e., ~ 44% at 20 microM CAPE) (XREF_TABLE), There were no changes observed in the levels of IkappaB-alpha and C-rel proteins."

21570765

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"It has also been reported that CAPE inhibits NF-kappaB activation not by blocking the degradation of IkappaBalpha but by suppressing the interaction of NF-kappaB proteins with the DNA [14]."

11734336

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"For inhibiting the IKKbeta/IkappaBalpha/NF-kappaB and JNK/AP -1 signal pathway, CAPE clearly diminished the activation of IKKbeta, IkappaBalpha (inhibitory proteins of NF-kappaB), and JNK through phosphorylation."

29957360

Parathion affects TLR7

| 5

Parathion inhibits TLR7. 5 / 5

| 5

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"Although the inhibitory effect of select LNA and DNA AMOs was surprising, it is consistent with a previous report that phosphorothioate DNA oligonucleotides can inhibit TLR7 sensing in a sequence dependent manner."

25539920

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"However, an RNA dependent TLR7 IFN-alpha cytokine release is suppressed by the phosphorothioate DNA sequence contained in the chimeric molecule."

22196370

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"Such miRNA independent TLR7 inhibition by these LNA and DNA phosphorothioate AMOs is rather in line with previous studies that reported the specific inhibition of R848 and immunostimulatory ssRNA driven TLR7 activation, by phosphorothioate DNA oligonucleotide (ODN) in human HEK293 TLR7 cells and in mouse splenocytes."

25539920

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"Peripheral blood mononuclear cells (PBMC) and peripheral lymph node cell suspensions from healthy SIV-naive macaques were incubated with aldrithiol-2-inactivated SIVmac239 particles (iSIV) or influenza virus in the presence or absence of DV056, a 25 based single stranded phosphorothioate oligodeoxynucleotide antagonist of TLR7 and TLR9 that contains the necessary inhibitory motifs with optimization for activity in nonhuman primates and humans XREF_BIBR."

23935491

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"We establish that this effect relies on an inhibitory motif present in more than 50 miRNA AMOs, and that LNA and DNA phosphorothioate AMOs can also inhibit TLR7 in a sequence dependent manner."

25539920

Palbociclib affects JUN

| 3 2

Palbociclib inhibits JUN. 5 / 5

| 3 2

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medscan

"Palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-Jun/COX-2 signaling pathway"

26540629

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medscan

"These data indicate that palbociclib prevented MDA-MB-231-Luc cells from metastasizing and decreased the expression of Cyclooxygenase-2 and c-Jun in vivo."

26540629

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reach

"These data indicate that palbociclib prevented the entry of c-Jun to the nucleus to promote COX-2 transcription."

26540629

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medscan

"The translocation of c-Jun was also prevented by palbociclib."

26540629

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reach

"Additionally, our data showed that c-Jun, a crucial transcriptional regulator of COX-2, was down-regulated by palbociclib."

26540629

Nitric oxide affects JUN

| 1 4

Nitric oxide inhibits JUN. 5 / 5

| 1 4

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"Furthermore, in both models of apoptosis, NO releasing compounds dose-dependently reduced : (a) the number of the titratable thiol groups (cysteine residues) of c-Jun; (b) induction of AP-1 DNA binding activity; (c) AP-1-driven transactivation of the CD95L promoter; and (d) caspase activation."

10811113

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reach

"Nitric oxide inhibits IgE dependent cytokine production and Fos and Jun activation in mast cells."

15557187

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➶

reach

"NO attenuated the binding of activator protein-1 to the 12-O-tetradecanoylphobol-13-acetate-responsive element (TRE) in the MCP-1 promoter region."

11742868

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medscan

"Nitric oxide inhibits an interaction between JNK1 and c-Jun through nitrosylation."

17054907

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reach

"NO prevents the activity of Jun N-terminal kinase1 (JNK1) by S nitrosylation that leads to reduction in Bcl-2 phosphorylation."

26330869

Nigericin affects NLRP3

| 5

Nigericin inhibits NLRP3. 5 / 5

| 5

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"We observed that loading LPS primed BMDC with BAPTA markedly attenuated multiple readouts of nigericin stimulated NLRP3 inflammasome signaling including total IL-1beta release (XREF_FIG), extracellular accumulation of p20 caspase-1 subunit and p17 mature IL-1beta (XREF_FIG), formation of ASC oligomers (XREF_FIG), and induction of pyroptotic propidium 2+ influx (XREF_FIG)."

25762778

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"Importantly, the additional presence of glycine to attenuate cell lysis did not modulate the effects of the lanthanides on nigericin stimulated NLRP3 inflammasome signaling and IL-1beta export (XREF_FIG)."

27385778

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reach

"Suppression of nigericin stimulated NLRP3 inflammasome signaling by BAPTA and 2-APB can be dissociated from perturbation of Ca 2+ signaling."

25762778

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reach

"To demonstrate the effect of ADAM10 depletion was specific to Hla induced cell death and not generally suppressive of NLRP3 activation, siRNA transfected cells were also treated with nigericin, a pore forming toxin known to activate NLRP3, and assessed for cell death [XREF_BIBR]."

27043625

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"We confirmed previously reported observations that pre-treatment of LPS primed myeloid cells with 2-APB prior to stimulation by nigericin (or ATP) completely suppresses all indices of the activated NLRP3 signaling cascade."

25762778

Morphine(1+) affects ITCH

| 5

Morphine(1+) inhibits ITCH. 5 / 5

| 5

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"Further, blocking formation of MOR1D-GRPR receptor heteromers by injection of a TAT fusion peptide (TAT-MOR1Dct) into spinal cord led to reduction of morphine induced itch but had no effect on morphine induced analgesia."

24281378

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"In fact, knockdown of one MOR isoform, MOR1D, in the spinal cord significantly attenuates morphine induced scratching while knockdown of MOR1 reduces morphine induced analgesia, suggesting that MOR1D and MOR1 play central roles in morphine induced itch and pain inhibition, respectively [XREF_BIBR]."

25894692

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"XREF_BIBR, XREF_BIBR - XREF_BIBR Current published studies provide a very poor rationale for the usage of SRAs, which may be attributable to the limited success in morphine induced itch, probably by interfering with muopioid receptors on the spinal cord level."

21767775

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"These responses represent noxious behaviors because they were markedly attenuated by intraperitoneal injection (i.p.) of morphine (10mg/kg, i.p.), which would reduce pain but not itch related scratching response 30."

29133874

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"We describe a case of severe morphine induced itch unrelieved by antihistamines, which responded to a change to hydromorphone."

9919868

Minocycline affects NLRP3

| 5

Minocycline inhibits NLRP3. 5 / 5

| 5

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"Meanwhile, we showed that minocycline prevented the activation of microglias and attenuated NLRP3 inflammasome signaling after tMCAO injury."

27846628

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reach

"Accordingly, minocycline mediated Nlrp3 inflammasome inhibition and amelioration of dNP are abolished in diabetic Nrf2 -/- mice."

27721446

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reach

"Furthermore, we found that the pretreatment of minocycline significantly inhibited signal 1 and signal 2 of NLRP3 inflammasome activation in BV2 cells."

27846628

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reach

"Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke."

27846628

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reach

"Furthermore, the minocycline mediated NLRP3 inflammasome inhibition and its subsequent therapeutic effect in DN was absent in diabetic Nrf2 KO mice, thereby implicating Nrf2 protection at the level of the inflammasome."

29515457

Metformin affects IKBKB

| 5

Metformin inhibits IKBKB. 5 / 5

| 5

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"Inasmuch as metformin has been shown to reduce IKKbeta activity in various tissues, IkappaBalpha was measured as an indicator of IKKbeta action."

20798864

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"The aim of this study was to (1) determine the ability of metformin to attenuate IKKbeta action, (2) determine whether changes in AMPK activity are associated with changes in IKKbeta action in skeletal muscle, and (3) examine whether changes in AMPK and IKKbeta function are consistent with improved insulin signaling."

20798864

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reach

"Work in endothelial cells and liver has shown that metformin can reduce IKKbeta activity, raising the possibility that activation of AMPK may be a mechanism by which metformin improves insulin sensitivity in skeletal muscle."

20798864

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reach

"Metformin and resveratrol blocked JNK and IKKbeta inflammatory signaling and effectively preserved PDE3B activity, presenting another pathway through which to reduce cAMP accumulation."

27343375

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"Therefore, the aim of this study was to (1) determine whether metformin attenuates IKKbeta activity in skeletal muscle of obese rats, (2) determine whether changes in AMPK are associated with reduced IKKbeta activity in skeletal muscle, and (3) examine whether a decrease in IKKbeta activity coincides with reduced phosphorylation of Ser 307 on IRS1 in skeletal muscle and whether this translates into increased glucose tolerance."

20798864

Lithium(1+) affects STAT1

| 5

Lithium(1+) inhibits STAT1. 5 / 5

| 5

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"Lithium also inhibited STAT1 activation induced by IFN-beta with or without anti-CD3 costimulation (XREF_FIG)."

23285134

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"We then evaluated if lithium dependent inhibition of pSTAT1 would affect the generation and expansion of Th1 cells by MOG 35-55 restimulation under Th1 polarizing conditions (XREF_FIG)."

23285134

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➶

reach

"This result demonstrates that although lithium inhibits STAT1 activation initiated by IFNAR engagement (XREF_FIG), the type I IFN receptor is dispensable for lithium 's therapeutic activity in EAE (XREF_FIG)."

23285134

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➶

reach

"However, lithium did inhibit STAT1 activation in B-cells and CD8 + T cells (XREF_SUPPLEMENTARY)."

23285134

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➶

reach

"Both continuous and acute lithium treatment significantly inhibited STAT1 activation in Th1 cells (XREF_FIG)."

23285134

Lithium(1+) affects NFKB1

| 5

Lithium(1+) inhibits NFKB1. 5 / 5

| 5

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"We thus initially thought that the induction of p105 degradation and Tpl2 activation by lithium might be due to inhibition of GSK3beta."

19159680

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"Lithium induces degradation of p105 and liberation of Tpl2."

19159680

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reach

"A recent study has shown that long-term use of lithium can reduce p105 content in macrophages and inhibit lipopolysaccharide (LPS)-mediated NF-kappaB activation, which results in macrophage apoptosis 43."

29756516

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reach

"Lithium activates Tpl2 by inducing degradation of p105, an NF-kappaB precursor protein that functions as a physiological inhibitor of Tpl2."

19159680

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reach

"A major signaling function of lithium is to stimulate degradation of the NF-kappaB1 precursor protein p105."

19159680

Liraglutide affects NLRP3

| 5

Liraglutide inhibits NLRP3. 5 / 5

| 5

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"These results show that liraglutide attenuated the mitochondrial dysfunction and suppressed NLRP3 inflammasome activation in KCs.In the present study, we showed that liraglutide reduced lipid accumulation and hepatic steatosis by inhibiting the activation of NLRP3 inflammasome both in vivo and in vitro, suggesting that liraglutide is a potent drug that can reverse the pathological hallmarks of NAFLD.A growing body of evidence supports a key role for lipid peroxidation in the pathogenesis of steatosis."

30269815

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"Moreover, the NLRP3 positive cells in the livers were also decreased by liraglutide treatment."

30269815

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reach

"This may have been mediated by the inhibition of NLRP3 inflammasome activation.Next, we investigated whether liraglutide could inhibit palmitic acid (PA) induced NLRP3 inflammasome activation in Kupffer cells."

30269815

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reach

"Our results found that liraglutide could reduce the NLRP3 inflammasome induced by HFD and decrease the IL-1beta secretion or caspase-1 and asc production in liver."

30269815

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reach

"We examined whether liraglutide reduced the NLRP3 inflammasome and relieved NAFLD.In the future, we will investigate the mechanism by which liraglutide inhibits the NLRP3 inflammasome."

30269815

Lipopolysaccharide affects MAP3K7

| 5

Lipopolysaccharide inhibits MAP3K7. 5 / 5

| 5

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"Then, we found that Fpr2 inhibition markedly reduced the activation of transforming growth factor beta activated kinase 1 (TAK1) induced by LPS."

32106380

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"We further found that LPS induced degradation of IRAK1 and phosphorylation of TAK1 were markedly inhibited in a berterion concentration dependent manner without changes in the levels of TLR4, MyD88, or TAK1 (XREF_FIG A)."

25393510

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"CPEB1 and CPEB4 knockdowns suppressed LPS activated TAK1 signaling cascades by reducing the levels of TNF-alpha and phosphorylated TAK1, p38, ERK, JNK, and NF-kappaB-p65 in THP-1cells."

32113875

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"As in the above studies, the LPS induced activation of TAK1 and IKK were both markedly reduced and delayed in Dream -/- cells compared with WT (XREF_SUPPLEMENTARY)."

24487321

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➶

reach

"4 '-HW suppressed LPS induced degradation of IkappaB-alpha and activation of IKK and TAK in RAW 264.7 macrophages."

28792498

Lipopolysaccharide affects IKBKB

| 5

Lipopolysaccharide inhibits IKBKB. 5 / 5

| 5

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"These findings are in agreement with the observed decrease in LPS induced IKKbeta activity by estradiol in endothelial cells as well as the estradiol mediated reduction of IkappaBalpha phosphorylation in cerebral ischemia."

20351193

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reach

"Thus to differentiate the downstream effects of IKKbeta-p105-NFkappaBp50 and IKKbeta-p105-ERK pathways and further to demonstrate that the enhanced cytokine responses observed in the GRK2 Deltamye cells are mediated via these pathways, we examined LPS induced cytokine responses using pharmacological inhibitors of MEK-ERK (PD98059) and IKKbeta (BMS345541)."

20717897

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"Additionally, XD inhibited inflammatory response in LPS stimulated BEAS-2B cells possibly by blocking IKBKB and NF-kappaB signal pathway which was regulated by miR-15a."

29710526

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"IRAK1-/- macrophages display decreased LPS induced IKKbeta activation and NF-kappaB DNA binding."

25290089

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"The knockdown experiments using siRNAs for IKKbeta, IRF4, and/or IRF8 indicated that LPS induced upregulation of IL-10 and IL-6 was reduced in IKKbeta knocked-down cells, and that the upregulation of IL-12 was suppressed by the knockdown of IRF4 and IRF8."

28893954

Lipopolysaccharide affects CHUK

| 5

Lipopolysaccharide inhibits CHUK. 5 / 5

| 5

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"As shown in [XREF_FIG], LPS induces IKKalpha and beta phosphorylaton and treatment with KOTMIN13 strongly inhibits IKKalpha and beta phosphorylaton without affecting total IKK levels."

28539710

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reach

"LPS signals via the TLR-4 and CD14 complex and further downstream activates inhibitors of IkappaB Kinase (IKK)."

30080745

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➶

reach

"Moreover, LPS induced p-IKKalpha, p-IkappaBalpha, and p-NF-kappaB p65 levels were all suppressed by astaxanthin."

20932499

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"Western blot analysis showed that the level of IKK1 protein was not changed by incubation with polyphenols, suggesting that the inhibition of LPS induced IKK1 activity by the polyphenols was not due to decreased expression of IKK1.Because TF-3 was the most potent inhibitor of IKK in RAW 264.7 cells, we studied the effect of different concentrations of this polyphenol on IKK activity."

10644043

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"The most effective of the tested compounds was TF-3, which inhibited LPS induced IKK activity by about 80%, followed by geraniin, 5GG, EGCG, TF-1, and TF-2, whereas the inhibitory effects of TR, pyrocyanidin, and casuarinin on LPS induced IKK1 activity were rather low."

10644043

Imiquimod affects TLR7

| 5

Imiquimod inhibits TLR7. 5 / 5

| 5

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"If the induction of XPA gene expression is dependent on classical TLR signaling, we hypothesized that Bayer compound would block the up-regulation of XPA gene expression after TLR7 stimulation by imiquimod."

21765012

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➶

reach

"Reduced cell infiltration was observed in the bladder of TLR7 deficient mice treated with R-837 in poloxamer-HPbetaCD formulation similar to saline treated mice, indicating that inflammation induced by R-837 in the bladder was TLR7 dependent (XREF_FIG)."

20337728

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➶

reach

"Imiquimod mediated TLR7 activation induces secretion of proinflammatory cytokines, suppresses Tregs, and induces Th1 cell mediated activation of NK cells to eradicate cancer cells [XREF_BIBR]."

28116316

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reach

"Soluble Imiquimod Directly Inhibits the Growth of TLR7 - GL261 Glioma Cells."

21389872

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➶

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"Conversely, 100 nM TLR7 ligand significantly induced cell proliferation (XREF_FIG); however, the induction of proliferation was blocked by the addition of 100 microM Imiquimod, indicating that 100 microM Imiquimod effectively reversed the oncogenic function of the TLR7 ligand following 48 h of incubation (XREF_FIG)."

27123047

Hexadecanoic acid affects NFKBIA

| 5

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| 5

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"Subsequently, we observed that oleate was able to partially prevent IkappaB-alpha degradation induced by TNF-alpha or palmitate."

26055507

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➶

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"Myoblasts treated with palmitate exhibit activation of pathways leading to inflammation, specifically activating MAPK, elevating ROS and inducing IkappaBalpha degradation."

23078640

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"Additionally, the combination of palmitate and LPS also reduced IkBalpha at 60 min and IkBbeta in cytoplasm at 10 min."

30273577

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"The co-treatment with 400muM linoleate inhibited phospho-c-Jun N-terminal kinase (pJNK) activation and IkBalpha reduction caused by 500muM palmitate treatment."

24885871

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➶

reach

"It also has been shown to prevent palmitate induced IkappaBalpha degradation, RelA nuclear translocation, NO production, and cytokine secretion [XREF_BIBR], Besifloxacin is a novel fluoroquinolone initially developed by Bausch & Lomb for the topical treatment of ophthalmic infections [XREF_BIBR]."

29707159

Hemin affects NLRP3

| 5

Hemin inhibits NLRP3. 5 / 5

| 5

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"Likewise, in a sepsis induced ALI and ARDS murine model it has been shown that hemin inhibits NLRP3 inflammasome activation through the action of HO-1."

29868517

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➶

reach

"Supporting this hypothesis, a recent study showed that hemin inhibits NLRP3 inflammasome activation in a model of lung injury, through HO-1 activation [XREF_BIBR]."

29359167

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➶

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"Moreover, hemin reduced malondialdehyde and reactive oxygen species production, and inhibited NF-kappaB and NLRP3 inflammasome activity."

24583148

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➶

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"Our study suggests that hemin inhibited NLRP3 inflammasome activation involved HO-1, reducing IL-1beta and IL-18 secretion and limiting the inflammatory response."

24583148

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➶

reach

"In immunoprecipitation studies, hemin attenuated the interaction of NLRP3 with ASC and caspase-1."

23994575

Glucose affects MAPK8

| 4 1

Glucose inhibits MAPK8. 5 / 5

| 4 1

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➶

medscan

"Overexpression of JNK binding domain inhibited glucose deprivation-induced JNK1 activation, relocalization of Daxx from the nucleus to the cytoplasm, and apoptosis signal-regulating kinase 1 (ASK1) oligomerization in human prostate adenocarcinoma DU-145 cells. 45999999="domain"}"

12968034

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➶

medscan

"L-Buthionine-( S, R )-sulphoximine, which decreases intracellular glutathione content, enhanced glucose deprivation-induced activation of JNK1 by promoting the dissociation of TRX, but not glutaredoxin, from ASK1."

12723971

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➶

medscan

"We show that glucose deprivation induces the activation of c-jun NH(2)-terminal kinase (JNK)/stress-activated protein kinase in a mock transfectant but not in an ASNS transfectant."

17409444

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➶

medscan

"Similarly, cultured human islets exposed to high glucose- and leptin-induced caspase 1 and JNK inhibition prevented this up-regulation."

18263705

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"Treatment of HUVECs with media containing high glucose (4.5%) in the presence of 5-HMF (100, 200 and 400 muM) resulted in significant inhibition of high glucose induced oxidative stress and expression of JNK1 and JNK2/3."

23578643

Genistein affects JUN

| 5

Genistein inhibits JUN. 5 / 5

| 5

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"H7 (50 microM), genistein (2 microM) and okadaic acid (20 nM), all block the induction of c-jun and c-fos mRNA accumulation in the H2O2 treated rat lenses."

7835407

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"Western blotting demonstrated that the expressions of c-jun and c-fos protein were decreased gradually after being treated with 20 micromol/L genistein for 12 - 72 h. Genistein could down-regulate the expression of two key genes, c-erbB-2 and c-raf-1 at mRNA and protein level in the EGFR mediated signal transduction pathway, and down-regulate the expression of its downstream nuclear transcription factors c-jun and c-fos at mRNA and protein level."

15634453

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"In this study I found that biochanin, a methoxy form of genistein, inhibits IL-8-mediated activation of nuclear transcription factor kappaB (NF-kappaB) and activator protein 1 (AP-1) more potently than genistein as shown in Jurkat T-cell line."

22387535

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"Given that there is important crosstalk between AR and mitogen activated protein kinase (MAPK) signaling, we also investigated whether genistein activates the MAPK end targets c-Jun N-terminal kinase (JNK) and c-Jun."

18425381

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➶

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"Activator protein 1 activation in response to either high glucose or co-stimulation with high glucose and Ang II was inhibited completely by calphostin C (a PKC inhibitor) and partially by genistein (a protein tyrosine kinase inhibitor)."

11440364

Forskolin affects NLRP3

| 5

Forskolin inhibits NLRP3. 5 / 5

| 5

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"Forskolin treatment significantly decreased NLRP3 activation (XREF_FIG) and IL-1beta secretion (XREF_FIG), which was further decreased by adding PGE 2, suggesting additive PGE 2 -mediated mechanisms of adenylate cyclase activation."

25917098

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➶

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"Forskolin attenuates the NLRP3 inflammasome activation and IL-1beta secretion in human macrophages."

31086288

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➶

reach

"Forskolin attenuates the NLRP3 inflammasome activation and IL-1beta secretion in human macrophages."

31434103

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➶

reach

"Forskolin inhibits the NLRP3 inflammasome activation and the secretion of mature IL-1beta, in human macrophages."

31086288

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➶

reach

"We first made sure that the BOT-4-one action would not be influenced by PKA activation by observing that the PKA inhibitor H-89 could not prevent the BOT-4-one-mediated inhibition of NLRP3 inflammasome activation, whereas it restored the NLRP3 inflammasome functionality (maturation of IL-1beta and caspase-1) suppressed by the adenylyl cyclase activator forskolin."

29118366

Ethanol affects NFKBIA

| 5

Ethanol inhibits NFKBIA. 5 / 5

| 5

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"Studies exploring the potential mechanism by which ethanol suppresses endothelial cell activation revealed that ethanol blocked NF-kappaB nuclear entry in an IkappaBalpha dependent manner."

15528377

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➶

reach

"These results suggest that while acute alcohol induced IkappaBalpha degradation could be independent of IKK kinase, chronic alcohol induced IkappaBalpha degradation is dependent on IKK kinase activity."

19561104

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➶

reach

"In contrast, ethanol inhibited the KA- but not the QA induced degradation of IkappaB-alpha and the ensuing DNA fragmentation and loss of striatal GABAergic neurons."

10719066

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➶

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"EtOH degrades I-kappaBalpha, distributes NF-kappaB to the cell nucleus, and activates NF-kappaB protein subunits."

17869053

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➶

reach

"These new data suggest that inhibition of alcohol inducible degradation of IKB-alpha by TPKC can prevent much of the adverse microvascular actions of ethanol in the intact rat brain."

12431766

Dimethyl sulfide affects NLRP3

| 5

Dimethyl sulfide inhibits NLRP3. 5 / 5

| 5

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"To confirm whether or not MSM and DMSO inhibit NLRP3 inflammasome activation via mitochondrial ROS generation, we firstly confirmed the effect of DPI, an inhibitor of cytosolic and mitochondrial ROS production [23], on NLRP3 inflammasome activation."

25461402

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➶

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"Thus, MSM as well as DMSO inhibited NLRP3 inflammasome activation by blocking mitochondrial ROS generation.In this study, we confirmed MSM as a selective NLRP3 inflammasome inhibitor."

25461402

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➶

reach

"We further confirmed that MSM attenuated NLRP3 inflammasome activation through inhibition of mitochondrial ROS production, similar to DMSO."

25461402

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➶

reach

"In our results, MSM significantly attenuated NLRP3 inflammasome activation in lipopolysaccharide primed macrophages, although it had no effect on NLCR4 or AIM2 inflammasome activation."

25461402

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➶

reach

"Thus, MSM not only blocked the NLRP3 inflammasome at the activation step but also down-regulated pro-IL-1beta and NLRP3 expression at the priming step.MSM is a form of organic nutritional sulfur found in dairy products such as fruits, grains, meats, and vegetables."

25461402

Dapagliflozin affects NLRP3

| 5

Dapagliflozin inhibits NLRP3. 5 / 5

| 5

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"Ticagrelor, a P2Y12 receptor antagonist, and dapagliflozin, a sodium-glucose-cotransporter-2 inhibitor, suppress the activation of the NLRP3 inflammasome."

32335797

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➶

reach

"These results suggested that dapagliflozin can reduce the ROS production and NLRP3 inflammasome activation in aortic root of the DM mice."

28104929

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reach

"Results of our study indicated that SGLT2 inhibitors dapagliflozin can attenuate the formation of atherosclerotic lesion and increase the stability of lesion by inhibiting the NLRP3 inflammasome in diabetic atherosclerosis, which provide further evidence for its benefits in DM patients"

28104929

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➶

reach

"Both dapagliflozin and ticagrelor attenuated the progression of diabetic cardiomyopathy, the activation of the NLRP3 inflammasome, and fibrosis in BTBR mice with additive effects of the combination."

32335797

---

➶

reach

"Interestingly, inhibition of the NLRP3 pathway was not observed in isolated macrophages treated with dapagliflozin."

29515457

Cyclosporin A affects ITCH

| 5

Cyclosporin A inhibits ITCH. 5 / 5

| 5

---

➶

reach

"Intraperitoneal injection of cyclosporine A dose-dependently inhibited increased itch related receptor gene expression, such as interleukin-31 receptor A and neurokinin-1 receptor, in the dorsal root ganglion of atopic dermatitis model mice."

26671728

---

➶

reach

"A case series from Hong Kong [XREF_BIBR] comprising 14 children with AC, VKC, AKC with mean age 10.8 +/- 3.2 years showed that topical CsA 0.05% Restasis reduced symptoms, signs, and itch severity scores compared with baseline (p < = 0.001) and 78.6% of subjects successfully tapered off steroid eye drops."

28487836

---

➶

reach

"By using this system we have found that itch in atopic dermatitis is not inhibited by antihistamines but by cyclosporin A, a drug inhibiting cytokine production."

1419979

---

➶

reach

"Cyclosporin A significantly reduced the itch intensity, the eczema score and the consumption of topical hydrocortisone."

1977258

---

➶

reach

"Supporting this theory is the finding that ciclosporin A, an inhibitor of lymphokine production, reduces itch in atopic dermatitis."

1575979

Curcumin affects CASP1

| 1 4

Curcumin inhibits CASP1. 5 / 5

| 1 4

---

➶

eidos

"Yin et al. showed that curcumin inhibited caspase-1 activation and IL-1beta secretion through suppressing lipopolysaccharide ( LPS ) priming and NLRP3 inflammasome in mouse bone marrow-derived macrophages , and confirmed these results in vivo in a model of high-fat diet-induced insulin resistance in wild-type C57BL / 6 mice [ 72 ] ."

32326376

---

➶

reach

"Silencing of NLRP3 or ASC by siRNA did not inhibit curcumin induced caspase-1 activation in mouse MM cells."

24431405

---

➶

reach

"We report that curcumin inhibited caspase-1 activation and IL-1beta secretion through suppressing LPS priming and the inflammasome activation pathway in mouse bone marrow derived macrophages."

29549176

---

➶

reach

"As a result from suppression of ER stress associated TXNIP induction, curcumin inhibited NLRP3 and caspase-1 activation, and thereby reduced IL-1beta secretion."

25791922

---

➶

reach

"Curcumin suppressed the upregulation of NLRP3, caspase-1, pro-IL-1beta and IL-1beta proteins (XREF_FIG), the increased ratio of caspase-1 to procaspase-1 and IL-1beta to pro-IL-1beta (XREF_FIG), as well as the enhanced caspase-1 activity (XREF_SUPPLEMENTARY), but had no significant effect on procaspase-1 expression (XREF_FIG) in SHR derived VSMCs."

28981106

Capsaicin affects JUN

| 2 3

Capsaicin inhibits JUN. 5 / 5

| 2 3

---

➶

reach

"Han et al. showed in a study published in 2002 that topical application of capsaicin on the skin of female ICR mice suppresses phorbol ester induced activation of nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1) and concluded that this might be responsible for the chemopreventive effects of capsaicin [XREF_BIBR]."

29258175

---

➶

reach

"Furthermore, capsaicin significantly reduced palmitate stimulated activation of c-Jun N-terminal kinase, c-Jun, and p38."

21745629

---

➶

reach

"In fact, we found in this study that capsaicin inhibits c-jun induction, stimulated by MNNG, in the spleen, heart, stomach and lung."

10463771

---

➶

medscan

"Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells."

21745629

---

➶

medscan

"Furthermore, capsaicin significantly reduced palmitate-stimulated activation of c-Jun N-terminal kinase, c-Jun, and p38."

21745629

Calcium(2+) affects NFKBIA

| 5

Calcium(2+) inhibits NFKBIA. 5 / 5

| 5

---

➶

reach

"The purpose of the present study was to test the hypothesis that TNF-alpha-induced dysregulation of [Ca (2+)] (i) in insulin producing beta-cells causes proteolytic degradation of IkappaBalpha and consequently leads to the transcriptional activation of nuclear factor-kappaB (NF-kappaB)."

21494319

---

➶

reach

"We show here that IL-3 induces a SFK- and Ca 2+ -dependent activation of the inhibitor of kappaB kinases 2 (IKK2) which results in mast cell proliferation and survival but does not induce IkappaBalpha degradation and NFkappaB activation."

25749030

---

➶

reach

"The Ca 2+ chelator BAPTA-AM markedly suppressed nuclear accumulation of IkappaBalpha and its degradation."

20797629

---

➶

reach

"All tested IkappaBalpha targets (n = 12) were robustly induced by TNFalpha treatment (up to 12-fold) following different kinetics (XREF_FIG) and to a lesser extent (up to 3-fold) by Ca 2+ treatment (XREF_SUPPLEMENTARY) or IkappaBalpha KD (XREF_SUPPLEMENTARY)."

23850221

---

➶

reach

"[Ca 2+] i increase is considered to mediate the degradation of IkappaB-alpha and the subsequent activation of NF-kappaB XREF_BIBR, XREF_BIBR."

23805318

Calcium(2+) affects FOS

| 5

Calcium(2+) inhibits FOS. 5 / 5

| 5

---

➶

reach

"Removal of extracellular calcium attenuated induction of hsp70 mRNA but not the induction of c-fos or c-myc."

8636412

---

➶

reach

"Taken together, our data indicate that Fas and FasL upregulation in AA treated U937 cells is elicited by Ca (2+)/ROS-mediated suppression of ERK and c-Fos pathway and activation of p38 MAPK/ATF-2, and suggest that autocrine Fas mediated apoptotoic mechanism is involved in AA induced cell death."

19720122

---

➶

reach

"Taken together, our data indicate that MMP-2 and MMP-9 down-regulation in caffeine treated U937 cells is elicited by Ca (2+)/ROS-mediated suppression of ERK and c-Fos pathway and activation of p38 MAPK and c-Jun pathway."

20432471

---

➶

reach

"The calcium chelator BAPTA-AM inhibits the shear-induction, as well as the static level, of c-fos activity."

12659853

---

➶

reach

"However, calpains are unable to complete c-Fos degradation (i.e. degradation intermediates accumulate) and, as discussed by the authors [24], the calcium levels used to degrade c-Fos by calpains are high above the normal calcium levels found within cells F. Aniento et al./FEBS Letters 390 (1996) 47 52 51 A = E " 6 o : = Z (.3 o B 123456 C Trypsin TX-IO0 -."

8706827

Calcium(2+) affects CASP1

| 1 4

Calcium(2+) inhibits CASP1. 5 / 5

| 1 4

---

➶

reach

"In addition, our experiments showed that the Ca 2+ chelator, BAPTA-AM, did not completely inhibit caspase-1 activation and mitochondrial ROS production."

28012441

---

➶

reach

"Treatment with 1, 2-bis (2-aminophenoxy) ethane-N, N, N ', N '-tetraacetic acid acetoxymethyl ester, a chelator of intracellular calcium, inhibited IL-32-induced IL-1 beta production and caspase-1 activation."

21147537

---

➶

reach

"The lotr1 mutants display altered localization of CASP1, an essential protein for Casparian strip formation [9], disrupted Casparian strips, ectopic suberization of endodermal cells, and low accumulation of shoot calcium (Ca)."

28238658

---

➶

medscan

"Calcium removal blocks caspase-1 activation."

25048991

---

➶

reach

"Both ACA, a channel blocker that acts on several transient receptor potential (TRP) channels including TRPM2, and 3MFA, a TRPM2 specifical inhibitor [53,54], significantly suppressed Ca 2+ influx in UCN stimulated BMDMs and also inhibited UCN elicited caspase 1 activation and IL-1beta secretion."

27632706

Berberine affects NLRP3

| 5

Berberine inhibits NLRP3. 5 / 5

| 5

---

➶

reach

"Berberine suppresses influenza virus triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS."

32272506

---

➶

reach

"Berberine inhibits NLRP3 Inflammasome pathway in human triple negative breast cancer MDA-MB-231 cell."

31412862

---

➶

reach

"Berberine Attenuates NLRP3 Inflammasome Activation in Macrophages to Reduce the Secretion of Interleukin-1beta."

29263046

---

➶

reach

"Berberine inhibited hepatic necroinflammation, IL-1beta, and NLRP3 inflammasome in non alcoholic steatohepatitis (NASH) induced by methionine and choline - deficient diet in mouse, which based on interference with activation of P2x7, a purinergic receptor involved in inflammasome activation."

29922155

---

➶

reach

"The alkaloids, berberine and ligustrazine, were found to inhibit the NLRP3 inflammasome."

29922155

Barium(2+) affects NFKBIA

| 5

Barium(2+) inhibits NFKBIA. 5 / 5

| 5

---

➶

reach

"IKBa demonstrated strong inward rectification and was inhibited by Ba (2+) in a dose- and voltage dependent fashion, with the K (d) decreasing with hyperpolarization."

17091215

---

➶

reach

"BA further increased phospho-IkappaBalpha and phospho-p65 and decreased total IkappaBalpha compared to 2ME2 or Doc alone in LN-AI and DU145 cells, suggesting enhancement of NF-kappaB activity."

20618955

---

➶

reach

"Both BA forms induced IkappaBalpha degradation, indicative of NF-kappaB activation, to comparable extents (XREF_FIG)."

28400473

---

➶

reach

"BA also downregulated the transcription of vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGF-beta) and decreased the expression of the NF-kB pathway proteins (NF-kB-P65, IkBalpha, and IKKalpha and beta) in the TNF-alpha-stimulated RA-FLS."

32718263

---

➶

reach

"BA suppressed the activation of IkappaBalpha kinase, thus abrogating the phosphorylation and degradation of IkappaBalpha."

12960358

Baicalin affects MYD88

| 5

Baicalin inhibits MYD88. 5 / 5

| 5

---

➶

reach

"Baicalin down-regulated the TLR2/4, MyD88, and NF-kappaB signaling, and inhibited subsequent proinflammatory responses."

24417870

---

➶

reach

"In RAW264.7 cells with CD14 knockdown, baicalin pretreatment did not prevent inflammatory responses and activation of MyD88 and NF-kappaB p65 pathway induced by high concentrations (1000mug/mL) of LPS."

32457419

---

➶

reach

"Wan and colleagues [XREF_BIBR] demonstrated that baicalin inhibits TLR7 and MYD88 signaling pathway activation to suppress lung inflammation in mice infected with influenza A virus."

29849712

---

➶

reach

"In conclusion, baicalin effectively reduced the pathological damage and inflammation of the lungs by downregulating the TLR7 and MYD88 mediated signaling pathway."

24748990

---

➶

reach

"Baicalin inhibits TLR7 and MYD88 signaling pathway activation to suppress lung inflammation in mice infected with influenza A virus."

24748990

Apigenin affects CHUK

| 5

Apigenin inhibits CHUK. 5 / 5

| 5

---

➶

reach

"Given the role for IKKalpha mediated NF-kB signaling in tumorigenesis and the IKKalpha activation in prostate cancer we provide in vitro experimental evidence that apigenin specifically binds with IKKalpha with higher affinity than IKKbeta and blocks IKKalpha activation, which correlated with reduced migration of cancer cells treated with apigenin."

26435478

---

➶

reach

"Apigenin blocks IKKalpha activation and suppresses prostate cancer progression."

26435478

---

➶

reach

"Further research work is needed to investigate how apigenin mediated IKKalpha inhibition affects downstream mechanisms involved in the process of metastasis."

26435478

---

➶

reach

"In this study, we present several lines of evidence that IKKalpha plays an important role in cancer progression and that apigenin specifically blocks IKKalpha activation, leading to decreased proliferation and enhanced apoptosis in prostate cancer cells."

26435478

---

➶

reach

"Apigenin blocks catalytic site of IKKalpha and IKKbeta-In silico molecular modeling."

26435478

Adenosine affects STAT1

| 5

Adenosine inhibits STAT1. 5 / 5

| 5

---

➶

reach

"We observed similar inhibition of STAT1 S727 phosphorylation in cells treated with A 1, A 2A, and A 2B receptor specific antagonists (CPX, SCH 58261, and alloxazine, respectively), suggesting that these three receptor subtypes do not play an important role in adenosine mediated STAT1 deactivation (XREF_FIG)."

19846878

---

➶

reach

"Our data suggest that adenosine blocks IFN-gamma-induced STAT1 transcriptional activity, providing a functional correlate for its effect on phosphorylation of STAT1 at S727."

19846878

---

➶

reach

"These data confirm that STAT1 DNA binding ability is not disrupted by adenosine treatment."

19846878

---

➶

reach

"In contrast, we show that adenosine treatment both delays STAT1 responsive promoter activity and markedly attenuates the maximal STAT1 activity in IFN-gamma-stimulated macrophages, providing a functional correlate to the reduction in STAT1 S727 phosphorylation observed in adenosine treated cells."

19846878

---

➶

reach

"Furthermore, these results suggest that adenosine does not impede STAT1 dimerization because only the stable dimer is capable of subcellular localization to the nucleus and binding DNA."

19846878

Acetylsalicylic acid affects NFKBIA

| 1 4

Acetylsalicylic acid inhibits NFKBIA. 5 / 5

| 1 4

---

➶

medscan

"Gao et al. ( ) demonstrated that aspirin treatment prevents IκBα degradation in human muscle and a decrease in IκBα in human skeletal muscle is associated with fatty acid-induced insulin resistance ( )."

19798070

---

➶

reach

"We found that aspirin treatment induced degradation of IkappaBalpha in a similar concentration dependent manner in each cell line genotype (XREF_FIG)."

15770215

---

➶

reach

"Furthermore, inhibition of c-Src activity, by chemical inhibition or expression of a kinase dead form of the protein abrogates aspirin mediated degradation of IkappaBalpha, nuclear translocation of RelA and apoptosis, suggesting a causal link."

21551129

---

➶

reach

"Our previous work demonstrated that aspirin induces time- and dose dependent signal specific degradation of IkappaBalpha, nuclear translocation of NFkappaB and apoptosis in CRC cells."

15188000

---

➶

reach

"We also demonstrated that aspirin induced IkappaBalpha degradation was required for apoptosis because cells constitutively expressing super-repressor IkappaBalpha were resistant to both aspirin induced NFkappaB nuclear translocation and apoptosis."

15770215

Acetylsalicylic acid affects JUN

| 3 2

Acetylsalicylic acid inhibits JUN. 5 / 5

| 3 2

---

➶

medscan

"Here, we also show that acetylsalicylic acid inhibits JNK activation, c-Jun phosphorylation, and cardiac fibroblasts migration, demonstrating that acetylsalicylic acid inhibits two major signal transduction pathways in cardiac fibroblasts that are oxidative stress-responsive."

24265116

---

➶

medscan

"These results indicate that acetylsalicylic acid inhibits p65 and c-Jun activation by targeting their upstream regulators IKKb and JNK in cardiac fibroblasts ( )."

24265116

---

➶

medscan

"We have demonstrated that acetylsalicylic acid inhibits IL-18-induced p65 or c-jun activation in cardiac fibroblasts."

24265116

---

➶

reach

"Moreover, aspirin has been reported to inhibit the functionality of NF-kappaB or activator protein-1 (AP-1) which are associated with increased production of ROS [XREF_BIBR]."

28286779

---

➶

reach

"It was also recently reported that sodium salicylate and aspirin suppressed the activation of activator protein-1 in mouse epidermal cells exposed to UVB light [21]."

10594377

U50488 affects ITCH

| 1 4

U50488 inhibits ITCH. 5 / 5

| 1 4

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➶

reach

"Thus, it is possible that U-50,488 H decreases the activity of histamine sensitive itch specific neurons in the dorsal horn of the spinal cord and thereby restores their ability to inhibit itch."

11334876

---

➶

reach

"U-50,488 also attenuated chronic itch induced by 2,4-dinitrofluorobenzene (DNFB), a model for allergic contact dermatitis (ACD), and in mice with dry skin itch induced by an acetone-ether-water (AEW) treatment."

29669290

---

➶

reach

"To test whether U-50,488 may inhibit CQ itch via GRPR independent pathway, we examined its effect on CQ itch using Grpr KO mice and found that i.t. U-50,488 did not further reduce CQ induced scratching (XREF_SUPPLEMENTARY)."

29669290

---

➶

reach

"However, U-50,488 attenuated CQ induced itch after siRNA knockdown of Prkca, suggesting that PKCalpha does not mediate KOR activation inhibition of itch (XREF_SUPPLEMENTARY)."

29669290

---

➶

sparser

"To test whether U-50,488 may inhibit CQ itch via GRPR-independent pathway, we examined its effect on CQ itch using Grpr KO mice and found that i."

29669290

U0126 affects NLRP3

| 5

U0126 inhibits NLRP3. 5 / 5

| 5

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➶

reach

"By inhibiting ERK and NF-kappaB, U0126 and BAY 117082 inhibited mir-21 over-expression-induced activation of the NLRP3 inflammasome complex."

29084974

---

➶

reach

"By inhibiting ERK and NF-κB, U0126 and BAY 117082 inhibited mir-21 over-expression-induced activation of the NLRP3 inflammasome complex."

29084974

---

➶

reach

"Moreover, we found that the overexpression of miR-155 promoted the activation of the ox-LDL-induced NLRP3 inflammasome, which could also be blocked by the ERK inhibitor U0126."

31865729

---

➶

reach

"U0126 or BAY, inhibitor of ERK or NF-kappaB, inhibited activation of NLRP3 inflammasome complex induced by mir-21 overexpression."

27502441

---

➶

reach

"In shScr BMDMs, LPS priming increased mitochondrial distribution of NLRP3, which is inhibited by U0126 (XREF_FIG)."

26489382

Sunitinib affects JAK1

5 |

Sunitinib inhibits JAK1. 5 / 5

5 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

18077425

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

15711537

SUNITINIB MALATE affects JAK1

5 |

SUNITINIB MALATE inhibits JAK1. 5 / 5

5 |

---

➶

tas

No evidence text available

15711537

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

18077425

SB 203580 affects NFKBIA

| 1 4

SB 203580 inhibits NFKBIA. 5 / 5

| 1 4

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➶

reach

"To establish a role of p38 in IkappaB-alpha degradation, C6 cells were treated with 10 muM SB203580 for 1 h and then co-treated with SB203580, 100 ng/mL TNF-alpha and 50 ng/mL IL-1beta."

18679050

---

➶

reach

"However, salusin-beta treatment resulted in the obvious up-regulation of NF-kappaBp65 and down-regulation of I-kappaBalpha (P < 0.05, P < 0.01, XREF_FIG), which was antagonized by SB203580 and SP600125 (P < 0.05, P < 0.01)."

25210730

---

➶

medscan

"The p38 mitogen-activated protein kinase inhibitor SB203580 prevented stabilization of IkappaBalpha and delayed the re-emergence of IkappaBalpha following TNF-alpha-induced degradation."

12704657

---

➶

reach

"The p38 mitogen activated protein (MAP) kinase inhibitor SB203580 prevented stabilization of IkappaBalpha and delayed the re-emergence of IkappaBalpha following TNF-alpha-induced degradation."

12704657

---

➶

reach

"Microinjection of p38 inhibitor SB203580 into the NAc prior to the application of morphine prevented the acquisition of CPP and inhibited the activation of p38, IkappaB-alpha and NF-kappaB p65."

21130118

SB 203580 affects MAPK8

| 2 3

SB 203580 inhibits MAPK8. 5 / 5

| 2 3

---

➶

medscan

"Inhibition of c-jun N-terminal kinase (JNK) by SP600125, p38 by SB 203580, or tyrosine kinase by genistein reduced arecoline-induced Hemeoxygenase-1 expression."

21889036

---

➶

medscan

"Our data showed that extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059, but not the c-Jun N-terminal kinase (JNK) inhibitor SP600125, p38 kinase inhibitor SB203580, and PI3K inhibitor wortmannin, attenuated Src-induced MMP-2 promoter activity."

16453304

---

➶

reach

"Further experiments showed that SB203580 was not able to suppress the mobility shift in Jnk1 and Jnk2 single knockout cells, indicating that both Jnk kinases act redundantly to phosphorylate B-Myb (XREF_SUPPLEMENTARY)."

23449447

---

➶

reach

"To test that SB203580 was not inhibiting JNK1 activity as well, we measured JNK1 activity and found that SB203580 had little effect on drug induced JNK1 activation."

11734304

---

➶

reach

"The SAP kinases SAPK1 gamma and JNK1, SAPK3 and SAPK4 are not inhibited by SB 203580, because they have methionine in the position equivalent to Thr106 in the ATP binding region of SAPK2a and p38 and SAPK2b and p38 beta 2."

9653550

SB 203580 affects JUN

| 1 1 3

SB 203580 inhibits JUN. 5 / 5

| 1 1 3

---

➶

sparser

"LPS activation of nuclear factor-kappa B (NF-kappaB), activator protein-1 (AP-1) and p38 MAPK was also inhibited by SB 203580."

10447723

---

➶

reach

"SB203580 treatment alone, in the absence of db-cAMP, was not sufficient to induce the myelin associated proteins or down-regulate c-Jun (data not shown)."

22623660

---

➶

reach

"p38 activity can be completely inhibited without effect on c-Jun phosphorylation, whereas 10 micrometer SB203580 strongly inhibits neuronal JNK2/3, stress induced c-Jun phosphorylation, induced c-Jun activity, and neuronal death in response to trophic withdrawal stress."

12040039

---

➶

reach

"Moreover, the present study showed that IL-17A induced the nuclear translocation of c-Jun and c-Fos, which could be effectively inhibited by the JNK inhibitor SP600125 or the p38 inhibitor SB203580."

26988982

---

➶

medscan

"TNF-α-mediated AP-1-luciferase activity and c-Jun binding to the AP-1 element were inhibited by TNFR1 antibody, thioredoxin, SP600125, and SB203580."

22711527

PH 797804 affects MAPK14

1 4 |

PH 797804 inhibits MAPK14. 5 / 5

1 4 |

---

➶

signor

No evidence text available

Other

---

➶

tas

No evidence text available

19950901

---

➶

tas

No evidence text available

21620699

---

➶

tas

No evidence text available

21641211

---

➶

tas

No evidence text available

20395140

N-methyl-D-aspartic acid affects FOS

| 5

N-methyl-D-aspartic acid inhibits FOS. 5 / 5

| 5

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➶

reach

"The N-methyl-D-aspartate (NMDA) antagonist, MK-801 (4 mg/kg, i.p.) inhibited c-fos and junB mRNA induction in the cortex, striatum, thalamus, and hippocampus but not in the substantia nigra."

7845604

---

➶

reach

"The non competitive N-methyl-D-aspartate antagonists ketamine (100 mg/kg, i.p.) and MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5,10-imine maleate] (1 and 3 mg/kg, i.p.) markedly reduced c-fos activation."

2166242

---

➶

reach

"Like the competitive antagonists, intrastriatal infusion of the non competitive NMDA antagonist MK-801 partially decreased c-fos, but not zif268, mRNA in the area around the microdialysis probe."

8708002

---

➶

reach

"The N-methyl-D-aspartate (NMDA) antagonist, MK-801 (4 mg/kg, i.p.) inhibited c-fos and junB mRNA induction in the cortex, striatum, thalamus, and hippocampus but not in the substantia nigra."

7845604

---

➶

reach

"NMDA preconditioning and neuroprotection in vivo : delayed onset of kainic acid induced neurodegeneration and c-Fos attenuation in CA3a neurons."

19118538

N-acetyl-L-cysteine affects NLRP3

| 5

N-acetyl-L-cysteine inhibits NLRP3. 5 / 5

| 5

---

➶

reach

"The use of ROS scavenger N-acetylcysteine (NAC) partially reversed NLRP3 inflammasome activity in cells exposed to burn serum."

26576075

---

➶

reach

"In high glucose cultured cardiomyocytes, Klotho and N-acetylcysteine significantly downregulated intracellular reactive oxygen species generation and TXNIP and NLRP3 inflammasome activation."

31422095

---

➶

reach

"Moreover, ROS was required for E. coli O157 : H7 induced NLRP3 assembly as inhibiting mitochondrial ROS release by ROS scavengers Mito-TEMPO and N-acetylcysteine abrogated NLRP3 inflammasome activation in Caco-2 cells in response to E. coli O157 : H7."

28476502

---

➶

reach

"Additionally, we also observed that N-Acetylcysteine (NAC, a ROS scavenger) pretreatment inhibited NLRP3 inflammasome activation as evidenced by suppressing the upregulation of NLRP3, ASC, cleaved-caspase-1, GSDMD-N, IL-1beta and IL-18 protein levels in CSE treated ECs."

31521245

---

➶

reach

"We reported previously that high glucose and lipopolysaccharide activate ROS-TXNIP-NLRP3 inflammasome signaling in GMCs, but ROS inhibitor N-acetylcysteine (NAC) could not completely inhibit the activation of NLRP3 inflammasome induced by high glucose, suggesting that there may be other pathways by which high glucose primes ROS-NLRP3 inflammasome signaling [XREF_BIBR]."

29675433

N-acetyl-L-cysteine affects NFKB1

2 | 3

N-acetyl-L-cysteine inhibits NFKB1. 5 / 5

2 | 3

---

➶

ctd

No evidence text available

10661865

---

➶

reach

"N-acetylcysteine can also downregulate NFkB, with resultant reduction in neutrophil chemoattractant messenger RNA (mRNA) and alveolitis in a rat model of lung injury.Vitamin C and E administration in the critically ill reduced duration of mechanical ventilation and ICU stay without decreasing the incidence of ARDS.101Statins were introduced into clinical practice as cholesterol-lowering agents through inhibition of HMG-CoA reductase and have since been shown to possess pleiotropic actions both dependent and independent of HMG-CoA reductase inhibition."

| PMC

---

➶

ctd

No evidence text available

18922898

---

➶

reach

"N-Acetylcysteine also has been shown to inhibit NFKB activation by several stimuli including ILl, phorbol myristate acetate, TNF and lipopolysaccaride [16,15]."

7841193

---

➶

reach

"N-acetylcysteine can also downregulate NFkB, with resultant reduction in neutrophil chemoattractant messenger RNA (mRNA) and alveolitis in a rat model of lung injury."

| PMC

N-acetyl-L-cysteine affects JUN

2 | 3

N-acetyl-L-cysteine inhibits JUN. 5 / 5

2 | 3

---

➶

ctd

No evidence text available

17696279

---

➶

medscan

"The antioxidants, N-acetylcysteine and glutathione, but not vitamin C or tiron, inhibited perifosine-induced elevation of p-c-Jun, DR4 and DR5."

21172010

---

➶

ctd

No evidence text available

8797811

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➶

medscan

"Our data indicate that N-acetylcysteine, a well-known antioxidant, effectively prevents ultraviolet irradiation/reactive oxygen species induction of c-Jun and its downstream effector cysteine-rich protein 61."

25536346

---

➶

medscan

"Furthermore, CSE-induced p300 and c-Jun complex formation was inhibited by pretreatment with diphenyleneiodonium chloride, apocynin, N-acetyl-L-cysteine or SP600125."

21268080

N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide affects IKBKE

1 1 | 3

N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide inhibits IKBKE. 5 / 5

1 1 | 3

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➶

reach

"Interestingly BX795, a molecule which inhibits TBK1 and IKKepsilon, has recently been shown to inhibit IFN-I production and signaling in human PBMCs with a mutation induced interferonopathy [8]."

29673738

---

➶

signor

No evidence text available

Other

---

➶

reach

"Moreover, GM-DCs in which TBK1 and IKKepsilon were inhibited by BX795 showed substantial impairment in the phosphorylation of Akt at Ser473 and Thr308 and of PRAS40 and the ribosomal protein S6, and this was more profound than the inhibition observed after inhibition of PI (3) K or mTOR (XREF_FIG and XREF_SUPPLEMENTARY)."

24562310

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➶

tas

No evidence text available

---

➶

reach

"BX795 [originally developed as a 3phosphoinositidedependent protein kinase 1 (PDK1)] [90] and a series of azabenzimidazole derivatives [91] inhibit both IKKe and TBK1 at low nanomolar concentrations [92] ."

23395611

N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide affects IFNB1

| 5

N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide inhibits IFNB1. 5 / 5

| 5

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➶

reach

"In addition, BX795 inhibited the production of IFN-beta and TNF-alpha in DCs induced by DeltaN146 and LPS (XREF_FIG)."

28150813

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➶

reach

"Further analysis showed that BX795 effectively inhibited the induction of IFN-beta by DeltaN146 as measured by qRT-PCR (XREF_FIG)."

28150813

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➶

reach

"And the results of ELISA and western blot confirmed that BX795 and resveratrol were able to effectively inhibit the production of IFN-beta and inflammatory cytokines, respectively."

29050325

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➶

reach

"By contrast, BX795 significantly inhibited IFN-alpha and IFN-beta secretion but did not significantly affect the production of TNF-alpha, IL-6, MCP-1 and CXCL10."

26776505

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➶

reach

"We also recently reported that a BX795 treatment successfully inhibited IFN-beta production that was stimulated by the cytoplasmic delivery of cyclic di-GMP, an agonist for the DDX41 mediated STING-TBK1-IRF3 pathway in Raw 267.4 macrophage cells."

25605799

N-[3-[[5-cyclopropyl-2-[3-(4-morpholinylmethyl)anilino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide affects IKBKE

1 | 4

N-[3-[[5-cyclopropyl-2-[3-(4-morpholinylmethyl)anilino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide inhibits IKBKE. 5 / 5

1 | 4

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➶

reach

"In addition, the MRC PPU International Centre for Kinase Profiling reported in vitro specificity screens for several inhibitors (http://www.kinase-screen.mrc.ac.uk/kinase-inhibitors), showing that MRT67307 not only inhibits IKKepsilon and TBK1 and the AMPK related kinases MARK, MELK and NUAK, but also Mixed Lineage Kinase (MLK) 1 and MLK3, Janus kinase (JAK) 2, and Ca (2+)/calmodulin-dependent protein kinase kinase beta (CamKKbeta)."

29755980

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➶

reach

"The IKKepsilon and TBK1 inhibitor MRT67307 inhibits CYLD phosphorylation independent of IKKepsilon and TBK1."

29755980

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➶

reach

"As it was shown previously that MRT67307 can inhibit IKKepsilon and TBK1 at concentrations as low as 1-2 muM, the concentration of 10 muM used may have led to off-target effects."

29755980

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➶

reach

"MRT67307 specifically inhibits the IKKepsilon and TBK1 kinases, which are involved in controlling the production of Type1 interferons but also participate in a negative regulatory loop that restricts the extent of activation of the IKK complex [XREF_BIBR] [XREF_BIBR]."

29958295

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➶

tas

No evidence text available

Leu-Thr affects CASP1

| 5

Leu-Thr inhibits CASP1. 5 / 5

| 5

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➶

reach

"The heat shock inhibition of LT mediated caspase-1 activation was not specific to the Nalp1b (NLRP1b) inflammasome, as heat shock also inhibited Nalp3 (NLRP3) inflammasome mediated caspase-1 activation in macrophages."

18671821

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➶

reach

"In this study, we found that heat shock can rapidly prevent anthrax LT induced macrophage death by inhibiting caspase-1 activation, an event known to be required for cell death from LT."

18671821

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➶

reach

"However, the heat shock inhibition of LT mediated caspase-1 activation was not specific to the Nalp1b (NLRP1b) inflammasome, as heat shock also inhibited Nalp3 (NLRP3) inflammasome mediated caspase-1 activation in macrophages."

18671821

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➶

reach

"Proteasome inhibitors block LT mediated caspase-1 activation and can protect against cell death, indicating that the degradation of at least one cellular protein is required for LT mediated cell death."

18266992

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➶

reach

"Loss of NALP1b or caspase-1 provided protection against LT induced cell death in LT sensitive macrophages, suggesting that LT induces caspase-1 dependent cell death."

19154716

L 709049 affects CASP1

5 |

L 709049 inhibits CASP1. 5 / 5

5 |

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➶

ctd

No evidence text available

9570801

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➶

ctd

No evidence text available

29960001

---

➶

ctd

No evidence text available

16927020

---

➶

ctd

No evidence text available

27689324

---

➶

ctd

No evidence text available

31070765

BI-2536 affects IFNB1

| 5

BI-2536 inhibits IFNB1. 5 / 5

| 5

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➶

reach

"Since BI-2536 and JQ1 blocked IFNbeta production by preventing the interaction of transcription factors with the Ifnb promoter, it was of interest to examine the effects of these compounds on the transcription of other poly (I : C) - and LPS regulated genes."

25891802

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➶

reach

"BI-2536 blocks Ifnb mRNA production without affecting the phosphorylation, dimerization or nuclear translocation of IRF3."

25891802

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➶

reach

"It was therefore surprising when BI-2536 and some other PLK inhibitors were reported to suppress the production of Ifnb mRNA and the transcription of some ISGs in primary BMDCs (bone-marrow-derived dendritic cells) stimulated with the dsRNA-mimetic poly (I : C) or LPS, or infected with VSV (vesicular stomatitis virus)."

25891802

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➶

reach

"Similar to the TLR3-TBK1-IRF3 pathway, we found that BI-2536, JQ1 and I-BET151 blocked the TLR7- or TLR9 stimulated secretion of IFNbeta in Gen2.2 cells (XREF_FIG A and XREF_FIG B), without affecting the TLR stimulated translocation of the endogenous IRF5 to the nucleus (XREF_FIG C)."

25891802

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➶

reach

"We confirmed earlier observations that BI-2536 prevents the LPS stimulated secretion of IFNbeta when included in the cell culture medium at a concentration of 1.0 muM or higher."

25891802

Arg-Val affects STAT1

| 5

Arg-Val inhibits STAT1. 5 / 5

| 5

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➶

reach

"RV has also been shown to inhibit the function of STAT1 and STAT2 by an unknown mechanism and thus, can potentially inhibit all types of IFN responses [XREF_BIBR]."

22677178

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➶

reach

"Although viral factors responsible for this inhibitory effect downstream of STAT1 activation have not yet been identified, it is possible that redundancy in RV inhibition of the STAT1 pathway exists, perhaps indicative of the vital role of inhibiting IFN signaling in enabling RV replication.The ability of the RV NSP1 protein to target IRFs for proteasomal degradation extends to IRF7 and IRF9, two additional factors that are critical for the optimal amplification of IFN-dependent antiviral responses [40], [42]."

| PMC

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➶

reach

"In contrast, RV inhibition of IFNdirected STAT1 activation in RV-infected cells is well characterized [26, 52, 67] ."

| PMC

---

➶

reach

"Furthermore, RV infection was observed to block the migration of STAT1, STAT2 and NF-kappaB to the nucleus, thus preventing host cell immune responses [XREF_BIBR]."

29231855

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➶

reach

"In these situations, discovering novel therapeutic modalities that can dampen IFN signaling is potentially valuable.Other RV strategies have also been identified that are directed at disrupting STAT1 signaling during infection."

| PMC

Ac-Asp-Glu-Val-Asp-H affects CASP1

1 | 4

Ac-Asp-Glu-Val-Asp-H inhibits CASP1. 5 / 5

1 | 4

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➶

tas

No evidence text available

14741294

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➶

reach

"This enhancement was abolished when 0.5 mM of Ac-YVAD-CHO (inhibitor of casp-1) or Ac-DEVD-CHO (inhibitor of casp-3) was added to the reaction mixture [21]."

10828442

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➶

reach

"The aleurone layers treated with distilled water exerted caspase-1 and VPE activity, both of which were inhibited by the caspase-1 specific inhibitor Ac-YVAD-CMK but not by the caspase-3 specific inhibitor Ac-DEVD-CHO."

32232682

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➶

reach

"In contrast, Z-YVAD-FMK, Ac-DEVD-CHO, and Ac-LEVD-CHO, which inhibit caspase-1, caspase-3/7, and caspase-4, respectively, did not restrict the cytotoxicity or pyroptotic morphological changes in 0909I E. piscicida infected ZF4 cells."

30076291

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➶

reach

"This effect was inhibited by the tetrapeptide Ac-DEVD-CHO, a competitive inhibitor of the interleukin-1 beta converting enzyme (ICE)-related protease CPP32, but was not influenced by Ac-YVAD-CHO and Ac-YVAD-CMK, two specific inhibitors of ICE."

8896444

5E-7-oxozeaenol affects MAP3K7

5 |

5E-7-oxozeaenol inhibits MAP3K7. 5 / 5

5 |

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➶

tas

No evidence text available

25529738

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➶

tas

No evidence text available

21316225

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➶

tas

No evidence text available

27448772

---

➶

tas

No evidence text available

26481152

---

➶

tas

No evidence text available

28011204

3-(trimethylsilyl)propane-1-sulfonic acid affects NLRP3

| 5

3-(trimethylsilyl)propane-1-sulfonic acid inhibits NLRP3. 5 / 5

| 5

---

➶

reach

"Ginsenoside Rk3 alleviated DSS induced ulcerative colitis by protecting colon barrier and inhibiting NLRP3 inflammasome pathway."

32521491

---

➶

reach

"In this study, we for the first time verified that formononetin could alleviate the DSS induced acute colitis in mice by inhibiting NLRP3 pathway."

29507526

---

➶

reach

"In conclusion, JWSYD improved DSS induced UC in mice, probably by reducing inflammatory cytokines and inhibiting the NLRP3 inflammasome."

32565784

---

➶

reach

"Our study here characterized that inhibitors of MALT1, would be safe and potent for the treatment of DSS induced murine colitis by inhibiting NF-kappaB and NLRP3 inflammasome activation in macrophage."

27105502

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➶

reach

"Thus, our research shows that GDF11 alleviates DSS induced colitis by inhibiting NLRP3 inflammasome activation, providing some basis for its potential use in the treatment of UC."

30188752

2-aminoethoxydiphenylborane affects NLRP3

| 5

2-aminoethoxydiphenylborane inhibits NLRP3. 5 / 5

| 5

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➶

reach

"These findings demonstrate that 2-APB inhibits NLRP3 inflammasome signaling downstream of K + efflux signals and independently of its canonical actions as an inhibitor of IP 3 R/SOCE mediated increases in [Ca 2+]."

25762778

---

➶

reach

"While 2-APB blocks SOCE and inhibits NLRP3 inflammasome activation, these proteins have not been examined genetically in the context of NLRP3 activation."

25879282

---

➶

reach

"In addition, we found that the constitutive IL-1beta secretion from CAPS PBMCs was also substantially reduced by blockers of InsP 3 -mediated intracellular Ca 2+ signalling pathways, 2-APB and BAPTA-AM, (XREF_FIG and XREF_SUPPLEMENTARY), which can also inhibit NLRP3 inflammasome activation induced by ATP or extracellular Ca 2+ (XREF_FIG)."

23143333

---

➶

reach

"Suppression of nigericin stimulated NLRP3 inflammasome signaling by BAPTA and 2-APB can be dissociated from perturbation of Ca 2+ signaling."

25762778

---

➶

reach

"Previous studies have demonstrated that 2-APB strongly inhibits NLRP3 inflammasome activation in response to nigericin and other stimuli."

25762778

2-(carbamoylamino)-5-(4-fluorophenyl)-3-thiophenecarboxamide affects JAK1

| 2 3

2-(carbamoylamino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits JAK1. 5 / 5

| 2 3

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➶

sparser

"To directly examine whether TPCA-1 inhibits phosphorylation of STAT1 and STAT2 via inhibition of JAK1, we performed an in situ kinase activity assay using a purified recombinant human JAK1 in the presence of TPCA-1, ruxolitinib or BMS-345541 ( xref ). ruxolitinib and TPCA-1 were able to inhibit JAK1 kinase activity in a dose dependent manner with an IC 50 of 4.33 nM and 43.78 nM, respectively, while BMS-345541 did not affect the kinase enzymatic activity."

26331681

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➶

reach

"These data provide biochemical evidence that TPCA-1 directly inhibits JAK1 kinase, which can explain inhibition of STAT1 and STAT2 phosphorylation in vitro (XREF_FIG)."

26331681

---

➶

reach

"ruxolitinib and TPCA-1 were able to inhibit JAK1 kinase activity in a dose dependent manner with an IC 50 of 4.33 nM and 43.78 nM, respectively, while BMS-345541 did not affect the kinase enzymatic activity."

26331681

---

➶

sparser

"These data provide biochemical evidence that TPCA-1 directly inhibits JAK1 kinase, which can explain inhibition of STAT1 and STAT2 phosphorylation in vitro ( xref )."

26331681

---

➶

reach

"Moreover, an in situ kinase assay provided biochemical evidence that TPCA-1 directly inhibits JAK1 kinase activity."

26331681

2-(2-amino-3-methoxyphenyl)chromen-4-one affects FOS

| 2 1 2

2-(2-amino-3-methoxyphenyl)chromen-4-one inhibits FOS. 5 / 5

| 2 1 2

---

➶

reach

"In S9 cells, PD-98059 suppressed c-Fos upregulation by OD10 supernatant, Hla, or Hlb, indicating that c-Fos expression requires activation of Erk-type MAP kinases."

19098123

---

➶

reach

"The role of the ERK signaling cascade in gene regulation was confirmed after intrastriatal and unilateral injection of the specific ERK inhibitor PD 98059, which completely abolished c-fos, zif 268, and MKP-1 mRNA induction in the injected side."

9786988

---

➶

medscan

"The proliferative responses of HepG2 to trypsin and SLIGKV-NH2 were associated with the upregulation of c-fos and PCNA, which were significantly blocked by PD98059 pretreatment."

22940775

---

➶

medscan

"The proliferation-enhancing effects and the up-regulation of mRNA and protein of c-fos and PCNA induced by trypsin or SLIGKV-NH(2) were significantly blocked by pretreatment with PD98059 (P < 0.01)."

20193273

---

➶

sparser

"These results contrasted with hormone-dependent activation of the SRE in the c-fos promoter, which was inhibited by both PD98059 and LY294002."

15449318

2-(1,3-benzothiazol-2-yl)-2-[2-[2-(3-pyridinyl)ethylamino]-4-pyrimidinyl]acetonitrile affects MAPK8

5 |

2-(1,3-benzothiazol-2-yl)-2-[2-[2-(3-pyridinyl)ethylamino]-4-pyrimidinyl]acetonitrile inhibits MAPK8. 5 / 5

5 |

---

➶

tas

No evidence text available

18313304

---

➶

tas

No evidence text available

15999997

---

➶

tas

No evidence text available

20146479

---

➶

tas

No evidence text available

17850214

---

➶

tas

No evidence text available

18077363

1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea affects MAPK14

5 |

1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea inhibits MAPK14. 5 / 5

5 |

---

➶

tas

No evidence text available

12086485

---

➶

tas

No evidence text available

12941343

---

➶

tas

No evidence text available

14561086

---

➶

tas

No evidence text available

15115396

---

➶

tas

No evidence text available

16783341

(R)-lipoic acid affects RELA

| 5

(R)-lipoic acid inhibits RELA. 5 / 5

| 5

---

➶

reach

"The results showed that inhibitor of phosphatidylinositol 3-kinase prevented LA mediated suppression of LPS induction of RelA and expression of iNOS."

23892131

---

➶

reach

"LA suppressed IL-33-induced activation of NFkappaB p65, JNK, ERK, and TAK1, without altering p38 phosphorylation (XREF_FIG)."

27559047

---

➶

reach

"Heat killed LA failed to attenuate PAF induced increase in nuclear p65, whereas, similar to live LA, its CS (diluted 1:10 in DMEM and F12) was equally effective in attenuating the PAF effects on nuclear p65 (XREF_FIG)."

24130731

---

➶

reach

"As shown in XREF_FIG, the two species, L. acidophilus (LA) and L. rhamnosus (LR) significantly attenuated the PAF induced increase in nuclear p65, whereas the other two species were ineffective."

24130731

---

➶

reach

"Interestingly, our current studies also showed that heat killed LA failed to attenuate PAF induced increase in nuclear p65 and importantly, bacteria-free CS of LA was as effective as live LA in attenuating the PAF effects on nuclear p65, indicating that LA effects on PAF induced NF-kappaB activation are mediated by secreted soluble factor (s) in the CS."

24130731

3',5'-cyclic AMP affects NFKB1

| 5

3',5'-cyclic AMP inhibits NFKB1. 5 / 5

| 5

---

➶

reach

"CAMP and NF-KB Elevated levels of cAMP are known to inhibit acti- vation of NF-KB (Refs 77-79; Fig. 3)."

8579753

---

➶

reach

"Specifically, cAMP actives PKA, negatively regulates NF-KB pathway, thus suppressing the release of proinflammatory mediators (eg, TNF-alpha, interleukin-17, Interferon-gamma) XREF_BIBR."

25549252

---

➶

reach

"Interestingly, PGE2 or di-butyryl (Bt2) cAMP abolished the binding of NF-kappa B (p50 and p65) heterodimer to the kappa B sequence in cells stimulated with anti-CD3 mAb but not with PMA and A23187."

8018594

---

➶

reach

"In CD4 + T-cells, CGRP induces elevation of cellular cAMP levels and inhibits production of TNF-alpha, IFN-gamma, and NFkB."

29690884

---

➶

reach

"However, NF-KB activation in human promyelocytic HL 60 cells by TNF-a or -treatment was independent of intracellular cAMP levels (Hohmann et al., 1991) and inhibition or down regulation of classical protein kinase C isotypes failed to prevent TNF-a-mediated NF-KB activation (Meichle et al., 1990)."

7584622

Zinc atom affects IKBKB

| 4 1

Zinc atom inhibits IKBKB. 3 / 3

| 2 1

---

➶

sparser

"For example, the IκB kinase (IKK) members IKKα and IKKβ are inhibited by zinc, albeit at high concentrations of ∼0.5 μM (139)."

31305906

---

➶

reach

"Related to this, our group has discovered that transport of Zn through the Zn transporter ZIP8 into the cytosol functions to inhibit IKKbeta in monocytes and lung tissue, thereby controlling the extent of NF-kappaB activation and inflammation in response to sepsis XREF_BIBR, XREF_BIBR."

24732911

---

➶

sparser

"For example, the IκB kinase (IKK) members IKKα and IKKβ are inhibited by zinc, albeit at high concentrations of ∼0.5 µM (139)."

31305906

Zinc atom inhibits IKBKB. 2 / 2

| 2

---

➶

sparser

"To understand whether zinc selectively inhibits IKKα and/or IKKβ, we exposed IKKβ (−/−) mouse embryonic fibroblast (MEFs) to IL-1β and evaluated NF-κB-mediated function."

23403290

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➶

sparser

"Very recently, direct inhibition of IKKβ [IκB (inhibitor of NF-κB) kinase β] by zinc was reported [ xref ], while others have also shown that zinc indirectly inhibits IKKβ via cGMP-dependent activation of PKA (protein kinase A) [ xref ]."

23738776

Quercetin affects IKBKB

| 5

Quercetin inhibits IKBKB. 4 / 4

| 4

---

➶

sparser

"Here we demonstrate that quercetin and staurosporine potently inhibit both IKKalpha and IKKbeta."

10551820

---

➶

sparser

"This Letter describes the results of two combined approaches: homology modeling and molecular docking studies, in order to propose the molecular basis of IKKbeta inhibition by staurosporine and quercetin as ATP-competitive inhibitors."

19896375

---

➶

sparser

"Quercetin inhibits the purified recombinant IκB kinases, IKK1 and IKK2, by serving as a mixed-type inhibitor versus ATP [16] ."

11543732

---

➶

sparser

"Structural insights into IKKbeta inhibition by natural products staurosporine and quercetin."

19896375

Quercetin inhibits IKBKB. 1 / 1

| 1

---

➶

sparser

"We found that quercetin promotes cisplatin-induced apoptosis in human OSCC (cell lines Tca-8113 and SCC-15) by down-regulating NF-κB. Pretreatment of cancer cells with quercetin inhibited the phosphorylation Akt and IKKβ, and led to the suppression of NF-κB and anti-apoptotic protein xIAP."

31528215

Glucocorticoid affects JUN

| 3 2

Glucocorticoid inhibits JUN. 4 / 4

| 2 2

---

➶

reach

"It is thought that protein protein interactions similar to those described for GR-NF-kappaB are involved with GC inhibition of activator protein-1 (AP-1) and nuclear factor of activated T lymphocytes (NF-AT)."

12909458

---

➶

reach

"It was demonstrated that GC inhibit the assembly of c-Fos and c-Jun to form functional activator protein-1 [28]."

11306142

---

➶

sparser

"It is thought that protein–protein interactions similar to those described for GR–NF-κB are involved with GC inhibition of activator protein-1 (AP-1) and nuclear factor of activated T lymphocytes (NF-AT)."

12909458

---

➶

sparser

"It is thought that protein–protein interactions similar to those described for GR–NF-κB are involved with GC inhibition of activator protein-1 (AP-1) and nuclear factor of activated T lymphocytes (NF-AT)."

12909458

Glucocorticoid inhibits JUN. 1 / 1

| 1

---

➶

sparser

"Dexamethasone, a synthetic glucocorticoid that inhibits activator protein-1 (AP-1), blocked palytoxin-stimulated MMP-13 gene expression."

14575638

Gallic acid affects STAT1

| 5

Gallic acid inhibits STAT1. 4 / 4

| 4

---

➶

reach

"Glatiramer acetate (GA), a FDA approved treatment for MS, was shown to promote activation of anti-inflammatory monocytes by reducing STAT1 signaling."

27713030

---

➶

reach

"These results suggest that GA could inhibit the activations of STAT1 and -3 in PBMCs, in addition to brain resident immune cells."

28094337

---

➶

reach

"GA attenuates the STAT1 and -3 signaling in peripheral blood mononuclear cells, but not neuronal cells."

28094337

---

➶

reach

"These results indicate that the ability of GA to inhibit the activations of STAT1 and -3 is not mediated through IFNgamma -/- or IFNgammaR -/- system."

28094337

Gallic acid bound to Ig inhibits STAT1. 1 / 1

| 1

---

➶

reach

"In this study, we demonstrate that GA interacts with murine paired Ig like receptor B (PIR-B) on myeloid derived suppressor cells and suppresses the STAT1 and NF-kappaB pathways while promoting IL-10 and TGF-beta cytokine release."

30068593

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one affects TYK2

4 1 |

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one inhibits TYK2. 4 / 4

4 |

---

➶

tas

No evidence text available

26351728

---

➶

tas

No evidence text available

11934592

---

➶

tas

No evidence text available

18077363

---

➶

tas

No evidence text available

18844338

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one inhibits TYK2. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

Lipopolysaccharide affects MYD88

| 5

Lipopolysaccharide bound to TLR4 inhibits MYD88. 2 / 2

| 2

---

➶

reach

"Convincing researches have indicated that LPS, a major component of Gram negative bacterial cytoderm, binds to TLR4 and triggers MyD88 mediated signaling cascades activation of NF-kappaB, and eventually leads to inflammatory response."

30042683

---

➶

reach

"Moreover, the competitive binding of gCTRP9 and LPS to the myeloid differentiation protein 2 (MD2) and TLR4 complex was associated with direct binding to MD2, thereby inhibiting the downstream signaling molecule MyD88."

30953351

Lipopolysaccharide bound to LY96 inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Moreover, the competitive binding of gCTRP9 and LPS to the myeloid differentiation protein 2 (MD2) and TLR4 complex was associated with direct binding to MD2, thereby inhibiting the downstream signaling molecule MyD88."

30953351

Lipopolysaccharide bound to TLR4 receptor inhibits MYD88. 1 / 1

| 1

---

➶

reach

"LPS is a component of the outer membrane of Gram negative bacteria and specifically binds to the TLR4 receptor, triggering both the downstream MyD88 and TRIF dependent pathways."

24244133

Modified lipopolysaccharide inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Triptolide treatment suppressed the mRNA and protein levels of LPS induced TLR4 and TRIF expression but not MyD88 (data not shown)."

20385024

Withaferin A affects IKBKB

| 3 1

Withaferin A inhibits IKBKB. 4 / 4

| 3 1

---

➶

medscan

"In the canonical pathway induced by TNF, Withaferin A did not disrupt RIP1 polyubiquitination or NEMO-IKKβ interaction and was a poor direct IKKβ inhibitor, but prevented the formation of TNF-induced NEMO foci which colocalized with TNF ligand."

25304104

---

➶

reach

"However, how this impacts NF-kappaB signaling is currently unclear and it was also shown that WA can inactivate IKKbeta directly by targeting Cys179 in the kinase domain XREF_BIBR."

26740240

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➶

medscan

"Together with the co-immunoprecipitation experiments above, our results are inconsistent with the hypothesis that Withaferin A disrupts the protein-protein interaction between NEMO and IκB kinaseβ."

25304104

---

➶

medscan

"However, our mechanistic data were inconsistent with the concept that Withaferin A disrupts the NEMO-IκB kinaseβ interaction."

25304104

Vorinostat affects RELA

2 | 2

Vorinostat inhibits RELA. 4 / 4

2 | 2

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➶

ctd

No evidence text available

12893773

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➶

reach

"Furthermore, SAHA inhibited the NF-kappaB-dependent reporter gene expression activated by TNF, TNFR1, TRADD, TRAF2, NF-kappaB-inducing kinase, IkappaBalpha kinase, and the p65 subunit of NF-kappaB."

16377638

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"At the molecular level, it was found that upregulation of IkappaBalpha and the p50 and p65 subunits of nuclear factor-kappaB induced by ZD55-TRAIL, can be abrogated by SAHA treatment."

25684632

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➶

ctd

No evidence text available

19643600

Vigabatrin affects TRIM25

| 4

Vigabatrin inhibits TRIM25. 4 / 4

| 4

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➶

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"Again, vigabatrin reduced the frequency of EFP in a concentration dependent manner."

10924922

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➶

reach

"The EFP were significantly decreased in frequency by vigabatrin in bath concentrations of 100 and 200 mumol/l."

10924922

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➶

reach

"Vigabatrin reduced the frequency of EFP in a concentration dependent manner."

10924922

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➶

reach

"In control experiments with neocortical slices from rats, vigabatrin reduced EFP in a comparable range."

10924922

Vancomycin(1+) affects MAVS

| 4

Vancomycin(1+) inhibits MAVS. 4 / 4

| 4

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"Mechanisms of vancomycin resistance of VISA and hVISA are still unclear."

29403293

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➶

reach

"Several studies examined the mutated forms of WalKR in vancomycin resistance of VISA."

27790199

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➶

reach

"Factors such as the increased synthesis of non amidated muropeptides and the resultant reduced peptidoglycan cross linking contribute to the vancomycin resistance of VISA through increased affinity trapping of vancomycin XREF_BIBR."

23840544

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➶

reach

"However, GraS-T136I alone is not sufficient to convert VSSA to the full vancomycin resistance of VISA."

27790199

Trichostatin A affects IFNB1

| 4

Trichostatin A inhibits IFNB1. 4 / 4

| 4

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"Examination of additional microglial chemokine and antiviral genes (XREF_FIG and XREF_FIG, and XREF_FIG and XREF_FIG, respectively) demonstrated that IP-10, IFNbeta, IDO and viperin mRNA were all strongly inhibited by TSA and VA, whereas SB216763 had much less and insignificant effects."

20157787

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"While both Bufexamac and TSA treatment blocked IFN-beta promoter induction by SenV in a dose dependent manner, treatment of cells with VPA did not decrease IFN-beta promoter induction as compared to nontreated cells (XREF_FIG A)."

27372014

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➶

reach

"TSA treatment has been shown previously to block IFN-beta production."

27372014

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➶

reach

"TSA also blocked IFN-beta promoter induction by the constitutively active N-RIG construct but importantly, Bufexamac treatment did not block IFN-beta promoter induction by N-RIG."

27372014

Trans-piceid affects NLRP3

| 4

Trans-piceid inhibits NLRP3. 4 / 4

| 4

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"Polydatin Inhibits NLRP3 Inflammasome in Dry Eye Disease by Attenuating Oxidative Stress and Inhibiting the NF-kappaB Pathway."

31731792

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➶

reach

"In earlier reports, polydatin suppresses NLRP3 inflammasome activation and ameliorates potassium oxonate induced kidney inflammation in rats XREF_BIBR, and enhances PPAR-alpha and inhibits SCD-1 in animal models induced by streptozocin or a high-fat diet XREF_BIBR, XREF_BIBR."

30014902

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➶

reach

"In addition, the hyperosmolar stress induced NLRP3 inflammasome pathway and ROS production were inhibited by polydatin."

31731792

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➶

reach

"This could be of potential therapeutic relevance.In earlier reports, polydatin suppresses NLRP3 inflammasome activation and ameliorates potassium oxonate induced kidney inflammation in rats [20], and enhances PPAR-alpha and inhibits SCD-1 in animal models induced by streptozocin or a high-fat diet [21,22]."

30014902

Topiramate affects STAT1

| 4

Topiramate inhibits STAT1. 4 / 4

| 4

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"TPM reduces NADPH oxidase components and stat1 activation."

30337926

---

➶

reach

"Third, TPM treated neutrophils have reduced activation of STAT1, a key transcription factor involved in the expression of iNOS and key NADPH oxidase components such as gp91."

30337926

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➶

reach

"Mechanistically, we documented that TPM primed neutrophils have reduced STAT1 activation following subsequent LPS challenge."

30337926

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➶

reach

"Taken together, our study reveals novel mechanisms for TPM mediated neutrophil reprogramming with reduced bacterial killing activity, in that TPM reduces STAT1 mediated expression of key anti-bacterial molecules such as gp90 and iNOS."

30337926

Tofacitinib affects ITCH

| 4

Tofacitinib inhibits ITCH. 4 / 4

| 4

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"Tofacitinib may inhibit psoriatic itch through inhibition of cytokine expression as well as modulation of epidermal innervation."

30460374

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➶

reach

"High dose of hypochlorous acid and tofacitinib reduce lesions and itch in the murine NC/Nga model of AD."

29970189

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➶

reach

"The dose selection for tofacitinib was according to a former study in which 0.5% tofacitinib inhibited itch behaviour and inflammation in a mouse model of allergic contact dermatitis, higher doses (when given in acetone) led to irritation of mouse skin, thus it was decided to select a concentration of 0.5% [XREF_BIBR]."

29970189

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➶

reach

"Tofacitinib significantly reduced itch vs. placebo (P < 0.05 both doses) and etanercept (P < 0.0001 both doses) within 1 day of starting treatment."

27271195

Tetrodotoxin affects FOS

| 4

Tetrodotoxin inhibits FOS. 4 / 4

| 4

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"In sciatic nerve ligated rats, TTX administration prevented the increased c-Fos immunoreactivity occurring in the dorsal horn of the lumbar cord and some supraspinal areas in response to light mechanical stimulation of the nerve injured hindpaw."

19747496

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➶

reach

"C-Fos induction was blocked by TTX but not by AMPA or NMDA receptor antagonists, suggesting that c-Fos upregulation requires action potential firing, but not excitatory synaptic input."

19997631

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➶

reach

"In contrast, tetrodotoxin abolished induction of c-fos and zif268 messenger RNAs by the D2 antagonist eticlopride (0.5 mg/kg, i.p.) in both intact rats and dopamine depleted rats receiving continuous D2 agonist treatment (quinpirole, 0.5 mg/kg/day)."

10077330

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➶

reach

"Application of the Na + channel blocker TTX during stimulation blocked c-Fos induction, indicating that spiking activity was necessary to trigger the signaling cascade leading to c-Fos expression (XREF_FIG)."

19997631

Tepoxalin affects NFKB1

| 4

Tepoxalin inhibits NFKB1. 4 / 4

| 4

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"Tepoxalin also inhibits the activation of NFKB, a transcription factor which acts pn several cytokine genes."

8707445

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➶

reach

"Whether Tepoxalin inhibits NF-KB induc- tion by other ER stress- eliciting agents remains to be investigated."

9048485

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➶

reach

"Certain analogs of tepoxalin that had previously been shown to inhibit NF-KB activation were also the most potent inhibitors of PGHS1 peroxidase activity."

9383435

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reach

"Its immunosuppressive property is distinct from cyclosporin because only tepoxalin, but not cyclosporin, suppresses NF-KB activation."

9024987

Temozolomide affects NFKB1

| 1 3

Temozolomide inhibits NFKB1. 4 / 4

| 1 3

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➶

eidos

"As with U87 cells , TMZ blocked p50 and induced p53 recruitment in cells expressing p50wt ( Figure 4C , left panel ) ."

30940658

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➶

reach

"The mechanism by which TMZ reduces NFkB activity in glioma cells is still poorly understood."

26520369

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➶

reach

"DHT and TMZ synergistically reduce cancer cell viability, NFkB activity, and markedly halt cell cycle progression."

30399573

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➶

reach

"However, the observation that similar levels of gammaH2AX foci are induced in wt and p50 depleted cells by TMZ (XREF_FIG) suggests that the resistance to cytotoxicity with loss of p50 is not due to decreased DSB formation or increased DSB repair."

22152481

Tamoxifen affects MYD88

| 4

Tamoxifen inhibits MYD88. 4 / 4

| 4

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"Specific tamoxifen induced MyD88 deletion in intestinal epithelial cells protects against diet induced obesity, is associated with increased energy expenditure, improves glucose homeostasis, and reduces hepatic steatosis and whole-body fat mass by 30%."

27105827

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➶

reach

"The intestinal MyD88 deletion is induced by a tamoxifen injection in adult animals before starting the dietary intervention (XREF_FIG)."

25476696

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➶

reach

"To evaluate the role in vivo of MyD88 expression in cardiomyocytes, we generated Mer + MyD88flox +/+ mice in which tamoxifen treatment is expected to eliminate the MyD88 gene exclusively in cardiomyocytes."

30067739

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➶

reach

"Tamoxifen treatment induces MyD88 gene deletion in cardiomyocytes of double transgenic Mer + MyD88flox +/+ mice."

30067739

Tacrolimus (anhydrous) affects NFKBIA

| 4

Tacrolimus (anhydrous) inhibits NFKBIA. 4 / 4

| 4

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"In the present study, we analyzed mechanisms by which FK506 induces IkappaBalpha degradation."

10574930

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➶

reach

"However, unlike IL-1-induced degradation, IKK-1 and IKK-2 were not activated significantly nor was FK506 induced IkappaBalpha degradation dependent on the N-terminal ubiquitination sites (Lys 21 and Lys 22)."

10574930

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➶

reach

"We found that FK506 induces the degradation of both IkappaBalpha and IkappaBbeta and that the time courses of the FK506 induced degradation are quite different from degradation induced by interleukin 1 (IL-1)."

10574930

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➶

reach

"Despite this difference, FK506 induced IkappaBalpha degradation was dependent on the N-terminal Ser 32 and Ser 36 phosphorylation sites and was mediated by proteasomes, as is the case for IL-1-induced IkappaBalpha degradation."

10574930

Sunitinib affects TYK2

4 |

Sunitinib inhibits TYK2. 4 / 4

4 |

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➶

tas

No evidence text available

---

➶

tas

No evidence text available

22037378

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➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

19654408

Sunitinib affects TBK1

3 | 1

Sunitinib inhibits TBK1. 4 / 4

3 | 1

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➶

tas

No evidence text available

19654408

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➶

reach

"However, this is apparently mostly attributable to relatively high TBK1 expression levels, as in vitro kinase assays, while confirming this interaction, do not suggest that sunitinib would cause sufficiently potent TBK1 inhibition at physiologically relevant concentrations."

25189542

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➶

tas

No evidence text available

---

➶

tas

No evidence text available

22037378

Sunitinib affects IKBKE

4 |

Sunitinib inhibits IKBKE. 4 / 4

4 |

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➶

tas

No evidence text available

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

Sulforaphane affects CASP1

| 4

Sulforaphane inhibits CASP1. 4 / 4

| 4

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reach

"When SFN was added directly to the cell lysates, it did not inhibit IL-1beta processing, demonstrating that SFN does not directly inhibit the protease activity of caspase-1."

27672241

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➶

reach

"Earlier reports have suggested that SFN inhibited caspase-1 cleavage and IL-1beta maturation for the NLRP1b, NLRP3, NAIP5 and NLRC4, and AIM2 inflammasomes in immune cells [XREF_BIBR]."

27847555

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➶

reach

"SFN inhibited palmitate induced production of caspase-1 (p10) and mature IL-1beta in hepatocyte cell supernatant (XREF_FIG)."

27075683

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➶

reach

"Oral administration of SFN inhibited HFD induced upregulation of ASC and caspase-1 in the liver (XREF_FIG)."

27075683

Staurosporine affects TYK2

4 |

Staurosporine inhibits TYK2. 4 / 4

4 |

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tas

No evidence text available

22037378

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➶

tas

No evidence text available

18183025

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➶

tas

No evidence text available

28259529

---

➶

tas

No evidence text available

27288183

Sodium(1+) affects ITCH

| 4

Sodium(1+) inhibits ITCH. 4 / 4

| 4

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reach

"In addition, creams containing local anesthetics [XREF_BIBR], capsaicin, doxepin [XREF_BIBR], strontium nitrate [XREF_BIBR], or nedocromil sodium [XREF_BIBR] can be helpful to relieve itch."

26064156

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➶

reach

"Two studies show that VGLUT2 dependent glutamate release from a group of primary sensory afferents marked by the expression of the Nav1.8 sodium channel is required to sense pain and suppress itch in mice [XREF_BIBR, XREF_BIBR]."

22466120

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➶

reach

"In study 1, nedocromil sodium, frusemide and bumetanide reduced itch scores by 36%, 48% and 34%, respectively, and flare areas by 17%, 26% and 15% respectively (all P < 0.05)."

15005740

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➶

reach

"The results showed that nedocromil sodium reduced itch scores, totalled over 5 min, by approximately 74.0% (P < 0.005) and flare areas by approximately 65% (P < 0.03)."

11159712

Sirolimus affects IFNB1

| 4

Sirolimus inhibits IFNB1. 4 / 4

| 4

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reach

"Rapamycin additionally diminished the IFNbeta response to CpG-A and CpG-B in DNA-PKcs- or DNA-PKcs and Ku70-deficient BMDCs (XREF_FIG)."

25812014

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➶

reach

"As shown in XREF_FIG, both anti--IFNAR2 antibody and rapamycin inhibited IFNbeta induction of OAS2 RNA; inhibition by anti--IFNAR2 was rapid (within 24 h), while inhibition by rapamycin was only evident at 72 hr."

28107341

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➶

reach

"Rapamycin also significantly inhibited pDC secretion of IFN-beta, TNF and IL-6 (XREF_FIG and XREF_SUPPLEMENTARY online)."

18758466

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➶

reach

"Including rapamycin increased the survival of established tumor bearing mice, as rapamycin treatment reduced the local IFNb production."

23726825

Silicon dioxide affects MYD88

| 4

Silicon dioxide inhibits MYD88. 4 / 4

| 4

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"In conclusion, as shown in XREF_FIG, miR-489 may function as an anti-fibrotic miRNA in silica induced pulmonary fibrosis by targeting MyD88 and Smad3, and the lncRNA CHRF inhibits miR-489 expression, thus resulting in the activation of inflammation and the fibrotic signaling pathways."

27506999

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➶

reach

"miR-489 inhibits silica induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF."

27506999

---

➶

reach

"This study is the first to report that miR-489 attenuates silica induced pulmonary fibrosis by directly repressing MyD88 and Smad3, and that it is regulated by CHRF."

27506999

---

➶

reach

"How to cite this article : Wu, Q. et al. miR-489 inhibits silica induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF."

27506999

Silibinin affects RELA

| 1 3

Silibinin inhibits RELA. 4 / 4

| 1 3

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➶

medscan

"The results were as follows: (i) silibinin inhibited the expression of the MUC5AC mucin gene induced by EGF, PMA or TNF-α from NCI-H292 cells; (ii) silibinin also inhibited the production of MUC5AC mucin protein induced by the same inducers from NCI-H292 cells; (iii) silibinin inhibited the activation of NF-κB p65 by TNF-α in NCI-H292 cells; (iv) silibinin significantly decreased adenosine triphosphate-induced mucin secretion from cultured rat tracheal surface epithelial cells."

22275269

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➶

reach

"In vivo studies conducted in mouse models indicate that topical application of silibinin inhibits UVB induced expression levels of ERK1/2 and p38 proteins of MAPK family, and subsequently inhibited the activation of NF-kappaB and p65 through inhibition of degradation of IkappaBalpha and activation of IKKalpha."

20372777

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➶

reach

"Western immunoblot analysis further showed that silymarin reduced p65 in the nucleus (XREF_FIG)."

25954125

---

➶

reach

"Results indicated that compared to their respective controls, the immunoreactivity score of total p65 decreased by 28% in silibinin fed LoVo xenografts (P < 0.05), whereas the decrease was 75% (P < 0.001) in case of SW480 (XREF_FIG)."

22086675

Sevoflurane affects JUN

| 4

Sevoflurane inhibits JUN. 4 / 4

| 4

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reach

"Sevoflurane inhibited activation of the transcription factor AP-1."

15329596

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➶

reach

"However, in vitro studies using human CD3 T cells showed that sevoflurane suppressed activation of transcription factor AP-1, which plays a role in T cell inflammatory activation [XREF_BIBR] as well as inducing apoptosis [XREF_BIBR]."

23253693

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➶

reach

"Sevoflurane inhibits phorbol-myristate-acetate-induced activator protein-1 activation in human T lymphocytes in vitro : potential role of the p38-stress kinase pathway."

15329596

---

➶

reach

"144 In isolated T cells, sevoflurane inhibited activation of the transcription factor Activator Protein-1 (AP-1), which was associated with the inhibition of p38 activity and resulted in a decreased IL-3 expression."

27286478

Rosiglitazone affects RELA

| 1 3

Rosiglitazone inhibits RELA. 4 / 4

| 1 3

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➶

medscan

"Rosiglitazone induced significant downregulation of NF-kappaB P65 expression in both groups."

20021931

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➶

reach

"Importantly, this inducible association of p65 and RelA with both promoters was blocked when cells were treated with rosiglitazone."

19556516

---

➶

reach

"Rosiglitazone inhibited the I/R induced activation of NF-kappaB p65 after 8 and 24 h reperfusion."

26893620

---

➶

reach

"Importantly, this inducible association of p65 and RelA with both promoters was blocked when cells were treated with rosiglitazone."

19556516

Retinoic acid affects CASP1

| 4

Retinoic acid inhibits CASP1. 4 / 4

| 4

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➶

reach

"In inner ear tissue, RA also inhibited the caspase-1 activation (XREF_FIG)."

21526214

---

➶

reach

"To determine if DSE or RA inhibits caspase-1 activation induced by cisplatin, cells were exposed to cisplatin in the presence or absence of various concentrations DSE or RA."

21526214

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➶

reach

"Pretreatment of RA inhibited caspase-1 downstream signal pathway, such as the activation of caspase-3 and 9, release of cytochrome c, translocation of apoptosis inducing factor, up-regulation of Bax, down-regulation of Bcl-2, generation of reactive oxygen species, and activation of nuclear factor-kappaB."

21526214

---

➶

reach

"RA inhibits caspase-1 activation."

21526214

Resveratrol affects TBK1

| 4

Resveratrol inhibits TBK1. 4 / 4

| 4

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➶

reach

"For instance, resveratrol inhibits the kinase activity of TANK binding kinase 1 associating with TRIF, which is the TLR4 downstream component, resulting in decreasing the NF-kappaB and IRF-3 activation [XREF_BIBR, XREF_BIBR]."

30248132

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➶

reach

"SHP-2, resveratrol isoliquiritigenin and glucocorticoid inhibit TBK1 kinase activity."

23395611

---

➶

reach

"In further delineating the target of resveratrol, it was found that resveratrol inhibited the kinase activity of TBK1 and the NF-kappaB activation induced by RIP1 [XREF_BIBR] (XREF_FIG)."

21631512

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➶

reach

"Furthermore, resveratrol inhibited the kinase activity of TANK binding kinase 1 and the NF-kappaB activation induced by RIP1 in RAW264.7 cells."

16116226

Resveratrol affects CASP1

2 | 2

Resveratrol inhibits CASP1. 4 / 4

2 | 2

---

➶

ctd

No evidence text available

9680369

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➶

reach

"In a recent study [XREF_BIBR], it was found that resveratrol treatment successfully suppressed the maturation of both IL-1beta and caspase-1 in response to Pam3CSK4; a TLR1/2 agonist, plus various inducers (like nigericin, ATP, MSU, and silica) of the NLRP3-inflammasome."

27672241

---

➶

reach

"Resveratrol pretreatment also inhibited the activation of NLRP3 and caspase-1, and reduced the production of inflammatory cytokines and ROS."

29257276

---

➶

ctd

No evidence text available

20370652

Reactive oxygen species affects NFKBIA

| 4

Reactive oxygen species inhibits NFKBIA. 4 / 4

| 4

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➶

reach

"NF-kappaB translocation and transcriptional activity are dependent the degradation of IkappaB, which prevents NF-kappaB nuclear entry by covering the nuclear localization sequence XREF_BIBR, Therefore, we assessed the status of IkappaBalpha and found that IkappaBalpha degradation was dramatically induced by ROS accumulation following PQ treatment."

24714343

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➶

reach

"We observed that TC-HW-mediated NF-kappaB activation is followed by p65 nuclear accumulation through ROS dependent degradation of IkappaB-alpha."

29554905

---

➶

reach

"These data collectively indicated that this ROS mediated IkappaBalpha independent regulation on NF-kappaB activation may not be restricted by the specificity of stimulators or ROS scavengers."

24725826

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➶

reach

"The combination of ROS quenching by the free radical scavenger Tempol and of Bcl10 silencing by siRNA completely inhibited the CGN induced increases in nuclear NFkappaB (p65), phospho-IkappaBalpha, and secretion of IL-8."

18452717

Reactive oxygen species affects NFKB1

| 4

Reactive oxygen species inhibits NFKB1. 4 / 4

| 4

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➶

reach

"Importantly, PBN reduced ROS-inhibited HCQ and HCQ + MAVS-stimulated luciferase reporter activity of IFN-b, ISRE, and NFkB (Fig. 6G )."

25321315

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➶

reach

"Consistent with the premise that oxidative stress increases in the aging brain [XREF_BIBR], that ROS impairs NF-kappaB p50 function in microglia [XREF_BIBR], and that aging in peripheral tissues is associated with a loss of NF-kappaB p50 function [XREF_BIBR, XREF_BIBR], we found that 9-month-old mice exhibited less NF-kappaB p50 DNA binding in the brain when compared to younger 3-week-old mice."

30871598

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➶

reach

"The ROS scavengers N-acetyl cysteine (NAC) and superoxide dismutase (SOD) mimetic MnTBAP inhibited LPS induced accumulation of nuclear RelB and p50, but had no effects on nuclear RelA, c-Rel and p52 (XREF_FIG and XREF_SUPPLEMENTARY)."

25367573

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➶

reach

"We can hypothesize that ROS levels need to be sufficiently decreased to induce NFKB activation."

29285268

Quercetin affects NFKB1

1 | 3

Quercetin inhibits NFKB1. 4 / 4

1 | 3

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➶

reach

"Streptavidin-agarose pulldown and ChIP assay also showed that quercetin dramatically suppressed binding of p50 to the biotinylated COX-2 promoter probe (XREF_FIG) and the chromatin COX-2 promoter region (XREF_FIG) in p300 tranfected MDA-MB-231 cells."

21857970

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➶

reach

"Signaling study showed quercetin treatment inhibited MAPK but not NFkB activation."

29733461

---

➶

ctd

No evidence text available

18852136

---

➶

reach

"For example De Stefano et al., has shown that quercetin can inhibit NFkB activation in the RAW 264.7 macrophage cell line."

21391122

Pyruvic acid affects NFKB1

| 4

Pyruvic acid inhibits NFKB1. 4 / 4

| 4

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➶

reach

"At the in vitro level, ethyl pyruvate was found to inhibit nuclear factor kappa B (NFkB) activation in both cultured microglia and RAW 264.7 cells through a modification of its p65 subunit."

19635562

---

➶

reach

"A higher concentration of ethyl pyruvate was necessary to inhibit the binding of p50 than that of RelA (1-220), which was consistent with the results of BN PAGE."

20969857

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➶

reach

"Next, we examined whether ethyl pyruvate inhibited the binding of RelA (1-220) or p50 to the [32 P]-labeled NF-kappaB probe."

20969857

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➶

reach

"Pyruvate treatment significantly decreased overall NFkB staining, as well as numbers of cells with nuclear staining."

19635562

Propofol affects NFKBIA

| 4

Propofol inhibits NFKBIA. 4 / 4

| 4

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➶

reach

"As seen in XREF_FIG, relative to DMSO control propofol mediated IkappaBalpha degradation did not increase nuclear translocation of p65 at up to 4 h of propofol exposure."

25105067

---

➶

reach

"Propofol increases IkappaBalpha degradation."

25105067

---

➶

reach

"Propofol mediated IkappaBalpha degradation at 2 h was comparable to the positive control for IkappaBalpha degradation, TNFalpha."

25105067

---

➶

reach

"In this study, we demonstrated that propofol induced IkappaBalpha degradation, NFkappaB p65 subunit perinuclear translocation, and STAT3 nuclear translocation."

25105067

Progesterone affects RELA

1 | 3

Progesterone inhibits RELA. 4 / 4

1 | 3

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➶

reach

"The results showed that progesterone administration could significantly down-regulate the NF-kappaB p65 immunoreactivity in rat intestine following TBI."

18274644

---

➶

reach

"Progesterone has been reported to suppress NF-kappaB activity by increase IkappaBalpha transcription or inhibit p65 expression XREF_BIBR."

25080336

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➶

reach

"They found NF-kappaB p65 was increased in all injured animals and decreased by progesterone treatment in comparison to vehicle treated animals."

18274644

---

➶

ctd

No evidence text available

22615136

Potassium chloride affects NLRP3

| 4

Potassium chloride inhibits NLRP3. 4 / 4

| 4

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➶

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"High KCl is known to inhibit NLRP3 inflammasome activation and cell death by blocking K + efflux, a common trigger of NLRP3 inflammasome activation, as confirmed by the considerable reduction in released IL-1beta in the culture supernatant18, 19."

28035720

---

➶

reach

"Notably, the association of NLRP3 with Nek7 as well as caspase-1 activation triggered by ATP were blocked in the presence of 50 mM KCl that inhibits potassium efflux and NLRP3 activation (XREF_FIG)."

26814970

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➶

reach

"However, it was difficult to judge whether the effect of KCl was due to specific inhibition of the NLRP3 inflammasome, as the same concentration of KCl also decreased the cytokine responses of NLRP3 -/- macrophages to S. pneumoniae (data not shown)."

21957143

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reach

"Extracellular KCl, which prevents K + efflux and NLRP3 dependent caspase-1 activation, abrogated UBE2L3 depletion (XREF_FIG D)."

28147281

Poly I:C affects IRF3

| 4

Poly I:C inhibits IRF3. 4 / 4

| 4

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➶

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"Consistently, poly I : C induced IRF-3 dimerization was strongly impaired in NOX2 RNAi vs CTRL RNAi transfected cells (XREF_FIG)."

20532218

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➶

reach

"However, LY294002 has recently been shown to inhibit poly I : C induced IRF3 activation by an unknown, PI3K- independent mechanism [XREF_BIBR]."

23892079

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➶

reach

"Similarly, C272R mutant did not suppressed poly I : C induced IRF-3 nuclear translocation and interact with MDA5."

21071089

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➶

reach

"Mian et al. also observed that smoke conditioned media significantly suppressed the activation of NFkappaB and IRF-3 in nonsmokers ' PBMCs treated with poly I : C [XREF_BIBR], while cigarette smoke extract was shown to dramatically elevate the DNA binding activity of AP-1 rather than NFkappaB in endothelial cells of human umbilical core vein [XREF_BIBR]."

27902485

Phorbol 13-acetate 12-myristate affects FOS

| 4

Phorbol 13-acetate 12-myristate inhibits FOS. 4 / 4

| 4

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➶

reach

"Down-regulation of PKC by overnight pre-treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) blocked only the phorbol ester stimulated c-fos accumulation while no effect was observed in the carbachol induced response."

9037533

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➶

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"In addition, 5 '-NIO exerted strong inhibitory effects on the EGF- or TPA induced c-fos or c-jun transcriptional activity, and thereby inhibited the associated activator protein-1 (AP-1) transactivation activity induced by EGF or TPA."

21400615

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reach

"In addition, the cotreatment with RA reduced (5 micromol/L, P < 0.05; 10 and 20 micromol/L, P < 0.01) TPA induced transcription from a control activator protein-1 (AP-1) promoter-luciferase construct and repressed binding of the AP-1 factors c-Jun (10 micromol/L; P < 0.01) and c-Fos (10 micromol/L; P < 0.05) to COX-2 promoter oligonucleotides harboring a cAMP response element (CRE)."

18936204

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➶

reach

"Pretreatment with DHA resulted in significant inhibition of TPA induced activation of c-fos and c-jun (XREF_FIG)."

27654969

Phenethyl caffeate affects FOS

| 4

Phenethyl caffeate inhibits FOS. 4 / 4

| 4

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➶

reach

"CAPE was shown to suppress the receptor activator of the nuclear factors NF-kappaB, c-Fos, and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1), resulting in the attenuation of RANKL induced osteoclast differentiation [22,23]."

29957360

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➶

reach

"In addition, CAPE blocked the induction of NFATc1 and c-Fos following RANKL stimulation."

19285574

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➶

reach

"CAPE at 0.1-5 muM concentrations attenuated both c-Fos and c-Jun translations significantly (P <.001) enhanced with RANKL."

29957360

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➶

reach

"Caffeic acid phenethyl ester inhibits osteoclastogenesis by suppressing NF kappaB and downregulating NFATc1 and c-Fos."

19285574

Phenazine-1-carboxylate affects RELA

| 2 2

Phenazine-1-carboxylate inhibits RELA. 4 / 4

| 2 2

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➶

sparser

"Furthermore, PCA inhibited the nuclear content of p65, a subunit of nuclear factor-κB (NF-κB), along with reduced NF-κB binding activity."

21090717

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➶

reach

"Furthermore, PCA inhibited the nuclear content of p65, a subunit of nuclear factor-kappaB (NF-kappaB), along with reduced NF-kappaB binding activity."

21090717

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➶

sparser

"Furthermore, PCA inhibited the nuclear content of p65, a subunit of nuclear factor-κB (NF-κB), along with reduced NF-κB binding activity."

21090717

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➶

reach

"PCA, Bay 11-7085, Akt inhibitor, rapamycin and N -acetylcysteine inhibited lipopolysaccharide caused increase in the NF-kappaB p65 to DNA binding activity."

29291542

Parthenolide affects NFKBIA

| 4

Parthenolide inhibits NFKBIA. 4 / 4

| 4

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"Although the oleate activated AKT, IkappaBalpha and ERK were inhibited by LY294002, parthenolide and U0126, respectively, only LY294002 and parthenolide significantly inhibited the oleate induced PTX3 expression."

28489600

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➶

reach

"Pretreatment of cells with the inhibitor of Ikappa-Balpha degradation parthenolide prevented the CNIs elicited inflammatory response, suggesting regulation by NF-kappaB."

23958496

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➶

reach

"Investigating the molecular mechanisms by which parthenolide prevents iNOS/NO synthesis, we found that parthenolide inhibits the activation of p42/44 mitogen activated protein kinase (MAPK), but not IkBalpha (IkappaBalpha) degradation or nuclear factor-kappaB (NF-kappaB) p65 activation."

12417429

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➶

reach

"Parthenolide has been shown to inhibit NF-kappaB activity by preventing the breakdown of IkappaB-alpha and IkappaB-beta, both of which are responsible for the sequestration of NF-kappaB to the cytoplasm [18-24]."

28782644

Paracetamol affects IFNB1

| 4

Paracetamol inhibits IFNB1. 4 / 4

| 4

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➶

reach

"Previous studies have shown that HP-PRRSV-nsp4 inhibits IFN-I production induced by poly (I : C) and the catalytic triad His39-Asp64-Ser118 is essential for nsp4 to block IFN-beta production."

| PMC

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➶

reach

"Based on the results, we conclude that the intact catalytic triad of TGEV PL1 is required to inhibit activation of the IFN-β promoter driven by STING and TBK-1."

29201911

---

➶

reach

"Based on the results, we conclude that the intact catalytic triad of TGEV PL1 is required to inhibit activation of the IFN-beta promoter driven by STING and TBK-1."

29201911

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➶

reach

"As such, APAP is more likely to lower the efficacy of IFN-beta treatment as opposed to abrogate a desired endpoint."

20544007

Paclitaxel affects NFKBIA

| 4

Paclitaxel inhibits NFKBIA. 4 / 4

| 4

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➶

reach

"When compared to the background loss of IkappaBalpha in a 4-h period, TNF-alpha or taxol caused the degradation of IkappaBalpha by ~ 40% (XREF_FIG)."

19732770

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➶

reach

"Both TNF-alpha and taxol induce the degradation of endogenous IkappaBalpha and either taxol or TNF-alpha induction of NF-kappaB activity was blocked by inhibitors of NF-kappaB acting at different sites in the signaling pathway."

19732770

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➶

reach

"TNF-alpha and taxol induce degradation of IkappaBalpha."

19732770

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➶

reach

"Consistent with endogenous activation of NF-kappaB signaling by taxol we showed that, similar to TNF-alpha, taxol treatment in the presence of cycloheximide significantly reduced IkappaBalpha suggesting that both molecules induce proteasomal degradation of IkappaBalpha."

19732770

Ozone affects NFKBIA

| 4

Ozone inhibits NFKBIA. 4 / 4

| 4

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➶

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"Consistent with this observation, the antioxidant GSH-ET supplementation significantly inhibited ozone induced IkappaBalpha degradation (NFkappaB activation) in BEAS-2B cells (XREF_FIG)."

21621609

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➶

reach

"As shown in XREF_FIG, in the cells expressing scrambled shRNA, ozone exposure induced marked IkappaBalpha degradation."

21621609

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➶

reach

"Supplementation of antioxidant GSH blocks ozone induced IkappaBalpha degradation (NFkappaB activation) and IL-8 production and; 3.)"

21621609

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➶

reach

"First, ozone challenge causes IkappaBalpha degradation (NFkappaB activation)."

21621609

Olmesartan affects MAP3K7

| 4

Olmesartan inhibits MAP3K7. 4 / 4

| 4

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➶

reach

"Moreover, Olmesartan reduced the level of transforming growth factor beta activated kinase-1 (TAK1) and phospho-p38MAPK."

26706286

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➶

reach

"We may partially demonstrate the beneficial role of Olmesartan on patients with late-stage heart failure although we did not compare the role of Olmesartan and that of other sartans in the overload-pressure mice.Our data show Olmesartan blocked TAK1 kinase activity."

26706286

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➶

reach

"In neonatal rat cardiac fibroblast cells and cardiomyocytes, Olmesartan also decreased TAK1 and p38MAPK activation triggered by TGFbeta1 or AngII."

26706286

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➶

reach

"Taken together, our data suggested Olmesartan reduced phosphor-TAK1 and p38, which is involved in cardiac apoptosis and remodeling in the setting of stress."

26706286

Oligonucleotide affects RELA

| 4

Oligonucleotide inhibits RELA. 4 / 4

| 4

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➶

sparser

"Specifically, the NF- κ B p65 subunit seems to be an important regulator in intestinal inflammation in inflammatory bowel disease; in fact, treatment with antisense or decoy oligonucleotides that inhibit p65 has been shown to ameliorate the macroscopic signs of colitis as well as the nuclear accumulation and DNA binding activity of p65 protein in several models of intestinal inflammation [ xref – xref ]."

23346196

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➶

sparser

"Specifically, the NF- κ B p65 subunit seems to be an important regulator in intestinal inflammation in inflammatory bowel disease; in fact, treatment with antisense or decoy oligonucleotides that inhibit p65 has been shown to ameliorate the macroscopic signs of colitis as well as the nuclear accumulation and DNA binding activity of p65 protein in several models of intestinal inflammation [ xref – xref ]."

23346196

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➶

sparser

"Indeed, disease activity in mice with colitis is inhibited by antisense oligonucleotides that inhibit the p65 subunit of NF- κ B, which suggests a critical role for NF- κ B in mediating the inflammatory response [ xref ]."

26075036

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➶

sparser

"Indeed, disease activity in mice with colitis is inhibited by antisense oligonucleotides that inhibit the p65 subunit of NF- κ B, which suggests a critical role for NF- κ B in mediating the inflammatory response [ xref ]."

26075036

Nitric oxide affects NFKBIA

| 1 3

Nitric oxide inhibits NFKBIA. 4 / 4

| 1 3

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➶

reach

"Although we observed a potent inhibition of NO on IkappaBalpha degradation by purified proteasome, only partial inhibition of cellular IkappaBalpha degradation by NO was measured."

10393859

---

➶

medscan

"These data suggest that nitric oxide prevents sustained hyperoxia-induced degradation of IκBα and that nitric oxide may inhibit hyperoxia-induced NF-κB activation by stabilizing the inhibitory protein IκBα."

20805787

---

➶

reach

"The results showed that NO induced the degradation of IkappaB-alpha in the cytosol and translocation of NF-kappaB to the nucleus in HEI-OC1 cells."

23028481

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➶

reach

"To determine the mechanism of Resveratrol mediated inhibition of apoptosis and NF-kappaB activation, chondrocytes were treated with SNP (1 mM) and Resveratrol (20 muM) for 24 h. Western blotting showed that NO induced IkappaB-alpha degradation, Pro-caspase-3 and caspase-3 expression, and these effects were abrogated by Resveratrol (XREF_FIG A)."

24244824

Nitric oxide affects EIF2AK1

1 | 3

Nitric oxide inhibits EIF2AK1. 4 / 4

1 | 3

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➶

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"NO acts as an activator of HRI and CO serves as a suppressor of NO induced HRI activation XREF_BIBR."

27633668

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➶

reach

"NO acts as an activator of HRI [XREF_BIBR, XREF_BIBR, XREF_BIBR], while CO serves as a suppressor of NO induced HRI activation [XREF_BIBR]."

29065505

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➶

reach

"It was proposed that NO * reverses Hg 2+ inhibited HRI by nitrosylating Cys409, likely to form a thiol adduct, S-NO in active site (XREF_FIG)."

21463677

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➶

ctd

No evidence text available

17689536

Nedocromil affects ITCH

| 4

Nedocromil inhibits ITCH. 4 / 4

| 4

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"In addition, creams containing local anesthetics [XREF_BIBR], capsaicin, doxepin [XREF_BIBR], strontium nitrate [XREF_BIBR], or nedocromil sodium [XREF_BIBR] can be helpful to relieve itch."

26064156

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➶

reach

"In study 1, nedocromil sodium, frusemide and bumetanide reduced itch scores by 36%, 48% and 34%, respectively, and flare areas by 17%, 26% and 15% respectively (all P < 0.05)."

15005740

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➶

reach

"The results showed that nedocromil sodium reduced itch scores, totalled over 5 min, by approximately 74.0% (P < 0.005) and flare areas by approximately 65% (P < 0.03)."

11159712

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➶

reach

"Further evidence pointing to a neuronal mechanism of action is the finding that the iontophoretic application of nedocromil to human skin inhibited itch and the flare response to intradermal administration of histamine, and this inhibitory effect was not attributable to mast cell stabilization nor to H 1 -receptor antagonism [166]."

12657498

Morphine(1+) affects TRAF6

| 1 3

Morphine(1+) inhibits TRAF6. 4 / 4

| 1 3

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sparser

"Morphine inhibits p65 and TRAF6 through miR-124."

25539811

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➶

reach

"Therefore, our data suggest that miR-124 is required for morphine mediated inhibition of p65 and TRAF6."

25539811

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➶

reach

"Morphine inhibits p65 and TRAF6 through miR-124."

25539811

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➶

reach

"This is supported by the immunoblot result that morphine down-regulated proteins TRAF6 and p65 both in vitro and in vivo, suggesting that long-term morphine exposure attenuates the immune function of microglia in the CNS."

25539811

Metformin affects CASP1

| 4

Metformin inhibits CASP1. 4 / 4

| 4

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reach

"Lee, H. M et al. found that metformin could inhibit IL-1beta and caspase-1 through activation of the AMPK pathway [30]."

30269815

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➶

reach

"In our study, we observed that Metformin significantly suppressed accumulation of the NLRP3 inflammasome and activation of Caspase-1."

32330868

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➶

reach

"Immunohistochemical staining, immunofluorescence staining and western blot assays indicated that the expression levels of mTOR, NLRP3, caspase-1, IL-1beta and GSDMD-N were decreased in the diabetic model treated with metformin and were reversed after the administration of an AMPK inhibitor in vivo and in vitro."

31182921

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➶

reach

"Lee et al. [XREF_BIBR] showed that levels of IL-1beta maturation and caspase-1 cleavage are decreased in monocyte derived macrophages from T2DM patients treated with metformin, an anti-diabetic drug."

24064574

Mangiferin affects NLRP3

| 4

Mangiferin inhibits NLRP3. 4 / 4

| 4

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➶

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"Mangiferin inhibits hippocampal NLRP3 inflammasome and exerts antidepressant effects in a chronic mild stress mice model."

28410265

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➶

reach

"Recent studies have shown that Mangiferin inhibits NLRP3 inflammasome in liver and endothelial cells to protect against liver injury and endothelial dysfunction XREF_BIBR XREF_BIBR."

28218280

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➶

reach

"Moreover, Mangiferin restored insulin mediated Akt and eNOS phosphorylations with increased NO production, immunohistochemistry examination of adipocytes, and endothelial tissue in high-fat diet fed mice also showed that oral administration of Mangiferin inhibited ER stress and NLRP3 induction in PVAT, and then effectively prevented insulin resistance in the vessel endothelium."

28349253

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➶

reach

"In conclusion, mangiferin protected against LPS and GalN induced liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation."

26668000

Luteolin affects MAPK8

1 | 3

Luteolin inhibits MAPK8. 4 / 4

1 | 3

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"In vitro kinase assay data shows that JNK1 activity was significantly suppressed by luteolin, but there was no significant change in JNK2 activity (XREF_FIG A and B)."

23551430

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➶

reach

"Our in vitro kinase assay results indicate that luteolin significantly inhibits JNK1 and p90RSK2 activity, but not that of JNK2 and ERK2."

23551430

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➶

ctd

No evidence text available

10718847

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➶

reach

"In vitro kinase assay data revealed that luteolin significantly suppressed JNK1 and p90RSK activity, but not that of JNK2 and ERK2."

23551430

Lithium chloride affects RELA

| 4

Lithium chloride inhibits RELA. 4 / 4

| 4

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➶

reach

"Additionally, NF-kappaB and p65 immunofluorescence was attenuated by DAPT and LiCl; as opposed to this, IkappaBalpha protein expression was increased."

29049420

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➶

reach

"Moreover, LiCl also inhibited NF-kappaB p65 transactivation induced by MDP, suggesting that GSK-3beta activity is required for NF-kappaB and IL-8 activation downstream of Nod2 activation."

18243161

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➶

reach

"While stimulus withdrawal in the presence of pentoxifylline or lithium chloride did not prevent depletion of RelA from the nucleus, depletion of c-Rel was partially inhibited (XREF_FIG)."

22860011

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➶

reach

"Immunohistochemical results indicated that p65 expression was reduced when treated with LiCl in vivo."

29137395

Lithium chloride affects IFNB1

| 4

Lithium chloride inhibits IFNB1. 4 / 4

| 4

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➶

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"The ability of the lithium to inhibit IFN-beta production was confirmed in vivo, as mice treated with lithium chloride exhibited decreased levels of IFN-beta upon Sendai virus infection."

24043902

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➶

reach

"Moreover, it seems that IFN-beta inhibition induced by LiCl in immune cells also apply to other virus or stimuli."

32205210

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➶

reach

"In this study, we show that lithium chloride attenuates LPS-, polyinosinic-polycytidylic acid-, and Sendai virus induced IFN-beta production and IFN regulatory factor 3 activation in macrophages in a glycogen synthase kinase-3beta-independent manner."

24043902

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➶

reach

"Moreover, it seems that IFN-β inhibition induced by LiCl in immune cells also apply to other virus or stimuli."

32205210

Lansoprazole affects IRF7

| 1 3

Lansoprazole inhibits IRF7. 4 / 4

| 1 3

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➶

eidos

"Objective In the present study , we hypothesize that lansoprazole has the potential to suppress IRF7 activity and prevent corticosteroid-induced ONFH in rats ."

31938894

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➶

reach

"In rats, co-treatment of lansoprazole with corticosteroids significantly repressed both IRF7 activity and the development of ONFH."

31938894

---

➶

reach

"In rats, co-treatment of lansoprazole with corticosteroids significantly repressed both IRF7 activity and the development of ONFH."

31938894

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➶

reach

"Results In rats, co-treatment of lansoprazole with corticosteroids significantly repressed both IRF7 activity and the development of ONFH."

31938894

Isotretinoin affects FOS

2 | 2

Isotretinoin inhibits FOS. 4 / 4

2 | 2

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➶

ctd

No evidence text available

19066126

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➶

reach

"Retinoic acid treatment of PKCalpha-MDA-MB-231 cells decreased proliferation (by approximately 40%) and inhibited serum activation of MAP kinases and induction of c-fos."

11525643

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➶

reach

"In addition, we show that IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate transiently induce c-jun and c-fos expression and that retinoic acid inhibits IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate induction of c-fos, but not c-jun."

2178224

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➶

ctd

No evidence text available

18652567

Isoflurane affects RELA

| 4

Isoflurane inhibits RELA. 4 / 4

| 4

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"Isoflurane pretreatment significantly abolished tPA activated NF-kappaBp65 with conditions of OGD/R."

28539818

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➶

reach

"LPS stimulation led to nuclear translocation of NF-kappaB p65 subunit, which was blocked by 100% oxygen or 0.5 MAC isoflurane in 60% oxygen."

28345549

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➶

reach

"In human PBMCs stimulated by plasma from septic patients, plasma from septic patients also led to nuclear translocation of NF-kappaB p65 subunit, which was also blocked by 100% oxygen or 0.5 MAC isoflurane in 60% oxygen [XREF_FIG]."

28345549

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➶

reach

"IL-1beta, 16.6 vs. 55.7 pg/ml, all P < 0.05) [XREF_FIG], and LPS stimulation also induced the nuclear translocation of NF-kappaB p65 subunit, which was blocked by 100% oxygen or 0.5 MAC isoflurane in 60% oxygen [XREF_FIG]."

28345549

Inositol affects CASP1

| 4

Inositol inhibits CASP1. 4 / 4

| 4

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➶

reach

"Here, a model integrates both biochemical and cellular data to provide a more quantitative estimation of MI inhibition of CA/SP1 cleavage, and thus formation of mature viruses in vivo."

27893830

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➶

reach

"In seeking the mechanistic origins of this behavior we initially considered a simplified model for MI inhibition of CA/SP1 cleavage of viral particles in which cleavage only takes place in that fraction of particles not bound to the MI."

27893830

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➶

reach

"To complete the data required to model MI inhibition of CA/SP1 cleavage (XREF_FIG) as a function of MI and Gag polymorph, specific binding affinities of BVM, BMS-1 and BMS-955176 toward VLPs containing Gag polymorphs were determined through the use of a competitive radioligand binding assay (XREF_TABLE)."

27893830

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➶

reach

"Since it has been also documented that acute MI increased caspase-1 activity and formation of inflammasome [XREF_BIBR], decreased miR-1 during MI might be an unappreciated propyroptosis mechanism by which the synthesis of inflammasome components is enhanced contributing to the development of pyroptosis."

26491223

Imipramine affects FOS

| 4

Imipramine inhibits FOS. 4 / 4

| 4

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➶

reach

"However, the dual NET-SERT inhibitor imipramine, which is also less effective at promoting sleep than other TCAs, decreases c-Fos in the LC [XREF_BIBR]."

19833104

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➶

reach

"The imipramine increased c-Fos immunoreactivity was suppressed in the mPFC of rats repeatedly treated with ACTH."

23922220

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➶

reach

"Imipramine decreased c-Fos in the basolateral amygdala and hippocampus (CA1 and CA3), but increased c-Fos in the central amygdala."

28866130

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➶

reach

"In addition, c-fos induction in response to acute restraint stress was down-regulated by chronic, but not acute, administration of tranylcypromine or imipramine, two drugs that nonselectively increase synaptic levels of norepinephrine and serotonin by inhibition of monoamine oxidase or neurotransmitter reuptake, respectively."

7612155

Ibuprofen affects CHUK

1 | 3

Ibuprofen inhibits CHUK. 4 / 4

1 | 3

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➶

reach

"The anti-inflammatory agent, ibuprofen, has been shown to inhibit constitutive activation of NF-kappaB and IKKalpha in prostate cancer cells (Palayoor et al, 1999), and when combined with megestrol acetate produced an increase in body weight in gastrointestinal cancer patients (McMillan et al, 1999), while megestrol acetate alone produced a decrease in body weight."

15477867

---

➶

ctd

No evidence text available

10602496

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➶

reach

"The anti-inflammatory agent ibuprofen inhibited the constitutive activation of NF-kappaB and IKKalpha in PC-3 and DU-145 cells, and blocked stimulated activation of NF-kappaB in LNCaP cells."

10602496

---

➶

reach

"Ibuprofen has been shown to inhibit the constitutive activation of IKKalpha and NF-kappaB in androgen independent prostate tumor cells XREF_BIBR."

18694378

Hydroxychloroquine affects TLR7

| 4

Hydroxychloroquine inhibits TLR7. 4 / 4

| 4

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➶

reach

"Other Toll like targets are of interest as well, such as TLR-7 and TLR-9 blockage by hydroxychloroquine, which has been used successfully in inflammatory disorders such as systemic lupus erythematosus [XREF_BIBR] and post-Lyme 's arthritis [XREF_BIBR]."

24526250

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➶

reach

"This was also seen after removal of patients prescribed the glucocorticoid prednisone, which has been reported to inhibit NF-kappaB activation, and hydroxychloroquine (Plaquenil (R)) inhibiting TLR7 and -9 signaling."

30846988

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➶

reach

"A role of TLRs in HIV induced immune activation is also supported by the reduction in immune activation by TLR7 and TLR9 signaling inhibitors such as chloroquine and hydroxychloroquine [XREF_BIBR, XREF_BIBR]."

28829402

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➶

reach

"In rheumatoid arthritis and systemic lupus erythematosus, hydroxychloroquine has been suggested to mediate its anti-inflammatory action by inhibiting the activation of TLR7 and TLR9 that reside in endosomal/lysosomal compartments 23."

30002366

Glutathione affects PYCARD

| 4

Glutathione inhibits PYCARD. 4 / 4

| 4

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➶

reach

"High levels of GSH inhibited but did not completely block ASC oxidation."

24798334

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➶

reach

"It is generally accepted that GSH reduces dehydroascorbate (DHA) to give oxidized glutathione (GSSG) and ASC (2GSH+ DHA --> GSSG+ASC) as a chemical pathway of ascorbate regeneration."

20541006

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➶

reach

"Reduced glutathione (GSH) concentration increased more than ASC concentration under heat stress."

28579994

---

➶

reach

"Reduced glutathione (GSH) concentration increased more than ASC concentration under heat stress."

28579994

Glutathione affects NFKB1

| 4

Glutathione inhibits NFKB1. 4 / 4

| 4

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➶

reach

"In addition, physalin F suppressed NF-kappaB activity and nuclear translocation of p65 and p50, which was reversed by NAC and GSH."

22815798

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➶

reach

"APE1 and Ref -1 promotes GSH- or Trx mediated reduction of p50."

18586825

---

➶

reach

"Alternatively, APE1 and Ref -1 may promote GSH- or Trx mediated reduction of p50."

18586825

---

➶

reach

"These results indicate that independently of its cysteine residues, APE1 and Ref -1 promotes GSH- or Trx mediated reduction of p50."

18586825

Glutathione affects MAPK8

| 4

Glutathione inhibits MAPK8. 4 / 4

| 4

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➶

reach

"Free radical scavengers N-acetyl-L-cysteine (NAC), or glutathione (GSH), inhibited ERK2 activation and, to a much lesser extent, JNK1 activation by BHA and tBHQ, implicating the role of oxidative stress."

11768769

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➶

reach

"Free radical scavengers N-acetyl-L-cysteine (NAC), or glutathione (GSH), inhibited ERK2 activation and, to a much lesser extent, JNK1 activation by BHA and tBHQ, implicating the role of oxidative stress."

11768769

---

➶

reach

"Free radical scavengers N -acetyl cysteine (NAC) and glutathione (GSH) inhibited ERK2 activation and, to a much lesser extent, JNK1 activation by tBHQ ⧸ BHA, implicating the role of oxidative stress in tBHQ induced ARE activation."

15038973

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➶

reach

"Free radical scavengers N -acetyl cysteine (NAC) and glutathione (GSH) inhibited ERK2 activation and, to a much lesser extent, JNK1 activation by tBHQ ⧸ BHA, implicating the role of oxidative stress in tBHQ induced ARE activation."

15038973

Glucose affects JUN

| 1 3

Glucose inhibits JUN. 4 / 4

| 1 3

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➶

reach

"Loss and gain of DKK1 function modulated HG mediated c-Jun, TGF-beta1, and fibronectin expression."

20019166

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➶

medscan

"These results support our hypothesis that high glucose inhibits the c-Jun pathway and that IGFBP-3 can restore activity in the pathway to near normal levels."

25086184

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➶

reach

"Adiponectin suppresses the HG induced BeWo cell proliferation by inhibiting the activation of JNK and c-jun."

25031708

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➶

reach

"These results support our hypothesis that high glucose inhibits the c-Jun pathway and that IGFBP-3 can restore activity in the pathway to near normal levels."

25086184

Gallic acid affects RIPK1

| 4

Gallic acid inhibits RIPK1. 4 / 4

| 4

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➶

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"GA, an inhibitor of the heat shock protein 90 kDa (HSP90) XREF_BIBR, was known to downregulate the protein level of RIPK1 XREF_BIBR and therefore was expected to halt necroptosis."

22860037

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➶

reach

"Second, GA treatment causes degradation of RIP, resulting in the assembly of a TNF-R1 signaling complex lacking RIP and defective in IKK activation."

11864612

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➶

reach

"MG-132, a specific proteasome inhibitor, abrogated GA induced degradation of RIP but failed to restore the activation of IkappaB kinase by TNF, perhaps because, in the presence of GA and MG-132, RIP accumulated in a detergent-insoluble subcellular fraction."

10744744

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➶

reach

"Geldanamycin (GA), an antitumor of benzoquinone ansamycin (Stebbins et al., 1997), is an HSP-90 inhibitor and induces RIP degradation, followed by inhibition of NF-kappaB-mediated protection (Lewis et al., 2000)."

12493534

Fenfluramine affects FOS

| 4

Fenfluramine inhibits FOS. 4 / 4

| 4

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➶

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"Fenfluramine decreased c-fos immunoreactivity in diestrous females and increased it in pro and estrous females, while pCPA increased c-fos immunoreactivity during diestrus, and decreased it during pro and estrus (XREF_FIG)."

27657308

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➶

reach

"Absence of fenfluramine induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice."

9651234

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➶

reach

"In addition, pretreatment with the D (1) receptor antagonist SCH 23390 (0.5 mg/kg) also partially suppressed the induction of c-fos by fenfluramine."

19912927

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➶

reach

"Fenfluramine treated females in pro and estrus had qualitatively elevated c-fos immunoreactivity, while fenfluramine treated females in diestrus had decreased c-fos immunoreactivity relative to saline controls, although posthoc tests for each pairwise comparison were not individually significant (XREF_FIG)."

27657308

Ethanol affects STAT1

| 4

Ethanol inhibits STAT1. 4 / 4

| 4

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➶

reach

"Alcohol also inhibited IFN induced up-regulation of Stat1 at these concentrations."

16324217

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➶

reach

"As shown in Fig. 9, ethanol treatment decreased the pSTAT1 and STAT1 ratio in Hep G2 cells by 1.5-2-fold compared with untreated cells after 1 hr of IFNgamma exposure."

12948850

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➶

reach

"However, ethanol exposure suppressed STAT1 attachment to DNA (XREF_FIG)."

19195028

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➶

reach

"It appears that while STAT1 activity is abrogated by acute and chronic alcohol exposure, chronic alcohol enhances STAT3 and modulates alcohol induced steatosis and inflammation based on the cell-type in which it is expressed."

19398236

Ethanol affects PYCARD

| 2 2

Ethanol inhibits PYCARD. 4 / 4

| 2 2

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➶

medscan

"However, the exact mechanism by which ethanol inhibits the ASC oligomerization remains to be elucidated."

24244322

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➶

reach

"Ethanol Inhibits Secretion and Oligomerization of ASC."

24244322

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➶

reach

"Here were demonstrated that ethanol significantly inhibited the secretion of ASC in nigericin activated macrophages (XREF_FIG)."

24244322

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➶

medscan

"Ethanol conferred the inhibitory functions by attenuating the disruption of lysosomal integrity and ensuing leakage of the lysosomal protease cathepsin B and by reducing oligomerization of ASC."

24244322

Estrogen affects NLRP3

| 4

Estrogen inhibits NLRP3. 4 / 4

| 4

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➶

reach

"This study was performed to identify whether NLRP3 inflammasome can be triggered by lipopolysaccharides (LPS) and adenosine triphos adenine (ATP), which are positively related with knee OA severity in joint-spaces, in human fibroblast like synoviocytes (FLS), and to identify whether estrogen would inhibit the activation of NLRP3 inflammasome."

29105345

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➶

reach

"Emerging evidence has shown that estrogen can act as an inflammatory protective factor to suppress NLRP3 mediated neuroinflammation in the hippocampus."

32613145

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➶

reach

"These results indicated that melatonin ameliorates estrogen deficiency induced osteoporosis and impaired osteogenic differentiation potential by suppressing activation of the NLRP3 inflammasome via mediating the Wnt and beta-catenin pathway."

29804160

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➶

reach

"But in the brain and in fibroblast like synoviocytes, estrogen inhibits activation of the NLRP3 inflammasome."

32613145

Erlotinib affects RELA

| 4

Erlotinib inhibits RELA. 4 / 4

| 4

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"In contrast, erlotinib treatment decreased pERK, pAKT and pRelA and increased the levels of cleaved Parp only upon AXL knockdown in the ER1 and ER2 cell lines (XREF_FIG)."

22751098

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➶

reach

"As expected, we found that erlotinib treatment decreased pERK, pAKT and pRelA (a marker of NF-kB signaling) and increased Parp cleavage (a marker of apoptosis) in parental HCC827 cells (XREF_FIG)."

22751098

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➶

reach

"Erlotinib treatment for 48h decreased pAKT, pERK, and pRelA and increased Parp cleavage in sensitive tumors (a marker of apoptosis) (XREF_FIG) but pAKT, pERK, pRelA levels were maintained in each tumor with acquired erlotinib resistance (XREF_FIG)."

22751098

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➶

reach

"Both erlotinib and EGCG or their combination failed to inhibit p65 and Bcl-2 in M4e cells (XREF_FIG)."

19470788

Emodin affects NLRP3

| 4

Emodin inhibits NLRP3. 4 / 4

| 4

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➶

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"In this study, we hypothesized that emodin inhibited NLRP3 inflammasome activation via Nrf2 signaling."

32546964

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➶

reach

"Furthermore, emodin inhibited the P2X7 and NLRP3 signaling pathway followed by the decrease of pro inflammatory factors, and the latter is beneficial for the recovery of SAP."

30542707

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➶

reach

"Although the detailed mechanisms that link the common molecular pathways to the means by which emodin attenuates NLRP3 inflammasome activation remains to be elucidated, this is the first report providing scientific evidence substantiating the use of emodin in medicine for the treatment of various inflammatory diseases through the regulation of inflammasome activation, which may provide a valuable therapeutic strategy for controlling inflammasome mediated pathological conditions."

25867480

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➶

reach

"Taken together, our study showed that emodin inhibited NLRP3 inflammasome activation in vitro and LPS induced endotoxin shock in in vivo model."

25867480

Double-stranded RNA affects IRF3

| 4

Double-stranded RNA inhibits IRF3. 4 / 4

| 4

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➶

reach

"By binding to dsRNA NS1 disguises the viral dsRNA pattern from the cytoplasmic receptors and inhibits IFN-α/INF-β induction via IRF3 (Garcia-Sastre, 2004; Talon et al., 2000)."

18086372

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➶

reach

"By binding to dsRNA NS1 disguises the viral dsRNA pattern from the cytoplasmic receptors and inhibits IFN-a/INF-b induction via IRF3 (Garcia-Sastre, 2004; Talon et al., 2000) ."

18086372

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➶

reach

"Previous studies have shown that PRRSV nsp1α/β modulates type I IFN response by blocking dsRNA-induced IRF-3 activation and IFN promoter activities, but IRF-3 phosphorylation and its nuclear translocation occur normally in the presence of the nsp1α/β [51]."

24967365

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➶

reach

"Previous studies have shown that PRRSV nsp1 / modulates type I IFN response by blocking dsRNA-induced IRF-3 activation and IFN promoter activities, but IRF-3 phosphorylation and its nuclear translocation occur normally in the presence of the nsp1 / [51] ."

24967365

Double-stranded RNA affects DDX58

| 4

Double-stranded RNA inhibits DDX58. 4 / 4

| 4

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➶

reach

"This activity enables the NP from Lassa virus to digest free dsRNA, which prevents the activation of RIG-I 66, 67 ."

27174148

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➶

reach

"Both dsRNA and PACT can activate RIG-I while VP35 inhibits RIG-I in a dose-dependent manner in both activation scenarios, which the authors have suggested that VP35 blocks RIG-I both by shielding dsRNA from detection and by preventing PACT binding to RIG-I [7]."

28977821

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➶

reach

"Using a luciferase reporter gene assay, we first 442 evaluated VP35-WT and VP35-S129A inhibition of dsRNA-induced RIG-I activation of the IFN-β 443promoter."

| DOI

---

➶

reach

"Both dsRNA and PACT can activate Editorial www.impactjournals.com/oncotarget RIG-I while VP35 inhibits RIG-I in a dose-dependent manner in both activation scenarios, which the authors have suggested that VP35 blocks RIG-I both by shielding dsRNA from detection and by preventing PACT binding to RIG-I [7] ."

28977821

Dihydroartemisinin affects RELA

| 2 2

Dihydroartemisinin inhibits RELA. 4 / 4

| 2 2

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"As shown in Figure XREF_FIG A, DHA remarkably suppressed nuclear NF-kappaB subunit p65 (also known as RelA) expression, while EPA, LA, and AA had no effect when compared to the IL-6-stimulated group."

25881314

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sparser

"In addition, DHA inhibited nuclear p65 ( ∗ p < 0.05) ( xref ) and significantly promoted TNF- α and TRAF6 ( ∗ p < 0.05) expression with time (Figures xref and xref )."

31534470

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➶

reach

"DHA inhibited TNF-alpha-stimulated NF-kappaB signaling, confirmed by Western blotting for IkappaB-alpha and p-p65, as well as p65 immunofluorescence."

27941926

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➶

sparser

"In addition, DHA inhibited nuclear p65 ( ∗ p < 0.05) ( xref ) and significantly promoted TNF- α and TRAF6 ( ∗ p < 0.05) expression with time (Figures xref and xref )."

31534470

Dihydroartemisinin affects NFKBIA

| 4

Dihydroartemisinin inhibits NFKBIA. 4 / 4

| 4

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"Taken together, these results revealed that DHA, more efficiently than EPA, inhibited the protein degradation by regulating IkappaBalpha and NFkappaB signaling pathway in C2C12 myotubes by activating PPARgamma gene expression."

23984342

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➶

reach

"We discovered that DHA directly inhibits IkappaBalpha kinase beta (IKKbeta) and IKKalpha enzymatic activity in vitro, whereas AA did not have this effect."

15254232

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➶

reach

"The aim of this study was to investigate whether DHA can more efficiently inhibit protein degradation than EPA by regulating IkappaBalpha and NFkappaB pathway in C2C12 myotubes in a PPARgamma dependent manner."

23984342

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➶

reach

"Stimulation with EPA or AA, but not DHA, inhibited IL-1beta induced breakdown of IkappaBalpha significantly (p < 0.05) compared to treatment with IL-1beta alone."

23849180

Dihydroartemisinin affects NFKB1

| 4

Dihydroartemisinin inhibits NFKB1. 4 / 4

| 4

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"Singer et al., suggested that EPA and DHA could inhibit NFKB activity at several levels during NF-kappaB pathway [XREF_BIBR]."

27044314

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➶

reach

"DHA also increases lipoxins, inhibits NFkb, and produces neuroprotectin-D and resolvins, which are important for complete resolution of the inflammatory process [XREF_BIBR]; it is important to underline that the incomplete resolution of an inflammatory response can be a significant contributor to chronic and exacerbating disease and pain development."

25097659

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➶

reach

"DHA, with targeting lipopolysaccharides (LPS) surface receptor, suppresses NFkB activity and the production of inflammatory cytokines in microglia."

29736227

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➶

reach

"The epoxides of both EPA and DHA, formed by the action of CYP enzymes, also inhibit NFkB inflammatory signaling via PPAR activation."

23833568

Diarsenic trioxide affects RELA

4 |

Diarsenic trioxide inhibits RELA. 4 / 4

4 |

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ctd

No evidence text available

20471514

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➶

ctd

No evidence text available

16105982

---

➶

ctd

No evidence text available

20534739

---

➶

ctd

No evidence text available

16174796

Dexamethasone affects RELA

1 | 3

Dexamethasone inhibits RELA. 4 / 4

1 | 3

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➶

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"Our current findings clearly indicate that dexamethasone pretreatment inhibits IL-1beta-induced NF-kappaB and p65 activation in the prostate (XREF_FIG) and stops the translocation of NF-kappaB subunits to the nucleus (XREF_FIG)."

19170127

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➶

reach

"Dexamethasone decreased NF-kappaB p65 activity."

28978062

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ctd

No evidence text available

10467400

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➶

reach

"Phosphorylation of NF-kappaB p65 was significantly reduced in mice treated with triptolide and dexamethasone."

25466609

Cytosine affects CASP1

| 4

Cytosine inhibits CASP1. 4 / 4

| 4

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"Western blot analysis indicates that LPS treatment induced degradation of caspase-1 precursor, which was inhibited by treatment CYT or quercetin."

21108840

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➶

reach

"To determine if CYT or quercetin inhibits caspase-1 activation induced by LPS, cells were exposed to LPS in the presence or absence of CYT (1 mg/ml) or quercetin (0.1 mM)."

21108840

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➶

reach

"In conclusion, we suggest that CYT and quercetin decrease LPS induced inflammatory cytokine production by inhibiting NF-kappaB and caspase-1 activation."

21108840

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➶

reach

"CYT and quercetin also inhibited IL-32 production and caspase-1 activation."

21108840

Curcumin affects MYD88

| 4

Curcumin inhibits MYD88. 4 / 4

| 4

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"Therefore, curcumin inhibits LPS induced activation of both MyD88- and TRIF dependent pathways of TLR4 resulting in the inhibition of both NF-kappaB and IRF3."

16678799

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➶

reach

"Curcumin also markedly inhibited the upregulation of toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), phosphorylation level of IkappaB-alpha, and activation of NF-kappaB in PMA induced macrophages."

27777559

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➶

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"It has been shown that curcumin inhibits not only the IkappaB kinase (IKK) beta in the MyD88 signaling pathway but also the MyD88 independent pathway upstream of Toll and IL-1R domain containing adaptor inducing IFN-beta (TRIF)."

24188011

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➶

reach

"Additionally, MYD88, NLRC4 and TXNIP were downregulated by curcumin."

24431405

Cisplatin affects IKBKB

| 4

Cisplatin inhibits IKBKB. 4 / 4

| 4

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"HN13 cells were sensitized to 5mug/ml of cisplatin following suppression of IKKalpha and IKKbeta compared to 12.5 mug/ml of cisplatin when transfected with scramble siRNA (XREF_FIG A lower panel)."

24490130

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➶

reach

"We do not know if the increased sensitivity to cisplatin following suppression of IKKalpha and IKKbeta was a direct effect of low levels of NFkappaB or a consequence of chromatin acetylation induced by siRNA interference of the NFkappaB signaling."

24490130

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➶

reach

"Following suppression of IKKalpha and IKKbeta with siRNA, HN13 cells were treated with TSA, cisplatin, or vehicle and lysed."

24490130

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➶

reach

"Following knockdown of IKKalpha and IKKbeta, HN13 cells were treated with cisplatin (5 mug/ml) and stained with Hoechst 33342."

24490130

Cisplatin affects CHUK

| 4

Cisplatin inhibits CHUK. 4 / 4

| 4

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"HN13 cells were sensitized to 5mug/ml of cisplatin following suppression of IKKalpha and IKKbeta compared to 12.5 mug/ml of cisplatin when transfected with scramble siRNA (XREF_FIG A lower panel)."

24490130

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➶

reach

"We do not know if the increased sensitivity to cisplatin following suppression of IKKalpha and IKKbeta was a direct effect of low levels of NFkappaB or a consequence of chromatin acetylation induced by siRNA interference of the NFkappaB signaling."

24490130

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➶

reach

"Following knockdown of IKKalpha and IKKbeta, HN13 cells were treated with cisplatin (5 mug/ml) and stained with Hoechst 33342."

24490130

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➶

reach

"Following suppression of IKKalpha and IKKbeta with siRNA, HN13 cells were treated with TSA, cisplatin, or vehicle and lysed."

24490130

Cis-doxepin affects ITCH

| 4

Cis-doxepin inhibits ITCH. 4 / 4

| 4

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"45 Only topical doxepin, a tricyclic antidepressant and potent H1 and H2 antagonist, has been shown to significantly reduce pruritus in patients with AD, lichen simplex chronicus, contact dermatitis and nummular dermatitis."

21767774

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➶

reach

"In addition, creams containing local anesthetics [XREF_BIBR], capsaicin, doxepin [XREF_BIBR], strontium nitrate [XREF_BIBR], or nedocromil sodium [XREF_BIBR] can be helpful to relieve itch."

26064156

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➶

reach

"The change in itch intensity (VAS) was not different during the doxepin and placebo period (p = 0.994); neither the doxepin cream nor placebo cream reduced itch intensity."

31839501

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➶

reach

"Only topical doxepin was shown to provide some relief (2 ~ 3 hours duration), but did not effectively relieve nightly bouts of itch."

26848223

Cholesterol affects NLRP3

| 4

Cholesterol inhibits NLRP3. 4 / 4

| 4

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➶

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"We speculate that as well as triggering AIM2 and NLRP3, loss of cholesterol metabolic homeostasis activates still to be defined HAMP sensors."

30172069

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➶

reach

"Conversely, induction of cholesterol efflux from myeloid cells inhibits NLRP3 inflammasome activation 73."

30846875

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➶

reach

"Taken together, these results indicate that lysosomal cholesterol accumulation can decrease LMP, NLRP3 inflammasome activation, and IL-1beta release."

25054161

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➶

reach

"In agreement, acute depletion of the ER cholesterol pool by statin treatment abrogated the assembly and activation of the NLRP3 inflammasome."

30054450

Chloroquine affects STING1

| 4

Chloroquine inhibits STING1. 4 / 4

| 4

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"Brefeldin A, but not chloroquine, blocked STING trafficking, indicating that STING locates from the ER via the Golgi to vesicles in the perinuclear region (XREF_SUPPLEMENTARY)."

19776740

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➶

reach

"Chloroquine, which inhibits the lysosomal degradation pathway, could only partially block the degradation of MITA [72], suggesting MITA is mostly degraded by a non-lysosomal degradation pathway."

24929887

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➶

reach

"Degradation of STING occurred in the lysosomal compartment since chloroquine, which inhibits lysosomal degradation, prevented STING degradation (XREF_SUPPLEMENTARY)."

24119841

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➶

reach

"Chloroquine, a lysosomal inhibitor which reportedly prevents STING degradation, did not block STING trafficking, confirming that STING degradation occurs after translocation (XREF_FIG)."

28763789

Celastrol affects RELA

| 4

Celastrol inhibits RELA. 4 / 4

| 4

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➶

reach

"It was observed that celastrol suppressed constitutively p65 and IKK, which may led to the inhibition of phosphorylation of p65 and IkBa, respectively XREF_BIBR."

24755677

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➶

reach

"Nevertheless, celastrol reversed the decrease of cytoplasmic p65 protein and the increase of nuclear p65 protein induced by AOM and DSS."

26793111

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➶

reach

"Pre-loading celastrol for 30 min could inhibit the actions of MEK1, ERK1, NF-kappaB (p65), and STAT1, but not p38 (XREF_FIG)."

25116125

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➶

reach

"Celastrol also inhibited poly (I : C)-induced p65 DNA binding activity, as determined by EMSA (XREF_FIG)."

28027722

Celastrol affects MAP3K7

| 2 2

Celastrol inhibits MAP3K7. 4 / 4

| 2 2

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➶

reach

"Celastrol, used as an anti-inflammatory drug in traditional Chinese medicine, 32 has been shown to inhibit TAK1."

22641218

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➶

medscan

"As celastrol inhibits TAK1-mediated Nuclear Factor-κB activation, and promotes apoptosis in head and neck squamous cell carcinoma cells, the alternative TAK1-Nuclear Factor-κB pathway could serve as a potential drug target for developing effective therapies to treat head and neck squamous cell carcinoma."

22641218

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➶

medscan

"Finally, inhibition of TAK1 by celastrol inhibited vGPCR-induced NF-κB activation, indicating this natural compound could be used as a potential therapeutic drug against Kaposi's sarcoma-associated herpesvirus malignancies involving vGPCR."

21159881

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➶

reach

"Celastrol 2.5 muM could also reduce p-TAK1 and p-p65 over 1-2 hours, without reducing total TAK1 (XREF_SUPPLEMENTARY)."

22641218

Celastrol affects IKBKB

| 1 3

Celastrol inhibits IKBKB. 4 / 4

| 1 3

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➶

reach

"This study determines the neuroprotective and inhibitory effect of celastrol on amyloid beta 1-42 (Abeta 1-42) induced cytotoxicity and IKKbeta activity, respectively."

27931154

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➶

reach

"Inhibition of IKKbeta by celastrol and its analogues - an in silico and in vitro approach."

27931154

---

➶

medscan

"Inhibition of IKKβ by celastrol and its analogues - an in silico and in vitro approach."

27931154

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➶

reach

"Celastrol is a quinone methide triterpene inhibiting directly kinases IKKalpha and IKKbeta and inactivates CDC37 (cell division cycle 37) and p23 (prostaglandin E synthase 3) proteins and is thus an HSP90 (heat-shock protein 90 kDa) inhibitor."

26775695

Carbon monoxide affects RELA

| 4

Carbon monoxide inhibits RELA. 4 / 4

| 4

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➶

reach

"CO donors induce Nrf2 activation and Nrf2 siRNA suppresses CO-induced p65 glutathionylation and inhibition."

24512908

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➶

reach

"XREF_BIBR, XREF_BIBR Moreover, CO inhibits vascular inflammation by interfering with the IKK dependent signaling pathway or by stimulating S glutathiolation of the NF-kappaB p65 subunit."

29170479

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➶

reach

"The generated CO effectively suppresses the secretion of interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha by inhibiting cell proliferation; inducing the activation of heme oxygenase (HO-1), and downregulating the expression of p38 MAPK, NF-kB (p50 and p65) and TLR-2."

32554130

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➶

reach

"Additionally, we observed that CO reduced the activation of transcription nuclear factor-kappaB p65 in DSS treated colon tissues."

21598422

Brefeldin A affects STING1

| 4

Brefeldin A inhibits STING1. 4 / 4

| 4

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➶

reach

"First, Brefeldin A, known to cause disassembly of the Golgi complex XREF_BIBR, blocked MITA trafficking, indicating that Golgi apparatuses are involved in the translocation of MITA."

24929887

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➶

reach

"First, Brefeldin A, known to cause disassembly of the Golgi complex [66], blocked MITA trafficking, indicating that Golgi apparatuses are involved in the translocation of MITA."

24929887

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➶

reach

"Another V-ATPase inhibitor Concanamycin A (ConA) also blocked STING degradation, while Brefeldin A (BFA, blocks ER exit) blocked STING activation (no slower migrating band) and degradation (XREF_FIG, substantial STING degradation is not expected in the absent of trafficking)."

29241549

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➶

reach

"Brefeldin A, but not chloroquine, blocked STING trafficking, indicating that STING locates from the ER via the Golgi to vesicles in the perinuclear region (XREF_SUPPLEMENTARY)."

19776740

Betulinic acid affects JAK1

| 4

Betulinic acid inhibits JAK1. 4 / 4

| 4

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➶

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"Betulinic acid suppresses constitutive c-Src, JAK1 and JAK2 activation."

19937797

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➶

reach

"Pandey et al. [195] found that betulinic acid inhibited constitutive activation of STAT3, Src kinase, JAK1, and JAK2."

24388873

---

➶

reach

"We found that betulinic acid inhibited constitutive activation of STAT3, Src kinase, JAK1 and JAK2."

19937797

---

➶

reach

"Betulinic acid inhibited the constitutive activation of STAT3, Src kinase, JAK1, and JAK2."

22069560

Benzyl isothiocyanate affects RELA

| 4

Benzyl isothiocyanate inhibits RELA. 4 / 4

| 4

---

➶

reach

"BITC treatment led to decrease in NF-jB transcriptional activity and jB-DNA binding of p65 in BITC-treated pancreatic cancer cell lines, B9PC-3 and Capan-2 cells, while decreasing NF-jB/p65 phosphorylation at Ser536."

21786215

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➶

reach

"BITC treatment led to decrease in NF-kappaB transcriptional activity and kappaB-DNA binding of p65 in BITC treated pancreatic cancer cell lines, BxPC-3 and Capan-2 cells, while decreasing NF-kappaB and p65 phosphorylation at Ser536."

21786215

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➶

reach

"Inactivation of NF-kappaB and p65 by BITC in pancreatic cancer cells."

20484017

---

➶

reach

"BITC treatment led to decrease in NF-κB transcriptional activity and κB-DNA binding of p65 in BITC-treated pancreatic cancer cell lines, B×PC-3 and Capan-2 cells, while decreasing NF-κB/p65 phosphorylation at Ser536."

21786215

Auranofin affects NLRP3

| 4

Auranofin inhibits NLRP3. 4 / 4

| 4

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➶

reach

"These results show that auranofin inhibits the NLRP3 inflammasome, the activation of which is associated with acne symptoms."

32319265

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➶

reach

"In addition, auranofin suppressed the induction of the macrophage inflammasome receptor NLRP3, thereby attenuating inflammasome mediated generation of bioactive IL-1beta as well as induction of cell death."

25065288

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➶

reach

"In this study, we investigated whether auranofin, an anti-rheumatoid arthritis agent, inhibited NLRP3 inflammasome activation, thereby effectively treating acne vulgaris."

32319265

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➶

reach

"Auranofin suppressed NLRP3 inflammasome activation induced by Propionibacterium acnes, reducing the production of IL-1beta in primary mouse macrophages and human sebocytes."

32319265

Arsenite(3-) affects IKBKB

1 | 3

Arsenite(3-) inhibits IKBKB. 4 / 4

1 | 3

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➶

reach

"Thiol-reactive arsenite suppresses IKK activation through oxidative modification of a critical cysteine residue, Cys179, in the activation loop of IKKbeta [30]."

12023051

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➶

reach

"In the following study to explore the possible upstream protein kinase (such as ATR, CHK1, LKB1, DAPK1) that might be responsible for triggering p53 dependent IKKbeta repression induced by arsenite, we found the significant upregulation of DAPK1 expression and activation of ATR, CHK1 and LKB1 (data not shown) in HepG2 cells after arsenite exposure."

30177839

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➶

ctd

No evidence text available

10967126

---

➶

reach

"Immunocytochemical staining and Western blotting results revealed increased expression of Caveolin-1, IKKbeta, and COX-2 but decreased eNOS in SV-HUC-1 cells treated with low concentration of arsenite."

22824620

Arsenite(3-) affects FOS

| 4

Arsenite(3-) inhibits FOS. 4 / 4

| 4

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➶

reach

"In the current study, we show that arsenite down-regulates Akt and c-Fos by ubiquitination, decreases AP-1 activity and causes cell cycle dysregulation and apoptotic cell death."

20336670

---

➶

reach

"Co-exposure of the cells with both arsenite and MG-132 restored the arsenite induced c-Fos degradation (XREF_FIG)."

20336670

---

➶

reach

"The possibility that arsenite treatment prevented the participation of Fra1 or c-Fos in large complexes was examined."

20006635

---

➶

reach

"In summary, our present study reveals that under conditions of reduced GSH availability, arsenite down-regulated Akt and c-Fos via the ubiquitin-prteasome-mediated degradation."

20336670

Acetic acid affects MYD88

| 4

Acetic acid inhibits MYD88. 4 / 4

| 4

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➶

reach

"In 2010, Villa et al. reported a natural product named malyngamide F acetate, extracted from marine cyanobacterium Lyngbya majuscule, that selectively inhibits MyD88 dependent pathways involving TLR4 and TLR9 [XREF_BIBR]."

26899347

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➶

reach

"Furthermore, engagement of TLR3 (Poly I : C treatment) with and without malyngamide F acetate treatment did not change the transcription of TNF-alpha and IL-10 indicating that malyngamide F acetate selectively inhibits the MyD88 dependent pathway."

20006962

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➶

reach

"If malyngamide F acetate is indeed inhibiting the MyD88 dependent pathway then activation of TLR9, which is exclusively activated by CpG and depends solely on the MyD88 dependent pathway, would deliver a biological response with lower levels of TNF-alpha and IL-10 transcripts."

20006962

---

➶

reach

"Additional experiments utilizing CpG and Poly I : C stimulation to selectively activate the MyD88 dependent and -independent pathways via TLR9 and TLR3 substantiated the finding that malyngamide F acetate selectively inhibits the MyD88 dependent pathway."

20006962

VK-19911 affects MAPK14

4 |

VK-19911 inhibits MAPK14. 4 / 4

4 |

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➶

tas

No evidence text available

11354358

---

➶

tas

No evidence text available

17948975

---

➶

tas

No evidence text available

14667219

---

➶

tas

No evidence text available

24900264

U0126 affects STAT1

| 4

U0126 inhibits STAT1. 4 / 4

| 4

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➶

reach

"As shown in Figure XREF_FIG, both DPI and U0126 reduced the nuclear accumulation of JunB, c-Jun, and HIF-1alpha, but not Stat1 (which is DUOX2 independent) or Sp1 (which is constitutively expressed)."

27637085

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➶

reach

"MEK inhibitor U0126 inhibits viral gene expression [XREF_BIBR] as well as the activation of host c-Fos, c-Jun, c-Myc, and STAT1 molecules."

27854239

---

➶

reach

"As shown in XREF_FIG, levels of FOS, MSK1, STAT1 and STAT3 were significantly reduced in decidualized hESCs treated with U0126."

24086495

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➶

reach

"Compared with the untreated controls, Dip G markedly promoted the nuclear translocation of p-STAT1 (Ser727), which was blocked by U0126 (XREF_FIG)."

28471454

U0126 affects IFNB1

| 4

U0126 inhibits IFNB1. 4 / 4

| 4

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➶

reach

"Indeed, U0126 pretreatment significantly inhibited induction of both IFN-beta (XREF_FIG) and IL-6 (XREF_FIG) in response to poly I : C."

23892079

---

➶

reach

"PDTC inhibited the production of IL-8 and TNF-alpha whereas U0126 inhibited the synthesis of IFN-beta."

20125114

---

➶

reach

"Interestingly others also experienced a limited IFNbeta expression in mouse primary alveolar epithelial cells (AECs) treated with the MEK inhibitor U0126 (Pinto et al., 2011)."

29990517

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➶

reach

"PDTC inhibited the production of IL-8 and TNF-alpha, while U0126 inhibited the synthesis of IFN-beta."

21155840

Triflusal affects NFKB1

4 |

Triflusal inhibits NFKB1. 4 / 4

4 |

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drugbank

No evidence text available

19465361

---

➶

drugbank

No evidence text available

18317243

---

➶

drugbank

No evidence text available

15678110

---

➶

drugbank

No evidence text available

17194886

Sunitinib affects TYK2

4 |

Sunitinib inhibits TYK2. 4 / 4

4 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

22037378

Sunitinib affects IKBKE

4 |

Sunitinib inhibits IKBKE. 4 / 4

4 |

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

Shikonin affects CASP1

| 4

Shikonin inhibits CASP1. 4 / 4

| 4

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➶

reach

"In LPS primed BMDMs, PMA differentiated THP1, and PMs, shikonin significantly inhibited caspase-1 activation triggered by stimulation with ATP or poly (dA : dT), but not MDP or flagellin (XREF_FIG and XREF_SUPPLEMENTARY)."

27779186

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➶

reach

"In the in vitro assay using isolated caspase-1, we showed that shikonin directly inhibits caspase-1 in the same concentration range as the conventional caspase inhibitor Z-VAD-FMK (XREF_FIG)."

27467658

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➶

reach

"Collectively, our data demonstrated that shikonin concentration-dependently inhibits inflammasome activation by acting directly on caspase-1, however further studies are needed to elucidate the exact mechanism of shikonin inhibition of caspase-1 activity."

27467658

---

➶

reach

"Further, we observed that shikonin concentration-dependently inhibited the secretion and processing of pro-caspase-1 from primed and nigericin treated macrophages (XREF_FIG)."

27467658

SUNITINIB MALATE affects TYK2

4 |

SUNITINIB MALATE inhibits TYK2. 4 / 4

4 |

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tas

No evidence text available

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

SUNITINIB MALATE affects IKBKE

4 |

SUNITINIB MALATE inhibits IKBKE. 4 / 4

4 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

SB 203580 affects RELA

| 4

SB 203580 inhibits RELA. 4 / 4

| 4

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➶

reach

"Microinjection of p38 inhibitor SB203580 into the NAc prior to the application of morphine prevented the acquisition of CPP and inhibited the activation of p38, IkappaB-alpha and NF-kappaB p65."

21130118

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➶

reach

"LBPK95A, SB203580, and SC-514 ameliorated LPS induced rat lung injury and suppressed LPS induced downregulation of fractalkine by decreasing phospho-p38 MAPK and p65 NF- kappa B."

28634422

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➶

reach

"Twenty micromolar SP600125 and 10 muM SB203580 reduced the lipopolysaccharide caused increase in the NF-kappaB p65 to DNA binding activity in HaCaT cells."

29291542

---

➶

reach

"The LPS induced phosphorylation of MAPKs (p38, JNK and ERK1/2) and NF-kappaB p65 was also strongly inhibited by their inhibitors SB203580, U0126, SP600125 and PDTC, respectively."

29391237

SB 203580 affects FOS

| 4

SB 203580 inhibits FOS. 4 / 4

| 4

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➶

reach

"C-Fos and c-Jun mRNAs were induced by TNF-alpha, and PD98059 (MEK inhibitor) and SB203580 (p38 inhibitor) abolished the up-regulation of c-Fos."

17424890

---

➶

reach

"In this study, MEK (PD98059) and p38 MAPK (SB203580) inhibitors suppressed the IL-1beta-induced activation of c-Fos."

27393034

---

➶

reach

"Investigation of the effects of specific kinase inhibitors revealed that SB203580, a specific inhibitor for p38 MAPK, significantly blocked the upregulation of c-fos and the subsequent neuronal cell death."

29913201

---

➶

reach

"Moreover, the present study showed that IL-17A induced the nuclear translocation of c-Jun and c-Fos, which could be effectively inhibited by the JNK inhibitor SP600125 or the p38 inhibitor SB203580."

26988982

RvD1 affects MAP3K7

| 4

RvD1 inhibits MAP3K7. 4 / 4

| 4

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➶

reach

"Given that the specific inhibition of TAK1 blocks pro inflammatory signaling and that RvD1 attenuates TAK1 activation, we hypothesized that RvD1 inhibits TAK1 activation by interfering with the formation of poly (I : C)-mediated signaling components."

25320283

---

➶

reach

"We further illustrate that RvD1 inhibits TAK1 activation, at least partly, via perturbing the association of a poly (I : C) and mediated complex involving TAK1, TAB1 and TRAF6."

25320283

---

➶

reach

"It is worthwhile to note that docosahexaenoic acid (DHA), a precursor of RvD1, was shown to inhibit TAK1 activation via a GPR120 dependent signaling pathway."

25320283

---

➶

reach

"Given that the RvD1 inhibits TAK1 activation and activates-arrestin, it is very likely that RvD1 also interferes with the complex formation via a similar mechanism."

25320283

RES affects NLRP3

| 4

RES inhibits NLRP3. 4 / 4

| 4

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➶

reach

"Moreover, RES treatment attenuated NLRP3 inflammasome protein activation at 48 hours after ischemia in DM rats while concomitantly reducing the expression of caspase-1 and release of IL-1beta and IL-18."

27867451

---

➶

reach

"RES, by activation of sirtuin-1 (Sirt-1) signaling, can inhibit nuclear factor kappa beta (NF-kappab) and then NLRP3 inflammasome activity."

29456821

---

➶

reach

"In this study, we showed that RES by its anti-inflammatory properties decreases NLRP3 inflammasome activity in the testis tissue."

29456821

---

➶

reach

"Besides, RES alleviated PM 2.5 -induced cytotoxicity, inhibited autophagic process and NLRP3 inflammasome activity and decreased IL-1beta production in BEAS-2B cells."

31295660

PCID:76516568 affects MAPK8

| 4

PCID:76516568 inhibits MAPK8. 4 / 4

| 4

---

➶

sparser

"JNK-IN-8 potently inhibits JNK1, 2 and 3 enzymatic activity with IC 50 s of 4.7 nM, 18.7 nM and 1.0 nM respectively and inhibits a c-Jun, a direct phosphorylation substrate of JNK, with an EC 50 of 486 nM in Hela cell."

23438744

---

➶

sparser

"We determined that inhibition of JNK1 and JNK2 by JNK-IN-8 was approximately equivalent in regards to decreased phosphorylation of c-Jun at the JNK specific, serine 63 site."

29285221

---

➶

sparser

"The result that JNK1 inhibition by JNK-IN-8 is important for synergy with lapatinib is not surprising considering that JNK-IN-8 was shown to have greater activity toward purified, recombinant JNK1 in vitro [ xref ]."

29285221

---

➶

sparser

"This indicates that the inhibition of endogenous JNK1 by JNK-IN-8 is not greater than inhibition of JNK2."

29285221

NAC affects IKBKB

| 4

NAC inhibits IKBKB. 4 / 4

| 4

---

➶

reach

"In this respect, however, it should be noted that NAC failed to inhibit IKKalpha and IKKbeta activity in vitro (data not shown), indicating that NAC mediates the suppression of these kinases through an unknown cellular redox sensitive mechanism (s)."

10788610

---

➶

reach

"The induction of reporter genes by TRADD, TRAF2, NIK, IKKalpha, or IKKbeta decreased partially when the cells were treated with NAC for 6 h in a dose dependent manner."

10788610

---

➶

reach

"Regarding the mechanism underlying NAC mediated suppression of IKKalpha and IKKbeta, a possible explanation is that NAC directly inhibits the kinase activity of IKKalpha and IKKbeta."

10788610

---

➶

reach

"Furthermore, NAC suppressed the activation of IKKalpha and IKKbeta triggered by the overexpression of NIK."

10788610

NAC affects FOS

| 1 3

NAC inhibits FOS. 4 / 4

| 1 3

---

➶

sparser

"As shown in xref , both 15(S)-HETE and 15(S)-HPETE upregulated the mRNA levels of c-FOS and c-JUN, which was inhibited by NAC."

24732589

---

➶

reach

"We next ascertained that the ROS scavenger NAC, the EGFR inhibitor AG, the MEK inhibitor PD and the ROCK inhibitor Y prevent c-fos induction by LA (XREF_FIG)."

28924490

---

➶

reach

"NAC in combination with vanadate appeared to increase the efficacy of c-fos and c-jun inhibition, while decreasing toxicity."

17696279

---

➶

reach

"Therefore, these data indicate that BA and the antioxidant NAC effectively inhibited H 2 O 2 -induced activation of PKC, ERK and c-Fos."

26542288

NAC affects CHUK

| 4

NAC inhibits CHUK. 4 / 4

| 4

---

➶

reach

"The induction of reporter genes by TRADD, TRAF2, NIK, IKKalpha, or IKKbeta decreased partially when the cells were treated with NAC for 6 h in a dose dependent manner."

10788610

---

➶

reach

"Furthermore, NAC suppressed the activation of IKKalpha and IKKbeta triggered by the overexpression of NIK."

10788610

---

➶

reach

"In this respect, however, it should be noted that NAC failed to inhibit IKKalpha and IKKbeta activity in vitro (data not shown), indicating that NAC mediates the suppression of these kinases through an unknown cellular redox sensitive mechanism (s)."

10788610

---

➶

reach

"Regarding the mechanism underlying NAC mediated suppression of IKKalpha and IKKbeta, a possible explanation is that NAC directly inhibits the kinase activity of IKKalpha and IKKbeta."

10788610

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects MAVS

| 1 3

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits MAVS. 4 / 4

| 1 3

---

➶

reach

"To address whether proteasomal or lysosomal degradation is involved in US9 mediated MAVS reduction, HEK293T cells were treated with either MG132, a proteasome inhibitor, or chloroquine, a lysosome inhibitor."

29317664

---

➶

medscan

"Importantly, treatment with the proteasome inhibitor MG132 prevented degradation of the larger MAVS isoform (Figure ), signifying that following RIG-I-like receptor activation, the larger MAVS isoform is ubiquitinated then selectively degraded by the proteasome."

22626058

---

➶

reach

"Addition of the proteasome inhibitor MG132 potently inhibited the cleavage of MAVS relative to cells treated with apoptosis-inducers alone (XREF_FIG)."

18692023

---

➶

reach

"Finally, in agreement with confocal data, addition of MG132 to STS incubated cells reverses the change in MAVS localization, the majority being found in the membrane fraction as expected (XREF_FIG)."

18692023

N-acetyl-L-cysteine affects MAPK14

| 4

N-acetyl-L-cysteine inhibits MAPK14. 4 / 4

| 4

---

➶

medscan

"This mechanism is supported by the ability of N-acetyl cysteine to prevent dissociation of Trx-ASK1 and activation of the p38 MAPK pathway."

16449798

---

➶

medscan

"N-acetylcysteine treatment prevented the activation of p38 MAP kinase and rescued the survivin protein levels."

24128853

---

➶

medscan

"N-acetyl-l-cysteine (NAC) inhibited the activation of JNK and p38-MAPK."

24402682

---

➶

medscan

"In addition, N-acetylcysteine prevented lipopolysaccharide-induced activation of p38 MAPK and JNK but not phosphorylation and subsequent degradation of IkB."

18038907

N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide affects IKBKB

2 | 2

N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide inhibits IKBKB. 4 / 4

2 | 2

---

➶

reach

"Hormone dependent (LNCaP) and hormone independent (PC-3 and DU-145) prostate cancer cell lines were exposed to docetaxel alone or combined with the NF-kappaB inhibitor PS-1145 (an inhibitor of IkappaB kinase-2)."

17000695

---

➶

reach

"Because p53 may function by partial inhibition of NF-kappaB activity, we combined Nutlin-3a with PS-1145, a small molecule that specifically inhibits IKKbeta."

24412360

---

➶

tas

No evidence text available

17850214

---

➶

tas

No evidence text available

20044255

Minocycline affects CASP1

4 |

Minocycline inhibits CASP1. 4 / 4

4 |

---

➶

drugbank

No evidence text available

18977395

---

➶

drugbank

No evidence text available

11383749

---

➶

drugbank

No evidence text available

17192486

---

➶

drugbank

No evidence text available

10888929

Met-Asp affects FOS

| 4

Met-Asp inhibits FOS. 4 / 4

| 4

---

➶

reach

"MD decreased visually induced c-Fos activation in GAD67 and CR positive neurons."

19194492

---

➶

reach

"As expected, MD decreased visual induction of c-Fos through the deprived eye (XREF_FIG)."

19194492

---

➶

reach

"In summary, MD decreases visually induced c-Fos activation in GAD67 and CR positive neurons."

19194492

---

➶

reach

"If MD reduces c-Fos activation in this subpopulation similarly to the overall reduction observed in the cortical population, then the D/F ratio should not change."

19194492

LY294002 affects NFKBIA

| 1 3

LY294002 inhibits NFKBIA. 4 / 4

| 1 3

---

➶

reach

"Akt has been shown to phosphorylate IkappaBalpha and induce its degradation, however LY294002 treatment only further enhanced the degradation of IkappaBalpha induced by LMP1 (XREF_FIG)."

18757414

---

➶

medscan

"The OPN-mediated increases in IKK alpha/beta, IkappaBalpha and p65 Ser(536) phosphorylation were inhibited by Ly294002, Akt inhibitor and PD98059. 32999999="S536"}"

18996613

---

➶

reach

"Although the oleate activated AKT, IkappaBalpha and ERK were inhibited by LY294002, parthenolide and U0126, respectively, only LY294002 and parthenolide significantly inhibited the oleate induced PTX3 expression."

28489600

---

➶

reach

"Additionally, LY294002, AKT-shRNA and IkappaBalpha-shRNA could decrease the protein content of phospho-IkappaBalpha and phospho-IKKbeta in STC1 overexpressed HeLa and CaSki cells compared with the control cells."

28545028

L-prolylglycine affects MYD88

| 4

L-prolylglycine inhibits MYD88. 4 / 4

| 4

---

➶

reach

"Importantly, Pg (but not Pam3CSK4) induced degradation of MyD88 also in vivo, as shown by examining neutrophils harvested from Pg inoculated mouse chambers (XREF_FIG)."

24922578

---

➶

reach

"Strikingly, Pg caused time dependent reduction in the levels of MyD88 protein but not mRNA (XREF_FIG), suggesting that Pg causes MyD88 degradation at least in vitro."

24922578

---

➶

reach

"The ability of Pg to degrade MyD88 was completely reversed by C5aRA or anti-TLR2 (XREF_FIG), suggesting that degradation is mediated by C5aR-TLR2 crosstalk."

24922578

---

➶

reach

"Indeed, when Smurf1 protein expression was diminished by siRNA to Smurf1, the ability of Pg to degrade MyD88 was suppressed (XREF_FIG)."

24922578

Interferon alfacon-1 affects IFNAR1

4 |

Interferon alfacon-1 inhibits IFNAR1. 4 / 4

4 |

---

➶

drugbank

No evidence text available

17139284

---

➶

drugbank

No evidence text available

17016423

---

➶

drugbank

No evidence text available

11752352

---

➶

drugbank

No evidence text available

12528473

Interferon alfa-2b affects IFNAR2

4 |

Interferon alfa-2b inhibits IFNAR2. 4 / 4

4 |

---

➶

drugbank

No evidence text available

11752352

---

➶

drugbank

No evidence text available

17016423

---

➶

drugbank

No evidence text available

7584665

---

➶

drugbank

No evidence text available

17139284

Interferon alfa-2b affects IFNAR1

4 |

Interferon alfa-2b inhibits IFNAR1. 4 / 4

4 |

---

➶

drugbank

No evidence text available

10567921

---

➶

drugbank

No evidence text available

17016423

---

➶

drugbank

No evidence text available

11752352

---

➶

drugbank

No evidence text available

17139284

Human interferon beta affects IFNAR1

4 |

Human interferon beta inhibits IFNAR1. 4 / 4

4 |

---

➶

drugbank

No evidence text available

27572132

---

➶

drugbank

No evidence text available

17562848

---

➶

drugbank

No evidence text available

25356432

---

➶

drugbank

No evidence text available

23913971

His-Ser affects NLRP3

| 4

His-Ser inhibits NLRP3. 4 / 4

| 4

---

➶

reach

"This HS induced activation of the NLRP3 inflammasome was significantly blocked by MSC transplantation into the renal medulla in Dahl S rats."

26764201

---

➶

reach

"Moreover, HS also inhibited the formation of NLRP3 and ASC specks and maintained the interaction of HSP70 with NLRP3 under nigericin treatment."

30874540

---

➶

reach

"In this context, there arises an interesting question required to be addressed by future work, that is, whether HRS possesses the ability to inhibit the presumed HS induced activation of NLRP3 during the development of pancreatitis."

25214720

---

➶

reach

"Heat Shock (HS) inhibits NLRP3 inflammasome activation in vitro and in vivo."

30874540

Glu-Ala affects RELA

| 4

Glu-Ala inhibits RELA. 4 / 4

| 4

---

➶

reach

"EA at Zusanli could inhibit NF-kappaBp65 and proinflammatory cytokines production after intestinal I/R injury; its mechanism may be related to the cholinergic anti-inflammatory pathway."

29333186

---

➶

reach

"Furthermore, immunofluorescence staining also confirmed that 2Hz EA obviously suppressed the co-expression of microglia activation marker CD11b and TLR4 or MyD88, as well as the activation of NF-kappaB p65 in SNI rats."

31695479

---

➶

reach

"EA treatment significantly reduced the nuclear p65 content, accompanied by a decreased ratio of p65 protein content in the nucleus to that in the cytoplasm in the adipose tissue."

26714835

---

➶

reach

"This study just attempts to explore its possible mechanism from the perspective of cholinergic anti-inflammatory pathway, and the results showed that both EA and alpha7 nAChR agonists could relieve the intestine damage and decrease levels of mucosal NF-kappaBp65 and serum IL-6 and TNF-alpha."

29333186

Glu-Ala affects NLRP3

| 4

Glu-Ala inhibits NLRP3. 4 / 4

| 4

---

➶

reach

"In this study we investigated whether EA inhibits NLRP3 inflammasome activation through CB2 receptors and thus relieving inflammatory pain."

28782714

---

➶

reach

"The EA pretreatment suppressed NLRP3 inflammasome activation, reduced lung edema, and inhibited IL-1beta release into the serum and BALF after CPB."

30680695

---

➶

reach

"Furthermore, real-time RT-PCR analysis revealed that UA or EA pretreatment significantly suppressed the elevated mRNA levels of inflammation markers NLRP3, IL-1beta, and TNF-alpha in alcohol exposed AML12 cells (XREF_FIG C)."

30071471

---

➶

reach

"Immunofluorescence labeling showed that NLRP3 inflammasome elicited by CFA in the skin macrophages were decreased by EA."

28782714

Glu-Ala affects FOS

| 4

Glu-Ala inhibits FOS. 4 / 4

| 4

---

➶

reach

"We found that EA at GB20 reversed c-Fos immunoreactivity changes in migraine related brain areas (compared to the Model group)."

26438555

---

➶

reach

"EA at the limbic acupoints ST36 and PC6 increased the intragastric pressure and decreased the numbers of double labeled OT neurons and c-fos neurons within the PVN [XREF_BIBR]."

32684734

---

➶

reach

"Application of 2Hz EA to LI4 and LI11 decreased the number of c-Fos positive nuclei induced by GNTI."

23878596

---

➶

reach

"Administration of 2Hz EA to the LI4 and LI11 acupoints decreased the number of c-Fos positive nuclei induced by GNTI."

23878596

FILGOTINIB affects JAK1

4 |

FILGOTINIB inhibits JAK1. 4 / 4

4 |

---

➶

tas

No evidence text available

25369270

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

24417533

---

➶

tas

No evidence text available

26351728

FILGOTINIB HYDROCHLORIDE affects JAK1

4 |

FILGOTINIB HYDROCHLORIDE inhibits JAK1. 4 / 4

4 |

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

25369270

---

➶

tas

No evidence text available

24417533

---

➶

tas

No evidence text available

26351728

Acetylsalicylic acid affects CASP1

4 |

Acetylsalicylic acid inhibits CASP1. 4 / 4

4 |

---

➶

drugbank

No evidence text available

23110215

---

➶

drugbank

No evidence text available

24874482

---

➶

drugbank

No evidence text available

26980842

---

➶

drugbank

No evidence text available

30693272

ATP affects IKBKB

| 4

ATP inhibits IKBKB. 4 / 4

| 4

---

➶

reach

"Thus, earlier discovery efforts of pharmacological inhibitors of the NF-kappaB pathway were indeed aimed at developing ATP competitive inhibitors of IKK-2 activity [19,20]."

20176108

---

➶

reach

"Taken together, these data suggest that the mechanisms of action of NBD peptides are distinct from those of ATP kinase inhibitors of IKK-2."

20167598

---

➶

reach

"Pharmacological inhibition of NFkappaB p65 Serine (536) phosphorylation by SC-514, an ATP dependent competitive inhibitor of IKKbeta, significantly reduced p62 mRNA as well as protein levels in ARPE-19 cells under oxidative stress (XREF_FIG)."

28222108

---

➶

reach

"Evaluation of small molecule ATP binding site inhibitors of IKKbeta re-inforces this concept although off-target side effects together with the compensatory activity of IKKalpha homodimers observed in the presence of IKKbeta inhibition may reduce their therapeutic efficacy XREF_BIBR, XREF_BIBR."

24798348

AS-602868 affects IKBKB

4 |

AS-602868 inhibits IKBKB. 4 / 4

4 |

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➶

tas

No evidence text available

24813730

---

➶

tas

No evidence text available

20044255

---

➶

tas

No evidence text available

18501602

---

➶

tas

No evidence text available

19285872

AICA ribonucleotide affects STAT1

| 4

AICA ribonucleotide inhibits STAT1. 4 / 4

| 4

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➶

reach

"AICAR reduced IFN-gamma-induced STAT1 by 36.5% +/- 3.4% in the GFP cells, and by 18.5% +/- 5.7% (n = 3, p < 0.05) in cells with reduced AMPKalpha (XREF_FIG), indicating that the AICAR mediated reduction in STAT1 occurs in an AMPK dependent manner."

23180823

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➶

reach

"AICAR significantly attenuated total STAT1 nuclear accumulation (lane 7) and retained STAT1 in the cytosol (lane 3)."

23180823

---

➶

reach

"Importantly, AICAR suppressed IFN-gamma-induced STAT1 and other inflammatory molecules at the transcriptional level."

23180823

---

➶

reach

"This regulation occurs at the mRNA level as AICAR also significantly suppressed IFN-gamma-induced STAT1 mRNA in a concentration dependent fashion (XREF_FIG)."

23180823

7,9-dihydro-1H-purine-2,6,8(3H)-trione affects NLRP3

| 4

7,9-dihydro-1H-purine-2,6,8(3H)-trione inhibits NLRP3. 4 / 4

| 4

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➶

reach

"Oral administration of CAPE prevents uric acid crystals induced gout in mice by blocking NLRP3 inflammasome activation."

27934918

---

➶

reach

"Doliroside A attenuates monosodium urate crystals induced inflammation by targeting NLRP3 inflammasome."

25064339

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➶

reach

"The deleterious effects of urate are primarily attributed to its ability to trigger the formation of reactive oxygen species (ROS) and activate NLRP3."

27209322

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➶

reach

"CAPE suppresses uric acid crystal induced NLRP3 inflammasome activation in bone marrow derived primary macrophages."

27934918

6-(N-carbamoyl-2,6-difluoroanilino)-2-(2,4-difluorophenyl)-3-pyridinecarboxamide affects MAPK14

1 1 | 2

6-(N-carbamoyl-2,6-difluoroanilino)-2-(2,4-difluorophenyl)-3-pyridinecarboxamide inhibits MAPK14. 4 / 4

1 1 | 2

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sparser

"xref , xref shows that VX-702 inhibited the target kinase p38α and its closely related kinase p38β with high potency, but none of the other p38 kinases or CMGC kinases were inhibited."

28095176

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➶

signor

No evidence text available

Other

---

➶

tas

No evidence text available

19950901

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➶

sparser

"As predicted, tofacitinib, kenpaullone, and VX-702 strongly inhibited their respective targets, JAK3, GSK3β, and p38α, respectively. xref xref – xref The pan–kinase inhibitor staurosporine inhibited almost all of the kinases in the panel while imatinib showed no kinase inhibition."

28095176

5Z-7-Oxozeaenol affects MAP3K7

| 4

5Z-7-Oxozeaenol inhibits MAP3K7. 4 / 4

| 4

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reach

"To better understand the molecular basis of this interaction, pharmacologic inhibitors SB43152 and 5Z-7-Oxozeaenol were used to inhibit the kinases of TbetaRI and TAK1, respectively."

29703898

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➶

reach

"Huang et al. confirmed that the converse is also true -- TAK1 inhibition by 5Z-7-Oxozeaenol (5Z-O) was associated with suppression of downstream signaling and CCR7 downregulation in breast cancer cell lines, resulting in decreased tumor growth and lymphatic invasion when tested in vivo in mouse axillary lymph nodes [XREF_BIBR]."

28858212

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➶

reach

"TGFbeta activated Kinase 1 (TAK1) Inhibition by 5Z-7-Oxozeaenol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage."

26100626

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➶

reach

"For TAK1 inhibition, BMDMs were treated with 0.1 muM 5Z-7-Oxozeaenol (TAK1i) for 1 h followed by LPS (100 ng/mL) post-treatment for the indicated times."

32547960

5-(2-methylpiperazine-1-sulfonyl)isoquinoline affects JUN

| 4

5-(2-methylpiperazine-1-sulfonyl)isoquinoline inhibits JUN. 4 / 4

| 4

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➶

reach

"The same concentration-range of H-7 completely inhibited the induction of c-jun by human IL-3."

1737930

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➶

reach

"Conversely, H7 (50 muM), a broad-base serine/threonine kinase inhibitor was shown to antagonize the activation of c-Jun and JNK pathway by adrenomedullin.To verify the functional activation of c-Jun by adrenomedullin, nuclear proteins extracted from U87 cells were subjected to electrophoretic mobility shift assays to examine DNA binding activity at the AP-1 site."

19166930

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reach

"H7 (50 microM), genistein (2 microM) and okadaic acid (20 nM), all block the induction of c-jun and c-fos mRNA accumulation in the H2O2 treated rat lenses."

7835407

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➶

reach

"As shown in Fig. 3, H-89 did not affect C2-ceramide-induced c-jun expression, whereas H-7 and staurosporine strongly inhibit c-jun induction by C2-ceramide."

12135749

5-(2-methylpiperazine-1-sulfonyl)isoquinoline affects FOS

| 1 3

5-(2-methylpiperazine-1-sulfonyl)isoquinoline inhibits FOS. 4 / 4

| 1 3

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➶

reach

"H-7 (50 microM) and genistein (100 microM) blocked c-fos induction as did PKC down-regulation with chronic treatment of phorbol 12-myristate 13-acetate."

7968349

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➶

reach

"Similarly, the protein kinase C inhibitor 1-(5-isoquinoline-sulphonyl)-2-methylpiperazine dihydrochloride (H7) and down-regulation of protein kinase C by prolonged exposure to phorbol-12-myristate 13-acetate blocked c-fos induction."

8845939

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➶

reach

"Furthermore, studies carried out using H7, a protein kinase A/protein kinase C inhibitor, blocked c-fos induction, whereas no effect was observed with bisindolylmaleimide, a specific protein kinase C inhibitor."

9187264

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➶

sparser

"All three inducers elicit a characteristic immediate early response of c-fos which is inhibited by the protein kinase inhibitor H7 but enhanced by the protein synthesis inhibitor cycloheximide."

1617671

3-(trimethylsilyl)propane-1-sulfonic acid affects STAT1

| 4

3-(trimethylsilyl)propane-1-sulfonic acid inhibits STAT1. 4 / 4

| 4

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➶

reach

"DSS induced colitis was attenuated in male STAT1 incrementIEC mice."

29419930

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➶

reach

"Our findings suggest that SOCS-1, particularly in T cells, prevents the development of DSS induced colitis in mice by inhibiting IFN-gamma and STAT1 signaling and by subsequently regulating Treg cell development."

18381351

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➶

reach

"However, AOM and DSS induced STAT1 activation was dramatically reduced in colons of Casp1 -/- mice during early stages of tumorigenesis (day 15 post-AOM) (XREF_FIG)."

20855874

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➶

reach

"DSS induced colitis was reduced in STAT1 knockout mice (Bandyopadhyay etal., 2008; Berry etal., 2012) whereas mice with haploinsufficiency of SOCS1, a negative regulator of STAT1, showed more severe colitis (Horino etal., 2008)."

29419930

24,25-Dihydroxyvitamin D affects NLRP3

| 4

24,25-Dihydroxyvitamin D inhibits NLRP3. 4 / 4

| 4

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➶

reach

"Indeed, vitamin C, vitamin D, and omega-3 fatty acids have all been shown to inhibit the NLRP3 inflammasome and may work synergistically against the cytokine storm associated with COVID-19 and specifically against the neuro inflammation associated with its delirium."

| PMC

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➶

reach

"* Vitamin D : In certain conditions, vitamin D has been found to decrease NLRP3 inflamasome activation XREF_BIBR and vitamin D receptor activation reduces IL-1b secretion."

32229082

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➶

reach

"In an animal study, we found that NLRP3 activation was significantly correlated with damage to retinal cells and vascular permeability, whereas vitamin D 3 downregulated NLRP3, which subsequently reduced the rate of apoptosis and reduced vascular permeability in the retinas of diabetic rats."

29682582

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➶

reach

"In addition, vitamin D negatively regulates the NLRP3 inflammasome via VDR signaling to effectively inhibit IL-1beta secretion."

31866999

24,25-Dihydroxyvitamin D affects NFKBIA

| 4

24,25-Dihydroxyvitamin D inhibits NFKBIA. 4 / 4

| 4

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reach

"In the present study, we show that 1,25 (OH) 2 D 3 increased IkappaBalpha protein expression in preadipocytes and this suggests that vitamin D 3 may inhibit the activation of NF-kappaB signalling, probably by increasing the stability of IkappaBalpha protein."

22508334

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➶

reach

"Vitamin D induces the NF-kappaB inhibitory protein IkappaBalpha in airway epithelium."

20008294

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➶

reach

"In addition, vitamin D treatment significantly (P <.05) decreased monocyte induced p-IkappaBalpha in cytosol and NFkappaB-p65 in the nucleus and increased IkappaBalpha in cytosol in UtSM cells."

24262718

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➶

reach

"In addition, vitamin D treatment significantly (p < 0.05) decreased monocyte induced p-IkappaBalpha in cytosol, NFkappaB-p65 in the nucleus and increased IkappaBalpha in cytosol in UtSM cells."

24262718

24,25-Dihydroxyvitamin D affects IFNB1

| 4

24,25-Dihydroxyvitamin D inhibits IFNB1. 4 / 4

| 4

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reach

"Vitamin D and its metabolites could inhibit T-cell proliferation and suppress production of interleukin 1, interleukin 2, tumor necrosis factor alpha and interferon-beta [16,17,25,26]."

12482639

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➶

reach

"Thus, vitamin D inhibits RSV induction of NF-kappaB-driven IFN-beta and CXCL10 secretion, as also demonstrated in this study."

26035247

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➶

reach

"Vitamin D augmentation of IFN responses was seen in untreated and in IFN-beta-1b-treated MS. The combination of vitamin D plus IFN-beta reduced Th1 and Th17 cytokines, and increased Th2 responses, reversing the effect of IFN-beta alone."

31582399

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➶

reach

"If vitamin D suppresses IFNbeta induction and, subsequently, interferon driven genes which have diverse antiviral activities, then how is the antiviral state maintained?"

20008294

2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]-3-azetidinyl]acetonitrile affects TYK2

4 |

2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]-3-azetidinyl]acetonitrile inhibits TYK2. 4 / 4

4 |

---

➶

tas

No evidence text available

24417533

---

➶

tas

No evidence text available

26351728

---

➶

tas

No evidence text available

29298069

---

➶

tas

No evidence text available

26701356

2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile affects TRIM25

| 4

2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile inhibits TRIM25. 4 / 4

| 4

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➶

reach

"Verapamil reduced frequency of occurrence and amplitude of EFP until EFP failed."

1521145

---

➶

reach

"In the hippocampus verapamil suppressed PDS and EFP within 70 +/- 16 min (40 mumol/l) and within 39 +/- 5 min (60 mumol/l)."

7834332

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➶

reach

"Both verapamil and nifedipine suppressed EFP after a transient increase in repetition rate."

12480168

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➶

reach

"Upon application of non NMDA glutamate subreceptor blocker the EFP were abolished in all trials, while application of the organic calcium channel blocker verapamil only suppressed the EFP in some cases."

11454323

2-(2-amino-3-methoxyphenyl)chromen-4-one affects MAPK8

| 2 1 1

2-(2-amino-3-methoxyphenyl)chromen-4-one inhibits MAPK8. 4 / 4

| 2 1 1

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➶

reach

"Furthermore, PD 98059 treatment almost completely abolished JNK1 activation."

11527387

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➶

sparser

"To this end, osteoblast cells were infected in the presence of DHEA and the specific inhibitors of MAPK signaling pathways, PD98059, SB203580, and SP600125, which inhibit ERK1/2, p38, and JNK1/2, respectively."

29434601

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➶

medscan

"However, inhibition of the classic mitogen-activated protein kinase pathway using the PD98059 and U0126 inhibitors and inhibition of SAPK/JNK pathway did not suppress C pneumoniae-induced ICAM-1 expression."

12714566

---

➶

medscan

"SP600125 and PD98059 were used to block the activation of c-Jun terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) respectively."

21131736

2-(2-amino-3-methoxyphenyl)chromen-4-one affects JUN

| 1 3

2-(2-amino-3-methoxyphenyl)chromen-4-one inhibits JUN. 4 / 4

| 1 3

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➶

sparser

"Surprisingly, only PD98059 inhibited the ALV-induced c-Jun phosphorylation while SP600125 or SB203580 had no influence on c-Jun activation at 15 min p.i (Fig. 6a-c) ."

26754177

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➶

sparser

"More importantly, PD98059 simultaneously inhibited the ALV-induced c-Jun phosphorylation and VEGF-A expression at 120 h p.i (Fig. 6d) ."

26754177

---

➶

medscan

"Treating vascular smooth muscle cells with PD98059, the ERK inhibitor, inhibited ERK activation and KLF5 phosphorylation as well as the interaction between KLF5 and c-Jun."

19628677

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➶

sparser

"Surprisingly, PD98059 simultaneously inhibited the ALV-induced c-Jun phosphorylation and VEGF-A expression at 120 h p.i."

26754177

15-deoxy-Delta(12,14)-prostaglandin J2 affects CASP1

| 4

15-deoxy-Delta(12,14)-prostaglandin J2 inhibits CASP1. 4 / 4

| 4

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➶

reach

"15d-PGJ2 inhibited caspase-1 autoproteolysis (monitored by generation of the p10 fragment) as well as maturation and secretion of IL-1beta in LT treated cells at a step subsequent to NF-kappaB signaling (XREF_FIG)."

25681332

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➶

reach

"We report that the eicosanoid 15-deoxy-Delta 12,14 -prostaglandin J2 (15d-PGJ2) and related cyclopentenone prostaglandins inhibit caspase-1 activation by the NLRP1 and NLRP3 inflammasomes."

25681332

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➶

reach

"Instead, 15d-PGJ2 prevents the autoproteolytic activation of caspase-1 and the maturation of IL-1beta through induction of a cellular state inhibitory to caspase-1 proteolytic function."

25681332

---

➶

reach

"Given the ability of this compound to inhibit multiple inflammasomes, we hypothesized that 15d-PGJ2 could inhibit caspase-1 directly."

25681332

(-)-epigallocatechin 3-gallate affects IKBKB

| 4

(-)-epigallocatechin 3-gallate inhibits IKBKB. 4 / 4

| 4

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➶

reach

"EGCG was shown to inhibit the activity of IKKbeta which is the key kinase in the canonical pathway for NF-kappaB activation in MyD88 dependent pathway of TLRs."

16890209

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➶

reach

"We have also shown that EGCG inhibits IKK-alpha and IKK-beta activity in SAOS-2 cells with concominant down regulation of NF-kappaB and induction of apoptosis."

20462508

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➶

reach

"We observed that EGCG decreased the triglyceride (TG) concentration in rat livers and suppressed TLR4, TRAF6, IKKbeta, p-IKKbeta, p-NF-kappaB, and TNF-alpha levels compared with those in the HFD group, whereas PI3K, AKT, IRS-1, and IRS-2 indicators were improved."

32281563

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➶

reach

"The group found that flavonoid EGCG (Epigallocatechin-3-gallate) inhibits IKKbeta, a downstream signaling component of the MyD88 dependent pathway, in addition to inhibiting NF-kappaB activation induced by TLR4 and TLR2 agonists [XREF_BIBR]."

26899347

(-)-epigallocatechin 3-gallate affects FOS

1 | 3

(-)-epigallocatechin 3-gallate inhibits FOS. 4 / 4

1 | 3

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➶

reach

"Therefore, EGCG inhibits c-Fos, a component of AP-1, to inhibit cell proliferation and cell survival."

28063168

---

➶

ctd

No evidence text available

12663506

---

➶

reach

"Interestingly, in another study where EGCG blocked the UVB induced c-Fos activation in a human keratinocyte cell line HaCaT, inhibition of p38 activation was suggested as the major mechanism underlying the effects of EGCG [XREF_BIBR]."

21827739

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➶

reach

"Reporter assays indicated that both EGCG and Poly E inhibited the transcriptional activity of the activator protein 1 (AP-1), c-fos, nuclear factor kappaB, and cyclin D1 promoters."

15814656

(-)-epigallocatechin 3-gallate affects CASP1

| 4

(-)-epigallocatechin 3-gallate inhibits CASP1. 4 / 4

| 4

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➶

reach

"Furthermore, EGCG inhibited the activation of caspase-1 in HMC-1 cells."

21833768

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➶

reach

"177 In one study, EGCG resulted in NFkappaB inhibition, which was associated with reduced melanoma cell interleukin-1beta (IL-1beta) secretion, downregulation of the inflammasome component, nuclear localization leucine-rich-repeat protein 1 (NLRP1), and decreased caspase-1 activation."

25597784

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➶

reach

"In this study, we found that NO treatment resulted in caspase-1 activation and IL-1beta production, while EGCG inhibited the observed NO induced increase in IL-1beta production and caspase-1 activation, suggesting that the caspase-1 pathway is a potential therapeutic target for preventing NO induced ototoxic damage."

23028481

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➶

reach

"Since inflammasomes are involved in IL-1beta secretion, we investigated whether IL-1beta suppression was mediated by inflammasomes, and found that EGCG treatment led to downregulation of the inflammasome component, NLRP1, and reduced caspase-1 activation."

21982776

(+)-artemisinin affects RELA

| 4

(+)-artemisinin inhibits RELA. 4 / 4

| 4

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➶

reach

"Subcelluar fractionation revealed that the exogenous p65 NF-kappaB subunit that is produced from the p65-CMV expression vector accumulated in the nucleus of artemisinin treated and untreated cells to approximately the same extent (XREF_FIG) and therefore overrides the artemisinin disruption of endogenous p65 nuclear accumulation."

24296733

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➶

reach

"To determine if one or more of these sites plays a role in conferring artemisinin responsiveness to the CDK4 promoter, chromatin immunoprecipitation was used to directly determine whether artemisinin disrupts the endogenous interactions of Sp1, AP-1, p50, and p65 with the CDK4 promoter."

24296733

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➶

reach

"Our results provide direct evidence that artemisinin disrupts interactions of the p50 and p65 subunits of NF-kB with a critical cell cycle target gene promoter to mediate an anti-proliferative response in human endometrial cancer cells."

24296733

---

➶

reach

"Therefore, given the observed effects of artemisinin disrupting the binding of NF-kappaB subunits p65 and p50 to the CDK4 promoter, we investigated whether artemisinin disrupts NF-kappaB localization into the cell nuclei."

24296733

(+)-abscisic acid affects PYCARD

| 4

(+)-abscisic acid inhibits PYCARD. 4 / 4

| 4

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➶

reach

"These results suggest that ABA suppresses the ASC content through inhibiting its biosynthesis, which is mediated by a reduced ROS production."

22200664

---

➶

reach

"These results suggest that ASC production is inhibited by ABA, as a consequence of a reduced ROS content during seed germination."

22200664

---

➶

reach

"Exogenous application of ABA decreased ASC contents up to 40% in imbibing seeds (XREF_FIG) and, moreover, the inhibition of ASC accumulation by ABA was concentration dependent, similar to APx activity (XREF_FIG)."

22200664

---

➶

reach

"Similar to APx activity, ASC production is also suppressed by ABA application in a concentration dependent manner, revealing the function of ASC and the inhibitory effect of ABA on ASC production during seed germination (XREF_FIG)."

22200664

Zinc atom affects CHUK

| 4

Zinc atom inhibits CHUK. 2 / 2

| 2

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➶

sparser

"For example, the IκB kinase (IKK) members IKKα and IKKβ are inhibited by zinc, albeit at high concentrations of ∼0.5 μM (139)."

31305906

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➶

sparser

"For example, the IκB kinase (IKK) members IKKα and IKKβ are inhibited by zinc, albeit at high concentrations of ∼0.5 µM (139)."

31305906

Zinc atom inhibits CHUK. 2 / 2

| 2

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➶

sparser

"To understand whether zinc selectively inhibits IKKα and/or IKKβ, we exposed IKKβ (−/−) mouse embryonic fibroblast (MEFs) to IL-1β and evaluated NF-κB-mediated function."

23403290

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➶

sparser

"Although recombinant IKKα was inhibited by zinc, IKKβ (−/−) MEFs that contain IKKα did not exhibit zinc-mediated inhibition, indicating that the primary effect of zinc occurs directly through inhibition of IKKβ and/or IKKβ-related kinase complex formation."

23403290

Ruxolitinib affects STAT1

| 4

Ruxolitinib inhibits STAT1. 3 / 3

| 3

---

➶

reach

"There was an over 20-fold difference in the potency of ruxolitinib inhibition of STAT1 and STAT3 phosphorylation (IC 50 of 1.3 x10 -8 M), as compared with STAT5 phosphorylation (IC 50 of 2.8 x10 -7 M) (XREF_FIG)."

28283061

---

➶

reach

"1muM of Ruxolitinib (JAK1/2 inhibitor) and 5muM of Tofacitinib (JAK1/3 inhibitor) suppressed the IL-27-mediated STAT-1, -3 and -5 activation (XREF_SUPPLEMENTARY) without any significant change in cell viability (data not shown)."

28240310

---

➶

reach

"JAK-STAT inhibitor Ruxolitinib selectively inhibits STAT1 and STAT3 activation and increases CTL infiltration to induce a Tc1 and Th1 immune response in the tumor microenvironment in an orthotopic pancreatic cancer mouse model."

28405527

Ruxolitinib inhibits STAT1-E545K. 1 / 1

| 1

---

➶

reach

"Ruxolitinib inhibited in vitro T FH development in response to TGF-beta1, IL-12 and IL-23 leading to a number of CXCR5 + ICOS + T FH -like cells in the STAT1 E545K mutation that was comparable to the control prior to treatment (XREF_FIG)."

28139313

U0126 affects MAPK14

| 4

U0126 inhibits MAPK14. 3 / 3

| 3

---

➶

medscan

"Furthermore, suppression of extracellular signal-regulated kinases and p38 mitogen-activated protein kinase activity by their specific inhibitors, U0126 and SB203580, abrogated CD24-induced proliferation in vitro."

19860845

---

➶

medscan

"Of note, the inhibition of ERK or p38 mitogen-activated protein kinase by U0126 or SB203580, respectively, decreased the apoptosis induced by cisplatin; however, enhanced apoptotic effects were observed with the use of ERK/p38 mitogen-activated protein kinase inhibitor in combination with butein."

26310353

---

➶

medscan

"Downstream signaling routes involve mitogen-activated protein kinase kinase (MEK)1/extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase, as Galectin-1 expression was prevented by U0126 and SB202190."

15663199

U0126 inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Neutrophils were incubated for 6 hrs at normoxia , sustained hypoxia , or 6 cycles of intermittent hypoxia without or with 10 μM U0126 (a specific inhibitor of MEK1/2, which blocks ERK1/2 activation), and 30 μM SB202190 (a competitive inhibitor of the p38 kinase)."

23088735

Sulfasalazine affects IKBKB

2 | 2

Sulfasalazine inhibits IKBKB. 2 / 2

| 2

---

➶

reach

"Sulfasalazine (SSZ), an anti-inflammatory and immunosuppressive agent, inhibits IKKalpha and IKKbeta thereby blocking NFkB activation."

19796605

---

➶

reach

"Sulfasalazine inhibited tumor necrosis factor alpha induced activation of endogenous IKK in Jurkat T cells and SW620 colon cells, as well as the catalytic activity of purified IKK-alpha and IKK-beta in vitro."

11054378

Sulfasalazine inhibits IKBKB. 2 / 2

2 |

---

➶

drugbank

No evidence text available

11054378

---

➶

drugbank

No evidence text available

12950415

Sulfasalazine affects CHUK

2 | 2

Sulfasalazine inhibits CHUK. 2 / 2

2 |

---

➶

drugbank

No evidence text available

11054378

---

➶

drugbank

No evidence text available

12950415

Sulfasalazine inhibits CHUK. 2 / 2

| 2

---

➶

reach

"Sulfasalazine (SSZ), an anti-inflammatory and immunosuppressive agent, inhibits IKKalpha and IKKbeta thereby blocking NFkB activation."

19796605

---

➶

reach

"Sulfasalazine inhibited tumor necrosis factor alpha induced activation of endogenous IKK in Jurkat T cells and SW620 colon cells, as well as the catalytic activity of purified IKK-alpha and IKK-beta in vitro."

11054378

Adenosine 5'-monophosphate affects NLRP3

| 4

Adenosine 5'-monophosphate inhibits NLRP3. 3 / 3

| 3

---

➶

reach

"CD39 expressing DCs converted extracellular ATP to ADP and AMP molecules, which were critical to down-regulate NLRP3 inflammasome and protect the host from experimental autoimmune encephalomyelitis (EAE)."

29033934

---

➶

reach

"Of note, this previous study indicates that inhibition of AMP activated protein kinase (AMPK) can promote NLRP3 inflammasome activation by LPS and FFAs such as palmitate, but not by NLRP3 inflammasome activators used in our study such as ATP and nigericin 4."

27455510

---

➶

reach

"Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition."

28933629

Adenosine 5'-monophosphate bound to NLRP3 inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Soon afterwards, their data demonstrated that neurotransmitter dopamine (DA) could also inhibit NLRP3 inflammasome activation through dopamine D1 receptor (DRD1), suggesting DRD1 signaling could negatively regulate NLRP3 inflammasome via a second messenger cyclic adenosine monophosphate (cAMP), which binds to NLRP3 and promotes its ubiquitination and degradation."

30873162

Zerumbone affects CHUK

| 2 1

Zerumbone inhibits CHUK. 3 / 3

| 2 1

---

➶

medscan

"Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells"

23035900

---

➶

medscan

"Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells."

23035900

---

➶

reach

"Zerumbone suppresses IKKalpha, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells."

23035900

Trichostatin A affects NFKBIA

| 1 2

Trichostatin A inhibits NFKBIA. 3 / 3

| 1 2

---

➶

sparser

"A chromatin immunoprecipitation assay and a promoter-luciferase reporter system confirm that TSA inhibits TF-kappaB but not NF-kappaB activation."

17675290

---

➶

reach

"When we kook at the different studies on HDAC inhibitors, TSA could act at different levels to induce this decreased IkappaBalpha gene expression XREF_BIBR, XREF_BIBR, XREF_BIBR."

22715377

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➶

reach

"Moreover, like butyrate, TSA enhanced IkappaB-alpha degradation."

10734024

Trichostatin A affects MYD88

| 3

Trichostatin A inhibits MYD88. 3 / 3

| 3

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➶

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"TSA inhibited up-regulation of myeloid differentiation primary response protein 88 (MyD88) gene expression in lipopolysaccharide (LPS)-induced bone marrow derived dendritic cells and suberoylanilide hydroxamic acid suppressed mitogen activated protein kinase (MAPK) signaling pathway through acetylation of MAPK phosphatase-1."

27068262

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➶

reach

"Our result suggests that TSA suppresses MyD88 dependent TLR signaling pathway."

27068262

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➶

reach

"TSA attenuated the association of MyD88 with TLR4 and TLR2, not TRIF with TLR4."

27068262

Tofacitinib affects RELA

| 3

Tofacitinib inhibits RELA. 3 / 3

| 3

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➶

reach

"XREF_BIBR In this study, tofacitinib inhibited pSTAT1, pSTAT3 and NFkappaBp65 in PsAFLS and PsA explants, an effect that was paralleled by induction of both SOCS3 and PIAS3."

26353790

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➶

reach

"Furthermore, tofacitinib inhibited NFkappaBp65 in PsA explants and PsAFLS, a key transcriptional factor in the inflamed joint (XREF_FIG E)."

26353790

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➶

reach

"Mechanistically, we demonstrate that tofacitinib suppresses ox-LDL-mediated activation of NF-kappaB inhibitor alpha (IkappaB-alpha), accumulation of nuclear p65 and activation of nuclear factor kappaB (NF-kappaB) promoter, indicating that tofacitinib inhibits NF-kappaB activation."

31284768

Tetracycline affects CASP1

| 3

Tetracycline inhibits CASP1. 3 / 3

| 3

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➶

reach

"Tetracycline inhibited hyperglycemia induced caspase-1 activity in vitro but not in vivo."

17192486

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➶

reach

"Isatin sulfonamides have been described as potent and selective non peptidic caspase-3 and -7 inhibitors [58], but no development has as yet been reported.The second generation tetracycline antibiotic minocycline, sometimes referred to as a caspase inhibitor, reduces caspase-1 and -3 activities, presumably by interfering with the upstream activation of these enzymes."

14980539

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➶

reach

"Minocycline, a tetracycline antibiotic with high CNS penetration when taken orally, inhibits caspase-1 and caspase-3 enzymes and decreases activity of inducible nitric oxide synthase [53]."

12020475

Testosterone affects STAT1

| 3

Testosterone inhibits STAT1. 3 / 3

| 3

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➶

reach

"Testosterone also downregulated directly the INF-gamma/JAK/STAT1 signaling pathway; especially, the mRNA levels of STAT1 and IFNG were reduced in cells treated with testosterone alone (XREF_FIG, p < 0.05, compared to the positive control)."

28665978

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➶

reach

"In this study we investigated whether the testosterone reduces the prostatitis and related mechanism by regulating IFN-gamma and STAT1 signaling pathway."

28665978

---

➶

reach

"Testosterone reduces inflammatory cytokine expression by downregulating the JAK and STAT1 signaling pathway."

28665978

Terbufos affects ITCH

| 3

Terbufos inhibits ITCH. 3 / 3

| 3

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➶

reach

"An important clue to the mechanism for the inhibition of itch by counter stimuli was obtained by examining the effect of silencing glutamate transmission from nociceptive neurons."

25861778

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➶

reach

"The neurons that mediate the suppression of itch by counter stimulation are thought to include a group of inhibitory cells known as B5-I neurons, because they depend on expression of the transcription factor Bhlhb5."

29556030

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➶

reach

"Here we describe the discovery of B5-I neurons, a population of inhibitory interneurons that function to inhibit itch, and review the evidence that these neurons mediate the inhibition of itch by counter stimuli."

25861781

Temozolomide affects RELA

1 | 2

Temozolomide inhibits RELA. 3 / 3

1 | 2

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➶

reach

"We also found that both p-IkappaB and nuclear p65 in U87MG glioma cells were more suppressed by combined PG and TMZ."

29062841

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➶

reach

"Although TMZ reduces binding of p65 to the Bcl XL promoter in control cells, TMZ does not alter p65 binding in p50 deficient cells (XREF_FIG)."

22152481

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➶

ctd

No evidence text available

17638900

Tamoxifen affects RELA

2 | 1

Tamoxifen inhibits RELA. 3 / 3

2 | 1

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➶

ctd

No evidence text available

16497877

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➶

reach

"Inducible deletion of p65 was accomplished by Cre mediated deletion of floxed p65 alleles using a Cre-ERT2 strain and Tamoxifen (XREF_SUPPLEMENTARY)."

23926327

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➶

ctd

No evidence text available

20154269

Superoxide affects CASP1

| 1 1 1

Superoxide inhibits CASP1. 3 / 3

| 1 1 1

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➶

eidos

"An early study showed that in superoxide dismutase 1 ( SOD1 ) - deficient macrophages , higher superoxide production specifically inhibits caspase-1 via thiol glutathionylation of cysteine residues Cys-397 and Cys-362 [ 99 ] ."

32290499

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➶

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"Accordingly, oxidative inactivation of Caspase-1 by superoxide anions (Meissner et al., 2008) and the inhibition of NLPR3 by nitric oxide (Hernandez-Cuellar et al., 2012; Mao et al., 2013; Mishra et al., 2013) have for instance been reported."

27421701

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➶

sparser

"In addition, procaspase-1 could be directly inhibited by superoxide [ xref ]."

25207596

Sunitinib affects RIPK1

3 |

Sunitinib inhibits RIPK1. 3 / 3

3 |

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➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

19654408

Sunitinib affects MAP3K7

2 | 1

Sunitinib inhibits MAP3K7. 3 / 3

2 | 1

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➶

tas

No evidence text available

22037378

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➶

reach

"In addition, the MKI sunitinib, which potently inhibited TAK1 activity (IC50 = 0.16 microM; XREF_FIG), displayed high affinity for TAK1 in situ (XREF_FIG)."

26677977

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➶

tas

No evidence text available

19654408

Sunitinib affects CHUK

3 |

Sunitinib inhibits CHUK. 3 / 3

3 |

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➶

tas

No evidence text available

19654408

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➶

tas

No evidence text available

---

➶

tas

No evidence text available

22037378

Sumatriptan affects ITCH

| 1 2

Sumatriptan inhibits ITCH. 3 / 3

| 1 2

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➶

sparser

"We conclude that sumatriptan inhibits 5-HT-induced itch by activating the peripheral 5-HT1B/1D receptors."

29352328

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➶

reach

"We conclude that sumatriptan inhibits 5-HT-induced itch by activating the peripheral 5-HT1B/1D receptors."

29352328

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➶

reach

"Secondly, sumatriptan effectively blocks dural IScap induced scratching but show no effect in the mouse cheek model of itch."

27058678

Sulfasalazine affects RELA

3 |

Sulfasalazine inhibits RELA. 3 / 3

3 |

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ctd

No evidence text available

15564333

---

➶

ctd

No evidence text available

15955209

---

➶

ctd

No evidence text available

18089796

Strontium(2+) affects ITCH

| 3

Strontium(2+) inhibits ITCH. 3 / 3

| 3

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"Strontium significantly reduced the peak intensity and duration of cowhage induced itch when compared to the control itch curve, and was significantly superior to the other two over-the-counter antipruritic agents and its own vehicle in antipruritic effect."

23474847

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➶

reach

"In addition, creams containing local anesthetics [XREF_BIBR], capsaicin, doxepin [XREF_BIBR], strontium nitrate [XREF_BIBR], or nedocromil sodium [XREF_BIBR] can be helpful to relieve itch."

26064156

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➶

reach

"In an attempt to discover new classes of anti-irritant compounds without anesthetic properties, I observed that topical application of strontium salts to intact skin produced potent suppression of sting, burn, and itch caused by many irritant chemicals."

10491058

Staurosporine affects NFKBIA

| 3

Staurosporine inhibits NFKBIA. 3 / 3

| 3

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➶

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"First, IkappaBalpha expression is reduced in cells treated with staurosporine alone, indicating that the mechanism is partly S100A4 independent."

20507646

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➶

reach

"IkappaBalpha expression was also reduced in cells treated with staurosporine alone."

20507646

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➶

reach

"Staurosporine stimulation failed to induce the detectable degradation of IkappaB-alpha, IkappaB-beta, or p105 (IkappaB-gamma) within the time frame of the observed NF-kappaB activation."

9698090

Staurosporine affects JUN

| 3

Staurosporine inhibits JUN. 3 / 3

| 3

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➶

reach

"The c-jun and c-fos mRNA stimulation elicited by TPA was reduced by the PKC inhibitors, chelerythrine and staurosporine, and could not be mimicked by 4alpha-phorbol 12,13-didecanoate (a phorbol ester that fails to activate PKC), whereas the stimulation induced by EGF was diminished by the PTK inhibitor, genistein."

9177393

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➶

reach

"Moreover, our preliminary data showed that TPA induced free radicals and c-jun were not suppressed by staurosporine (data not shown)."

10535756

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➶

reach

"As shown in Fig. 3, H-89 did not affect C2-ceramide-induced c-jun expression, whereas H-7 and staurosporine strongly inhibit c-jun induction by C2-ceramide."

12135749

Staurosporine affects IKBKE

3 |

Staurosporine inhibits IKBKE. 3 / 3

3 |

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➶

tas

No evidence text available

---

➶

tas

No evidence text available

22037378

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➶

tas

No evidence text available

18183025

Staurosporine affects CHUK

3 |

Staurosporine inhibits CHUK. 3 / 3

3 |

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➶

tas

No evidence text available

22037378

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➶

tas

No evidence text available

19338355

---

➶

tas

No evidence text available

Stattic affects STAT1

| 3

Stattic inhibits STAT1. 3 / 3

| 3

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reach

"STATTIC has a high potency at 37degreesC and does not significantly inhibit other dimeric transcription factors such as c-myc and Max, Jun and Jun, and STAT1 or other important signaling molecules such as Src, JAK1, JAK2, Akt, JNK, and ERK1/2."

25398767

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➶

reach

"Sanseverino et al. found that STATTIC inhibits not only STAT3 activation but also that of STAT1 and to a lesser extent of STAT2, in response to cell activation by IL-6 or IFNbeta based on studies using human monocyte derived dendritic cells."

30283459

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➶

reach

"These findings suggest that Stattic may directly attenuate the STAT1 siRNA effect on E-cadherin expression."

24274066

Sodium(1+) affects RELA

| 3

Sodium(1+) inhibits RELA. 3 / 3

| 3

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➶

reach

"High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide induced NF-kappa B activation."

9467376

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➶

reach

"Compared to the model group, sodium butyrate treatment significantly improved the histopathological changes in the liver and intestine, reduced serum endotoxin and inflammatory cytokines, suppressed HMGB1 and NF-kappaB p65 proteins in liver tissue, and prolonged the survival duration regardless of treatment at 12 hours or 24 hours after induction of ALF (P < 0.05)."

24919615

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➶

reach

"The pre-treatment of cells with pervanadate, a mixture of H 2 O 2 and sodium orthovanadate, abrogated the appearance of the RelA proteolytic product in cell lysates (XREF_FIG, XREF_FIG)."

23684705

Sodium atom affects NLRP3

| 3

Sodium atom inhibits NLRP3. 3 / 3

| 3

---

➶

reach

"In addition, NA inhibited NLRP3 inflammasome activation partly through suppression of ROS."

27614220

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➶

reach

"NA inhibited NLRP3 inflammasome activation and subsequent caspase-1 cleavage as well as interleukin (IL)-1beta secretion."

27614220

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➶

reach

"However, substitution of extracellular Na + with choline did not impair K + efflux or NLRP3 activation elicited by ATP (XREF_FIG C), aerolysin, Al (OH) 3 and silica (XREF_FIG and XREF_SUPPLEMENTARY)."

23809161

Silibinin affects CHUK

| 3

Silibinin inhibits CHUK. 3 / 3

| 3

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➶

reach

"Silibinin inhibited the constitutive activation of NF-kappaB and IKKalpha in PC-3 and DU-145 cells, and blocked stimulated activation of NF-kappaB in LNCaP cells."

22096313

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➶

reach

"Using multiple inhibitors of TNF-alpha and LPS signaling, we found that two inhibitors, silibinin (an inhibitor of IKKalpha) and NSC33994 (a Jak2 inhibitor) possess the ability to inhibit TNF-alpha and LPS induced USP18 expression and proinflammatory effects."

27009955

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➶

reach

"Meanwhile, only two inhibitors potently (> 80%) inhibited USP18 expression as well as IL-1beta mRNA expression in response to LPS stimulation; NSC33994 (an inhibitor of Jak2) and silibinin (an inhibitor of IKKalpha) (XREF_FIG and XREF_FIG and XREF_TABLE)."

27009955

Sevoflurane affects NLRP3

| 3

Sevoflurane inhibits NLRP3. 3 / 3

| 3

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➶

reach

"Sevoflurane attenuates cognitive dysfunction and NLRP3 dependent caspase-1/11-GSDMD pathway mediated pyroptosis in the hippocampus"

32538180

---

➶

reach

"Furthermore, sevoflurane, similar to MCC950, clearly inhibited the OVA induced activity of NLRP3 in the lungs."

30363922

---

➶

reach

"Chikusetsu saponin IVa alleviated sevoflurane induced neuroinflammation and cognitive impairment by blocking NLRP3 and caspase -1 pathway."

32124392

Selenium atom affects RELA

1 | 2

Selenium atom inhibits RELA. 3 / 3

1 | 2

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➶

reach

"Se treatment decreased phosphorylated forms of p65, IkappaBalpha, p38, JNK and ERK in a concentration dependent manner."

29340029

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➶

ctd

No evidence text available

22223226

---

➶

reach

"At protein levels, Western blot analysis demonstrated that selenium dose-dependently decreased NF-kappaB p65 translocating from the cytoplasm to the nucleus."

25231122

Selenium atom affects NLRP3

| 3

Selenium atom inhibits NLRP3. 3 / 3

| 3

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➶

reach

"In this study, we explored whether selenium can inhibit the activation of the NALP3 inflammasome and NF-kappaB and MAPK pathway to achieve anti-inflammatory effects."

30523572

---

➶

reach

"In this experiment, we investigated whether selenium can inhibit the activation of the NLRP3 inflammasome in a mouse model of Staphylococcus aureus induced mastitis."

32436066

---

➶

reach

"Anti-inflammatory effect of selenium on lead induced testicular inflammation by inhibiting NLRP3 inflammasome activation in chickens."

32673849

Salicylic acid affects RELA

| 3

Salicylic acid inhibits RELA. 3 / 3

| 3

---

➶

reach

"High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide induced NF-kappa B activation."

9467376

---

➶

reach

"Inhibition of nuclear factor kappa B subunit p65 mRNA accumulation in lipopolysaccharide stimulated human monocytic cells treated with sodium salicylate."

9467376

---

➶

reach

"The data demonstrate that the p65 subunit of NF-kappa B is inhibited by salicylate treatment and highlight the role of salicylate in the control of gene expression of inflammatory mediators."

9467376

Salicylic acid affects NLRP3

| 3

Salicylic acid inhibits NLRP3. 3 / 3

| 3

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➶

reach

"AICAR and salicylate inhibited NLRP3 induction and caspase-1 activation, and as a result, IL-1beta secretion was reduced."

26196303

---

➶

reach

"Salicylate and AICAR reduced NLRP3 and cleaved caspase-1 expression, and then decreased IL-1beta production."

26196303

---

➶

reach

"These results indicated that ER stress associated NLRP3 inflammasome activation in the endothelium was reduced by salicylate and AICAR.Despite ER stress and inflammasome activation have been demonstrated to be implicated in endothelial dysfunction [13,15,28], the causal link between ER stress and inflammasome activation in the endothelium remains unclear."

26196303

Rottlerin affects RELA

| 2 1

Rottlerin inhibits RELA. 3 / 3

| 2 1

---

➶

medscan

"Adenosine 5'-triphosphateγS-induced p38 MAPK, p42/p44 MAPK, and NF-κB p65 activation were inhibited by Gö6976, Ro-318220, GF109203X, or rottlerin."

23680674

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➶

reach

"The addition of Rottlerin and Bay11-7082 inhibited the nuclear localization of p65 protein empathizing the involvement of PKC and NF-kappaB signaling."

25517939

---

➶

medscan

"In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor."

12493764

Rottlerin affects MAPK8

| 2 1

Rottlerin inhibits MAPK8. 3 / 3

| 2 1

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➶

reach

"Rottlerin, a specific inhibitor of PKC delta, significantly inhibited H (2) O (2)-induced activation of JNK1 in control cells, indicating that PKC delta is involved in the pathway."

12427758

---

➶

medscan

"The Interferon-α-induced activation of JNK1 and the TRAIL promoter was also attenuated by the PKC-δ inhibitor rottlerin."

22435755

---

➶

medscan

"Rottlerin, a specific inhibitor of PKC delta, significantly inhibited H(2)O(2)-induced activation of JNK1 in control cells, indicating that PKC delta is involved in the pathway."

12427758

Resveratrol affects NFKBIA

1 | 2

Resveratrol inhibits NFKBIA. 3 / 3

1 | 2

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➶

reach

"In the normal skin keratinocytes, resveratrol doses (5, 10, and 25muM) blocked UVB mediated (40mJ/cm 2) activation of NF-kappaB, phosphorylation and degradation of IkappaBalpha, and activation of IKKalpha [XREF_BIBR]."

24757666

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➶

reach

"Interestingly, Resveratrol, which blocks MyD88 independent, Toll and IL-1R domain containing adaptor inducing IFN-beta signaling in the TLR4 pathway [XREF_BIBR], inhibited I k Balpha degradation at the early time point, but not at a later time point (30 minutes) after LPS treatment."

19544467

---

➶

ctd

No evidence text available

22363816

Resveratrol affects NFKB1

2 | 1

Resveratrol inhibits NFKB1. 3 / 3

2 | 1

---

➶

ctd

No evidence text available

18222423

---

➶

ctd

No evidence text available

17164350

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➶

reach

"It has been shown that resveratrol inhibits the activation of Nf-kB and subsequently down regulates the expression of Nf-kB regulated genes such as interleukin-2 and Bcl-2, leading to cell cycle arrest and increased apoptosis in multiple myeloma cells."

22673012

Reactive oxygen species affects MAVS

| 3

Reactive oxygen species inhibits MAVS. 3 / 3

| 3

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➶

reach

"The NOD-like protein, NLRX1 and the globular domain of complement 1q receptor (gc1qR) interact with components of oxidative phosphorylation and increase ROS production (Tattoli et al. 2008; Saha et al. 2013) whereas the cytochrome c oxidase complex subunit COX5B, coordinates with the autophagy pathway through autophagy-related gene 5 (ATG5), to suppress MAVS signaling and decrease ROSproduction (Zhao et al. 2012)."

| PMC

---

➶

reach

"Besides, TRX2 inhibits the formation of VISA aggregates by repressing reactive oxygen species (ROS) production, thereby disrupting the assembly of VISA complex."

31915282

---

➶

reach

"Induction of ROS by rotenone induced mitophagy and led to degradation of MAVS in both HEK293T WT and Mavs-(M2-6L) cells; while reduction of ROS by antioxidant propyl gallate (PG) only accumulated MAVS-(M2-6L) in Mavs-(M2-6L) cells (XREF_FIG), suggesting that spontaneously aggregated MAVS was degraded by ROS induced mitophagy."

28607490

Reactive oxygen species affects JUN

| 3

Reactive oxygen species inhibits JUN. 3 / 3

| 3

---

➶

reach

"The BHA 's antioxidant effect is most likely upstream, scavenging ROS, which in turn suppresses c-Jun activation and oxidative DNA damage."

20683948

---

➶

reach

"KRIT1 loss of function causes a ROS dependent upregulation of c-Jun."

24291398

---

➶

reach

"showed that the administration of N-acetylocysteine (NAC), a ROS scavenger, reduced colonic cancer cell apoptosis via inhibition of JNK, p38 MAPK and activation of c-jun."

24798211

Quetiapine affects RELA

| 3

Quetiapine inhibits RELA. 3 / 3

| 3

---

➶

reach

"These results indicated that quetiapine treatment could inhibit the activation of NF-kappaB p65 in APP and PS1 transgenic mice."

25618401

---

➶

reach

"Quetiapine inhibits the activation of nuclear factor kappa B p65 pathway in both transgenic mice and primary microglia stimulated by Abeta 1-42."

25618401

---

➶

reach

"Quetiapine Suppresses the Activation of NF-kappaB p65 Pathway in vivo and in vitro."

25618401

Quercetin affects NFKBIA

| 3

Quercetin inhibits NFKBIA. 3 / 3

| 3

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➶

reach

"The HO-1 inhibitor ZnPP suppressed the inhibitory actions of quercetin on TNFalpha induced atrophic responses and degradation of IkappaB-alpha in myotubes."

29569982

---

➶

reach

"Quercetin suppressed the release of free nuclear factor (NF)-kappaB by preventing degradation of IkappaB-alpha and IkappaB-beta."

11753212

---

➶

reach

"Effect of quercetin on P. intermedia LPS induced IkappaB-alpha degradation."

24040572

Pyrrole-2-carboxylic acid affects JUN

| 3

Pyrrole-2-carboxylic acid inhibits JUN. 3 / 3

| 3

---

➶

reach

"Furthermore, in the same cells, PYC blocked the activation of nuclear factor kappaB (NF-kappaB) and activator protein-1 (AP-1), two major transcription factors centrally involved in IL-1beta gene expression."

11795505

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➶

reach

"XREF_BIBR PYC also inhibits NF-kappaB and activator protein-1 (AP-1), and prevents the degradation of IkappaBalpha (XREF_FIG)."

27777890

---

➶

reach

"Furthermore, in the same cells, PYC blocked the activation of nuclear factor kappa B (NF-kappa B) and activator protein-1 (AP-1), two major transcription factors centrally involved in IL-1 beta gene expression."

11000101

Prostaglandin E2 affects NLRP3

| 3

Prostaglandin E2 inhibits NLRP3. 3 / 3

| 3

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➶

reach

"Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages."

25917098

---

➶

reach

"Prostaglandin E 2 inhibits NLRP3 inflammasome activation through EP4 receptor and intracellular cAMP in human macrophages."

25917098

---

➶

reach

"It has also been shown that prostaglandin E2 can inhibit NLRP3 inflammasome activation by inducing PKA signaling."

29163487

Propofol affects NLRP3

| 3

Propofol inhibits NLRP3. 3 / 3

| 3

---

➶

reach

"Propofol Inhibits NLRP3 Inflammasome and Attenuates Blast Induced Traumatic Brain Injury in Rats."

27696022

---

➶

reach

"Propofol significantly inhibits BK induced increase of NLRP3 inflammasome."

29940605

---

➶

reach

"Propofol up-regulated Nrf2 and down-regulated NLRP3 in VILI model."

32199914

Pregabalin affects ITCH

| 3

Pregabalin inhibits ITCH. 3 / 3

| 3

---

➶

reach

"Gabapentin and pregabalin inhibit the itch associated response induced by the repeated application of oxazolone in mice."

21157120

---

➶

reach

"Pregabalin treatment reduced itch intensity and attack frequency in all patients."

24820863

---

➶

reach

"Similarly, pregabalin significantly reduced mean scores of the 5-D itch scale and the DLQI compared to doxepin."

27397522

Polyinosinic-polycytidylic acid affects IRF3

| 3

Polyinosinic-polycytidylic acid inhibits IRF3. 3 / 3

| 3

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➶

reach

"Auranofin inhibited nuclear factor-kappaB and interferon (IFN) regulatory factor 3 (IRF3) activation induced by polyinosinic-polycytidylic acid (poly [I : C])."

20607500

---

➶

reach

"IPOP inhibited lipopolysaccharide- or polyinosinic-polycytidylic acid induced interferon regulatory factor 3 activation, as well as interferon- inducible genes such as interferon inducible protein-10."

21777518

---

➶

reach

"ILG inhibited interferon regulatory factor 3 activation induced by LPS or polyinosinic-polycytidylic acid, as well as interferon inducible genes, such as interferon inducible protein-10."

20356041

Poly I:C affects NFKBIA

| 3

Poly I:C inhibits NFKBIA. 3 / 3

| 3

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➶

reach

"The antimycotics itraconazole, ketoconazole, luliconazole, terbinafine, butenafine, and amorolfine suppressed the secretion and mRNA expression of TSLP, NF-kappaB activity, and IkappaBalpha degradation induced by poly I : C plus IL-4."

23688403

---

➶

reach

"15d-PGJ 2 was observed to suppress TSLP secretion and mRNA expression, and NF-kappaB activity and IkappaBalpha degradation induced by poly I : C plus IL-4."

23688403

---

➶

reach

"Moreover, poly I : C alone induced IkappaBalpha degradation, leading to NF-kappaB activation, whereas Lp.LTA blocked poly I : C induced IkappaBalpha degradation, suggesting that Lp.LTA reduced NF-kappaB activation."

28983294

Phenethyl caffeate affects NFKB1

1 | 2

Phenethyl caffeate inhibits NFKB1. 3 / 3

1 | 2

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➶

reach

"Reference compounds, herbimycin A (an inhibitor of tyrosine kinase) (18), CAPE (an inhibitor of NF-KB activation) (19), L-NMMA (a non- selective inhibitor of NOS), and GED (an inhibitor of iNOS) potently inhibited nitrite accumulation in the medium."

10834299

---

➶

ctd

No evidence text available

16052512

---

➶

reach

"In addition, Natarajan et al. [12] have demonstrated that CAPE completely and specifically blocks the activation of NFkB induced by a wide variety of inflammatory agents; this inhibitory effect has been recently shown to account for the beneficial effect of this compound in a rat model of vascular injury [9]."

12726888

Pazopanib affects RIPK1

2 | 1

Pazopanib inhibits RIPK1. 3 / 3

2 | 1

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➶

tas

No evidence text available

22037378

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➶

eidos

"In addition , the activity of RIPK1 , an NSP12 interactor which is associated with apoptosis , necroptosis , and inflammatory pathways , is predicted to be inhibited by ponatinib and pazopanib ."

32444466

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tas

No evidence text available

18183025

Pamapimod affects MAPK8

3 |

Pamapimod inhibits MAPK8. 3 / 3

3 |

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➶

tas

No evidence text available

19950901

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➶

tas

No evidence text available

21375264

---

➶

tas

No evidence text available

26704265

Palmatine affects NLRP3

| 3

Palmatine inhibits NLRP3. 3 / 3

| 3

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"Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy mediated NLRP3 inflammasome inactivation."

30496979

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➶

reach

"Moreover, palmatine suppressed NLRP3 inflammasomes activation, but enhanced the expression of the mitophagy related proteins involving LC3, PINK1 and Parkin in colonic tissue of DSS mice."

30496979

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➶

reach

"These effects was consistent with the in vitro data revealing that palmatine inhibited the activation of NLRP3 inflammasomes, while promoted the expression and mitochondrial recruitment of PINK1 and Parkin in THP-1 cell differentiated macrophages."

30496979

Okadaic acid affects ITCH

| 1 2

Okadaic acid inhibits ITCH. 3 / 3

| 1 2

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"Moreover, we describe a novel endogenously present itch response inducer, cyclic phosphatidic acid (cPA), which activates TRPV1 and show that this physiological response, as well as itch produced by histamine, are also inhibited by OA."

27721373

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➶

sparser

"Our experiments show that OA also partially inhibits histamine-induced itch ( xref ; xref ), showing that it is an effective negative regulator of pruritus."

27721373

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reach

"However, when histamine was co-injected with OA (1.25 mugg -1 of weight), a reduction of 58% in the response to histamine was observed (XREF_SUPPLEMENTARY), indicating that OA specifically decreases histamine dependent itch."

27721373

Nitric oxide affects STAT1

| 3

Nitric oxide inhibits STAT1. 3 / 3

| 3

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"Finally, NO donors inhibited nuclear factor-kappa B and STAT-1, but not AP-1 activities in transiently transfected keratinocytes."

12368213

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➶

reach

"Overall, this research indicates that beta-glucan inhibits the production of the NO in the E. coli LPS activated murine macrophages via the HO-1 induction and inhibits the STAT1 signaling pathways."

27488844

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➶

reach

"Furthermore, addition of this NO donor also reduced formation of CD14 ++ CD209 + cells and activation of STAT3 (Y05), STAT3 (S727), and STAT1."

29800237

Nitric oxide affects FOS

| 3

Nitric oxide inhibits FOS. 3 / 3

| 3

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"Nitric oxide donors did not appear to inhibit the induction of c-fos, Egr-1, or other immediate-early genes in response to angiotensin II."

9369252

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➶

reach

"The two pathways exert distinct roles; whereas nitric oxide synthase inhibitors blocked c-fos expression, protein kinase C inhibitors blocked that of Jun D."

12181441

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➶

reach

"Given the similarities between NO and O2, we hypothesized that NO inhibits hypoxia induced up-regulation of c-fos and TH."

10849669

Nickel(2+) affects IRF7

| 3

Nickel(2+) inhibits IRF7. 3 / 3

| 3

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"Nickel decreased interferon regulatory factor (IRF) 3 and IRF7, IKKepsilon, and Sp100."

21466819

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➶

reach

"The present study demonstrated that nickel decreased interferon regulatory proteins IRF3 and IRF7, and activated NF- kappaB, resulting in DeltaNp63 suppression and then p21 up-regulation."

21466819

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➶

reach

"In summary, our results showed that in keratinocytes nickel is able to decrease IRF3 and IRF7, and then activate NF-kappaB."

21466819

Naringin affects RELA

| 3

Naringin inhibits RELA. 3 / 3

| 3

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"Naringin pretreatment of cells significantly inhibited the activation of p65 and NF-kappaB in a concentration dependent manner."

31304904

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➶

reach

"Naringin suppresses NF-kappaB p65 activation in rMC1 cells."

28852447

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➶

reach

"Naringin inhibits inflammatory response, oxidative stress and NF-kappaB p65 activation in diabetic model."

28852447

Myricetin affects NFKBIA

| 1 2

Myricetin inhibits NFKBIA. 3 / 3

| 1 2

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"The data revealed that myricetin (orally twice a day, 100 mg/kg/day, for 6 moths) inhibited the IkappaBalpha and NF-kappaB pathway, with this pathway being independent of nuclear factor erythroid 2 related factor (Nrf2) regulation."

32738903

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➶

eidos

"The data revealed that myricetin ( orally twice a day , 100 mg / kg / day , for 6 moths ) inhibited the IkappaBalpha / NF-kappaB pathway , with this pathway being independent of nuclear factor erythroid 2-related factor ( Nrf2 ) regulation ."

32738903

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reach

"Myricetin decreased NF-kappaB activation by suppressing the degradation of IkappaBalpha, nuclear translocation of p65 subunit of NF-kappaB, and NF-kappaB DNA binding activity in LPS stimulated RAW264.7 macrophages."

27068250

Mycophenolate mofetil affects ITCH

| 3

Mycophenolate mofetil inhibits ITCH. 3 / 3

| 3

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reach

"However, Compared to the control side, local application of MMF significantly reduced the itch and pain scores of the test side skin regardless of the radiotherapy dose and ARD stage (P <.001) during radiotherapy."

31876704

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➶

reach

"Compared to the control side, local application of MMF significantly reduced the itch and pain scores of the test side skin regardless of the radiotherapy dose and ARD stage (P <.001) during radiotherapy."

31876704

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➶

reach

"Compared to the control side, local application of MMF significantly reduced the itch and pain scores of the test side skin regardless of the radiotherapy dose and ARD stage (P <.001) during radiotherapy."

31876704

Morphine(1+) affects DDX58

| 3

Morphine(1+) inhibits DDX58. 3 / 3

| 3

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"We demonstrated that morphine treatment of human blood mononuclear phagocytes significantly inhibited the expression of several key elements (RIG-I, IRF-3, IRF-5, and APOBEC3C/3G) in type I IFN pathway."

20680494

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➶

reach

"Morphine suppresses RIG-I, IFN regulatory factors and APOBEC3."

22359571

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reach

"The further experiments showed that morphine suppressed the expression of several key elements (RIG-I and IRF-7) in IFN signaling pathway."

22359571

Mirtazapine affects ITCH

| 3

Mirtazapine inhibits ITCH. 3 / 3

| 3

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"The antianxiety property of mirtazapine may indirectly reduce itch [XREF_BIBR, XREF_BIBR]."

26240837

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reach

"(71) Although mirtazapine was generally used in conjunction with gabapentin in this case report, other case reports exist of using just mirtazapine to relieve itch in other anti-histamine resistant pruritic dermatoses, suggesting a role for mirtazapine in itch relief beyond just its sedative effects at the H1 receptor."

22285672

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➶

reach

"Similarly, mirtazapine, a noradrenergic and specific serotonergic antidepressant, decreased itch intensity in an uncontrolled case series."

26739556

Minocycline affects NFKBIA

| 3

Minocycline inhibits NFKBIA. 3 / 3

| 3

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"However, minocycline and doxycycline did not significantly suppress phospho-IkappaBalpha."

29124230

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➶

reach

"Moreover, intraperitoneal injection of minocycline (80 mg/kg) reversed BCP induced upregulation of NF-kappaB, p-IKKalpha and IkappaBalpha in spinal cord."

27157092

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➶

reach

"At a cellular level, IkappaBalpha protein levels in mixed hippocampal cells responded rapidly to alcohol in a time dependent manner, and both minocycline and IL-1ra attenuated the elevated levels of IkappaBalpha protein by alcohol."

21276848

Minocycline affects JUN

1 | 1 1

Minocycline inhibits JUN. 3 / 3

1 | 1 1

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"Minocycline inhibited WNV induced apoptosis and suppressed virus induced activation of c-Jun N-terminal kinase (JNK) and its target c-jun."

17872917

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➶

ctd

No evidence text available

17872917

---

➶

sparser

"We show that ethanol activates JNKs which is evident by the increases of their substrate, phosphorylated c-Jun, and more importantly minocycline inhibits ethanol-induced p-c-Jun ( xref )."

29146504

Midostaurin affects TYK2

3 |

Midostaurin inhibits TYK2. 3 / 3

3 |

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➶

tas

No evidence text available

22037378

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➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

19654408

Midostaurin affects JAK1

3 |

Midostaurin inhibits JAK1. 3 / 3

3 |

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➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

19654408

Midostaurin affects IKBKE

3 |

Midostaurin inhibits IKBKE. 3 / 3

3 |

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➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

Midostaurin affects FOS

| 3

Midostaurin inhibits FOS. 3 / 3

| 3

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➶

reach

"CGP 41251 and tamoxifen selectively inhibit mitogen activated protein kinase activation and c-Fos phosphoprotein induction by substance P in human astrocytoma cells."

9372245

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➶

reach

"CGP 41251 inhibits reversibly intracellular PKC activity, induction of c-fos and the corresponding activation of the mitogen activated protein kinase induced by either tumor promoting phorbol esters, platelet derived growth factor, or basic fibroblast growth factor, but not by the epidermal growth factor."

10454207

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➶

reach

"PKC412 inhibits the activity of Ras and FGFR3 or c-fos in concentrations ranging from 0.01 to 50 muM, showing significant therapeutic effects [XREF_BIBR]."

24998287

Methotrexate affects NLRP3

| 3

Methotrexate inhibits NLRP3. 3 / 3

| 3

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"Methotrexate Inhibited NF-kappaB and NLRP3 and Caspase -1 Pathways in Macrophages."

30249062

---

➶

reach

"Chicoric acid prevents methotrexate induced kidney injury by suppressing NF-kappaB and NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO -1 signaling."

31037316

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➶

reach

"We demonstrated that methotrexate might have downregulated the NF-kappaB and NLRP3 and caspase -1 pathways at least partly by intervening the sphingolipid metabolism."

30249062

Melatonin affects RIPK1

| 3

Melatonin inhibits RIPK1. 3 / 3

| 3

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reach

"Further analysis showed that melatonin significantly attenuated APAP induced activation of the serine/threonine kinase receptor interacting protein 1 (RIP1)."

23272189

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➶

reach

"Western blot showed that exposure to FAC resulted in the decrease of anti-apoptotic protein Bcl-2 and the increase of pro apoptotic protein Bax and Cleaved Caspase-3, and necrosis related proteins RIP1 and RIP3, which were significantly inhibited by melatonin treatment."

28415572

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➶

reach

"Likewise, luzindole failed to block melatonin induced the reduction of RIP1 and RIP3 in FAC treated BMSCs."

28415572

Melatonin affects MYD88

| 3

Melatonin inhibits MYD88. 3 / 3

| 3

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"Melatonin therapy attenuates the TLR4 signaling pathway in a MyD88- and TRIF dependent manner, dampening the inflammatory process induced by OC in a preclinical model of ovarian carcinogenesis."

25655081

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➶

reach

"Moreover, our result indicated that melatonin disrupted the formation of TLR4, MyD88, MD2, and CD14 complex."

28238930

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➶

reach

"In addition, melatonin decreased TNBS induced up-regulation of TLR4, MyD88, and NF-kappaB p65, and increased down-regulation of I-kappaB proteins."

30143913

Melatonin affects FOS

| 3

Melatonin inhibits FOS. 3 / 3

| 3

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"Local melatonin infusion at dark-onset inhibited orexin neurons as evident by a significant reduction (66%, p = 0.0004) in the number of orexin neurons expressing c-Fos."

29654707

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➶

reach

"In the ovine pars tuberalis (PT), which displays a high level of MT1 receptors, melatonin inhibits phorbol 12,13 myristate acetate (PMA)-induced and PKC dependent c-fos expression [XREF_BIBR]."

23535335

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➶

reach

"Additionally, melatonin supplement also prevented the decline of c-fos and Arc, the memory associated proteins, measured by Western blot and immunocytochemical staining."

23402899

Mefenamic acid affects NLRP3

| 3

Mefenamic acid inhibits NLRP3. 3 / 3

| 3

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"Flufenamic acid and mefenamic acid inhibit NLRP3 inflammasome activation through the suppression of chloride efflux."

29021150

---

➶

reach

"Studies have shown that, unlike other NSAIDs, fenamates (mefenamic acid, flufenamic acid) selectively inhibit the NLRP3 inflammasome and IL-1beta release via inhibiting the membrane volume regulated anion (Cl -) channel (VRAC), independent of its cyclooxygenase-1 (COX-1) mediated anti-inflammatory activity."

32574259

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➶

reach

"A few NLRP3 inflammasome inhibitors, including sulforaphane, isoliquiritigenin, beta-hydroxybutyrate (BHB), flufenamic acid, mefenamic acid, 3,4-methylenedioxy-beta-nitrostyrene (MNS), parthenolide, BAY 11-7082, INF39, and MCC950, have been developed, but there is no evidence showing that these compounds can specifically and directly inhibit NLRP3 itself."

29021150

Magnesium(2+) affects NLRP3

| 3

Magnesium(2+) inhibits NLRP3. 3 / 3

| 3

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"The molecular mechanisms underpinning these observations suggest that magnesium isoglycyrrhizinate may inhibit NF-kappaB and NLRP3 inflammasome activation to reduce immunological-inflammatory response, which in turn may prevent liver lipid metabolic disorder and accumulation under high fructose condition."

28526339

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➶

reach

"The data presented herein are related to the research article entitled " Magnesium isoglycyrrhizinate blocks fructose induced hepatic NF-kappaB and NLRP3 inflammasome activation and lipid metabolism disorder " (Zhao et al., 2017) XREF_BIBR."

29896493

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➶

reach

"Magnesium isoglycyrrhizinate blocks fructose induced hepatic NF-kappaB and NLRP3 inflammasome activation and lipid metabolism disorder."

28526339

Lycorine affects PYCARD

| 3

Lycorine inhibits PYCARD. 3 / 3

| 3

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"After analysing the ASC content in imbibing seeds it was found that lycorine only at concentration of> 50muM could reduce the ASC content in seeds (XREF_FIG)."

22200664

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➶

reach

"Specifically, a lowering of endogenous ASC content by applications of lycorine (L), an inhibitor of the last enzyme of the ASC de novo biosynthetic pathway, resulted in a lower embryo conversion frequency, as well as a reduced percentage of thymidine and uridine incorporated into nucleotides and nucleic acids."

16740495

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➶

reach

"The results of the pharmacological experiment also show that when the ASC content was effectively suppressed by lycorine, an inhibitor of the ASC biosynthesis pathway, seed germination was reduced (XREF_FIG), together with a reduced expression of GA biosynthesis genes (XREF_FIG)."

22200664

Lipopolysaccharide affects MAPK14

1 | 2

Lipopolysaccharide inhibits MAPK14. 3 / 3

1 | 2

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reach

"In addition, UFH inhibited the LPS induced activation of mitogen activated protein kinase 14, proto-oncogene tyrosine protein kinase Src and nuclear factor kappaB signaling in HUVECs."

29285085

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➶

reach

"siRNA knockdown of MAPK14 and MAPK12, which encode p38-alpha and -gamma respectively, inhibited TNF-alpha production by LPS stimulated macrophages (MAPK14, 31.80 +/- 19.52 SEM%; MAPK12, 21.78 +/- 15.64 SEM%) as did knockdown of SYK (22.50 +/- 16.20 SEM%), but inhibition never exceeded 50%."

25891413

---

➶

ctd

No evidence text available

14997032

Lead atom affects NLRP3

| 3

Lead atom inhibits NLRP3. 3 / 3

| 3

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reach

"The administration of a non specific ROS scavenger, PBN, markedly alleviated mechanical allodynia and inhibited the activation of NLRP3 inflammasome in DRGs and sciatic nerve of the paclitaxel induced neuropathic pain model."

28714351

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➶

reach

"PBN alleviated the mechanical allodynia and inhibited activation of NLRP3 inflammasome in L4-6 DRGs and sciatic nerve after paclitaxel treatment."

28714351

---

➶

reach

"ROS scavenger PBN may attenuate the activation of NLRP3 inflammasomes and thus inhibit paclitaxel induced neuropathic pain."

28714351

Lead atom affects FOS

| 3

Lead atom inhibits FOS. 3 / 3

| 3

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reach

"But the mechanism by which AP-1 and c-Fos activation is inhibited by PBN is not very well understood."

22709256

---

➶

reach

"Inhibition of c-fos activation by PBN may be the key event in protection."

15671265

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➶

reach

"in stroke models showing that PBN can inhibit gene induction of heat shock proteins, c-fos and inducible nitric oxide synthase as well as signal transduction processes in neurodegenerative events."

19678661

Lactate affects MAVS

| 1 2

Lactate inhibits MAVS. 3 / 3

| 1 2

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"Under physiological conditions, the interaction between hexokinase II (HK2), a key rate-limiting enzyme for glycolysis and located on the mitochondrial outer membrane, and MAVS maintains HK2 activity in its basal state, which ensures the operation of glycolysis metabolism and the suppression of MAVS mediated by lactate."

32536927

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➶

sparser

"In order to unravel the underlying mechanism by which lactate inhibits RIG-I-MAVS induced RLR activation, we explored whether lactate impacts the mitochondria localization of MAVS by binding to its TM domain, ( xref )."

31155231

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➶

reach

"Inhibition of lactate generation by oxamate potentiated MAVS mitochondria localization, but lactate add-back compromised this effect (XREF_FIG and XREF_FIG)."

31155231

Kaempferol oxoanion affects NFKB1

| 3

Kaempferol oxoanion inhibits NFKB1. 3 / 3

| 3

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"Additionally, since kaempferol has previously been found to inhibit NFkB, a known mediator of inflammatory signaling XREF_BIBR, we incidentally observed that 15muM kaempferol decreased the phosphorylation of NFkB P65 (P-P65) relative to total P65 in renal tubular cells (N = 3 in each condition, P = 0.022, XREF_FIG)."

28051114

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➶

reach

"At the same time, kaempferol can inhibit the activation of IKKbeta, block the phosphorylation of IkappaBalpha, prevent NF-KB entering into the nucleus, and then decrease the release of inflammatory mediators."

26521440

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➶

reach

"While kaempferol decreased NFkB activation in vivo, we did not see a significant difference in inflammatory genes known to be mediated by NFkB activation (data not shown)."

28051114

Isoliquiritigenin(1-) affects NLRP3

| 1 2

Isoliquiritigenin(1-) inhibits NLRP3. 3 / 3

| 1 2

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reach

"A few NLRP3 inflammasome inhibitors, including sulforaphane, isoliquiritigenin, beta-hydroxybutyrate (BHB), flufenamic acid, mefenamic acid, 3,4-methylenedioxy-beta-nitrostyrene (MNS), parthenolide, BAY 11-7082, INF39, and MCC950, have been developed, but there is no evidence showing that these compounds can specifically and directly inhibit NLRP3 itself."

29021150

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➶

sparser

"Other proposed inhibitors include MCC950 which more specifically targets NLRP3 [ xref ], isoliquiritigenin which also inhibits NLRP3 [ xref ], and CRID3, the cytokine release inhibitor drug which disrupts IL-1β secretion [ xref ]."

31036385

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➶

reach

"XREF_BIBR, XREF_BIBR Isoliquiritigenin has been shown to inhibit ASC oligomerization and activation of the NLRP3 inflammasome in macrophages as well as inflammation in adipose tissue."

27607416

Iron atom affects NFKB1

| 3

Iron atom inhibits NFKB1. 3 / 3

| 3

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➶

reach

"Small Molecule Inhibitors of NFkB Reverse Iron Overload and Hepcidin Deregulation in a Zebrafish Model for Hereditary Hemochromatosis Type 3."

29897731

---

➶

reach

"Also, iron chelators (e.g. desferal) have been shown to inhibit the activation of NFKB by H, Oz (Schreck et al., 1992)."

8707445

---

➶

reach

"Additionally, activation of NF1cB involves activation and production of both protein kinase and reactive oxygen species (Grimm & Baeuerle, 1993), iron deficiency is thought to downregulate protein kinase (Kuvibidila et al., 1991), and iron chelators have been shown to inhibit NFKB activation by HZOZ (Schreck et al., 1992)."

8707445

Iron atom affects EIF2AK1

| 3

Iron atom inhibits EIF2AK1. 3 / 3

| 3

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➶

reach

"In addition to PERK, the eIF2alpha kinase family includes the heme regulated inhibitor (HRI), which is activated by iron or heme deficiency as well as oxidative stress, the general control nonderepressible-2 (GCN2), which is activated by uncharged tRNA caused by amino acid deficiency, and the RNA dependent protein kinase (PKR), which is an interferon (IFN)-inducible protein that becomes activated by binding to double stranded (ds) RNA."

20660158

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➶

reach

"Dietary iron repletion completely reversed ID anemia and ineffective erythropoiesis of Hri -/-, eAA and Atf4 -/- mice by inhibiting both HRI and mTORC1 signaling."

29101239

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➶

reach

"At the appropriate heme iron concentrations under normal conditions, HRI function is suppressed by binding of the heme iron."

18450746

Indole-3-methanol affects RELA

3 |

Indole-3-methanol inhibits RELA. 3 / 3

3 |

---

➶

ctd

No evidence text available

21948866

---

➶

ctd

No evidence text available

16082211

---

➶

ctd

No evidence text available

15811958

Ibrutinib affects NLRP3

| 3

Ibrutinib inhibits NLRP3. 3 / 3

| 3

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➶

reach

"Interestingly, Ito and coworkers [XREF_BIBR] showed that ibrutinib (PCI-32765), a potent BTK inhibitor [XREF_BIBR], suppresses NLRP3 inflammasome signal in a focal brain I/R model."

27127546

---

➶

reach

"Delayed administration of ibrutinib and acalabrutinib attenuated the decline of EF, FS, and FAC caused by CLP and also reduced the activation of BTK, NF-kappaB, and NLRP3 inflammasome."

31552054

---

➶

reach

"Interestingly, Ito and coworkers [XREF_BIBR] showed that ibrutinib (PCI-32765), a potent BTK inhibitor [XREF_BIBR], suppresses NLRP3 inflammasome signal in a focal brain I/R model."

27127546

Ibrutinib affects CASP1

| 1 2

Ibrutinib inhibits CASP1. 3 / 3

| 1 2

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➶

reach

"Being consistent with reduced mature IL-1beta production (XREF_FIG), immunofluorescence staining revealed that ibrutinib treatment strongly suppressed caspase-1 activation in the infarcted area of the brain (XREF_FIG)."

26059659

---

➶

medscan

"Ibrutinib inhibits maturation of IL-1β by suppressing caspase-1 activation in infiltrating macrophages and neutrophils in the infarcted area of ischaemic brain."

26059659

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➶

reach

"Indeed, pro-IL-1beta and caspase-1 processing in primary MoMacs was strongly reduced by both ibrutinib and CGI1746 (Fig 2, F)."

28216434

Hydroxychloroquine affects CASP1

| 3

Hydroxychloroquine inhibits CASP1. 3 / 3

| 3

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➶

reach

"Again, HCQ could not inhibit IL-1beta nor caspase 1 activation triggered by nigericin."

28507328

---

➶

reach

"Caspase 1 activation was also inhibited by HCQ in a dose dependent manner."

28507328

---

➶

reach

"In vitro, HCQ inhibited IL-1beta and caspase 1 activation induced by ATP in a dose dependent manner."

28507328

Hydroxide affects STAT1

| 3

Hydroxide inhibits STAT1. 3 / 3

| 3

---

➶

reach

"We showed that 1,25 (OH) 2 D 3 inhibited pSTAT1 in macrophages, prevented IL-1beta production, and inhibited the ability of macrophages to induce Wnt signaling in tumor cells and to promote their proliferation."

19701245

---

➶

reach

"Although the STAT1 signal reciprocally affects the secretion of IL-10 and IL-17, 1,25 (OH) 2 D 3 inhibits IL-17 production in STAT1 -/- T cells."

20886077

---

➶

reach

"However, a high dose of dietary 25(OH)D 3 supplementation decreased TLR2, TLR9, MyD88, IL6, IL8, IFNλ1, STAT1, MxA, IFNAR1, and TRIF mRNA expression compared with CON-PEDV (Table 7 , p < 0.05)."

31470619

Hydrogen sulfide affects NLRP3

| 3

Hydrogen sulfide inhibits NLRP3. 3 / 3

| 3

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➶

reach

"Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both"

29279328

---

➶

reach

"What is more, a recent study found that hydrogen sulfide may be protective in rats with local cerebral ischemia and reperfusion injury by downregulating the expression of P2X7R [XREF_BIBR, XREF_BIBR], and our ongoing work also found that hydrogen sulfide administration could significantly reduce NLRP3 inflammasome activation and brain injury induced by ICH through suppressing P2X7R expression."

29766811

---

➶

reach

"Hydrogen sulfide attenuates oxidative stress induced NLRP3 inflammasome activation via S sulfhydrating c-Jun at Cys269 in macrophages."

29859240

Hydrogen peroxide affects MAPK14

| 3

Hydrogen peroxide inhibits MAPK14. 3 / 3

| 3

---

➶

medscan

"Stress in the form of TNFalpha and H(2)O(2) treatments rapidly raises the cell content of SIN1 and PCBP2, an effect reversible by inhibiting MAPK14."

18687895

---

➶

medscan

"These results suggests that H2O2 blocks p38 kinase activity through a mechanism that does not decrease activating phosphorylation, probably cysteine oxidation."

21085594

---

➶

medscan

"Hydrogen peroxide inhibits p38 kinase activity but not phosphorylation."

21085594

Homocysteine affects NLRP3

| 3

Homocysteine inhibits NLRP3. 3 / 3

| 3

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➶

reach

"Importantly, Hcy induced activation of NLRP3 inflammasomes and production of IL-1beta and IL-18 were substantially blocked by NLRP3 gene silencing."

28394319

---

➶

reach

"In addition, we found that Hcy activated NLRP3 inflammasomes in VSMCs and SXBX pill could attenuate NLRP3 inflammasomes activation."

30899381

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➶

reach

"SXBX pill suppresses homocysteine induced vascular smooth muscle cells dedifferentiation by inhibiting NLRP3 inflammasomes activation via ERK and p38 MAPK pathways."

30899381

Hexadecanoic acid affects MYD88

| 3

Hexadecanoic acid inhibits MYD88. 3 / 3

| 3

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"In support of this, we found that palmitate induced inflammatory gene expression was substantially reduced in MyD88 deficient macrophages compared with that in control cells, while completely abolished in TLR4 -/- and partially impaired in TLR2 -/- macrophages, suggesting the possible role of saturated fatty acids (SFAs) in promoting TLR-MyD88-dependent switching of ATMs from M2- to M1 like inflammatory macrophages (unpublished data)."

24752299

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"We found that palmitate treatment did not induce degradation of MyD88 and TRIF even in Cbl-b +/+ peritoneal macrophages."

23349502

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➶

reach

"However, palmitate treatment did not induce degradation of MyD88 and TRIF, even in Cbl-b +/+ peritoneal macrophages (XREF_FIG)."

23349502

Haloperidol affects FOS

| 3

Haloperidol inhibits FOS. 3 / 3

| 3

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"Muscarinic receptor antagonists suppressed haloperidol induced c-fos expression throughout the shell and in the mid-level of the core of the nucleus accumbens while A (2) and H (3) receptor antagonists did not.We found that the muscarinic and H (3) receptor antagonists suppress the induction of c-fos by haloperidol in the dorsolateral aspect of the striatum, an area implicated in the development of extrapyramidal motor symptoms following chronic haloperidol treatment."

12044460

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"Haloperidol induced c-fos was augmented in the striatum and pituitary, but reduced in the frontal cortex by chronic lithium treatment."

9165496

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reach

"Globus pallidus lesions inhibit the induction of c-Fos by haloperidol in the basal ganglia output nuclei in rats."

9696058

Glycine betaine affects NLRP3

| 3

Glycine betaine inhibits NLRP3. 3 / 3

| 3

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"Betaine Inhibits NLRP3 Inflammasome Activation."

29881379

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reach

"Recent studies have demonstrated that betaine treatment can significantly inhibit NLRP3 inflammasome related proteins, such as NLRP3 and mature caspase-1, and the levels of pro inflammatory cytokines, including IL-1beta, in a dose independent manner in fructose induced NAFLD models."

29881379

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"Mechanistically, betaine ameliorates sulfur amino acid metabolism against oxidative stress, inhibits nuclear factor-kappaB activity and NLRP3 inflammasome activation, regulates energy metabolism, and mitigates endoplasmic reticulum stress and apoptosis."

29881379

Glucose affects CASP1

| 1 2

Glucose inhibits CASP1. 3 / 3

| 1 2

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"Similar to the effects of 2DG, glucose deprivation inhibited caspase-1 activation and secretions of IL-1beta and IL-18 in wild-type BMDMs in response to LPS and ATP, while TNF secretion was unchanged."

26119735

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➶

medscan

"Similarly, cultured human islets exposed to high glucose- and leptin-induced caspase 1 and JNK inhibition prevented this up-regulation."

18263705

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"Similar to the effects of 2DG, glucose deprivation inhibited caspase-1 activation and secretion of IL-1beta and IL-18 in wild type BMDM in response to LPS and ATP, while TNF secretion was unchanged (XREF_FIG)."

26119735

Genistein affects RELA

| 3

Genistein inhibits RELA. 3 / 3

| 3

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"It was found that NF-kappaB was constitutively active in two human myeloma cell lines examined and that genistein, a chemopreventive agent, down-regulated NF-kappaB in two cell lines as indicated by the electrophoretic mobility gel shift assay and prevented the nuclear retention of p65 as shown by immunocytochemistry."

19107739

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"Although we failed to notice any significant difference in total NF-kappaBp65 in Caco-2 cells (P> 0.05), DSS treatment markedly enhanced nuclear NF-kappaBp65 abundance and genistein reduced nuclear NF-kappaBp65 compared with the DSS group (P < 0.05)."

28977871

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"In this study, genistein reduced nuclear NF-kappaBp65 compared with the DSS group in Caco-2 cells."

28977871

Geldanamycin affects IRF3

| 1 2

Geldanamycin inhibits IRF3. 3 / 3

| 1 2

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"Among these is the Hsp90 inhibitor geldanamycin, which inhibits IRF3 phosphorylation through an unknown mechanism."

21782231

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"Tilorone, tilorone 874, acridine orange and geldanamycin blocked the activation of IRF-3 induced by poly (I : C) but not by LPS, indicating distinct signaling pathways are activated by these stimuli.IL-1 triggers signal through its cognate receptor and transduces it to MyD88, IRAK and TRAF6, as TLR4 does [1]."

12062447

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"Taken together, these results suggest that geldanamycin and 17-AAG inhibit IRF3 activation by preventing MAVS aggregation on the mitochondria."

21782231

Gallic acid affects IFNB1

| 3

Gallic acid inhibits IFNB1. 3 / 3

| 3

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"GA treatment inhibits IFN-beta production by targeting regulatory elements of the IFN-beta promoter."

26601118

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reach

"Our finding that GA prevents IFN-beta synthesis in M2 monocytes is consistent with the earlier demonstration that STAT1 phosphorylation is reduced upon activation in these cells."

26601118

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"16 Taken together, these results demonstrate that GA treatment inhibited IFN-beta production by interfering with activation of transcription factors participating in formation of the IFN-beta enhanceosome."

26601118

Gabapentin affects ITCH

| 3

Gabapentin inhibits ITCH. 3 / 3

| 3

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"Gabapentin and pregabalin inhibit the itch associated response induced by the repeated application of oxazolone in mice."

21157120

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reach

"Anecdotal and limited data suggest that gabapentin, cutaneous field stimulation, serotonin antagonists, and ultraviolet B phototherapy may attenuate itch in some of these patients."

15811075

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"However, there are reports that both itch and pain can be simultaneously reduced, for example by administration of alpha2-adrenoceptor agonists or gabapentin [XREF_BIBR, XREF_BIBR]."

22770638

Forskolin affects JUN

| 3

Forskolin inhibits JUN. 3 / 3

| 3

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"JNKII substantially reduced forskolin stimulated c-Jun accumulation and completely blocked cJun activation (XREF_FIG)."

29073268

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reach

"Forskolin together with 3-isobutyl-1-methylxanthine suppressed c-jun, whereas phorbol 12,13-dibutyrate raised c-jun mRNA levels."

7504996

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reach

"Forskolin together with 3-isobutyl-l-methylxanthine suppressed c-jun, whereas phorbol 12,13-dibutyrate raised c-jun mRNA levels."

7504996

Formic acid affects NLRP3

| 3

Formic acid inhibits NLRP3. 3 / 3

| 3

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"A study by Youm et al. showed that the NLRP3 inflammasome activation was inhibited by the ketone body beta-hydroxybutyrate (BHB) but not by acetoacetate or by related short-chain fatty acids butyrate and acetate [XREF_BIBR]."

27942750

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"As HDAC inhibitors, SCFAs block the activity of the NLRP3 inflammasome and reduce autophagy, thereby alleviating LPS injury in the intestinal barrier.Studies have found that autophagy can directly affect the transcription, processing, and secretion of some cytokines."

31777004

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"There is evidence that ketone bodies, beta-hydroxybutyrate (BHB), but not acetoacetate (AcAc) or the structurally related SCFAs, butyrate and acetate, suppress activation of the Nlrp3 inflammasome in response to urate crystals, ATP and lipotoxic fatty acids XREF_BIBR, XREF_BIBR."

29475132

Flavonoid affects IFIH1

| 3

Flavonoid inhibits IFIH1. 3 / 3

| 3

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"We also discuss the recent progress in the identification of novel chemical inhibitors of nsP13 in the context of our recent discovery of the strong inhibition of the SARS helicase by natural flavonoids, myricetin and scutellarein."

22935448

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"However, increasing concentrations of ATP up to 10mM did not reverse the inhibition of annexin A1 helicase, suggesting that these flavonoids did not inhibit annexin A1 helicase by competing at the ATP binding site."

24269256

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"To extend our observation that the flavonoids, silibinin, genistein and quercetin, do not inhibit annexin A1 helicase by competing at the ATP binding site, we examined their effect on the annealing reaction of annexin A1 helicase which is catalyzed only in the presence of Ca, and does not require ATP ."

24269256

Fexofenadine affects ITCH

| 3

Fexofenadine inhibits ITCH. 3 / 3

| 3

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"Fexofenadine, an H1-receptor antagonist, partially but rapidly inhibits the itch of contact dermatitis induced by diphenylcyclopropenone in patients with alopecia areata."

16556272

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➶

reach

"Cutaneous manifestations in CIU and histamine induced flare and itch in healthy donors were attenuated more extensively by a double dose of fexofenadine HCl compared with a conventional dose."

23534896

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reach

"Fexofenadine reduced the number of wheals, the severity of itch, interference with sleep, and interference with daily activities."

21436982

Febuxostat affects NLRP3

| 3

Febuxostat inhibits NLRP3. 3 / 3

| 3

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"reported that febuxostat inhibited NLRP3 inflammasome activation in the mouse model of metabolic syndrome."

31161887

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"53 Thus, these reports supported our findings that allopurinol and febuxostat inhibited NLRP3 inflammasome activation in the stimulated muscle."

31161887

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reach

"Febuxostat, a Xanthine Oxidoreductase Inhibitor, Decreases NLRP3 dependent Inflammation in Macrophages by Activating the Purine Salvage Pathway and Restoring Cellular Bioenergetics."

31754153

Etoposide affects CHUK

| 3

Etoposide inhibits CHUK. 3 / 3

| 3

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➶

medscan

"On the other hand, etoposide treatment reduces the activity of IκB kinaseα (arrow 2)."

19488402

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➶

medscan

"Longer treatment with etoposide, however, reduces IκB kinaseα activity ( , lanes 4)."

19488402

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➶

medscan

"Since etoposide treatment reduces the level and activity of IκB kinaseα ( ), we examined whether increasing its level could rescue the effects of DNA damage on huntingtin protein."

19488402

Ethidium bromide affects CASP1

| 3

Ethidium bromide inhibits CASP1. 3 / 3

| 3

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"Although not affecting TNF production, EtBr treatment, which reduced mtDNA by ~ 90%, attenuated excessive IL-1beta release by p62 deficient macrophages stimulated with inflammasome activators and inhibited caspase-1 activation."

26919428

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reach

"EtBr treatment dose-dependently inhibited caspase-1 activation IL-1beta cleavage, and the secretion of IL-1beta and IL-18 in response to LPS and ATP treatment, but did not decrease amounts of pro IL-1beta (XREF_FIG)."

21151103

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reach

"Although not affecting TNF production, EtBr treatment, which reduced mtDNA by approximately 90%, attenuated excessive IL-1beta release by p62 deficient macrophages stimulated with inflammasome activators and inhibited caspase-1 activation (XREF_FIG)."

26919428

Ethanol affects RELA

1 | 2

Ethanol inhibits RELA. 3 / 3

1 | 2

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"Acute ethanol exposure suppresses activation of NF-kappaB p65 (RelA), which is critical for LIX expression in MLE-12 cells."

19053978

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reach

"Inhibition of LPS induced p65 translocation has been reported in human monocytes treated with ethanol in vitro, but decreased phosphorylation of p65 (which was not assessed in the present study) was found to be more important [XREF_BIBR]."

19765273

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➶

ctd

No evidence text available

16317704

Ethanol affects NFKB1

1 | 2

Ethanol inhibits NFKB1. 3 / 3

1 | 2

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➶

ctd

No evidence text available

17887948

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➶

reach

"EtOH significantly reduced p50 (34.90 +/-23.70 vs. 197.70 +/-36.43, p < 0.05) not p52 activation."

28848184

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➶

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"32 However, in that study, ethanol preferentially induced the inhibitory p50 and p50 homodimer, and resulted in no induction of the p65 and p50 heterodimer."

11182374

Ethanol affects MAPK8

| 1 2

Ethanol inhibits MAPK8. 3 / 3

| 1 2

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"To clarify the individual role of JNK1 or JNK2 on acute alcohol induced steatosis, either JNK1 knockout or JNK2 knockout mice were treated with acute alcohol."

22749809

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➶

sparser

"Furthermore, alcohol dehydrogenase is involved in the relationship between ethanol-induced inactivation of p-JNK1/2 and the changes of the IGF-I system and cell viability."

18666320

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reach

"In rat heart, direct alcohol feeding led to a reduction of apoptotic cardiomyocyte death by reducing apoptotic signaling cascades, JNK-1 and c-Jun, and activating heat shock protein (HSP) 70, heme oxygenase and superoxide dismutase."

19032583

Ethanol affects JUN

| 3

Ethanol inhibits JUN. 3 / 3

| 3

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"The role of epidermal growth factor receptor in ethanol mediated inhibition of activator protein-1 transactivation."

15878157

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➶

reach

"In rat heart, direct alcohol feeding led to a reduction of apoptotic cardiomyocyte death by reducing apoptotic signaling cascades, JNK-1 and c-Jun, and activating heat shock protein (HSP) 70, heme oxygenase and superoxide dismutase."

19032583

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"In search of an explanation, Diehl (8) showed that previous EtOH exposure inhibited normal regenerative induction of nuclear factor kappa B (NFkappaB) and Jun N-terminal kinase (JNK), and thus compromised balanced induction of toxic and tropic signals observed in RL by the proinflammatory cytokine, tumor necrosis factor (TNF)."

15325497

Endomorphin-2 affects FOS

| 3

Endomorphin-2 inhibits FOS. 3 / 3

| 3

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"Modification of chemical structure increased potency of the new peptides, because analogs of endomorphin-2 and deltorphin II lowered a number of c-Fos positive neurons in the dorsal horn of the spinal cord stronger than the parent peptides.In summary, these results demonstrate that mu- and delta-opioid receptor may similarly modulate the immediate-early gene c-fos, and that the antinociception produced by i.th."

12759135

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"This study indicated that analog of endomorphin-2, Dmt-endomorphin-2 more strongly suppressed c-Fos induction in neurons than endomorphin-2, and its effect was at the same level as that after morphine.Intrathecally administered deltorphin II (15 mug) and ile deltorphin II (15 mug) significantly reduced a number of c-Fos positive neurons by about 28% and 40%, respectively, and an analog of deltorphin II, ile deltorphin II had stronger suppressive effect on the c-Fos induction in comparison with the parent peptide."

12759135

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reach

"In this study, intrathecal injection of morphine (10 mug), endomorphin-2 (5 mug) and Dmt-endomorphin-2 (10 mug) significantly decreased a number c-Fos positive neurons in the laminae I - III in the spinal cord by about 40%, 30% and 40%, respectively."

12759135

Emodin affects JUN

| 3

Emodin inhibits JUN. 3 / 3

| 3

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"Curcumin and emodin block the CSN directed c-Jun signaling pathway, which results in diminished c-Jun steady state levels in HeLa cells."

16083495

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reach

"We further demonstrated that emodin reduced the transcriptional activity of activator protein-1 (AP-1) and nuclear factor kappaB (NF-kappaB), two important nuclear transcription factors involved in MMP-9 expression."

15194008

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reach

"Some findings dictate emodin suppresses the activator protein Activator Protein-1 (AP-1) and NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling [XREF_BIBR, XREF_BIBR] pathways, respectively, thus inhibiting the expression of matrix metallopeptidase 9 (MMP-9) [XREF_BIBR] as shown in XREF_FIG and hence limiting the invasiveness in various cancer cells."

30186863

Drug affects NLRP3

| 3

Drug inhibits NLRP3. 3 / 3

| 3

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"More importantly, an alkaloid drug Colchicine which is known for its effects such as tubulin disruption, alteration of E-selectin distribution on endothelial surfaces, inducing loss of adhesion molecule L-selectins and preventing adhesion and recruitment of neutrophil, has also been shown to inhibit activation of the NLRP3 inflammasome."

32574259

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➶

reach

"Likewise, a sulfonylurea drug Glyburide which is widely used for the treatment of Diabetes type 2, was also shown to inhibit the NLRP3 inflammasome."

32574259

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➶

reach

"NOD2 stimulation by systemic administration of muramyl dipeptide appears to be beneficial in mouse models of colitis.123 Glyburide (glibenclamide), a sulfonylurea drug for the treatment of type 2 diabetes, is known to inhibit ATP-sensitive K+ channels and thus can prevent NLRP3 inflammasome activation.124 Glyburide has been shown to prevent ventilator-induced lung injury in mice and delay endotoxin-induced lethality in mice, but it has not been applied for animal models of colitis.124, 125PRR signaling has significant roles in intestinal homeostasis, which is mainly composed of the maintenance of commensals."

23515136

Doxycycline affects NFKB1

| 3

Doxycycline inhibits NFKB1. 3 / 3

| 3

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"In addition, the study demonstrated that doxycycline treatment causes cell cycle arrest and inhibits NFkB and STAT3 signalling, as our experiments show."

26425660

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➶

reach

"Doxycycline can inhibit the activation of the MAPK and NFkB pathways and protects the corneal epithelial barrier function and conjunctival goblet cells [XREF_BIBR]."

28661456

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➶

reach

"In contrast, NFkB activity was suppressed in both HeLa TET-off and MDR-Off cell lines, suggesting that doxycycline suppresses NFkB activity."

26101157

Doxorubicin affects RELA

| 3

Doxorubicin inhibits RELA. 3 / 3

| 3

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"Isomorellin and doxorubicin and forbesione and doxorubicin treatments suppress NF-kB and p65 activation in CCA cell lines."

25866479

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➶

reach

"Thus, STAT3 activation inhibits doxorubicin mediated p65 nuclear localization, which is contrary to data obtained in untreated cancer cells indicating that STAT3 promotes p65 nuclear retention XREF_BIBR."

23383209

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➶

reach

"Similar to ARF, we found that UV-C, daunorubicin, and doxorubicin repressed the RelA transactivation domain when present as a Gal4 fusion protein."

15053878

Doxorubicin affects IFNB1

| 3

Doxorubicin inhibits IFNB1. 3 / 3

| 3

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"Doxorubicin treatment also significantly inhibited the mRNA induction of IFIT3 (Figure 4D), IFIT1 (Figure 4E), and IFN-β (Figure 4F), all of which depend on the transcriptional activity of IRF3."

32295140

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reach

"Doxorubicin treatment also significantly inhibited the mRNA induction of IFIT3 (XREF_FIG D), IFIT1 (XREF_FIG E), and IFN-beta (XREF_FIG F), all of which depend on the transcriptional activity of IRF3."

32295140

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➶

reach

"Doxorubicin mediated activation of IFN-beta promoter was not impaired by VP35 knockdown."

28377530

Double-stranded RNA affects OAS1

| 3

Double-stranded RNA inhibits OAS1. 3 / 3

| 3

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➶

eidos

"To better understand these drivers of OAS activation , we tested the impact of defined sequence changes within a short dsRNA that strongly activates OAS1 ."

32678884

---

➶

eidos

"These studies reveal that binding orientation-specific activation also exists in solution and that OAS1 activation by short dsRNAs is unexpectedly sensitive to both RNA sequence and the relative organization of activating motifs ."

32678884

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➶

eidos

"Here , the requirements for OAS1 activation by short dsRNAs are explored further using variations on this model 18 bp dsRNA ."

32678884

Dorsomorphin affects NLRP3

| 3

Dorsomorphin inhibits NLRP3. 3 / 3

| 3

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➶

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"Interestingly, compound C significantly attenuated the activation of NLRP3 inflammasome."

31420721

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➶

reach

"In conclusion, compound C was shown to significantly attenuate the NLRP3 inflammasome despite AMPK knockdown, rendering it as the novel target of compound C. Potentially, compound C attenuates NLRP3 inflammasome through the suppression of mitochondrial ROS production."

31420721

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➶

reach

"Compound C attenuates NLRP3 inflammasome despite AMPK knockdown in LPS plus palmitate induced THP-1 cells."

31420721

Dopamine affects FOS

| 3

Dopamine inhibits FOS. 3 / 3

| 3

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"The dopamine D1 antagonist SCH 23390 blocked cocaine induced seizures and associated c-fos induction, but not PTZ induced seizures or Fos."

11421588

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➶

reach

"Furthermore, whisker stimulation evoked c-fos and zif 268 expression in the barrel cortex ipsilateral to the lesion was also attenuated by acute dopamine depletion."

11703467

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➶

reach

"Compared to the unlesioned side, dopamine depletion greatly reduced overall the number of c-Fos stained neurons in the CPu."

24723855

Dioxygen affects RELA

| 3

Dioxygen inhibits RELA. 3 / 3

| 3

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"IL-1beta, 16.6 vs. 55.7 pg/ml, all P < 0.05) [XREF_FIG], and LPS stimulation also induced the nuclear translocation of NF-kappaB p65 subunit, which was blocked by 100% oxygen or 0.5 MAC isoflurane in 60% oxygen [XREF_FIG]."

28345549

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➶

reach

"LPS stimulation led to nuclear translocation of NF-kappaB p65 subunit, which was blocked by 100% oxygen or 0.5 MAC isoflurane in 60% oxygen."

28345549

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➶

reach

"In human PBMCs stimulated by plasma from septic patients, plasma from septic patients also led to nuclear translocation of NF-kappaB p65 subunit, which was also blocked by 100% oxygen or 0.5 MAC isoflurane in 60% oxygen [XREF_FIG]."

28345549

Dioxygen affects NLRP3

| 3

Dioxygen inhibits NLRP3. 3 / 3

| 3

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"Furthermore, BHB decreased reactive oxygen species (ROS) generation, inhibited ROS-NLRP3 pathway in OGD/R treated cells, and suppressed ER stress induced NLRP3 inflammasome activation."

29662437

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➶

reach

"The administration of a non specific reactive oxygen species scavenger, phenyl-N-tert-butylnitrone, markedly alleviated mechanical allodynia and inhibited the activation of NLRP3 inflammasome in L4-6 dorsal root ganglia and sciatic nerve of the paclitaxel induced neuropathic pain model."

28714351

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➶

reach

"Methods : Vascular reactivity, reactive oxygen species (ROS) generation, calcium (Ca 2+) influx and caspase-1 and IL-1beta activation were determined in mesenteric resistance arteries from normoglicemic and streptozotocin induced diabetic C57BL/6 and NLRP3 knockout (Nlrp3 -/-) mice."

32009974

Dioxygen affects CASP1

| 3

Dioxygen inhibits CASP1. 3 / 3

| 3

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"Moreover, UgU elicited mitochondrial superoxide generation in a dose dependent manner, and a specific scavenger of mitochondrial reactive oxygen species (ROS) diminished UgU induced IL-1beta and caspase-1 activation."

28012441

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➶

reach

"Rather, they induced a cellular state inhibitory to both the autoproteolytic and substrate cleavage activities of caspase-1 which was reversed by the reactive oxygen species (ROS) scavenger N-acetyl-cysteine but not by reducing agents or nitric oxide pathway inhibitors."

24337744

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➶

reach

"These results suggest that Phox generated reactive oxygen species downregulate caspase-1, thereby keeping the inflammasome in check and limiting ANCA induced inflammation."

25012177

Dimethyl sulfoxide affects NLRP3

| 3

Dimethyl sulfoxide inhibits NLRP3. 3 / 3

| 3

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"Dimethyl sulfoxide inhibits NLRP3 inflammasome activation."

24380723

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➶

reach

"To confirm whether or not MSM and DMSO inhibit NLRP3 inflammasome activation via mitochondrial ROS generation, we firstly confirmed the effect of DPI, an inhibitor of cytosolic and mitochondrial ROS production [23], on NLRP3 inflammasome activation."

25461402

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➶

reach

"Intriguingly, DMSO was recently found to inhibit the NLRP3 inflammasome XREF_BIBR."

25569799

Dihydrogen affects RELA

| 3

Dihydrogen inhibits RELA. 3 / 3

| 3

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➶

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"The observed increase in amide proton exchange raises the intriguing possibility that the mutant Arg could decrease p65 stability in a region that passes near the NLS polypeptide in the structure of the folded protein."

12460563

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➶

reach

"The ratio of phospho-NF-kappaB p65 to total NF-kappaB p65 was much lower in mice treated with hydrogen rich saline than in untreated mice."

23661516

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➶

reach

"The ratio of phospho-NF-kappaB p65 to total NF-kappaB p65 was much lower in mice treated with hydrogen rich saline than in untreated mice."

23661516

Dihydroartemisinin affects MYD88

| 3

Dihydroartemisinin inhibits MYD88. 3 / 3

| 3

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"Consequently, the recruitment of adaptors, MyD88 and TRIF, to TLR4 is attenuated in cells treated with DHA, leading the diminished expression of inflammatory genes such as TNF-alpha and COX-2."

27085899

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➶

reach

"In the PMEC experiment, compared with the control, increased mRNA abundances of Toll like receptor (TLR) -4 downstream target, myeloid differentiation factor 88 (MyD88), IL-6 and IL-8 were observed in LPS treatment, whereas DHA appeared to decrease mRNA abundances of MyD88, IL-6 and IL-8 induced by LPS."

27938408

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➶

reach

"DHA also suppressed NFkappaB activation induced by TLR4 (CA), but not MyD88 (CA) or AKT (CA), suggesting that the molecular targets of DHA are signaling components upstream of MyD88 and AKT."

12865424

Dihydroartemisinin affects CHUK

| 3

Dihydroartemisinin inhibits CHUK. 3 / 3

| 3

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➶

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"As shown in XREF_SUPPLEMENTARY, DHA reduced Cdk4, Cdk6, VEGF, IKKalpha, and Rac1 levels compared to the control group."

27613829

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➶

reach

"We discovered that DHA directly inhibits IkappaBalpha kinase beta (IKKbeta) and IKKalpha enzymatic activity in vitro, whereas AA did not have this effect."

15254232

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➶

reach

"AA quenches ROS intermediates involved in the activation of NF-kappaB and is oxidized to DHA, which directly inhibits IKKbeta and IKKalpha enzymatic activity."

15254232

Dexmedetomidine affects NLRP3

| 3

Dexmedetomidine inhibits NLRP3. 3 / 3

| 3

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"Dexmedetomidine promotes liver regeneration in mice after 70% partial hepatectomy by suppressing NLRP3 inflammasome not TLR4 and NFkappaB."

29100037

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➶

reach

"Dexmedetomidine inhibits the NF-kappaB pathway and NLRP3 inflammasome to attenuate papain induced osteoarthritis in rats."

31545916

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➶

reach

"Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats."

30232232

Dexamethasone affects NFKBIA

| 3

Dexamethasone inhibits NFKBIA. 3 / 3

| 3

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"In contrast, 1pM cortisone or dexamethasone decreased p-PKB (Ser473) to PKB ratio, increased p-IkappaBalpha to IkappaBalpha ratio, and increased nuclear NF-kappaB subunit p50."

25734515

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➶

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"Dexamethasone prevents interleukin-1beta-induced nuclear factor-kappaB activation by upregulating IkappaB-alpha synthesis, in lymphoblastic cells."

12745547

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➶

reach

"In primary cultures of Leydig cells, 10 -9 and 10 -7 M dexamethasone decreased levels of NR4A1 and NR5A1 mRNAs and increased those of NFKBIA mRNA."

30801912

Dexamethasone affects NFKB1

| 3

Dexamethasone inhibits NFKB1. 3 / 3

| 3

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"Dexamethasone suppressed NF-KB activation in the steroid- resistant patients as well as in the steroid responsive patients, but steroid induced inhibition of another transcription factor (activation protein [AP]-1) was deficient in the steroid resistant patients."

9265727

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"In this study we demonstrate that dexamethasone, which reduces the production of ceramide, significantly inhibits TNF-alpha-induced activation of NF-KB, c-Jun N-terminal kinase, also known as stress activating protein kinase, caspase-3-like cysteine protease, redistribution of cytochrome c, and apoptosis in MC3T3E1 osteoblasts."

10919278

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"In airway epithelial cell lines, we confirmed that NFKB1 and IRF1 were consistently down-regulated by dexamethasone treatment at 6 hours."

25564375

Dexamethasone affects FOS

| 3

Dexamethasone inhibits FOS. 3 / 3

| 3

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"High-dose dexamethasone prevented c-fos induction in cerebral regions sensitive to HI."

8681202

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➶

reach

"Dexamethasone inhibited c-Fos, inhibitor of DNA binding 3, and pSTAT3 but not pSTAT5 and MEK."

28433687

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➶

reach

"This observation may be related to the finding that WAS+DSS treatment increases circulating corticosterone to a larger extent than WAS or DSS alone, given that dexamethasone inhibits c-Fos induction by stress and inflammatory pain."

26217204

D(pT)3 affects TLR7

| 3

D(pT)3 inhibits TLR7. 3 / 3

| 3

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"In this study we demonstrate that poly (T) ODNs can inhibit TLR7 and enhance TLR8 signaling events involving NF-kappaB activation in HEK cells and cytokine production (IFN-alpha, TNF, and IL-12) by human primary PBMC."

17114492

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reach

"Nevertheless, in combination with imidazoquinolines such as resiquimod or CL075, poly(dT) increases TLR8 mediated signaling and abolishes TLR7 mediated signaling [256,257]."

32203790

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reach

"For example, poly (T) ODNs inhibited TLR7 activation but enhanced TLR8 signaling by imidazoquinoline derivatives optimized to trigger either TLR7 or TLR8."

28392787

Cysteine affects NLRP3

| 3

Cysteine inhibits NLRP3. 3 / 3

| 3

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"It was found that ebselen, a putative ONOO - scavenger, failed to decrease formation and activation of NLRP3 inflammasomes in podocytes treated with Hcys, suggesting ONOO - may not play a critical redox role in this particular pathological process in podocytes."

24140862

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"Reduction of intracellular O 2 *- and H 2 O 2 levels prevented Hcys induced NLRP3 inflammasome formation in podocytes."

24140862

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reach

"The * OH scavenger TMTU did not significantly inhibit any measure of Hcys induced NLRP3 inflammasome formation or activation, suggesting that in comparison to O 2 *- and H 2 O 2, * OH does not play a crucial role to inflammasome stimulation."

24140862

Cyclosporin A affects NLRP3

| 3

Cyclosporin A inhibits NLRP3. 3 / 3

| 3

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"Cyclosporine A (CsA) strongly inhibits NLRP3 inflammasome activation, but this inhibition may be independent of its effects on cyclophilin D (CypD)-mediated MPT."

25879282

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➶

reach

"Cyclosporin A (a cytochrome c inhibitor) could significantly inhibit NLRP3 inflammasome activation and mature IL-1beta secretion, while the ROS level was not influenced."

29993180

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➶

reach

"Cyclosporine A (CsA) strongly inhibits NLRP3 inflammasome activation, but this inhibition may be independent of its effects on cyclophilin D (CypD)-mediated MPT."

25879282

Curcumin affects TICAM1

| 3

Curcumin inhibits TICAM1. 3 / 3

| 3

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"If IKKbeta is the only target of curcumin, curcumin should not inhibit LPS (TLR4 agonist)-induced activation of TRIF pathway of TLR4."

16678799

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➶

reach

"Therefore, curcumin inhibits LPS induced activation of both MyD88- and TRIF dependent pathways of TLR4 resulting in the inhibition of both NF-kappaB and IRF3."

16678799

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➶

reach

"However, it is not known whether curcumin inhibits TRIF dependent pathway or not."

16678799

Curcumin affects MAPK14

| 2 1

Curcumin inhibits MAPK14. 3 / 3

| 2 1

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➶

medscan

"On the other hand, curcumin attenuates the gefitinib-induced damage on intestinal epithelial cells through modulating p38 kinase activation and cell apoptosis."

21858220

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➶

medscan

"We showed that curcumin attenuated the gefitinib-induced cell proliferation inhibition and apoptosis through altering p38 mitogen-activated protein kinase activation in intestinal epithelia cell."

21858220

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reach

"On the other hand, MAPK1, MAPK14, PTK2, and VEGFA were downregulated by curcumin treatment and enriched in the VEGF pathway."

26273408

Curcumin affects IRF3

| 3

Curcumin inhibits IRF3. 3 / 3

| 3

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"However, curcumin did not inhibit interferon regulatory factor 3 (IRF3) activation induced by another immediate TLR4 downstream component TIR-domain-containing adaptor inducing interferon-beta (TRIF), suggesting that the target of curcumin is the receptor itself, but not the downstream components of TRIF pathway [XREF_BIBR]."

21631512

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➶

reach

"Curcumin inhibited DeltaTLR4 induced NF-kappaB and IRF3 activation."

16678799

---

➶

reach

"However, in TRIF dependent pathway, curcumin did not inhibit IRF3 activation induced by overexpression of TRIF in 293T cells."

16678799

Cortisol affects STAT1

| 3

Cortisol inhibits STAT1. 3 / 3

| 3

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➶

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"In addition, hydrocortisone treatment decreased IRF9 and STAT1 mRNA synthesis when measured by qPCR, which was also seen at the protein level in Fig."

32430515

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➶

reach

"In addition, hydrocortisone treatment decreased IRF9 and STAT1 mRNA synthesis when measured by qPCR (Fig. 1f ) , which was also seen at the protein level in Fig. 1d ."

32430515

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reach

"In our pulmonary endothelial cell cultures, we observed that, the use of hydrocortisone for one day reduced the mRNA synthesis of IRF9 and STAT1 -the components of the ISGF3 complex.The effect was not due to the downregulation of IFN alpha/beta receptor."

| DOI

Cortisol affects ITCH

| 3

Cortisol inhibits ITCH. 3 / 3

| 3

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"The 1% hydrocortisone reduced peak itch intensity by 0.36 +/-0.42 VAS units, equivalent to a 5.5% reduction (ns); duration of itch by 50.2 +/-33 seconds, equivalent to a 12.3% reduction (ns); and total itch perceived (AUC) by 6.2% (ns) (XREF_FIG)."

25941445

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"In comparison to placebo, 2.5% hydrocortisone significantly (p = 0.03) reduced itch duration from 12.6 +/- 11.0 min (mean +/- SD) to 8.6 +/- 8.2 min (the reducing rate was 32%) as well as itch magnitude (at minutes 3, 6, 7 and overall)."

11096377

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"14 A small pilot study in patients with pruritus from undefined etiologies demonstrated that topical application of hydrocortisone acetate 2.5% and pramoxine hydrochloride 1% in a hydrolipid lotion reduced pruritus by 30% from baseline as rated by patients using the visual analog scale within 24 hours of initiation of therapy."

21767774

Cortisol affects IRF9

| 3

Cortisol inhibits IRF9. 3 / 3

| 3

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"In addition, hydrocortisone treatment decreased IRF9 and STAT1 mRNA synthesis when measured by qPCR (Fig. 1f ) , which was also seen at the protein level in Fig. 1d ."

32430515

---

➶

reach

"In addition, hydrocortisone treatment decreased IRF9 and STAT1 mRNA synthesis when measured by qPCR, which was also seen at the protein level in Fig."

32430515

---

➶

reach

"In our pulmonary endothelial cell cultures, we observed that, the use of hydrocortisone for one day reduced the mRNA synthesis of IRF9 and STAT1 -the components of the ISGF3 complex.The effect was not due to the downregulation of IFN alpha/beta receptor."

| DOI

Coenzyme Q10 affects NLRP3

| 3

Coenzyme Q10 inhibits NLRP3. 3 / 3

| 3

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"In parallel, CoQ10 inhibits NLRP3 inflammasome activation and systemic inflammatory response after burn injury."

30761259

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➶

reach

"Coenzyme Q10 serves to couple mitochondrial oxidative phosphorylation and fatty acid beta oxidation, and attenuates NLRP3 inflammasome activation."

30003820

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➶

reach

"These data indicate that CoQ10 mitigates mitochondrial dysfunction and thereby inhibits NLRP3 inflammasome activation and systemic inflammatory response after burn injury."

30761259

Cisplatin affects RELA

| 3

Cisplatin inhibits RELA. 3 / 3

| 3

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"IHC studies showed reduced p65 staining in tumors of animals treated with 19 and cisplatin individually and the combination (XREF_FIG)."

27077228

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➶

reach

"Moreover, mutation of RelA at T505 abolished cisplatin mediated repression of the RelA TAD in luciferase reporter assays."

21737676

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➶

reach

"As shown in XREF_FIG, cisplatin induced p65 nuclear translocation was significantly reduced by betaL coadministration."

24025646

Chrysophanol affects NLRP3

| 3

Chrysophanol inhibits NLRP3. 3 / 3

| 3

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"Chrysophanol could inhibit the activation of NALP3 inflammasome and protect cerebral ischemic stroke."

24876671

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➶

reach

"Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia and Reperfusion in Mice."

24876671

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➶

reach

"Immunoglobulin treatment, intermittent fasting, and intraperitoneal injection of the fungal isolate chrysophanol, all attenuate NLRP3 inflammasome activity and have been shown to reduce ischemic brain damage [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

26473731

Chondroitin sulfate affects CASP1

| 3

Chondroitin sulfate inhibits CASP1. 3 / 3

| 3

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"Caspase-1 activation by IL-32 or LPS was decreased by the treatment of BT or CS."

23190696

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➶

reach

"Once again, this showed that caspase-1 activity was significantly inhibited by the treatment of BT or CS."

23190696

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➶

reach

"In this study, we showed that BT or CS significantly inhibited the production of TSLP, activation of caspase-1 and NF-kappaB, and differentiation of monocytes in THP-1 cells."

23190696

Cetirizine affects ITCH

| 3

Cetirizine inhibits ITCH. 3 / 3

| 3

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"Both VA and cetirizine significantly reduced type I hypersensitivity itch in patients with AD, compared with both placebo and NI."

22313287

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➶

reach

"Both VA and cetirizine significantly reduced type-I-hypersensitivity itch in AD patients, compared to both placebo and NI."

22313287

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➶

reach

"Cetirizine reduced focal itch but failed to influence the alloknesis phenomenon."

10091477

Celastrol affects STAT1

| 3

Celastrol inhibits STAT1. 3 / 3

| 3

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"Previous studies have demonstrated that JNK is involved in poly (I : C)-induced STAT1 activation, and we found that celastrol suppressed poly (I : C)-induced activation of STAT1."

28027722

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➶

reach

"In addition, celastrol significantly suppressed poly (I : C)-induced activation of JNK MAPK and STAT1 signaling pathways."

28027722

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➶

reach

"Pre-loading celastrol for 30 min could inhibit the actions of MEK1, ERK1, NF-kappaB (p65), and STAT1, but not p38 (XREF_FIG)."

25116125

Celastrol affects NFKB1

| 3

Celastrol inhibits NFKB1. 3 / 3

| 3

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"We also found that celastrol inhibited the Akt and GSK3beta and Akt and NFkB survival pathway."

25818165

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➶

reach

"Finally, drugs that can potentially accelerate or attenuate aging include celastrol, which was reported to indirectly inhibit NFKB signaling [XREF_BIBR, XREF_BIBR], and radicicol, which is potentially a HSP90 and topoisomerase inhibitor [XREF_BIBR]."

27846806

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"We have recently shown that either the induction of Hsp70 via pharmacological inhibition of NFkB by celastrol, or addition of exogenous recombinant human Hsp70 offers protection against oxidative stress and suppresses inflammation in RPE cells."

26344735

Carboplatin affects RELA

1 | 2

Carboplatin inhibits RELA. 3 / 3

1 | 2

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"Carboplatin treatment downregulated constitutive NF-kappaB activity and prevented nuclear retention of p65."

15120608

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➶

reach

"Carboplatin treatment downregulates constitutive NF-kappaB activity and prevents nuclear retention of p65 in liver cancer [XREF_BIBR] and glioma cell lines [XREF_BIBR]."

18414584

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➶

ctd

No evidence text available

15120608

Carbamazepine affects FOS

| 3

Carbamazepine inhibits FOS. 3 / 3

| 3

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"MK-801 or carbamazepine, which prevented hypoxia-ischemia-induced seizures, also prevented c-fos induction in the non ligated hemisphere while MK-801 was associated with increased c-fos induction in hippocampal neurones from the ligated side, as well as in glial like and ependymal cells."

2126969

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"Single intraperitoneal injection of carbamazepine (50 mg/kg), valproate (300 mg/kg) or intravenous injection of phenytoine (20 mg/kg) before noxious stimulation reduced the number of c-Fos immunoreactive neurons to 65-80% of control levels in superficial laminae and to 30-60% in deep laminae of the dorsal horn."

7789465

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➶

reach

"The high c-fos expression observed in the dentate gyrus is consistent with c-fos expression patterns observed in rats after strong, unilateral electrical stimulation of the hippocampus via an implanted electrode in animals treated with carbamazepine, which prevents seizures and also prevents bilateral c-fos staining upon unilateral stimulation."

28575667

Calcium(2+) affects STAT1

| 3

Calcium(2+) inhibits STAT1. 3 / 3

| 3

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"RESULTS: Emodin restored the cell viability in poly I: C-induced RAW 264.7 at concentrations of up to 50 μM. Emodin significantly inhibited the production of nitric oxide, IL-1α, IL-Ιβ, IL-6, GM-CSF, G-CSF, M-CSF, MCP-1, MIP-1a, MIP-Ιβ, MIP-2, RANTES, and IP-10 as well as calcium release and mRNA expression of signal transducer and activated transcription 1 (STAT1) in poly I:C-induced RAW 264.7 (P < 0.05)."

28480427

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➶

reach

"These affirm Type I IFN antagonism of JEV NS5 correlating with downregulation of calreticulin in which activated Ca 2+ -dependent calcineurin phosphatase inhibits STAT1-mediated signaling."

24166946

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➶

reach

"Results: Emodin restored the cell viability in poly I:C-induced RAW 264.7 at concentrations of up to 50 μM. Emodin significantly inhibited the production of nitric oxide, IL-1α, IL-1β, IL-6, GM-CSF, G-CSF, M-CSF, MCP-1, MIP-1α, MIP-1β, MIP-2, RANTES, and IP-10 as well as calcium release and mRNA expression of signal transducer and activated transcription 1 (STAT1) in poly I:C-induced RAW 264.7 (P < 0.05)."

28480427

Caffeine affects FOS

| 1 2

Caffeine inhibits FOS. 3 / 3

| 1 2

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"Co-administration of the A2a receptor antagonist 8-(3-chlorostyryl) caffeine (5 mg/kg) with quinpirole (0.05 mg/kg) also attenuated striatal c-Fos induction following reserpine to a greater extent than 0.05 mg/kg quinpirole alone."

8577368

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➶

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"Among rats exposed to an acute caffeine challenge, chronic caffeine treatment decreased numbers of c-Fos (PC-38)-ir/Tph2-immunonegative cells within the DRD at -7.46 mm bregma in addition to the DRV at every rostrocaudal level studied."

30579884

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➶

medscan

"Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway."

20432471

Cadmium atom affects NFKBIA

| 3

Cadmium atom inhibits NFKBIA. 3 / 3

| 3

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"As shown in Fig. 4 A, Cd enhanced the serine 536 phosphorylated NF-kappaB and serine32 phosphorylated I-kappaBalpha and caused the degradation of IkappaBalpha in ECV304 cells."

26514923

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➶

reach

"Low-dose Cd (4 muM) activates NF-kappaB by promoting the degradation of IkappaBalpha in human renal glomerular endothelial cells [XREF_BIBR]."

28388546

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➶

reach

"Interestingly, Cd did not trigger the degradation of IkappaBalpha, suggesting that Cd induced ICAM-1 expression is mediated through IkappaBalpha degradation independent pathway."

15240131

Bumetanide affects ITCH

| 3

Bumetanide inhibits ITCH. 3 / 3

| 3

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"In study 1, nedocromil sodium, frusemide and bumetanide reduced itch scores by 36%, 48% and 34%, respectively, and flare areas by 17%, 26% and 15% respectively (all P < 0.05)."

15005740

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➶

reach

"Moreover, the NKCC1 antagonist bumetanide inhibits itch and flare responses to histamine in human skin, and attenuates phase I and II behavioral responses in the formalin model of tissue injury induced pain [XREF_BIBR]."

18799000

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➶

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"In human skin, bumetanide and furosemide, both of which block NKCC1, inhibit itch and flare responses to histamine."

19167425

Bilirubin IXalpha affects IFNB1

| 3

Bilirubin IXalpha inhibits IFNB1. 3 / 3

| 3

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"Bilirubin, but not SOD, blocked the cellular production of interferon-beta, while interleukin-6 production remained unaffected."

26163808

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➶

reach

"Nevertheless, our data clearly show that bilirubin disrupts TLR4 dependent Nox activation and interferon-beta production, which likely represents the molecular mechanism (s) underlying its inhibitory effect on iNOS expression in response to LPS."

26163808

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➶

reach

"Bilirubin also suppresses interferon-beta release via a ROS independent mechanism."

26163808

Beta-lapachone affects NFKBIA

| 3

Beta-lapachone inhibits NFKBIA. 3 / 3

| 3

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"These results indicate that beta-lapachone blocks NF-kappaB activation by blocking IkappaBalpha degradation.Because the p65 subunit of NF-kappaB also must be translocated to the nucleus for NF-kappaB to be activated, we measured the level of p65 in the cytoplasm and nucleus."

10075082

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➶

reach

"On the other hand, TNF mediated degradation of IkappaBalpha was abolished in cells treated with beta-lapachone."

10075082

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➶

reach

"To determine whether the inhibitory action of beta-lapachone is due to its effect on IkappaBalpha degradation, cells were treated with beta-lapachone for 2 hr and next with TNF for different times."

10075082

Beta-D-glucose affects NFKBIA

| 3

Beta-D-glucose inhibits NFKBIA. 3 / 3

| 3

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"GW0742 prevented zymosan induced IkappaB-alpha degradation, with IkappaB-alpha levels observed in these animals similar to those of the sham group."

20167109

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➶

reach

"Zymosan induced IkappaBalpha degradation in both CD1c+ DCs and CD14hi monocytes."

26037552

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➶

reach

"Endophilin II and/or MNSFbeta siRNA enhanced zymosan induced IkappaBalpha degradation."

20849826

Baicalin affects TLR7

| 3

Baicalin inhibits TLR7. 3 / 3

| 3

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"Wan and colleagues [XREF_BIBR] demonstrated that baicalin inhibits TLR7 and MYD88 signaling pathway activation to suppress lung inflammation in mice infected with influenza A virus."

29849712

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➶

reach

"Baicalin inhibits TLR7 and MYD88 signaling pathway activation to suppress lung inflammation in mice infected with influenza A virus."

24748990

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➶

reach

"In conclusion, baicalin effectively reduced the pathological damage and inflammation of the lungs by downregulating the TLR7 and MYD88 mediated signaling pathway."

24748990

Azithromycin affects TLR7

| 3

Azithromycin inhibits TLR7. 3 / 3

| 3

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"In another study, Huang et al found that azithromycin inhibits TLR7 signaling in dendritic cells and improves the imiquimod-induced Psoriasis-like cutaneous inflammation in mice 19 ."

| PMC

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➶

reach

"Azithromycin impairs TLR7 signaling in dendritic cells and improves the severity of imiquimod induced psoriasis like skin inflammation in mice."

27449383

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➶

reach

"Azithromycin inhibited lysosomal acidification and the proteolytic processing of TLR7, thereby blocking imiquimod induced NF-kappaB and IRF7 activation in DCs [XREF_BIBR]."

28894754

Atorvastatin affects RELA

| 3

Atorvastatin inhibits RELA. 3 / 3

| 3

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"Although serum MCP-1 and MIF concentrations were not changed by either statins, atorvastatin administration increased PPAR-alpha and -gamma mRNA abundances and decreased NF-kappaB p50, p65, MCP-1 and TNF-alpha mRNA abundances in atherosclerotic lesions."

21481872

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reach

"Atorvastatin inhibits activation of NFkappaB3 and p65 (RELA) XREF_BIBR, XREF_BIBR, NFkappaB complex XREF_BIBR, XREF_BIBR and STAT1 XREF_BIBR which are transcription factors that activate the transcription of CXCL10 gene to mRNA XREF_BIBR - XREF_BIBR (XREF_FIG)."

23630573

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➶

reach

"Atorvastatin inhibits TREM-2, NF-kappaB p65, and p-IkappaB-alpha protein expression in OVA induced asthmatic mouse lungs."

28810543

Arsenite(3-) affects EIF2AK1

| 3

Arsenite(3-) inhibits EIF2AK1. 3 / 3

| 3

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"Although arsenite also inhibits translation by activating the eIF2alpha kinase HRI, arsenite induced mRNA stabilization can be observed under HRI depleted conditions."

25446091

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➶

reach

"Heme depletion, arsenite-induced oxidative stress, heat shock, and osmotic stress activate the eIF2a kinase HRI, while amino acid deprivation or UV light activates GCN2 (Lu et al., 2001; Deng et al., 2002) ."

23084916

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➶

reach

"EIF2alphaK1/HRI (Heme-Regulated Inhibitor) is activated by heat shock or arsenite –a known inductor of oxidative stress– [86], [87]."

20813183

Arachidonic acid affects IKBKB

| 3

Arachidonic acid inhibits IKBKB. 3 / 3

| 3

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"In the cell free hotspot kinase assay, the CA, AA and UA inhibited human IKKbeta."

25938234

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➶

reach

"As can be seen in XREF_FIG, AA significantly inhibited the activity of IKKbeta, with a maximum inhibition of 68% at the highest concentration tested (50 microgmL -1)."

21152019

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➶

reach

"AA significantly inhibited the activity of IKKbeta, which, along with IKKalpha comprise the catalytic part of the IKK complex XREF_BIBR."

21152019

Apocynin affects STAT1

| 3

Apocynin inhibits STAT1. 3 / 3

| 3

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"Finally, apocynin inhibited the activation of signal transducers and activators of transcription 1 (STAT1) and nuclear factor kappa B (NF-kappaB) pathways, two key regulatory factors for microglial M1 inflammatory responses, in paraquat and maneb treated mice."

30798073

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➶

reach

"Apocynin also inhibited the activation of JAK1/2 and STAT1."

28751937

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➶

reach

"3.6 Apocynin inhibits the activation of STAT1 and NF-kappaB pathways in P+M-treated mice."

30798073

Apigenin affects IKBKB

1 | 2

Apigenin inhibits IKBKB. 3 / 3

1 | 2

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➶

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"Additionally, apigenin (30 mg/kg) administration suppressed pancreatic cancer growth and IKK-beta activation in nude mice xenograft."

24148603

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➶

reach

"However, in models of acute inflammation, apigenin reduces IKKbeta without affecting IKKalpha [XREF_BIBR]."

27338492

---

➶

ctd

No evidence text available

24148603

Anthra[1,9-cd]pyrazol-6(2H)-one affects RELA

| 3

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits RELA. 3 / 3

| 3

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➶

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"The subsequent application of JNK (SP600125), NFkappaB (PDTC), and serine protease (TPCK) inhibitors significantly inhibited the proliferation and IL-2 production of SP treated lymphocytes as well as the phosphorylation of JNK and IkappaB, the activation of nuclear NFkappaB p65, and binding of NFkappaB p65 DNA."

23262141

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➶

reach

"We found that SP600125 inhibited the translation of NF-kappaB p65 and cell inflammation and apoptosis induced by infection."

29681986

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➶

reach

"Twenty micromolar SP600125 and 10 muM SB203580 reduced the lipopolysaccharide caused increase in the NF-kappaB p65 to DNA binding activity in HaCaT cells."

29291542

Anthra[1,9-cd]pyrazol-6(2H)-one affects IRF3

| 1 2

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits IRF3. 3 / 3

| 1 2

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➶

medscan

"Interestingly, constitutive active IRF3(5D) can be inhibited by SP600125; JNK1 can synergize the action of IRF3(5D), but not the S173A-IRF3(5D) mutant."

19153595

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➶

reach

"Interestingly, constitutive active IRF3 (5D) can be inhibited by SP600125; JNK1 can synergize the action of IRF3 (5D), but not the S173A-IRF3 (5D) mutant."

19153595

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➶

reach

"The selective JNK inhibitor SP600125 also blocked IRF3 dimerization, suggesting that this function requires JNK (XREF_FIG)."

18713996

Amitriptyline affects CASP1

| 3

Amitriptyline inhibits CASP1. 3 / 3

| 3

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➶

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"Amitriptyline did not attenuate caspase-1 activation upon stimulation with NLRP3 activating LPS and ATP and LPS and nigericin treatments in mouse mixed glial cells (XREF_FIG)."

29016824

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➶

reach

"Antidepressant Amitriptyline Does Not Inhibit NLRP3 Dependent Caspase-1 Activation but Suppresses LPS Triggered IL-1beta mRNA Production."

29016824

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➶

reach

"Thus, we examined whether the antidepressant amitriptyline impairs NLRP3 dependent caspase-1 activation."

29016824

Alvocidib affects TYK2

3 |

Alvocidib inhibits TYK2. 3 / 3

3 |

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

22037378

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➶

tas

No evidence text available

18183025

All-trans-retinoic acid affects RELA

| 3

All-trans-retinoic acid inhibits RELA. 3 / 3

| 3

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➶

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"Indeed, ATRA caused a dose dependent decrease in abundance of Pin1 and its substrate oncogenes including cyclin D1 12, HER2 14, ERalpha 18 Akt 16, NFkappaB p65 13, c-Jun 11, and PKM2 19, as well as an increase in abundance of Pin1 substrate tumor suppressors such as Smad2/3 17 and SMRT 15 in all three ATRA sensitive cancer cell lines (XREF_FIG)."

25849135

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➶

reach

"Moreover, ATRA treatment increased the nucleus p65 and Tgase inhibitor CTM suppressed the p65 in nucleus (XREF_FIG B)."

24130925

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➶

reach

"ATRA also reduced nuclear levels of both subunits (p50 and p65) of NF-kappaB."

10432387

Agonist affects IRF3

| 3

Agonist inhibits IRF3. 3 / 3

| 3

---

➶

reach

"Results revealed that PLPro suppresses TLR7 agonist-induced production of type I IFNs through inhibiting the IRF-3 activation in the TLR7 signaling pathway."

27164085

---

➶

reach

"Results revealed that PLPro suppresses TLR7 agonist-induced production of type I IFNs through inhibiting the IRF-3 activation in the TLR7 signaling pathway.Besides type I IFN production, we checked whether the TLR7 agonist upregulates pro-inflammatory cytokines."

27164085

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➶

reach

"Molecular pathway analyses revealed that RO 90-7501 slightly suppressed poly I:C-induced NFkB activation, but did not apparently alter the TLR3 agonist-induced IRF3 nuclear translocation and IRF3 activated gene (ISG56) expression (data no shown)."

23056170

Adenosine affects CASP1

| 3

Adenosine inhibits CASP1. 3 / 3

| 3

---

➶

reach

"The PKA inhibitor KT5720 blocks activation of caspase-1 by adenosine."

24907587

---

➶

reach

"Inhibition of potassium efflux prevents adenosine dependent activation of caspase-1 in the brain."

24907587

---

➶

reach

"Peripheral administration of adenosine in wild-type (WT) mice led to a 2.3-fold increase in caspase-1 activity in the amygdala and to a 33% and 42% reduction in spontaneous locomotor activity and food intake, respectively, that were not observed in caspase-1 knockout (KO), IL-1 receptor type 1 (IL-1R1) KO and A2A AR KO mice or in mice administered a caspase-1 inhibitor centrally."

24907587

Acetylcholine affects STAT1

| 3

Acetylcholine inhibits STAT1. 3 / 3

| 3

---

➶

reach

"The mechanism by which Ach down-regulates pSTAT1 is related to an enhanced interaction between IFNalphaR2 and USP18 that finally dysregulates the cross talk between the IFN receptor on the cell surface and STAT1."

27716962

---

➶

reach

"Furthermore, Ach decreases ISGylation of STAT1 (protein conjugation of a small ubiquitin like modifier, ISG15, Western blot), which preserves STAT1 activation."

27716962

---

➶

reach

"In addition, Ach decreased accumulation of pSTAT1 in the nuclear fraction."

25217800

Acetoacetate affects NLRP3

| 3

Acetoacetate inhibits NLRP3. 3 / 3

| 3

---

➶

reach

"There is evidence that ketone bodies, beta-hydroxybutyrate (BHB), but not acetoacetate (AcAc) or the structurally related SCFAs, butyrate and acetate, suppress activation of the Nlrp3 inflammasome in response to urate crystals, ATP and lipotoxic fatty acids XREF_BIBR, XREF_BIBR."

29475132

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➶

reach

"We report that BHB, but neither acetoacetate nor structurally related short chain fatty acids, butyrate and acetate, suppresses activation of the NLRP3 inflammasome in response to several structurally unrelated NLRP3 activators, without impacting NLRC4, AIM2 or non canonical caspase-11 inflammasome activation."

25686106

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➶

reach

"A study by Youm et al. showed that the NLRP3 inflammasome activation was inhibited by the ketone body beta-hydroxybutyrate (BHB) but not by acetoacetate or by related short-chain fatty acids butyrate and acetate [XREF_BIBR]."

27942750

XL019 affects JAK1

1 | 2

XL019 inhibits JAK1. 3 / 3

1 | 2

---

➶

reach

"XL019 does not inhibit JAK1 (IC50 = 132 nM) or JAK3 (IC50 = 250 nM)."

22035745

---

➶

reach

"Most experience has been in patients with myelofibrosis in phase I/II trials employing INCB018424 (a potent and selective inhibitor of JAK1 and JAK2), TG101348 (a structure based drug designed to inhibit JAK2 with great selectivity), CEP-701 (a multikinase inhibitor), and XL019 (a selective JAK2 inhibitor whose clinical development has been halted because of neurotoxicity)."

20948870

---

➶

tas

No evidence text available

23127890

TUDCA affects NLRP3

| 3

TUDCA inhibits NLRP3. 3 / 3

| 3

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➶

reach

"Curcumin, as well as TUDCA, attenuated NLRP3 and cleaved caspase-1 expression (Figs. 6 A & B), and as expected, reduced IL-1beta secretion."

25791922

---

➶

reach

"Further, the ER stress TUDCA also suppressed NLRP3 activation in vitro, indicating that BHB is able to suppress NLRP3 inflammasome activation."

29662437

---

➶

reach

"TUDCA could attenuate the NLRP3 inflammasome activation not only in vitro but also in vivo."

23977286

TOZASERTIB LACTATE affects TYK2

3 |

TOZASERTIB LACTATE inhibits TYK2. 3 / 3

3 |

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➶

tas

No evidence text available

---

➶

tas

No evidence text available

18183025

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➶

tas

No evidence text available

22037378

TOZASERTIB LACTATE affects RIPK1

3 |

TOZASERTIB LACTATE inhibits RIPK1. 3 / 3

3 |

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➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

29437386

Sunitinib affects TBK1

3 |

Sunitinib inhibits TBK1. 3 / 3

3 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

Sunitinib affects RIPK1

3 |

Sunitinib inhibits RIPK1. 3 / 3

3 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

Sunitinib affects CHUK

3 |

Sunitinib inhibits CHUK. 3 / 3

3 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

22037378

Ser-Val affects IFNB1

| 3

Ser-Val inhibits IFNB1. 3 / 3

| 3

---

➶

reach

"In parallel, SV induced IFN-beta protein production was strikingly decreased when UBXN1 was overexpressed (XREF_FIG)."

23545497

---

➶

reach

"Furthermore, because of its robust inhibition of virus induced RIG-I multimerization and RIG-I-MAVS signaling complex formation, this SV effectively suppresses the RIG-I-mediated IFN-beta production."

18948594

---

➶

reach

"Furthermore, RIG-I SV suppresses the RIG-I-mediated IFN-beta production through inhibiting the formation of virus induced RIG-I multimerization and RIG-I-mitochondrial antiviral signaling protein (MAVS) signaling complex [XREF_BIBR]."

28714877

Ser-Met affects MYD88

| 3

Ser-Met inhibits MYD88. 3 / 3

| 3

---

➶

reach

"Post-hoc analyses showed that SM extract administration reduced the increase of MyD88 caused by BCCAo."

26597908

---

➶

reach

"The present study showed that SM extract inhibited the up-regulation of hippocampal TLR4 and MyD88 post-BCCAo."

26597908

---

➶

reach

"As SM inhibits the dissociation of MyD88 from the receptor without affecting TRIF recruitment, whereas dynasore inhibits TRIF recruitment without affecting MyD88 recruitment, it appears that each adaptor is independently recruited to TLR4."

19898473

SUNITINIB MALATE affects TBK1

3 |

SUNITINIB MALATE inhibits TBK1. 3 / 3

3 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

19654408

SUNITINIB MALATE affects RIPK1

3 |

SUNITINIB MALATE inhibits RIPK1. 3 / 3

3 |

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

SUNITINIB MALATE affects CHUK

3 |

SUNITINIB MALATE inhibits CHUK. 3 / 3

3 |

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

SB-242235 affects MAPK14

3 |

SB-242235 inhibits MAPK14. 3 / 3

3 |

---

➶

tas

No evidence text available

15012994

---

➶

tas

No evidence text available

18602262

---

➶

tas

No evidence text available

11597418

SB-210313 affects MAPK14

3 |

SB-210313 inhibits MAPK14. 3 / 3

3 |

---

➶

tas

No evidence text available

11354358

---

➶

tas

No evidence text available

9873686

---

➶

tas

No evidence text available

8831759

PRALNACASAN affects CASP1

3 |

PRALNACASAN inhibits CASP1. 3 / 3

3 |

---

➶

tas

No evidence text available

16046125

---

➶

tas

No evidence text available

16782334

---

➶

tas

No evidence text available

16870441

PCID:5353940 affects MAPK14

| 3

PCID:5353940 inhibits MAPK14. 3 / 3

| 3

---

➶

sparser

"Moreover, the pyridinyl-imidazole compounds SB 203580 and SB 202190 inhibit SAPK2a and SAPK2b, but not SAPK3 and SAPK4 ."

9199504

---

➶

sparser

"P38α and p38β are inhibited by SB 203580 and SB 202190, with IC 50 s of 0.092 μM and 1 μM, respectively."

10454214

---

➶

sparser

"Unlike SAPK1 (also called JNK), SAPK3 and SAPK4 did not phosphorylate the activation domain of c-Jun. Unlike SAPK2a and SAPK2b, SAPK4 and SAPK3 were not inhibited by the drugs SB 203580 and SB 202190."

9218798

Oclacitinib affects TYK2

2 | 1

Oclacitinib inhibits TYK2. 3 / 3

2 | 1

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➶

tas

No evidence text available

---

➶

tas

No evidence text available

---

➶

reach

"Oclacitinib inhibited JAK1, JAK2, JAK3, and TYK2 by 50% at concentrations (IC 50 's) of 10, 18, 99, and 84nm, respectively."

24495176

NS-5 affects STAT2

| 3

NS-5 inhibits STAT2. 3 / 3

| 3

---

➶

eidos

"Finally , NS5 mediates the degradation of STAT2 using the proteasome machinery ."

25629430

---

➶

eidos

"Finally , NS5 degrades STAT2 through a proteosoma-dependent mechanism , binding to the cellular protein ubiquitin protein ligase E3 component recognin 4 ( UBR4 ) ."

25629430

---

➶

eidos

"Although UBR4 does not belong to the TRIM family , it is possible that TRIM members may also be involved in STAT2 degradation by NS5 ."

28829373

NAC affects STAT1

| 3

NAC inhibits STAT1. 3 / 3

| 3

---

➶

reach

"Interestingly, even in the stimulated condition, NAC treatment reduced the ratio of phospho-STAT1 and total STAT1 in NNS patient derived MT-MLs (XREF_FIG B)."

29731430

---

➶

reach

"Alternatively, NAC may directly inhibit pSTAT-1 and T-bet activation independent of IFN-gamma."

22701598

---

➶

reach

"In a similar fashion, V 2 O 5 -stimulated STAT1 signaling is also attenuated by catalase or NAC."

19994902

NAC affects RIPK1

| 1 2

NAC inhibits RIPK1. 3 / 3

| 1 2

---

➶

sparser

"NAC (ROS inhibitor) inhibited RIP1, RIP3, and increased ATF4; however, necrostatin-1 (Nec-1) (RIP1 inhibitor) specifically inhibited the protein expression of RIP1 and RIP3 and had no influence on ATF4."

31090954

---

➶

reach

"In our study, NAC and AAP inactivated RIPK1 and RIPK3 that led to the reduction of H 2 O 2 -induced necroptosis (XREF_FIG)."

25909282

---

➶

reach

"In TCMK-1 cells, Klotho and NAC attenuated the elevation in RIP1, RIP3, and LDH release induced by H/R or H2O2."

29550818

NAC affects PYCARD

| 3

NAC inhibits PYCARD. 3 / 3

| 3

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➶

reach

"NAC significantly abrogated PrP106-126-induced NALP3 and ASC upregulation; the mRNA levels of NALP3 and ASC significantly decreased after NAC treatment in PrP106-126-treated microglia and dropped to 68% and 54%, respectively, of the levels seen in microglia treated with PrP106-126 only."

22531291

---

➶

reach

"In the present study, we found that the ROS inhibitor NAC significantly reduced the production of IL-1beta, and blocked NALP3 and ASC upregulation after exposure to PrP106-126, suggesting a role of ROS generation in the activation of the inflammasome in PrP106-126-stimulated microglia."

22531291

---

➶

reach

"Moreover, the ROS scavenger NAC inhibited NLRP3 inflammasome activation, indicated by the decreased expression of NLRP3 (XREF_FIG), ASC (XREF_FIG), and procaspase-1 (XREF_FIG) induced by HG and H/R (XREF_FIG)."

29062465

N-cyclopropyl-3-\{4-[(cyclopropylmethyl)carbamoyl]phenyl\}-4-methylbenzamide affects MAPK14

3 |

N-cyclopropyl-3-\{4-[(cyclopropylmethyl)carbamoyl]phenyl\}-4-methylbenzamide inhibits MAPK14. 3 / 3

3 |

---

➶

tas

No evidence text available

18614366

---

➶

tas

No evidence text available

19772287

---

➶

tas

No evidence text available

18602262

N-acetyl-L-cysteine affects RELA

2 | 1

N-acetyl-L-cysteine inhibits RELA. 3 / 3

2 | 1

---

➶

medscan

"Salusin-β-induced ACAT-1 and VCAM-1 expressions, and p65-NFκB nuclear translocation in Vascular smooth muscle cells were prevented by the treatment with a ROS scavenger N-acetyl-cysteine , a NADPH oxidase inhibitor apocynin or knockdown of NOX2 with siRNA ( )."

27004848

---

➶

ctd

No evidence text available

10661865

---

➶

ctd

No evidence text available

19176594

N-acetyl-L-cysteine affects MAPK8

| 3

N-acetyl-L-cysteine inhibits MAPK8. 3 / 3

| 3

---

➶

medscan

"Moreover, data of Western blot analysis (Fig. B and C) demonstrate that N-Acetyl Cysteine largely inhibits imiquimod-induced phosphorylation of ASK1, JNK and p38 in BLM cells."

26578344

---

➶

medscan

"In addition, N-acetylcysteine prevented lipopolysaccharide-induced activation of p38 MAPK and JNK but not phosphorylation and subsequent degradation of IkB."

18038907

---

➶

medscan

"N-acetyl-l-cysteine (NAC) inhibited the activation of JNK and p38-MAPK."

24402682

N-acetyl-L-cysteine affects FOS

2 | 1

N-acetyl-L-cysteine inhibits FOS. 3 / 3

2 | 1

---

➶

medscan

"Serum starvation (0.5% FBS) producing reactive oxygen species and the exogenous H(2)O(2) treatment also enhanced hBAFF promoter activity. c-Fos expression and AP-1 binding to oligonucleotide were reduced by the treatment with N-acetyl-cysteine."

22537850

---

➶

ctd

No evidence text available

14623829

---

➶

ctd

No evidence text available

17696279

N-acetyl-L-cysteine affects CASP1

| 3

N-acetyl-L-cysteine inhibits CASP1. 3 / 3

| 3

---

➶

reach

"Equally, administration of n-acetylcysteine to fasted WT mice prevented HFD dependent learning impairment and caspase-1 activation in the BLp."

31697963

---

➶

reach

"N-acetylcysteine treatment at 0 and 24 hours after hypoxia-ischemia in lipopolysaccharide -exposed 8-day-old rats dramatically improved pathology scores and decreased caspase 1 and 3 compared with saline controls, while N-acetylcysteine delayed until 2 hours and 24 hours after hypoxia-ischemia had no beneficial effect."

19745093

---

➶

reach

"The antioxydant N-acetylcysteine can inhibit both ATPmediated caspase-1 activation and, interestingly, NLRP3 inflammation activation due to treatment with ionophores such as nigericin."

20011701

N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide affects TYK2

3 |

N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide inhibits TYK2. 3 / 3

3 |

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide affects IRF3

| 3

N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide inhibits IRF3. 3 / 3

| 3

---

➶

reach

"First, we pretreated MDMs with BX795, which potently blocks IRF3 activation and interferon production through inhibition of the IKK related kinases TANK binding kinase 1 and IKKepsilon."

29780383

---

➶

reach

"BX795, an inhibitor of TBK1 and IKKepsilon, inhibited the activation of IRF3 (XREF_FIG, 4 th lane), and restored the inhibition of TGF-beta-induced transcription by TpIC (XREF_FIG, lanes 3, 4)."

25526531

---

➶

reach

"Inhibition of IRF3 activation by BX795 in HepG2 and C3A cells prevented synthesis of interferon stimulated genes and improved HEV replication in these cells."

27230536

Met-Phe affects NLRP3

| 3

Met-Phe inhibits NLRP3. 3 / 3

| 3

---

➶

reach

"Recently, He et al. observed that MF inhibited the activation of the NLRP3 inflammasome, which contributed to the nephroprotective effect of MF against sepsis induced acute kidney injury along with its upregulation of Nrf2 15."

28928429

---

➶

reach

"In addition, MF downregulated the activation of the NLRP3 inflammasome and NF-kappaB as well as the production of inflammatory cytokines, and the expression of Nrf2 and HO-1 was upregulated by MF."

28928429

---

➶

reach

"Moreover, MF reduced neuroinflammation, inhibited gliosis, and attenuated the activation of P2X7 receptor, TLR4 and MyD88, NLRP3, and NF-kappaB."

31766248

Mesalazine affects IKBKB

3 |

Mesalazine inhibits IKBKB. 3 / 3

3 |

---

➶

drugbank

No evidence text available

11054378

---

➶

drugbank

No evidence text available

12950415

---

➶

drugbank

No evidence text available

11151876

Mesalazine affects CHUK

3 |

Mesalazine inhibits CHUK. 3 / 3

3 |

---

➶

drugbank

No evidence text available

11054378

---

➶

drugbank

No evidence text available

11151876

---

➶

drugbank

No evidence text available

12950415

LY294002 affects MAPK8

1 | 1 1

LY294002 inhibits MAPK8. 3 / 3

1 | 1 1

---

➶

medscan

"Using HER2-positve gastric cancer cell lines SNU-216 and NCI-N87, HER2 expression was silenced by RNA interference, and the activations of JNK and AKT were suppressed by SP600125 and LY294002, respectively."

27895401

---

➶

ctd

No evidence text available

16442704

---

➶

reach

"Notably, neither wortmannin nor LY294002 directly inhibited basal JNK1 activity (data not shown)."

10206340

LY294002 affects JUN

| 2 1

LY294002 inhibits JUN. 3 / 3

| 2 1

---

➶

medscan

"HGF-mediated AP-1-luciferase activity and c-Jun binding to the AP-1 element was reduced by c-Met inhibitor, Ly294002, Akt inhibitor, and PP2."

22675553

---

➶

medscan

"Peptidoglycan mediated an increase in the accumulation of phosphorylated c-Jun in the nucleus, AP-1-luciferase activity, and c-Jun binding to AP-1 element was inhibited by Ly294002, Akt inhibitor, and FAK mutant."

19635908

---

➶

reach

"Interestingly, the addition of LY294002, SP600125 and PD98059 prevented the fibroin stimulation of c-Jun (XREF_FIG)."

22860103

LSM-1221 affects TYK2

3 |

LSM-1221 inhibits TYK2. 3 / 3

3 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

18183025

LSM-1221 affects JAK1

3 |

LSM-1221 inhibits JAK1. 3 / 3

3 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

LSM-1221 affects IKBKE

3 |

LSM-1221 inhibits IKBKE. 3 / 3

3 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

LPS with O-antigen affects RELA

| 3

LPS with O-antigen inhibits RELA. 3 / 3

| 3

---

➶

reach

"Lipopolysaccharide exposure mimics and voluntary exercise prevents AIE induced upregulation of pNF-kappaB p65 in the young adult DRN."

27647531

---

➶

reach

"On the other hand, KA did not affect the degradation of cytoplasmic IkappaB-alpha, the nuclear localization of RelA (p65), and NF-kappaB transcriptional activity in RAW 264.7 cells treated with endotoxin."

21884778

---

➶

reach

"Farrerol Relieve Lipopolysaccharide (LPS)-Induced Mastitis by Inhibiting AKT and NF-kappaB p65, ERK1/2 and P38 Signaling Pathway."

29904013

L-ascorbic acid affects NFKBIA

| 3

L-ascorbic acid inhibits NFKBIA. 3 / 3

| 3

---

➶

reach

"As shown in Fig. 7 D, vitamin C partially inhibited the TNF-alpha-induced activation of IKKbeta and IkappaBalpha."

29625084

---

➶

reach

"Several studies have also shown that vitamin C inhibited the activation of the IkappaBalpha and NF-kappaB pathway in primary HUVECs, protecting against immunological hepatic injury in mice (Bowie and O'Neill, 2000; Carcamo et al., 2002; Liang et al., 2014)."

29625084

---

➶

reach

"Similarly, the present data revealed that vitamin C inhibited the TNF-alpha-triggered activation of IKKbeta, IkappaBalpha, NF-kappaB, JNK and p38 (although without a significant inhibitory effect on ERK activation) in HepG2 cells, and inhibited the NF-kappaB activation and the expression of IL-6 and IL-1alpha in liver tissues of Gulo -/- mice."

29625084

L-ascorbic acid affects IKBKB

| 3

L-ascorbic acid inhibits IKBKB. 3 / 3

| 3

---

➶

reach

"Similarly, the present data revealed that vitamin C inhibited the TNF-alpha-triggered activation of IKKbeta, IkappaBalpha, NF-kappaB, JNK and p38 (although without a significant inhibitory effect on ERK activation) in HepG2 cells, and inhibited the NF-kappaB activation and the expression of IL-6 and IL-1alpha in liver tissues of Gulo -/- mice."

29625084

---

➶

reach

"As shown in Fig. 7 D, vitamin C partially inhibited the TNF-alpha-induced activation of IKKbeta and IkappaBalpha."

29625084

---

➶

reach

"Moreover, after oxidation to dehydroascorbic acid, vitamin C has been shown to directly inhibit IKKalpha, IKKbeta, and p38 MAPK activity."

23675368

JQ1 affects RELA

| 2 1

JQ1 inhibits RELA. 3 / 3

| 2 1

---

➶

medscan

"Since JQ1 blocks the interaction between RelA and Brd4 and inhibits transcription activity of NF-κB ( ), we next determined whether JQ1 might have a similar effect as knockdown of Brd4."

23686307

---

➶

reach

"Consistently, JQ1 induced the degradation of RelA, which was prevented by treatment with proteasome inhibitor MG-132 (XREF_FIG)."

23686307

---

➶

medscan

"Notably, the interaction was inhibited by the addition of JQ1 ( ), suggesting that JQ1 inhibits the binding of acetylated lysine-310 RelA peptides to the bromodomains of Brd4."

23686307

Interferon alfacon-1 affects IFNAR2

3 |

Interferon alfacon-1 inhibits IFNAR2. 3 / 3

3 |

---

➶

drugbank

No evidence text available

8836913

---

➶

drugbank

No evidence text available

12528473

---

➶

drugbank

No evidence text available

11752352

Inhibitor of P38 Kinase affects MAPK14

3 |

Inhibitor of P38 Kinase inhibits MAPK14. 3 / 3

3 |

---

➶

drugbank

No evidence text available

17016423

---

➶

drugbank

No evidence text available

17139284

---

➶

drugbank

No evidence text available

10592235

Heparin affects JUN

| 3

Heparin inhibits JUN. 3 / 3

| 3

---

➶

reach

"Heparin suppresses PMA induced expression of c-jun and Jun B mRNA and protein in baboon VSMC [XREF_BIBR]."

16945153

---

➶

reach

"Heparin suppresses PMA induced expression of c-jun and Jun B mRNA and protein in baboon VSMC [XREF_BIBR]."

16945153

---

➶

reach

"Heparin inhibits activator protein-1, which is the nuclear target of many oncogenic signal transduction pathways, and it potently inhibits casein kinase II, which has carcinogenic activity."

10023691

Filgotinib affects TYK2

3 |

Filgotinib inhibits TYK2. 3 / 3

3 |

---

➶

tas

No evidence text available

26351728

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

24417533

FLAVOPYRIDOL affects TYK2

3 |

FLAVOPYRIDOL inhibits TYK2. 3 / 3

3 |

---

➶

tas

No evidence text available

22037378

---

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No evidence text available

18183025

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➶

tas

No evidence text available

FILGOTINIB affects TYK2

3 |

FILGOTINIB inhibits TYK2. 3 / 3

3 |

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tas

No evidence text available

24417533

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➶

tas

No evidence text available

26351728

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➶

tas

No evidence text available

FILGOTINIB HYDROCHLORIDE affects TYK2

3 |

FILGOTINIB HYDROCHLORIDE inhibits TYK2. 3 / 3

3 |

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tas

No evidence text available

26351728

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➶

tas

No evidence text available

---

➶

tas

No evidence text available

24417533

EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor affects MYD88

| 3

EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor inhibits MYD88. 3 / 3

| 3

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➶

reach

"In addition, association of B. burgdorferi with actin related protein (Arp2/3) complexes, which facilitate actin rearrangements during phagocytosis, was similarly reduced in MyD88 -/- BMDMs and BMDMs treated with a PI3K inhibitor."

19542460

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➶

reach

"Additionally, association of B. burgdorferi with actin related protein (Arp2/3) complexes, which facilitate actin rearrangements during phagocytosis, was similarly reduced in MyD88 (-/-) BMDMs and in BMDMs treated with a PI3K inhibitor."

19542460

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➶

reach

"We show that both MyD88 -/- BMDMs and WT BMDMs treated with a PI3K inhibitor failed to recruit Arp3 to sites of B. burgdorferi, suggesting a potential role of MyD88 and PI3K for initiating actin polymerization (XREF_FIG)."

19542460

DOVITINIB affects TYK2

3 |

DOVITINIB inhibits TYK2. 3 / 3

3 |

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No evidence text available

18183025

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➶

tas

No evidence text available

---

➶

tas

No evidence text available

22037378

DOVITINIB affects IKBKE

3 |

DOVITINIB inhibits IKBKE. 3 / 3

3 |

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tas

No evidence text available

---

➶

tas

No evidence text available

18183025

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➶

tas

No evidence text available

22037378

D-cycloserine affects NFKBIA

| 1 2

D-cycloserine inhibits NFKBIA. 3 / 3

| 1 2

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reach

"As shown in Figure XREF_FIG A, B and C, DCS inhibited NF-kappaB activation by blocking IkappaBalpha degradation."

28444871

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➶

reach

"Furthermore, it was observed that high magnitude of DCS alone could induce IkappaB-alpha degradation compared to low magnitude that maintains the protein level similar to untreated control."

19370157

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➶

eidos

"DCS decreased the expressions of IKBa and the phosphorylation of NF-jB ."

28444871

Carnosol affects CASP1

| 3

Carnosol inhibits CASP1. 3 / 3

| 3

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reach

"We evaluated whether carnosol treatment could prevent NLRC4 inflammasome activation, and our results showed that carnosol treatment disrupted NLRC4 dependent caspase-1 activation as well as IL-1beta secretion in Salmonella infected LPS primed BMDMs, whereas TNF-alpha production remained unchanged."

32312957

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➶

reach

"We observed that carnosol treatment disrupted caspase-1 cleavage and IL-1beta maturation, which were triggered by these NLRP3 inflammasome stimuli."

32312957

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➶

reach

"Our results showed that carnosol inhibited caspase-1 and IL-1beta production in a dose dependent manner, as well as the release of LDH in LPS primed BMDMs."

32312957

CCCP affects CASP1

| 3

CCCP inhibits CASP1. 3 / 3

| 3

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reach

"Addition of CCCP 15 min after infection blocked macrophage cell death, the activation of caspase-1 and the maturation of IL-1beta, without affecting uptake or escape of S. flexneri from the phagosome."

17768231

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➶

reach

"Consistently, CCCP abolished LPS and nigericin triggered caspase-1 activation in NLRP3-stably expressing macrophages (XREF_FIG), demonstrating that CCCP mediated inhibition of NLRP3 inflammasome is not resulted from the reduced NLRP3 expression."

26489382

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➶

reach

"However, CCCP induced inhibition of caspase-1 activation by LPS and ATP was also evident in Atg5 -/- BMDMs (XREF_FIG)."

26489382

Aminosalicylic acid affects CHUK

3 |

Aminosalicylic acid inhibits CHUK. 3 / 3

3 |

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drugbank

No evidence text available

11054378

---

➶

drugbank

No evidence text available

12950415

---

➶

drugbank

No evidence text available

11151876

Ala-Pro affects FOS

| 3

Ala-Pro inhibits FOS. 3 / 3

| 3

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reach

"In support of this possibility, it has been shown that AP ablation blocks the increase of c-Fos in DMX and NTS induced by peripheral administration of ghrelin."

24888783

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➶

reach

"Therefore, we predicted that AP lesions would block some, but not all, of the c-Fos responses to LiCl."

21889521

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➶

reach

"While these data suggest that AP ablation blocked the c-Fos induction by LiCl seen in the sham rats, it is important to keep in mind that this effect could be the result of direct damage to the NTS rather than the loss of input from the AP."

21889521

ATP affects TRAF3

| 3

ATP inhibits TRAF3. 3 / 3

| 3

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➶

reach

"ATP inhibition of cRaf-1 activation was not mediated by an increase in cyclic AMP levels or by protein kinase C activation."

11359865

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➶

reach

"ATP also inhibited the activation of cRaf-1 by other growth factors, epidermal growth factor and platelet derived growth factor, as well as other MEK1 activators stimulated by FGF-2, MEK kinase 1 (MEKK1) and MEKK2."

11359865

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➶

reach

"Surprisingly, ATP inhibited activation of cRaf-1 by FGF-2 in primary cultures of rat cortical astrocytes."

11359865

ATP affects NFKBIA

| 3

ATP inhibits NFKBIA. 3 / 3

| 3

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reach

"ATP has no effect on the binding of an IkappaBalpha peptide for the rhIKK-1 and rhIKK-2 heterodimer (alpha = 0.99), whereas the binding of ATP decreased the affinity of the IkappaBalpha peptide for both rhTBK-1 (alpha = 10.16) and rhIKK-i (alpha = 62.28)."

11815618

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reach

"19 Given the essential role of ATP dependent proteosomal degradation of IkappaBalpha, XREF_BIBR, XREF_BIBR - XREF_BIBR we propose that the protective effect of epoxomicin on importins turnover in stimulated cells implies a similar mechanism of proteosomal degradation."

24042087

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reach

"16 When inflammatory signaling is induced, IkappaBalpha is rapidly degraded by proteasomes in an ATP dependent manner."

24042087

ATP affects DDX58

| 1 2

ATP inhibits DDX58. 3 / 3

| 1 2

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reach

"Mutation of the RIG-I ATP binding site abolishes RIG-I activity, suggesting that ATP and RNA dependent conformational changes are essential for sensing viral RNA XREF_BIBR."

19115016

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➶

reach

"It was reported that RIG-I ATP hydrolysis increases the binding affinity of RIG-I and dsRNA ligands; whereas the RIG-I mutants deficient in ATP hydrolysis promotes the interaction of RIG-I and self-dsRNA and results in unintentional immune signaling (47)."

28096803

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➶

medscan

"ATP hydrolysis displaces wild-type RIG-I from this self-RNA but not from 5' triphosphate dsRNA."

26609812

AST-487 affects MAPK8

3 |

AST-487 inhibits MAPK8. 3 / 3

3 |

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tas

No evidence text available

18183025

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

22037378

AST-487 affects MAPK14

3 |

AST-487 inhibits MAPK14. 3 / 3

3 |

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➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

APP affects NFKBIA

| 3

APP inhibits NFKBIA. 3 / 3

| 3

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➶

reach

"Importantly, NBP markedly suppressed Abeta induced IkappaBalpha degradation and nuclear factor-kappaB (NF-kappaB) translocation."

23899885

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➶

reach

"Herein, we assessed the impact of taxifolin on the Abeta stimulated degradation of IkappaBalpha in cytosol and on the nuclear translocation of NF-kappaB p65."

27977755

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➶

reach

"Herein, we assessed the impact of taxifolin on the Abeta stimulated degradation of IkappaBalpha in cytosol and on the nuclear translocation of NF-kappaB."

27977755

AM-251 affects RELA

| 1 2

AM-251 inhibits RELA. 3 / 3

| 1 2

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reach

"Further, application of AM251 led to decrease of constitutively active NFkappaB and p65, a crucial survival factor of HRS-cells, and was followed by elevation of apoptotic markers in HL cells."

24349109

---

➶

reach

"AM251 reduces p65, diminishes cells in S-phase and induces apoptosis in L428 cells."

24349109

---

➶

medscan

"Further, application of AM251 led to decrease of constitutively active NFκB/p65, a crucial survival factor of HRS-cells, and was followed by elevation of apoptotic markers in Hodgkin lymphoma cells."

24349109

AICA ribonucleotide affects NLRP3

| 3

AICA ribonucleotide inhibits NLRP3. 3 / 3

| 3

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➶

reach

"Salicylate and AICAR reduced NLRP3 and cleaved caspase-1 expression, and then decreased IL-1beta production."

26196303

---

➶

reach

"AICAR and salicylate inhibited NLRP3 induction and caspase-1 activation, and as a result, IL-1beta secretion was reduced."

26196303

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➶

reach

"AMPKalpha activator AICAR (5-aminoimidazole-4-carbox-amide-1-beta-d-ribofuranoside) inhibited NLRP3 inflammasome activation and decreased IL-1beta release and restored impaired insulin signal pathway induced by palmitate."

31705915

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one affects MAPK8

3 |

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one inhibits MAPK8. 3 / 3

3 |

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tas

No evidence text available

22037378

---

➶

tas

No evidence text available

22257213

---

➶

tas

No evidence text available

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one affects CASP1

| 3

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one inhibits CASP1. 3 / 3

| 3

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➶

reach

"Furthermore, R406 inhibited caspase-1 activity after CaP particle exposure, as assessed by quantitative live cell imaging (XREF_FIG D), with no effect on VSMC death (Supplement Fig."

29274344

---

➶

reach

"On the other hand, LFM-A13 and R406 suppressed IL-1beta secretion and caspase-1 activation without affecting pro-IL-1beta accumulation in THP-1-Mphi (XREF_FIG)."

26059659

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➶

reach

"The SYK inhibitor R406 reduced IL-1beta release and caspase-1 activation in CaP particle treated VSMCs, indicating that SYK activation occurs upstream of and is required for caspase-1 activation."

29274344

5-(5,6-dimethoxy-1-benzimidazolyl)-3-[(2-methylsulfonylphenyl)methoxy]-2-thiophenecarbonitrile affects IKBKE

3 |

5-(5,6-dimethoxy-1-benzimidazolyl)-3-[(2-methylsulfonylphenyl)methoxy]-2-thiophenecarbonitrile inhibits IKBKE. 3 / 3

3 |

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tas

No evidence text available

16997559

---

➶

tas

No evidence text available

17502144

---

➶

tas

No evidence text available

24462666

4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone affects TYK2

3 |

4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone inhibits TYK2. 3 / 3

3 |

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➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone affects IKBKE

3 |

4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone inhibits IKBKE. 3 / 3

3 |

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➶

tas

No evidence text available

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide affects JAK1

3 |

4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide inhibits JAK1. 3 / 3

3 |

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tas

No evidence text available

21106455

---

➶

tas

No evidence text available

28626521

---

➶

tas

No evidence text available

18183025

4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline affects MAPK14

3 |

4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline inhibits MAPK14. 3 / 3

3 |

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➶

drugbank

No evidence text available

17139284

---

➶

drugbank

No evidence text available

17016423

---

➶

drugbank

No evidence text available

10592235

4-(ethoxymethylene)-2-phenyloxazol-5-one affects NFKBIA

| 3

4-(ethoxymethylene)-2-phenyloxazol-5-one inhibits NFKBIA. 3 / 3

| 3

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➶

reach

"SHXT treatment increased cell viability and mitochondria membrane potential (MMP), decreased expression of nNOS, COX-2, gp91 phox and iROS, and inhibited IkappaBalpha degradation in 6-OHDA-treated SH-SY5Y cells."

19339484

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➶

reach

"In addition, it was reported that PHOX inhibitors prevented LPS and IFNgamma induced degradation of IkappaBalpha, and thus, inhibited the activation of NF-kappaB."

18566433

---

➶

reach

"In addition, it has been reported that PHOX inhibitors prevent LPS and IFNgamma induced degradation of IkappaBalpha, and thus inhibit activation of NF-kappaB [XREF_BIBR]."

18507839

4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[(5-nitro-2-thiazolyl)thio]-1H-1,2,4-triazol-5-one affects MAPK8

1 2 |

4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[(5-nitro-2-thiazolyl)thio]-1H-1,2,4-triazol-5-one inhibits MAPK8. 3 / 3

1 2 |

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➶

tas

No evidence text available

20045647

---

➶

signor

"Bi-78d3, dose-dependently inhibits the phosphorylation of jnk substrates both in vitro and in cell."

18922779

---

➶

tas

No evidence text available

20146479

3-(trimethylsilyl)propane-1-sulfonic acid affects RELA

| 3

3-(trimethylsilyl)propane-1-sulfonic acid inhibits RELA. 3 / 3

| 3

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➶

reach

"Although we failed to notice any significant difference in total NF-kappaBp65 in Caco-2 cells (P> 0.05), DSS treatment markedly enhanced nuclear NF-kappaBp65 abundance and genistein reduced nuclear NF-kappaBp65 compared with the DSS group (P < 0.05)."

28977871

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➶

reach

"DSS induced colitis is attenuated in RelA and p65 Deltamye mice."

23562811

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➶

reach

"DSS induced colitis is attenuated in RelA and p65 Deltamye mice."

23562811

3-(trimethylsilyl)propane-1-sulfonic acid affects CHUK

| 3

3-(trimethylsilyl)propane-1-sulfonic acid inhibits CHUK. 3 / 3

| 3

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➶

reach

"In addition, the DSS induced phospho-IkappaB kinase activation was significantly decreased in fexofenadine pretreated mice."

25538104

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➶

reach

"In addition, the DSS induced phospho-IkappaB kinase activation was significantly decreased in roxithromycin pretreated mice."

26088864

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➶

reach

"When cells were coincubated with DSS and Tempol, the DSS induced effects were inhibited in the WT and the IKKalpha -/- cells."

19085995

3-(Benzyloxy)Pyridin-2-Amine affects MAPK14

3 |

3-(Benzyloxy)Pyridin-2-Amine inhibits MAPK14. 3 / 3

3 |

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➶

drugbank

No evidence text available

17016423

---

➶

drugbank

No evidence text available

10592235

---

➶

drugbank

No evidence text available

17139284

3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine affects MAPK14

3 |

3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine inhibits MAPK14. 3 / 3

3 |

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➶

drugbank

No evidence text available

10592235

---

➶

drugbank

No evidence text available

17139284

---

➶

drugbank

No evidence text available

17016423

24,25-Dihydroxyvitamin D affects RELA

| 3

24,25-Dihydroxyvitamin D inhibits RELA. 3 / 3

| 3

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➶

reach

"Various groups have shown that the nuclear factor kappa-B (NFkappaB) family is linked to the VDR signaling pathway, and that Vitamin D inhibits monocyte NFkappaB p65 activation with down-stream suppression of various pro inflammatory cytokines including TNF-alpha, IL-1, and IL-6 [XREF_BIBR]."

21629196

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➶

reach

"Various groups have shown that the transcription factor NFkappaB family is linked to the vitamin D receptor (VDR) signalling pathway [XREF_BIBR - XREF_BIBR], and that vitamin D inhibits monocyte NFkappaB p65 activation with down stream suppression of various pro inflammatory cytokines including Tumour Necrosis Factor alpha (TNFalpha), Interleukin (IL)-1beta, and IL-6 [XREF_BIBR]."

20003316

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➶

reach

"In summary, we found GC induced increase in the levels of both NF-kappaB phosphorylated and non phosphorylated p65 subunits in BM cells and demonstrated that vitamin D 3 administration attenuated transcriptional activation of the NF-kappaB p65."

29930537

24,25-Dihydroxyvitamin D affects NFKB1

| 3

24,25-Dihydroxyvitamin D inhibits NFKB1. 3 / 3

| 3

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➶

reach

"Vitamin D suppresses DC differentiation and maturation by downregulating NF-Kb through transcription control of relb gene."

29093710

---

➶

reach

"XREF_BIBR - XREF_BIBR In Jurkat cells with constitutive expression of VDR, no inhibition of NFKB by vitamin D was observed, XREF_BIBR suggesting that some tumor cells have inactivated this pathway."

24665206

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➶

reach

"XREF_BIBR Vitamin D can probably activate the NFKB pathway, XREF_BIBR, XREF_BIBR but in most systems, vitamin D inhibits NFKB activation."

24665206

2-thiouridine affects TLR7

| 1 2

2-thiouridine inhibits TLR7. 3 / 3

| 1 2

---

➶

reach

"m6A, m5C, m5U, s2U, and Ψ modifications impeded stimulation of TLR7 and 8 (see Figure 1 for structures)."

30699960

---

➶

eidos

"of pseudouridine ( Psi ) , 5methylcytidine ( m5C ) , 2thio uridine ( s2U ) or N6methyladenosine ( m6A ) was found to potently inhibit TLR7 and TLR8 and to reduce TLR3 activity , which is the least sensitive receptor to RNA modifications 88 ."

27455396

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➶

reach

"m6A, m5C, m5U, s2U, and Psi modifications impeded stimulation of TLR7 and 8 (see XREF_FIG for structures)."

30699960

2-thiouridine affects DDX58

| 1 2

2-thiouridine inhibits DDX58. 3 / 3

| 1 2

---

➶

reach

"Incorporation of Psi, 5-methyluridine (m5U) or s2U was also found to abolish RIG-I activation 72."

27455396

---

➶

reach

"Incorporation of Ψ, 5-methyluridine (m5U) or s2U was also found to abolish RIG-I activation72."

27455396

---

➶

eidos

"Incorporation of Psi , 5-methyluridine ( m5U ) or s2U was also found to abolish RIG-I activation72 ."

27455396

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one affects STAT1

| 3

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one inhibits STAT1. 3 / 3

| 3

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➶

reach

"XREF_BIBR P6 suppressed the IFN-gamma and STAT1, IL-2 and STAT5, and IL-4 and STAT6 signaling pathways strongly while it suppressed IL-6 and STAT3 pathway only modestly, resulting in reduction of the Th1 and Th2 responses but the enhancement of the T17 response."

24069552

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➶

reach

"While p-STAT1 was considerably increased in both cell lines in the presence of cisplatin, P6 almost entirely suppressed p-STAT1 in both cell lines."

21945668

---

➶

reach

"We also demonstrated that BMDMs from STAT1 -/- mice and BMDMs from WT mice treated with JAK-I inhibitor failed to induce the expression of Dll1 following stimulation with PolyI : C, H1N1 or rIFN-beta (XREF_FIG E and F)."

22072963

2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione affects TBK1

| 2 1

2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione inhibits TBK1. 3 / 3

| 2 1

---

➶

sparser

"Therefore, it would be very interesting to explore the correlation of TBK1 inhibition by TQ and ER stress-mediated apoptosis which might be contributing to the anticancer activity of TQ."

29751576

---

➶

sparser

"In addition, based on our findings, the role of TBK1 inhibition by TQ with respect to the endoplasmic reticulum (ER) signaling pathway could be addressed in the future studies."

29751576

---

➶

reach

"Therefore, it would be very interesting to explore the correlation of TBK1 inhibition by TQ and ER stress mediated apoptosis which might be contributing to the anticancer activity of TQ."

29751576

2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]-3-azetidinyl]acetonitrile affects ITCH

| 3

2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]-3-azetidinyl]acetonitrile inhibits ITCH. 3 / 3

| 3

---

➶

reach

"Recent studies reported that baricitinib improved clinical signs and symptoms in patients with moderate-to-severe atopic dermatitis and induced rapid reduction of itch[32]."

| PMC

---

➶

reach

"Recent studies reported that baricitinib improved clinical signs and symptoms in patients with moderate-to-severe atopic dermatitis and induced rapid reduction of itch XREF_BIBR."

| PMC

---

➶

reach

"Baricitinib improved clinical signs and symptoms in patients with moderate-to-severe AD within 16 weeks of treatment and induced rapid reduction of itch."

31995838

2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione affects NFKB1

3 |

2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione inhibits NFKB1. 3 / 3

3 |

---

➶

ctd

No evidence text available

12242718

---

➶

ctd

No evidence text available

17164350

---

➶

ctd

No evidence text available

14713331

1H-imidazole affects MAPK14

| 3

1H-imidazole inhibits MAPK14. 3 / 3

| 3

---

➶

reach

"Therefore, we proceeded to determine if the pyridinyl imidazole derivative SB203580 could efficiently block the kinase activity of Mxi2."

10838079

---

➶

reach

"Binding of piridynyl- imidazole compounds inhibited CSBP kinase activity required for dissociation of 37-40 kDa regulatory protein which blocks translation of cytokine mRNA."

8950192

---

➶

reach

"SB203580, a pyridinyl imidazole which inhibits SAPK2a [34], has been widely used to implicate this signalling pathway in the phosphorylation of eIF4E [2,3,5,16,18-21,28]."

12781867

1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea affects MAPK14

3 |

1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea inhibits MAPK14. 3 / 3

3 |

---

➶

drugbank

No evidence text available

17016423

---

➶

drugbank

No evidence text available

10592235

---

➶

drugbank

No evidence text available

17139284

1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One affects MAPK14

3 |

1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One inhibits MAPK14. 3 / 3

3 |

---

➶

drugbank

No evidence text available

17139284

---

➶

drugbank

No evidence text available

10592235

---

➶

drugbank

No evidence text available

17016423

1,4-benzoquinone affects CASP1

1 | 2

1,4-benzoquinone inhibits CASP1. 3 / 3

1 | 2

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➶

ctd

No evidence text available

9118901

---

➶

reach

"Benzoquinone was also shown to completely inhibit the ability of the SH dependent IL-1 beta converting enzyme."

9118901

---

➶

reach

"P-Benzoquinone, a reactive metabolite of benzene, prevents the processing of pre-interleukins-1 alpha and -1 beta to active cytokines by inhibition of the processing enzymes, calpain, and interleukin-1 beta converting enzyme."

9118901

(S)-naringenin affects IFNB1

| 3

(S)-naringenin inhibits IFNB1. 3 / 3

| 3

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➶

reach

"Interestingly, we found that naringenin did not affect the activation of IRF3 or inhibit the production of IFN-beta and RANTES, which require IRF3 activation."

28004841

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➶

reach

"In our study, naringenin failed to inhibit the activation of IRF3 or attenuate the production of IFN-beta or RANTES."

28004841

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➶

reach

"However, naringenin did not inhibit IFN-beta and RANTES, which was consistent with cellular experiments and further indicate that the IRF3 pathway was also not affected in vivo."

28004841

(E)-3-tosylacrylonitrile affects NLRP3

| 3

(E)-3-tosylacrylonitrile inhibits NLRP3. 3 / 3

| 3

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➶

reach

"Interestingly, the IkappaB kinase-beta inhibitor Bay-11-7082 was found to potently inhibit the NLRP3 inflammasome, most likely through inhibiting the NLRP3 ATPase activity [XREF_BIBR]."

25204592

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➶

reach

"Our results indicated that BAY-11-7082 could inhibit NLRP3 inflammasome activation to inhibit caspase-1-dependent pyroptosis and the inflammatory response, thus alleviating MI/R injury in diabetic rats and H/R injury in HG condition H9C2 cells."

29062465

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➶

reach

"By inhibiting ERK and NF-κB, U0126 and BAY 117082 inhibited mir-21 over-expression-induced activation of the NLRP3 inflammasome complex."

29084974

(-)-epigallocatechin 3-gallate affects IRF3

| 3

(-)-epigallocatechin 3-gallate inhibits IRF3. 3 / 3

| 3

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➶

reach

"Youn and colleagues [XREF_BIBR] reported that EGCG could inhibit LPS- or PolyI : C mediated activation of interferon regulatory factor 3."

22768975

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➶

reach

"However, EGCG did not inhibit activation of IRF3 induced by overexpression of constitutively active IRF3."

16890209

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➶

reach

"Furthermore, EGCG has been reported to inhibit the activation of transcription factor, NF-kappaB (possibly through the suppression of IkappaB kinase) and IRF3 (via suppression of kinase activity of TBK1) XREF_BIBR - XREF_BIBR."

20877565

(+)-artemisinin affects NFKB1

| 3

(+)-artemisinin inhibits NFKB1. 3 / 3

| 3

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➶

reach

"To determine if one or more of these sites plays a role in conferring artemisinin responsiveness to the CDK4 promoter, chromatin immunoprecipitation was used to directly determine whether artemisinin disrupts the endogenous interactions of Sp1, AP-1, p50, and p65 with the CDK4 promoter."

24296733

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➶

reach

"Therefore, given the observed effects of artemisinin disrupting the binding of NF-kappaB subunits p65 and p50 to the CDK4 promoter, we investigated whether artemisinin disrupts NF-kappaB localization into the cell nuclei."

24296733

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➶

reach

"Our results provide direct evidence that artemisinin disrupts interactions of the p50 and p65 subunits of NF-kB with a critical cell cycle target gene promoter to mediate an anti-proliferative response in human endometrial cancer cells."

24296733

N-[(3Z)-5-Tert-butyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-ylidene]-N'-(4-chlorophenyl)urea affects MAPK14

3 |

N-[(3Z)-5-Tert-butyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-ylidene]-N'-(4-chlorophenyl)urea inhibits MAPK14. 3 / 3

3 |

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➶

drugbank

No evidence text available

10592235

---

➶

drugbank

No evidence text available

17139284

---

➶

drugbank

No evidence text available

17016423

N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide affects MAPK14

3 |

N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide inhibits MAPK14. 3 / 3

3 |

---

➶

tas

No evidence text available

18602262

---

➶

tas

No evidence text available

17981461

---

➶

tas

No evidence text available

18006306

3',5'-cyclic AMP affects NFKBIA

| 3

3',5'-cyclic AMP inhibits NFKBIA. 3 / 3

| 3

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➶

reach

"Moreover, shikonin suppressed the phosphorylation of p38, inhibitor of kappaB (IkappaB) kinase (IKK)-beta and IkappaB-alpha, and the subsequent IkappaB-alpha degradation induced by PMA+ cAMP; however, the PMA+ cAMP induced phosphorylation of extracellular signal related kinase (ERK), which resulted in minor inhibition and phosphorylation of c-Jun N-terminal kinase (JNK), seemed to be unaffected by shikonin treatment."

21806999

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➶

reach

"Although transfection studies suggest that PKA increases the activity of NF-kappaB, some reports have indicated that elevation of cAMP reduces NF-kappaB activity, possibly by stabilizing IkappaB-alpha and impairing the nuclear transport of p65 (Chen and Rothenberg 1994; Neumann et al. 1995)."

9150141

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reach

"While a notable body of literature suggest that HBx interacts with all major forms of NF-kappaB and activates target promoters bearing NF-kappaB, cAMP response element (CRE), and AP-1 consensus motifs; induces the degradation of p105 NF-kappaB1 and IkappaBalpha; or sequesters IkappaBalpha to sustain NF-kappaB activation (Robert Weil Direct Association and nuclear import of the HBx protein with the NF-KB inhibitor) where its activity is enhance by VHL binding protein (VBP1) in a cooperative manner; the mechanism for HBx activation of NF-kappaB remains undefined."

20010875

Zinc atom affects OAS2

| 2 1

Zinc atom inhibits OAS2. 2 / 2

| 1 1

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➶

sparser

"We estimated the Hill coefficient for the Zn 2+ inhibition of OAS2 to be approximately 1, indicating a non-co-operative binding of Zn 2+ to OAS2."

11682059

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➶

reach

"We estimated the Hill coefficient for the Zn 2+ inhibition of OAS2 to be approximately 1, indicating a non-co-operative binding of Zn 2+ to OAS2."

11682059

Zinc atom inhibits OAS2. 1 / 1

| 1

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➶

sparser

"Even though both OAS1 and OAS2 are strongly inhibited by zinc and by other metal ions as well, only OAS1 displays some co-operativity in the metal ion-mediated inhibition."

11682059

Oligonucleotide affects TLR7

| 2 1

Oligonucleotide inhibits TLR7. 2 / 2

| 2

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sparser

"Although the inhibitory effect of select LNA/DNA AMOs was surprising, it is consistent with a previous report that phosphorothioate DNA oligonucleotides can inhibit TLR7 sensing in a sequence-dependent manner ( xref )."

25539920

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sparser

"By contrast, substitution of 2′-O-methyl-C, 2′-O-methyl-5-methyl-C or 5-methyl-dC for C or 2′-O-methyl-G for G leads to loss of immune-stimulatory activity; further, such oligos inhibit TLR7- and TLR9-mediated immune responses ( xref )."

23396449

Oligonucleotide inhibits TLR7. 1 / 1

| 1

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➶

reach

"Their leader, IMO-8400 (also known as Bazlitoran, sequence: CTATCTNNNNTTCTCTNN), is an oligonucleotide antagonist of TLR7, TLR8 and TLR9, currently in clinical development (phase IIa) for the treatment of plaque psoriasis (NCT01899729) and dermatomyositis (NCT02612857) [346]."

32203790

Ginsenoside Rb1 affects RELA

| 3

Ginsenoside Rb1 inhibits RELA. 2 / 2

| 2

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➶

reach

"Our investigation found a noticeable increased expression of NF-κB p65 and its subsequent translocation into the nucleus 60mins after LPS stimulation in PMVECs (Figure 7A, middle), which was ameliorated by Ginsenoside Rb1, indicating that Ginsenoside Rb1 inhibited the activation of NF-κB p65 (Figure 7A, bottom)."

25530718

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➶

reach

"Our investigation found a noticeable increased expression of NF-kappaB p65 and its subsequent translocation into the nucleus 60mins after LPS stimulation in PMVECs, which was ameliorated by Ginsenoside Rb1, indicating that Ginsenoside Rb1 inhibited the activation of NF-kappaB p65."

25530718

Ginsenoside Rb1 inhibits phosphorylated RELA. 1 / 1

| 1

---

➶

reach

"In this study, LPS induced over phosphorylated NF-kappaB p65 was notably suppressed by Ginsenoside Rb1, in vitro."

25530718

Catechin affects MAP3K7

| 3

Catechin inhibits MAP3K7. 2 / 2

| 2

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➶

reach

"To further understand why EC and EGC differentially inhibited TAK1 kinase activity, we performed molecular docking of EC and EGC to the active site of TAK1."

28532672

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➶

reach

"EC alone inhibited 26% of p-TAK1 (Thr 184/187) expression whereas EGC alone inhibited by 35%."

28532672

Catechin inhibits MAP3K7. 1 / 1

| 1

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➶

reach

"When we looked at the expression of key signaling proteins in the IL-1beta signaling pathway, we found all the tested catechins could inhibit TAK-1 activity."

28532672

Berberine affects FOS

| 1 2

Berberine inhibits FOS. 2 / 2

| 2

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reach

"It has been reported that berberine decreases the motility and invasion of non small lung cancer cells by alleviating the activation of c-Fos, c-Jun, and NF-kappaB, and thus inhibits uPA, MMP2 proteins [XREF_BIBR]."

29130448

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➶

reach

"Berberine can inhibit the oncogentic H-Ras and c-fos in T24 cells, and can induce the activation of the caspase-3 and caspase-9 apoptosis."

21545798

Berberine inhibits FOS. 1 / 1

| 1

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➶

sparser

"Berberine can inhibit the oncogentic H-Ras and c-fos in T24 cells, and can induce the activation of the caspase-3 and caspase-9 apoptosis."

21545798

Apigenin affects RELA

| 3

Apigenin inhibits RELA. 2 / 2

| 2

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➶

reach

"Our studies performed through EMSA demonstrate that chamomile inhibits RelA and p65 activation."

21042790

---

➶

reach

"Our studies performed through EMSA demonstrate that chamomile inhibits RelA and p65 activation."

21042790

Apigenin bound to CHUK inhibits RELA. 1 / 1

| 1

---

➶

reach

"We found that apigenin directly binds with IKKalpha, attenuates IKKalpha kinase activity and suppresses NF-kB and p65 activation in human prostate cancer PC-3 and 22Rv1 cells much more effectively than IKK inhibitor, PS1145."

26435478

Acrolein affects NFKB1

1 2 |

Acrolein inhibits NFKB1. 2 / 2

2 |

---

➶

ctd

No evidence text available

15650393

---

➶

ctd

No evidence text available

17491020

Acrolein inhibits NFKB1. 1 / 1

1 |

---

➶

bel

""In contrast, DNA binding of NF-kB1 (p50) in nuclear extracts from acrolein-treated cells were decreased to levels seen in unstimulated cells...""

17491020

U0126 affects NFKBIA

| 1 2

U0126 inhibits NFKBIA. 2 / 2

| 2

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➶

reach

"Although the oleate activated AKT, IkappaBalpha and ERK were inhibited by LY294002, parthenolide and U0126, respectively, only LY294002 and parthenolide significantly inhibited the oleate induced PTX3 expression."

28489600

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➶

reach

"U0126 inhibition of IkappaBalpha processing is specific for the TPA signal transduction pathway, since this inhibitor did not interfere with TNF-alpha-induced processing of IkappaBalpha (lanes 10-12)."

11152962

U0126 inhibits NFKBIA. 1 / 1

| 1

---

➶

medscan

"The MEK inhibitor U0126 downregulated p-ERK, p-IκBα and p65 levels in SW620 cells. p65 activation in tumors with KRAS mutations was higher (50.8%) than in tumors with the wild-type KRAS gene (30.6%) (P=0.012)."

22327383

U0126 affects MAPK8

| 2 1

U0126 inhibits MAPK8. 2 / 2

| 1 1

---

➶

medscan

"To investigate downstream signaling through mitogen-activated protein kinases , experiments were performed in the presence of selective inhibitors of MEK1/2 (U0126), p38 MAP kinase (SB202190), or JNK (JNK inhibitor VIII, which inhibits JNK1/2/3)."

25050597

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➶

reach

"As shown in XREF_FIG (MTT assay) and XREF_FIG (annexin-V and PI double staining), SP600125 (an inhibitor of JNK-1, -2 and -3), SB202190 (an inhibitor of p38 MAPK-beta), and U0126 (an inhibitor of MEK1/2) each significantly reduced glutamate induced cell death in a concentration dependent manner."

20542495

U0126 inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"However, inhibition of the classic mitogen-activated protein kinase pathway using the PD98059 and U0126 inhibitors and inhibition of SAPK/JNK pathway did not suppress C pneumoniae-induced ICAM-1 expression."

12714566

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one affects JAK1

2 1 |

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one inhibits JAK1. 2 / 2

2 |

---

➶

tas

No evidence text available

26351728

---

➶

tas

No evidence text available

18844338

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one inhibits JAK1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

5'-S-methyl-5'-thioadenosine affects STAT1

| 1 2

5'-S-methyl-5'-thioadenosine inhibits STAT1. 2 / 2

| 1 1

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➶

sparser

"As a positive control, the specific inhibition of STAT1 by MTA and of NF-κB by Bay11-7082 was demonstrated using Western blot analysis ( Fig. 4 C and D)."

19371952

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➶

reach

"As a positive control, the specific inhibition of STAT1 by MTA and of NF-kappaB by Bay11-7082 was demonstrated using Western blot analysis."

19371952

5'-S-methyl-5'-thioadenosine inhibits tyrosine-phosphorylated STAT1. 1 / 1

| 1

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➶

reach

"EMSAs using the STAT1 specific GRR element as a probe revealed that MTA pretreatment reduced the ability of tyrosine phosphorylated STAT1 to bind DNA."

11257227

Auranofin affects IKBKB

| 3

Auranofin inhibits IKBKB-S181E. 1 / 1

| 1

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➶

reach

"Auranofin inhibited constitutively active IKKalpha and beta and variants; IKKalpha (S176E, S180E) or IKKbeta (S177E, S181E), suggesting that gold directly cause inhibition of activated enzyme."

12754408

Auranofin inhibits IKBKB-S177E. 1 / 1

| 1

---

➶

reach

"Auranofin inhibited constitutively active IKKalpha and beta and variants; IKKalpha (S176E, S180E) or IKKbeta (S177E, S181E), suggesting that gold directly cause inhibition of activated enzyme."

12754408

Auranofin inhibits IKBKB. 1 / 1

| 1

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➶

reach

"We showed that auranofin treatment (0, 25, 50 and 100 nM for 48 h) decreased the expression level of IKK-beta protein in the cytoplasm in a dose dependent manner."

25096914

Asn-Val affects DDX58

| 1 2

Asn-Val inhibits DDX58. 1 / 1

| 1

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➶

sparser

"Both NV proteins strongly inhibit RIG-I- and TBK1-mediated IRF3-dependent IFN and ISRE promoter activities."

28276468

Asn-Val bound to it inhibits DDX58. 1 / 1

| 1

---

➶

reach

"Since IHNV NV also interacts with PPM1Bb, recruits it in close vicinity to mitochondria and strongly inhibits the RIG-I pathway of interferon induction, it can be speculated that IHNV NV could redirect PPM1Bb phosphatase to another substrate such as IRF3 or DDX3 which are phosphorylated by TBK1 and involved downstream it in the RLR signaling."

28276468

Asn-Val bound to PPM1Bb inhibits DDX58. 1 / 1

| 1

---

➶

reach

"Since IHNV NV also interacts with PPM1Bb, recruits it in close vicinity to mitochondria and strongly inhibits the RIG-I pathway of interferon induction, it can be speculated that IHNV NV could redirect PPM1Bb phosphatase to another substrate such as IRF3 or DDX3 which are phosphorylated by TBK1 and involved downstream it in the RLR signaling."

28276468

Zinc atom affects RELA

2 |

Zinc atom inhibits RELA. 2 / 2

2 |

---

➶

ctd

No evidence text available

16606632

---

➶

ctd

No evidence text available

12429649

Zinc atom affects NLRP3

| 2

Zinc atom inhibits NLRP3. 2 / 2

| 2

---

➶

reach

"These results indicated that Zn inhibited NLRP3 inflammasome activation in the HG treated HPMCs by activating the Nrf2 antioxidant pathway and reducing the production of ROS."

28849014

---

➶

reach

"In conclusion, the present study demonstrated that HG induced NLRP3 inflammasome activation in HPMCs, whereas Zn treatment inhibited NLRP3 inflammasome activation by attenuating oxidative stress."

28849014

Zinc atom affects MYD88

| 2

Zinc atom inhibits MYD88. 2 / 2

| 2

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➶

reach

"To understand whether Zn inhibited MyD88 or TRIF signaling, or both, we queried whether Zn suppressed the proinflammatory response of DCs to TLR2 and TLR3 ligands."

27465530

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➶

reach

"Zn inhibits IkappaB kinase (IKK) and NF-kappaB downstream of MyD88 that could potentially attenuate a TLR4 response by dephosphorylation of these phosphate dependent kinases."

27465530

Wedelolactone affects NFKBIA

1 | 1

Wedelolactone inhibits NFKBIA. 2 / 2

1 | 1

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➶

ctd

No evidence text available

25450232

---

➶

reach

"In addition, wedelolactone is reported to inhibit IkappaBalpha phosphoration XREF_BIBR, consistent with the result of this study."

27558652

Water affects FOS

| 2

Water inhibits FOS. 2 / 2

| 2

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➶

reach

"(Right) Water induced suppression of c-fos occurs in both vasopressin (AVP) and oxytocin (OXY)-expressing neurons."

8899886

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➶

reach

"Water intake inhibits c-fos in the SON and PVN; whether this is a direct interaction between Ang-II and altered osmolality on magnocellular neurons or a secondary event of an action elsewhere (e.g., in the AV3V) remains uncertain."

8899886

Veliparib affects RELA

| 2

Veliparib inhibits RELA. 2 / 2

| 2

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➶

reach

"In addition, ABT-888 significantly inhibited NFkappaB (p65 and RelA) transcriptional activity in HER2+ but not HER2 negative breast cancer cells."

22987487

---

➶

reach

"In addition, ABT-888 significantly inhibited NFkappaB (p65 and RelA) transcriptional activity in HER2+ but not HER2 negative breast cancer cells."

22987487

Vanillin affects NFKB1

| 2

Vanillin inhibits NFKB1. 2 / 2

| 2

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➶

reach

"Vanillin Analogues o-Vanillin and 2,4,6-Trihydroxybenzaldehyde Inhibit NFkB Activation and Suppress Growth of A375 Human Melanoma."

27793895

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➶

reach

"The vanillin analogues o-vanillin and 2,4,6-trihydroxybenzaldehyde exhibited cytotoxicity against cultured A375 cells, and inhibited doxorubicin- and 4-hydroperoxycyclophosphamide-induced NFkB activation."

27793895

Valsartan affects RELA

| 2

Valsartan inhibits RELA. 2 / 2

| 2

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➶

reach

"Whereas valsartan treatment inhibited p65 and TF in the vascular wall, valsartan mediated the reduction of hypertrophy, it rather increased PCA per total protein in extracts of the left ventricle."

10880382

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➶

reach

"Although valsartan inhibited p65 and TF in the vascular wall, valsartan increased PCA per total protein in extracts of the left ventricle."

10880382

Valproic acid affects RELA

| 2

Valproic acid inhibits RELA. 2 / 2

| 2

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➶

reach

"In PANC-1 cells, 24 h of VPA treatment decreased RelA and p65 activity by approximately 25%, however, this effect could not be intensified by extension of treatment periods and was not statistically significant."

19912635

---

➶

reach

"In PANC-1 cells, 24 h of VPA treatment decreased RelA and p65 activity by approximately 25%, however, this effect could not be intensified by extension of treatment periods and was not statistically significant."

19912635

Valproic acid affects NFKBIA

| 2

Valproic acid inhibits NFKBIA. 2 / 2

| 2

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➶

reach

"Thereby, VPA could prolong the prostratin induced IkappaBalpha degradation by prolonging the IKK activity, as we have previously shown for the TNFalpha+ TSA combined treatment XREF_BIBR."

19564922

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➶

reach

"In this study, down-regulation of IkappaBalpha by VPA mediated the activation of NF-kappaB as evidenced by increased translocation of p65 and p50 to nucleus."

21722408

Valproic acid affects FOS

| 2

Valproic acid inhibits FOS. 2 / 2

| 2

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➶

reach

"Pretreatment with carbamazepine or valproate for 4 or 8 days combined with an injection immediately before noxious stimulation further significantly decreased the number of c-Fos neurons in the deep dorsal horn only in animals treated with valproate."

7789465

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➶

reach

"Single intraperitoneal injection of carbamazepine (50 mg/kg), valproate (300 mg/kg) or intravenous injection of phenytoine (20 mg/kg) before noxious stimulation reduced the number of c-Fos immunoreactive neurons to 65-80% of control levels in superficial laminae and to 30-60% in deep laminae of the dorsal horn."

7789465

Ursolic acid affects CHUK

| 2

Ursolic acid inhibits CHUK. 2 / 2

| 2

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➶

reach

"Encouragingly, the combination of ursolic acid and oxaliplatin remarkably inhibited p-ERK1/2, p-Akt, and p-IKKalpha, which was much more significant compared to those treated with ursolic acid or oxaliplatin alone."

27472952

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➶

reach

"While a mild decrease of p-ERK1/2, p-AKT, and p-IKKalpha was observed on the xenograft samples from mice treated with ursolic acid alone, oxaliplatin alone did not seem to have obvious effect on the phosphorylation status of these three molecules tested."

27472952

Ursodeoxycholic acid affects ITCH

| 2

Ursodeoxycholic acid inhibits ITCH. 2 / 2

| 2

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➶

reach

"Ursodeoxycholic acid (UDCA) treatment can reduce itch and lower endogenous serum bile acids in intrahepatic cholestasis of pregnancy (ICP)."

32127609

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➶

reach

"Using meta-analyses of randomized double-blind placebo controlled studies in which itch intensity was measured and longitudinally tracked, they reported that nalfurafine and gabapentin were effective for reducing uraemic itch, naltrexone reduced chronic itch from cholestasis and atopic dermatitis, and ursodeoxycholic acid reduced itch from intrahepatic cholestasis of pregnancy."

26415674

Troglitazone affects RELA

2 |

Troglitazone inhibits RELA. 2 / 2

2 |

---

➶

ctd

No evidence text available

12732648

---

➶

ctd

No evidence text available

17425601

Triazolopyridine affects MAPK14

2 |

Triazolopyridine inhibits MAPK14. 2 / 2

2 |

---

➶

tas

No evidence text available

16759861

---

➶

tas

No evidence text available

16134941

Trans-anethole affects NFKBIA

| 2

Trans-anethole inhibits NFKBIA. 2 / 2

| 2

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➶

reach

"Anethole suppressed the activation of NF-kappaB by blocking IkappaB-alpha degradation."

24513202

---

➶

reach

"Anethole suppressed the activation of NF-kappaB by blocking IkappaB-alpha degradation."

24404587

Trans-aconitic acid affects CASP1

| 2

Trans-aconitic acid inhibits CASP1. 2 / 2

| 2

---

➶

reach

"Results also demonstrated that TRA suppressed the NOD like receptor protein 3 (NLRP3) inflammasomes through blocking expressions of NLRP3, apoptosis associated speck like protein containing (ASC), and caspase-1 in both IL-1beta-induced HFLS-RA and CIA mice."

30851708

---

➶

reach

"Gambogic Acid Inhibits the Activation of NF-kappaB and Caspase-1."

24623960

Tranilast affects JUN

| 2

Tranilast inhibits JUN. 2 / 2

| 2

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➶

reach

"All rights reserved - 0024-3205/94 $ 6.00 +.00 0024-3205 (94) 00262-2 PHARMACOLOGY LETTERS Accelerated Communication INHIBITION BY TRANILAST OF COLLAGEN ACCUMULATION IN HYPERSENSITIVE GRANULOMATOUS INFLAMMATION IN VIVO AND OF MORPHOLOGICAL CHANGES AND FUNCTIONS OF FIBROBLASTS IN VITRO Masayuki Isaji *, Norisato Aruga, Jun Naito and Hiroshi Miyata Central Research Laboratories, Kissei Pharmaceutical Co., Ltd., 4365-1, Kashiwabara, Hotaka, Minamiazumi, Nagano-pref, 399-83 Japan (Submitted June 27, 1994; accepted July 19, 1994; received in final form August 1, 1994) Abstract."

7523821

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➶

reach

"Interleukin-1beta-induced Jun N-terminal kinase (JNK) activation was also suppressed selectively by tranilast."

11557268

Torin 1 affects CASP1

| 2

Torin 1 inhibits CASP1. 2 / 2

| 2

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➶

reach

"Torin1 suppressed caspase-1 activation in wild type BMDM in response to LPS and ATP, compared to vehicle control, while NLRP3 and ASC expression were unchanged (XREF_FIG)."

26119735

---

➶

reach

"Torin1 suppressed caspase-1 activation in wild-type BMDMs in response to LPS and ATP, compared to vehicle control, while NLRP3 and ASC expressions were unchanged."

26119735

Theophylline affects NFKB1

| 2

Theophylline inhibits NFKB1. 2 / 2

| 2

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➶

reach

"The impairment of p50 suppression by theophylline in normal subjects suggests a modulatory role of adenosine in sensory gating, which may be related to p50 suppression deficit in schizophrenia and is in agreement with a hypoadenosinergic model of schizophrenia."

12377399

---

➶

reach

"The adenosine antagonist theophylline impairs p50 auditory sensory gating in normal subjects."

12377399

Theophylline affects IRF7

| 2

Theophylline inhibits IRF7. 2 / 2

| 2

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➶

reach

"In this report, interferon regulatory factor 7 (IRF-7) and CD36 were both suppressed by theophylline in macrophages, especially in high dosages."

16083514

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➶

reach

"The IRF7, TAFII55, PRG1, GMCSF, TNF-alpha, IL-13 Ralpha1, IL-5, and IL-18 genes were suppressed by theophylline, whereas ETIF2S3, IL6ST, TESK1, IL-13 Ralpha2, VEGF-a, and VEGF-c were stimulated."

16083514

Theaflavin affects NFKBIA

| 2

Theaflavin inhibits NFKBIA. 2 / 2

| 2

---

➶

reach

"XREF_BIBR, XREF_BIBR Previously, theaflavin inhibited the activation of IKK and subsequent activation of the IkappaB-alpha and NF-kappaB pathway in human lung adenocarcinoma cells, macrophages, and mouse epidermal cells."

22111069

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➶

reach

"In addition, theaflavin inhibited tumor necrosis factor-alpha-mediated activation of IkappaB kinase and subsequent activation of the IkappaB-alpha and nuclear factor-kappaB pathway."

15483420

Thapsigargin affects NLRP3

| 2

Thapsigargin inhibits NLRP3. 2 / 2

| 2

---

➶

reach

"Sorbitol and thapsigargin did not suppress the activation of the NLRP3 inflammasome, whereas vincristine and paclitaxel strongly inhibited activation (XREF_FIG - XREF_FIG)."

31511697

---

➶

reach

"Thapsigargin (an inhibitor of SERCA mediated ER Ca 2+ reuptake) and Ca 2+ -free media both partially impair NLRP3 activation, suggesting redundancy between ER and extracellular Ca 2+ pools."

25879282

Tetramethylpyrazine affects MAPK14

| 2

Tetramethylpyrazine inhibits MAPK14. 2 / 2

| 2

---

➶

medscan

"2,3,5,6-tetramethylpyrazine inhibited arsenic-induced activations of JNK, p38 MAPK, ERK, AP-1 and Nrf2 and block HO-1 protein expression."

26404762

---

➶

medscan

"Ligustrazine attenuates the platelet-derived growth factor-BB-induced proliferation and migration of vascular smooth muscle cells by interrupting extracellular signal-regulated kinase and P38 mitogen-activated protein kinase pathways."

25738255

Tetracycline affects RELA

| 2

Tetracycline inhibits RELA. 2 / 2

| 2

---

➶

reach

"We have tested antibiotics tetracycline and chloramphenicol that inhibit translation and have been reported to abrogate RelA mediated ppGpp accumulation in live bacteria."

28115345

---

➶

reach

"To test this model, salmonellae were pretreated with tetracycline, an antibiotic that blocks the entry of tRNAs into the A site of ribosomes and thereby prevents classical RelA activation."

29487237

Testosterone affects NFKB1

| 2

Testosterone inhibits NFKB1. 2 / 2

| 2

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➶

reach

"FOXO3A is implicated in the regulation of NFkB inhibitors [XREF_BIBR], while estrogen [XREF_BIBR] and testosterone [XREF_BIBR] have also been shown to inhibit NFkB activity."

21093723

---

➶

reach

"The beneficial effects may be mediated by up-regulation of testosterone production, which in turn inhibits NFkB activation, leading to decreased cytokine and chemokine production and decreased chemotactic activity of leukocytes."

20827783

Tert-butyl hydroperoxide affects ITCH

| 2

Tert-butyl hydroperoxide inhibits ITCH. 2 / 2

| 2

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➶

reach

"Both hydrogen peroxide and tBHP induced itch can be reduced by either TrpA1 knockout or TrpA1 antagonist, revealing a novel itch mechanism where pruritogens directly target Trp channels (XREF_FIG)."

26385480

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➶

reach

"In contrast, morphine (1 mg/kg, i.p.) did not reduce H 2 O 2 or tBHP induced scratching behavior (XREF_FIG), consistent with clinical observations that morphine can only reduce pain but not itch [XREF_BIBR]."

22466125

Temozolomide affects NFKBIA

| 2

Temozolomide inhibits NFKBIA. 2 / 2

| 2

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➶

reach

"As shown in Figure XREF_FIG, expression of gammaH2AX and cleaved caspase-3, as well as reduction in Rad51 and RIP1 expression and sustained level of IkappaBalpha expression were significantly more enhanced in tumor extracts from animals treated with the inhibitor and TMZ, in comparison to non treated mice and mice treated with the RGD inhibitor or TMZ only, revealing the same molecular mechanism to occur also in vivo."

27487141

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➶

reach

"Both Ad.Egr-TNF and IR activate nuclear factor-kappaB, and temozolomide inhibits this activity in an inhibitor of kappaBalpha (IkappaBalpha)-independent manner."

17947489

Technetium atom affects RELA

| 2

Technetium atom inhibits RELA. 2 / 2

| 2

---

➶

reach

"Moreover, TC inhibited the upregulation of p65 NF-x03BA; B under in vitro psoriatic condition."

27383847

---

➶

reach

"ZnPP suppressed TC induced inhibition of p65 NF-x03BA; B expression."

27383847

Tanespimycin affects RIPK1

| 2

Tanespimycin inhibits RIPK1. 2 / 2

| 2

---

➶

reach

"In both H23 and HepG2 cells, the Hsp90 inhibitor 17AAG caused dramatic degradation of RIP1 and IKKbeta, two critical components for TNF-alpha-induced NF-kappaB activation, regardless of the presence of SMC3."

20862547

---

➶

reach

"A reduction in the cellular levels of RIP1 was also observed in those cell lines treated with 17AAG."

19632771

Tanespimycin affects IRF3

| 2

Tanespimycin inhibits IRF3. 2 / 2

| 2

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➶

reach

"Interestingly, we found that geldanamycin and its analog 17-AAG, which was previously known to inhibit IRF3 activation by RNA viruses, block MAVS aggregation."

21782231

---

➶

reach

"Taken together, these results suggest that geldanamycin and 17-AAG inhibit IRF3 activation by preventing MAVS aggregation on the mitochondria."

21782231

Tanespimycin affects IKBKB

| 2

Tanespimycin inhibits IKBKB. 2 / 2

| 2

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➶

reach

"17-AAG decreased IKK complex proteins, IKKalpha and IKKbeta."

18034886

---

➶

reach

"In both H23 and HepG2 cells, the Hsp90 inhibitor 17AAG caused dramatic degradation of RIP1 and IKKbeta, two critical components for TNF-alpha-induced NF-kappaB activation, regardless of the presence of SMC3."

20862547

Talmapimod affects MAPK14

2 |

Talmapimod inhibits MAPK14. 2 / 2

2 |

---

➶

tas

No evidence text available

19950901

---

➶

tas

No evidence text available

20071169

Tacrolimus (anhydrous) affects RELA

| 2

Tacrolimus (anhydrous) inhibits RELA. 2 / 2

| 2

---

➶

reach

"Furthermore, FK506 inhibited nuclear factor-kappaB activation and decreased mRNA levels of the p50 and p65 subunits of nuclear factor-kappaB."

10406194

---

➶

reach

"FK506 caused a 30-40% reduction in nuclear p65 and a more pronounced reduction (70-80%) of nuclear cRel, p50, and NFATc."

12732617

Tacrolimus (anhydrous) affects MAPK8

1 | 1

Tacrolimus (anhydrous) inhibits MAPK8. 2 / 2

1 | 1

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➶

reach

"In hypoxia-reoxygenation-subjected hepatocytes, tacrolimus reduced JNK1 and SAPK1 and caspase 3 activation."

12892836

---

➶

ctd

No evidence text available

12892836

Superoxide affects NFKBIA

| 2

Superoxide inhibits NFKBIA. 2 / 2

| 2

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➶

reach

"Mendes et al. reported that superoxide mediates interleukin-1beta-induced IkappaBalpha degradation and consequent NFkappaB activation in bovine articular chondrocytes 23."

24101667

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➶

reach

"It has also been reported that superoxide mediates interleukin-1beta-induced IkappaBalpha degradation and consequent NFkappaB activation in bovine articular chondrocytes."

26528122

Sulindac sulfide affects RELA

2 |

Sulindac sulfide inhibits RELA. 2 / 2

2 |

---

➶

ctd

No evidence text available

11912124

---

➶

ctd

No evidence text available

12085227

Sulforaphane affects PYCARD

| 2

Sulforaphane inhibits PYCARD. 2 / 2

| 2

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➶

reach

"Oral administration of SFN inhibited HFD induced upregulation of ASC and caspase-1 in the liver (XREF_FIG)."

27075683

---

➶

reach

"Consistently, SFN prevented palmitate induced oligomerization of ASC, another hallmark of inflammasome activation, as shown by speckle formation using confocal microscopy (XREF_FIG)."

27075683

Sulforaphane affects MYD88

| 1 1

Sulforaphane inhibits MYD88. 2 / 2

| 1 1

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➶

reach

"Sulforaphane could inhibit the TLR4 and MyD88 pathway and reduce the releasing of downstream inflammatory cytokines, suggesting that sulforaphane may have an anti-inflammatory effect in COPD."

24969711

---

➶

sparser

"Therefore, the obvious inhibition of TLR-4 and MyD88 by SFN in this study implied not only its protection but also its clinical applications in cardiovascular diseases."

20880684

Sulforaphane affects JUN

| 2

Sulforaphane inhibits JUN. 2 / 2

| 2

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➶

reach

"In particular, SFN increased pro survival ERK (extracellular signal regulated kinase) and antiapoptotic p38beta mitogen activated protein kinase, and decreased the proapoptotic Jun N-terminal kinase (JNK) and p38alpha pathways."

32425794

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➶

reach

"Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA binding domain : implications for chemoprevention of UVB induced skin cancer."

19671797

Sulfasalazine affects NFKB1

| 2

Sulfasalazine inhibits NFKB1. 2 / 2

| 2

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➶

reach

"Some of the observed effects of sulfasalazine could have arisen from aspirin like actions of the metabolite 5-ASA on cyclooxygenase, prostacyclin and thromoboxanes, which have been reported for non gestational tissues and where sulfasalazine is known to inhibit both NFkB and cytokine release [19,29]."

20884048

---

➶

reach

"In sickle mice, NFKB inhibition by sulfasalazine led to decreased leucocyte adhesion and improved microvascular blood flow."

19222472

Sucrose affects TLR7

| 2

Sucrose inhibits TLR7. 2 / 2

| 2

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➶

reach

"Figure 3: a | The 2′-O-methyl sugar modification prevents activation of the Toll-like receptor 7 immune response and confers enzymatic resistance to the siRNA molecule."

19180106

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➶

reach

"a | The 2′-O-methyl sugar modification prevents activation of the Toll-like receptor 7 immune response and confers enzymatic resistance to the siRNA molecule."

19180106

Streptomycin(3+) affects TRIM25

| 2

Streptomycin(3+) inhibits TRIM25. 2 / 2

| 2

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➶

reach

"Interestingly, streptomycin at 2 x 10-5 M, which causes misreading and also inhibits A-site occupation of the a type [17], is a potent inhibitor of the EF-P mediated reaction."

9195040

---

➶

reach

"Despite this cost in fitness, these mutants are not more susceptible to a wide range of antibiotics; including ribosome targeting antibiotics, such as lincomycin, chloramphenicol, and streptomycin, which have been shown previously to disrupt EF-P function in vitro."

23591475

Staurosporine affects TBK1

2 |

Staurosporine inhibits TBK1. 2 / 2

2 |

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➶

tas

No evidence text available

---

➶

tas

No evidence text available

22037378

Staurosporine affects MAP3K7

2 |

Staurosporine inhibits MAP3K7. 2 / 2

2 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

19397322

Staurosporine affects FOS

| 2

Staurosporine inhibits FOS. 2 / 2

| 2

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➶

reach

"The Ang II evoked c-fos induction was blocked only by high doses of staurosporine and by zeta-PS whilst PD098059, LY294002 and wortmannin were ineffective, thus indicating that c-fos induction is not due to ERK1/2 activity."

12942541

---

➶

reach

"Staurosporin inhibited the induction of c-fos by hypergravity almost completely at a concentration of 0.1 microM, but it inhibited the induction of egr-1 only partially."

7510248

Sorafenib affects RELA

| 1 1

Sorafenib inhibits RELA. 2 / 2

| 1 1

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➶

reach

"Chromatin immunoprecipitation (ChIP) assays demonstrated that fluvastatin and sorafenib synergistically inhibited the binding of NF-kappaB p65 subunit to the SDF-1alpha promoter."

28423574

---

➶

medscan

"The receptor tyrosine kinase inhibitor sorafenib inhibited RelA activity, which then promoted c-mip expression."

24067439

Sodium(1+) affects JUN

| 2

Sodium(1+) inhibits JUN. 2 / 2

| 2

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➶

reach

"It was also recently reported that sodium salicylate and aspirin suppressed the activation of activator protein-1 in mouse epidermal cells exposed to UVB light [21]."

10594377

---

➶

reach

"Pentosan polysulfate (PPS) sodium inhibits IL-1beta-induced iNOS, c-Jun and HIF-1alpha mRNA upregulation."

28472120

Sodium chloride affects PYCARD

| 2

Sodium chloride inhibits PYCARD. 2 / 2

| 2

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➶

reach

"Salt stress significantly reduced the contents of ASC and GSH as well as activities of ASC-GSH cycle enzymes such as ascorbate peroxidase (APX), monodehydroascorbate reductase (MDHAR), dehydroascorbate reductase (DHAR), and glutathione reductase (GR)."

17223225

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➶

reach

"On the other hand, the concentrations of malondialdehyde, a product of lipid peroxidation, remained unchanged in this plant, and the ASC content even decreased in leaves treated with different concentrations of NaCl."

24465083

Sodium atom affects RELA

| 2

Sodium atom inhibits RELA. 2 / 2

| 2

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➶

reach

"Whether NA could suppress constitutive NF-kappaB and p65 activation was also examined."

25575821

---

➶

reach

"Reporter gene data suggested that constitutive NF-kappaB and p65 activation was suppressed by NA at various concentrations."

25575821

Sodium atom affects PYCARD

| 2

Sodium atom inhibits PYCARD. 2 / 2

| 2

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reach

"Na (+)-dependent L-alanine transport, but not MeAIB transport, was partially inhibited by L-serine and L-cysteine, indicating the participation of system ASC."

11171637

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➶

reach

"Not shown is a feature causing methionine and norleucine to exert a Na +-independent inhibition of ASC trans port, not associated with their own transports."

5474782

Sodium atom affects JAK1

| 1 1

Sodium atom inhibits JAK1. 2 / 2

| 1 1

---

➶

eidos

"Therefore , JAK1 diminishment by Na + / K + - ATPase inhibitors / antagonists may not arise from their targeting of Na + / K + - ATPase ; and Na + / K + - ATPase independent JAK1 diminishment by natural cardenolides and bufadienolides could be the basis for their clinical benefits in the diseases they are used to treat ."

| PMC

---

➶

reach

"Therefore, JAK1 diminishment by Na + / K + -ATPase inhibitors and antagonists may not arise from their targeting of Na + / K + -ATPase; and Na + / K + -ATPase independent JAK1 diminishment by natural cardenolides and bufadienolides could be the basis for their clinical benefits in the diseases they are used to treat."

| PMC

Sodium atom affects CASP1

| 2

Sodium atom inhibits CASP1. 2 / 2

| 2

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➶

reach

"Moreover, Na 2 S attenuated caspase-1 activity (50% reduction, P < 0.05; XREF_FIG) and cell death (51% reduction, P < 0.05, XREF_FIG) in cardiomyocytes challenged with LPS+ATP as compared to control cells."

24825878

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➶

reach

"NA inhibited NLRP3 inflammasome activation and subsequent caspase-1 cleavage as well as interleukin (IL)-1beta secretion."

27614220

Sodium arsenite affects RELA

2 |

Sodium arsenite inhibits RELA. 2 / 2

2 |

---

➶

ctd

No evidence text available

15028728

---

➶

ctd

No evidence text available

12676792

Sirolimus affects STAT1

| 1 1

Sirolimus inhibits STAT1. 2 / 2

| 1 1

---

➶

reach

"Sirolimus enhances immature DC tolerogenicity by induction of T-cell apoptosis, and promotes immature DC induced inhibition of Stat1, ERK and ATF-2 activation."

16507425

---

➶

medscan

"More importantly, other data directly support the idea that rapamycin inhibits the activity of signal transducer and activator of transcription1 ."

23554911

Simvastatin affects RIPK1

| 2

Simvastatin inhibits RIPK1. 2 / 2

| 2

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reach

"Simvastatin pretreatment inhibited the immunoreactive area of protein activity of caspase-8 (p < 0.01, Fig. 2), caspase-9 (p < 0.05, Fig. 2), and RIPK1 (p < 0.05, Fig. 2) 6 h after allograft reperfusion when compared to vehicle treated control group with 4-hour cold ischemia."

27155462

---

➶

reach

"Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion."

27155462

Simvastatin affects RELA

| 2

Simvastatin inhibits RELA. 2 / 2

| 2

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reach

"Neither quinapril nor simvastatin given for 7 d produced a suppression of ROS generation, intranuclear NF-kappa B, p65, or CRP, and these two agents did not alter cellular I kappa B either."

12970329

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➶

reach

"Simvastatin therapy also significantly reduced monocytic nuclear factor-kappaB p65 activity, compared with placebo (P < 0.01)."

17519305

Simvastatin affects CASP1

1 | 1

Simvastatin inhibits CASP1. 2 / 2

1 | 1

---

➶

reach

"Our results show that statin lowering of prenylation isoprenoids activate caspase-1 and IL-1beta inflammasome responses that impair endocrine control of adipocyte lipogenesis."

31010959

---

➶

ctd

No evidence text available

16054375

Silver(1+) affects STAT1

| 2

Silver(1+) inhibits STAT1. 2 / 2

| 2

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➶

reach

"The nuclear translocation patterns of p65 (NF-kappaB), members of the AP-1 family (c-Fos, c-Jun, ATF-2, Fra-1, and CEBP), and STAT-1 are shown in Figures XREF_FIG and XREF_FIG, and AG suppressed nuclear localization of c-Fos, phospho-ATF-2, and phospho-STAT-1."

23840248

---

➶

reach

"AG Inhibits Activation of AP-1 and STAT-1 in Macrophages."

23840248

Silver(1+) affects FOS

| 2

Silver(1+) inhibits FOS. 2 / 2

| 2

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➶

reach

"We next ascertained that the ROS scavenger NAC, the EGFR inhibitor AG, the MEK inhibitor PD and the ROCK inhibitor Y prevent c-fos induction by LA (XREF_FIG)."

28924490

---

➶

reach

"The nuclear translocation patterns of p65 (NF-kappaB), members of the AP-1 family (c-Fos, c-Jun, ATF-2, Fra-1, and CEBP), and STAT-1 are shown in Figures XREF_FIG and XREF_FIG, and AG suppressed nuclear localization of c-Fos, phospho-ATF-2, and phospho-STAT-1."

23840248

Silicon dioxide affects NFKBIA

| 2

Silicon dioxide inhibits NFKBIA. 2 / 2

| 2

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➶

reach

"N-Acetylcysteine and diphenyleneiodonium, both of which inhibit the accumulation of intracellular ROS, each blocked silica induced degradation of IkappaB-alpha but had no effect on that of the Prx enzymes, suggesting that ROS do not contribute to Prx proteolysis."

10558905

---

➶

reach

"LPS and silica both induce degradation of IkappaB-alpha, and MG132 prevents LPS induced, but not silica induced, IkappaB degradation and NF-kappaB activation [63]."

9920280

Silibinin affects NFKBIA

| 2

Silibinin inhibits NFKBIA. 2 / 2

| 2

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➶

reach

"The results showed that the expression of p-JNK, P-ERK, p-P38, p-IkappaBalpha, and p-NF-kappaBp65 in the liver tissue was increased after the injection of CCL 4, while the Yi Guan Jian and silymarin could significantly reduce p-JNK, P-ERK, p-P38, p-IkappaBalpha, and p-NF-kappaBp65 in liver tissue."

30891081

---

➶

reach

"As the upstream events of NF-kappaB activation, the level of p-IKKalpha was dramatically increased, whereas the expression of IkappaBalpha was substantially decreased after hypoxia and reperfusion, treated with silibinin markedly hindered the phosphorylation of IKKalpha and degradation of IkappaBalpha, respectively."

32398964

Serotonin affects NFKBIA

| 2

Serotonin inhibits NFKBIA. 2 / 2

| 2

---

➶

reach

"Chronic clozapine treatment augments NF-kappaB function via serotonin 5-HT 2A -receptor dependent downregulation of IkappaBalpha."

28783139

---

➶

reach

"Chronic clozapine treatment augments NF-kappaB function via serotonin 5-HT 2A -receptor dependent downregulation of IkappaBalpha."

28783139

Selenium atom affects NFKBIA

| 2

Selenium atom inhibits NFKBIA. 2 / 2

| 2

---

➶

reach

"Se treatment decreased phosphorylated forms of p65, IkappaBalpha, p38, JNK and ERK in a concentration dependent manner."

29340029

---

➶

reach

"In summary, Se 2 Mo 10 V 3 inhibits tumor growth both in vitro and in vivo and induces apoptosis in K562 cells at least in part by inhibiting NF-kappaB and IkappaBalpha."

28978080

Seaborgium atom affects TICAM1

| 2

Seaborgium atom inhibits TICAM1. 2 / 2

| 2

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➶

reach

"SG proteins expressed in cells did not affect the RIG-I and MDA5 pathway but inhibited the TLR adaptor TRIF and TICAM -1 pathway for ISRE activation."

18611945

---

➶

reach

"RSV sG protein expression in HEK293 cells could inhibit the TLR adaptor TRIF and TICAM-1-dependent activation of an interferon stimulated responsive element (ISRE) in transient transfection assays, suggesting that RSV G targets this adaptor to inhibit TLR3/4 dependent signaling."

21632720

Seaborgium atom affects IFNB1

| 2

Seaborgium atom inhibits IFNB1. 2 / 2

| 2

---

➶

reach

"Finally, extrinsically added sG protein suppressed the production of IFN-beta in mDCs."

18611945

---

➶

reach

"have shown that addition of RSV soluble G (sG) protein suppresses the production of IFN-beta in moDCs stimulated with LPS."

21632720

Scutellarin(1-) affects CASP1

| 2

Scutellarin(1-) inhibits CASP1. 2 / 2

| 2

---

➶

reach

"The results showed that scutellarin dose-dependently reduced caspase-1 activation and decreased mature interleukin-1beta (IL-1beta) release in lipopolysaccharide (LPS)-primed macrophages upon ATP or nigericin stimulation, indicating that scutellarin inhibited NLRP3 inflammasome activation in macrophages."

29375379

---

➶

reach

"Consistent with these studies, our results showed that scutellarin not only inhibited caspase-1 activation and pyroptosis but also blocked mature IL-1beta secretion into culture supernatants."

29375379

Salicylic acid affects NFKBIA

| 2

Salicylic acid inhibits NFKBIA. 2 / 2

| 2

---

➶

reach

"We have shown in rats that sodium salicylate (SS), which inhibits IkBa kinase B (IKKB), prevents hepatic and peripheral insulin resistance caused by short-term (7h) i.v. administration of Intralipid and heparin (IH)."

23328071

---

➶

reach

"Although inhibition of IkappaBalpha phosphorylation has previously been reported in cells treated with sodium salicylate, treatment of MCF-7 cells with sodium salicylate in this study led to only a modest (less than 25%) inhibition of TNFalpha stimulated IkappaBalpha phosphorylation."

20959117

Salicylic acid affects CHUK

| 2

Salicylic acid inhibits CHUK. 2 / 2

| 2

---

➶

reach

"Salsalate belongs to the salicylate drug class, which has been shown to inhibit I-kappaB kinase, thereby inhibiting the nuclear factor-kappaB (NF-kappaB) cascade and decreasing the production of inflammatory cytokines, as well as decreasing insulin resistance."

25126374

---

➶

reach

"In vitro, salicylate treatment comparably inhibited the kinase activity of overexpressed IKKalpha and IKKbeta and also decreased p38 kinase activity."

10753891

Salicylate affects NLRP3

| 2

Salicylate inhibits NLRP3. 2 / 2

| 2

---

➶

reach

"Furthermore, Sal B reduced the expression levels of IL-1beta and NLRP3 inflammasome in a dose dependent manner."

31816891

---

➶

reach

"Our data indicate that SAL inhibit NLRP3 related pyroptosis, which might be the underlying mechanism of SAL anti-inflammatory in atherosclerosis."

32076940

Salicylate affects NFKBIA

| 2

Salicylate inhibits NFKBIA. 2 / 2

| 2

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➶

reach

"Furthermore, after TNF-alpha treatment for 0.5 h, Sal B significantly suppressed IkappaBalpha activation (TNF-alpha group vs. control group, P = 0.001; Sal B 1 mumol/L vs. TNF-alpha group, P = 0.048; Sal B 5 mumol/L vs. TNF-alpha group, P = 0.006; Sal B 10 mumol/L vs. TNF-alpha group, P = 0.001)."

26415806

---

➶

reach

"The results showed that Sal inhibited the increase of TLR4, MyD88, p-IkappaBalpha and p-NF-kappaB in LPS induced BV2 cell (XREF_FIG)."

32432571

Ryanodine affects JUN

| 2

Ryanodine inhibits JUN. 2 / 2

| 2

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➶

reach

"In normal myotubes, 10 micro M nifedipine, but not ryanodine, inhibited c-jun and c-fos mRNA increase after K (+) depolarization."

12508050

---

➶

reach

"In normal myotubes, 10 muM nifedipine, but not ryanodine, inhibited c-jun and c-fos mRNA increase after K + depolarization."

12508050

Rutin affects NLRP3

| 2

Rutin inhibits NLRP3. 2 / 2

| 2

---

➶

reach

"Additionally, troxerutin suppressed NLRP3 inflammasome activation induced by BDE-47 in the kidneys of mice, while only troxerutin treatment did not significantly affect the parameters (no significance versus the control group)."

29849929

---

➶

reach

"Troxerutin Suppresses the Activity of NLRP3 Inflammasome Caused by BDE-47."

29849929

Rottlerin affects NFKB1

| 2

Rottlerin inhibits NFKB1. 2 / 2

| 2

---

➶

reach

"To help elucidate which intracellular signalling pathways the K562 cell line and PMA-I stimulation of NK cells were acting through, additional functional assays were performed with immune cell inhibitor drugs LY294002 (inhibitor of Pi3K activity), PD98059 (inhibitor of MEK in MAPK pathway), Rapamycin (inhibitor of mTOR) and Rottlerin (inhibitor of PKC in the NFkB pathway)."

23555904

---

➶

reach

"These included clinically used immunosuppressive drugs such as a calcineurin inhibitor (Cyclosporine A), an anti-proliferative agent (MPA) and a corticosteroid (Prednisolone), but also the additional intracellular signalling inhibitor drugs Rapamycin (inhibitor of mTOR), Rottlerin (inhibitor of PKC in the NFkB pathway), LY294002 (inhibitor of Pi3K activity) and PD98059 (inhibitor of MEK in MAPK pathway)."

23555904

Ribavirin affects STAT1

| 2

Ribavirin inhibits STAT1. 2 / 2

| 2

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➶

reach

"Furthermore, decrease of virus replication in the ribavirin treated persistently infected cells resulted in the restoration of IFN induced STAT-1, p48, IRF-1 and PKR induction, though induction of STAT-2 was at a lower level than the others In the same category, expression of MHC class-I was also restored in ribavirin treated Akata-MP1 and K-MTP cells."

10581390

---

➶

reach

"3.5 Ribavirin administration abrogates viremia of ZIKV infected STAT1 deficient mice."

28818572

Retinoic acid affects PYCARD

| 1 1

Retinoic acid inhibits PYCARD. 2 / 2

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"RA Inhibits Adipocyte Differentiation of Human ASCs at Early Stages."

26936961

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"However, the RA dose used for embryonic stem cells ' commitment into adipocytes is 0.1 to 1 mumol/L; we found that as little as 0.1 mumol/L RA is sufficient to inhibit ASC adipogenesis (data not shown)."

26936961

Resveratrol affects TRAF6

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Resveratrol inhibits TRAF6. 2 / 2

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"In human chondrocytes, resveratrol can remarkably suppress the upregulation of TLR4 and the downstream target MyD88 and TRAF6 induced by IL-1beta [XREF_BIBR]."

28203259

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"Resveratrol (50 muM) mediated the degradation of TRAF6 which in turn facilitated repression of the NF-kappaB pathway."

31712163

Resveratrol affects STAT1

| 1 1

Resveratrol inhibits STAT1. 2 / 2

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"In this respect, resveratrol decreased STAT1 activation (an important transcription factor for IFN-γ-induced genes) and hindered JAK-2 activation (Chung et al., 2011)."

| PMC

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eidos

"In this respect , resveratrol decreased STAT1 activation ( an important transcription factor for IFN-gamma-induced genes ) and hindered JAK-2 activation ( Chung et al ., 2011 ) ."

| PMC

Resveratrol affects JAK1

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Resveratrol inhibits JAK1. 2 / 2

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"Resveratrol was also found to markedly reduce the constitutive activation of Janus kinases (JAK1 and JAK2) in 786-O and Caki-1 cells."

29495357

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"Resveratrol treatment also decreased IL-6, TNF-alpha, IFN-gamma, JAK1, and STAT3 mRNA expression levels as compared with BTBR control mice in the brain tissue."

29654783

Resiquimod affects TLR7

1 | 1

Resiquimod inhibits TLR7. 2 / 2

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"Furthermore, gp120 did not inhibit IFN-alpha production in response to TLR7 activation by R-848 at 1 microg/ml (p = 0.35, NS) (XREF_FIG)."

23100517

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No evidence text available

Regorafenib affects FOS

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Regorafenib inhibits FOS. 2 / 2

| 2

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"Regorafenib downregulates c-FOS expression , resulting in the suppression of AP-1 activation , which is occasionally seen in sorafenib-resistant HCC [ 9,10 ] ."

32397371

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"Interestingly , regorafenib downregulated c-FOS expression , resulting in the suppression of AP-1 activation , which is occasionally seen in sorafenib-resistant HCC [ 9,10 ] ."

32397371

Reactive oxygen species affects TRAF6

| 2

Reactive oxygen species inhibits TRAF6. 2 / 2

| 2

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"In addition, the application of YPFS increased DDP induced ROS accumulation and MMP depletion, decreased p62 and TRAF6 signalling in DDP treated A549 and DDP cells."

27558312

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"Moreover, N-acetyl-L-cysteine, an ROS scavenger, suppressed the TRAF6 accumulation induced by oxygen-glucose deprivation via suppression of ROS bursts."

32253651

Reactive oxygen species affects RIPK1

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Reactive oxygen species inhibits RIPK1. 2 / 2

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"ROS scavengers blocked shikonin induced inactivation of Akt and RIP1 and NF-kappaB, but Akt or RIP1 and NF-kappaB did not regulate ROS generation, suggesting that Akt and RIP1 and NF-kappaB signals are downstream of ROS generation."

22011623

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"In addition, ROS scavenger (N-acetyl-L-cysteine, NAC) and NOX4 inhibitor GKT137831 reduced ROS generation and alleviated activation of Xbp1 and RIPK1 related NF-kappaB signaling."

27929749

Reactive oxygen species affects IFNB1

| 2

Reactive oxygen species inhibits IFNB1. 2 / 2

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"We further found that the IFNbeta stimulation by MPYS can be inhibited by high levels of ROS, and ROS stimulate MPYS oxidation as manifest by formation of intermolecular disulfide bonds within MPYS homodimers."

21170271

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"We conclude that sustained cellular ROS inhibit MPYS induction of IFNbeta."

21170271

Reactive oxygen species affects FOS

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Reactive oxygen species inhibits FOS. 2 / 2

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"Taken together, our data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway."

20432471

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"Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway."

20432471

Quetiapine affects NFKB1

| 2

Quetiapine inhibits NFKB1. 2 / 2

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"EIS uses the antifungal drug itraconazole to block Hedgehog signaling (Hh), the antidiabetes drug metformin to block AMP kinase (AMPK), the analgesic drug naproxen to block Rac1, the anti-fibrosis drug pirfenidone to block transforming growth factor-beta (TGF-beta), the psychiatric drug quetiapine to block receptor activator NFkB ligand, (RANKL) and the antibiotic rifampin (also called rifampicin) to block beta-catenin nuclear functions- all by their previously established ancillary attributes."

28977822

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"EIS Regimen uses the antifungal drug itraconazole to block Hedgehog signaling, the antidiabetes drug metformin to block AMP kinase (AMPK), the analgesic drug naproxen to block Rac1, the anti-fibrosis drug pirfenidone to block transforming growth factor-beta (TGF-beta), the psychiatric drug quetiapine to block receptor activator NFkB ligand (RANKL) and the antibiotic rifampin to block Wnt- all by their previously established ancillary attributes."

28977822

Quercetin affects MAPK8

1 | 1

Quercetin inhibits MAPK8. 2 / 2

1 | 1

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No evidence text available

10718847

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"Moreover, quercetin attenuated PI3K, Akt, ERK2, JNK1, and p38 MAPK activations, which were supported by platelet aggregation inhibition with the respective kinase inhibitors."

23304202

Quercetin affects FOS

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Quercetin inhibits FOS. 2 / 2

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"Western blotting showed that siRNA mediated inhibition of PPAR-gamma transcription led to an increase in AP-1 (c-fos, c-jun) protein expression in H9C2 cells, indicating that quercetin, at least in part, deregulates c-fos and c-jun via the PPAR-gamma signaling pathway."

24039778

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"We hypothesized that quercetin mediated inhibition of cardiac hypertrophy would be accompanied by increased activation of PPAR-gamma and reduced activation of AP-1 (c-fos, c-jun) both in vivo and in vitro."

24039778

Quercetin affects CHUK

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Quercetin inhibits CHUK. 2 / 2

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"Quercetin inhibits the purified recombinant IκB kinases, IKK1 and IKK2, by serving as a mixed-type inhibitor versus ATP [16] ."

11543732

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"Here we demonstrate that quercetin and staurosporine potently inhibit both IKKalpha and IKKbeta."

10551820

Pyrrolidine dithiocarbamate affects NFKB1

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Pyrrolidine dithiocarbamate inhibits NFKB1. 2 / 2

2 |

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No evidence text available

14527959

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No evidence text available

10661865

Pyrimidine affects JAK1

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Pyrimidine inhibits JAK1. 2 / 2

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"XREF_BIBR, XREF_BIBR, XREF_BIBR AZD1480 is a novel pyrazol pyrimidine ATP-competitive inhibitor of JAK1 and 2 kinases, with IC50 's of 1.3 and < 0.4 n, respectively, in enzyme assays."

22829094

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"Additionally, the pyrazolyl pyrimidine AZD1480, which potently inhibits JAK1 (IC 50 value of 1.3 nM) and JAK2 (IC 50 value of 0.4 nM) 186, differentially suppressed STAT1, STAT3, STAT5 and STAT6 activation at 0.1-5 muM concentration in prostate, ovarian, glioma, and breast cancer cells in vitro XREF_BIBR, XREF_BIBR."

23903221

Pyrimethamine affects RELA

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Pyrimethamine inhibits RELA. 2 / 2

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"These results demonstrate that pyrimethamine negatively regulates p65 and NF-kappaB activity (XREF_FIG) in CRPC cells through a mechanism involving the inhibition of p38 MAPK."

32523533

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"These data suggest that pyrimethamine negatively regulates p65 and NF-kappaB activity in CRPC cells through a mechanism involving p38 MAPK inhibition (XREF_FIG)."

32523533

Pyridoxamine affects CASP1

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Pyridoxamine inhibits CASP1. 2 / 2

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"Moreover, PM treatment suppressed caspase-1 activation (XREF_FIG, t = 6.011, p = 0.004) and IL-1betaproduction (XREF_TABLE, F = 3.612, p = 0.032)."

32410849

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"41 The observed PM 10 -induced downregulation of both caspase-1 and NLPR3 gene transcripts in epithelial cells contrasts with data for hematopoietic cells stimulated with NLRP3 inflammasome activators, 42 suggesting that the airway epithelium and inflammatory cells might regulate this gene differently."

22227418

Pterostilbene affects NLRP3

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Pterostilbene inhibits NLRP3. 2 / 2

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"Furthermore, pterostilbene was able to inhibit the inflammasome NLRP3 and caspase -1 (CASP1) pathway, being a promising agent for the treatment of AD."

32362821

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"Pterostilbene inhibits amyloid-beta-induced neuroinflammation in a microglia cell line by inactivating the NLRP3 and caspase -1 inflammasome pathway."

29737568

Psoralidin affects RELA

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Psoralidin inhibits RELA. 2 / 2

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"Inhibition of TNF-α by psoralidin inhibited NF-κB p65 and other pro-survival signaling molecules including IAP (cIAP and XIAP) and the Bcl-2 (Bcl-xL, data not shown) family of proteins."

19851870

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"Inhibition of TNF-α by psoralidin inhibited NF-κB p65 and other pro-survival signaling molecules including IAP (cIAP and XIAP) and the Bcl-2 (Bcl-xL, data not shown) family of proteins."

19851870

Pseudouridine affects TLR7

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Pseudouridine inhibits TLR7. 2 / 2

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"of pseudouridine ( Psi ) , 5methylcytidine ( m5C ) , 2thio uridine ( s2U ) or N6methyladenosine ( m6A ) was found to potently inhibit TLR7 and TLR8 and to reduce TLR3 activity , which is the least sensitive receptor to RNA modifications 88 ."

27455396

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"Incorporation of pseudouridine (Ψ), 5-methylcytidine (m5C), 2-thio-uridine (s2U) or N6-methyladenosine (m6A) was found to potently inhibit TLR7 and TLR8 and to reduce TLR3 activity, which is the least sensitive receptor to RNA modifications88."

27455396

Protein affects TRIM25

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Protein inhibits TRIM25. 2 / 2

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"Gack et al. recently showed that this protein interacts with and blocks the activity of TRIM25 , an E3 ligase required for ubiquitin-dependent interaction between RIG-I and IPS1 [ 22 * * ] ."

20699190

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"This protein also binds to and inhibits TRIM25 and PKR ."

22027189

Protein affects IRF3

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Protein inhibits IRF3. 2 / 2

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"M protein interacts with TRAF3 and suppresses IRF3 activity ."

30146782

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"We have identified at least ten viral IFN antagonists and all ten proteins inhibit the IRF3 activity ."

26773386

Prostaglandins affects CASP1

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Prostaglandins inhibits CASP1. 2 / 2

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"In this work we show that cyclopentenone prostaglandins inhibit activation of caspase-1 and maturation of IL-1beta by the NLRP1 and NLRP3 inflammasomes."

25681332

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"We report that the eicosanoid 15-deoxy-Delta 12,14 -prostaglandin J2 (15d-PGJ2) and related cyclopentenone prostaglandins inhibit caspase-1 activation by the NLRP1 and NLRP3 inflammasomes."

25681332

Prostaglandin I2 affects STAT1

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Prostaglandin I2 inhibits STAT1. 2 / 2

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"For the first time our data define detailed transcriptional mechanisms by which PGI2 inhibits MCP-1 production via the critical cardiovascular inflammatory axis of IFN-γ-STAT1 in monocytes."

19915063

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"We found that PGI2 inhibits the phosphorylation-dependent activation of the transactivation domain (phospho-STAT1-S727), thereby reducing the recruitment of CBP/p300 and thus MCP-1 production."

19915063

Prostaglandin E2-UM affects CASP1

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Prostaglandin E2-UM inhibits CASP1. 2 / 2

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"To assess the effect of PGE 2 on NLRP3 inflammasome activation, we first examined whether PGE 2 could inhibit caspase-1 cleavage and IL-1beta secretion."

25917098

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"We found that caspase-1 cleavage and IL-1beta secretion was also decreased by PGE 2 in an ATP- (XREF_FIG) or nigericin- (XREF_FIG) induced NLRP3 inflammasome activation model."

25917098

Prostaglandin E1 affects RELA

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Prostaglandin E1 inhibits RELA. 2 / 2

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"The OA-induced activation of nuclear factor (NF) κB p65 was also reduced by alprostadil."

30296789

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"The OA induced activation of nuclear factor (NF) kappaB p65 was also reduced by alprostadil."

30296789

Progesterone affects MYD88

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Progesterone inhibits MYD88. 2 / 2

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"By inhibiting miR-155 expression progesterone can down-regulate both MyD88 and TRIF dependent signaling pathways as well as IL-6 and IFN-beta production."

23372573

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"Estrogen and progesterone appear to inhibit MyD88, thereby illustrating how clinical and tumor related factors - chemotherapy, MyD88, and estrogen and progesterone - might together plausibly give rise to interactions that modify clinical outcomes."

26780780

Probenecid affects NLRP3

| 2

Probenecid inhibits NLRP3. 2 / 2

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"Overall, AZ11645373 and probenecid were approximately fivefold less potent than MCC950 which we have previously used (i.e., 12.5-50muM) to inhibit the effects of the NLRP3 activators and PB1-F2 (Coll et al., 2015; Pinar et al., 2017)."

31271646

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"Probenecid inhibited NLRP3 activation in cultured neurons and astrocytes by providing a high extracellular concentration of K + and decreased caspase-1 expression in the brains of aged rats."

28337127

Probenecid affects CASP1

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Probenecid inhibits CASP1. 2 / 2

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"In addition probenecid has been shown to attenuate the caspase 1 cleavage in cultured neurons induced by extracellular potassium ions."

24672487

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"Furthermore, the Panx1 channel inhibitor probenecid attenuates the caspase 1 cleavage in cultured neurons induced by extracellular potassium ions, further corroborating the involvement of Panx1 in inflammasome activation."

22771709

Pregnenolone affects TRAF6

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"Interestingly, pregnenolone did not inhibit TRAF6 or CRF, suggesting that structural requirements for inhibition of TLR signaling are cell type specific, and likely related to the requirements of the binding partners - both TLR4 and GABA A R alpha2 subunits."

30718548

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"While pregnenolone lacks GABAergic activity, and failed to block TRAF6 or CRF, it is possible that it may interfere with TLR4 and MyD88 binding and/or the PKA - pCREB pathway in the VTA."

30718548

Prazosin affects FOS

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Prazosin inhibits FOS. 2 / 2

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"Prazosin reduced FCL (SD)-induced elevations of c-jun and c-fos, but not NGFI-A, mRNA."

11072104

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"In confirmation, marked c-fos responses that were blocked by an alpha (1)-antagonist (prazosin) were found in four of these brain regions (secondary motor, cingulate, piriform cortices, and nucleus accumbens) of animals exposed to a mildly novel environment (clean cage), which elicits a high degree of sustained exploratory activity."

16419046

Pramocaine affects ITCH

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Pramocaine inhibits ITCH. 2 / 2

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"14 A small pilot study in patients with pruritus from undefined etiologies demonstrated that topical application of hydrocortisone acetate 2.5% and pramoxine hydrochloride 1% in a hydrolipid lotion reduced pruritus by 30% from baseline as rated by patients using the visual analog scale within 24 hours of initiation of therapy."

21767774

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"52 Pramoxine, which is thought to exert anti-pruritic effects by stabilizing membranes of sensory nerves, effectively decreases itch in patients with xerosis, uremic pruritus, and psoriasis and has been used as a single agent or in combination with mild potency topical steroids or lactic acid lotion."

21767774

Potassium chloride affects CASP1

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Potassium chloride inhibits CASP1. 2 / 2

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"DPI and exogenous KCl also decreased caspase-1 activation in monocytes treated with U1-snRNP and anti-U1-snRNP antibody positive serum although the endolysomal inhibitor chroloquine could not suppressed caspase-1 activation (XREF_FIG)."

22490866

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"In our data, 120 mM KCl, but not 60 mM KCl, partially attenuated caspase-1 activation by S. typhimurium, but glybenclamide, another inhibitor of K + efflux, did not reduce Salmonella induced caspase-1 activation and ASC oligomerization."

23396959

Ponatinib affects RIPK1

| 1 1

Ponatinib inhibits RIPK1. 2 / 2

| 1 1

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"Ponatinib has been shown to inhibit both RIP1 and RIP3 via direct binding [XREF_BIBR, XREF_BIBR]."

28978109

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eidos

"In addition , the activity of RIPK1 , an NSP12 interactor which is associated with apoptosis , necroptosis , and inflammatory pathways , is predicted to be inhibited by ponatinib and pazopanib ."

32444466

Poly(cytidylic acid) affects NFKBIA

| 2

Poly(cytidylic acid) inhibits NFKBIA. 2 / 2

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"Thus, it was reported that polyinosinic and polycytidylic acid activates PKR from macrophages (Gusella et al., 1995) and also induces I-kappaBalpha degradation (Heitmeir et al., 1998)."

12176113

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"Heitmeir et al. (1998) also observed I-kappaBalpha degradation in macrophages treated with polyinosinic and polycytidylic acid which is a synthetic double stranded RNA.On the basis of these data, we suggest a model for the mechanism of action of L-RNA."

12176113

Poly I:C affects IFIH1

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Poly I:C inhibits IFIH1. 2 / 2

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"When the RLRs were simultaneously overexpressed in the poly I : C transfected cells, the activity of LGP2 promoter did not significantly change although the MDA5 overexpressing cells stimulated by 80 and 400 ng poly I : C were slightly decreased compared to the others."

23251565

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"Although the induction of IFN-beta by AIV was weaker than that after poly I : C stimulation (probably due to viral NS1 mediated inhibition of MDA5 signaling and induction of IFN-beta activity), our results agree with those of a previous study showing that silencing of cMDA5 and cTLR3 in WT cells results in a significantly reduced induction of IFN-beta activity after stimulation with poly I : C or infection of AIV."

32425931

Poly I:C affects DDX58

| 2

Poly I:C inhibits DDX58. 2 / 2

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"Furthermore, low-molecular weight (LMW) poly I : C initiated RIG-I signaling was suppressed when DrNOD2 or DrNOD2 (DeltaLRR) was co-injected in zebrafish embryos (XREF_FIG F)."

28555019

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"DrRIG-I could negatively regulate MDP initiated NOD2 signaling, and DrNOD2 could negatively regulate LMW poly I : C initiated RIG-I signaling."

28555019

Plumbagin affects RELA

| 2

Plumbagin inhibits RELA. 2 / 2

| 2

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"In addition, NF-kappaB and p65 activation in RAW 264.7 cells was decreased by plumbagin (XREF_SUPPLEMENTARY)."

27756878

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"Plumbagin also suppressed the direct binding of nuclear p65 and recombinant p65 to the DNA, and this binding was reversed by dithiothreitol both in vitro and in vivo."

16624823

Pioglitazone affects RELA

| 2

Pioglitazone inhibits RELA. 2 / 2

| 2

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"Wan et al. have shown that the PPAR gamma activator pioglitazone could attenuate caerulein induced p50 and p65 NF and kappaB dimer activity in the nucleus of caerulein treated AR42J cells [84]."

27282980

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"Herein, we report that oral administration of the pioglitazone reduced the NF-kappaB p65 activity in the lumbar spinal cord."

26394827

Piceatannol affects STAT1

| 2

Piceatannol inhibits STAT1. 2 / 2

| 2

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"To characterize that the signaling pathways of IL-17A increase K17 expression in HaCaT cells, fludarabine and piceatannol were used to selectively inhibit STAT1 and STAT3 signaling, respectively."

21796151

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"Consistent with this, pretreatment of DCs with a Syk inhibitor, piceatannol, inhibited the up-regulation of P-STAT1, as well as maturation induced by anti-FcgammaRIIB (XREF_FIG)."

17502666

Piceatannol affects MYD88

| 2

Piceatannol inhibits MYD88. 2 / 2

| 2

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"Piceatannol Suppresses MyD88 Dependent IRAK1 Activation."

28680194

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"Indeed, we found that overexpression of myeloid differentiation primary response gene 88 (MyD88), an adaptor molecule that drives TLR signaling, induced IRAK1 expression and that piceatannol, a Syk inhibitor, successfully suppressed the MyD88 dependent upregulation of IRAK1 under LPS treatment conditions."

28680194

Piceatannol affects MAPK8

| 2

Piceatannol inhibits MAPK8. 2 / 2

| 2

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"While ERK activation is rapid and transient, peaking at 10 min, the JNK1 activation is delayed and more sustained reaching a maximum at 2 h. ERK activation was blocked by CP 118556, indicating it is regulated by a Src like kinase, while JNK1 was inhibited by piceatannol, revealing an upstream regulation by Syk."

10528214

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"SAPK1 and JNK1 activation was blocked by piceatannol, indicating that it is regulated by Syk kinase, whereas SAPK2 and p38 activation was inhibited by PP2, revealing an upstream regulation by Src like kinases."

11154209

Piceatannol affects JAK1

| 2

Piceatannol inhibits JAK1. 2 / 2

| 2

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"Piceatannol also inhibits JAK-1, which is a key member of the STAT pathway that is crucial in controlling cellular activities in response to extracellular cytokines and is a COX-2-inducible enzyme involved in inflammation and carcinogenesis."

22108298

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"In contrast, additional treatment with Piceatannol which inhibit the NF-kappaB and JAK-1 and STAT signaling [XREF_BIBR] abolished the effect of betulin to increase IL-12p70."

25756279

Phosphatidic acid affects NLRP3

| 2

Phosphatidic acid inhibits NLRP3. 2 / 2

| 2

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"Taken together, these data suggested that AdipoRon suppressed PA induced myocardial cell injury by suppressing Nlrp3 inflammasome activation."

31749627

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➶

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"However, SalA treatment had no inhibitory effects on the PA induced activation of the NLRP3 inflammasome and the pro inflammatory cytokine secretion in TXNIP siRNA transfected HepG2 cells."

27345365

Phosphatidic acid affects NFKBIA

| 2

Phosphatidic acid inhibits NFKBIA. 2 / 2

| 2

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"PA stimulation promotes macrophage I kappa B alpha (IkappaBalpha) degradation, janus kinase (JNK) phosphorylation, with TNF-alpha and IL-6 secretion in vitro."

27128935

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"In NRK-52E cells treated with PA for 30 min, EGFR silencing inhibited PA induced IkappaBalpha degradation and protein expression of cell adhesion molecules VCAM-1 and ICAM-1."

27014908

Phorbol 13-acetate 12-myristate affects RELA

1 | 1

Phorbol 13-acetate 12-myristate inhibits RELA. 2 / 2

1 | 1

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➶

ctd

No evidence text available

16174796

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"Nuclear translocation of TPA induced p65 (a NF-kappaB subunit) and c-fos (an AP-1 subunit) was suppressed by BITC, PEITC, and SFN, whereas that of c-jun (an AP-1 subunit) was not."

28969043

Phenylmethanesulfonyl fluoride affects RELA

| 2

Phenylmethanesulfonyl fluoride inhibits RELA. 2 / 2

| 2

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"The presence of the serine proteases inhibitor PMSF abrogated the cleavage of p65 and RelA in both, in vivo and in vitro cleavage assays (XREF_FIG) further suggesting that the involved secreted meningococcal protein is most likely a serine protease that is able to reach the nuclear compartment of infected cells."

26241037

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"The presence of the serine proteases inhibitor PMSF abrogated the cleavage of p65 and RelA in both, in vivo and in vitro cleavage assays (XREF_FIG) further suggesting that the involved secreted meningococcal protein is most likely a serine protease that is able to reach the nuclear compartment of infected cells."

26241037

Phenylephrine affects NLRP3

| 2

Phenylephrine inhibits NLRP3. 2 / 2

| 2

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"Moreover, PE induced NLRP3 inflammasome activation and cardiac inflammation was blocked in Nlrp3 -/- mice compared with wild-type mice."

31530901

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"We identified NLRP3 as a negative regulator of cardiomyocyte remodeling in PE stimulated cardiomyocyte remodeling using adenovirus-NLRP3 and NLRP3 siRNA."

30159587

Phenyl isocyanate affects IFNB1

| 2

Phenyl isocyanate inhibits IFNB1. 2 / 2

| 2

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"We observed that the turnover rate of PIC induced IFN-beta mRNA was slower compared to that of TNF-alpha mRNA (approximately 40 versus 20 min, respectively)."

22200507

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"In general, the NS1 proteins derived from WNV, YFV and DENV were transiently transfected into HeLa and HEK293 cells without inhibiting the pIC mediated IFNbeta and downstream cellular gene production [XREF_BIBR]."

28991176

Phenethyl caffeate affects IRF3

| 2

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| 2

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"CAPE suppressed production of inflammatory mediators and activation of NFkappaB and interferon-regulatory factor 3 (IRF3) in macrophages stimulated with LPS."

23231684

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➶

reach

"CAPE is yet able to suppress IRF-3 activation, following inflammation or innate immune response [XREF_BIBR] but this activity may follow cell regulation of virus infection, which allows that the E3 ubiquitin ligase RBCC protein interacting with PKC1 (RBCK1) binds to IRF-3 and targets it for ubiquitination and subsequent degradation through a proteasome dependent pathway, to dampen the overexpression of RBCK1 by virus and reduce side effects as autoimmune disorders due to the excessive activity of IFNs [XREF_BIBR]."

27104045

Pevonedistat affects NFKBIA

| 1 1

Pevonedistat inhibits NFKBIA. 2 / 2

| 1 1

---

➶

eidos

"These included pevonedistat ( MLN4924 ) , a NEDD8-activating enzyme ( NAE ) inhibitor , which blocks NFkappaB activation by preventing the NEDDylation and consequent degradation of IkappaBalpha.44 ,45 Also tested were the MEK inhibitor trametinib ,46 the p38 MAPK inhibitor VX-745 ,47 and JNK inhibitor 8 ( JNKi8 ) .48,49 In JAK2 mutant HEL cells , pevonedistat was shown to inhibit degradation of IkappaBalpha ( Figure 7a ) , without affecting levels of p-p65 / RELA or pSTAT3 / 5 ( Figure 7a , b ) ."

30718771

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➶

reach

"Given that 1) matrix metalloproteinase 9 (MMP-9) promotes cell migration XREF_BIBR, 2) MMP-9 is a known target of NFkappaB XREF_BIBR and 3) MLN4924 inactivates NFkappaB by causing accumulation of IkappaBalpha (XREF_FIG), we determined potential involvement of MMP-9 in cell migration and found that MLN4924 effectively inhibited expression of MMP-9mRNA in both gastric cancer cell lines (XREF_FIG)."

27063292

Pevonedistat affects IFNB1

| 2

Pevonedistat inhibits IFNB1. 2 / 2

| 2

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➶

reach

"MLN4924, a First-in-Class NEDD8 Activating Enzyme Inhibitor, Attenuates IFN-beta Production."

26895833

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➶

reach

"The ability of the MLN4924 to inhibit IFN-beta production was confirmed in vivo, as mice treated with MLN4924 exhibited decreased levels of IFN-beta upon LPS or polyinosinic-polycytidylic acid stimulation."

26895833

Pentobarbital affects JUN

2 |

Pentobarbital inhibits JUN. 2 / 2

2 |

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➶

ctd

No evidence text available

19346066

---

➶

ctd

No evidence text available

17545946

Pazopanib hydrochloride affects RIPK1

2 |

Pazopanib hydrochloride inhibits RIPK1. 2 / 2

2 |

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➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

Parthenolide affects PYCARD

| 2

Parthenolide inhibits PYCARD. 2 / 2

| 2

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reach

"However, parthenolide inhibited the formation of ASC pyroptosome induced by LPS plus ATP."

28415686

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➶

reach

"In agreement with the effects seen previously on IL-1beta secretion and caspase-1 activation glyburide and parthenolide did not inhibit AIM2 dependent ASC oligomerisation."

22216309

Parthenolide affects MYD88

| 2

Parthenolide inhibits MYD88. 2 / 2

| 2

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reach

"Other signaling inhibitors including antiapoptotic protein A20, agonistic lipid A and its analogues, inhibitors of IkB2, salicylate and parthenolide, NF-B kinases inhibitor PS-1145, inhibitors of p38, JNK, anti-TLR, anti-MyD88 antibodies, are able to target the TIR domain of the TLR4 or the MyD88 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

28373830

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➶

reach

"Parthenolide inhibits the MyD88 dependent pathway by inhibiting the activity of inhibitor-kappaB kinase."

21347702

Parthenolide affects CHUK

| 2

Parthenolide inhibits CHUK. 2 / 2

| 2

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➶

reach

"Parthenolide significantly inhibited IL-8 secretion induced by these cytokines and prevented NF-kappaB activation, IkappaBalpha degradation, and IkappaB Kinase complex activity."

17272824

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➶

reach

"The IKK inhibitors parthenolide and aspirin blocked the activities of infection induced IKKalpha and IKKbeta, leading to attenuation of nuclear translocation of NF-kappaB."

15618150

Paricalcitol affects TRAF3

| 1 1

Paricalcitol inhibits TRAF3. 2 / 2

| 1 1

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➶

eidos

"In VDR knockout mice with renal injury , paricalcitol prevented TRAF3 downregulation and NF - kappa B2-dependent gene upregulation , suggesting a VDR-independent anti-inflammatory effect of paricalcitol ."

32631974

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reach

"In VDR knockout mice with renal injury, paricalcitol prevented TRAF3 downregulation and NF- kappa B2 dependent gene upregulation, suggesting a VDR independent anti-inflammatory effect of paricalcitol."

32631974

Panobinostat affects NFKB1

| 2

Panobinostat inhibits NFKB1. 2 / 2

| 2

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➶

reach

"Our current study shows that NF-kappaB1 is significantly suppressed by LBH589 treatment, similar to that reported previously in colon cancer [XREF_BIBR]."

23160924

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➶

reach

"In the current study, we focused on elucidating the mechanism underlying LBH589 's effects on AI resistant cell lines, and showed that LBH589 inhibits the NF-kappaB1 pathway."

23160924

Pamapimod affects MAPK14

2 |

Pamapimod inhibits MAPK14. 2 / 2

2 |

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tas

No evidence text available

19950901

---

➶

tas

No evidence text available

21375264

Palmitoyl ethanolamide affects ITCH

| 2

Palmitoyl ethanolamide inhibits ITCH. 2 / 2

| 2

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reach

"71 N-palmitoylethanolamine, a cannabinoid receptor CB2 agonist, has been compounded into creams and shown to reduce pruritus within days in patients with AD, lichen simplex chronicus, prurigo nodularis, and uremic pruritus."

21767774

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➶

reach

"Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitis."

27720681

Oxo group affects MAP3K7

| 2

Oxo group inhibits MAP3K7. 2 / 2

| 2

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➶

sparser

"Oxo inhibited TAK1-, TAK1/TAB2-, and TAK1/TAB3-stimulated reporter activity at concentrations as low as 0.5 μM, without affecting basal reporter activity ( Figs."

22549017

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"Oxo inhibited TAK1-, TAK1/TAB2-, and TAK1/TAB3-stimulated reporter activity at concentrations as low as 0.5 μM, without affecting basal reporter activity ( Figs."

22549017

Oseltamivir affects NLRP3

| 2

Oseltamivir inhibits NLRP3. 2 / 2

| 2

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reach

"Delayed oseltamivir and sirolimus combined treatment could suppress NLRP3 inflammasome mediated secretion of IL-1beta and IL-18, resulting in attenuation of H1N1 induced lung injury [XREF_BIBR]."

32235330

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➶

reach

"In an experimental animal model of H1N1 influenza, rapamycin in combin ation with oseltamivir reduced viral replication and the NLRP3 inflammasome."

32422178

Oligonucleotide affects STAT1

| 2

Oligonucleotide inhibits STAT1. 2 / 2

| 2

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➶

sparser

"We therefore sought to examine whether the STAT3 decoy oligonucleotide inhibited STAT1 in endothelial cells."

24404126

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➶

sparser

"For example, overexpression of Stat1 in cultured cardiomyocytes enhances apoptotic cell death, while inhibition of Stat1 by antisense oligonucleotides decreased cell death in response to I/R injury [ xref ]."

27764156

Nordihydroguaiaretic acid affects STAT1

| 2

Nordihydroguaiaretic acid inhibits STAT1. 2 / 2

| 2

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reach

"Indeed, NDGA was able to inhibit activation of the downstream signaling proteins STAT1, STAT3 and MAPK."

18794123

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➶

reach

"In our results reported here, we found that NDGA, an agent previously shown to disrupt the Golgi by mechanisms distinct from BFA, rapidly blocked activation of STAT1 and STAT3."

18794123

Nordihydroguaiaretic acid affects JUN

1 | 1

Nordihydroguaiaretic acid inhibits JUN. 2 / 2

1 | 1

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➶

sparser

"However, NDGA also inhibits the Ap-1 transcription factor ( xref ; xref ; xref ), while its effects on other transcription pathways important in tumor biology have not been explored."

19540220

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➶

tas

No evidence text available

24831826

Non-steroidal anti-inflammatory drug affects JUN

| 2

Non-steroidal anti-inflammatory drug inhibits JUN. 2 / 2

| 2

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➶

sparser

"To this end, some NSAIDs inactivate the transcription factors NF-κB and activator protein-1 (e.g. aspirin and COX-2-selective inhibitors) or activate the peroxisome proliferator-activated receptor-γ (PPAR-γ; e.g. indomethacin and ibuprofen)."

19269697

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sparser

"NSAIDs are able to inactivate the transcription NF-kB and activator protein-1 (AP-1), critically involved in the induction of multiple inflammatory gene products involved in the inflammatory response (i.e. iNOS, TNF-α)."

21092260

Nocodazole affects STAT1

| 2

Nocodazole inhibits STAT1. 2 / 2

| 2

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reach

"STAT1 activation upon IFNgamma influence is blocked by nocodazole, but does not depend on the activity of Src family kinases."

15747831

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➶

reach

"STAT1 and STAT3 activation upon EGF is blocked by both nocodazole and Src-kinase family inhibitor."

15747831

Nitric oxide affects STING1

| 2

Nitric oxide inhibits STING1. 2 / 2

| 2

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reach

"Furthermore, we show that NO 2 -FAs can inhibit STING signaling and the release of type I IFNs in response to stimulation with the STING agonists, dsDNA and cGAMP, in addition to infection with the DNA virus HSV-2."

30061387

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➶

reach

"Additionally, NO 2 -FA treatment of immortalized fibroblasts from SAVI patients led to decreased STING dependent type I IFN responses."

30061387

Nitric oxide affects RIPK1

| 2

Nitric oxide inhibits RIPK1. 2 / 2

| 2

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reach

"These results indicate that NO donor induces necrostatin-1-inhibitable necrotic beta-cell death independent of RIP1."

21888904

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➶

reach

"Together, these results clearly indicate that Nec-1 and Nec-1i inhibit NO donor induced necrotic cell death independent of the inhibition of RIP1 in beta-cells."

21888904

Nitric oxide affects IKBKB

| 1 1

Nitric oxide inhibits IKBKB. 2 / 2

| 1 1

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reach

"Recently, Sarkar et al. [XREF_BIBR] demonstrated that NO could inhibit autophagy by S nitrosylating and thus inhibiting the activities of IKKbeta and JNK1, potent inducers of autophagy."

22899934

---

➶

medscan

"Nitric oxide impairs autophagy by inhibiting the activity of S-nitrosylation substrates, JNK1, and IKKβ."

26356821

Nilotinib affects MAPK14

2 |

Nilotinib inhibits MAPK14. 2 / 2

2 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

26789553

Nifedipine affects JUN

| 2

Nifedipine inhibits JUN. 2 / 2

| 2

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reach

"In normal myotubes, 10 micro M nifedipine, but not ryanodine, inhibited c-jun and c-fos mRNA increase after K (+) depolarization."

12508050

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➶

reach

"In normal myotubes, 10 muM nifedipine, but not ryanodine, inhibited c-jun and c-fos mRNA increase after K + depolarization."

12508050

Nicotinic acid affects NLRP3

| 2

Nicotinic acid inhibits NLRP3. 2 / 2

| 2

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reach

"We found that, unlike BHB, niacin did not block the NLRP3 inflammasome activation (XREF_FIG, XREF_SUPPLEMENTARY)."

25686106

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➶

reach

"Nicotinic acid inhibits NLRP3 inflammasome activation via SIRT1 in vascular endothelial cells."

27614220

Nicotinamide affects CASP1

| 2

Nicotinamide inhibits CASP1. 2 / 2

| 2

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reach

"Moreover, other studies have shown that nicotinamide does indeed prevent the induction of the pro apoptotic proteins caspase-1, caspase-3 and caspase-8 and thereby afford neuroprotection (Chong et al., 2002; Lin et al., 2000)."

12782109

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➶

reach

"Current studies demonstrate that nicotinamide prevents the induction of caspase-8, caspase-1 and caspase-3-like activities during cellular injury [3,4,13]."

12767721

Nicorandil affects CASP1

| 2

Nicorandil inhibits CASP1. 2 / 2

| 2

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➶

reach

"Recently, nicorandil was reported to reduce the activation of the inflammasome and the release of caspase-1, IL-1beta and IL-18, following oxygen-glucose deprivation induced inflammation in BV-2 cells."

26035532

---

➶

reach

"Recently, nicorandil was reported to reduce the activation of the inflammasome and the subsequent release of caspase-1, interleukin (IL)-1beta and IL-18."

26035532

Nickel(2+) affects IRF3

| 2

Nickel(2+) inhibits IRF3. 2 / 2

| 2

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➶

reach

"The present study demonstrated that nickel decreased interferon regulatory proteins IRF3 and IRF7, and activated NF- kappaB, resulting in DeltaNp63 suppression and then p21 up-regulation."

21466819

---

➶

reach

"In summary, our results showed that in keratinocytes nickel is able to decrease IRF3 and IRF7, and then activate NF-kappaB."

21466819

Nevirapine affects IFNB1

| 2

Nevirapine inhibits IFNB1. 2 / 2

| 2

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reach

"As previous reported in MEF, nevirapine abrogated IFNbeta, Isg15, Il6, and Rantes induction upon HIV-VSV infection, but raltegravir had no effect."

27078069

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➶

reach

"AZT and NVP, even at high concentrations, did not inhibit IFNbeta induction by HT-DNA (XREF_SUPPLEMENTARY), indicating that the inhibitory effects of AZT and NVP were due to their specific inhibition of HIV reverse transcription."

23929945

Neamine affects NFKB1

| 2

Neamine inhibits NFKB1. 2 / 2

| 2

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➶

reach

"Neamine treatment also significantly decreased activity (nuclear location) of Angiogenin and NFkB compared to PBS treated T1DM-MCAo control rats."

24211797

---

➶

reach

"Neamine decreased RAGE, TLR4 and NFkB activity."

24211797

Naloxone affects NLRP3

| 2

Naloxone inhibits NLRP3. 2 / 2

| 2

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➶

reach

"We elucidated whether naloxone could inhibit the activation of NLRP3 inflammasome."

29078913

---

➶

reach

"Naloxone inhibits NLRP3 inflammasome activation."

29078913

Naloxone affects FOS

| 2

Naloxone inhibits FOS. 2 / 2

| 2

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➶

reach

"However, although naloxone blocked the expression of pentylenetetrazol induced hippocampal c-Fos [104], it did not block seizure activity [104,344], suggesting that the increased neuronal excitability is not directly related to seizure activity, but may be related to the memory impairments often observed after epileptic seizures [104]."

10698131

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➶

reach

"Surprisingly, in many regions c-Fos induction by morphine was reduced or blocked by naloxone, even though these subjects had also experienced the effects of morphine for 30 min prior to antagonist administration."

17631915

Nalbuphine affects ITCH

| 2

Nalbuphine inhibits ITCH. 2 / 2

| 2

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reach

"Nalbuphine suppressed itch in a dose dependent manner, reducing mean VAS score from 4.0 to 1.2 at 180mg and 0.4 at 240mg."

25885112

---

➶

reach

"Nalbuphine suppressed itch in a dose dependent manner in 12/14 patients, reducing itch from a mean VAS score of 4.0 (range, 1.3-6.6) to 1.2 and 0.4 at 180mg and 240mg, respectively."

25885112

Myricetin affects NLRP3

| 2

Myricetin inhibits NLRP3. 2 / 2

| 2

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➶

reach

"Another report has shown that treatment with myricetin, a plant‐derived flavonoid, inhibits NLRP3 inflammasome."

31679183

---

➶

reach

"Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS dependent ubiquitination of ASC and promotion of ROS independent NLRP3 ubiquitination."

30594691

Myricetin affects JUN

| 2

Myricetin inhibits JUN. 2 / 2

| 2

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➶

reach

"Myricetin, but not resveratrol, attenuated tumor promoter induced activation of c-fos or activator protein-1."

17693661

---

➶

reach

"Myricetin, but not resveratrol, attenuated tumor promoter induced activation of c-fos or activator protein-1."

19325788

Morphine(1+) affects JUN

| 2

Morphine(1+) inhibits JUN. 2 / 2

| 2

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➶

reach

"Morphine inhibits activator protein 1 activation by a mu opioid receptor pathway coupled to nitric oxide as second messenger."

17583593

---

➶

reach

"The transcription factor activator protein-1, NF-kappaB, and nuclear factor of activated T cells (NFAT) were negatively regulated by morphine."

12842891

Minocycline affects ITCH

| 2

Minocycline inhibits ITCH. 2 / 2

| 2

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➶

reach

"Intrathecal Minocycline Suppresses Itch Related Behavior and Improves Dermatitis in a Mouse Model of AtopicDermatitis."

26827761

---

➶

reach

"The results showed that the expression of microglial marker ionized calcium binding adaptor molecule-1 was significantly increased after 5% imiquimod treatment in cervical spinal cord dorsal horn (C3-C4), and the intrathecal microglial inhibitor minocycline or PLX5622 diet suppressed both spontaneous itch and microglial activation."

32580615

Minocycline affects IFNB1

| 2

Minocycline inhibits IFNB1. 2 / 2

| 2

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reach

"Minocycline treatment decreased the production of IFNalpha (XREF_FIG; p < 0.0001) and IFNbeta (XREF_FIG; p < 0.0001) and attenuated TRAIL upregulation in response to AT-2 HIV (XREF_FIG; p = 0.006)."

24732038

---

➶

reach

"Minocycline treatment prevented secretion of both IFNalpha (XREF_FIG; p = 0.031) and IFNbeta (XREF_FIG; p = 0.031, respectively) by pDCs in response to AT-2 HIV stimulation, maintaining type I IFNs in the supernatant at nearly undetectable levels."

24732038

Midostaurin affects TBK1

2 |

Midostaurin inhibits TBK1. 2 / 2

2 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

Midostaurin affects MAP3K7

2 |

Midostaurin inhibits MAP3K7. 2 / 2

2 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

Methanol affects ITCH

| 2

Methanol inhibits ITCH. 2 / 2

| 2

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➶

reach

"Inhibitory effects of the methanol extract of Ganoderma lucidum on mosquito allergy induced itch associated responses in mice."

20948166

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➶

reach

"When administrated perorally (p.o.) at a dose of 200 mg/kg, methanol extracts of Sophora flavescens and Cnidium monnieri, but not the others, significantly inhibited a serotonin (5-HT)-induced itch related response (scratching) and the spontaneous scratching of NC mice, a mouse model of atopic dermatitis."

12736520

Metformin affects NFKB1

| 2

Metformin inhibits NFKB1. 2 / 2

| 2

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➶

reach

"Metformin combined with CO-1686 synergistically inhibited the p-IkappaB, p-IKKa and beta, p50 and p65."

30307719

---

➶

reach

"These results suggest that metformin blocks SCC growth by dampening NFkB and mTOR signaling pathways."

22540890

Metformin affects JUN

| 2

Metformin inhibits JUN. 2 / 2

| 2

---

➶

reach

"Metformin may also inhibit ERK signaling and Ca (2+)-dependent PKC-alpha and ERK and JNK and activator protein 1 pathways."

29184536

---

➶

reach

"In these cells, metformin also suppressed phorbol-12-myristate-13-acetate (PMA)-enhanced levels of matrix metalloproteinases-9 (MMP-9) protein, mRNA and transcription activity through suppression of activator protein-1 (AP-1) activation."

20590612

Melatonin affects STAT1

| 2

Melatonin inhibits STAT1. 2 / 2

| 2

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➶

reach

"Melatonin attenuated the increased levels of JAK2 and STAT1 activation as well as IFN-beta, and ZnPP reversed these inhibitory effects of melatonin."

22288937

---

➶

reach

"Melatonin blocked NF-kappaB signaling through the inhibition of nuclear translocation and DNA binding activity of NF-kappaB p50 subunit and suppressed STAT1 signaling."

21158907

Melatonin affects NFKB1

| 2

Melatonin inhibits NFKB1. 2 / 2

| 2

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➶

reach

"* Melatonin : Melatonin has been shown to inhibit NFkB activation and NLRP3 inflammasome activation."

32229082

---

➶

reach

"Because melatonin reduces constitutive NFKB activation in cultured pineal glands, we propose that this indolamine regulates this transcription factor pathway in the rat pineal gland, but not at the LD transition."

20205557

Masoprocol affects JUN

1 | 1

Masoprocol inhibits JUN. 2 / 2

1 | 1

---

➶

tas

No evidence text available

24831826

---

➶

medscan

"C) nordihydroguaiaretic acid impairs c-Jun or c-Fos recruitment at peptidylarginine deiminase Intergenic Enhancer in calcium-stimulated Normal Human Epidermal Keratinocytes."

18923650

Mangiferin affects RELA

| 2

Mangiferin inhibits RELA. 2 / 2

| 2

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➶

reach

"Mangiferin treatment markedly reduced the NF-kappaB p65 activation in the colon."

25194678

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➶

reach

"Increased expression and distribution of EGF, FGF, TGF-beta, VEGF, PI3K, MMP and Nrf2 and decreased expression and distribution of TNFalpha and NF-kappaB p65 were observed in diabetic wound treated with topical mangiferin."

32013660

Malonaldehyde affects TLR7

| 2

Malonaldehyde inhibits TLR7. 2 / 2

| 2

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➶

reach

"As shown in XREF_FIG, MDA and 4-HNE significantly reduced TLR7 and its downstream signaling pathway to LC3A/B."

27279075

---

➶

reach

"MDA and 4-HNE serve as the second hit to disrupt TLR7, which appears to be involved in a feedback system."

27279075

MTOR inhibitor affects RELA

| 2

MTOR inhibitor inhibits RELA. 2 / 2

| 2

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➶

sparser

"In this study, immunoblotting experiments revealed that the level of constitutively expressed phospho p65 ( xref ), TNFα- induced phospho p65 ( xref ) were inhibited by the mTOR inhibitors."

26940200

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➶

sparser

"In this study, immunoblotting experiments revealed that the level of constitutively expressed phospho p65 ( xref ), TNFα- induced phospho p65 ( xref ) were inhibited by the mTOR inhibitors."

26940200

Luteolin affects JUN

1 | 1

Luteolin inhibits JUN. 2 / 2

1 | 1

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➶

reach

"Moreover, IL-1beta-induced activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) activation were inhibited by luteolin."

20600535

---

➶

ctd

No evidence text available

16343431

Luteolin 7-O-beta-D-glucoside affects CASP1

| 2

Luteolin 7-O-beta-D-glucoside inhibits CASP1. 2 / 2

| 2

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➶

reach

"Inactivation of caspase-1 by luteoloside resulted in inhibition of IL-1beta."

24587153

---

➶

reach

"The results from this experiment suggests that luteoloside decreases the proteolytic cleavage of pro-caspase-1 in both Huh-7 and SMMC-7721 HCC cells in a dose dependent fashion compared with non treated control cells (XREF_FIG, line 2; 4C)."

24587153

Lupeol affects JAK1

| 2

Lupeol inhibits JAK1. 2 / 2

| 2

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➶

reach

"We found that IL-6-induced STAT3, JAK1 and JAK2 activation was also suppressed by lupeol in HCC cells."

25101566

---

➶

reach

"Lupeol suppresses constitutive activation of JAK1 and JAK2."

25101566

Losartan affects STAT1

| 2

Losartan inhibits STAT1. 2 / 2

| 2

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➶

reach

"Losartan inhibits STAT1 activation and protects human glomerular mesangial cells from angiotensin II induced premature senescence."

22217266

---

➶

reach

"Our results indicate that STAT1 is implicated in the mediation of Ang II induced HMC senescence through p53 / p21 (Cip1) pathway, and that losartan could attenuate HMC senescence by regulating STAT1."

22217266

Lithium(1+) affects TBK1

| 2

Lithium(1+) inhibits TBK1. 2 / 2

| 2

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➶

reach

"Lithium attenuates IFN-beta production and antiviral response via inhibition of TANK binding kinase 1 kinase activity."

24043902

---

➶

reach

"In vitro kinase assay demonstrates that lithium suppresses TANK binding kinase 1 kinase activity."

24043902

Lithium(1+) affects IFNB1

| 2

Lithium(1+) inhibits IFNB1. 2 / 2

| 2

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➶

reach

"Lithium attenuates IFN-beta production and antiviral response via inhibition of TANK binding kinase 1 kinase activity."

24043902

---

➶

reach

"The ability of the lithium to inhibit IFN-beta production was confirmed in vivo, as mice treated with lithium chloride exhibited decreased levels of IFN-beta upon Sendai virus infection."

24043902

Lipoxin A4 affects TRAF6

| 2

Lipoxin A4 inhibits TRAF6. 2 / 2

| 2

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➶

reach

"LXA4 significantly inhibited the mRNA and protein expression levels of TNF-alpha, IL-1beta and TRAF6 induced by LPS in NHEKs, and LXA4 obviously increased the expression of SOCS2 at mRNA and protein levels."

26072084

---

➶

reach

"Lipoxin A4 inhibits lipopolysaccharide induced production of inflammatory cytokines in keratinocytes by up-regulating SOCS2 and down-regulating TRAF6."

26072084

Lipopolysaccharide affects PYCARD

| 2

Lipopolysaccharide inhibits PYCARD. 2 / 2

| 2

---

➶

reach

"Pretreatment of LPS primed THP-1 cells with b-AP15 significantly reduced the numbers of ASC specks formed after nigericin treatment (XREF_FIG, A and C)."

23209292

---

➶

reach

"The infection of the anti-B-cell receptor, lipopolysaccharide, or CpG stimulated CBC reduced the secretion of IL-6 and IL-8 and decreased the number of ASC."

20164228

Lipopolysaccharide affects ITCH

| 2

Lipopolysaccharide inhibits ITCH. 2 / 2

| 2

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➶

reach

"Interestingly, intrathecal LPS suppressed compound 48/80 and CQ induced acute itch (XREF_FIG), but enhanced compound 48/80 induced alloknesis (XREF_FIG)."

26645545

---

➶

reach

"Intrathecal LPS enhances acute pain, alloknesis, and chronic itch but suppresses acute itch."

26645545

Limonene affects MAPK14

| 2

Limonene inhibits MAPK14. 2 / 2

| 2

---

➶

medscan

"Our findings show that H2O2-induced apoptosis is mainly mediated through the activation of p38 mitogen-activated protein kinase and that D-limonene inhibits the phosphorylation of p38 mitogen-activated protein kinase ( )."

26682012

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➶

medscan

"We found that D-limonene inhibits the H2O2-stimulated activation of the p38 mitogen-activated protein kinase signaling pathway, and thus, it may be an effective natural drug for the treatment of cataracts due to its effects on ameliorating oxidative damage to HLECs."

26682012

Levamisole affects IFNB1

| 2

Levamisole inhibits IFNB1. 2 / 2

| 2

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➶

sparser

"A possible explanation for the ability of levamisole to prevent suppression by these agents may be that levamisole inactivates IFNP, SIRS or M6-SF."

6341267

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➶

sparser

"Effect of adding levamisole at different times during the culture period These experiments indicated that levamisole did not inactivate IFNP, SIRS of M6-SF."

6341267

Leptomycin B affects STAT1

| 1 1

Leptomycin B inhibits STAT1. 2 / 2

| 1 1

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➶

medscan

"These results show that leptomycin B reduces the constitutive nuclear export of Stat1 in unstimulated cells."

15210729

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➶

reach

"Indeed P1 alone can cause the cytoplasmic retention of STAT1, and treatment of cells with leptomycin B reverses or inhibits cytoplasmic sequestration of STAT1 [122]."

26198243

Lapatinib affects MAPK8

| 1 1

Lapatinib inhibits MAPK8. 2 / 2

| 1 1

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➶

reach

"JNK1 knockdown, and to a lesser extent compound JNK1 and JNK2 knockdown, significantly rescued cell viability when treated with JNK-IN-8 and lapatinib combination."

29285221

---

➶

eidos

"In addition , lapatinib successfully prevented activation of the EGFR-RAF-MEK1 / 2-ERK1 / 2 pathway in Jnk1 / 2 mice ."

32490320

Lapatinib affects JUN

| 2

Lapatinib inhibits JUN. 2 / 2

| 2

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➶

reach

"Taken together, the present study provided the first evidences that miR-1470 mediated lapatinib induced p27 upregulation by targeting c-jun."

25545366

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➶

reach

"Although Nie et al demonstrated that miR-1470 mediated lapatinib induced p27 up-regulation by targeting c-jun, the expression status, role and underlying molecular oncogenic mechanism of miR-1470 in esophageal cancer progression remain to be established."

29344220

Lactate affects NLRP3

| 2

Lactate inhibits NLRP3. 2 / 2

| 2

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➶

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"In macrophages and monocytes, increasing concentrations of lactate reduced TLR4 mediated induction of Il1B, Nlrp3, and Casp1; activation of NFkappaB; release of IL1beta; and cleavage of CASP1."

24657625

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➶

reach

"Invitro experiments, by isolating the pancreatic acinar cells (PACs) from mice, we found that Indo significantly reduced lactate dehydrogenase (LDH) excretion, increased the cell activity, and inhibited the NLRP3 inflammasome pathway of PACs."

28867183

Lactate affects IFIH1

| 1 1

Lactate inhibits IFIH1. 2 / 2

| 1 1

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➶

eidos

"Lactate and hexokinase have also recently been found to inhibit RIG-I and MDA5 by interacting with MAVS , which may be significant in explaining the interplay between metabolism and immune signaling as glycolysis was found to be greatly decreased upon RLR signaling ( 329 ) ."

31379819

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➶

reach

"Lactate and hexokinase have also recently been found to inhibit RIG-I and MDA5 by interacting with MAVS, which may be significant in explaining the interplay between metabolism and immune signaling as glycolysis was found to be greatly decreased upon RLR signaling (329)."

31379819

Lactate affects CASP1

| 2

Lactate inhibits CASP1. 2 / 2

| 2

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➶

reach

"XREF_BIBR, XREF_BIBR The reduction in TLR induced Pro Il1beta and inflammasome components Nlrp3 and Casp1 by lactate predicts that lactate would also reduce CASP1 activity, and IL1beta release, which is the case (XREF_FIG)."

24657625

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➶

reach

"In macrophages and monocytes, increasing concentrations of lactate reduced TLR4 mediated induction of Il1B, Nlrp3, and Casp1; activation of NFkappaB; release of IL1beta; and cleavage of CASP1."

24657625

Ketamine affects JUN

| 2

Ketamine inhibits JUN. 2 / 2

| 2

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➶

reach

"Ketamine up-regulated heme-oxygenase-1 and attenuated lipopolysacharide induced changes in gastric nuclear factor-kappass, activator protein-1, and inducible nitric oxide synthase."

16927154

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➶

reach

"In conjunction with the last cited study, also using electrophoretic mobility shift assays, ketamine inhibited NFkB and another pro inflammatory transcription factor, activator protein 1 (AP-1) in human neutrophils and a leukocyte like transformed cell line, which was not dependent on activation of NMDA or opioid receptors."

24318540

Kaempferol affects NLRP3

| 2

Kaempferol inhibits NLRP3. 2 / 2

| 2

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➶

eidos

"88 In contrast , kaempferol decreases NLRP3 expression by regulating the autophagy pathway ."

| PMC

---

➶

eidos

"In addition , withaferin A and kaempferol inhibit NLRP3 via indirect mechanisms ."

| PMC

Kaempferol oxoanion affects TYK2

| 2

Kaempferol oxoanion inhibits TYK2. 2 / 2

| 2

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➶

reach

"However, the FITC green fluorescence disappeared in lung tissues by supplying kaempferol to OVA challenged mice at the dosages of 10 and 20mg/kg (XREF_FIG), indicating that kaempferol diminished airway inflammation by deterring the Tyk2 activation."

23737822

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➶

reach

"LPS activated Tyk2 responsible for eotaxin-1 induction, while kaempferol dose-dependently inhibited LPS- or IL-8-inflamed Tyk2 activation."

23737822

Isotretinoin affects RELA

2 |

Isotretinoin inhibits RELA. 2 / 2

2 |

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➶

ctd

No evidence text available

19066126

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➶

ctd

No evidence text available

18652567

Isotretinoin affects NFKB1

2 |

Isotretinoin inhibits NFKB1. 2 / 2

2 |

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➶

ctd

No evidence text available

18652567

---

➶

ctd

No evidence text available

19066126

Isoflurane affects NLRP3

| 2

Isoflurane inhibits NLRP3. 2 / 2

| 2

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reach

"Anesthetic isoflurane inhibits the NLRP3 inflammasome in the MRL and lpr SLE mouse model [XREF_BIBR]."

28374568

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➶

reach

"In addition, Li et al. demonstrated that A20, a TNF induced protein 3 (TNFAIP3) known as a negative modulator of inflammation, markedly suppressed the activation of NLRP3 inflammasome and mitigated LN symptoms in pristine induced lupus mice [XREF_BIBR], and Yuan et al. reported that isoflurane abrogated the formation and activation of renal NLRP3 inflammasome and ameliorated renal dysfunction and injury in MRL and lpr lupus mice [XREF_BIBR]."

29302207

Isoflavone affects RELA

| 2

Isoflavone inhibits RELA. 2 / 2

| 2

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sparser

"Soy Isoflavones Inhibit Radiation-Induced NF-κB p65 in Lung Tissue."

28168165

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➶

sparser

"Soy Isoflavones Inhibit Radiation-Induced NF-κB p65 in Lung Tissue."

28168165

Isocyanic acid affects JUN

| 2

Isocyanic acid inhibits JUN. 2 / 2

| 2

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➶

reach

"In contrast to our finding that ICA inhibited c-Jun activation including decreased protein expression and GR binding, previous studies showed that c-Jun may be activated by ICA [40, 41]."

29317219

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➶

reach

"In addition, ICA intervention inhibited the up-regulation of NF-kappaB p65, Stat3, and c-Jun and down-regulation of IkappaBalpha in the inflammatory cell models."

29317219

Indole-3-methanol affects NFKB1

2 |

Indole-3-methanol inhibits NFKB1. 2 / 2

2 |

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ctd

No evidence text available

15811958

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➶

ctd

No evidence text available

16082211

Imatinib affects NFKB1

| 2

Imatinib inhibits NFKB1. 2 / 2

| 2

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reach

"According to these findings it was suggested that the decreased miR-146a expression observed in untreated CML cells could contribute to mediate the BCR and ABL induced NFkB constitutive activation; on the other hand, the increased miR-146a expression observed following imatinib treatment, could contribute to mediate the imatinib induced NFkB inhibition [XREF_BIBR]."

22453030

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➶

reach

"Imatinib treatment inhibit IL-6, IL-8, NF-KB and AP-1 production and modulate intracellular calcium in CML patients."

21938724

Ibuprofen affects RELA

1 | 1

Ibuprofen inhibits RELA. 2 / 2

1 | 1

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➶

reach

"CSP-1103, but not ibuprofen, reduced the immunoreactivity of the RelA subunit in nuclear extracts, suggesting a reduced nuclear translocation (XREF_FIG A, B)."

28106772

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➶

ctd

No evidence text available

10602496

Hydroxychloroquine affects STING1

| 2

Hydroxychloroquine inhibits STING1. 2 / 2

| 2

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reach

"Induction of cytokine expression resulting from innate immune signaling is also impacted by HCQ mediated reduction in DNA/RNA binding and activation of cGAS/STING signaling and altered endosomal pH also disrupts binding to TLR7/9."

32350928

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➶

reach

"It is important to note that MyD88‐dependent signaling is not impacted by CQ, though it can be modulated by SARS‐CoV and is necessary for the protection in a murine challenge model.59 Furthermore, HCQ inhibits cyclic GMP‐AMP synthase (cGAS) activity in host cells.60 Activation of the cGAS/STING pathway by RNA/DNA‐dependent mechanism promotes increased type I interferon (IFNβ) production."

32350928

Hydrogen peroxide affects NFKBIA

| 1 1

Hydrogen peroxide inhibits NFKBIA. 2 / 2

| 1 1

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➶

reach

"Catalase 1 kU/ml inhibited NF-kappaB activation by TNF-alpha; exogenous hydrogen peroxide 200 microM activated NF-kappaB and stimulated I-kappaBalpha degradation."

9657527

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➶

eidos

"Oxidative stress , via its formation of H2O2 , which enhances degradation of IkappaBalpha , enhances NF-kappaB activity [ 22b ] ; thus , macrophages have increased production of cyclooxygenase 2 ( Cox-2 ) , prostaglandin E2 ( PGE2 ) , and matrix metalloproteinase 1 ( MMP-1 ) [ 45 ] ."

| PMC

Hydrogen peroxide affects NFKB1

| 1 1

Hydrogen peroxide inhibits NFKB1. 2 / 2

| 1 1

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medscan

"Furthermore, suppression of Toll-like receptor 9 (TLR9), a specific receptor of bacterial DNA, expression by RNAi abolished the decrease of H(2)O(2)-induced IL-8 secretion and inhibition of H(2)O(2)-induced NF-κB/IκB-α system activation by Lactic acid bacteria genomic DNA."

23182970

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reach

"Because ROS inhibitors can inhibit NF-KB activation induced by TNF and phorbol myristate acetate (PMA) as well as by hydrogen peroxide, it has been proposed that ROS production might be an essential step leading to NF-KB activation "."

9695819

Hydrogen chloride affects NLRP3

| 2

Hydrogen chloride inhibits NLRP3. 2 / 2

| 2

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"Since then, studies have demonstrated that Cl - channel inhibitors, including flufenamic acid, IAA94, DIDS, and NPPB, may inhibit NLRP3, but not AIM2 or NLRC4 inflammasome activation XREF_BIBR - XREF_BIBR."

30755589

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➶

reach

"In this study, by searching for kinds of lysine acetyltransferases inhibitors, we showed that SI-2 hydrochloride (SI-2), a specific inhibitor of lysine acetyltransferase KAT13B (lysine acetyltransferases 13B), specifically blocks NLRP3 inflammasome activation both in mice in vivo and in human cells ex vivo."

32736194

Hyaluronic acid affects MAPK14

| 2

Hyaluronic acid inhibits MAPK14. 2 / 2

| 2

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➶

medscan

"Hyaluronan inhibits p38 mitogen-activated protein kinase via the receptors in rheumatoid arthritis chondrocytes stimulated with fibronectin fragment."

20552237

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➶

medscan

"Our study clearly shows that hyaluronan inhibits IL-1β-induced MMP-13 via its principal receptor, CD44, and subsequent intracellular p38 Mitogen-activated protein kinase signaling in osteoarthritis and rheumatoid arthritis chondrocytes."

20706991

Homocysteine affects CASP1

| 2

Homocysteine inhibits CASP1. 2 / 2

| 2

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"Finally, homocysteine induced DNA fragmentation was reversed in caspase-1 (-/-) EC."

27006445

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➶

reach

"Finally, Hcy induced DNA fragmentation was reversed in caspase-1 -/- EC."

27006445

Hexadecanoic acid affects TICAM1

| 2

Hexadecanoic acid inhibits TICAM1. 2 / 2

| 2

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reach

"However, palmitate treatment did not induce degradation of MyD88 and TRIF, even in Cbl-b +/+ peritoneal macrophages (XREF_FIG)."

23349502

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➶

reach

"We found that palmitate treatment did not induce degradation of MyD88 and TRIF even in Cbl-b +/+ peritoneal macrophages."

23349502

Hexadecanoic acid affects NLRP3

| 2

Hexadecanoic acid inhibits NLRP3. 2 / 2

| 2

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"RIPK2 ablation, palmitate treatment, and mevalonate kinase-deficiency also reduce autophagy and mitophagy, increase mtROS, and enhance NLRP3 activation."

25879282

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➶

reach

"In vitro, nebivolol treatment of palmitate incubated H9C2 cells suppressed autophagy, restored mitochondrial biogenesis, leading to decreased mitochondrial reactive oxygen species (mtROS) generation, and suppressed NLRP3 inflammasome activation."

27686325

Hexadecanoic acid affects CASP1

| 2

Hexadecanoic acid inhibits CASP1. 2 / 2

| 2

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reach

"Consistent with these previous studies, our data demonstrate that palmitate induced caspase-1 activity and IL-1beta production were blocked by cathepsin B inhibitor Ca-074Me."

27689324

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➶

reach

"Palmitate induced degradation of pro-caspase-1 to caspase-1 (p10) as well as cleavage of pro-IL-1beta to mature IL-1beta in primary mouse hepatocytes, as determined by immunoblotting of caspase-1 (p10) and IL-1beta in cell supernatants (XREF_FIG)."

27075683

Hexadecane affects PYCARD

| 2

Hexadecane inhibits PYCARD. 2 / 2

| 2

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"Irradiation of CNS effector cells reduced CpG and R848 ASC frequencies back to feeder only culture frequencies (XREF_FIG)."

28495370

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➶

reach

"Irradiation of CNS effector cells reduced CpG and R848 ASC frequencies back to feeder only culture frequencies (Fig. 4A)."

28495370

Hexadecane affects ITCH

| 2

Hexadecane inhibits ITCH. 2 / 2

| 2

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reach

"Together, these observations are consistent with the idea that nociceptors excited by counter-stimuli engage mechanisms within the CNS to block the transmission of itch."

21056479

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➶

reach

"Thus, increasing 5-HT level in CNS suppressed itch and induced antinociception in sham and BDL rats."

27824106

Herbimycin affects STAT1

1 | 1

Herbimycin inhibits STAT1. 2 / 2

1 | 1

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"Herbimycin A, a specific tyrosine kinase inhibitor [25] which potently inhibits iNOS induction stimulated by IFN-gamma and LPS in C6 cells [8], abolished IFN-gamma-induced DNA binding of Stat1 to GRR GAS in a dose dependent fashion."

9180263

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ctd

No evidence text available

10825233

Heme affects EIF2AK1

| 2

Heme inhibits EIF2AK1. 2 / 2

| 2

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sparser

"Alternatively, the inactivation of HRI by continuously synthesized heme positively induced the translation of HO-1 mRNA."

28347842

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sparser

"PERK is activated by endoplasmic reticulum (ER) stress [ xref ], and HRI is inhibited by heme [ xref , xref ]."

24714526

Glyburide affects PYCARD

| 2

Glyburide inhibits PYCARD. 2 / 2

| 2

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"Consistently, glibenclamide also blocked the oligomerization of ASC (XREF_FIG) and the association of NLRP3 and ASC (XREF_FIG and XREF_SUPPLEMENTARY) in mouse BMDMs in response to 25-HC treatment."

27779191

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➶

reach

"In agreement with the effects seen previously on IL-1beta secretion and caspase-1 activation glyburide and parthenolide did not inhibit AIM2 dependent ASC oligomerisation."

22216309

Glutathione affects RELA

| 2

Glutathione inhibits RELA. 2 / 2

| 2

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reach

"In addition, physalin F suppressed NF-kappaB activity and nuclear translocation of p65 and p50, which was reversed by NAC and GSH."

22815798

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➶

reach

"In addition, physalin F abrogated the nuclear translocation of p65 and p50 subunits that were reversed by both ROS scavengers, NAC and GSH (XREF_FIG)."

22815798

Glutathione affects NFKBIA

| 2

Glutathione inhibits NFKBIA. 2 / 2

| 2

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"PL increased ROS (measured by DCFH-DA), reduced glutathione, activated p38 and JNK, increased IkappaBalpha, and suppressed NFkappaB in LN229 cells after scratching."

24967005

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➶

reach

"We show that in contrast to wt mice, GSH depleted mouse livers have persistent hepatic IkappaBalpha at 30 minutes after TNF-alpha injection, indicating that proteasomal degradation of IkappaBalpha is delayed and is possibly responsible for the inhibition of NFkappaB activation in these animals."

24611135

Glutathione affects JAK1

| 2

Glutathione inhibits JAK1. 2 / 2

| 2

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"We assessed whether GSH depletion inhibits JAK1 activation induced by LIF, which is the initiating step in IL-6-type cytokine signaling."

22939972

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➶

reach

"Therefore, the present study was undertaken to directly test the hypothesis that JAK1 signaling by the IL-6-type cytokines in cardiac myocytes is impaired by glutathione (GSH) depletion, since this tripeptide is one of the major anti-oxidant molecules and redox-buffers in cells."

22939972

Glucose affects TRAF6

| 2

Glucose inhibits TRAF6. 2 / 2

| 2

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reach

"In contrast, sildenafil significantly reversed high glucose reduced miR-146a levels and high glucose increased IRAK1 and TRAF6."

27167084

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➶

reach

"In addition, axonal application of sildenafil reversed HG reduced miR-146a levels (XREF_FIG) and their target gene, IRAK1 (XREF_FIG) and TRAF6 (XREF_FIG) mRNAs (XREF_FIG) and proteins (XREF_FIG) in the distal axons."

27167084

Glucose affects TBK1

| 2

Glucose inhibits TBK1. 2 / 2

| 2

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reach

"Both sodium azide and glucose starvation activated NF-kappaB and TBK1 associated innate immune response."

31736938

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➶

reach

"In glucose starved cells, the exocyst but not TBK1 coimmunoprecipitated with AKT."

21329883

Glucose affects RIPK1

| 2

Glucose inhibits RIPK1. 2 / 2

| 2

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reach

"Supplementation of glucose diminished the RIP dependent LDH leakage and morphological damage in hypoxic cells, whereas non metabolizable sugar analogs did not."

23640464

---

➶

reach

"Glucose uptake abolishes Hx induced RIP signaling and necroptosis."

23640464

Glucocorticoid affects TBK1

| 2

Glucocorticoid inhibits TBK1. 2 / 2

| 2

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reach

"SHP-2, resveratrol isoliquiritigenin and glucocorticoid inhibit TBK1 kinase activity."

23395611

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➶

reach

"Additionally, glucocorticoid dexamethasone could attenuate TBK1 activity through suppress its kinase activity, in addition to inhibiting its phosphorylation [47] ."

23395611

Glipizide affects NLRP3

| 2

Glipizide inhibits NLRP3. 2 / 2

| 2

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➶

reach

"As evidence showed that another sulfonylurea drug glipizide also inhibited Sur1 containing K ATP channels but failed to inhibit NLRP3 inflammasome activation."

28740332

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➶

reach

"The specific effect of glyburide was confirmed by showing that glipizide, which is structurally similar to glyburide but does not inhibit NLRP3, did not affect the ability of M. tuberculosis to induce IL-1beta production (XREF_FIG) or necrosis (data not shown)."

21740493

Ginsenoside Rb1 affects NFKBIA

| 2

Ginsenoside Rb1 inhibits NFKBIA. 2 / 2

| 2

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reach

"Ginsenoside Rb1 could decrease the COX-2 positive cells and IkB-alpha positive cells and increase the nNOS positive cells in hippocampus compared to model group."

29854792

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➶

reach

"Ginsenoside Rb1 reduced the number of COX-2-positive cells and positive IkB-alpha cells and increased the number of nNOS positive cells in the hippocampus, as compared to the model group."

30816465

Ginsenoside Rb1 affects IKBKB

| 2

Ginsenoside Rb1 inhibits IKBKB. 2 / 2

| 2

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"Ginsenoside Rb1 and its metabolite compound inhibited the activation of key inflammatory mediators IRAK-1 (interleukin-1 receptor associated kinase-1), IKK-beta (inhibitor of NF-kappabeta kinase), NF-kappabeta, and MAPK (mitogen activated protein kinases) while suppressing colitis [XREF_BIBR]."

22899889

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➶

reach

"Ginsenoside Rb1 and compound K also significantly inhibited the activation of interleukin-1 receptor associated kinase-1 (IRAK-1), IKK-beta, NF-kappaB, and MAP kinases (ERK, JNK, and p-38); however, interaction between LPS and Toll like receptor-4, IRAK-4 activation and IRAK-2 activation were unaffected."

21600888

Genistein affects NLRP3

| 2

Genistein inhibits NLRP3. 2 / 2

| 2

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➶

reach

"Genistein protects against DSS induced colitis by inhibiting NLRP3 inflammasome via TGR5-cAMP signaling."

30901677

---

➶

reach

"In conclusion, our study unveils that Genistein was able to inhibit NLRP3 inflammasome via TGR5-cAMP signaling in macrophages."

30901677

Genistein affects NFKB1

| 2

Genistein inhibits NFKB1. 2 / 2

| 2

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➶

reach

"In addition, genistein was demonstrated to prevent activation of the redox sensitive transcription factor NF-KB in cancer cells in vitro and in human blood lymphocytes (Davis et al., 2001)."

18541232

---

➶

reach

"Genistein is known to inhibit NFkB activation, one of the major activators of the inflammatory response, and it has antioxidant activity."

21675818

Genistein affects MAPK14

| 2

Genistein inhibits MAPK14. 2 / 2

| 2

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➶

medscan

"Moreover, inhibition of ERK1/2 activity enhanced cell growth inhibition by genistein, whereas inhibition of p38 mitogen-activated protein kinase activity rescued from genistein-mediated growth inhibition."

19723095

---

➶

medscan

"Genistein blocks activation of p38 mitogen-activated protein kinase and thus inhibits matrix metalloproteinase-2 (MMP-2) expression and cell invasion in cultured cells and inhibits metastasis of human prostate cancer cells in mice."

19638505

Ganetespib affects RIPK1

| 2

Ganetespib inhibits RIPK1. 2 / 2

| 2

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➶

reach

"Interestingly, we showed that doxorubicin upregulated whereas ganetespib downregulated RIP1 in both H82 and GLC4 cells by western blot analysis (XREF_FIG)."

24166505

---

➶

reach

"How the downregulation of RIP1 by ganetespib may play a role in doxorubicin sensitization will require additional investigation."

24166505

Gallic acid affects JAK1

| 2

Gallic acid inhibits JAK1. 2 / 2

| 2

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➶

reach

"GA Suppresses the Constitutive Activation of JAK1 and JAK2."

21490133

---

➶

reach

"We found that GA inhibited c-Src, JAK1, and JAK2 activation."

21490133

Gallic acid affects IKBKB

| 2

Gallic acid inhibits IKBKB. 2 / 2

| 2

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➶

reach

"Inhibition of IKKbeta Activity by GA in vitro."

19140805

---

➶

reach

"In fact, GA blocked biogenesis of IKKalpha and IKKbeta but did not interfere with post-translational turnover."

15077173

Gallic acid affects CHUK

1 | 1

Gallic acid inhibits CHUK. 2 / 2

1 | 1

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➶

ctd

No evidence text available

22387266

---

➶

reach

"In fact, GA blocked biogenesis of IKKalpha and IKKbeta but did not interfere with post-translational turnover."

15077173

Furosemide affects ITCH

| 2

Furosemide inhibits ITCH. 2 / 2

| 2

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"In human skin, bumetanide and furosemide, both of which block NKCC1, inhibit itch and flare responses to histamine."

19167425

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➶

reach

"In study 1, nedocromil sodium, frusemide and bumetanide reduced itch scores by 36%, 48% and 34%, respectively, and flare areas by 17%, 26% and 15% respectively (all P < 0.05)."

15005740

Formononetin affects NLRP3

| 2

Formononetin inhibits NLRP3. 2 / 2

| 2

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➶

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"Formononetin Inhibited NLRP3 Pathway in Mice Colonic Epithelial Cells."

29507526

---

➶

reach

"In this study, by using immunohistochemical staining, we firstly detected that the expression of NLRP3 in colonic tissue was elevated in DSS induced colitis and formononetin reduced the activation of NLRP3 pathway (XREF_FIG)."

29507526

Flufenamic acid affects NLRP3

| 2

Flufenamic acid inhibits NLRP3. 2 / 2

| 2

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"Flufenamic acid and mefenamic acid inhibit NLRP3 inflammasome activation through the suppression of chloride efflux."

29021150

---

➶

reach

"A few NLRP3 inflammasome inhibitors, including sulforaphane, isoliquiritigenin, beta-hydroxybutyrate (BHB), flufenamic acid, mefenamic acid, 3,4-methylenedioxy-beta-nitrostyrene (MNS), parthenolide, BAY 11-7082, INF39, and MCC950, have been developed, but there is no evidence showing that these compounds can specifically and directly inhibit NLRP3 itself."

29021150

Flavonoid affects CASP1

| 2

Flavonoid inhibits CASP1. 2 / 2

| 2

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sparser

"Here we show through Michaelis-Menten kinetic analysis that myricetin as well other flavonoids are able to inhibit caspase-1, −3, or −7 activity in vitro and that the inhibition is competitive."

22140296

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➶

sparser

"In conclusion, our results show that some natural flavonoids are able to inhibit caspase-1, −3, and −7 activity."

22140296

Fingolimod hydrochloride affects PYCARD

| 2

Fingolimod hydrochloride inhibits PYCARD. 2 / 2

| 2

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➶

reach

"We show that FTY720 treatment inhibits IgG ASC egress from spleen and LNs."

17101733

---

➶

reach

"FTY720 treatment inhibits IgG ASC entry into blood and homing to BM."

17101733

Fingolimod hydrochloride affects NLRP3

| 2

Fingolimod hydrochloride inhibits NLRP3. 2 / 2

| 2

---

➶

reach

"The functional S1PR1 antagonist FTY720 blocked NLRP3 activation and IL-1beta production."

30802544

---

➶

reach

"The functional S1PR1 antagonist FTY720 blocked NLRP3 activation and IL-1beta production."

30802544

Fenofibrate affects NFKB1

| 2

Fenofibrate inhibits NFKB1. 2 / 2

| 2

---

➶

reach

"Fenofibrate downregulated p-IKKa/b, p-IkappaBa, and nuclear NFkappaB (p65 and p50), which are involved in the NF-kappaB pathway, and upregulated AMPK related proteins, such as LKB1, p-AMPKalpha, p-AMPKbeta1, and AMPKgamma1."

29760790

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➶

reach

"XREF_TABLE and XREF_FIG showed that fenofibrate could significantly inhibit the up-regulation of NF-kappaB p50 and p65 proteins of EAM rats (p < 0.05)."

27095924

Exalamide affects NLRP3

| 2

Exalamide inhibits NLRP3. 2 / 2

| 2

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reach

"Youm et al. [XREF_BIBR] reported HBA specifically inhibits NLRP3 inflammasome activation and decreases the production of active IL-1beta and IL-18."

28273882

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➶

reach

"Ketone body beta-hydroxybutyric acid (HBA) has a similar chemical structure as NaB and was also reported to inhibit NLRP3 activation [XREF_BIBR], and has been shown to decrease apoptosis of rat corneal epithelia in dry eye conditions [XREF_BIBR]."

28273882

Ethyl methanesulfonate affects RELA

| 2

Ethyl methanesulfonate inhibits RELA. 2 / 2

| 2

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➶

reach

"Moreover, EMS reduced the level of nuclear p65 protein in HDFs."

25761492

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➶

reach

"Third, we also found that the total and nuclear protein level of p65, which is subunit of NF-kappaB [XREF_BIBR], was increased by TNF-alpha stimulation and the increased p65 protein was largely decreased by EMS pretreated HDFs, indicating that TNF-alpha-induced NF-kappaB nuclear translocation was inhibited by EMS treatment in HDFs."

25761492

Ethyl methanesulfonate affects PYCARD

| 2

Ethyl methanesulfonate inhibits PYCARD. 2 / 2

| 2

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reach

"However, the prolonged inflammation and insulin resistance of EMS horses, in particular over expression of pro inflammatory cytokines, might drastically reduce ASC stemness and their anabolic activity, which is recognized as a regenerative potential [XREF_BIBR, XREF_BIBR]."

29292726

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➶

reach

"However, EMS impairs ASC 's self-renewal and differentiation properties."

27629697

Ethanol affects STING1

| 2

Ethanol inhibits STING1. 2 / 2

| 2

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➶

reach

"Several elders noted that application of rubbing alcohol reduced the itch or sting associated with the bug bite, or made their irritated skin feel better generally."

26543255

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➶

reach

"Notably, 70% ethanol extract of Cephalotaxus koreana specifically down-regulated STING induced, but not TBK1- or IRF3 induced, IFN-beta promoter activity."

28771599

Ethanol affects MYD88

| 2

Ethanol inhibits MYD88. 2 / 2

| 2

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➶

reach

"Here, we show that cellular stress proteins HSF1 and hsp70 play a mechanistic role in alcohol mediated inhibition of the TLR4 and MyD88 pathway."

25024384

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➶

reach

"In this study, we show that cellular stress proteins HSF1 and hsp70 play a mechanistic role in alcohol mediated inhibition of the TLR4 and MyD88 pathway."

25024384

Estrogen affects FOS

| 2

Estrogen inhibits FOS. 2 / 2

| 2

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➶

reach

"A preventive effect was demonstrated by using Juzen-taiho-to on endometrial carcinogenesis via the suppression of estrogen induced c-fos and jun-expression that created an inhibitory effect on E2 related endometrial carcinogenesis in mice."

26300773

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➶

reach

"First, estrogen is implied to decrease the osteoclastic resorption pit in bone by regulating several transcription factors (c-fos, c-jun, e.g.) and inflammatory cytokines (IL-1RI, IL-1RII, e.g.) [XREF_BIBR]."

22135675

Ent-crizotinib affects IKBKE

2 |

Ent-crizotinib inhibits IKBKE. 2 / 2

2 |

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➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

Empagliflozin affects NLRP3

| 2

Empagliflozin inhibits NLRP3. 2 / 2

| 2

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reach

"Of note, empagliflozin attenuated activation of the NLRP3 inflammasome and expression of associated markers of sterile inflammation in hearts from mice with HFrEF, implicating reduced cardiac inflammation as a mechanism of empagliflozin that contributes to sustained function in HFrEF in the absence of diabetes mellitus."

31957470

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➶

reach

"71 Metformin and empagliflozin, two well-known antidiabetic drugs, inhibited NLRP3 inflammasome and decelerated the development of diabetic cardiomyopathy but via different mechanisms."

| PMC

Emodin affects NFKBIA

| 2

Emodin inhibits NFKBIA. 2 / 2

| 2

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reach

"Additionally, emodin suppressed the accumulation of p-IkappaBalpha and NF-kappaB, while stimulating the Nrf2-antioxidant signaling process in damaged lungs."

29290631

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➶

reach

"XREF_BIBR Our data showed that emodin treatment inhibited the activation of NF-kappaB and promoted the degradation of IkappaBalpha."

32546964

Emetine affects IKBKB

| 2

Emetine inhibits IKBKB. 2 / 2

| 2

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reach

"We have further dissected the pathway and found that Emetine is an efficient inhibitor of the IKK-beta that result in the phosphorylation of IkappaB-alpha and NFkappaB degradation 17."

29391537

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➶

reach

"Surprisingly, Emetine downregulated IKK-beta, but not IKK-alpha, subunit protein."

27682876

Ellagic acid affects JUN

| 2

Ellagic acid inhibits JUN. 2 / 2

| 2

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reach

"Treatment with dexamethasone, but not ellagic acid, decreased the activation of p65 NF-kappaB and c-Jun compared with the vehicle treated mice."

23533300

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➶

reach

"Ellagic acid inhibited IL-1beta- and TNF-alpha-induced activation of activator protein-1 and mitogen activated protein kinases (extracellular signal regulated kinase, c-Jun N-terminal kinase and p38 mitogen activated protein kinase), but not of nuclear factor-kappaB."

16023081

Ecgonine benzoate affects NFKBIA

| 2

Ecgonine benzoate inhibits NFKBIA. 2 / 2

| 2

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reach

"From our present results, treatment of cells with LY294002 and wortmannin attenuated M. bovis BCG induced IkappaBalpha degradation."

19181310

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reach

"As shown in Fig. 6, treatment of cells with LY294002 and wortmannin attenuated M. bovis BCG induced IkappaBalpha degradation."

19181310

Ecgonine benzoate affects CASP1

| 2

Ecgonine benzoate inhibits CASP1. 2 / 2

| 2

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reach

"BCG infection also prevents the activation of caspase-1 triggered by the simultaneous administration of NLRP3 inflammasome agonists nigericin and ATP."

20638636

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➶

reach

"Another report showed that M. bovis BCG, the vaccine strain of Mtb, can limit caspase-1 and IL-1beta activation due to a putative protease Zmp1."

20808838

Doxycycline affects MAP3K7

| 2

Doxycycline inhibits MAP3K7. 2 / 2

| 2

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"To study the effect of TAK1 knockdown on acute inflammation, adult TAK1-Tg mice were treated with doxycycline for five weeks and inflammation was induced by intraperitoneal injection of LPS."

23505428

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➶

reach

"Mice in which both TAK1 and IL1 signaling were blocked by the administration of both doxycycline and anakinra showed significantly lower metastatic burden than mice that received a single treatment."

29777109

Doxorubicin affects IKBKB

| 2

Doxorubicin inhibits IKBKB. 2 / 2

| 2

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"Recently, it has also been shown that doxorubicin can initiate IkappaBalpha degradation and NF-kappaB activation independent of either IKKalpha or IKKbeta using the same in vitro models."

18644995

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➶

reach

"Having identified that IKKalpha has a dominant role in NF-kappaB DNA binding activity, and that both IKKalpha and IKKbeta subunits are important kinases in the phosphorylation of the p65 subunit in the face of doxorubicin, the question remains whether the deletion of IKKalpha or IKKbeta would affect the overall survival of HT1080 cells treated with doxorubicin."

18644995

Doxorubicin affects CHUK

| 2

Doxorubicin inhibits CHUK. 2 / 2

| 2

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➶

reach

"Recently, it has also been shown that doxorubicin can initiate IkappaBalpha degradation and NF-kappaB activation independent of either IKKalpha or IKKbeta using the same in vitro models."

18644995

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➶

reach

"Having identified that IKKalpha has a dominant role in NF-kappaB DNA binding activity, and that both IKKalpha and IKKbeta subunits are important kinases in the phosphorylation of the p65 subunit in the face of doxorubicin, the question remains whether the deletion of IKKalpha or IKKbeta would affect the overall survival of HT1080 cells treated with doxorubicin."

18644995

Double-stranded RNA affects IFIH1

| 2

Double-stranded RNA inhibits IFIH1. 2 / 2

| 2

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➶

eidos

"A recent proposal is that MDA5 functions as a '' molecular ruler : '' whereas relatively short dsRNAs ( $ 100 nt ) can activate MDA5 when present in large quantites , longer dsRNAs ( 1-2 kb ) do so more efficiently as a result of the cooperative assembly of the helicase along dsRNA stems , the complex created by which forms filamentous oligomers that are important for signaling ( see below ) Feng et al ., 2012 ; Peisley et al ., 2012 ; Wu et al ., 2013a ) ."

23706667

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eidos

"A recent proposal is that MDA5 functions as a `` molecular ruler : '' whereas relatively short dsRNAs ( ~ 100 nt ) can activate MDA5 when present in large quantites , longer dsRNAs ( 1-2 kb ) do so more efficiently as a result of the cooperative assembly of the helicase along dsRNA stems , the complex created by which forms filamentous oligomers that are important for signaling ( see below ) ( Berke and Modis , 2012 ; Berke et al ., 2012 ; Feng et al ., 2012 ; Peisley et al ., 2012 ; 2011 ; Wu et al ., 2013a ) ."

23706667

Doramapimod affects MAP3K7

2 |

Doramapimod inhibits MAP3K7. 2 / 2

2 |

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➶

tas

No evidence text available

22014550

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➶

tas

No evidence text available

22037378

Dopamine affects IFNB1

| 2

Dopamine inhibits IFNB1. 2 / 2

| 2

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reach

"Immune subset studies indicated that DA suppressed secretion of IFN-beta, TNF-alpha, and IL-1beta by NK cells, as well as secretion of TNF-alpha by neutrophils and monocytes; however, DA upregulated IL-10 secretion by neutrophils, monocytes, B cells, Mphis, and DCs within the splenocyte population."

30165447

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➶

reach

"We show that both DA L and GDVII L disrupt IFN-beta gene transcription induction by IFN regulatory factor 3 (IRF-3) but do so at different points in the signaling pathway."

20610716

Disulfiram affects NLRP3

| 2

Disulfiram inhibits NLRP3. 2 / 2

| 2

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"In this study, we identified disulfiram (DSF), an old marketed drug as a treatment for alcoholism, could effectively inhibit NLRP3 inflammasome activation and suppress pyroptotic cell death."

32151746

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➶

reach

"Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation."

32151746

Disulfiram affects NFKB1

1 | 1

Disulfiram inhibits NFKB1. 2 / 2

1 | 1

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"In preclinical studies, disulfiram, when combined with copper ions, has been shown to act as a proteasome inhibitor, to induce oxidative stress, reduce NFkB activity, and enhance the sensitivity of cancer cells to chemotherapeutic drugs [XREF_BIBR]."

25593981

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➶

ctd

No evidence text available

10661865

Disodium selenite affects MAPK8

1 | 1

Disodium selenite inhibits MAPK8. 2 / 2

1 | 1

---

➶

ctd

No evidence text available

10644709

---

➶

reach

"Reduced JNK1 expression by small RNA interference abrogated sufficient activation of JNK1 by sodium selenite, leading to reduced inhibition of the beta-catenin signaling, resulting in reduced efficacy of inhibiting cell proliferation."

19904745

Disodium selenite affects JUN

2 |

Disodium selenite inhibits JUN. 2 / 2

2 |

---

➶

ctd

No evidence text available

10644709

---

➶

ctd

No evidence text available

17346688

Dioxygen affects NFKB1

| 2

Dioxygen inhibits NFKB1. 2 / 2

| 2

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reach

"Decreased p50 suggested the presence of a high oxygen affinity hemoglobin (Hb) variant."

32151172

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➶

reach

"Secondly, NF-KB activation can be inhibited by many antioxidants, metal chelators or oxygen scavengers (for a review, see [21])."

9037247

Dioxygen affects IKBKB

| 2

Dioxygen inhibits IKBKB. 2 / 2

| 2

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"Hypoxia stimulates NF-kappaB signaling in epithelial and macrophage cell lines by preventing the repression of IKKbeta by oxygen dependent prolyl hydroxylases."

27177159

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➶

reach

"Moreover, hypoxia induces activation of NF-kappaB in various tissues and cancers [45,56-61]; while the mechanism behind this effect is still somewhat obscure, it has recently been discovered that oxygen dependent prolyl hydroxylase activity drives the proteasomal degradation of IkappaB kinase-beta (IKKbeta), a key mediator of the canonical pathway of NF-kappaB activation; thus, increased expression of IKKbeta would be expected to up-regulate NF-kappaB activation in hypoxic cells [62,63]."

20089365

Diosmetin affects NLRP3

| 2

Diosmetin inhibits NLRP3. 2 / 2

| 2

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"Further supporting these results, in vitro experiments also showed that diosmetin activated Nrf2 and HO-1, as well as inhibited the NLRP3 inflammasome in both RAW264.7 and A549 cells."

28365974

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reach

"While further studies are required to acquire more insight into the mechanisms underlying how diosmetin leads to Nrf2 activation and NLRP3 inhibition, as well as the relationship between these two pathways."

28365974

Diosgenin affects RELA

| 2

Diosgenin inhibits RELA. 2 / 2

| 2

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reach

"Diosgenin down-regulates NF-kappaB p65 and p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice."

23246979

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➶

reach

"Besides, diosgenin could significantly suppress activation of NF-kappaB p65 and p50, p38 and expression of inducible nitric oxide synthase (iNOS) in LPS induced THP-1 cells."

23246979

Diosgenin affects NFKB1

| 2

Diosgenin inhibits NFKB1. 2 / 2

| 2

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reach

"Diosgenin down-regulates NF-kappaB p65 and p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice."

23246979

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➶

reach

"Besides, diosgenin could significantly suppress activation of NF-kappaB p65 and p50, p38 and expression of inducible nitric oxide synthase (iNOS) in LPS induced THP-1 cells."

23246979

Dioscin affects MYD88

| 2

Dioscin inhibits MYD88. 2 / 2

| 2

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reach

"In addition, dioscin also inhibited TLR4 and MyD88 pathway to decrease the levels of TRAF6 and the related proteins."

27155058

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➶

reach

"In addition, TLR4, myeloid differentiation primary response gene 88 (MyD88), p-IKKbeta, p-p65, and NF-kappaB p65 in nuclei levels were significantly reduced by dioscin."

32761488

Dihydrogenvanadate affects NFKBIA

| 2

Dihydrogenvanadate inhibits NFKBIA. 2 / 2

| 2

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"Indeed, JNK inhibition by a transient transfection of macrophages with a dominant negative SEK1, an upstream kinase of JNK, decreased vanadate induced IkappaBalpha degradation [21]."

11923072

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➶

reach

"Inactive IKKbeta was able to block vanadate induced degradation of IkappaBalpha, yet it was unable to influence the activation of JNK by vanadate."

10400652

Dihydroartemisinin affects FOS

| 2

Dihydroartemisinin inhibits FOS. 2 / 2

| 2

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"Accordingly, DHA attenuated the induction of c-Fos and nuclear factor of activated T cells c1 (NFATc1)."

27836739

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➶

reach

"In addition, DHA suppressed the transcription and protein expression of ERK1/2 downstream effectors c-Fos and c-Myc."

25778668

Dihydroartemisinin affects CASP1

| 2

Dihydroartemisinin inhibits CASP1. 2 / 2

| 2

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➶

reach

"DHA inhibits caspase-1 activity and IL-1beta maturation."

22515414

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➶

reach

"Here, we demonstrate that DHA inhibits 5-FU-induced IL-1beta secretion and caspase-1 activity in a MDSC cell line (MSC-2)."

31217433

Digoxin affects NLRP3

| 2

Digoxin inhibits NLRP3. 2 / 2

| 2

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reach

"C-AR and digoxin administration attenuated NLRP3 and cleaved caspase-1 expression, and then reduced IL-1beta production, which was indicative of the role in suppressing NLRP3 inflammasome activation."

28003810

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➶

reach

"Consistently, digoxin attenuated HIF-1a sustained NLRP3 inflammasome activation in macrophages."

31411894

Dieckol affects STAT1

| 2

Dieckol inhibits STAT1. 2 / 2

| 2

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reach

"Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-γ Stimulated HaCaT Human Keratinocytes.Chemokine is a group of factors to control the activity of white blood cells, and serves to control the infiltration of inflammatory cells (Yoshie et al., 2001), being closely related to various pathological processes, such as inflammation, allergy, and infectious diseases."

25995822

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➶

reach

"Dieckol also inhibited the activation of STAT1, a major transcription factor that activates the primary genes induced by IFN-γ."

25995822

Diclofenac affects NFKBIA

| 2

Diclofenac inhibits NFKBIA. 2 / 2

| 2

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"Diclofenac and the P. japonica extract, on the other hand, induced degradation of IkappaBalpha, which increased free NF-kappaB in cells."

21686046

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➶

reach

"Diclofenac induced the degradation of IkappaBalpha, which increased free nuclear factor kappaB (NF-kappaB) in cells."

16051228

Diazoxide affects NLRP3

| 2

Diazoxide inhibits NLRP3. 2 / 2

| 2

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reach

"Then we detected the activation of NLRP3 inflammsome pathway in rats during cerebral I/R injury, and found that the diazoxide could inhibit the activation of NLRP3 inflammasome, which indicated that mitochondrial dysfunction played a great role in activating NLRP3 inflammasome in cerebral I/R injury."

30153825

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➶

reach

"In addition, diazoxide could also suppress the upregulation of NLRP3, ASC, and cleaved caspase 1induced by OGD/R in primary microglia and BV2 cells (all p < 0.01)."

30153825

Dexmedetomidine affects RELA

| 2

Dexmedetomidine inhibits RELA. 2 / 2

| 2

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reach

"However, small dose of dexmedetomidine did not obviously inhibit the activation of NF-kappaB p65 induced by CLP operation."

23690665

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➶

reach

"Dexmedetomidine at the medium and large doses significantly attenuated activation of NF-kappaB p65 in septic rat lung."

23690665

Dexamethasone affects MAPK14

1 | 1

Dexamethasone inhibits MAPK14. 2 / 2

1 | 1

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➶

ctd

No evidence text available

14984747

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➶

medscan

"Our results show that Dexamethasone treatment inhibits cisplatin-induced cell apoptosis by up-regulation of cellular mitogen-activated protein kinase phosphatase-1 (MKP-1) and subsequent deactivation of p38 protein kinase."

21803700

Dexamethasone affects JUN

| 2

Dexamethasone inhibits JUN. 2 / 2

| 2

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➶

reach

"Dexamethasone, a synthetic glucocorticoid that inhibits activator protein-1 (AP-1), blocked palytoxin stimulated MMP-13 gene expression."

14575638

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➶

reach

"Dexamethasone suppressed the abundance of the c, Fos/c, and Jun complex in THP-1 cell nuclei, but there was no direct evidence for c-Fos and c-Jun transactivation through sites in the -172 to -52 bp region."

10748079

Dexamethasone affects IFNB1

| 2

Dexamethasone inhibits IFNB1. 2 / 2

| 2

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"It is of note that dexamethasone, representing the mainstay treatment of severe asthma, inhibited not only dsRNA induced BSMC generation of proinflammatory cytokines (TNF-alpha and CXCL8) but also IFN-beta and IFN-lambda 1 in this study."

23658644

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➶

reach

"IFN-beta production induced by TLR 4 agonists but not TLR 3 agonists was inhibited by dexamethasone."

21750146

Desmopressin affects RELA

| 2

Desmopressin inhibits RELA. 2 / 2

| 2

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reach

"DDAVP impaired the LPS induced activation of the phosphorylated NF-kappaB subunit p65 and RelA in cftr +/+ CCDs (XREF_FIG)."

17967904

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➶

reach

"DDAVP impaired the LPS induced activation of the phosphorylated NF-kappaB subunit p65 and RelA in cftr +/+ CCDs (XREF_FIG)."

17967904

Desferrioxamine B affects NFKBIA

| 2

Desferrioxamine B inhibits NFKBIA. 2 / 2

| 2

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"XREF_FIG, IL-1alpha treatment induced significant I-kappaBalpha degradation in 1 h whereas significant DFO induced I-kappaBalpha degradation was only seen after 16 h in IHOK and HN12 cells."

17850672

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➶

reach

"These findings indicate that DFO mediated I-kappaBalpha degradation and NF-kappaB binding induced the NF-kappaB-activating signal pathway to regulate the expression of the immunomodulatory target gene IL-8 in immortalized and malignant oral keratinocytes."

17850672

Daunorubicin(1+) affects RELA

| 2

Daunorubicin(1+) inhibits RELA. 2 / 2

| 2

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reach

"Similar to ARF, we found that UV-C, daunorubicin, and doxorubicin repressed the RelA transactivation domain when present as a Gal4 fusion protein."

15053878

---

➶

reach

"We also found that UV-C and daunorubicin repressed the TA2 subdomain (amino acids 428-521) of the RelA transactivation domain."

15053878

Cyclosporin A affects STAT1

| 2

Cyclosporin A inhibits STAT1. 2 / 2

| 2

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➶

reach

"CsA prevents the pulldown of IRF9, STAT1 and STAT2 by CypA (XREF_FIG)."

22902549

---

➶

reach

"Cyclosporine A was able to block the initial STAT1 activation, but STAT3 activation was only partially affected."

14687580

Cyclosporin A affects NFKB1

| 2

Cyclosporin A inhibits NFKB1. 2 / 2

| 2

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➶

reach

"Meyer et al. reported that CsA acts as a non competitive inhibitor of the chymotrypsin like activity of the proteasome, enabling it to block Lipopolysaccharide (LPS)-induced IkappaB degradation and p105 processing in vivo [XREF_BIBR]."

27043634

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➶

reach

"CsA neither inhibits the processing of the NF-kappa B1 precursor p105 to p50, nor does it " stabilize " the C-terminal portion of p105, I kappa B gamma, which is degraded during p105 processing to mature p50."

9247567

Cyclosporin A affects IRF9

| 2

Cyclosporin A inhibits IRF9. 2 / 2

| 2

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➶

reach

"CsA single agent also inhibited its target genes, IRF9 (interferon regulatory factor 9), ABCB1 and PPP3R2."

23757356

---

➶

reach

"CsA prevents the pulldown of IRF9, STAT1 and STAT2 by CypA (XREF_FIG)."

22902549

Cycloheximide affects STAT1

| 1 1

Cycloheximide inhibits STAT1. 2 / 2

| 1 1

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reach

"NF-kappa B activation was rapid and was not inhibited by a protein synthesis inhibitor cycloheximide, suggesting that these bacteria could directly activate NF-kappa B. STAT1, STAT3, and IFN regulatory factor-1 DNA binding was induced by both bacteria with delayed kinetics compared with NF-kappa B."

10725732

---

➶

medscan

"Cultured human microvascular endothelial cells exposed to lipopolysaccharides activated STAT1 in a delayed manner that was inhibited by cycloheximide treatment."

21346151

Cycloheximide affects NLRP3

| 2

Cycloheximide inhibits NLRP3. 2 / 2

| 2

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➶

reach

"To further elucidate whether oroxylin A could affect the inflammasome formation in the second step, cycloheximide was given before LPS to block NLRP3 protein synthesis."

28938606

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➶

reach

"As previously shown, NLRP3 inflammasome activation was critically dependent on the presence of LPS and abrogated by cycloheximide treatment (XREF_FIG, upper panel)."

21677136

Curcumin affects STAT1

| 2

Curcumin inhibits STAT1. 2 / 2

| 2

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➶

reach

"For example, curcumin suppressed STAT1 activation in murine dendritic cells and inhibited indoleamine 2,3-dioxygenase (IDO)-mediated suppression of T cell responses."

19723881

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➶

reach

"XREF_BIBR, XREF_BIBR, XREF_BIBR Curcumin has been shown to downregulate NAT activity and STAT1 activation (XREF_TABLE), thereby inhibiting cancer growth and inducing apoptosis in H1299 and A549 cells (XREF_FIG)."

28435333

Curcumin affects MAPK8

1 | 1

Curcumin inhibits MAPK8. 2 / 2

1 | 1

---

➶

ctd

No evidence text available

17372590

---

➶

reach

"However, as shown in Figure XREF_FIG, the treatment of curcumin remarkably inhibited the phorsphorylation of JNK3 rather than JNK1 and 2."

23210631

Cucurbitacin B affects RELA

| 2

Cucurbitacin B inhibits RELA. 2 / 2

| 2

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➶

reach

"Cucurbitacin B suppresses the transactivation activity of RelA and p65."

21344491

---

➶

reach

"Cucurbitacin B suppresses the transactivation activity of RelA and p65."

21344491

Crotamiton affects ITCH

| 2

Crotamiton inhibits ITCH. 2 / 2

| 2

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➶

reach

"In mice, crotamiton inhibited itch related behaviors induced by a TRPV4 selective agonist (GSK1016790A)."

29441811

---

➶

reach

"In mice, crotamiton inhibited itch related behaviors induced by a TRPV4 selective agonist (GSK1016790A)."

28612138

Crizotinib affects IKBKE

2 |

Crizotinib inhibits IKBKE. 2 / 2

2 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

Cortisol affects PYCARD

| 2

Cortisol inhibits PYCARD. 2 / 2

| 2

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➶

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"Interestingly, cortisol increment in carp after temperature related stress does not reduce antibody production or ASC in the animal."

26236311

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➶

reach

"In males ASC basal aromatase activity (20.5 +/-4.2 pmol/mg/h; n = 5) was inhibited by cortisol (10-7 M) alone (12.3 +/-1.8 pmol/mg/h) and in combination with insulin (6.6 +/-1.2 pmol/mg/h; men vs women, P < 0.005)."

10918534

Corticosterone affects FOS

| 1 1

Corticosterone inhibits FOS. 2 / 2

| 1 1

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➶

reach

"Corticosterone decreased maternal care, plasma oxytocin levels, milk consumption by the pups, the activation of oxytocinergic neurons in hypothalamic nuclei, and c-Fos immunoreactivity in MPOA neurons."

26297864

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➶

eidos

"In the PFC , in addition to FSS , corticosterone could raise c-fos expression , which was blocked by RU38486 ."

32574519

Copper(2+) affects JUN

| 1 1

Copper(2+) inhibits JUN. 2 / 2

| 1 1

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➶

reach

"CU was also shown to down-regulate AR and AR related cofactors (activator protein-1, NF k B) in LNCap and PC-3 CaP cell lines to reduce their proliferation ability [XREF_BIBR]."

19585538

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➶

sparser

"Gel-mobility shift analysis showed that oxLDL caused an increase in the DNA binding activity of activator protein-1 (AP-1) and nuclear factor kappaB (NF-kappaB), which was inhibited by Cu, Zn-SOD and/or catalase overexpression."

16600249

Concanamycin A affects TLR7

| 2

Concanamycin A inhibits TLR7. 2 / 2

| 2

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reach

"These data support the conclusion that concanamycin A treatment prevents the pDC IFNa response at the level of ligand recognition, implicating TLR7 or TLR9."

20532161

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➶

reach

"These data support the conclusion that concanamycin A treatment prevents the pDC IFNα response at the level of ligand recognition, implicating TLR7 or TLR9."

20532161

Colchicine affects NLRP3

| 2

Colchicine inhibits NLRP3. 2 / 2

| 2

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➶

reach

"More importantly, an alkaloid drug Colchicine which is known for its effects such as tubulin disruption, alteration of E-selectin distribution on endothelial surfaces, inducing loss of adhesion molecule L-selectins and preventing adhesion and recruitment of neutrophil, has also been shown to inhibit activation of the NLRP3 inflammasome."

32574259

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➶

reach

"Colchicine may inhibit activation of NLRP3 inflammasome and additionally may inhibit directly the synthesis of TNF-α and IL-6 [93]."

32299202

Colchicine affects CASP1

| 1 1

Colchicine inhibits CASP1. 2 / 2

| 1 1

---

➶

eidos

"Whether colchicine inhibits caspase-1 at physiologic concentrations , or whether colchicine accumulation in leukocytes is sufficient to block the inflammasome , remains to be determined ."

| PMC

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➶

reach

"Whether colchicine inhibits caspase-1 at physiologic concentrations, or whether colchicine accumulation in leukocytes is sufficient to block the inflammasome, remains to be determined.Another mechanism by which colchicine may suppress inflammation is by inhibition of superoxide production by neutrophils."

| PMC

Clozapine affects NFKB1

| 2

Clozapine inhibits NFKB1. 2 / 2

| 2

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reach

"N3 PUFAs (DHA 8.7 muM and EPA14.21 muM) or clozapine (3muM) significantly reduced poly I : C induced increase in iNOS, NFkB (p50 and p65), IL-6 and nitrite when compared to non treated cells."

30508574

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➶

reach

"N3 PUFAs (DHA 8.7 muM and EPA14.21 muM) or clozapine (3muM) significantly reduced poly I : C induced increase in iNOS, NFkB (p50 and p65), IL-6 and nitrite when compared to non treated cells."

30508574

Cisplatin affects MAPK8

| 1 1

Cisplatin inhibits MAPK8. 2 / 2

| 1 1

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reach

"A2780 cells were transiently transfected with pcDNA3 (FLAG)-JNK1-dn, which expresses a dominant negative allele of JNK1 with a FLAG tag, and then treated with 20 muM CDDP for 48 h. JNK activity was largely blocked due to expression of the dominant negative allele."

16105650

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➶

medscan

"Using primary mouse embryonic fibroblasts from MKP-1 knockout mice, we show that induction of MKP-1 by cisplatin correlates with inactivation of c-Jun NH(2)-terminal kinase (JNK) but not ERK and p38."

16951204

Cisplatin affects JUN

| 2

Cisplatin inhibits JUN. 2 / 2

| 2

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➶

reach

"Cisplatin treatment decreased ERK-, JNK- and c-Jun activity in alpha-catulin knockdown melanoma cells, which was accompanied by reduced cell proliferation and enhanced apoptosis compared to control cells."

25793618

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➶

reach

"In the resected tumor tissues, the miR-216b-overexpressed tumors expressed obviously lower level of c-Jun and Bcl-xl compared to the control tumors after they were treated with equal dose of cisplatin."

29262633

Cisplatin affects IFIH1

| 2

Cisplatin inhibits IFIH1. 2 / 2

| 2

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sparser

"This is the first report demonstrating the inhibition of helicase and ATPase activities of a helicase (PDH45) by cisplatin."

12051716

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➶

sparser

"This is the first study to show the effect of various DNA-binding agents on the plant nuclear helicase and also first to demonstrate inhibition of any helicase by cisplatin."

12051716

Cimetidine affects FOS

| 2

Cimetidine inhibits FOS. 2 / 2

| 2

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"The H1 histamine antagonist diphenhydramine, but not the H2 histamine antagonist cimetidine, reduced the amount of c-fos labeling."

8193936

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➶

reach

"The c-Fos response to HCl was diminished by cimetidine and omeprazole, enhanced by pentagastrin, and left unchanged by dexloxiglumide and itriglumide."

14592947

Cilostazol affects RELA

| 2

Cilostazol inhibits RELA. 2 / 2

| 2

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reach

"Inhibition of NF-kappaB p65 activation by cilostazol."

25126750

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➶

reach

"RLP significantly degraded inhibitory kappaBalpha in the cytoplasm and activated nuclear factor-kappaB (NF-kappaB) p65 in the nucleus of HUVECs with increased luciferase activity of NF-kappaB, all of which were reversed by cilostazol (10 microM), BAY 11-7085, and polyinosinic acid."

15525793

Cidofovir anhydrous affects STAT2

| 1 1

Cidofovir anhydrous inhibits STAT2. 2 / 2

| 1 1

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reach

"Svitek et al. (2014) demonstrated that CDV has to block STAT2 signaling for immune evasion in ferrets, whereas inhibition of STAT1 does not contribute to CDV virulence [XREF_BIBR]."

30939763

---

➶

eidos

"Svitek et al. ( 2014 ) demonstrated that CDV has to block STAT2 signaling for immune evasion in ferrets , whereas inhibition of STAT1 does not contribute to CDV virulence [ 45 ] ."

30939763

Chondroitin affects NFKB1

| 2

Chondroitin inhibits NFKB1. 2 / 2

| 2

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"XREF_BIBR, XREF_BIBR Corroborating evidence has shown that glucosamine and chondroitin reduce factors downstream of NFkB, including : tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), cyclooxygenase-2 (COX-2), and prostaglandin E 2 (PGE 2)."

27357024

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➶

reach

"It has been suggested that chondroitin may act to block NFkB activation via the inhibition of reactive oxygen species."

23917455

Cholesterol affects TBK1

| 2

Cholesterol inhibits TBK1. 2 / 2

| 2

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"Addition of free cholesterol to SREBP2-knockout cells significantly decreased pTBK1, while blocking IFNAR had no effect on pTBK1 levels, reinforcing the idea that cholesterol directly influences STING mediated activation of TBK1."

29915602

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➶

reach

"Addition of free cholesterol to SREBP2-knockout cells significantly decreased pTBK1, while blocking IFNAR had no effect on pTBK1 levels, reinforcing the idea that cholesterol directly influences STING-mediated activation of TBK1."

29915602

Cholesterol affects STING1

| 2

Cholesterol inhibits STING1. 2 / 2

| 2

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"XREF_BIBR The authors reported that a reduced cholesterol pool size resulting from limited flux through the mevalonate pathway could spontaneously induce a type I IFN response in a stimulator of interferon genes (STING, TMEM173)-dependent fashion."

29123952

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➶

reach

"However recent work suggests that reduction of cholesterol biosynthesis directly drives the anti-viral response via the ER bound signalling protein STING rather than decreasing nutrient availability to the virus."

28683280

Chloroquine affects NFKBIA

| 1 1

Chloroquine inhibits NFKBIA. 2 / 2

| 1 1

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➶

medscan

"Therefore, blocking autophagy with chloroquine prevented bortezomib-induced nuclear factor-κB activation by reducing IκBα degradation and enhanced bortezomib-induced killing of lymphoma cells ( )."

23546223

---

➶

reach

"A caveat is that the lysosome inhibitor chloroquine actually enhances NF-kappaB activity by inhibiting resynthesis of IkappaB-alpha [72]."

9920280

Chloroquine affects MYD88

| 2

Chloroquine inhibits MYD88. 2 / 2

| 2

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"Chloroquine (CQ) has been shown to affect LPS-TLR4 colocalization and inhibit both MyD88 dependent and TRAM and TRIF dependent pathways, though the mechanism involved is still poorly understood."

28134560

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➶

reach

"Chloroquine, an inhibitor of CpG triggered cytokine secretion, blocked TLR9 and MyD88 dependent cytokine secretion as expected but failed to inhibit CpG induced Src family kinase activation and its dependent cellular responses."

16567503

Ceruletide affects NFKBIA

| 2

Ceruletide inhibits NFKBIA. 2 / 2

| 2

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"In this study, cerulein increased the levels of phosphorylated IkappaBalpha, but decreased those of total IkappaBalpha; this effect, in the rat pancreas, was inhibited by treatment with DHA."

28704954

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➶

reach

"As shown in Fig. 2 B, cerulein caused a rapid degradation of IkappaBalpha, pioglitazone at 40 muM completely blocked the degradation of IkappaBalpha and the inhibitory effects were reversed by GW9662."

18490130

Ceruletide affects IFNAR1

| 2

Ceruletide inhibits IFNAR1. 2 / 2

| 2

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"Serum levels of IFN-beta and IP-10, whose production requires activation of type I IFN signaling, were markedly reduced in Ifnar1 -/- mice treated with FK156 and low-dose cerulein as compared with those in Ifnar1 +/+ mice."

22902233

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➶

reach

"Caerulein induced pancreatitis is focally restricted in Ifnar del mice."

26618925

Ceramide affects CASP1

| 2

Ceramide inhibits CASP1. 2 / 2

| 2

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"The LPS priming and ceramide induced caspase-1 activation was reduced in adipose tissue explants of Nlrp3 deficient mice (XREF_FIG)."

21217695

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➶

reach

"Notably, ceramide induced caspase-1 activation is blocked in the absence of Nlrp3 (XREF_FIG)."

21217695

Celecoxib affects RELA

| 2

Celecoxib inhibits RELA. 2 / 2

| 2

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reach

"Celecoxib just slightly reduced NF-kappaB p65 mRNA in the T2DM-NASH-Cele group (XREF_FIG)."

24404139

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➶

reach

"The results from the NF-kappaB activity assay suggested that SIRT1 activation led to decreased nuclear translocation of NF-kappaB (p65) in the liver and spleen tissues of mice treated with imipenem or celecoxib alone and in combination."

28533769

Carbon monoxide affects EIF2AK1

| 2

Carbon monoxide inhibits EIF2AK1. 2 / 2

| 2

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"HRI is activated by NO binding to the heme, which displaces both endogenous ligands, but HRI is inhibited by formation of the 6-coordinate CO adduct."

19405475

---

➶

reach

"Other investigators reported that CO directly inhibited the kinase activity of HRI in vitro [51,52]."

28347842

Carbon monoxide affects CASP1

| 2

Carbon monoxide inhibits CASP1. 2 / 2

| 2

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"Inhalation of CO significantly reduced mtDNA and IL-1beta secretion, and also decreased caspase-1 activation in response to mitochondrial damage."

30333475

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➶

reach

"Here, we demonstrated that CO inhibited caspase-1 activation and the secretion of IL-1beta and IL-18 in response to lipopolysaccharide (LPS) and ATP treatment in bone marrow derived macrophages."

25770182

Capsaicin affects NFKBIA

| 2

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| 2

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"Capsaicin or capsazepine completely blocked LPS induced disappearance of IkB-a, indicating that the subsequent NF-kB inactivation was induced by both compounds.Since capsazepine could not abolish the inhibitory action of capsaicin on PGE2 release, we investigated whether VR-1 mRNA is expressed in peritoneal macrophages by RT-PCR analysis."

12531428

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➶

reach

"Capsaicin completely blocked LPS induced disappearance of IkB-a and therefore inactivated NF-kB."

12531428

Capsaicin affects JAK1

1 | 1

Capsaicin inhibits JAK1. 2 / 2

1 | 1

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➶

ctd

No evidence text available

17505005

---

➶

reach

"Capsaicin also inhibited IL-6-induced STAT3 activation as well as the activation of JAK1 and c-Src."

24388873

Calycosin affects RELA

| 2

Calycosin inhibits RELA. 2 / 2

| 2

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"The calycosin (50 mg/kg) and 5-ASA inhibited the phosphorylation of IKKα/β, IκBα and p65 to attenuate the inflammation, which was consistent with the suppression of mRNA expressions ( xref )."

29085602

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sparser

"The calycosin (50 mg/kg) and 5-ASA inhibited the phosphorylation of IKKα/β, IκBα and p65 to attenuate the inflammation, which was consistent with the suppression of mRNA expressions ( xref )."

29085602

Calcium(2+) affects NFKB1

| 2

Calcium(2+) inhibits NFKB1. 2 / 2

| 2

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"In this study, we demonstrate that mangiferin interferes with inflammation, lipid and calcium signaling which selectively inhibits multiple NFkB target genes including interleukin-6, tumor necrosis factor, interferon gamma, vascular endothelial growth factor receptor 2, plasminogen activator urokinase, matrix metalloprotease 19, C-C Motif Chemokine Ligand 2 and placental growth factor."

31651714

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➶

reach

"In presence of spermineNONOate there is an increase of erythrocyte deformability, plasma pH, decrease of Na (+) and Ca (2+) concentration, increase of metHb concentration and decrease of p50."

11847418

Calcitriol affects STAT1

| 2

Calcitriol inhibits STAT1. 2 / 2

| 2

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reach

"We previously demonstrated the ability of calcitriol to decrease STAT1 tyrosine 701 (p-STAT1) and STAT3 tyrosine 705 (p-STAT3) phosphorylation as well as inflammatory cytokine output of T cell large granular lymphocyte leukemia cells, but did not determine the effects of calcitriol on NK-LGLL."

30455079

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➶

reach

"Thus, strategies that ameliorate HGPS cellular phenotypes mimic the effect of calcitriol, reducing RS and repressing the STAT1 pathway, though calcitriol 's effect is the most robust."

29466729

Caffeine affects STAT1

| 2

Caffeine inhibits STAT1. 2 / 2

| 2

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"Caffeine inhibits STAT1 signaling and downregulates inflammatory pathways involved in autoimmunity."

29678503

---

➶

reach

"Upstream regulator analysis suggests that caffeine inhibits STAT1 signaling, which was confirmed by showing reduced phosphorylated STAT1 after caffeine treatment."

29678503

Caffeine affects NLRP3

| 2

Caffeine inhibits NLRP3. 2 / 2

| 2

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"Given these findings, we conclude that caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK and NF-kappaB signaling and A2aR associated ROS production in LPS induced THP-1 macrophages."

31360100

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➶

reach

"Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK and NF-kappaB and A2aR Signaling in LPS Induced THP-1 Macrophages."

31360100

Caffeine affects CASP1

| 2

Caffeine inhibits CASP1. 2 / 2

| 2

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"Unexpectedly, caffeine (XREF_FIG) and more importantly antagonism of the A1+ A2A ARs (XREF_FIG) prevented reoxygenation dependent activation of caspase 1 while NAC did not (XREF_FIG)."

23035103

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➶

reach

"XREF_FIG demonstrate that caffeine but not NAC inhibits adenosine dependent activation of caspase 1 when adenosine is perfused into mice (XREF_FIG, main effect of treatment (P < 0.001)."

23035103

Cadmium(2+) affects JUN

| 2

Cadmium(2+) inhibits JUN. 2 / 2

| 2

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"When cells were treated with ASO c-Jun, the total amounts of c-Jun and also cadmium induced c-Jun activation were diminished."

26408417

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➶

reach

"Enhanced expression of p53 and apoptosis in ventral prostate (not the case in testes) may be a tissue reaction working to diminish the activation of c-jun by cadmium."

10647914

Cadmium dichloride affects RELA

1 | 1

Cadmium dichloride inhibits RELA. 2 / 2

1 | 1

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"On the other hand, cadmium chloride strongly reduced DNA binding activity of all forms in both resting and antigen stimulated lymphocytes.Exposure to 10 muM of orthovanadate increased the inducible p50 and p65 form of NF-kappaB in resting, but not in antigen stimulated splenocytes."

11696409

---

➶

ctd

No evidence text available

16478757

Cadmium atom affects PYCARD

| 2

Cadmium atom inhibits PYCARD. 2 / 2

| 2

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"Cd stress significantly decreased TA and ASC and DHA in both sexes when compared with the controls."

21778178

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➶

reach

"Cadmium (Cd) stress significantly decreased membrane integrity and impaired the ascorbate (ASC)-glutathione (GSH) cycle in tobacco Bright Yellow-2 cells."

19809168

Cadmium atom affects JUN

| 2

Cadmium atom inhibits JUN. 2 / 2

| 2

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reach

"Moreover, addition of celastrol exhibited more inhibitory effect on Cd activated c-Jun and cell death (XREF_FIG)."

24111524

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➶

reach

"Of importance, addition of rapamycin showed more inhibitory effect on Cd induced activation of c-Jun and Erk1/2, as well as apoptosis in Ad-dn-c-Jun group or Ad-MKK1-K97M group than in Ad-GFP group."

26805420

Butyric acid affects RELA

| 2

Butyric acid inhibits RELA. 2 / 2

| 2

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"Butyrate also reduced the residual p65 localisation observed in CrD biopsies cultured in the absence of any EC- LPS stimulation (XREF_SUPPLEMENTARY)."

22412931

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➶

reach

"Compared to the model group, sodium butyrate treatment significantly improved the histopathological changes in the liver and intestine, reduced serum endotoxin and inflammatory cytokines, suppressed HMGB1 and NF-kappaB p65 proteins in liver tissue, and prolonged the survival duration regardless of treatment at 12 hours or 24 hours after induction of ALF (P < 0.05)."

24919615

Butyric acid affects NFKBIA

| 2

Butyric acid inhibits NFKBIA. 2 / 2

| 2

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"Co-incubation of butyrate and TNFalpha enhanced the decrease of IkappaBalpha (-83%, p < 0.001; Fig. 3)."

17521736

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➶

reach

"Furthermore, butyrate prevented the activation of nuclear factor (NF)-kappaB through the stabilization of IkappaB-alpha and IkappaB-beta."

11052179

Butyric acid affects CASP1

| 2

Butyric acid inhibits CASP1. 2 / 2

| 2

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"However, propionate had no effects on 7-Ket-stimulated increase in caspase-1 levels, while butyrate even reduced this 7-Ket-stimulated activation of caspase-1 (XREF_FIG A and B)."

29475132

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➶

reach

"However, butyrate blocked endothelial caspase-1 activation in PLCA."

29475132

Bumetanide affects TRAF6

| 2

Bumetanide inhibits TRAF6. 2 / 2

| 2

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"TRAF6, which is upstream of p38 MAPK and NF-kappaB, was attenuated by bumetanide after IR and HR."

30271405

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➶

reach

"Epithelial TRAF6 is attenuated by bumetanide in IR-ALI."

30271405

Bufexamac affects IFNB1

| 2

Bufexamac inhibits IFNB1. 2 / 2

| 2

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"While both Bufexamac and TSA treatment blocked IFN-beta promoter induction by SenV in a dose dependent manner, treatment of cells with VPA did not decrease IFN-beta promoter induction as compared to nontreated cells (XREF_FIG A)."

27372014

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➶

reach

"TSA also blocked IFN-beta promoter induction by the constitutively active N-RIG construct but importantly, Bufexamac treatment did not block IFN-beta promoter induction by N-RIG."

27372014

Brazilin affects NFKB1

| 2

Brazilin inhibits NFKB1. 2 / 2

| 2

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➶

reach

"Brazilin suppressed the IL1beta mediated upregulation of OA markers and the induction of NFKB1 and p50 in chondrocytes."

29704279

---

➶

reach

"Brazilin suppressed the IL1beta mediated upregulation of OA markers and the induction of NFKB1 and p50 in chondrocytes."

29704279

Bosutinib affects TBK1

2 |

Bosutinib inhibits TBK1. 2 / 2

2 |

---

➶

tas

No evidence text available

19039322

---

➶

tas

No evidence text available

22037378

Biphenyl affects NLRP3

| 2

Biphenyl inhibits NLRP3. 2 / 2

| 2

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"Novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy."

31768838

---

➶

reach

"Correction to : novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy."

31970602

Biochanin A affects RELA

| 2

Biochanin A inhibits RELA. 2 / 2

| 2

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"In this study, we showed that biochanin A inhibited IkappaB-alpha degradation and then attenuated the activation of NF-kappaB p65."

25398247

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➶

reach

"As expected, biochanin A inhibited IL-1beta-stimulated activation of NF-kappaB p65 and suppressed the IL-1beta-induced degradation of IkappaB-alpha, as shown in Figures XREF_FIG and XREF_FIG."

25398247

Biochanin A affects NLRP3

| 2

Biochanin A inhibits NLRP3. 2 / 2

| 2

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"In conclusion, biochanin A protected against LPS and GalN induced liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation."

27344638

---

➶

reach

"Biochanin A protected against LPS and GalN induced liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation."

27344638

Bilirubin IXalpha affects EIF2AK1

| 1 1

Bilirubin IXalpha inhibits EIF2AK1. 2 / 2

| 1 1

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➶

sparser

"Finally, we found that HRI is inhibited by bilirubin at physiological/pathological levels (IC(50) = 20 microM)."

16893190

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➶

reach

"Finally, we found that HRI is inhibited by bilirubin at physiological and pathological levels (IC (50) = 20 microM)."

16893190

Betulinic acid affects CHUK

| 2

Betulinic acid inhibits CHUK. 2 / 2

| 2

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"It was also observed that betulinic acid inhibited the activation of IKKa and NF-kB induced by various NF-kB activators (Takada and Aggarwal, 2003) ."

32300254

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➶

reach

"It was also observed that betulinic acid inhibited the activation of IKKalpha and NF-kappaB induced by various NF-kappaB activators."

32300254

Betamethasone affects ITCH

| 2

Betamethasone inhibits ITCH. 2 / 2

| 2

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➶

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"Betamethasone scalp lotion and coal tar shampoo relieved the scalp itch from the ingrown hairs, while hair dyeing helped to make the white hairs less visible and improve her compliance to advice against pulling her hair."

22223968

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➶

reach

"Betamethasone valerate 0.1%-impregnated occlusive tape significantly decreased itch compared with an antipruritic moisturizing cream containing feverfew, a traditional medicinal herb."

30881076

Beta-aminoarteether maleate affects STAT1

| 2

Beta-aminoarteether maleate inhibits STAT1. 2 / 2

| 2

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➶

reach

"Further investigations revealed that SM934 treatment significantly suppressed the excessive activation of STAT1, STAT3, and STAT5 in lupus."

25960615

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➶

reach

"Ex vivo, SM934 treatment elevated the percentage of Treg cells, inhibited the development of Th1 and Th17 cells, and impeded the comprehensive activation of STAT-1, STAT-3, and STAT-5 proteins in splenocytes."

21484768

Beta-D-glucose affects CASP1

| 2

Beta-D-glucose inhibits CASP1. 2 / 2

| 2

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➶

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"Remarkably, curdlan triggered caspase-1 processing was also impaired in CR3 deficient cells, suggesting that CR3 is important for inflammasome mediated caspase-1 activation in response to beta-glucans."

25063877

---

➶

reach

"Curdlan induced caspase-1 processing was also markedly reduced in Clec7a -/- BMDC, indicating that dectin-1 signaling is important for beta-glucan induced caspase-1 activation (XREF_FIG)."

25063877

Baicalin affects RELA

| 2

Baicalin inhibits RELA. 2 / 2

| 2

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➶

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"In RAW264.7 cells with CD14 knockdown, baicalin pretreatment did not prevent inflammatory responses and activation of MyD88 and NF-kappaB p65 pathway induced by high concentrations (1000mug/mL) of LPS."

32457419

---

➶

reach

"Interestingly, we observed very low expression level of RelA in TAMs, and baicalin treatment could suppress RelA even in the presence of soluble TNF-alpha, a RelA activating cytokine (XREF_FIG)."

26492375

Baicalin affects PYCARD

| 2

Baicalin inhibits PYCARD. 2 / 2

| 2

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➶

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"On the contrary, baicalin treatment could either inhibit the formation of ASC specks in immunofluorescence or decrease the NLRP3, ASC, pro-caspase-1 in a dose dependent manner."

29163427

---

➶

reach

"As shown in Figure XREF_FIG, Mtb induced the accumulation of ASC protein which represented the activation of NLRP3 inflammasome, and baicalin treatment decreased the ASC specks."

29163427

Baicalin affects CASP1

| 2

Baicalin inhibits CASP1. 2 / 2

| 2

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"In line with the results derived from ATP stimulation, baicalin also markedly reduced caspase-1 activation and mature IL-1beta secretion in a dose dependent manner upon nigericin stimulation, indicating the suppression of NLRP3 activation."

29163487

---

➶

reach

"On the contrary, baicalin treatment could either inhibit the formation of ASC specks in immunofluorescence or decrease the NLRP3, ASC, pro-caspase-1 in a dose dependent manner."

29163427

Baicalein affects NLRP3

| 2

Baicalein inhibits NLRP3. 2 / 2

| 2

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➶

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"Baicalein also inhibited NLRP3 and caspase-1 activation and suppressed gasdermin D (GSDMD)-dependent pyroptosis."

32761175

---

➶

reach

"Baicalein reduced the activation of the NLRP3 inflammasome."

29180692

Baicalein affects MYD88

| 2

Baicalein inhibits MYD88. 2 / 2

| 2

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➶

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"In this study, we showed that baicalein significantly inhibited the up-regulation of TLR4 and MyD88 in TNBS induced colitis mice and in LPS induced macrophages."

29180692

---

➶

reach

"Baicalein decreased the activation of TLR4 and MyD88 signaling molecules."

29180692

Bafilomycin A1 affects NLRP3

| 2

Bafilomycin A1 inhibits NLRP3. 2 / 2

| 2

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➶

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"Previously, we demonstrated that blockade of the intracellular clearance systems in human retinal pigment epithelial (RPE) cells by MG-132 and bafilomycin A1 (BafA) induces NLRP3 inflammasome signaling."

30138927

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➶

reach

"Whether Bafilomycin A1 inhibition of NLRP3 inflammasome activity with silica exposure is due to direct inhibition of LMP, or inhibition of the activation of cathepsin B, is not known."

28126413

Bafilomycin A1 affects NFKBIA

| 2

Bafilomycin A1 inhibits NFKBIA. 2 / 2

| 2

---

➶

medscan

"Interestingly, inhibition of lysosomal activity by Bafilomycin A1 inhibits ST80/Bortezomib-stimulated IκBα degradation, nuclear factor-kappa B activation and BAG3 upregulation, indicating that IκBα is degraded via the lysosome in the presence of Bortezomib."

25766331

---

➶

medscan

"This conclusion is based on our data showing that impairment of lysosomal acidification by the V-ATPase inhibitor Bafilomycin A1 prevents ST80/Bortezomib-stimulated IκBα degradation, nuclear factor-kappa B activation and BAG3 upregulation."

25766331

Azelastine affects ITCH

| 2

Azelastine inhibits ITCH. 2 / 2

| 2

---

➶

reach

"Inhibitory effects of azelastine on substance P induced itch associated response in mice."

11858803

---

➶

reach

"We examined whether azelastine would inhibit itch associated responses of mice to mosquito allergy."

12686751

Auranofin affects IRF3

| 2

Auranofin inhibits IRF3. 2 / 2

| 2

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➶

reach

"IRF3 activation induced by MyD88 independent signaling components, TRIF and TBK1, was also downregulated by auranofin."

17034761

---

➶

reach

"Auranofin inhibited nuclear factor-kappaB and interferon (IFN) regulatory factor 3 (IRF3) activation induced by polyinosinic-polycytidylic acid (poly [I : C])."

20607500

Atorvastatin affects MYD88

| 2

Atorvastatin inhibits MYD88. 2 / 2

| 2

---

➶

reach

"Atorvastatin decreased the neural injury and the elevation of TLR4, MyD88, TRIF, pro inflammatory cytokines and oxidative stress caused by CIH."

26200444

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➶

reach

"In conclusion, Pre-CIH atorvastatin administration may attenuate TLR-4 and MYD88 mediated inflammatory processes and oxidative stress in the injured rat myocardium, and this may be one mechanism by which atorvastatin ameliorated myocardial injury following CIH."

24582748

Arsenite(3-) affects JUN

| 2

Arsenite(3-) inhibits JUN. 2 / 2

| 2

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➶

reach

"Perhaps the arsenite induced activation of c-jun blocks the p21 induction in that system as well.Low levels of arsenite (0.5-10 muM) cause an increase in ubiquitinated proteins [292]."

14643412

---

➶

reach

"As c-Jun is activated through double phosphorylation by the JNK pathway, when JNK inhibitor (SP600125) was used to block the activation of JNK, the arsenite induced activations of c-Jun and miR-21 were decreased."

23469214

Arachidonic acid affects CASP1

| 1 1

Arachidonic acid inhibits CASP1. 2 / 2

| 1 1

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➶

sparser

"AA pretreatment reversed caspase-1 protein and mRNA levels that increased by ethanol challenge (Figures xref ), which also demonstrated that AA inhibited caspase-1 to block the processing and release of pro-inflammation cytokines."

28360860

---

➶

reach

"AA pretreatment reversed caspase-1 protein and mRNA levels that increased by ethanol challenge, which also demonstrated that AA inhibited caspase-1 to block the processing and release of pro inflammation cytokines."

28360860

Apocynin affects NLRP3

| 2

Apocynin inhibits NLRP3. 2 / 2

| 2

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➶

reach

"Intriguingly, delayed administration of apocynin at 24 h post-injury also attenuated oxidative damage, reduced NLRP3 inflammasome activation, and promoted microglial polarization towards the M2 like phenotype following TBI in the mouse [79,82]."

29571125

---

➶

reach

"Intriguingly, delayed administration of apocynin at 24h post-injury also attenuated oxidative damage, reduced NLRP3 inflammasome activation, and promoted microglial polarization towards the M2 like phenotype following TBI in the mouse XREF_BIBR, XREF_BIBR."

29571125

Apocynin affects NFKB1

| 2

Apocynin inhibits NFKB1. 2 / 2

| 2

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➶

reach

"Apocynin dose- dependently inhibits the NF-KB- dependent release of tumor necrosis factor (TNF) from human adherent mononuclear cells induced by pepti- doglycan from Gram positive bac- teria."

7888061

---

➶

reach

"Apocynin dose- dependently inhibits the NF-KB- dependent release of tumor necrosis factor (TNF) from human adherent mononuclear cells induced by pepti- doglycan from Gram positive bac- teria."

7888060

Apocynin affects IFNB1

| 1 1

Apocynin inhibits IFNB1. 2 / 2

| 1 1

---

➶

eidos

"IL6 ( Fig. 2A ) , IFNB1 ( Fig. 2B ) , CXCL10 ( Fig. 2C ) , and CCL5 ( Fig. 2D ) gene expression was significantly elevated in ATII cells following infection and was reduced by the addition of apocynin ( except for IFNB1 ) ."

30341336

---

➶

reach

"IL-6 (Fig. 2A), IFN-β(Fig. 2B), CXCL10(Fig. 1682C), and CCL5(Fig. 2D)gene expression was significantly elevated in ATII cells following infection 169and was reduced by the addition of apocynin (except for IFN-β) (Fig. 2A-D)."

| DOI

Apigenin affects MAPK14

| 2

Apigenin inhibits MAPK14. 2 / 2

| 2

---

➶

medscan

"Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by apigenin via the inhibition of p38 mitogen-activated protein kinase-dependent matrix metalloproteinase-9 expression."

20514473

---

➶

medscan

"However, higher doses (>10 mumol/L) of apigenin inhibited ERalpha mobility (as determined by fluorescence recovery after photobleaching assays), down-regulated ERalpha and amplified in breast cancer-1 expression levels, and inhibited multiple protein kinases, including p38, protein kinase A, mitogen-activated protein kinase, and AKT."

18645020

Antimony(3+) affects MAPK14

| 2

Antimony(3+) inhibits MAPK14. 2 / 2

| 2

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➶

sparser

"However, our previous results showed that SB, which inhibits both p38α and p38β, did not affect ESC differentiation to SMCs, ECs and neurons, which argues against a role of p38β for ESC differentiation to these cells ( xref )."

19539422

---

➶

sparser

"To test whether p38β plays a role in mediating the effect of TNF-α, we treated the cells with 1μM SB, which inhibits both p38α and p38β."

18613029

Anthra[1,9-cd]pyrazol-6(2H)-one affects NFKBIA

| 2

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits NFKBIA. 2 / 2

| 2

---

➶

reach

"As it was expected, Bay and SP inhibited the activation of IkappaBalpha and JNK, respectively."

29957360

---

➶

reach

"However, salusin-beta treatment resulted in the obvious up-regulation of NF-kappaBp65 and down-regulation of I-kappaBalpha (P < 0.05, P < 0.01, XREF_FIG), which was antagonized by SB203580 and SP600125 (P < 0.05, P < 0.01)."

25210730

Anthra[1,9-cd]pyrazol-6(2H)-one affects MAP3K7

| 2

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits MAP3K7. 2 / 2

| 2

---

➶

reach

"The MAPK-JNK pathway inhibitor SP600125 clearly blocked the antiviral effect of TAK1 (XREF_FIG, lane 10), indicating the essential role of this pathway in controlling of HBV replication."

28045080

---

➶

reach

"Furthermore, the JNK pathway was apparently responsible for the suppression of HBV replication, as the JNK inhibitor, SP600125, and JNK3 siRNA attenuated the antiviral effects of TAK1."

28045080

Anthra[1,9-cd]pyrazol-6(2H)-one affects IKBKB

| 1 1

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits IKBKB. 2 / 2

| 1 1

---

➶

sparser

"Salicylic acid and SP600125 partially inhibited IKKbeta and JNK, respectively, which indicated distinct roles for these two kinases in the phosphorylation of IRS1 at the two serine sites."

16896943

---

➶

reach

"Salicylic acid and SP600125 partially inhibited IKKbeta and JNK, respectively, which indicated distinct roles for these two kinases in the phosphorylation of IRS1 at the two serine sites."

16896943

Anthra[1,9-cd]pyrazol-6(2H)-one affects IFNB1

| 2

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits IFNB1. 2 / 2

| 2

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➶

reach

"Furthermore, SP600125 also significantly inhibited secretion of IFN-beta (XREF_FIG) suggesting that Poly I : C induced IL-1beta, TNFalpha, IL-12p70 and IFN-beta production in keratinocytes is mediated by JNK signaling pathway."

20728939

---

➶

reach

"In this study, JNK inhibitor SP600125 prevented the upregulation of IL-1beta, TNFalpha, IL12p70 and IFN-beta upon stimulation with Poly I : C, suggesting that intracellular signaling by the JNK pathway contributes to regulation of proinflammatory cytokines and type I IFN."

20728939

Anthra[1,9-cd]pyrazol-6(2H)-one affects FOS

| 1 1

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits FOS. 2 / 2

| 1 1

---

➶

sparser

"TGFβ also induced phosphorylation of (S351) NR4A1, JNK1, c-jun and c-fos which was also inhibited by SP600125, demonstrating that TGFβ induces JNK and genes downstream from JNK."

30072581

---

➶

reach

"Moreover, the present study showed that IL-17A induced the nuclear translocation of c-Jun and c-Fos, which could be effectively inhibited by the JNK inhibitor SP600125 or the p38 inhibitor SB203580."

26988982

Antagonist affects IRF3

| 2

Antagonist inhibits IRF3. 2 / 2

| 2

---

➶

reach

"Lui et al. reported that the MERS-CoV M glycoprotein is an IFN antagonist because it specifically inhibited IRF3 activation but not NF-κB signaling (41)."

28848548

---

➶

reach

"Here we identify TRIM56 as a cellular protein associated with the N-terminal protease (N(pro)) of bovine viral diarrhea virus (BVDV), a pestiviral interferon antagonist which degrades interferon regulatory factor 3 (IRF3) through the proteasome."

21289118

Anandamide affects NLRP3

| 2

Anandamide inhibits NLRP3. 2 / 2

| 2

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➶

reach

"Given the demonstrated anti-inflammatory effects of endocannabinoids, the present study was designed to test whether anandamide (AEA) or its metabolites diminish NLRP3 inflammasome activation and prevent podocyte injury and associated glomerular damage during hyperhomocysteinemia (hHcys)."

27189966

---

➶

reach

"Given the demonstrated anti-inflammatory effects of endocannabinoids, the present study was designed to test whether anandamide (AEA) or its metabolites diminish NLRP3 inflammasome activation and prevent podocyte injury and associated glomerular damage during hyperhomocysteinemia (hHcys)."

27189966

Alvocidib affects FOS

| 2

Alvocidib inhibits FOS. 2 / 2

| 2

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➶

reach

"Flavopiridol also inhibited the TNF induced induction of intercellular adhesion molecule-1, c-Myc, and c-Fos, all known to mediate tumorigenesis [XREF_BIBR]."

21561421

---

➶

reach

"Flavopiridol also inhibited the TNF induced induction of intercellular adhesion molecule-1, c-Myc, and c-Fos, all known to mediate tumorigenesis."

18287248

Alvespimycin affects RELA

| 2

Alvespimycin inhibits RELA. 2 / 2

| 2

---

➶

reach

"17-DMAG suppresses NFkappaB p65 activity."

24694060

---

➶

reach

"Our results revealed that the addition of 17-DMAG dose-dependently suppressed NFkappaB p65 activity without affecting its protein level."

24694060

Aluminium(3+) affects CASP1

| 2

Aluminium(3+) inhibits CASP1. 2 / 2

| 2

---

➶

reach

"Conversely, intracellular caspase-1 activity was not significantly decreased by ALN."

29438662

---

➶

reach

"Pretreatment of cells with anti-ASC antibody prior to the addition of ALN suppressed IL-1beta production, suggesting the possibility that activation of ASC is involved in ALN augmented caspase-1 activation and release."

29438662

Allopurinol affects NLRP3

| 2

Allopurinol inhibits NLRP3. 2 / 2

| 2

---

➶

eidos

"Moreover , allopurinol , an inhibitor of XO , reduced NLRP3 expression ."

32508525

---

➶

eidos

"Allopurinol significantly inhibited NLRP3 expression ."

32508525

All-trans-retinoic acid affects NFKBIA

| 2

All-trans-retinoic acid inhibits NFKBIA. 2 / 2

| 2

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➶

reach

"In contrast, ATRA did not degrade the IkappaBalpha in cytosol of SH5Y ShTG2 cells compared with SH-5Y Shcon cells (XREF_FIG C)."

24130925

---

➶

reach

"In XREF_FIG B, IkappaBalpha level in the cytosolic fraction was not decreased by ATRA, while ATRA clearly decreased IkappaBalpha in the whole cell lysates (XREF_FIG A)."

24130925

All-trans-retinoic acid affects IRF7

| 2

All-trans-retinoic acid inhibits IRF7. 2 / 2

| 2

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➶

reach

"Moreover, either ATRA or Pin1 knockdown significantly suppressed R848 induced IRF-7 transactivation, as shown by the luciferase reporter assay (XREF_FIG), and also blocked R848 induced nuclear translocation of IRF-7, as shown by immunostaining (XREF_FIG)."

27159270

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➶

reach

"As shown in XREF_FIG, ATRA at 5 muM effectively induced Pin1 degradation, suggesting that ATRA might inhibit Pin1 dependent IRAK-1 and IRF-7 signaling."

27159270

All-trans-retinoic acid affects FOS

| 2

All-trans-retinoic acid inhibits FOS. 2 / 2

| 2

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➶

reach

"ATRA also abolished increases of the transcription factors c-Fos and NFAT2 stimulated by RANKL and suppressed down-regulation of the antiosteoclastogenic transcription factor MafB."

19546303

---

➶

reach

"ATRA abolished an increase in the transcription factors c-Fos and the nuclear factor of activated T cells (NFAT) NFAT2 stimulated by RANKL and suppressed down-regulation of the anti-osteoclastogenic transcription factor MafB [XREF_BIBR]."

22471523

Agmatine affects NLRP3

| 2

Agmatine inhibits NLRP3. 2 / 2

| 2

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➶

reach

"Stress reduced levels of IL-4 and IL-10, two major anti-inflammatory cytokines, were restored back to normal by agmatine treatment in the PFC. The findings of the present study suggest that stress activated NLRP3 inflammasome and cytokine responses are reversed by an acute administration of agmatine."

27061450

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➶

reach

"Agmatine significantly down-regulated the gene expressions of all stress induced NLRP3 inflammasome components (NLRP3, NF-kappaB, PYCARD, caspase-1, IL-1beta and IL-18) in the hippocampus and prefrontal cortex (PFC) and reduced pro inflammatory cytokine levels not only in both brain regions, but also in serum."

27061450

Adenosine affects FOS

| 2

Adenosine inhibits FOS. 2 / 2

| 2

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reach

"Increasing the stationary concentration of UVB induced DNA breaks by inhibition of repair in the presence of the adenosine diphosphoribose (ADPR)-transferase inhibitor 3-amino-benzamide suppressed the induction of c-fos."

8413289

---

➶

reach

"Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant induced arthritis."

12668251

Acetylsalicylic acid affects STING1

| 2

Acetylsalicylic acid inhibits STING1. 2 / 2

| 2

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reach

"Aspirin and dipyridamole, besides their anti-platelet activity, also reduce tissue factor procoagulant activity, and aspirin inhibits the STING pathway upstream of STING."

32574107

---

➶

reach

"Aspirin and dipyridamole, besides their anti-platelet activity, also reduce tissue factor procoagulant activity, and aspirin inhibits the STING pathway upstream of STING."

32574107

Acetylsalicylic acid affects RELA

1 | 1

Acetylsalicylic acid inhibits RELA. 2 / 2

1 | 1

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➶

medscan

"We observed that aspirin inhibits A549 cell migration by suppressing p65NFκB activation and translocation to the nucleus for binding to SLUG promoter, thereby resulting in the transcriptional down-regulation of Slug in these non-small cell lung carcinoma cells."

26810856

---

➶

ctd

No evidence text available

20137092

Acetylcholine affects MYD88

| 2

Acetylcholine inhibits MYD88. 2 / 2

| 2

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➶

reach

"We observed that both nicotine and ACh reduced MALP-2-mediated MyD88 production by ~ 42%."

26071220

---

➶

reach

"We observed that both nicotine and ACh reduced MALP-2-mediated MyD88 production by ~ 42% (XREF_FIG)."

26071220

Abacavir affects RELA

| 2

Abacavir inhibits RELA. 2 / 2

| 2

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➶

reach

"Treatment of three BCR dependent ABC DLBCL lines with birinapant decreased the nuclear abundance of NF-kappaB dimers containing the p65 subunit, indicating that cIAP1/2 contribute to classical NF-kappaB activity in these cells."

27070702

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➶

reach

"Treatment of three BCR dependent ABC DLBCL lines with birinapant decreased the nuclear abundance of NF-kappaB dimers containing the p65 subunit, indicating that cIAP1/2 contribute to classical NF-kappaB activity in these cells (XREF_FIG)."

27070702

[4-[[4-(1-benzothiophen-2-yl)-2-pyrimidinyl]amino]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone affects IKBKB

2 |

[4-[[4-(1-benzothiophen-2-yl)-2-pyrimidinyl]amino]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone inhibits IKBKB. 2 / 2

2 |

---

➶

tas

No evidence text available

23501112

---

➶

tas

No evidence text available

16236504

[11C]-SORAFENIB affects MAP3K7

2 |

[11C]-SORAFENIB inhibits MAP3K7. 2 / 2

2 |

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➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

Val-Ile affects JAK1

| 1 1

Val-Ile inhibits JAK1. 2 / 2

| 1 1

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➶

sparser

"Since JAK3 inhibitor VI can also efficiently inhibit JAK1 and JAK2 ( xref ), we depleted JAK1 and JAK2 from SK‐OV3.ip1 cells ( xref ) and studied its effect on lysosomal distribution ( xref A) and zFRase activity using CTSB and ERBB2 siRNAs as positive controls ( xref B)."

25070180

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➶

reach

"Since JAK3 inhibitor VI can also efficiently inhibit JAK1 and JAK2 (Anastassiadis etal., 2011), we depleted JAK1 and JAK2 from SK-OV3."

25070180

Val-Asp affects RELA

| 2

Val-Asp inhibits RELA. 2 / 2

| 2

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➶

reach

"In human lymphocytes, VD 3 suppressed NFkappaB p50 and its precursor proteins p105 and p65 (Yu et al., 1995)."

17521736

---

➶

reach

"Here, we found that VD (3) strongly repressed p65 transactivation in MCF-7 cells using Gal4-p65 chimeras system."

20371119

Val-Asp affects NFKBIA

| 2

Val-Asp inhibits NFKBIA. 2 / 2

| 2

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➶

reach

"Both SITO and VD also induced IkappaBalpha degradation in BEAS-2B cells (XREF_FIG), suggesting that the particle induced NFkappaB activation may not be cell type specific."

25874458

---

➶

reach

"Western blotting densitometry revealed that SnO 2, SITO, and VD caused significant IkappaBalpha protein level reductions at 3 h post-treatment in RAW cells (XREF_FIG)."

25874458

Val-Asp affects NFKB1

| 2

Val-Asp inhibits NFKB1. 2 / 2

| 2

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➶

reach

"In human lymphocytes, VD 3 suppressed NFkappaB p50 and its precursor proteins p105 and p65 (Yu et al., 1995)."

17521736

---

➶

reach

"In human lymphocytes, VD 3 suppressed NFkappaB p50 and its precursor proteins p105 and p65 (Yu et al., 1995)."

17521736

Val-Ala affects ITCH

| 2

Val-Ala inhibits ITCH. 2 / 2

| 2

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➶

reach

"Both VA and cetirizine significantly reduced type I hypersensitivity itch in patients with AD, compared with both placebo and NI."

22313287

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➶

reach

"Both VA and cetirizine significantly reduced type-I-hypersensitivity itch in AD patients, compared to both placebo and NI."

22313287

Trypsin affects DDX58

| 2

Trypsin inhibits DDX58. 2 / 2

| 2

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➶

reach

"This observation suggests that the 80-kDa RIG-I fragment indeed represents the trypsin resistance of a RIG-I : RNA complex."

27651356

---

➶

reach

"We therefore hypothesized that the 80-kDa fragment represented the trypsin resistance of a RIG-I : RNA complex involving helicase domain interactions."

27651356

Trp-Leu-Leu affects FOS

| 2

Trp-Leu-Leu inhibits FOS. 2 / 2

| 2

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➶

reach

"WLL suppressed osteoclastogenesis and bone resorption by RANKL in a concentration dependent manner by modulating the NFATc and c-fos pathway in vitro, and wLL inhibited bone loss in the OVX induced osteoporosis model in vivo."

30915145

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➶

reach

"These results mean that wLL inhibit the differentiation, activation, and bone resorption of mature osteoclasts as well as the formation of multinucleated osteoclasts by cell-cell fusion via block of c-fos and NFATc -1 pathway in RANKL induced osteoclastogenesis."

30915145

Thalidomide affects NFKB1

2 |

Thalidomide inhibits NFKB1. 2 / 2

2 |

---

➶

drugbank

No evidence text available

15723633

---

➶

drugbank

No evidence text available

11752352

TUDCA affects CASP1

| 2

TUDCA inhibits CASP1. 2 / 2

| 2

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➶

reach

"Treatment with TUDCA, a molecular chaperone that alleviates ER stress, and 4μ8C, IRE1α inhibitor that selectively inactivates RNase activity, decreased Bid truncation, caspase-2 and caspase-1 cleavages, and IL-1β production in RB51-infected or ER stress inducer-treated BMDM, but not LPS + ATP-treated BMDM [41]."

29849928

---

➶

reach

"It was found that TUDCA treatment could repress BSA induced activation of caspase-1 as determined by immunoblotting for the active p10 subunit as shown in XREF_FIG."

23977286

TOZASERTIB LACTATE affects TBK1

2 |

TOZASERTIB LACTATE inhibits TBK1. 2 / 2

2 |

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➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

Sunitinib affects MAP3K7

2 |

Sunitinib inhibits MAP3K7. 2 / 2

2 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

19654408

Shikonin affects PYCARD

| 2

Shikonin inhibits PYCARD. 2 / 2

| 2

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reach

"Our data, however, demonstrated that shikonin inhibits inflammasome activation by dampening the formation of ASC specks and by directly inhibiting caspase-1."

27467658

---

➶

reach

"Shikonin Inhibits Formation of ASC Specks and Directly Targets Caspase-1."

27467658

Ser-Ala affects IKBKB

| 2

Ser-Ala inhibits IKBKB. 2 / 2

| 2

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➶

reach

"Inhibition of IKK-beta, in addition to inhibition of PTP1B, in mice treated with the SA compounds, could be a possible mechanism of the compound 's biological response including the resistance to diet induced weight gain and improvement in blood parameters."

20044255

---

➶

reach

"SA has been reported to inhibit IKKbeta and has been shown to inhibit TNF-alpha in human mononuclear cells when DMXAA is combined with anti-CD14 antibodies or deacylated LPS."

17562815

Ser-Ala affects IFNB1

| 1 1

Ser-Ala inhibits IFNB1. 2 / 2

| 1 1

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➶

sparser

"SA selectively inhibits DMXAA-induced IFN-β."

17562815

---

➶

reach

"SA selectively inhibits DMXAA induced IFN-beta."

17562815

SUNITINIB MALATE affects MAP3K7

2 |

SUNITINIB MALATE inhibits MAP3K7. 2 / 2

2 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

19654408

SU-014813 affects JAK1

2 |

SU-014813 inhibits JAK1. 2 / 2

2 |

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

SU-014813 affects IKBKE

2 |

SU-014813 inhibits IKBKE. 2 / 2

2 |

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

SC-58125 affects RELA

| 2

SC-58125 inhibits RELA. 2 / 2

| 2

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reach

"SC-58125 attenuated both poly (I : C) - and MALP-2-induced RelA and p65 nuclear localization (XREF_FIG), suggesting that Cox-2 inhibitors abrogate NF-kappaB activation."

20971925

---

➶

reach

"SC-58125 attenuated both poly (I : C) - and MALP-2-induced RelA and p65 nuclear localization (XREF_FIG), suggesting that Cox-2 inhibitors abrogate NF-kappaB activation."

20971925

SC-236 affects RELA

2 |

SC-236 inhibits RELA. 2 / 2

2 |

---

➶

drugbank

No evidence text available

15784648

---

➶

drugbank

No evidence text available

12606945

SB202190 affects JUN

| 2

SB202190 inhibits JUN. 2 / 2

| 2

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➶

reach

"Furthermore, Stxs induced mRNA of the primary response gene c-jun, which was subsequently partially blocked by SB202190."

10531258

---

➶

reach

"Further, the inhibitors SB202190 (Sigma-Aldrich) and SP600125 (Sigma-Aldrich) were used to block p38 mitogen activated protein kinase (p38-MAPK) and Jun N-terminal kinase (JNK) respectively in control and siPrdx2 transfected HTR8 cells."

28661480

SB-284851-BT affects MAPK14

2 |

SB-284851-BT inhibits MAPK14. 2 / 2

2 |

---

➶

tas

No evidence text available

17706839

---

➶

tas

No evidence text available

11354358

SB-245391 affects MAPK14

2 |

SB-245391 inhibits MAPK14. 2 / 2

2 |

---

➶

tas

No evidence text available

11354358

---

➶

tas

No evidence text available

17706839

SB-242235 affects MAPK8

2 |

SB-242235 inhibits MAPK8. 2 / 2

2 |

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

11597418

SB-239063 affects MAPK8

2 |

SB-239063 inhibits MAPK8. 2 / 2

2 |

---

➶

tas

No evidence text available

11597418

---

➶

tas

No evidence text available

SB-239063 affects MAPK14

2 |

SB-239063 inhibits MAPK14. 2 / 2

2 |

---

➶

tas

No evidence text available

18077363

---

➶

tas

No evidence text available

11597418

SB-202190 affects STAT1

| 2

SB-202190 inhibits STAT1. 2 / 2

| 2

---

➶

medscan

"Activation of the p38MAPK pathway by upstream activating kinase, MKK6 (MAPK kinase-6) or osmotic stress enhanced the SUMOylation of STAT1, which was counteracted by the p38MAPK inhibitor SB202190 or by dominant-negative p38MAPK."

17897103

---

➶

medscan

"The p38 MAPK inhibitor SB202190 suppressed IL-1beta- and IL-1beta plus leptin-induced hBD-2 production, IL-1beta-induced nuclear factor-kappaB activity, and leptin-induced STAT1 and STAT3 activity; contrastingly, the Janus kinase 2 inhibitor AG490 suppressed IL-1beta plus leptin-induced hBD-2 production and leptin-induced STAT1 and STAT3 activity."

18556347

SB 203580 affects TRAF3

| 2

SB 203580 inhibits TRAF3. 2 / 2

| 2

---

➶

reach

"SB203580 also inhibits c-Jun-N-terminal kinase 2 (JNK2) and the kinase c-Raf1, albeit with significantly higher IC 50 values than p38alpha and beta."

27136566

---

➶

reach

"These data suggest that if SB203580 does inhibit c-Raf1 in vivo, such a compensatory effect would be activated, leading to little effect on growth."

27136566

SB 203580 affects STAT1

| 1 1

SB 203580 inhibits STAT1. 2 / 2

| 1 1

---

➶

medscan

"In addition, streptococcal pyrogenic exotoxin B and G308S increased binding of serine-phosphorylated STAT1 to the Bax promoter and Bax expression, which was decreased by SB203580."

19801665

---

➶

reach

"PathwayNet analysis suggested that UM101 inhibits some of the SB203580 inhibited transcription factors (STAT-1, c-Fos, c-Jun, NF-kappaB, p53, PPARgamma, and Sp1), but not others (ATF1, ATF2, Elk1, c/EBPbeta, USF1, SMAD3, FOXO1, and CREB via MSK1/2)."

28298524

SB 203580 affects NFKB1

| 2

SB 203580 inhibits NFKB1. 2 / 2

| 2

---

➶

reach

"HBV DNA load was maximal when the JNK pathway was blocked with SP600125 even when TLR7 was stimulated as compared to the other blockers PDTC, LY294002 and SB203580 which blocked NF-KB, PI3K and p38 pathway respectively."

28088184

---

➶

reach

"As shown in XREF_FIG, 10muM SB203580 significantly decreased the nuclear NF-kappaB p50 signal after stimulation with Be."

25454621

SB 203580 affects MAP3K7

| 2

SB 203580 inhibits MAP3K7. 2 / 2

| 2

---

➶

reach

"Of interest, the p38 pathway inhibitor, SB203580, enhanced the antiviral effect of TAK1 on HBV replication (XREF_FIG, lane 6), consistent with a previous publication indicating that suppression of MAPK-p38 inhibits hepatitis B virus replication in human hepatoma cells XREF_BIBR."

28045080

---

➶

reach

"5Z-7-oxozeaenol and SB203580, which block TAK1 and p38 kinase respectively, abrogated the LTB4 inhibitory effect on L-type calcium channels."

26584289

SB 203580 affects CASP1

| 2

SB 203580 inhibits CASP1. 2 / 2

| 2

---

➶

reach

"SB203580 pretreatment greatly reduced caspase-1 and caspase-3 activities, as evidenced by decreased emission peaks of their fluorescent substrates."

10727463

---

➶

reach

"SB203580 pretreatment prevented activation of caspase-3 and caspase-1, and also suppressed the cleavage of poly (ADP) ribose polymerase."

10233770

SB 202190 affects MAPK14

1 | 1

SB 202190 inhibits MAPK14. 2 / 2

1 | 1

---

➶

reach

"Moreover, the pyridinyl-imidazole compounds SB 203580 and SB 202190 [41] inhibit SAPK2a and SAPK2b, but not SAPK3 and SAPK4 [24]."

9199504

---

➶

signor

No evidence text available

Other

S3I-201 affects STAT1

| 1 1

S3I-201 inhibits STAT1. 2 / 2

| 1 1

---

➶

eidos

"S3I-201 not only inhibits STAT3-STAT3 complex formation , STAT3-DNA binding and transcriptional activities , but also inhibits STAT1 and STAT5 ( 48 ) ."

32565984

---

➶

reach

"At the concentration of fludarabine (50 muM) and S31-201 (10 muM) that selectively inhibited STAT1 and STAT3, respectively (Fig XREF_FIG C), we found that STAT1 inhibitor fludarabine could reverse the inhibitory effects of IL-27 on the development of IL-17A-producing gammadelta T cells (Fig XREF_FIG D)."

24408967

S-butyl-DL-homocysteine (S,R)-sulfoximine affects JUN

2 |

S-butyl-DL-homocysteine (S,R)-sulfoximine inhibits JUN. 2 / 2

2 |

---

➶

ctd

No evidence text available

16259964

---

➶

ctd

No evidence text available

11849044

S-adenosyl-L-methioninate affects MYD88

| 2

S-adenosyl-L-methioninate inhibits MYD88. 2 / 2

| 2

---

➶

reach

"Moreover, TLR4 and MYD88 gene and protein expressions were downregulated by SAM pretreatment in LPS stimulated KCs."

26202509

---

➶

reach

"Simultaneously, SAM also attenuated LPS induced liver injury and expression of TLR4 and MYD88 in the hepatic sinusoid."

26202509

Ruxolitinib affects JAK1

2 |

Ruxolitinib inhibits JAK1. 2 / 2

2 |

---

➶

drugbank

No evidence text available

23514013

---

➶

drugbank

No evidence text available

23061804

RUBOXISTAURIN affects TBK1

2 |

RUBOXISTAURIN inhibits TBK1. 2 / 2

2 |

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

22037378

RES affects RELA

| 2

RES inhibits RELA. 2 / 2

| 2

---

➶

reach

"Consistently, RES has been found to suppress the activity of the downstream transcription factors AP-1 and nuclear factor-kappaB (RelA and p65)."

25663913

---

➶

reach

"Consistently, RES has been found to suppress the activity of the downstream transcription factors AP-1 and nuclear factor-kappaB (RelA and p65)."

25663913

R-1487 affects MAPK8

2 |

R-1487 inhibits MAPK8. 2 / 2

2 |

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

21375264

R-1487 affects MAPK14

1 1 |

R-1487 inhibits MAPK14. 2 / 2

1 1 |

---

➶

tas

No evidence text available

21375264

---

➶

drugbank

No evidence text available

21375264

Poly I:C affects IFNB1

| 2

Poly I:C inhibits IFNB1. 2 / 2

| 2

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➶

reach

"Poly I : C triggered IFN-beta was significantly reduced by 500 U/mL to 1000 U/mL of the IFN-beta neutralizing Ab, and it was suppressed in the presence of a higher concentration (2000 U/mL) (XREF_FIG A)."

22754655

---

➶

reach

"Poly I : C induced IFNbeta, TNFalpha, IL-8 and IL-10 is reduced by activation of Fas, whilst IP-10 is augmented."

25849666

Phe-Asp affects MAPK8

| 2

Phe-Asp inhibits MAPK8. 2 / 2

| 2

---

➶

reach

"In addition, there were four transcripts shared by all five sub-categories; NGFR was elevated, and FGF2, HGF and MAPK8 were all suppressed by FD."

24632812

---

➶

reach

"The transcripts regulating the protein kinases displayed a mixed expression profile; ALK, DLG2, KIT, NTRK3 and PRKCD were elevated, but MAPK8 and ROCK1 were suppressed by FD."

24632812

PYR41 affects ITCH

| 2

PYR41 inhibits ITCH. 2 / 2

| 2

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➶

reach

"We therefore did not follow up clomipramine.Performing IC 50 inhibition curves using the MALDI-TOF E2/E3 assay, we could show that PYR41 inhibited MDM2, ITCH, and HOIP at IC 50 values of 3.1, 11.3, and 5.7 muM."

30017913

---

➶

reach

"Performing IC 50 inhibition curves using the MALDI-TOF E2/E3 assay (XREF_FIG; XREF_SUPPLEMENTARY), we could show that PYR41 inhibited MDM2, ITCH, and HOIP at IC 50 values of 3.1, 11.3, and 5.7 muM."

30017913

PI-103 affects RELA

| 2

PI-103 inhibits RELA. 2 / 2

| 2

---

➶

reach

"Hence, PI-103 significantly decreases the fluorescence intensities of NFkappaB p65 in Lyn-knockdown 16HBE cells after the addition of IL-13."

28024734

---

➶

reach

"PI-103 also decreases the activity of NFkappaB p65."

28024734

PF-670462 free base affects MAPK14

2 |

PF-670462 free base inhibits MAPK14. 2 / 2

2 |

---

➶

tas

No evidence text available

23919824

---

➶

tas

No evidence text available

22168824

PF affects RELA

| 2

PF inhibits RELA. 2 / 2

| 2

---

➶

reach

"Taken together, our study reveals a mechanism underlying TNF-alpha-induced cell apoptosis : PF could inhibit the activity of NF-kappaBp65 and apoptosis of L929 cells induced by TNF-alpha, suggesting that PF may play a role in the treatment of RA through the antagonism of TNF-alpha pathway."

29887769

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➶

reach

"Our results showed that PF could inhibit activation of NF-kappaBp65, whereas NF-kappaBp65 may contribute to inflammatory related complex cellular pathways, and it is also one of the mechanisms of its therapeutic effect on RA (XREF_FIG)."

29887769

PF affects FOS

| 2

PF inhibits FOS. 2 / 2

| 2

---

➶

reach

"Here, we showed that PF inhibited NFATc1 and c-Fos transcriptional activity and expression at both protein and mRNA levels."

29459582

---

➶

reach

"PF treatment remarkably inhibited the key genes, NFATc1 and c-Fos."

29459582

Ondansetron affects ITCH

| 2

Ondansetron inhibits ITCH. 2 / 2

| 2

---

➶

reach

"Our results also demonstrated application of 5-HT 3 receptor antagonist ondansetron attenuated itch in BDL rats but not in sham rats."

27824106

---

➶

reach

"Ondansetron relieves itch caused by spinal opioids (but not cholestasis and uraemia)."

12509645

Ondansetron affects FOS

| 2

Ondansetron inhibits FOS. 2 / 2

| 2

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➶

reach

"Ondansetron attenuates CCK induced satiety and c-fos labeling in the dorsal medulla."

11457529

---

➶

reach

"Interestingly, they provide evidence that some satiety signals produced by intestinal nutrient infusion are CCK A-receptor mediated and some are independent, suggesting that other factors regulate satiety in the OLETF rats.One research article details the inhibitory effect of the 5HT3 antagonist ondansetron on CCK stimulated food intake and c-fos activation in the dorsal medulla."

11457511

Obacunone affects MAPK14

| 2

Obacunone inhibits MAPK14. 2 / 2

| 2

---

➶

medscan

"Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by inhibiting the p38 MAPK signaling pathway in MCF-7 human breast adenocarcinoma cells."

24927687

---

➶

medscan

"Furthermore, we found that obacunone inhibited COX-2 and nuclear factor-kappa B by activation of the p38 mitogen-activated protein kinase ."

24927687

OCLACITINIB MALEATE affects TYK2

2 |

OCLACITINIB MALEATE inhibits TYK2. 2 / 2

2 |

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

OCLACITINIB MALEATE affects JAK1

2 |

OCLACITINIB MALEATE inhibits JAK1. 2 / 2

2 |

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

Neflamapimod affects MAPK14

2 |

Neflamapimod inhibits MAPK14. 2 / 2

2 |

---

➶

drugbank

No evidence text available

10592235

---

➶

drugbank

No evidence text available

24900264

Nadroparin affects FOS

2 |

Nadroparin inhibits FOS. 2 / 2

2 |

---

➶

drugbank

No evidence text available

19261492

---

➶

drugbank

No evidence text available

19757196

NS-398 affects RELA

| 2

NS-398 inhibits RELA. 2 / 2

| 2

---

➶

reach

"NS-398 reduced IL-1beta-stimulated nuclear and cytoplasmic p65 to control levels."

17335379

---

➶

reach

"COX-2, and NF-kappaB p50 and p65 were down-regulated by NS398 in a concentration and time responsive manner (data not shown)."

14532848

NILOTINIB HYDROCHLORIDE MONOHYDRATE affects MAPK14

2 |

NILOTINIB HYDROCHLORIDE MONOHYDRATE inhibits MAPK14. 2 / 2

2 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

26789553

NADPH affects NLRP3

| 2

NADPH inhibits NLRP3. 2 / 2

| 2

---

➶

reach

"The lysosomal NADPH oxidase appeared to be a good candidate for the source of ROS and silencing NADPH oxidase reduced NLRP3 activation by asbestos and MSU."

25879282

---

➶

reach

"Mechanical ventilation induced NLRP3 inflammasome activation (XREF_FIG), release of IL-1beta (XREF_FIG, XREF_SUPPLEMENTARY, and XREF_FIG) and IL-18 (XREF_FIG and XREF_SUPPLEMENTARY) were significantly attenuated by pretreatment of mice with a mitochondrial ROS inhibitor, but not by depletion of NADPH oxidase derived ROS."

23436933

NAC affects MAPK8

| 2

NAC inhibits MAPK8. 2 / 2

| 2

---

➶

reach

"In addition, NAC significantly attenuated MCLR triggered testicular eIF2s1 and MAPK8 activation, indicating that NAC counteracts MCLR induced unfolded protein response (UPR) in testes."

29679867

---

➶

reach

"Free radical scavengers N -acetyl cysteine (NAC) and glutathione (GSH) inhibited ERK2 activation and, to a much lesser extent, JNK1 activation by tBHQ ⧸ BHA, implicating the role of oxidative stress in tBHQ induced ARE activation."

15038973

N-tosyl-L-phenylalanyl chloromethyl ketone affects IKBKB

| 1 1

N-tosyl-L-phenylalanyl chloromethyl ketone inhibits IKBKB. 2 / 2

| 1 1

---

➶

reach

"These results suggest that TPCK inhibits NF-kappaB activation by directly modifying thiol groups on two different targets : Cys 179 of IKKbeta and Cys 38 of p65 and RelA."

19591457

---

➶

trips

"Our data reveals for the first time that PDK1 and PKB may differentially activate NF-kappaB, and that TPCK may subserve a useful anti-inflammatory function by inhibiting IKKbeta."

17136479

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide affects TYK2

2 |

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide inhibits TYK2. 2 / 2

2 |

---

➶

tas

No evidence text available

21106455

---

➶

tas

No evidence text available

22037378

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide affects JAK1

2 |

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide inhibits JAK1. 2 / 2

2 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

21106455

N-nitrosodiethylamine affects FOS

| 2

N-nitrosodiethylamine inhibits FOS. 2 / 2

| 2

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➶

reach

"De Groot, R.P., Rijken, P.J., Den Hertog, J., Boonstra, J., Verkleij, A.J., De Laat, S.W. and Kruijer, W. (1990) Microgravity decreases c-fos induction and serum response element activity."

9026045

---

➶

reach

"De Groot R.P., Rijken, P., Den Hertog, J., and Boonstra, J. Microgravity decreases c-fos induction and serum response element activity."

9028534

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects NFKB1

| 2

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits NFKB1. 2 / 2

| 2

---

➶

reach

"Both 15d-PGJ 2 and MG132 inhibited IkappaB-alpha degradation and p105 processing in response to TNF-alpha in our experiments."

27833612

---

➶

reach

"We can not eliminate the possibility that MGl15 and MG132 inhibit p105 processing and h < Ba degradation by affecting some unidentified cell enzyme."

8087845

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects IRF7

| 2

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits IRF7. 2 / 2

| 2

---

➶

medscan

"Indeed, coexpression of wild-type RAUL but not the catalytic domain point mutant of RAUL, with IRF7 or IRF3 led to a loss of both proteins in a dose-dependent manner, which was prevented by treatment with the proteasome inhibitor MG132 ( )."

21167755

---

➶

medscan

"The NF-kappa B inhibitors MG132 and pyrrolidinedithiocarbamate efficiently inhibited the induction of IFN regulatory factor-7 by HSV or LPS, and also down-regulated the constitutive expression of IFN regulatory factor-7 in plasmacytoid dendritic cells and blocked the HSV-induced production of IFN-alpha."

15265881

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects IRF3

| 1 1

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits IRF3. 2 / 2

| 1 1

---

➶

reach

"Specifically, we find that significant IRF3 degradation can be observed in virus infected cells treated with MG132 for 24 hrs."

21677781

---

➶

medscan

"Indeed, coexpression of wild-type RAUL but not the catalytic domain point mutant of RAUL, with IRF7 or IRF3 led to a loss of both proteins in a dose-dependent manner, which was prevented by treatment with the proteasome inhibitor MG132 ( )."

21167755

N-acetyl-L-cysteine affects IKBKB

1 | 1

N-acetyl-L-cysteine inhibits IKBKB. 2 / 2

1 | 1

---

➶

reach

"Moreover, TNF-alpha-enhanced IKK-beta activity was also inhibited by (polyethylene glycol) PEG-catalase, N-acetylcysteine (NAC), and vitamin E."

25463279

---

➶

ctd

No evidence text available

17395010

N-acetyl-L-cysteinate affects STAT1

| 2

N-acetyl-L-cysteinate inhibits STAT1. 2 / 2

| 2

---

➶

reach

"For example, STAT-1 activated by the transition metal V 2 O 5 is blocked by anti-oxidants N-acetyl-L-cysteine or catalase [XREF_BIBR]."

20738867

---

➶

reach

"The antioxidant N-acetyl-L-cysteine reduced ROS production and STAT1 activity induced by AngII, indicating that AngII uses ROS as a second messenger to regulate STAT1 activity."

22217266

N-acetyl-L-cysteinate affects NLRP3

| 2

N-acetyl-L-cysteinate inhibits NLRP3. 2 / 2

| 2

---

➶

reach

"N-acetyl-l-cysteine (NAC), a reductant, inhibits NLRP3 activation in different models XREF_BIBR XREF_BIBR XREF_BIBR."

28084303

---

➶

reach

"The cell-permeable reducing agent dithiothreitol and the reactive oxygen species (ROS) inhibitor N-acetyl-L-cysteine (NAC) did not inhibit the hyperosmotic expression of the NLRP3 gene (XREF_FIG)."

27788256

N-acetyl-L-cysteinate affects JUN

| 2

N-acetyl-L-cysteinate inhibits JUN. 2 / 2

| 2

---

➶

reach

"N-acetyl-L-cysteine (NAC) treatment abolished both cell death and c-Jun activation induced by the combination treatments."

24750999

---

➶

reach

"This work investigated the capacity of alpha-lipoic acid (LA) and N-acetyl-L-cysteine (NAC) to reduce zinc deficiency induced oxidative stress, and prevent the activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), and the cross-talk between both activated cascades through beta-Transducin Repeat containing Protein (beta-TrCP)."

16298762

N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide affects TBK1

2 |

N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide inhibits TBK1. 2 / 2

2 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide affects MAPK14

2 |

N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide inhibits MAPK14. 2 / 2

2 |

---

➶

tas

No evidence text available

| DOI

---

➶

tas

No evidence text available

16162000

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide affects JUN

| 2

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide inhibits JUN. 2 / 2

| 2

---

➶

reach

"However, the treatment of H89 dramatically suppressed the promoter activity of Fra-1 or c-Jun induced by LMP1 in a dose dependent manner, resulting in their decreasing protein levels."

25958199

---

➶

reach

"Interestingly, we found that H-89 did not inhibit TPA induction of c-jun."

10535756

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide affects FOS

| 2

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide inhibits FOS. 2 / 2

| 2

---

➶

reach

"A 15 muM concentration of H-89 did not suppress serum induction of c-fos and c-jun mRNAs."

10535756

---

➶

reach

"In addiction, PKA inhibitor H89 also inhibits c-Fos induction in 3T3-AR7 cells by ACTH (39), implicating activation of the cAMP/PKA/CREB pathway in c-Fos induction by ACTH (39)."

16845490

N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoylethanolamine affects JUN

| 2

N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoylethanolamine inhibits JUN. 2 / 2

| 2

---

➶

reach

"Expression of the early response gene c-fos remained intact, but DHEA and 16 alpha-bromoepiandrosterone decreased DNA binding of the transcription factor activator protein-1, a later response important for expression of genes that mediate DNA synthesis and cell cycle progression."

9580639

---

➶

reach

"Rather, DHEA decreases the binding of the transcription factor activator protein-1, a later response important for expression of genes that mediate DNA synthesis and cell cycle progression [22]."

11226832

N-(3-oxododecanoyl)-L-homoserine lactone affects NLRP3

| 2

N-(3-oxododecanoyl)-L-homoserine lactone inhibits NLRP3. 2 / 2

| 2

---

➶

reach

"Moreover, 3-oxo-C12-HSL completely blocked the NLRP3 inflammasome activation in response to LPS and ATP stimulation."

28396663

---

➶

reach

"Similar to pyocyanin, two P. aeruginosa autoinducers showed no effect on the AIM2 dependent caspase-1 activation triggered by poly dA : dT transfection, indicating that 3-oxo-C12-HSL could suppress NLRC4 and NLRP3 inflammasome signaling."

28396663

N(omega),N(omega)-dimethyl-L-arginine affects NFKBIA

| 2

N(omega),N(omega)-dimethyl-L-arginine inhibits NFKBIA. 2 / 2

| 2

---

➶

reach

"It was demonstrated that ADMA induced IkappaBalpha degradation, increased nuclear RelA and P65 translocation, and promoted the binding of NF-kappaB to the VCAM-1 promoter."

23296075

---

➶

reach

"This was independent of total RelA and P65 levels and ADMA induced IkappaBalpha degradation."

23296075

MOMELOTINIB DIHYDROCHLORIDE affects JAK1

2 |

MOMELOTINIB DIHYDROCHLORIDE inhibits JAK1. 2 / 2

2 |

---

➶

tas

No evidence text available

| DOI

---

➶

tas

No evidence text available

19762238

Lys-Pro affects CASP1

| 2

Lys-Pro inhibits CASP1. 2 / 2

| 2

---

➶

reach

"In addition, KP significantly reduced caspase-1 activity in nasal mucosa tissue of AR mice."

24056122

---

➶

reach

"KP significantly inhibited the production of interleukin (IL) -32 and IL-8 and activation of caspase-1 in Eol-1 cells."

24056122

Lys-Phe affects JUN

| 2

Lys-Phe inhibits JUN. 2 / 2

| 2

---

➶

reach

"In agreement with this result, KF suppressed the nuclear levels of major transcription factors (c-Jun at 30, 60, and 120min; c-Fos at 30 and 60min; p65 at 15, 30, and 60min; and p50 at 120min) in LPS treated RAW264.7 cells (XREF_FIG left panel)."

25922567

---

➶

reach

"KF reduced NF-kappaB (p65 and p50) and AP-1 (c-Jun and c-Fos) levels in the nucleus and their transcriptional activity."

25922567

Leu-Val-Ser affects JUN

| 2

Leu-Val-Ser inhibits JUN. 2 / 2

| 2

---

➶

reach

"showed that LVS is able to rapidly downregulate the initial activation of p38 and c-Jun, and hence cytokine secretion and that IglC is critical for this process."

21687753

---

➶

reach

"Also the LPS- or BLP induced phosphorylation of the mitogen activated protein kinase p38 and the transcription factor c-Jun was inhibited by F. tularensis LVS but not by the 23 kDa protein mutant."

12542469

Leu-Thr affects JUN

| 2

Leu-Thr inhibits JUN. 2 / 2

| 2

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➶

reach

"Here we identify COP1 as the ubiquitin E3 ligase that is essential for LT induced c-Jun degradation."

32041890

---

➶

reach

"COP1 knockdown using siRNA prevents degradation of c-Jun, ETV4, and ETV5 in cells treated with either LT or the MEK1/2 inhibitor, U0126."

32041890

Leu-Cys affects NLRP3

| 2

Leu-Cys inhibits NLRP3. 2 / 2

| 2

---

➶

reach

"However, since GPR120 signaling was only partially responsible for the LC n-3 PUFA mediated inhibition of NLRP3 inflammasome activity [XREF_BIBR], another mechanism must be involved."

29186929

---

➶

reach

"Recent evidence suggests that dietary fatty acids can modulate NLRP3 inflammasome activity, which is suppressed by LC n-3 PUFA in particular."

29186929

Leu-Cys affects NFKB1

| 2

Leu-Cys inhibits NFKB1. 2 / 2

| 2

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➶

reach

"We also found that NFkB and Akt phophorylation was partly inhibited by LC supplementation."

19328229

---

➶

reach

"The effect produced by CDNC could be due to the combined effects of both chromium and L-cysteine (LC) because LC supplementation independently also inhibited NFkB activation and improved insulin signaling."

20306473

LY294002 affects STAT1

| 1 1

LY294002 inhibits STAT1. 2 / 2

| 1 1

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➶

reach

"In addition, although LY294002 was not able to reduce STAT1 activation, we found that the mammalian target of rapamycin (mTOR)/p70 S6 kinase pathway was significantly attenuated by inhibition of the PI3K and Akt signaling pathway."

21430412

---

➶

medscan

"Inhibitors of STAT1, mitogen activated protein kinase kinase (MEK) (PD98059), and phosphatidyl inositol 3 kinase (LY294002), blocked gp120-induced STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120-induced monocyte adhesion and migration across in vitro blood-brain barrier models. 4999998={CellProcess=4116477 CellType=10000095}}"

19103208

LY294002 affects NFKB1

1 | 1

LY294002 inhibits NFKB1. 2 / 2

1 | 1

---

➶

ctd

No evidence text available

21173233

---

➶

reach

"HBV DNA load was maximal when the JNK pathway was blocked with SP600125 even when TLR7 was stimulated as compared to the other blockers PDTC, LY294002 and SB203580 which blocked NF-KB, PI3K and p38 pathway respectively."

28088184

LY294002 affects IRF3

| 2

LY294002 inhibits IRF3. 2 / 2

| 2

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➶

reach

"LY294002, a phosphatidylinositol 3-kinase inhibitor, inhibits IRF-3 dimerization and transcriptional activity [60,61]."

27468646

---

➶

reach

"The finding that IRF3 dependent IP-10 production was inhibited by either LY294002 or wortmannin suggests that the PI3K pathway is affected by L19 involvement."

21860608

LSM-1231 affects TYK2

2 |

LSM-1231 inhibits TYK2. 2 / 2

2 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

19654408

LSM-1231 affects TBK1

2 |

LSM-1231 inhibits TBK1. 2 / 2

2 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

LSM-1231 affects MAPK8

2 |

LSM-1231 inhibits MAPK8. 2 / 2

2 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

LSM-1231 affects MAP3K7

2 |

LSM-1231 inhibits MAP3K7. 2 / 2

2 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

19654408

LSM-1231 affects JAK1

2 |

LSM-1231 inhibits JAK1. 2 / 2

2 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

LSM-1231 affects IKBKE

2 |

LSM-1231 inhibits IKBKE. 2 / 2

2 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

19654408

LSM-1231 affects IKBKB

2 |

LSM-1231 inhibits IKBKB. 2 / 2

2 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

19654408

LSM-1231 affects CHUK

2 |

LSM-1231 inhibits CHUK. 2 / 2

2 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

LSM-1221 affects TBK1

2 |

LSM-1221 inhibits TBK1. 2 / 2

2 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

LSM-1221 affects MAP3K7

2 |

LSM-1221 inhibits MAP3K7. 2 / 2

2 |

---

➶

tas

No evidence text available

19654408

---

➶

tas

No evidence text available

22037378

LPS with O-antigen affects NFKB1

| 2

LPS with O-antigen inhibits NFKB1. 2 / 2

| 2

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➶

reach

"Lipopolysaccharide induced NFkB activity was not suppressed in cells transfected with the IRAK3 mutant with reduced cGMP generating capacity."

31664109

---

➶

reach

"Administration of NAC to rats reduced endotoxin induced NF-KB activation in lung tissue and neutrophil- mediated lung inflammation [23]."

9265727

L-serine affects PYCARD

| 2

L-serine inhibits PYCARD. 2 / 2

| 2

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➶

reach

"MeAIB is selective inhibitor of system A while L-Ala and L-Ser are inhibitors of system ASC."

21220129

---

➶

reach

"Na (+)-dependent L-alanine transport, but not MeAIB transport, was partially inhibited by L-serine and L-cysteine, indicating the participation of system ASC."

11171637

L-prolylglycine affects IFIH1

| 2

L-prolylglycine inhibits IFIH1. 2 / 2

| 2

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➶

reach

"Jones et al. [XREF_BIBR] recently showed that in mouse bone marrow derived mDCs, a form of Pg highly selective for iPRs (norgestrel) could inhibit TLR3 and Mda5- but not TLR4 activated up-regulation of CD40, indicating Pg may also selectively suppress pathways involved in CD4 + T cell responses after virus infection."

22193289

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➶

reach

"Pg failed to inhibit the Mda-5 pathway of IFN-alpha induction in dendritic cells, suggesting that Pg regulates select antiviral DC programs."

18250406

L-kynurenine affects FOS

| 2

L-kynurenine inhibits FOS. 2 / 2

| 2

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➶

reach

"Systemic kynurenine + probenecid treatment significantly diminishes nitroglycerin induced increase of c-fos immunoreactivity in the brainstem."

16897600

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➶

reach

"Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice."

26136670

L-dehydroascorbic acid affects CHUK

| 2

L-dehydroascorbic acid inhibits CHUK. 2 / 2

| 2

---

➶

medscan

"We discovered that dehydroascorbic acid directly inhibits IkappaBalpha kinase beta (IKKbeta) and IKKalpha enzymatic activity in vitro, whereas ascorbic acid did not have this effect."

15254232

---

➶

medscan

"ascorbic acid quenches Reactive oxygen species intermediates involved in the activation of NF-kappaB and is oxidized to dehydroascorbic acid, which directly inhibits IKKbeta and IKKalpha enzymatic activity."

15254232

L-cysteine affects NLRP3

| 2

L-cysteine inhibits NLRP3. 2 / 2

| 2

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➶

reach

"Although it can not be distinguished whether BOT-4-one directly promoted NLRP3 ubiquitination or inhibited the deubiquitination process of NLRP3, this PKA independent enhancement of NLRP3 ubiquitination could be due to NLRP3 alkylation, as it was also induced by other NLRP3 alkylators, Bay11-7082 and MNS, and efficiently blocked by L-cysteine."

29118366

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➶

reach

"However, it can be reasonably regarded that the observed enhancement of ubiquitination was attributed to the NLRP3 alkylation, as other known NLRP3 alkylators showed the same functionality and can be commonly inhibited by L-cysteine."

29118366

L-ascorbic acid affects NLRP3

| 2

L-ascorbic acid inhibits NLRP3. 2 / 2

| 2

---

➶

reach

"Indeed, vitamin C, vitamin D, and omega-3 fatty acids have all been shown to inhibit the NLRP3 inflammasome and may work synergistically against the cytokine storm associated with COVID-19 and specifically against the neuro inflammation associated with its delirium."

| PMC

---

➶

reach

"* Vitamin C : Like flavonoids, ascorbic acid inhibits NLRP3 inflammasome activation."

32229082

L-alanyl-L-alanine affects MAP3K7

| 2

L-alanyl-L-alanine inhibits MAP3K7. 2 / 2

| 2

---

➶

sparser

"The correlation between VopZ aa 38–62 dependent inhibition of TAK1 in vitro, aa 38–62 dependent diarrhea and other intestinal pathology in vivo, and the previously described consequences of intestinal TAK1 deficiency strongly suggests that inhibition of TAK1 activation by VopZ is a critical facet of V. parahaemolyticus pathogenicity."

23623501

---

➶

sparser

"The correlation between VopZ aa 38–62 dependent inhibition of TAK1 in vitro, aa 38–62 dependent diarrhea and other intestinal pathology in vivo, and the previously described consequences of intestinal TAK1 deficiency strongly suggests that inhibition of TAK1 activation by VopZ is a critical facet of V. parahaemolyticus pathogenicity."

23623501

KT 5720 affects CASP1

| 2

KT 5720 inhibits CASP1. 2 / 2

| 2

---

➶

reach

"XREF_FIG & XREF_FIG show that the competitive PKA inhibitor KT5720 prevents adenosine-dependent-activation of caspase 1 and that caspase-1 activation is reliant on the A2A AR."

24907587

---

➶

reach

"The PKA inhibitor KT5720 blocks activation of caspase-1 by adenosine."

24907587

JQ1 affects IFNB1

| 2

JQ1 inhibits IFNB1. 2 / 2

| 2

---

➶

reach

"Similar to the TLR3-TBK1-IRF3 pathway, we found that BI-2536, JQ1 and I-BET151 blocked the TLR7- or TLR9 stimulated secretion of IFNbeta in Gen2.2 cells (XREF_FIG A and XREF_FIG B), without affecting the TLR stimulated translocation of the endogenous IRF5 to the nucleus (XREF_FIG C)."

25891802

---

➶

reach

"Since BI-2536 and JQ1 blocked IFNbeta production by preventing the interaction of transcription factors with the Ifnb promoter, it was of interest to examine the effects of these compounds on the transcription of other poly (I : C) - and LPS regulated genes."

25891802

JNJ-49095397 affects MAPK14

2 |

JNJ-49095397 inhibits MAPK14. 2 / 2

2 |

---

➶

tas

No evidence text available

---

➶

tas

No evidence text available

26800309

Interferon beta-1a affects IFNAR2

2 |

Interferon beta-1a inhibits IFNAR2. 2 / 2

2 |

---

➶

drugbank

No evidence text available

11747625

---

➶

drugbank

No evidence text available

16912135

Interferon alfa-2a affects IFNAR2

2 |

Interferon alfa-2a inhibits IFNAR2. 2 / 2

2 |

---

➶

drugbank

No evidence text available

15898717

---

➶

drugbank

No evidence text available

18230610

Interferon alfa-2a affects IFNAR1

2 |

Interferon alfa-2a inhibits IFNAR1. 2 / 2

2 |

---

➶

drugbank

No evidence text available

18230610

---

➶

drugbank

No evidence text available

15898717

Hydroxychloroquine affects TLR7

2 |

Hydroxychloroquine inhibits TLR7. 2 / 2

2 |

---

➶

drugbank

No evidence text available

18220957

---

➶

drugbank

No evidence text available

14579285

Histone affects RELA

| 2

Histone inhibits RELA. 2 / 2

| 2

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➶

reach

"Based on these combined results, it appears that acetylation is required for maximal activity of p65, which is consistent with results showing that overexpression of CBP and p300 enhances the activation potential of p65, whereas overexpression of histone deacetylases (HDAC) represses p65 activity."

28334776

---

➶

reach

"We previously reported that the epigenetic signature requires induction of NF-kappaB factor RelB, which directs histone H3K9 dimethylation, disrupts assembly of transcription activator NF-kappaB p65, and induces a sustained switch from the euchromatin to heterochromatin."

19158276

Histone affects NLRP3

| 2

Histone inhibits NLRP3. 2 / 2

| 2

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➶

reach

"This inhibition is mediated not only through reduction of the release of extracellular histones in the lung but also through direct blockage of extracellular histone induced activation of the NLRP3 inflammasome."

29104591

---

➶

reach

"Recent work has elucidated an array of signaling functions of BHB : inhibitor of the NLRP3 inflammasome, inhibitor of histone deacetylases, ligand of G protein coupled receptors, and a covalent histone modification associated with fasting activated genes."

28877458

His-Met affects NFKBIA

| 2

His-Met inhibits NFKBIA. 2 / 2

| 2

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➶

reach

"NF-kappaB activation was further confirmed by p65 immunohistochemistry (XREF_FIG) and immunoblot (XREF_FIG) demonstrating p65 translocation, p65-S536 phosphorylation and IkappaBalpha degradation in HSCs treated with conditioned media from HM but not after treatment with control media."

23553591

---

➶

reach

"We found that HM induced the degradation of IkappaBalpha, a key step in the activation of NF-kappaB."

19103478

HDL affects TICAM1

| 2

HDL inhibits TICAM1. 2 / 2

| 2

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➶

reach

"To determine whether these transporters are involved when HDL suppresses genes in the TRAM and TRIF dependent pathway, we downregulated ABCA1 and ABCG1, using siRNA (XREF_FIG)."

20974999

---

➶

reach

"This suggests that HDL can inhibit both the MyD88 and TRAM and TRIF actions of TLR4 activation."

21864714

HDL affects NFKBIA

| 2

HDL inhibits NFKBIA. 2 / 2

| 2

---

➶

medscan

"Pretreatment with antibody against oxidized low-density lipoprotein receptor-1 (LOX-1) significantly suppressed the oxidized high-density lipoprotein-induced downregulation of I kappa B alpha, suggesting that LOX-1 mediates nuclear factor-kappa B activation in endothelial cells stimulated with oxidized high-density lipoprotein."

12646204

---

➶

medscan

"Treatment for 7h with 100 microg/ml oxidized high-density lipoprotein elicited a marked downregulation of I kappa B alpha and upregulation of the phosphorylated form of I kappa B alpha in human umbilical vein endothelial cells in a manner dependent on the dose of oxidized high-density lipoprotein."

12646204

HDL affects MYD88

| 2

HDL inhibits MYD88. 2 / 2

| 2

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➶

reach

"In contrast, HDL pretreatment failed to significantly suppress MyD88 dependent pathway genes, such as Tnf-alpha, Il-6, and Il-1beta (XREF_FIG)."

20974999

---

➶

reach

"This suggests that HDL can inhibit both the MyD88 and TRAM and TRIF actions of TLR4 activation."

21864714

Guo affects STAT1

| 2

Guo inhibits STAT1. 2 / 2

| 2

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➶

reach

"Likewise, Guo et al. (Guo et al., 2016) reported that PEDV infection induces ubiquitin-proteasome degradation of STAT1, leading to the downregulation of IFN-mediated response."

| PMC

---

➶

reach

"Likewise, Guo et al. (2016) reported that PEDV infection induces ubiquitin-proteasome degradation of STAT1, leading to the downregulation of IFN-mediated response."

| PMC

Guggulsterone affects IRF3

| 2

Guggulsterone inhibits IRF3. 2 / 2

| 2

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reach

"Guggulsterone inhibited nuclear factor-kappaB and IRF3 activation induced by lipopolysaccharide or poly [I : C] and activation of IRF3 induced by the overexpression of TRIF, TBK1 or constitutively active IRF3."

19000789

---

➶

reach

"Guggulsterone suppresses the activation of transcription factor IRF3 induced by TLR3 or TLR4 agonists."

19000789

Goe 6976 affects RELA

| 1 1

Goe 6976 inhibits RELA. 2 / 2

| 1 1

---

➶

reach

"ATPgammaS induced p38 MAPK, p42 and p44 MAPK, and NF-kappaB p65 activation were inhibited by Go6976, Ro-318220, GF109203X, or rottlerin."

23680674

---

➶

medscan

"Adenosine 5'-triphosphateγS-induced p38 MAPK, p42/p44 MAPK, and NF-κB p65 activation were inhibited by Gö6976, Ro-318220, GF109203X, or rottlerin."

23680674

Goe 6976 affects FOS

| 2

Goe 6976 inhibits FOS. 2 / 2

| 2

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➶

reach

"The cisplatin provoked c-fos induction was decreased by Go6976, a PKC-beta inhibitor; by siRNA for PKC-delta- but not that for PKC-epsilon or by PD98059, a mitogen activated protein kinase and ERK kinase inhibitor."

19254279

---

➶

reach

"The c-Fos induction was greatly diminished by Go6976 or PD098059, and completely abolished when combined."

15722198

Gly-Asn affects TRAF3

| 2

Gly-Asn inhibits TRAF3. 2 / 2

| 2

---

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reach

"The pathogenic NY-1 hantavirus Gn protein inhibits TRAF3 signaling by blocking the formation of TBK1-TRAF3 complexes XREF_BIBR whereas the LMP1 protein of Epstein-Barr virus directly binds to TRAF3 XREF_BIBR."

23717208

---

➶

reach

"For example, Gn protein of NY-1 hantavirus and M protein of severe acute respiratory syndrome (SARS) coronavirus disrupt or prevent the formation of TRAF3, TBK1, and IKKepsilon complex to inhibit type I IFN production [XREF_BIBR, XREF_BIBR]."

23758787

Glu-Ser affects RELA

| 2

Glu-Ser inhibits RELA. 2 / 2

| 2

---

➶

reach

"Furthermore, ES products suppressed nuclear factor (NF)-kappaB RelA (p65)-dependent transcriptional activity, whereas ES products had no effect on the kappaB binding activity."

22608126

---

➶

reach

"Furthermore, ES products suppressed nuclear factor (NF)-kappaB RelA (p65)-dependent transcriptional activity, whereas ES products had no effect on the kappaB binding activity."

22608126

GW743024X affects MAPK14

2 |

GW743024X inhibits MAPK14. 2 / 2

2 |

---

➶

tas

No evidence text available

18602262

---

➶

tas

No evidence text available

18614366

GW 501516 affects NFKB1

| 2

GW 501516 inhibits NFKB1. 2 / 2

| 2

---

➶

reach

"In control cells, GW501516 reduced both basal and TNFalpha stimulated Nfkb1 luciferase activity, as well as slightly elevating basal activity though not significant."

28955982

---

➶

reach

"GW501516 reduced Nfkb1 activity in control cells, but not when Pparb or Bcl6 were knocked down, indicating the potential repressive mechanism is dependent on both proteins."

28955982

GTP affects EIF2AK1

| 2

GTP inhibits EIF2AK1. 2 / 2

| 2

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➶

reach

"The GTP was added to prevent pressure activation of HCR during centrifugation [23]."

6924897

---

➶

reach

"GTP (2 mM) may prevent the activation of HRI in heme-deficiency and promote the reversion of active inhibitior to inactive form."

7159448

GSSG affects NFKB1

| 2

GSSG inhibits NFKB1. 2 / 2

| 2

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➶

reach

"A relatively high GSSG levels under conditions of selenium excess (Le Boeuf et al., 1985) reduces NFkB function (Combs and Gray 1998)."

30049188

---

➶

reach

"However, GSSG can have two antagonist effects towards NF-KB activation : very low levels of GSSG prevent cyto- plasmic activation of NF-KB, whereas very high doses of GSSG prevent the DNA binding capacity of NF-KB in the nucleus [44]."

9037247

EC 3.5.1.98 (histone deacetylase) inhibitor affects STAT1

| 2

EC 3.5.1.98 (histone deacetylase) inhibitor inhibits STAT1. 2 / 2

| 2

---

➶

reach

"HDACi exposure of primary blood cells fails to induce caspase activation and STAT1 reduction."

24810717

---

➶

reach

"HDACi prevent the removal of acetyl groups from lysine residues by histone deacetylases (HDACs), increase STAT1 acetylation and inhibit STAT1 signaling [25]."

22425562

EC 3.5.1.98 (histone deacetylase) inhibitor affects NLRP3

| 2

EC 3.5.1.98 (histone deacetylase) inhibitor inhibits NLRP3. 2 / 2

| 2

---

➶

reach

"These results showed that HDACi inhibited the activation of NLRP3 inflammasome in vitro."

26234821

---

➶

reach

"HDACi inhibited activation of NLRP3 inflammasome in 3T3-L1 cells."

26234821

EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor affects MAP3K7

| 1 1

EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor inhibits MAP3K7. 2 / 2

| 1 1

---

➶

reach

"ACEI inhibited SMAD2/3 and TAK1 pathways in vivo."

29463869

---

➶

sparser

"Therefore, the simultaneous inhibition of SMAD2/3 and TAK1 by ACEI is a promising strategy for blocking TGF-β1 signal transduction."

29463869

EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor affects STAT1

| 2

EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor inhibits STAT1. 2 / 2

| 2

---

➶

reach

"Finally, up-regulated IRF1 and P-STAT1 were also induced by the selective MEK inhibitor PD98059."

27322144

---

➶

reach

"To investigate this possibility, we determined the effect of FLUD (a specific STAT1 inhibitor), PD98059 (a specific MEK inhibitor), SB202190 (a specific p38 MAPK inhibitor), and LY294002 (a specific PI3K inhibitor) on gp120 induced STAT1 activation."

19103208

Doramapimod affects MAPK14

2 |

Doramapimod inhibits MAPK14. 2 / 2

2 |

---

➶

drugbank

No evidence text available

17139284

---

➶

drugbank

No evidence text available

17016423

Donepezil affects NFKB1

2 |

Donepezil inhibits NFKB1. 2 / 2

2 |

---

➶

drugbank

No evidence text available

25652642

---

➶

drugbank

No evidence text available

24189446

DOVITINIB affects TBK1

2 |

DOVITINIB inhibits TBK1. 2 / 2

2 |

---

➶

tas

No evidence text available

22037378

---

➶

tas

No evidence text available

DOVITINIB affects RIPK1

2 |

DOVITINIB inhibits RIPK1. 2 / 2

2 |

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

DOVITINIB affects JAK1

2 |

DOVITINIB inhibits JAK1. 2 / 2

2 |

---

➶

tas

No evidence text available

18183025

---

➶

tas

No evidence text available

22037378

DHM affects NLRP3

| 2

DHM inhibits NLRP3. 2 / 2

| 2

---

➶

reach

"In contrast, DHM attenuated ileum mucosal damage and oxidative stress, maintained the barrier function, and inhibited NLRP3 inflammasome and TLR4 and NF-kappaB signalling pathway activation."

32448367

---

➶

reach

"Therefore, this study explored the protective mechanisms of DHM against E. coli LPS induced ileum injury in chickens through antioxidants, alleviating intestinal lesions, inhibiting apoptosis and NLRP3 inflammasome, and analysed possible downstream targets of drug involving TLR4 and NF-kappaB signalling pathway."

32448367

DECERNOTINIB affects JAK1

2 |

DECERNOTINIB inhibits JAK1. 2 / 2

2 |

---

➶

tas

No evidence text available

24417533

---

➶

tas

No evidence text available

26351728

DDE affects RELA

| 2

DDE inhibits RELA. 2 / 2

| 2

---

➶

reach

"As illustrated in XREF_FIG, our analysis suggests that fetuin A can be activated by TCDD via the AhR and RelA (activation of an activator), and then RelA directly activates fetuin A. PCB 153 and p, p '-DDE can inhibit RelA (inhibition of an inhibitor) via the PXR and the AR, respectively, and then RelA can activate fetuin A. Again, it is a noteworthy observation that RelA could represent a common step in the activation of fetuin A, IL-6, and TNF-alpha by all of these POPs."

26685285

---

➶

reach

"PCB 153 and p, p '-DDE can inhibit RelA (inhibition of an inhibitor) via PXR and AR, respectively, and then RelA activates IL-6."

26685285

D-threo-isocitric acid affects FOS

| 2

D-threo-isocitric acid inhibits FOS. 2 / 2

| 2

---

➶

reach

"For example, ICI antagonized the estrogen induction of PR, c-fos, lactoferrin and vascular endothelial growth factor genes in mouse uterus [26,27]."

11457666

---

➶

reach

"Further experiments demonstrate that the estrogen receptor inhibitor ICI 182780 and siRNA mediated c-fos or MMP-9 knockdown are able to block the effect of 17beta-E2 on HESC invasion."

26917263

CCCP affects STING1

| 2

CCCP inhibits STING1. 2 / 2

| 2

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➶

reach

"Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING mediated DNA sensing pathway through inducing mitochondrial fission."

28859978

---

➶

reach

"Here, we show that CCCP inhibits activation of STING and its downstream signaling molecules, TBK1 and IRF3, but not STING translocation to the perinuclear region."

28859978

C646 affects RELA

| 2

C646 inhibits RELA. 2 / 2

| 2

---

➶

reach

"Importantly, the induced p65 promoter occupancy at 48 h was also inhibited by C646, indicating that the CBP HAT activity is required for p65 recruitment."

29050320

---

➶

reach

"C646 exposure also decreased NF-kappaB and p65 protein, which was not due to reduced mRNA and was not attenuated with catalase pre-treatment."

27381264

Beta-D-Glucose affects IFNB1

2 |

Beta-D-Glucose inhibits IFNB1. 2 / 2

2 |

---

➶

drugbank

No evidence text available

17139284

---

➶

drugbank

No evidence text available

17016423

Baricitinib affects JAK1

2 |

Baricitinib inhibits JAK1. 2 / 2

2 |

---

➶

drugbank

No evidence text available

27028914

---

➶

drugbank

No evidence text available

28255337

BLOC1S4 affects FOS

| 2

BLOC1S4 inhibits FOS. 2 / 2

| 2

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"Strikingly, CNO significantly increased c-Fos immunoreactivity in the VTA dopamine neurons and decreased c-Fos immunoreactivity of non dopamine cells."

28420875

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"We observed that activation of striatal hM 4 Di with CNO (2mg/kg, i.p.) before a cocaine challenge (15mg/kg, i.p.) significantly inhibited c-Fos activation in animals expressing hM 4 Di versus GFP controls (control were also administered CNO before cocaine challenge) [Figures XREF_FIG C, D; t (13) = 2.78, p < 0.02], suggesting that activation of hM 4 Di via CNO before cocaine challenge inhibited cAMP pathway activity by G i/o -coupled inhibition."

29686629

Auranofin affects IKBKB

2 |

Auranofin inhibits IKBKB. 2 / 2

2 |

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drugbank

No evidence text available

17034761

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➶

drugbank

No evidence text available

12754408

Asp-Val affects DDX58

| 2

Asp-Val inhibits DDX58. 2 / 2

| 2

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"These results indicate that DV NS3 inhibits RIG-I- and 14-3-3epsilon-mediated signaling in a cleavage independent manner."

26998762

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➶

reach

"For example, DV NS3, NS4A, and NS5 inhibit the RIG-I pathway activation by the methylation of the DV RNA (DV NS5) or by blocking the RIG-I and MAVS interaction (DV NS4A)."

32411105

Asp-Glu affects FOS

| 2

Asp-Glu inhibits FOS. 2 / 2

| 2

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"De Groot, R.P., Rijken, P.J., Den Hertog, J., Boonstra, J., Verkleij, A.J., De Laat, S.W. and Kruijer, W. (1990) Microgravity decreases c-fos induction and serum response element activity."

9026045

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"De Groot R.P., Rijken, P., Den Hertog, J., and Boonstra, J. Microgravity decreases c-fos induction and serum response element activity."

9028534

Arg-Val affects STAT2

| 2

Arg-Val inhibits STAT2. 2 / 2

| 2

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"Furthermore, RV infection was observed to block the migration of STAT1, STAT2 and NF-kappaB to the nucleus, thus preventing host cell immune responses [XREF_BIBR]."

29231855

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reach

"RV has also been shown to inhibit the function of STAT1 and STAT2 by an unknown mechanism and thus, can potentially inhibit all types of IFN responses [XREF_BIBR]."

22677178

Arg-Val affects IRF3

| 2

Arg-Val inhibits IRF3. 2 / 2

| 2

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reach

"We found that MDA5 and TRIF siRNA each caused a partial reduction in RV induced IRF3 dimerization compared to non targeting siRNA transfected cells, confirming in airway epithelial cells the general notion that IRF3 functions downstream of MDA5 and TRIF."

19890046

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reach

"This was consistent with previous observations that degradation of IRF3 by RV varies among different strains and cell lines XREF_BIBR."

23437200

Arg-Val affects DDX58

| 2

Arg-Val inhibits DDX58. 2 / 2

| 2

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"Uninfected STRA BECs exhibited lower TLR3 mRNA levels and impaired RV induced RIG-I and MDA5 mRNA abundance at 24h."

23212197

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reach

"This induction is controlled by the protein N of RV pathogenic strains, which prevents RIG-I activation and further CCL5 production, leading to disease and lethality in infected mice [77]."

24090198

Adapalene affects JUN

2 |

Adapalene inhibits JUN. 2 / 2

2 |

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drugbank

No evidence text available

15727806

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➶

drugbank

No evidence text available

26947815

ATP affects STAT1

| 2

ATP inhibits STAT1. 2 / 2

| 2

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"As expected, in wild-type mice, the levels of insulin content and ATP production were decreased significantly by STZ administration, but not in STAT1 -/- mice (XREF_FIG)."

19647793

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➶

reach

"Other phospholipase C (PLC)-coupled GPCR agonists, bradykinin and ATP, also inhibited Stat1 activation."

9398658

ATP affects PYCARD

| 2

ATP inhibits PYCARD. 2 / 2

| 2

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"Furthermore, we found that ATP induced ASC oligomerization was significantly reduced by GlcN."

30944389

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reach

"The PKA inhibitor H89 increased the ASC speck formation induced by ATP, and it could partly reversed the inhibitory effect of baicalin on ATP induced ASC speck formation, further confirming that PKA signaling had been involved in the action of baicalin on suppressing NLRP3 inflammasome activation."

29163487

ATP affects JUN

| 1 1

ATP inhibits JUN. 2 / 2

| 1 1

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"Using cell-free degradation assays, we show that ubiquitinylation, along with other types of tagging, is not an absolute prerequisite for ATP dependent degradation of c-Jun by the 26 S proteasome."

7744802

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medscan

"We found that removal of extracellular adenosine 5'-triphosphate or inhibition of P2X7 receptors prevented shockwave-induced p38 MAPK activation, osteogenic differentiation and transcription of cfos, c-jun."

23404811

ATP affects EIF2AK1

| 2

ATP inhibits EIF2AK1. 2 / 2

| 2

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"d HRI binds ATP; however, if the HRI has previously been treated with heroin, the ATP binding Is significantly reduced "."

7709427

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reach

"This interpretation is consistent with an earlier finding that the presence 764 of ATP prevents the inactivation of lysate HRI by high concentrations of NEM [36], an observation suggesting that free sulfhydryl groups are near the active site of HRI."

7893826

AST-487 affects RIPK1

2 |

AST-487 inhibits RIPK1. 2 / 2

2 |

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No evidence text available

22037378

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No evidence text available

18183025

APP affects NLRP3

| 2

APP inhibits NLRP3. 2 / 2

| 2

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reach

"Cho et al [XREF_BIBR] showed that autophagy contributes to the clearance of extracellular beta-amyloid (Abeta) fibrils and suppression of Abeta induced NLRP3 inflammasome."

27611972

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reach

"Puerarin inhibits amyloid beta induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS dependent oxidative and endoplasmic reticulum stresses."

28583762

AKTIP affects IRF7

| 2

AKTIP inhibits IRF7. 2 / 2

| 2

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"7 Using a gene array method, we demonstrate that FTS, by targeting Rheb, can inhibit the function of IRF7 in AML cells, thereby mimicking the effects of rapamycin and re-expression of TSC2."

25476905

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reach

"FTS, rapamycin and re-expression of TSC2 inhibit the IRF7 transcription factor."

25476905

AICA ribonucleotide affects CASP1

| 2

AICA ribonucleotide inhibits CASP1. 2 / 2

| 2

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reach

"Moreover, AICAR could also abolish alpha-Syn-induced activation of caspase-1 (Additional file 3 : Figure S3f) and the increase of IL-1beta production (Additional file 3 : Figure S3g)."

27084336

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➶

reach

"AICAR and salicylate inhibited NLRP3 induction and caspase-1 activation, and as a result, IL-1beta secretion was reduced."

26196303

ADP affects CHUK

| 2

ADP inhibits CHUK. 2 / 2

| 2

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"Therefore the inhibition of autophosphorylation due to occupying active sites with ADP would have to be somewhat offset by an increased affinity of ADP bound IKK in an autophosphorylation reaction.To test whether the autophosphorylation is intermolecular, the inhibition of IKK-1 by ADP at two enzyme concentrations was measured."

12054687

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"The results are represented as pseudo-Dixon plots (i.e., ratio of the rate of product formed in the absence to that in the presence of inhibitor versus concentration of inhibitor) to more easily gauge the relative inhibition of each phosphorylation product.The use of ADP, which has been shown to inhibit IKK-1 and IKK-2 competitively with respect to ATP [16], showed an even more pronounced effect, with the enzyme catalyzed IkappaBalpha phosphorylation inhibited considerably more potently than autophosphorylation with both IKK-1 and IKK-2."

12054687

ABT-737 affects CASP1

| 2

ABT-737 inhibits CASP1. 2 / 2

| 2

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reach

"In addition, ABT-737 reduced the degree of caspase-1 activity compared to that in AR mice."

29856968

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➶

reach

"ABT-737 significantly decreased thymic stromal lymphopoietin (TSLP) secretion and caspase-1 activity in activated HaCaT cells."

29957081

ABROCITINIB affects TYK2

2 |

ABROCITINIB inhibits TYK2. 2 / 2

2 |

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No evidence text available

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No evidence text available

29298069

ABROCITINIB affects JAK1

2 |

ABROCITINIB inhibits JAK1. 2 / 2

2 |

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No evidence text available

---

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tas

No evidence text available

29298069

7-(3,5-dimethyl-4-isoxazolyl)-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-3H-imidazo[4,5-c]quinolin-2-one affects STAT1

| 1 1

7-(3,5-dimethyl-4-isoxazolyl)-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-3H-imidazo[4,5-c]quinolin-2-one inhibits STAT1. 2 / 2

| 1 1

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reach

"Consistent with the observation that I-BET151 did not significantly inhibit IFN-beta-induced IRF1 or STAT1 (XREF_FIG), Pol II recruitment to the regulatory regions of these two genes were not significantly affected by I-BET151 (XREF_FIG)."

25345375

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sparser

"Consistent with the observation that I-BET151 did not significantly inhibit IFN-β-induced IRF1 or STAT1 ( xref ), Pol II recruitment to the regulatory regions of these two genes were not significantly affected by I-BET151 ( xref )."

25345375

7-(3,5-dimethyl-4-isoxazolyl)-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-3H-imidazo[4,5-c]quinolin-2-one affects IFNB1

| 2

7-(3,5-dimethyl-4-isoxazolyl)-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-3H-imidazo[4,5-c]quinolin-2-one inhibits IFNB1. 2 / 2

| 2

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reach

"We next addressed whether, in addition to inhibiting IFN-beta production, I-BET151 could also inhibit IFN-beta function by suppressing cellular responses to IFN-beta."

25345375

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➶

reach

"Similar to the TLR3-TBK1-IRF3 pathway, we found that BI-2536, JQ1 and I-BET151 blocked the TLR7- or TLR9 stimulated secretion of IFNbeta in Gen2.2 cells (XREF_FIG A and XREF_FIG B), without affecting the TLR stimulated translocation of the endogenous IRF5 to the nucleus (XREF_FIG C)."

25891802

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one affects TYK2

2 |

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one inhibits TYK2. 2 / 2

2 |

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No evidence text available

---

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tas

No evidence text available

22037378

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one affects TBK1

2 |

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one inhibits TBK1. 2 / 2

2 |

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No evidence text available

---

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No evidence text available

22037378

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one affects IKBKE

2 |

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one inhibits IKBKE. 2 / 2

2 |

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tas

No evidence text available

22037378

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tas

No evidence text available

6-[5-[(cyclopropylamino)-oxomethyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide affects MAPK14

2 |

6-[5-[(cyclopropylamino)-oxomethyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide inhibits MAPK14. 2 / 2

2 |

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No evidence text available

19950901

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tas

No evidence text available

19772287

6-(4-fluorophenyl)-5-pyridin-4-yl-2,3-dihydroimidazo[2,1-b]thiazole affects MAPK14

2 |

6-(4-fluorophenyl)-5-pyridin-4-yl-2,3-dihydroimidazo[2,1-b]thiazole inhibits MAPK14. 2 / 2

2 |

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tas

No evidence text available

14561090

---

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tas

No evidence text available

8831759

6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)Pyrazine affects MAPK14

2 |

6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)Pyrazine inhibits MAPK14. 2 / 2

2 |

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drugbank

No evidence text available

17016423

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➶

drugbank

No evidence text available

17139284

5-methylphenazinium methyl sulfate affects CASP1

| 2

5-methylphenazinium methyl sulfate inhibits CASP1. 2 / 2

| 2

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reach

"And N. caninum infection in Nlrp3 -/- PMs displayed greatly decreased IL-1beta release and inhibited caspase-1 cleavage, this result revealed and confirmed that inflammasome mediated secretion of IL-1beta and cleavage of caspase-1 caused by N. caninum infection was highly dependent on NLRP3 inflammasome."

28558839

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➶

reach

"In addition, N. caninum infection in Nlrp3 -/- PMs displayed extremely decreased release of IL-1beta and inhibited cleavage of caspase-1."

28558839

5-methylcytidine affects TLR7

| 1 1

5-methylcytidine inhibits TLR7. 2 / 2

| 1 1

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➶

eidos

"of pseudouridine ( Psi ) , 5methylcytidine ( m5C ) , 2thio uridine ( s2U ) or N6methyladenosine ( m6A ) was found to potently inhibit TLR7 and TLR8 and to reduce TLR3 activity , which is the least sensitive receptor to RNA modifications 88 ."

27455396

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➶

reach

"Incorporation of pseudouridine (Ψ), 5-methylcytidine (m5C), 2-thio-uridine (s2U) or N6-methyladenosine (m6A) was found to potently inhibit TLR7 and TLR8 and to reduce TLR3 activity, which is the least sensitive receptor to RNA modifications88."

27455396

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects FOS

| 2

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole inhibits FOS. 2 / 2

| 2

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reach

"In contrast, omeprazole reduced binding of acidic bile salt stimulated c-jun and c-fos to the IL-8 promoter to control levels (XREF_FIG)."

24048734

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➶

reach

"The c-Fos response to HCl was diminished by cimetidine and omeprazole, enhanced by pentagastrin, and left unchanged by dexloxiglumide and itriglumide."

14592947

5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine affects TYK2

2 |

5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine inhibits TYK2. 2 / 2

2 |

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tas

No evidence text available

---

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tas

No evidence text available

22037378

5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine affects TBK1

2 |

5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine inhibits TBK1. 2 / 2

2 |

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No evidence text available

22037378

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tas

No evidence text available

5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine affects MAPK8

2 |

5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine inhibits MAPK8. 2 / 2

2 |

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No evidence text available

---

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tas

No evidence text available

22037378

4-methylumbelliferone affects NFKB1

| 2

4-methylumbelliferone inhibits NFKB1. 2 / 2

| 2

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reach

"At IC 50, 4-MU also caused> 90% inhibition of NFkB reporter activity which was prevented partially by HA addition."

20332231

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➶

reach

"At 0.4 mM, 4-MU inhibited NFkB reporter activity by 83% (51.8 +/- 6.8 versus 8.8 +/- 2.3; P < 0.001 unpaired t-test), and HA partially prevented this inhibition (relative activity : 29.6 +/- 2.0)."

20332231

4-hydroxyphenyl retinamide affects JUN

| 2

4-hydroxyphenyl retinamide inhibits JUN. 2 / 2

| 2

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➶

reach

"However, like natural retinoids, 4-HPR and compound 3 actively suppressed c-Jun transcriptional activity."

14519946

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➶

reach

"4-HPR also repressed c-Jun activity with higher strength than others."

11689287

4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone affects TBK1

2 |

4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone inhibits TBK1. 2 / 2

2 |

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No evidence text available

22037378

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tas

No evidence text available

4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone affects RIPK1

2 |

4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone inhibits RIPK1. 2 / 2

2 |

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tas

No evidence text available

18183025

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No evidence text available

22037378

4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone affects JAK1

2 |

4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone inhibits JAK1. 2 / 2

2 |

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No evidence text available

18183025

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tas

No evidence text available

22037378

4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide affects TYK2

2 |

4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide inhibits TYK2. 2 / 2

2 |

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tas

No evidence text available

18183025

---

➶

tas

No evidence text available

21106455

4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide affects MAPK8

2 |

4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide inhibits MAPK8. 2 / 2

2 |

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tas

No evidence text available

18183025

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➶

tas

No evidence text available

4-[5-[2-(1-Phenyl-Ethylamino)-Pyrimidin-4-Yl]-1-Methyl-4-(3-Trifluoromethylphenyl)-1h-Imidazol-2-Yl]-Piperidine affects MAPK14

2 |

4-[5-[2-(1-Phenyl-Ethylamino)-Pyrimidin-4-Yl]-1-Methyl-4-(3-Trifluoromethylphenyl)-1h-Imidazol-2-Yl]-Piperidine inhibits MAPK14. 2 / 2

2 |

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➶

drugbank

No evidence text available

17139284

---

➶

drugbank

No evidence text available

17016423

4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1-imidazolyl]-1-cyclohexanol affects MAPK8

2 |

4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1-imidazolyl]-1-cyclohexanol inhibits MAPK8. 2 / 2

2 |

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No evidence text available

11597418

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tas

No evidence text available

4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1-imidazolyl]-1-cyclohexanol affects MAPK14

2 |

4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1-imidazolyl]-1-cyclohexanol inhibits MAPK14. 2 / 2

2 |

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tas

No evidence text available

18077363

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➶

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No evidence text available

11597418

4-[3-fluoro-5-(4-morpholinyl)phenyl]-N-[4-[3-(4-morpholinyl)-1,2,4-triazol-1-yl]phenyl]-2-pyrimidinamine affects MAPK8

2 |

4-[3-fluoro-5-(4-morpholinyl)phenyl]-N-[4-[3-(4-morpholinyl)-1,2,4-triazol-1-yl]phenyl]-2-pyrimidinamine inhibits MAPK8. 2 / 2

2 |

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No evidence text available

25415535

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No evidence text available

19947601

4-(ethoxymethylene)-2-phenyloxazol-5-one affects STAT1

| 2

4-(ethoxymethylene)-2-phenyloxazol-5-one inhibits STAT1. 2 / 2

| 2

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➶

reach

"p47 phox deficiency in T cells diminished the expression of transcription factors STAT1, STAT4, and T-bet and reduced the production of cytokine, such as IL-2, IL-4, IFN-gamma, TNF-alpha, and GM-CSF [XREF_BIBR]."

27547291

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➶

reach

"The oxazolone induced pSTAT1 response was inhibited by orally dosed tofacitinib (1-30mg/kg) by up to 88 +/-5% (mean +/- SEM) when dosed 3h after intrarectal oxazolone."

29225517

3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine affects IKBKE

2 |

3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine inhibits IKBKE. 2 / 2

2 |

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tas

No evidence text available

22037378

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tas

No evidence text available

3-(trimethylsilyl)propane-1-sulfonic acid affects CASP1

| 2

3-(trimethylsilyl)propane-1-sulfonic acid inhibits CASP1. 2 / 2

| 2

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➶

reach

"Further study revealed that WEL treatment dramatically inhibited NLRP3 inflammasome activation and caspase-1 phosphorylation to decrease IL-1beta release in colons treated with DSS."

28750357

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➶

reach

"DCA Administration Exacerbates DSS Induced Colitis and Caspase-1 Inhibition Exhibits Significant Protective Role."

27965665

3-(dimethylamino)-N-[3-[[(4-hydroxyphenyl)-oxomethyl]amino]-4-methylphenyl]benzamide affects MAPK14

2 |

3-(dimethylamino)-N-[3-[[(4-hydroxyphenyl)-oxomethyl]amino]-4-methylphenyl]benzamide inhibits MAPK14. 2 / 2

2 |

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tas

No evidence text available

18077363

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➶

tas

No evidence text available

15454231

24,25-Dihydroxyvitamin D affects STAT1

| 2

24,25-Dihydroxyvitamin D inhibits STAT1. 2 / 2

| 2

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reach

"Importantly, we showed that vitamin D treatment, as well as other compounds previously shown to ameliorate disease phenotype like farnesyltransferase inhibitors and rapamycin [XREF_BIBR], all-trans retinoic acid [XREF_BIBR, XREF_BIBR, XREF_BIBR], and remodelin [XREF_BIBR], markedly repress the STAT1 and IFN like response [XREF_BIBR]."

29637811

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➶

reach

"Furthermore, vitamin D decreases STAT1 activation and pro inflammatory cytokine output in the mouse model of EAE, correlating with a lesser disease state and improved symptomology."

27743385

2-tert-butylhydroquinone affects RELA

| 2

2-tert-butylhydroquinone inhibits RELA. 2 / 2

| 2

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reach

"At the same time, tBHQ activated Nrf2 mediated inhibition of the p65 nuclear factor-kappaB pathway and activation of peroxisome proliferator activated receptor-gamma, which play important roles in regulating macrophage polarization."

29684352

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➶

reach

"However, these studies demonstrated that tBHQ inhibited NFkappaB p65 transcriptional activity in activated Jurkat T cells [XREF_BIBR]."

25484350

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one affects RELA

| 2

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one inhibits RELA. 2 / 2

| 2

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➶

reach

"In hHM, P6 inhibits RelA-P-Ser536, but not RelA, nuclear translocation, which provides an explanation as to why P6 only affects a subset, and not all, of NF-kappaB-regulated inflammatory genes."

22996371

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➶

reach

"We can not rule out the possibility that P6 disrupts RelA complexes with IKK, other kinases or coactivators, or changes dimer composition to exert its effects."

22996371

2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione affects RELA

| 2

2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione inhibits RELA. 2 / 2

| 2

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➶

reach

"TQ specifically suppressed the direct binding of nuclear p65 and recombinant p65 to the DNA, and this binding was reversed by DTT."

20924969

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➶

reach

"TQ specifically suppressed the direct binding of nuclear p65 and recombinant p65 to the DNA, and this binding was reversed by DTT."

18567808

2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione affects NLRP3

| 1 1

2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione inhibits NLRP3. 2 / 2

| 1 1

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➶

reach

"These results indicate that TQ downregulated caspase-1 and NLRP3 in the CLP group mice."

32626733

---

➶

eidos

"These results indicate that TQ downregulated caspase-1 and NLRP3 in the CLP group mice ."

32626733

2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione affects NFKB1

| 2

2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione inhibits NFKB1. 2 / 2

| 2

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➶

reach

"Although further demonstrations are necessary, inactivation of KIT and FLT3 signaling by TQ may occur via their gene downregulation resulting from TQ disrupted Sp1 and NFkB functions."

28415607

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➶

reach

"However, how TQ manifests these activities is not fully understood, although it has been shown to downregulate the expression of Bcl-xL [XREF_BIBR], COX-2 [XREF_BIBR], iNOS [XREF_BIBR], 5-LOX [XREF_BIBR], TNF [XREF_BIBR] and cyclin D1 [XREF_BIBR], all known to be regulated by NFkB activity that can be blocked by TQ [XREF_BIBR]."

28415607

2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione affects IRF3

| 2

2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione inhibits IRF3. 2 / 2

| 2

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reach

"This indicates that TQ acts to downregulate IRF-3 partly by inhibition of TBK1 autophosphorylation."

29751576

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➶

reach

"Taken together, these findings suggest that TQ can downregulate IRF-3 activation via inhibition of TBK1, which would subsequently decrease the production of type I IFN."

29751576

2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione affects CASP1

| 1 1

2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione inhibits CASP1. 2 / 2

| 1 1

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➶

reach

"These results indicate that TQ downregulated caspase-1 and NLRP3 in the CLP group mice."

32626733

---

➶

eidos

"These results indicate that TQ downregulated caspase-1 and NLRP3 in the CLP group mice ."

32626733

2-acetyl-1-pyrroline affects FOS

| 2

2-acetyl-1-pyrroline inhibits FOS. 2 / 2

| 2

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reach

"However, 2AP does block the induction of the c-fos and c-myc proto-oncogenes by serum growth factors or virus, suggesting that a protein kinase may be involved in the regulation of these genes, as well as of the beta-interferon gene."

3281258

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➶

reach

"2AP inhibited the TNF-alpha-induced expression of NFATc1 and c-fos, master transcription factors in osteoclastogenesis."

25739386

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one affects RELA

| 2

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one inhibits RELA. 2 / 2

| 2

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➶

reach

"Donepezil (5mg/kg) treatment also decreased the relative density of p-p65 and p65 when compared with AlCl 3 + vehicle group (p < 0.01)."

29946349

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➶

reach

"Donepezil (5mg/kg) treatment also decreased the relative density of p-p65 and p65 when compared with the AlCl 3 + vehicle group (p < 0.01)."

29946349

2-Chlorophenol affects MAPK14

2 |

2-Chlorophenol inhibits MAPK14. 2 / 2

2 |

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➶

drugbank

No evidence text available

17139284

---

➶

drugbank

No evidence text available

17016423

2-(\{2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl\}amino)benzamide affects MAPK8

2 |

2-(\{2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl\}amino)benzamide inhibits MAPK8. 2 / 2

2 |

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➶

tas

No evidence text available

17107797

---

➶

tas

No evidence text available

26704265

2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranone affects IKBKG

| 2

2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranone inhibits IKBKG. 2 / 2

| 2

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reach

"Ku55933 significantly inhibited (p = < 0.05) radiation mediated induction of pNEMO in U937 cells, lacking p53, at 1, 4, 8, and 16 hrs after 2 Gy and 20 Gy, with less inhibition at 24 hrs (XREF_FIG)."

23649044

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reach

"Ku55933 also significantly inhibited (p = < 0.05) doxorubicin mediated induction of pNEMO in U937 mutant cells at 1, 4, 8, and 16 and 24 hrs after doxorubicin (0.25 mug/ml) treatment (XREF_FIG)."

23649044

2-(2-amino-3-methoxyphenyl)chromen-4-one affects CHUK

| 2

2-(2-amino-3-methoxyphenyl)chromen-4-one inhibits CHUK. 2 / 2

| 2

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➶

medscan

"The OPN-mediated increases in IKK alpha/beta, IkappaBalpha and p65 Ser(536) phosphorylation were inhibited by Ly294002, Akt inhibitor and PD98059. 32999999="S536"}"

18996613

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➶

medscan

"The peptidoglycan-mediated increase in the activities of IKKalpha/beta and kappaB-luciferase were also inhibited by the Ras dominant negative mutant (RasN17), manumycin A, GW 5074, and PD 098059."

15007072

2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione affects RELA

2 |

2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione inhibits RELA. 2 / 2

2 |

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➶

ctd

No evidence text available

17164350

---

➶

ctd

No evidence text available

14713331

17beta-estradiol affects RELA

| 2

17beta-estradiol inhibits RELA. 2 / 2

| 2

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reach

"Furthermore, because of the association of p65 with the estrogen receptor, 17beta-estradiol blocked the binding of p65 to the gene target inducible NOS (iNOS)."

25366597

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➶

reach

"17beta-estradiol, via ERalpha, can also inhibit the transport of p65 to the nucleus and downregulate inflammation [XREF_BIBR]."

29085224

15(S)-HETE affects NFKBIA

| 2

15(S)-HETE inhibits NFKBIA. 2 / 2

| 2

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reach

"We have also recently shown that both PIF (Whitehouse and Tisdale, 2003) and 15 (S)-hydroxyeicosatetraenoic acid (15 (S)-HETE), an intracellular signal for the increased protein degradation induced by PIF (Whitehouse et al, 2003), cause degradation of IkappaBalpha and nuclear accumulation of NF-kappaB, associated with an increased proteasome expression."

15714207

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➶

reach

"15 (S)-hydroxyeicosatetraenoic acid activated binding of nuclear factor-kappaB (NF-kappaB) in the myotube nucleus and stimulated degradation of I-kappaBalpha."

12915888

1-phenylpropan-2-amine affects FOS

| 2

1-phenylpropan-2-amine inhibits FOS. 2 / 2

| 2

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reach

"The role of D 2 receptors in the activation of c-fos by amphetamine has been investigated using the D 2 antagonists haloperidol and YO9151, but the interpretation of the observed reduction in amphetamine induced c-fos is rendered difficult by the fact that haloperidol and YO9151 could also induce c-fos expression on their own (Graybiel et al., 1990; Nguyen et al., 1992)."

10471092

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reach

"In line with these findings, the induction of several immediate early gene mRNAs (c-fos, fosB, c-jun, junB, and zif268) was reduced following repeated cocaine injections in comparison to acute drug injections, and amphetamine induced c-fos was suppressed following withdrawal from chronic amphetamine administration."

20618447

1-fluoro-2,4-dinitrobenzene affects ITCH

| 2

1-fluoro-2,4-dinitrobenzene inhibits ITCH. 2 / 2

| 2

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reach

"In DNFB treated mice, neither of these suppression effects by chlorpheniramine was observed, indicating that the H1 receptor is not involved in DNFB induced itch and spinal ERK activation, which is consistent with the clinical data [XREF_BIBR]."

24708812

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➶

reach

"Blocking phosphorylation of ERK suppresses histamine- and DNFB induced itch responses."

24708812

1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One affects MAPK14

2 |

1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One inhibits MAPK14. 2 / 2

2 |

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➶

drugbank

No evidence text available

17139284

---

➶

drugbank

No evidence text available

17016423

1,8-cineole affects RELA

| 2

1,8-cineole inhibits RELA. 2 / 2

| 2

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reach

"Additionally, eucalyptol decreased the NF-kappa B p65 subunit at 3mg/mL and 10mg/mL compared to the CS group (p < 0.01)."

27599597

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➶

reach

"Greiner et al. have demonstrated that 1,8-cineol inhibits the nuclear import of the transcriptional activator protein NF-kappaB p65 and correspondingly its transcriptional activity leading to decreased cell proliferation."

28589081

1,8-cineole affects NLRP3

| 2

1,8-cineole inhibits NLRP3. 2 / 2

| 2

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reach

"We also observed that 1,8-cineole, the major component of L. nobilis extract, consistently suppressed NLRP3 inflammasome activation."

30387132

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➶

reach

"Eucalyptol inhibited NLRP3 inflammasome activation and pro inflammatory cytokine productions induced by MSU in ankle tissues in vivo."

31883118

1,4-dithiothreitol affects MAVS

| 2

1,4-dithiothreitol inhibits MAVS. 2 / 2

| 2

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reach

"However, DTT treatment of cells blocked MAVS aggregation as well as IRF3 activation by Sendai virus (XREF_SUPPLEMENTARY)."

21782231

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➶

reach

"Thus, DTT treatment prevented the detection of MAVS aggregates using the SDD-AGE assay, but did not cause the breakdown of the MAVS aggregates, which could be isolated by ultracentrifugation."

21782231

1,4-dithiothreitol affects IKBKB

1 | 1

1,4-dithiothreitol inhibits IKBKB. 2 / 2

1 | 1

---

➶

ctd

No evidence text available

17067557

---

➶

reach

"Mechanistically, H2S was proved to inhibit IKKbeta activity directly via sulfhydrating IKKbeta at cysteinyl residue 179 (C179) in purified recombinant IKKbeta protein in vitro, whereas thiol reductant dithiothreitol (DTT) reversed H2S induced IKKbeta inactivation."

31654061

1,4-dithiothreitol affects CASP1

| 1 1

1,4-dithiothreitol inhibits CASP1. 2 / 2

| 1 1

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➶

reach

"Caspase-1, shown to be involved in both apoptosis and cytokine maturation, is also thought to be S -nitrosylated with the demonstration of the reversal of NO induced inhibition of caspase-1 by DTT in macrophages (Kim et al., 1998b)."

12072178

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sparser

"Caspase-1, shown to be involved in both apoptosis and cytokine maturation, is also thought to be S -nitrosylated with the demonstration of the reversal of NO-induced inhibition of caspase-1 by DTT in macrophages (Kim et al., 1998b) ."

12072178

1,1-bis(phosphonic acid) affects FOS

| 2

1,1-bis(phosphonic acid) inhibits FOS. 2 / 2

| 2

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➶

sparser

"At the mRNA level, BP inhibits the OC-associated transcription factor NFATc1 and c-fos, thereby affecting the expression of OC differentiation-related genes."

30579598

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➶

sparser

"At the mRNA level, BP inhibits the OC-associated transcription factor NFATc1 and c-fos, thereby affecting the expression of OC differentiation-related genes."

30579598

(S)-amphetamine affects FOS

| 2

(S)-amphetamine inhibits FOS. 2 / 2

| 2

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reach

"These results suggest 2 mg/kg d-amphetamine reduced c-Fos, and that levels were recovered to baseline because of the increased locomotor stimulation."

23178911

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➶

reach

"Low doses of d-amphetamine decreased c-Fos and DeltaFosB in the granule layer."

23178911

(R)-rosmarinic acid affects JUN

| 1 1

(R)-rosmarinic acid inhibits JUN. 2 / 2

| 1 1

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reach

"Rosmarinic acid reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 promoter activity and protein levels in colon cancer HT-29 cells, repressed binding of the activator protein-1 (AP-1) in a nonmalignant breast epithelial cell line (MCF10A), and antagonized the stimulatory effects of TPA on COX-2 protein expression [XREF_BIBR]."

22583408

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sparser

"RANKL-induced p38 mitogen-activated protein kinase and the expression of nuclear factor of activated T cell, c-Jun, and c-Fos were inhibited by rosmarinic acid in bone marrow macrophages."

25380345

(R)-rosmarinic acid affects FOS

| 1 1

(R)-rosmarinic acid inhibits FOS. 2 / 2

| 1 1

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sparser

"RANKL-induced p38 mitogen-activated protein kinase and the expression of nuclear factor of activated T cell, c-Jun, and c-Fos were inhibited by rosmarinic acid in bone marrow macrophages."

25380345

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➶

reach

"RANKL induced p38 mitogen activated protein kinase and the expression of nuclear factor of activated T cell, c-Jun, and c-Fos were inhibited by rosmarinic acid in bone marrow macrophages."

25380345

(R)-lipoic acid affects NLRP3

| 2

(R)-lipoic acid inhibits NLRP3. 2 / 2

| 2

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reach

"These results indicated that LA might reduce the promotion of the NLRP3 inflammasome to inhibit inflammation."

30158835

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➶

reach

"These results strongly suggest that LA could inhibit inflammation by downregulating NF- kappa B/MAPK pathways and NLRP3 inflammasome activation in activated macrophages."

30452073

(R)-lipoic acid affects NFKBIA

| 2

(R)-lipoic acid inhibits NFKBIA. 2 / 2

| 2

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reach

"To test whether LA inhibits NF-kappaB activation through its antioxidant function, we compared the effect of LA on TNFalpha induced IkappaBalpha degradation to other well-known antioxidants."

20927568

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➶

reach

"LA also inhibited the activation of nuclear factor-kappaB and degradation of IkappaBalpha."

30011850

(R)-lipoic acid affects JUN

| 2

(R)-lipoic acid inhibits JUN. 2 / 2

| 2

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➶

reach

"This work investigated the capacity of alpha-lipoic acid (LA) and N-acetyl-L-cysteine (NAC) to reduce zinc deficiency induced oxidative stress, and prevent the activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), and the cross-talk between both activated cascades through beta-Transducin Repeat containing Protein (beta-TrCP)."

16298762

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➶

reach

"This work investigated the capacity of alpha-lipoic acid (LA) and N-acetyl-L-cysteine (NAC) to reduce zinc deficiency induced oxidative stress, and prevent the activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), and the cross-talk between both activated cascades through beta-Transducin Repeat containing Protein (beta-TrCP)."

16298762

(R)-lipoic acid affects CASP1

| 2

(R)-lipoic acid inhibits CASP1. 2 / 2

| 2

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➶

reach

"Additionally, LA inhibited the production of IL-1 beta and IL-18, as well as caspase-1 maturation, by inhibition of NLRP3 inflammasome activation in LPS and ATP stimulated cells."

30452073

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➶

reach

"Pretreatment of LA and AH significantly reduced caspase-1 activation without displaying host cell cytotoxicity in activated human mast cells."

31368553

(E)-cinnamaldehyde affects NLRP3

| 2

(E)-cinnamaldehyde inhibits NLRP3. 2 / 2

| 2

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➶

reach

"Cinnamaldehyde suppresses NLRP3 derived IL-1beta via activating succinate and HIF -1 in rheumatoid arthritis rats."

32413739

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➶

reach

"In this study, cinnamaldehyde and allopurinol inhibited NLRP3 inflammasome activation to reduce IL-1beta release and TGF-beta and Smads signaling in animal and cell models."

27270216

(E)-cinnamaldehyde affects IRF3

| 2

(E)-cinnamaldehyde inhibits IRF3. 2 / 2

| 2

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reach

"Cinnamaldehyde did not inhibit the activation of NFkappaB or IRF3 induced by MyD88 dependent (MyD88, IKKbeta) or TRIF dependent (TRIF, TBK1) downstream signaling components."

17920563

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➶

reach

"Our results showed that cinnamaldehyde suppressed the activation of NFkappaB and IRF3 induced by LPS, a TLR4 agonist, leading to the decreased expression of target genes such as COX-2 and IFNbeta in macrophages (RAW264.7)."

17920563

(E)-4-hydroxynon-2-enal affects TLR7

| 2

(E)-4-hydroxynon-2-enal inhibits TLR7. 2 / 2

| 2

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➶

reach

"As shown in XREF_FIG, MDA and 4-HNE significantly reduced TLR7 and its downstream signaling pathway to LC3A/B."

27279075

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➶

reach

"MDA and 4-HNE serve as the second hit to disrupt TLR7, which appears to be involved in a feedback system."

27279075

(E)-3-tosylacrylonitrile affects IRF7

| 2

(E)-3-tosylacrylonitrile inhibits IRF7. 2 / 2

| 2

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➶

eidos

"Furthermore , the repression in interferon regulatory factor 7 ( IRF7 ) activity by BAY11-7082 interfered with the development of ONFH simultaneously with the MPSL treatment-induced repression in NF-kappaB activity ."

25384124

---

➶

eidos

"Furthermore , the repression in interferon regulatory factor 7 ( IRF7 ) activity by BAY11-7082 interfered with the development of ONFH simultaneously with the MPSL treatment-induced repression in NF-kB activity ."

25384124

(E)-3-tosylacrylonitrile affects IKBKB

| 1 1

(E)-3-tosylacrylonitrile inhibits IKBKB. 2 / 2

| 1 1

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➶

reach

"Our studies demonstrated that Bay-11-7082, which inhibits both IKK-1 and IKK-2, inhibited induction of CCL5 by Nef."

24658403

---

➶

sparser

"Our studies demonstrated that Bay-11-7082, which inhibits both IKK-1 and IKK-2, inhibited induction of CCL5 by Nef."

24658403

(E)-3-tosylacrylonitrile affects CHUK

| 1 1

(E)-3-tosylacrylonitrile inhibits CHUK. 2 / 2

| 1 1

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➶

sparser

"Our studies demonstrated that Bay-11-7082, which inhibits both IKK-1 and IKK-2, inhibited induction of CCL5 by Nef."

24658403

---

➶

reach

"Our studies demonstrated that Bay-11-7082, which inhibits both IKK-1 and IKK-2, inhibited induction of CCL5 by Nef."

24658403

(20S)-ginsenoside Rg3 affects TRAF6

| 2

(20S)-ginsenoside Rg3 inhibits TRAF6. 2 / 2

| 2

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➶

reach

"Stimulation of TRAF6 and TAK1 degradation and inhibition of JNK/AP -1 signalling by ginsenoside Rg3 attenuates hepatitis B virus replication."

24004833

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➶

reach

"Another mechanistic study revealed that ginsenoside Rg3 downregulated TNF receptor associated factor 6 (TRAF6)/transforming growth factor beta activated kinase-1 (TAK1) and inhibited the mitogen activated protein kinase (MAPK) signaling pathway by impeding c-Jun phosphorylation and reducing AP-1 expression."

27746682

(-)-epigallocatechin 3-gallate affects TICAM1

| 2

(-)-epigallocatechin 3-gallate inhibits TICAM1. 2 / 2

| 2

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➶

reach

"Additional studies showed that EGCG, luteolin and structural analogs of luteolin such as quercetin, chrysin, and eriodictyol, also inhibited TRIF signaling pathway by targeting TBK1 kinase [XREF_BIBR, XREF_BIBR]."

21631512

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➶

reach

"However, it is not known whether EGCG inhibits TRIF dependent pathway through which more than 70% of lipopolysaccharide (LPS)-induced genes are regulated."

16890209

(-)-epigallocatechin 3-gallate affects NLRP3

| 2

(-)-epigallocatechin 3-gallate inhibits NLRP3. 2 / 2

| 2

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reach

"Citral and epigallocatechin-3-gallate (EGCG), both bioactive compounds derived from traditional Chinese medicine, prevent NLRP3 activation in vivo in mouse models of lupus and improve nephritis by protecting cells from oxidative damage."

28374568

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➶

reach

"Furthermore, EGCG inhibited renal NLRP3 inflammasome activity, and the expressions of NLRP3, caspase-1, and IL-1beta were also reduced, possibly due to the EGCG induced attenuation of NFkappaB pathway activity."

27672241

(-)-epigallocatechin 3-gallate affects NFKBIA

| 2

(-)-epigallocatechin 3-gallate inhibits NFKBIA. 2 / 2

| 2

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➶

reach

"Studies have showed that EGCG blocked the activation of NF-kappaB by inhibiting the degradation of IkappaBalpha and also inhibited the MAPK pathways."

26379683

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➶

reach

"The catalytic activities of the 20S/26S proteasome complex were inhibited by EGCG, resulting in intracellular accumulation of IkBalpha and subsequent inhibition of NFkappaB activation."

21827739

(-)-epigallocatechin 3-gallate affects NFKB1

| 2

(-)-epigallocatechin 3-gallate inhibits NFKB1. 2 / 2

| 2

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➶

reach

"Recently, we have found that the major tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) suppresses extracellular signals and cell proliferation through epidermal growth factor receptor binding in human A431 epidermoid carcinoma cells; EGCG also blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide induced activity of the transcription factor NFKB in macrophages."

10509743

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➶

reach

"EGCG also blocks LPS induction of nitric oxide synthase in mouse macrophages, by down-regulating the LPS induced activity of the transcription factor NF-KB [8]."

12095176

(-)-epigallocatechin 3-gallate affects MAP3K7

| 2

(-)-epigallocatechin 3-gallate inhibits MAP3K7. 2 / 2

| 2

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➶

reach

"We have shown recently that EGCG inhibits TAK1 kinase activity by occupying C174 site with H-bonds that results in reversible, yet stable inhibition of TAK1 kinase activity (Singh et al., 2016)."

28532672

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➶

reach

"EGCG alone inhibited 50% of p-TAK1 (Thr 184/187)."

28532672

(-)-epigallocatechin 3-gallate affects CHUK

| 2

(-)-epigallocatechin 3-gallate inhibits CHUK. 2 / 2

| 2

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➶

reach

"EGCG has been shown to inhibit IkappaB Kinase (IKK) activity, IkappaB-alpha phophorylation and NF-kappaB activation in intestinal epithelial cells, respiratory epithelial cells, endothelial cells, and in mast cells."

20462508

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➶

reach

"We have also shown that EGCG inhibits IKK-alpha and IKK-beta activity in SAOS-2 cells with concominant down regulation of NF-kappaB and induction of apoptosis."

20462508

(+)-alpha-viniferin affects STAT1

| 2

(+)-alpha-viniferin inhibits STAT1. 2 / 2

| 2

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➶

reach

"Alpha-Viniferin suppresses the signal transducer and activation of transcription-1 (STAT-1)-inducible inflammatory genes in interferon-gamma-stimulated macrophages."

20424383

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➶

reach

"Furthermore, alpha-viniferin powerfully inhibited the signal transducer and activators of transcription 1 (STAT1) inducible inflammatory genes via suppressing ERK mediated STAT1 activation in interferon-gamma-stimulated macrophages [XREF_BIBR]."

24799982

(+)-alpha-tocopherol affects NFKB1

| 2

(+)-alpha-tocopherol inhibits NFKB1. 2 / 2

| 2

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reach

"When Jurkat cells were treated with okac acid subsequent to the preincubation with vitamin E derivatives, only a-tocopheryl succinate but not any other vitamin E derivatives were found to inhibit the NF-KB activation (Fig 4)."

8264337

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➶

reach

"Vitamin E promotes a barrier function and anti-inflammatory responses by binding the regulatory domain of protein kinase Calpha (pkcalpha) (a regulator and antagonist of heart failure) and decreases the activation of NF-kb, a proinflammatory transcription factor, causing the generation of cytokines and chemokines and mast cell activation."

29504360

(+)-alpha-tocopherol affects IKBKB

| 2

(+)-alpha-tocopherol inhibits IKBKB. 2 / 2

| 2

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➶

reach

"Moreover, TNF-alpha-enhanced IKK-beta activity was also inhibited by (polyethylene glycol) PEG-catalase, N-acetylcysteine (NAC), and vitamin E."

25463279

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➶

reach

"Moreover, vitamin E deficiency down-regulated antimicrobial peptides (Hepcidin, liver expressed antimicrobial peptide-2A, -2 B, beta-defensin), IL-10, TGFbeta1, IkappaBalpha, TOR and S6K1 mRNA levels (P < 0.05) and up-regulated IL-1beta, IL-6, IL-8, IFN-gamma2 and TNFalpha, NF-kappaB p65, IKKalpha, IKKbeta and 4EBP1 (not in the head kidney) mRNA levels (P < 0.05)."

27888132

N'-(1,8-dimethyl-4-imidazo[1,2-a]quinoxalinyl)ethane-1,2-diamine affects RELA

| 2

N'-(1,8-dimethyl-4-imidazo[1,2-a]quinoxalinyl)ethane-1,2-diamine inhibits RELA. 2 / 2

| 2

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➶

reach

"BMS345541, an inhibitor of IKKbeta and NFkappaBp65, significantly inhibited the IL-13 and pIKKbeta-induced upregulation of NFkappaBp65 in co-cultured ESF cells (XREF_FIG)."

27073433

---

➶

reach

"The growth factors induced a clearly visible p65 nuclear accumulation (XREF_FIG), which is blocked by BMS345541 (XREF_FIG)."

28358917

4'-epidoxorubicin affects RELA

| 2

4'-epidoxorubicin inhibits RELA. 2 / 2

| 2

---

➶

reach

"We note that disruption of PPI between Foxp3 and p65 by epirubicin might, partially at least, contribute to the modulation of Treg function."

27284967

---

➶

reach

"Interestingly, immunoprecipitation using anti-Foxp3 antibody revealed that epirubicin treatment decreased the amount of p65 protein associated with Foxp3 (XREF_FIG), indicating that epirubicin inhibited the physical interaction between Foxp3 and p65 without modulating their expression."

27284967

3,3',5-triiodo-L-thyronine affects NLRP3

| 2

3,3',5-triiodo-L-thyronine inhibits NLRP3. 2 / 2

| 2

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➶

reach

"In conclusion, T3 alleviates the damage caused by ALD and its role may be associated with the fact that T3 negatively regulates the NLRP3 signaling pathway, thereby downregulating IL-1beta and TGF-beta1 and reducing the activation of stellate cells."

30186412

---

➶

reach

"In conclusion, T3 may reduce the inflammatory response and severity of liver cirrhosis in mice with ALD by negatively regulating the NLRP3 signaling pathway."

30186412

3',5'-cyclic AMP affects TRAF3

| 2

3',5'-cyclic AMP inhibits TRAF3. 2 / 2

| 2

---

➶

reach

"In nerve growth factor induced PC12 cells, cAMP inhibited c-Raf-1, but not B-Raf, while MAP kinases were activated."

9512670

---

➶

reach

"However, cAMP was reported to either inhibit C-Raf-1 or activate B-Raf."

28106114

3',5'-cyclic AMP affects STAT1

| 2

3',5'-cyclic AMP inhibits STAT1. 2 / 2

| 2

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➶

reach

"CAMP signaling inhibited Stat1 at several different levels, including suppression of DNA binding and down-regulation of Stat1 protein and mRNA levels."

8759721

---

➶

reach

"Inhibition of transcription factor Stat1 activity in mononuclear cell cultures and T cells by the cyclic AMP signaling pathway."

8759721

3',5'-cyclic AMP affects RELA

| 2

3',5'-cyclic AMP inhibits RELA. 2 / 2

| 2

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➶

reach

"The possibility was discussed that (p) ppGpp and cAMP both positively affect transcription of the genes encoding the acid sensitization components; in accord with this, high concentrations of cAMP suppressed the effect of the relA lesion of sensitization."

8676748

---

➶

reach

"Interestingly, PGE2 or di-butyryl (Bt2) cAMP abolished the binding of NF-kappa B (p50 and p65) heterodimer to the kappa B sequence in cells stimulated with anti-CD3 mAb but not with PMA and A23187."

8018594

3',5'-cyclic AMP affects IKBKB

| 1 1

3',5'-cyclic AMP inhibits IKBKB. 2 / 2

| 1 1

---

➶

eidos

"CAMP inhibits IKKbeta , decreasing IkappaB phosphorylation , ubiquitination , and degradation [ 147 , 157 ] ."

32715279

---

➶

reach

"CAMP inhibits IKKbeta, decreasing IkappaB phosphorylation, ubiquitination, and degradation [XREF_BIBR]."

32715279

Zinc atom affects OAS1

| 1 1

Zinc atom inhibits OAS1. 1 / 1

| 1

---

➶

sparser

"Even though both OAS1 and OAS2 are strongly inhibited by zinc and by other metal ions as well, only OAS1 displays some co-operativity in the metal ion-mediated inhibition."

11682059

Zinc atom inhibits OAS1. 1 / 1

| 1

---

➶

reach

"In contrast, the inhibition of OAS1 by Zn 2+ had a Hill coefficient of 1.8, indicating co-operative binding of Zn 2+ with at least two binding sites on the molecule.OAS1 has previously been reported to exist in an oligomeric state [27]."

11682059

Triterpenoid affects NFKBIA

| 1 1

Triterpenoid inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB regulated gene products in human leukemic cells."

16551868

Triterpenoid inhibits NFKBIA. 1 / 1

| 1

---

➶

sparser

"A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells."

16551868

Trichostatin A affects STAT1

1 | 1

Trichostatin A inhibits STAT1. 1 / 1

| 1

---

➶

reach

"OSM, an IL-6 family cytokine, signals through the STAT pathway; recent reports show that HDAC activity plays an essential role in at least STAT1 signalling, and that TSA can therefore abrogate STAT1 induced gene expression [XREF_BIBR, XREF_BIBR]."

15899037

Trichostatin A inhibits STAT1. 1 / 1

1 |

---

➶

bel

"inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma-induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation."

15123634

Inosine affects IRF3

| 2

Inosine inhibits IRF3. 1 / 1

| 1

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➶

reach

"In addition, recent studies showed that inosine containing dsRNAs can inhibit activation of IRF3 and therefore the downstream interferon signaling pathway, possibly by functioning as competitive inhibitors of RIG-I and MDA5 [17]."

22960755

Inosine inhibits IRF3. 1 / 1

| 1

---

➶

reach

"In addition, recent studies showed that inosine containing dsRNAs can inhibit activation of IRF3 and therefore the downstream interferon signaling pathway, possibly by functioning as competitive inhibitors of RIG-I and MDA5 [XREF_BIBR]."

22960755

Hyaluronic acid affects NFKB1

| 2

Hyaluronic acid inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"At IC 50, 4-MU also caused> 90% inhibition of NFkB reporter activity which was prevented partially by HA addition."

20332231

Hyaluronic acid bound to TLR4 inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Diminished apoptosis resulting from NFkB activation induced by binding of HA to TLR4 was described in bleomycin induced apoptosis in mouse alveolar epithelial cells."

31484704

Cyclooctasulfur affects DDX58

| 2

Cyclooctasulfur inhibits DDX58-K96R. 1 / 1

| 1

---

➶

reach

"In addition, mutation of S8 and T170 to alanines rescued the impaired ability of RIG-I (K96R) to activate the IFN-beta promoter, respectively."

28250012

Cyclooctasulfur inhibits DDX58. 1 / 1

| 1

---

➶

reach

"Mutational analysis indicated that while the phosphorylation of S8 or T170 potently inhibits RIG-I downstream signaling, the dephosphorylation of RIG-I at both residues is necessary for optimal TRIM25 binding and ubiquitination mediated RIG-I activation."

22114345

Celastrol affects CHUK

| 1 1

Celastrol inhibits CHUK. 1 / 1

| 1

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➶

sparser

"Celastrol (i) inhibits directly the IKKalpha and beta kinases, (ii) inactivates the Cdc37 and p23 proteins which are co-chaperones of HSP90, (iii) inhibits the function of proteasomes, and (iv) activates the HSF1 and subsequently triggers the heat shock response."

20226165

Celastrol inhibits CHUK. 1 / 1

| 1

---

➶

reach

"Celastrol is a quinone methide triterpene inhibiting directly kinases IKKalpha and IKKbeta and inactivates CDC37 (cell division cycle 37) and p23 (prostaglandin E synthase 3) proteins and is thus an HSP90 (heat-shock protein 90 kDa) inhibitor."

26775695

Auranofin affects CHUK

| 2

Auranofin inhibits CHUK-S180E. 1 / 1

| 1

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➶

reach

"Auranofin inhibited constitutively active IKKalpha and beta and variants; IKKalpha (S176E, S180E) or IKKbeta (S177E, S181E), suggesting that gold directly cause inhibition of activated enzyme."

12754408

Auranofin inhibits CHUK-S176E. 1 / 1

| 1

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➶

reach

"Auranofin inhibited constitutively active IKKalpha and beta and variants; IKKalpha (S176E, S180E) or IKKbeta (S177E, S181E), suggesting that gold directly cause inhibition of activated enzyme."

12754408

Antagonist affects TLR7

| 1 1

Antagonist inhibits TLR7. 1 / 1

| 1

---

➶

eidos

"Furthermore , the antagonist abolished the Tlr7 / 9-enhanced LDL uptake ."

| PMC

Antagonist inhibits TLR7. 1 / 1

| 1

---

➶

sparser

"The use of A151, an oligonucleotide described as a TLR antagonist inhibiting TLR7 and, to a lesser extent, TLR9 did not inhibit IFN-α/β induction by UV-BTV, indicating that UV-BTV activates IFN-α/β production via a TLR7/8-independent mechanism."

24211608

Antagonist affects NLRP3

| 1 1

Antagonist inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Among the latter, anakinra is the recombinant form of the IL-1 receptor antagonist, known to inhibit NLRP3 via blockade of the IL-1 receptor I. Anakinra is currently used to treat a wide range of diseases that goes beyond its approved indications for rheumatoid arthritis and cryopyrin-associated periodic syndromes, to encompass cancer and chronic inflammatory diseases 9 ."

32547788

Antagonist inhibits NLRP3. 1 / 1

| 1

---

➶

sparser

"These findings indicate different kinetic modes of AII inhibition by these two antagonists."

2918473

Acrolein affects JUN

1 | 1

Acrolein inhibits JUN. 1 / 1

| 1

---

➶

sparser

"It is apparent that the activation of the transcription factors nuclear factor kappa B (NF-kappa B) and activator protein 1 (AP-1) can be inhibited by acrolein."

10966506

Acrolein inhibits JUN. 1 / 1

1 |

---

➶

ctd

No evidence text available

11849044

PHA-665752 affects TBK1

2 |

PHA-665752 inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

PHA-665752 inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

PHA-665752 affects IKBKE

2 |

PHA-665752 inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

PHA-665752 inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Gly-Asn affects IFNB1

| 2

Modified Gly-Asn inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"The ectopic expression of the hantaviral glycoprotein Gn, from the pathogenic New York-1 virus (NY-1V), was reported to inhibit IRF-3 phosphorylation as well as IRF-3-directed transcriptional response of IFN-beta promoter."

24129118

Gly-Asn inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"In contrast, the Gn tail of the nonpathogenic hantavirus Prospect Hill virus (PHV) failed to coprecipitate TRAF3 or inhibit NF-kappaB or IFN-beta transcriptional responses."

18614628

N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide affects MAPK14

1 1 |

N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

18789685

3',5'-cyclic AMP affects FOS

| 2

3',5'-cyclic AMP inhibits FOS. 1 / 1

| 1

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➶

reach

"(ii) It is reported that cAMP mediated suppression of p65 transcriptional activation is impaired in c-Fos deficient cells."

27374176

Modified 3',5'-cyclic AMP inhibits FOS. 1 / 1

| 1

---

➶

reach

"The high levels of cAMP induced ICER expression dramatically reduced a second induction of c-fos."

9544985

Zoledronic acid affects NFKBIA

| 1

Zoledronic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"In our previous study, we have revealed that Zol activated NF-kappaB by enhancing IkappaB-alpha degradation suggesting the involvement of M1 polarized macrophages [XREF_BIBR]."

29977413

Zoledronic acid affects MAP3K7

| 1

Zoledronic acid inhibits MAP3K7. 1 / 1

| 1

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➶

reach

"Consistent with in vitro cell culture data, either ZOL inhibition of TAK1 or CD40 deficiency profoundly attenuated p65 phosphorylation in the medial VSMCs of injured femoral arteries (XREF_FIG)."

25050617

Zoledronic acid affects ITCH

| 1

Zoledronic acid inhibits ITCH. 1 / 1

| 1

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➶

reach

"Clomipramine causes osteoporosis by promoting osteoclastogenesis via E3 ligase Itch, which is prevented by Zoledronic acid."

28145497

Zoledronic acid affects IRF3

| 1

Zoledronic acid inhibits IRF3. 1 / 1

| 1

---

➶

medscan

"Increasing Zoledronic acid concentrations downregulated nuclear factor-kappaB family members and interferon-regulatory factor -3."

17301819

Zinc sulfate affects RELA

1 |

Zinc sulfate inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

16606632

Zinc atom affects TICAM1

| 1

Zinc atom inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"To understand whether Zn inhibited MyD88 or TRIF signaling, or both, we queried whether Zn suppressed the proinflammatory response of DCs to TLR2 and TLR3 ligands."

27465530

Zinc atom affects STAT1

1 |

Zinc atom inhibits STAT1. 1 / 1

1 |

---

➶

ctd

No evidence text available

28086195

Zinc atom affects NFKBIA

| 1

Zinc atom inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"The lowest concentration of Zn 2+ (1 mug/mL) was also able to induce IkappaBalpha degradation in prestimulated cells."

27695324

Zinc atom affects JUN

| 1

Zinc atom inhibits JUN. 1 / 1

| 1

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➶

reach

"A decrease in extracellular Zn concentration increases the activation of the oxidant sensitive transcription factor AP-1 through a mechanism involving NMDAR and NADPH oxidase."

20211250

Zinc atom affects IRF3

| 1

Zinc atom inhibits IRF3. 1 / 1

| 1

---

➶

sparser

"Based on results using other stimuli, the authors suggest that zinc can inhibit IRF3-, and perhaps IRF7-dependent IFNB production, by limiting activation and/or nuclear translocation (138)."

31305906

Zinc atom affects EIF2AK1

1 |

Zinc atom inhibits EIF2AK1. 1 / 1

1 |

---

➶

ctd

No evidence text available

17689536

Zileuton affects IFNB1

| 1

Zileuton inhibits IFNB1. 1 / 1

| 1

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➶

reach

"Treating mice with prostaglandin E2 and zileuton, which limit IFNbeta induction, confers tolerance to Mtb [XREF_BIBR] and zileuton has been developed as a drug that can be administered to TB patients to enhance the efficacy of antibiotic treatment [XREF_BIBR]."

27500737

Zidovudine affects NLRP3

| 1

Zidovudine inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Moreover, a significant reduction of the Nlrp3 transcript levels in AZT-mdx muscle confirmed the Fowler et al., [XREF_BIBR] data that AZT suppresses the Nlrp3 inflammasome by blocking P2RX7activity (Nlrp3 : AZT-mdx vs PBS-mdx p = 0.03)."

29642926

Zidovudine affects IFNB1

| 1

Zidovudine inhibits IFNB1. 1 / 1

| 1

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➶

reach

"AZT and NVP, even at high concentrations, did not inhibit IFNbeta induction by HT-DNA (XREF_SUPPLEMENTARY), indicating that the inhibitory effects of AZT and NVP were due to their specific inhibition of HIV reverse transcription."

23929945

Zidovudine affects FOS

| 1

Zidovudine inhibits FOS. 1 / 1

| 1

---

➶

sparser

"Simultaneous treatment of erythroid progenitor cells with Epo or a combination of Epo and IL-3 reversed the AZT-induced inhibition of c-fos protooncogene transcription."

7646543

Zerumbone affects RELA

1 |

Zerumbone inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

16007145

Zerumbone affects NFKBIA

| 1

Zerumbone inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion."

16007145

Zerumbone affects NFKB1

1 |

Zerumbone inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

16007145

Zafirlukast affects MAPK14

1 |

Zafirlukast inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

Wortmannin affects MAPK8

| 1

Wortmannin inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"Our data showed that extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059, but not the c-Jun N-terminal kinase (JNK) inhibitor SP600125, p38 kinase inhibitor SB203580, and PI3K inhibitor wortmannin, attenuated Src-induced MMP-2 promoter activity."

16453304

Wogonin affects JAK1

| 1

Wogonin inhibits JAK1. 1 / 1

| 1

---

➶

reach

"Wogonin efficiently suppressed IL-4-induced JAK1 and STAT6 activation in bronchial epithelial cells and attenuated OVA induced airway inflammation."

26388667

Wogonin affects FOS

| 1

Wogonin inhibits FOS. 1 / 1

| 1

---

➶

reach

"Further, purified Wogonin suppressed the IL-1beta-induced activation of c-Fos in OA chondrocytes (XREF_FIG)."

28256567

Withanolide affects MAP3K7

| 1

Withanolide inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"Chemokine receptor CCR7 is important for lymphatic invasion of cancer cells and is overexpressed in metastatic breast cancer cells; withanolide inhibits TAK1 to repress NF-kappaB-induced CCR7 expression in breast cancer cells and is useful for the prevention of lymphatic involvement by breast cancer cells [XREF_BIBR]."

22069560

Withaferin A affects RELA

| 1

Withaferin A inhibits RELA. 1 / 1

| 1

---

➶

reach

"Withaferin A pretreatment also reduced binding of BRG1 and the NF-kappaB subunit p65 to CNSa (XREF_FIG)."

21831442

Wedelolactone affects RELA

1 |

Wedelolactone inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

26422990

Wedelolactone affects NLRP3

| 1

Wedelolactone inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"We found that wedelolactone broadly inhibited NLRP3 inflammasome activation and pyroptosis and IL-1beta secretion."

32656909

Water affects CASP1

| 1

Water inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Water immersion significantly reduced the amplitudes of the short-latency SEP components P25 and P45 measured from electrodes over the parietal region and the P45 measured by central region."

22272934

Vortioxetine affects FOS

| 1

Vortioxetine inhibits FOS. 1 / 1

| 1

---

➶

reach

"Furthermore, chronic administration of fluoxetine and vortioxetine decreased Arc and c-Fos, but not Egr1 in the frontal cortex, hippocampus and amygdala of rodents."

29755331

Vorinostat affects NFKBIA

| 1

Vorinostat inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Furthermore, SAHA inhibited the NF-kappaB-dependent reporter gene expression activated by TNF, TNFR1, TRADD, TRAF2, NF-kappaB-inducing kinase, IkappaBalpha kinase, and the p65 subunit of NF-kappaB."

16377638

Vorinostat affects ITCH

| 1

Vorinostat inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Moreover, Yerbes and Lomicronpez-Rivas also reported that a histone deacetylase inhibitor suberoylanilide hydroxamic acid induced the Itch independent proteasomal degradation of both cFLIP L and cFLIP S and sensitized breast tumor cells to TRAIL [XREF_BIBR]."

26694384

Vorinostat affects IKBKG

1 |

Vorinostat inhibits IKBKG. 1 / 1

1 |

---

➶

ctd

No evidence text available

19509267

Vitexin-7-olate affects JAK1

| 1

Vitexin-7-olate inhibits JAK1. 1 / 1

| 1

---

➶

reach

"Vitexin effectively inhibited sustained activation of JAK1, JAK2, Src, and STAT3 in HCC cells."

32445654

Vitamin C affects NLRP3

| 1

Vitamin C inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Indeed, vitamin C, vitamin D, and omega-3 fatty acids have all been shown to inhibit the NLRP3 inflammasome and may work synergistically against the cytokine storm associated with COVID-19 and specifically against the neuro-inflammation associated with its delirium (67, 68, 69)."

| PMC

Vincristine affects TRAF3

| 1

Vincristine inhibits TRAF3. 1 / 1

| 1

---

➶

reach

"Tat as well as soluble CD154 (sCD154) prevented vincristine induced reduction of TRAF-3 in KS cells transfected with a vector for neomycin resistance (KS psv-neo), but not in KS sCD40."

16569346

Vincristine affects IRF7

| 1

Vincristine inhibits IRF7. 1 / 1

| 1

---

➶

reach

"In comparison to the control group, vincristine induced a significant increase of CXCL10, CXCL9, SFRP2, and PF4 mRNA and an obvious reduction in IRF7 mRNA in primary microglia (XREF_FIG)."

30881521

Vincaleukoblastine affects STAT1

1 |

Vincaleukoblastine inhibits STAT1. 1 / 1

1 |

---

➶

ctd

No evidence text available

28086195

Vemurafenib affects JUN

| 1

Vemurafenib inhibits JUN. 1 / 1

| 1

---

➶

reach

"BET inhibitors reduced c-Jun up-regulation induced by vemurafenib to a significant degree (by an average of ~ 50%; P < 2x10 -8) but did not fully block it (Fig XREF_FIG D)."

28069687

Vasopressin affects FOS

| 1

Vasopressin inhibits FOS. 1 / 1

| 1

---

➶

reach

"Inhibition of the sustained phase of ERK and RSK activation abrogated the increase in c-Fos accumulation and DNA synthesis induced by bombesin or vasopressin in PKD overexpressing cells."

14963034

Vanillic acid affects CASP1

| 1

Vanillic acid inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Moreover, vanillic acid suppressed the activation of nuclear factor-kappa B (NF-kappaB) and caspase-1."

21250779

Vanadium atom affects IFNB1

| 1

Vanadium atom inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Another lung toxic metal, vanadium pentoxide (V 2 O 5), causes a slow, oxidant dependent increase in IFN-b protein to activate STAT1 signaling pathways."

19994902

Valsartan affects MAPK14

| 1

Valsartan inhibits MAPK14. 1 / 1

| 1

---

➶

reach

"In the EXPLOR Study, the combination of amlodipine and valsartan lowered CSBP to a larger extent than amlodipine and atenolol in combination [XREF_BIBR]."

28127560

Valproic acid affects NFKB1

| 1

Valproic acid inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Valproic acid downregulates NF-kappaB p50 activity and IRAK-1 in a progressive thyroid carcinoma cell line."

24526373

Valproic acid affects IRF7

| 1

Valproic acid inhibits IRF7. 1 / 1

| 1

---

➶

reach

"To determine if chromatin structure plays a critical role in the regulation of IRF7, GEN2.2 cells were treated with HDAC inhibitor, valproic acid (VPA)."

27630164

Valeric acid affects ITCH

| 1

Valeric acid inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Betamethasone valerate 0.1%-impregnated occlusive tape significantly decreased itch compared with an antipruritic moisturizing cream containing feverfew, a traditional medicinal herb."

30881076

Valeric acid affects CASP1

| 1

Valeric acid inhibits CASP1. 1 / 1

| 1

---

➶

reach

"The caspase-1 (interleukin 1beta converting enzyme; ICE) titrant 3-[2-(2-benzyloxycarbonylamino-3-methylbutyrylamino) propionylamino] -4 -oxo-5-(2-oxo-2H-chromen-7-yloxy) pentanoic acid (1 (Dang, L. C., et al. (1996) Biochemistry 35, 14910-14916)) inhibits caspase-1 activity rapidly, while release of the 7-hydroxycoumarin fluorophore is much slower."

9622503

Ursolic acid affects RELA

| 1

Ursolic acid inhibits RELA. 1 / 1

| 1

---

➶

reach

"Ursolic acid also inhibited NF-kappaB-dependent reporter gene expression activated by TNF receptor (TNFR), TNFR associated death domain (TRADD), TNFR associated factor (TRAF), NF-kappaB-inducing kinase (NIK), IKK, and p65 [XREF_BIBR]."

22069560

Ursolic acid affects NFKBIA

| 1

Ursolic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

sparser

"The most important component of P. orientalis is caffeic acid and its derivatives, rosmarinic acid which is able to inhibit the production of leukotriene B4 in human polymorphonuclear leucocytes (Al-Sereiti et al., 1999 xref ) and ursolic acid which inhibits the nuclear transcription factor kappaB (nfK-B) (Aggarwal and Shishodia, 2004 xref )."

| PMC

Ursolic acid affects NFKB1

| 1

Ursolic acid inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Recently, several in vitro studies have indicated that ursolic acid inhibits NFkB activation through suppression of IkBalpha kinase and p65 phosphorylation (Shishodia et al., 2003; Zeng et al., 2011) and selectively inhibits RORgammat function, greatly reducing IL-17 expression in developing and differentiated Th17 cells (Xu et al., 2011), significantly reducing MMP-2 and MMP-9 enzymatic activity (Cha et al., 2011), and inhibiting the STAT3 activation pathway (Pathak et al., 2007)."

23201068

Ursolic acid affects JUN

| 1

Ursolic acid inhibits JUN. 1 / 1

| 1

---

➶

reach

"The combination of ursolic acid + resveratrol inhibited TPA induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds."

26100520

Urea affects IKBKB

| 1

Urea inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Recent studies by us also suggest that the quinoxaline urea analog 13-197 inhibits the constitutively active form of IKKbeta which is an emerging target for therapeutic development."

23963361

Tyrphostin AG 1478 affects RELA

| 1

Tyrphostin AG 1478 inhibits RELA. 1 / 1

| 1

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➶

reach

"XREF_FIG, XREF_FIG demonstrated that blocking EGFR activity by pretreatment with AG1478 could significantly attenuate the activation of NF-kappaB p65 subunit and ERK1/2, as well as retarding the IkappaBalpha degradation by SS2 infection."

27756321

Tyrphostin AG 1478 affects MAPK14

1 |

Tyrphostin AG 1478 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

15454232

Tyrphostin AG 1478 affects JUN

| 1

Tyrphostin AG 1478 inhibits JUN. 1 / 1

| 1

---

➶

reach

"Both c-Fos and c-Jun induction by EGF was completely abolished by AG1478 (data not shown), whereas neither c-Fos nor c-Jun expression by PDGF was affected by AG1478."

10440105

Tyrphostin AG 1478 affects FOS

| 1

Tyrphostin AG 1478 inhibits FOS. 1 / 1

| 1

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➶

reach

"Both c-Fos and c-Jun induction by EGF was completely abolished by AG1478 (data not shown), whereas neither c-Fos nor c-Jun expression by PDGF was affected by AG1478."

10440105

Tropanyl 3,5-dimethylbenzoate affects FOS

| 1

Tropanyl 3,5-dimethylbenzoate inhibits FOS. 1 / 1

| 1

---

➶

reach

"Genova and Hyman (1998) reported that the 5-HT 3 receptor antagonist MDL-72222 blocked c-Fos and that phosphorylation of cAMP response element binding protein (CREB) and activation of transcription factor-1 (ATF-1) by serotonin requires 5-HT 3 receptor activation and Ca 2+."

12398913

Troglitazone affects NFKB1

1 |

Troglitazone inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

17425601

Troglitazone affects JUN

| 1

Troglitazone inhibits JUN. 1 / 1

| 1

---

➶

reach

"A luciferase reporter assay showed that troglitazone inhibited not only the transcriptional activation of the HMGB1 promoter but also activities of heterologous promoters driven by nuclear factor kappaB (NF-kappaB) or activator protein 1 (AP-1) response elements."

21617575

Troglitazone affects IFNB1

| 1

Troglitazone inhibits IFNB1. 1 / 1

| 1

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➶

reach

"The ability of the PPAR-gamma agonist to inhibit IFN-beta production was confirmed in vivo as mice treated with troglitazone exhibited decreased levels of IFN-beta upon LPS and poly (I : C) challenge."

21148557

Tris affects STING1

| 1

Tris inhibits STING1. 1 / 1

| 1

---

➶

medscan

"After washing with TNE buffer, STING protein was eluted using Elution buffer (pH 2.8, Thermo) and then neutralized by Tris-HCl (pH 9.5)."

24119841

Triptorelin affects FOS

| 1

Triptorelin inhibits FOS. 1 / 1

| 1

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➶

reach

"XREF_BIBR - XREF_BIBR Triptorelin was shown to reduce the E2 related activation of c-fos with a subsequent reduction in the transcriptional activity and downregulation of cancer cell proliferation."

29551913

Trioxsalen affects JUN

1 |

Trioxsalen inhibits JUN. 1 / 1

1 |

---

➶

ctd

No evidence text available

16259964

Trimethylamine affects MAP3K7

| 1

Trimethylamine inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"TAK1 deletion is detected in the skin of ER-TAK fl/fl mice treated with TMA but not the ones treated with mock."

21552285

Triethyl phosphate affects RELA

| 1

Triethyl phosphate inhibits RELA. 1 / 1

| 1

---

➶

reach

"The p65 translocation to the nucleus was markedly reduced in 293T cells treated with TEP for 48 h."

32256797

Tridecane affects NFKB1

| 1

Tridecane inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Notably, there are reports that TRD inhibits the activation of NFKB not only indirectly through NFKBIA but, also by direct interference, by oxidation of NFKB at Met45 [XREF_BIBR]."

19077262

Trichostatin A affects STING1

| 1

Trichostatin A inhibits STING1. 1 / 1

| 1

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➶

reach

"To test if the compaction induced by NET23 and STING is reversible, the stable inducible line was treated with TSA with or without induction of the NET23 and STING with doxycycline."

25386906

Trichostatin A affects PYCARD

| 1

Trichostatin A inhibits PYCARD. 1 / 1

| 1

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➶

reach

"Histone deacetylases (HDACs) inhibitor TSA suppressed injury induced ASC in the mouse lens capsular injury model."

25666271

Trichostatin A affects MAP3K7

| 1

Trichostatin A inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"To determine whether nuclear factor-kappaB (NF-kappaB) is constitutively and tumor necrosis factor (TNF)-dependently activated in endometriotic cells, whether trichostatin A (TSA) can suppress NF-kappaB activation and suppress TRAF2/6 and TAK1, and whether TSA and caffeic acid phenyl ester can suppress constitutive and H (2) O (2)-stimulated proliferation of endometriotic cells."

20130413

Trichostatin A affects IRF9

| 1

Trichostatin A inhibits IRF9. 1 / 1

| 1

---

➶

sparser

"We also show that the TSA-dependent inhibition of ISGF3 is related to impaired nuclear accumulation of STAT2."

12768031

Trichostatin A affects IRF7

| 1

Trichostatin A inhibits IRF7. 1 / 1

| 1

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➶

reach

"23 TSA, a histone deacetylase inhibitor, is known to inhibit IRF7 activity."

27567430

Tribromosalicylanilide affects TRAF3

| 1

Tribromosalicylanilide inhibits TRAF3. 1 / 1

| 1

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➶

reach

"By removing the CD40 TBS and the ability of TBS associated factors to bind CD40, TBS independent factors may be able to more efficiently bind CD40 and mediate TRAF3 degradation."

19667091

Tribromosalicylanilide affects PYCARD

| 1

Tribromosalicylanilide inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Our results confirm that consistent application of TBS 2001 terminology for ASC reduces the ASC rate, and better identifies women at high risk for CIN 2, 3, and SCC."

16355376

Tribromosalicylanilide affects NFKBIA

| 1

Tribromosalicylanilide inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"As shown in XREF_FIG, the activation of IkappaB-alpha via phosphorylation significantly (p < 0.001) increased in LPS stimulated RAW 264.7 cells, whereas CBS and TBS extracts inhibited the activation of IkappaB-alpha."

28928906

Tribromosalicylanilide affects MAPK14

1 |

Tribromosalicylanilide inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

Triacetylcellulose affects NLRP3

| 1

Triacetylcellulose inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Triptolide treatment attenuated TAC induced myocardial remodeling, improved cardiac diastolic and systolic function, inhibited the NLRP3 inflammasome and downstream inflammatory mediators (IL-1beta, IL-18, MCP-1, VCAM-1), activated the profibrotic TGF-beta1 pathway, and suppressed macrophage infiltration in a dose dependent manner."

28202417

Trans-resveratrol affects RELA

| 1

Trans-resveratrol inhibits RELA. 1 / 1

| 1

---

➶

medscan

"The results were as follows: (1) resveratrol inhibited the expression of MUC5AC gene induced by EGF or PMA or TNF-α from NCI-H292 cells; (2) resveratrol also inhibited the production of MUC5AC mucin protein induced by the same inducers from NCI-H292 cells; (3) resveratrol inhibited the activation of NF-κB p65 by TNF-α or PMA in NCI-H292 cells; (4) resveratrol significantly decreased adenosine triphosphate-induced mucin secretion from cultured rat tracheal surface epithelial cells."

22213337

Trans-isoeugenol affects NFKBIA

| 1

Trans-isoeugenol inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"These results suggest that isoeugenol and its analogues inhibit NO production and iNOS expression in LPS stimulated RAW 264.7 cells, and that these effects are mediated, at least in part, by blocking the phosphorylation of ERK1/2 and p38 kinase, degradation of I-kappaBalpha, and activation of NF-kappaB."

17698059

Trans-anethole affects IKBKB

1 |

Trans-anethole inhibits IKBKB. 1 / 1

1 |

---

➶

ctd

No evidence text available

10871845

Trans-aconitic acid affects NLRP3

| 1

Trans-aconitic acid inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Acid aspiration induced inflammatory responses and ALI in wild-type mice were significantly attenuated in IL-1beta -/- mice, but not NLRP3 -/- mice."

31109954

Trans-aconitic acid affects NFKBIA

| 1

Trans-aconitic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Acid treatment significantly decreased IkappaBalpha and increased luciferase activity when SEG1 cells were transfected with an NF-kappaB in vivo activation reporter plasmid, pNF-kappaB-Luc."

17403674

Trans-aconitic acid affects JUN

| 1

Trans-aconitic acid inhibits JUN. 1 / 1

| 1

---

➶

reach

"The tRA dependent depletion of c-Jun depends on retinoid nuclear receptors RARgamma and RXRalpha, which are themselves sensitive to UV."

16330259

Trans-aconitic acid affects JAK1

| 1

Trans-aconitic acid inhibits JAK1. 1 / 1

| 1

---

➶

sparser

"Hydrophobic bile acids will inhibit Jak1- and Tyk2-phosphorylation, resulting in a decreased mRNA and protein expression of IFN-stimulated genes such as myxovirus resistance protein A (MxA) or dsRNA-activated protein kinase (PKR) thereby explaining interferon-ɑ resistance [ xref ]."

28292275

Trans-aconitic acid affects ITCH

| 1

Trans-aconitic acid inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Ileal Bile Acid Transporter Inhibition for the Treatment of Chronic Constipation, Cholestatic Pruritus, and NASH."

30186169

Trans-aconitic acid affects IKBKB

| 1

Trans-aconitic acid inhibits IKBKB. 1 / 1

| 1

---

➶

sparser

"In the cell free hotspot kinase assay, the CA, AA and UA inhibited human IKKβ."

25938234

Trans-aconitic acid affects IFIH1

| 1

Trans-aconitic acid inhibits IFIH1. 1 / 1

| 1

---

➶

sparser

"Inhibition of a DNA-helicase by peptide nucleic acids."

9862979

Trabectedin affects NFKB1

| 1

Trabectedin inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Furthermore, trabectedin treatment inhibits in vitro NFkB pathway in mixoyd liposarcoma sensitive but not in resistant counterparts, and the inhibition of NFkB pathway re-sensitizes the resistant cells to trabectedin treatment."

29980789

Tofacitinib affects CASP1

| 1

Tofacitinib inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Tofacitinib, which inhibits GM-CSF-induced Janus kinase 2 (Jak2)-mediated signal transduction, completely abrogated GM-CSF-induced IL-1beta and caspase-1 (p20) secretion from neutrophils."

30157949

Titanium dioxide affects RELA

1 |

Titanium dioxide inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

30320338

Titanium dioxide affects NLRP3

| 1

Titanium dioxide inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Titanium dioxide nanoparticles promote oxidative stress, autophagy and reduce NLRP3 in primary rat astrocytes."

32004531

Titanium atom affects RELA

| 1

Titanium atom inhibits RELA. 1 / 1

| 1

---

➶

reach

"These results indicated that naringin could inhibit Ti particle induced inflammation in fibroblasts by inhibiting p38 MAPK and NF-kappaB p65 activity and might be a potential drug for the treatment of inflammatory periprosthetic osteolysis after arthroplasty."

32500755

Tiotropium bromide affects RELA

| 1

Tiotropium bromide inhibits RELA. 1 / 1

| 1

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➶

reach

"As shown in XREF_FIG, the addition of tiotropium bromide at concentration> 12.5 pg/mL significantly suppressed p50 and p65 activation in BEAS-2B cells, which was increased by LPS stimulation."

22003289

Tiotropium bromide affects NFKB1

| 1

Tiotropium bromide inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"As shown in XREF_FIG, the addition of tiotropium bromide at concentration> 12.5 pg/mL significantly suppressed p50 and p65 activation in BEAS-2B cells, which was increased by LPS stimulation."

22003289

Thymol affects RELA

| 1

Thymol inhibits RELA. 1 / 1

| 1

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➶

reach

"Furthermore, H 2 O 2 treatment increased the phosphorylation of p65 and IkappaBalpha, which were decreased when treated with N-acetyl cysteine or thymol."

28223539

Thymol affects NFKBIA

| 1

Thymol inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Furthermore, H 2 O 2 treatment increased the phosphorylation of p65 and IkappaBalpha, which were decreased when treated with N-acetyl cysteine or thymol."

28223539

Thymine glycol affects IFIH1

| 1

Thymine glycol inhibits IFIH1. 1 / 1

| 1

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➶

sparser

"For example, both RECQL1 and FANCJ helicases are inhibited by thymine glycol residing within the duplex region in either the translocating or non-translocating strand [ xref ], suggesting that these helicases operate by an active mechanism in which they interact with both DNA strands during duplex DNA unwinding."

29273621

Thiophenes affects IKBKB

1 |

Thiophenes inhibits IKBKB. 1 / 1

1 |

---

➶

ctd

No evidence text available

23906629

Thiol affects NFKB1

| 1

Thiol inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Stimulation with TNF decreased intracellular thiols and enhanced NFKB activation, whereas added NAC restored thiol levels and blocked the activation of NFKB."

1770755

Thioglycolate(1-) affects IFNB1

| 1

Thioglycolate(1-) inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Similarly, primary thioglycollate elicited mouse peritoneal macrophages transfected with siRNA targeting DDX41 (XREF_FIG) displayed reduced activation of IFN-beta in response to L. monocytogenes infection or c-di-GMP stimulation compared to control-siRNA transfected cells (XREF_FIG)."

23142775

Thiocyanate affects IRF7

| 1

Thiocyanate inhibits IRF7. 1 / 1

| 1

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➶

reach

"Several viral NCs can block the IFN signal transfer; lymphocytic choriomeningitis virus (LCMV) NCs can block the IFN signal transfer through interfere the function of IKKε; NCs of Andes virus (ANDV) and porcine epidemic diarrhea virus (PEDV) inhibit IFN signal by interfering with function of TBK1 and IRF3; Arenavirus NCs prevent IRF3 from localizing to nucleus and Borna diseae virus (BDV) NCs prevent IRF7 from localizing to nucleus."

26749541

Thiocyanate affects IRF3

| 1

Thiocyanate inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Several viral NCs can block the IFN signal transfer; lymphocytic choriomeningitis virus (LCMV) NCs can block the IFN signal transfer through interfere the function of IKKε; NCs of Andes virus (ANDV) and porcine epidemic diarrhea virus (PEDV) inhibit IFN signal by interfering with function of TBK1 and IRF3; Arenavirus NCs prevent IRF3 from localizing to nucleus and Borna diseae virus (BDV) NCs prevent IRF7 from localizing to nucleus."

26749541

Thiamphenicol affects MAVS

| 1

Thiamphenicol inhibits MAVS. 1 / 1

| 1

---

➶

reach

"Against MRSA thiamphenicol and chloramphenicol were second only to the glycopetides and also inhibited the VISA strains."

12583545

Theophylline affects NFKBIA

| 1

Theophylline inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"In addition, one study of the inflammation suppressing mechanism found that theophylline inhibits NF-kappaB activation by protecting IkappaBalpha, thereby inhibiting the production of proinflammatory cytokines [XREF_BIBR]."

31565900

Theophylline affects FOS

| 1

Theophylline inhibits FOS. 1 / 1

| 1

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➶

reach

"When administered prior to reserpine, theophylline (25 mg/kg) or 3,7-dimethyl-1-propargylxanthine (25 mg/kg) partially attenuate the induction of striatal c-fos."

8577368

Theobromine affects NFKBIA

| 1

Theobromine inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Mechanistically, we show that theobromine inhibits IL-1beta-induced IkappaBalpha activation, nuclear factor-kappaB (NF-kappaB) protein p65 accumulation, and transfected NF-kappaB promoter activity, indicating that theobromine suppresses the NF-kappaB pathway in chondrocytes."

32146317

Theaflavin affects RELA

| 1

Theaflavin inhibits RELA. 1 / 1

| 1

---

➶

reach

"Therefore, we tested whether theaflavin perturbed the distribution of RelA as assessed by nuclear accumulation."

22111069

Thapsigargin affects MAPK14

| 1

Thapsigargin inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"The effect of UTP on VCAM-1 expression in human coronary artery endothelial cells was prevented by depletion of intracellular calcium stores with thapsigargin or by inhibition of p38 mitogen-activated protein kinase or Rho kinase, but was not affected by inhibitors of the mitogen-activated protein/extracellular signal-regulated kinase pathway (i.e. MEK1/2)."

12714597

Thallium monochloride affects MYD88

| 1

Thallium monochloride inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Some of PP2Ac-target sites (XREF_SUPPLEMENTARY) that were identified based on their phosphorylation increases in TL PP2Ac depleted cells were in the components of TL specific MyD88 interactome (XREF_SUPPLEMENTARY), including Rps6 (a substrate of p70S6K), Rap1 (a MAPK component), Akt1, and a mTORC1/C2 component Raptor, revealing that through sitespecific dephosphorylation constitutively active PP2Ac represses the pro-inflammatory/-apoptotic activity of the PI3K-mTOR-p70S6K-Akt pathway."

23434512

Thallium monochloride affects JUN

| 1

Thallium monochloride inhibits JUN. 1 / 1

| 1

---

➶

sparser

"The second mechanism that downregulates NF-κB is through the inhibition of specificity protein 1 (Sp1) by TL."

28890697

Tetrodotoxin affects RELA

| 1

Tetrodotoxin inhibits RELA. 1 / 1

| 1

---

➶

sparser

"The rela- tively small inhibition by tetrodotoxin on NPY-induced con- traction can perhaps be explained if it is assumed that NPY acts on nerve terminals as well as somatodendrites, since tetrodotoxin inhibits nerve conduction but has no effect at presynaptic nerve terminals to release transmitters (19)."

8332555

Tetrathiomolybdate(2-) affects NLRP3

| 1

Tetrathiomolybdate(2-) inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"A clinically approved copper chelator, tetrathiomolybdate, inhibited the canonical NLRP3 but not the AIM2, NLRC4, and NLRP1 inflammasomes or NF-kappaB-dependent priming."

29358279

Tetraphosphorus affects RELA

| 1

Tetraphosphorus inhibits RELA. 1 / 1

| 1

---

➶

reach

"Moreover, the reversing effect of P4 on nuclear expression of p65 was also partially reversed by pretreatment of progesterone receptor antagonist RU-486, indicating that P4 partially reversing NF-kappaB p65 nuclear translocation stimulated by IL-1beta or TNF-alpha in the synoviocytes was at least partially dependent on progesterone receptor pathway."

29127312

Tetraphosphorus affects JUN

| 1

Tetraphosphorus inhibits JUN. 1 / 1

| 1

---

➶

reach

"Consistent with these observations, we found that the ability of P4 to reduce c-Jun activation was lost upon GR as well as MKP-1 knockdown."

26280733

Tetramethylsilane affects NFKB1

| 1

Tetramethylsilane inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"The mechanism by which TMS inhibits NF-KB activation [5] Takada, A., Ohmori, K., Yoneda, T., Tuyuoka, K., Hasegawa, A., remains unclear."

7540991

Tetramethylpyrazine affects MAPK8

| 1

Tetramethylpyrazine inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"2,3,5,6-tetramethylpyrazine inhibited arsenic-induced activations of JNK, p38 MAPK, ERK, AP-1 and Nrf2 and block HO-1 protein expression."

26404762

Tetradecanoyl group affects IFIH1

| 1

Tetradecanoyl group inhibits IFIH1. 1 / 1

| 1

---

➶

sparser

"Other studies showed that Myr noncompetitively inhibits E. coli DnaB helicase with an IC 50 of approximately 10 μ M [ xref ]; however, we have recently discovered that Gal, Kae, Que, and Myr can inhibit dNTP binding to Kp DnaB, indicating a specific inhibitory process."

23091356

Tetracycline affects NLRP3

| 1

Tetracycline inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"The broad-spectrum tetracycline antibiotic Minocycline also inhibits the NLRP3 inflammasome in several disease models by a mechanism that involves the dampening of ROS generation [XREF_BIBR - XREF_BIBR]."

27942750

Tetracycline affects MAPK14

| 1

Tetracycline inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"In cerebellar granular neurons, the tetracycline abrogates nitric oxide-induced death by inhibiting p38 mitogen-activated protein kinase ( ), and in glia the antibiotic reduces expression of iNOS and caspase-1 ( )."

21286833

Testosterone affects JUN

| 1

Testosterone inhibits JUN. 1 / 1

| 1

---

➶

reach

"Interestingly, inhibition of testosterone induced activation by PD98059 also canceled an upregulation of c-jun and increased apoptosis."

12619033

Testosterone affects FOS

| 1

Testosterone inhibits FOS. 1 / 1

| 1

---

➶

reach

"In the present study, monotherapy with tamsulosin or naftopidil showed inhibitory effects on testosterone induced c-Fos, NGF, and NOS expression depending on the site in the neuronal voiding centers."

29609419

Testosterone affects DDX58

| 1

Testosterone inhibits DDX58. 1 / 1

| 1

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➶

reach

"These results suggested that testosterone or the ratio of testosterone to estrogen may inhibit RIG-I signaling and thereby influence immune responses to HCV infection."

28962219

Teriflunomide affects PYCARD

| 1

Teriflunomide inhibits PYCARD. 1 / 1

| 1

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➶

reach

"Notably, NLRP3 was reduced by IFNb and teriflunomide, while PYCARD and Caspase-1 were only reduced by teriflunomide (results not shown)."

28878732

Teriflunomide affects NLRP3

| 1

Teriflunomide inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Notably, NLRP3 was reduced by IFNb and teriflunomide, while PYCARD and Caspase-1 were only reduced by teriflunomide (results not shown)."

28878732

Teriflunomide affects NFKBIA

| 1

Teriflunomide inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"NF-kappaB pathway inhibition improved response and survival in EGFR-mutant lung cancer patients treated with EGFR TKI (Bivona et al., 2011), our studies found that NFKBIA (NFKB inhibitor alpha) and NFKBIB (NFKB inhibitor beta) were significantly up-regulated by teriflunomide in H460 cells (by ~ 5.08-fold, 1.25-fold, respectively), indicated teriflunomide may involve in the drug resistance of lung cancer treatment.Our studies has some limitations."

29050931

Teriflunomide affects JAK1

| 1

Teriflunomide inhibits JAK1. 1 / 1

| 1

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➶

reach

"12 Furthermore, other proposed mechanisms suggest that teriflunomide inhibits the Janus tyrosine kinase (JAK) enzymes JAK1 and JAK3 13 and reduces transforming growth factor alpha induced nuclear factor kappaB activation."

27766282

Teriflunomide affects CASP1

| 1

Teriflunomide inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Notably, NLRP3 was reduced by IFNb and teriflunomide, while PYCARD and Caspase-1 were only reduced by teriflunomide (results not shown)."

28878732

Terbutaline affects NFKB1

1 |

Terbutaline inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

11675405

Tenoxicam affects ITCH

| 1

Tenoxicam inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Intravenous tenoxicam and rectal diclofenac have been reported to attenuate neuraxial opioid induced itch."

25861787

Telmisartan affects RELA

| 1

Telmisartan inhibits RELA. 1 / 1

| 1

---

➶

reach

"Telmisartan treatment markedly reduced Abeta42, APP, BACE1, RAGE, and NF-kappaB p65 of the hippocampus and cortex, but did not beneficially affect hyperglycemia and hypoinsulinemia in the STZ induced diabetic mice compared with untreated diabetic mice."

24671053

Telmisartan affects JUN

| 1

Telmisartan inhibits JUN. 1 / 1

| 1

---

➶

reach

"Telmisartan decreases interleukin-1beta-induced c-Jun N-terminal kinase and c-Jun activation."

22642771

Tellurium atom affects CASP1

1 |

Tellurium atom inhibits CASP1. 1 / 1

1 |

---

➶

ctd

No evidence text available

18571097

Technetium atom affects MYD88

| 1

Technetium atom inhibits MYD88. 1 / 1

| 1

---

➶

reach

"The key molecules in the downstream signaling cascades of TLR4, including myeloid differentiation factor (MyD) 88, nuclear factor (NF)-kappaB, IL-1beta, Toll-IL-1 receptor domain containing adaptor inducing interferon-beta (TRIF), TRIF related adaptor molecule (TRAM), interferon regulatory factor (IRF) -3 and IFN-beta, all decreased significantly in TC groups, suggesting that TC inhibits both MyD88 dependent and -independent pathways of TLR4."

23340441

Tebufenozide affects RELA

| 1

Tebufenozide inhibits RELA. 1 / 1

| 1

---

➶

reach

"However, at the12 h exposure, the p65 was inhibited by both tebufenozide (60% inhibition) and methoxyfenozide (40% inhibition) treatments when compared to control."

12878229

Taurine affects MAPK8

| 1

Taurine inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"Taurine co-infusion with IH prevented the rise in 8-isoprostaglandin and MDA, inhibited the activation of JNK1, and improved insulin signaling and insulin resistance in liver."

20855122

Tannic acid affects NFKBIA

| 1

Tannic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

medscan

"As predicted from our initial cellular data, tannic acid inhibits and impairs the rate of sumoylation of other substrates, including recombinant hinge-LBD SF-1, full-length IκBα, and an androgen peptide ( )."

26653140

Tannic acid affects MAPK14

| 1

Tannic acid inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Tannic acid significantly inhibited the activation of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinases."

16842597

Tanespimycin affects MAVS

| 1

Tanespimycin inhibits MAVS. 1 / 1

| 1

---

➶

reach

"Taken together, these results suggest that geldanamycin and 17-AAG inhibit IRF3 activation by preventing MAVS aggregation on the mitochondria."

21782231

Tanespimycin affects CHUK

| 1

Tanespimycin inhibits CHUK. 1 / 1

| 1

---

➶

reach

"17-AAG decreased IKK complex proteins, IKKalpha and IKKbeta."

18034886

Tamoxifen affects NFKBIA

| 1

Tamoxifen inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"IkappaBalpha strongly inhibited proliferation of co-cultured MCF-7 treated with TNF-alpha, tamoxifen, or ICI 182,780 (XREF_FIG a, right panel, arrows)."

30736340

Tamoxifen affects JAK1

| 1

Tamoxifen inhibits JAK1. 1 / 1

| 1

---

➶

sparser

"ICI 182 780 and tamoxifen also inhibited the IFN-γ-induced tyrosine phosphorylation of STAT1α, Jak1, and Jak2, whereas progesterone, DHT, or testosterone had no effects (data not shown)."

12603854

Tamoxifen affects IKBKB

| 1

Tamoxifen inhibits IKBKB. 1 / 1

| 1

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➶

reach

"IKKbeta-AKO mice with tamoxifen induced IKKbeta deletion prior to HFD exposure showed equivalent HFD induced weight gain and glucose intolerance as Ikbkb fl/fl littermate controls."

28377875

Tamoxifen affects FOS

| 1

Tamoxifen inhibits FOS. 1 / 1

| 1

---

➶

reach

"CGP 41251 and tamoxifen selectively inhibit mitogen activated protein kinase activation and c-Fos phosphoprotein induction by substance P in human astrocytoma cells."

9372245

Tamoxifen affects CHUK

| 1

Tamoxifen inhibits CHUK. 1 / 1

| 1

---

➶

sparser

"Since thehCD20Tam Cre inducible system does not account for the contribution of p100 cleavage that occurred before tamoxifen-induced Ikk1 inactivation, we intercrossedIkk1 L/L mice with Cd19 Cre mice to eliminate IKK1 prior to the onset of BAFF-R expression."

24239354

Tacrolimus (anhydrous) affects ITCH

| 1

Tacrolimus (anhydrous) inhibits ITCH. 1 / 1

| 1

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➶

reach

"XREF_BIBR, XREF_BIBR While TCIs are well tolerated and superior to vehicle alone in preventing relapse of AD, a recent meta-analysis suggested that topical tacrolimus may not be as efficacious as topical fluticasone propionate to prevent flares of AD and pruritus."

21767774

Swainsonine affects FOS

| 1

Swainsonine inhibits FOS. 1 / 1

| 1

---

➶

reach

"Additionally, a microinfusion of swainsonine blocked c-fos induction in the hippocampus, which is observed when memory is consolidated."

27343988

Superoxide affects NFKB1

| 1

Superoxide inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"The ROS scavengers N-acetyl cysteine (NAC) and superoxide dismutase (SOD) mimetic MnTBAP inhibited LPS induced accumulation of nuclear RelB and p50, but had no effects on nuclear RelA, c-Rel and p52 (XREF_FIG and XREF_SUPPLEMENTARY)."

25367573

Superoxide affects ITCH

| 1

Superoxide inhibits ITCH. 1 / 1

| 1

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➶

reach

"The reactive oxygen species scavengers N-acetylcysteine (NAC; 204 mg/kg i.p.; 86%) or superoxide dismutase (SOD; 10 mg/kg i.p.; 83%) also inhibited itch."

23271050

Superoxide affects IFNB1

| 1

Superoxide inhibits IFNB1. 1 / 1

| 1

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➶

reach

"Scavenging of superoxide decreases TNF-alpha and IFN-beta synthesis in poly (I : C)-stimulated NOD BM-Mphi."

22361747

Sunitinib affects TLR7

| 1

Sunitinib inhibits TLR7. 1 / 1

| 1

---

➶

reach

"Similar results were obtained in BMDCs, in that SZU-101, rather than the TKIs, elevated the TLR7 expression, whereas sunitinib still degraded SZU-101-induced TLR7."

28000738

Sunitinib affects RELA

| 1

Sunitinib inhibits RELA. 1 / 1

| 1

---

➶

reach

"In these conditions, sunitinib further inhibited AKT and also the activation of p65 and IkappaBalpha induced by radiotherapy."

31912683

Sunitinib affects NFKBIA

| 1

Sunitinib inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"In these conditions, sunitinib further inhibited AKT and also the activation of p65 and IkappaBalpha induced by radiotherapy."

31912683

Sumatriptan affects FOS

| 1

Sumatriptan inhibits FOS. 1 / 1

| 1

---

➶

reach

"The 5-hydroxytryptamine (1B/1D/1F) receptor agonist sumatriptan (0.01, 0.1, 1 and 10 mg/kg), administered intraperitoneally 15 min before capsaicin stimulation (1 nmol), decreased the c-fos response within Sp5C, but not within solitary tract."

12110114

Sulindac affects NFKB1

1 |

Sulindac inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

18922898

Sulindac affects CHUK

| 1

Sulindac inhibits CHUK. 1 / 1

| 1

---

➶

reach

"Moreover, sulindac was reported to inhibit in vitro IKKbeta, but not IKKalpha, protein kinase activity, suggesting that it might be possible to find isoform specific inhibitors of IKK."

12110242

Sulindac sulfide affects NFKBIA

| 1

Sulindac sulfide inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"In order to determine if this activation was transient or sustained, we studied the kinetics of IkappaBalpha degradation in cells treated with 50muM sulindac sulfide for 0.5, 1, 2, 4 and 16hours."

24083678

Sulindac sulfide affects NFKB1

1 |

Sulindac sulfide inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

12085227

Sulindac sulfide affects IKBKB

1 |

Sulindac sulfide inhibits IKBKB. 1 / 1

1 |

---

➶

ctd

No evidence text available

11912124

Sulfur dioxide affects RELA

| 1

Sulfur dioxide inhibits RELA. 1 / 1

| 1

---

➶

reach

"Sulphur dioxide suppresses inflammatory response by sulphenylating NF-kappaB p65 at Cys"

28935810

Sulforaphane affects STING1

| 1

Sulforaphane inhibits STING1. 1 / 1

| 1

---

➶

reach

"4-OI and SFN repress STING and IFN in SAVI fibroblasts."

30158636

Sulforaphane affects STAT1

| 1

Sulforaphane inhibits STAT1. 1 / 1

| 1

---

➶

reach

"SFN inhibited IFN-gamma and TNF-alpha-induced NF-kappaB activation as well as STAT1 activation."

21116791

Sulforaphane affects MAPK14

| 1

Sulforaphane inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells."

16951197

Sulforaphane affects IFNB1

| 1

Sulforaphane inhibits IFNB1. 1 / 1

| 1

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➶

reach

"Using a high-throughput qPCR approach, we assessed the levels of IFN stimulated genes (ISGs), including Ccl5, Cxcl10, Tmem173, Ddx58, and Irf7, which were all highly induced by VSV infection, whereas SFN treatment inhibited ISG expression; VSVDelta51 induced Ifnb1 and Il-29 mRNA were drastically inhibited by SFN by more than 50 and 500 times, respectively (XREF_FIG B)."

28527723

Sulforaphane affects FOS

| 1

Sulforaphane inhibits FOS. 1 / 1

| 1

---

➶

sparser

"In addition, our data clearly indicate that SFN inhibits cFos from binding to the MMP-1 TRE after UVB exposure."

19671797

Sulforaphane affects EIF2AK1

| 1

Sulforaphane inhibits EIF2AK1. 1 / 1

| 1

---

➶

reach

"In order to examine whether HRI is required for the translation of HO-1 mRNA, HRI in HEK cells was knocked down with HRI siRNA, and cells were then treated with sulforaphane."

28347842

Sulfonylureas affects NLRP3

| 1

Sulfonylureas inhibits NLRP3. 1 / 1

| 1

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➶

reach

"We report the synthesis and biological evaluation of nine sulfonylureas that inhibit NLRP3 activation in murine bone-marrow- derived macrophages in a potent, dose dependent manner."

28703484

Sulfonyldimethane affects NLRP3

| 1

Sulfonyldimethane inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Methylsulfonylmethane inhibits NLRP3 inflammasome activation."

25461402

Sulfometuron methyl affects RELA

| 1

Sulfometuron methyl inhibits mutated RELA. 1 / 1

| 1

---

➶

reach

"A relA mutant of S. typhimurium was inhibited by sulfometuron methyl on rich carbon sources that display a basal cyclic AMP level but not on poor carbon sources where the cyclic AMP concentration is elevated."

6090425

Sulfite affects RELA

| 1

Sulfite inhibits RELA. 1 / 1

| 1

---

➶

reach

"Moreover, andrographolide sulfonate markedly suppressed the activation of p38 mitogen activated protein kinase as well as p65 subunit of nuclear factor-kappaB (NF-kappaB)."

24704625

Sulfate affects TANK

| 1

Sulfate inhibits TANK. 1 / 1

| 1

---

➶

reach

"A laboratory-scale two-phase treatment system composed of a sulfate reducing (SR) tank and multi staged up-flow anaerobic sludge blanket (MS-UASB) reactor was used as the pre-treatment unit."

24647181

Sulfate affects NLRP3

| 1

Sulfate inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"It also ameliorates dextran sulfate sodium induced colitis in caspase-1 -/- mice by inhibiting the activation of NLRP3 inflammasomes and the subsequent secretion of IL-1beta."

29491837

Sulfate affects IFNB1

| 1

Sulfate inhibits IFNB1. 1 / 1

| 1

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➶

reach

"This paper demonstrates that the sulfide concentration needs to be controlled in sulfate reducing IFB reactors to steer the location of the metal precipitates for recovery."

21664045

Sulfate affects FOS

| 1

Sulfate inhibits FOS. 1 / 1

| 1

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➶

reach

"Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice."

26136670

Sulfapyridine affects CHUK

| 1

Sulfapyridine inhibits CHUK. 1 / 1

| 1

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➶

reach

"Sulfapyridine and propranolol appeared to inhibit NIK and IKKalpha, 2 essential kinases in the non canonical pathway, while having no effect on IKKbeta, a key mediator of the canonical pathway."

29374256

Succinic acid affects NLRP3

| 1

Succinic acid inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"C-AR inhibited succinate mediated NLRP3 inflammasome activation by attenuating synovial hypoxia and HIF-1alpha induction, and thereby prevented fibroblast activation in CIA."

28003810

Strontium(2+) affects STING1

| 1

Strontium(2+) inhibits STING1. 1 / 1

| 1

---

➶

reach

"In an attempt to discover new classes of anti-irritant compounds without anesthetic properties, I observed that topical application of strontium salts to intact skin produced potent suppression of sting, burn, and itch caused by many irritant chemicals."

10491058

Streptozocin affects RELA

1 |

Streptozocin inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

19002579

Streptozocin affects NLRP3

| 1

Streptozocin inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Methods : Vascular reactivity, reactive oxygen species (ROS) generation, calcium (Ca 2+) influx and caspase-1 and IL-1beta activation were determined in mesenteric resistance arteries from normoglicemic and streptozotocin induced diabetic C57BL/6 and NLRP3 knockout (Nlrp3 -/-) mice."

32009974

Streptozocin affects NFKB1

1 |

Streptozocin inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

19166939

Streptomycin affects FOS

| 1

Streptomycin inhibits FOS. 1 / 1

| 1

---

➶

eidos

"SM significantly reduced DRG neuron hyperexcitability , c-Fos and PKCgamma expression , as well as IL-1beta in DRG neurons ."

32457570

Steroid affects JUN

| 1

Steroid inhibits JUN. 1 / 1

| 1

---

➶

sparser

"Steroids inhibit the transcription factors activator protein-1 and nuclear factor kappa-B, which both have important roles in the production of cytokines including IL-1 and IL-2, GM-CSF, TNF-alpha, growth factors, gamma interferon, CD40 ligand, and others [ xref , xref ]."

22548034

Steroid affects FOS

| 1

Steroid inhibits FOS. 1 / 1

| 1

---

➶

sparser

"Mitogen-stimulated MAP-kinase kinase and MAP-K activities were significantly inhibited by either E or P. The steroids also inhibited mitogen-stimulated c-fos and c-myc, downstream targets for MAP-K action."

9231785

Sterculic acid affects NFKBIA

| 1

Sterculic acid inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Sterculic acid did not antagonize the TNF-alpha-mediated inductions of IL-1beta, IL-8, or IkappaBalpha."

22342272

Stavudine affects NLRP3

| 1

Stavudine inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-beta Autophagy."

31594217

Staurosporine affects STAT1

| 1

Staurosporine inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Treatment of staurosporine, a kinase inhibitor, abolished the prolonged activation of Stat1 caused by the proteasome inhibitor."

10354707

Staurosporine affects NFKB1

| 1

Staurosporine inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Staurosporine stimulation failed to induce the detectable degradation of IkappaB-alpha, IkappaB-beta, or p105 (IkappaB-gamma) within the time frame of the observed NF-kappaB activation."

9698090

Staurosporine affects MYD88

| 1

Staurosporine inhibits MYD88. 1 / 1

| 1

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➶

reach

"Staurosporine, a selective PKC inhibitor, inhibited TLR4, MyD88 and p-p38 upregulation in the high-glucose-treated cells, indicating the involvement of PKC in high-glucose-induced TLR4 upregulation."

28542370

Staurosporine affects IRF9

| 1

Staurosporine inhibits IRF9. 1 / 1

| 1

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➶

reach

"Activation of ISGF3 alpha, although insensitive to 2-aminopurine, was completely blocked by 10 nM staurosporine, an inhibitor of protein kinase C. On the other hand, even 500 nM staurosporine did not block the induction of ISGF3 gamma."

1556141

Staurosporine affects IRF3

| 1

Staurosporine inhibits IRF3. 1 / 1

| 1

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➶

reach

"Staurosporine and TPCK but not TLCK blocked the activation of IRF-3 induced by LPS or poly (I : C)."

12062447

Stattic affects MAP3K7

| 1

Stattic inhibits MAP3K7. 1 / 1

| 1

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➶

reach

"The addition of STAT3 inhibitor Stattic, but not RIP1K inhibitor Nec-1, significantly reduced cytoplasmic detection of both STAT3 and TAK1 in infected cells (XREF_FIG)."

25419841

Stattic affects JUN

| 1

Stattic inhibits JUN. 1 / 1

| 1

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➶

reach

"Stattic has been shown to specifically inhibit STAT3 over STAT1, STAT5, c-Myc and Max, Jun and Jun and Lck in HepG2 cell lines XREF_BIBR."

24945434

Squaric acid dibutyl ester affects ITCH

| 1

Squaric acid dibutyl ester inhibits ITCH. 1 / 1

| 1

---

➶

reach

"The SADBE- but not the acetone treated skin resulted in 1) localized inflammation, with spontaneous itch and nociceptive sensations peaking at 24 to 48hours after challenge, 2) alloknesis, hyperknesis, and hyperalgesia to mechanical stimuli that were reduced or eliminated by anesthetic cooling of the SADBE treated area and restored on rewarming, suggesting that sensations and dysesthesias are dependent on ongoing peripheral neural activity, and 3) enhanced itch to intradermal injection of histamine, BAM8-22, or beta-alanine."

26002605

Sphingosine-1-phosphocholine affects IKBKB

| 1

Sphingosine-1-phosphocholine inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Celgene has developed a series of quinazoline analogues including a molecule termed SPC 839, which inhibits IKKbeta with an IC50 of 62 nM and has been shown to reduce paw oedema in a rat arthritis model [78]."

18308615

Sphingosine 1-phosphate affects MAPK8

| 1

Sphingosine 1-phosphate inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"It was concluded that sphingosine-1-phosphate down-regulates the ATPase by inhibiting both JNK and NF-κB."

22271589

Spermidine affects STAT1

| 1

Spermidine inhibits STAT1. 1 / 1

| 1

---

➶

medscan

"We have demonstrated that spermidine treatment markedly reduces IFN-γ-induced phosphorylation of STAT1, which leads to reduced secretion of the cytokine MCP-1 in a PTPN2-dependent manner."

24040033

Spermidine affects RELA

| 1

Spermidine inhibits RELA. 1 / 1

| 1

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➶

reach

"As shown in XREF_FIG, the immunoblotting data using cytoplasmic and nuclear extracts indicated that spermidine pretreatment inhibited NF-kappaB p65 subunit nuclear accumulation, which was associated with the attenuation of IkappaBalpha degradation in LPS stimulated RAW 264.7 cells (XREF_FIG)."

28365977

Spermidine affects JUN

| 1

Spermidine inhibits JUN. 1 / 1

| 1

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➶

reach

"Finally, the depletion of polyamines, particularly spermidine, by DL-alpha-difluoromethylornithine treatment also prevents c-jun induction by insulin but DL-alpha-difluoromethylornithine treatment has no effect on c-jun induction by vanadate."

1330658

Soyasaponin I affects TRAF6

| 1

Soyasaponin I inhibits TRAF6. 1 / 1

| 1

---

➶

reach

"In LPS stimulated macrophages, soyasaponins A 2 or I significantly decreased MyD88 (p < 0.05), soyasaponins A 1, A 2 or I reduced p-IRAK-4 and p-IRAK-1 (p < 0.05), and soyasaponin I decreased TRAF6 (p < 0.05)."

32493316

Sotrastaurin affects TBK1

| 1

Sotrastaurin inhibits TBK1. 1 / 1

| 1

---

➶

reach

"In agreement with these findings, PKCtheta was activated by EGF, insulin, and FBS, and the PKC inhibitor Sotrastaurin impaired the activation of PKCtheta and TBK1 (XREF_FIG and XREF_FIG, XREF_FIG)."

31792381

Sorafenib affects TRAF3

| 1

Sorafenib inhibits TRAF3. 1 / 1

| 1

---

➶

reach

"In vitro, sorafenib inhibited b-Raf and Raf-1 (c-Raf or c-Raf-1), pro angiogenic vascular endothelial growth factor receptor, and platelet derived growth factor receptor (Wilhelm and Chien, 2002)."

18040273

Sorafenib affects STAT1

| 1

Sorafenib inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Moreover, sorafenib inhibited IFN-alpha induced oncogenic signaling of STAT3, AKT and ERK but not the activation of the tumor suppressor STAT1."

22634008

Sorafenib affects MAPK8

| 1

Sorafenib inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"In HuH-7 cells, metformin and sorafenib effectively inhibited various species of MEK1/2, ERK1/2, JNK1 and AKT1."

27326258

Sorafenib affects FOS

| 1

Sorafenib inhibits FOS. 1 / 1

| 1

---

➶

reach

"Therefore, down-regulation of c-Fos by sorafenib is an important finding as c-Fos acts as a significant therapeutic and prognostic biomarker."

29744300

Sonidegib affects RELA

| 1

Sonidegib inhibits RELA. 1 / 1

| 1

---

➶

reach

"Correspondingly, a decrease in expression of pAKT and nuclear p65 was seen in cells treated with LDE225."

27105509

Sodium(1+) affects TBK1

| 1

Sodium(1+) inhibits TBK1. 1 / 1

| 1

---

➶

reach

"Other studies report that exposure to DI causes rapid fluid and sodium loss, which increases the Na/K ratio in urine."

30971938

Sodium(1+) affects STAT1

| 1

Sodium(1+) inhibits STAT1. 1 / 1

| 1

---

➶

reach

"[Sodium Aescinate Induced Apoptosis of BGC-823 and AGS Cells by Inhibiting JAK-1 and STAT-1 Signaling Pathway]."

30209928

Sodium(1+) affects PYCARD

| 1

Sodium(1+) inhibits PYCARD. 1 / 1

| 1

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➶

reach

"Drug influx by system L was determined in sodium-poor medium, in which transport by the sodium dependent system ASC is inhibited [18, 20-22]."

3977953

Sodium(1+) affects NFKBIA

| 1

Sodium(1+) inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"We have shown in rats that sodium salicylate (SS), which inhibits IkBa kinase B (IKKB), prevents hepatic and peripheral insulin resistance caused by short-term (7h) i.v. administration of Intralipid and heparin (IH)."

23328071

Sodium(1+) affects JAK1

| 1

Sodium(1+) inhibits JAK1. 1 / 1

| 1

---

➶

reach

"[Sodium Aescinate Induced Apoptosis of BGC-823 and AGS Cells by Inhibiting JAK-1 and STAT-1 Signaling Pathway]."

30209928

Sodium(1+) affects IFNB1

| 1

Sodium(1+) inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Ye et al. showed bufalin and other cardiac glycoside inhibitors of the sodium pump block the activation of the transcription factors IRF3 and NF-kappaB by inhibiting the induction of interferon-beta."

24734105

Sodium hypochlorite affects NFKBIA

| 1

Sodium hypochlorite inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"CONCLUSIONS; NaOCl oxidizes IkappaBalpha at methionine residues and thereby suppresses dissociation of IkappaBalpha from NFkappaB."

12356823

Sodium hydrogencarbonate affects STING1

| 1

Sodium hydrogencarbonate inhibits STING1. 1 / 1

| 1

---

➶

reach

"Warming of injectable solutions, use of sodium bicarbonate to reduce the sting of the acid solution, using an appropriate bore needle, and constant reassurance are all small but significant measures to make the task easier and less painful."

22279267

Sodium chloride affects RELA

| 1

Sodium chloride inhibits RELA. 1 / 1

| 1

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➶

reach

"The relA mediated temperature sensitivity was osmoremedial and could be completely suppressed, for example, by the addition of NaCl to the medium at a concentration of 0.3 M."

13129947

Sodium atom affects TRAF6

| 1

Sodium atom inhibits TRAF6. 1 / 1

| 1

---

➶

reach

"The protein levels of TRAF2 and TRAF6 were reduced in cancer cell lines treated with NA, but not TRAF3, TRADD, and FADD."

25575821

Sodium atom affects ITCH

| 1

Sodium atom inhibits ITCH. 1 / 1

| 1

---

➶

sparser

"Nedocromil sodium inhibits histamine-induced itch and flare in human skin."

11159712

Sodium atom affects FOS

| 1

Sodium atom inhibits FOS. 1 / 1

| 1

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➶

reach

"Application of the Na + channel blocker TTX during stimulation blocked c-Fos induction, indicating that spiking activity was necessary to trigger the signaling cascade leading to c-Fos expression (XREF_FIG)."

19997631

Sodium arsenite affects NFKB1

1 |

Sodium arsenite inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

15028728

Sodium arsenite affects JAK1

1 |

Sodium arsenite inhibits JAK1. 1 / 1

1 |

---

➶

ctd

No evidence text available

15116095

Sodium 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate affects NLRP3

| 1

Sodium 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"SSR could contribute to renal protection by inhibiting the activation of NLRP3 inflammasome and, furthermore, strengthen the antifibrotic effects by up-regulating Sirt1 and Smad3 deacetylation pathway in 5/6 renal (A/I) model."

31118021

Sitosterol affects STAT2

| 1

Sitosterol inhibits STAT2. 1 / 1

| 1

---

➶

reach

"XREF_FIG, supernatants from infected A549 cells stimulated the phosphorylation of STAT1 Tyr701 and STAT2 Tyr690, while supernatants from donor cells treated with beta-sitosterol attenuated the phosphorylation of STAT1 Tyr701."

| PMC

Sitosterol affects STAT1

| 1

Sitosterol inhibits STAT1. 1 / 1

| 1

---

➶

reach

"XREF_FIG, supernatants from infected A549 cells stimulated the phosphorylation of STAT1 Tyr701 and STAT2 Tyr690, while supernatants from donor cells treated with beta-sitosterol attenuated the phosphorylation of STAT1 Tyr701."

| PMC

Sitagliptin affects NLRP3

| 1

Sitagliptin inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"18 Interestingly, some studies found that sitagliptin also inhibited the NLRP3 inflammasome 23 via an identical mechanism to that used by irisin to inhibit inflammatory cytokines."

32364035

Sitagliptin affects FOS

| 1

Sitagliptin inhibits FOS. 1 / 1

| 1

---

➶

reach

"In addition, sitagliptin significantly reduced the expression of osteoclast specific markers in mouse bone-marrow-derived macrophages, including calcitonin receptor (Calcr), dendrite cell specific transmembrane protein (Dc-stamp), c-Fos, and nuclear factor of activated T-cells cytoplasmic 1 (Nfatc1)."

28713268

Sitagliptin affects CHUK

| 1

Sitagliptin inhibits CHUK. 1 / 1

| 1

---

➶

reach

"However, sitagliptin pretreatment significantly reduced the p-IKKalpha at both doses compared to MTX group (XREF_FIG)."

28334048

Sirolimus affects OAS2

| 1

Sirolimus inhibits OAS2. 1 / 1

| 1

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➶

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"As shown in XREF_FIG, both anti--IFNAR2 antibody and rapamycin inhibited IFNbeta induction of OAS2 RNA; inhibition by anti--IFNAR2 was rapid (within 24 h), while inhibition by rapamycin was only evident at 72 hr."

28107341

Sirolimus affects NFKBIA

1 |

Sirolimus inhibits NFKBIA. 1 / 1

1 |

---

➶

ctd

No evidence text available

22363816

Sirolimus affects NFKB1

| 1

Sirolimus inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Rapamycin inhibited the synthesis and accumulation of both p50 and p70 as well as inhibiting ecdysteroidogenesis."

7787842

Sirolimus affects JUN

| 1

Sirolimus inhibits JUN. 1 / 1

| 1

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➶

reach

"Rapamycin inhibits activator protein-1 but not nuclear factor-kappaB activity of mature bone marrow derived dendritic cells."

20620542

Sirolimus affects IRF7

| 1

Sirolimus inhibits IRF7. 1 / 1

| 1

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➶

reach

"FTS, rapamycin and re-expression of TSC2 inhibit the IRF7 transcription factor."

25476905

Sincalide affects TRAF6

| 1

Sincalide inhibits TRAF6. 1 / 1

| 1

---

➶

medscan

"CCK8 inhibited TLR9-induced activation of tumor-necrosis factor receptor-associated factor 6, which is an important adapter protein in activation of interferon-regulatory factor 5 and IRF7, possibly through CCK2R, by evoking the activity of protein kinase A and reducing the activity of PKC."

24301797

Simvastatin affects NFKBIA

| 1

Simvastatin inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Further study indicated that simvastatin significantly attenuated NF-kappaB activity by inhibiting the degradation of IkappaB-alpha."

32288932

Simvastatin affects NFKB1

1 |

Simvastatin inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

17038636

Simvastatin affects MAP3K7

1 |

Simvastatin inhibits MAP3K7. 1 / 1

1 |

---

➶

ctd

No evidence text available

17277159

Simvastatin affects JUN

| 1

Simvastatin inhibits JUN. 1 / 1

| 1

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➶

reach

"Longitudinal transcriptional profiling revealed that simvastatin downregulated the inflammatory genes fos, jun, and tumor necrosis factor-alpha and upregulated the cell cycle inhibitor p27Kip1, endothelial nitric oxide synthase, and bone morphogenetic protein receptor type 1a."

12963647

Simvastatin affects IRF3

| 1

Simvastatin inhibits IRF3. 1 / 1

| 1

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➶

reach

"Independent of mevalonate and NF-kappaB, previously acknowledged anti-inflammatory mechanisms of pleiotropic statins, simvastatin selectively inhibited dsRNA induced IRF3 activation and production of TSLP and IFN-beta in COPD epithelium."

22881993

Silver(1+) affects TANK

| 1

Silver(1+) inhibits TANK. 1 / 1

| 1

---

➶

reach

"Levitation with Ag (+) dramatically decreased the survival of MRSA floating in a water tank."

24304000

Silver(1+) affects RELA

| 1

Silver(1+) inhibits RELA. 1 / 1

| 1

---

➶

reach

"Furthermore, AGN, but not D/DA, suppressed Rela (NF-kappaB related)."

26116406

Silver(1+) affects NLRP3

| 1

Silver(1+) inhibits NLRP3. 1 / 1

| 1

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➶

reach

"In vivo, administration of Ag in the form of an immune complex during priming of the immune response inhibited resultant adaptive immune responses in an NLRP3 dependent model of allergic airway disease."

25320279

Silver(1+) affects NFKB1

| 1

Silver(1+) inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Regarding the inhibitory mechanism of AG, it has been demonstrated that AG binds to reduced cysteine 62 of the NF-kappaB p50 subunit following thiolation, and AG fails to inhibit binding of p50 in a C62S mutant [XREF_BIBR]."

23840248

Silver(1+) affects JUN

| 1

Silver(1+) inhibits JUN. 1 / 1

| 1

---

➶

reach

"In addition, AG inhibited the production of interleukin (IL)-6, IL-8, and TNF-alpha, as well as the activation of Jun N-terminal kinase and nuclear factor-kappaB in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 stimulated human mast cells."

22705330

Silver(1+) affects IKBKE

| 1

Silver(1+) inhibits IKBKE. 1 / 1

| 1

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➶

reach

"Therefore, while our data strongly suggest that AG has dual independent inhibitory targets (ERK and IKKepsilon) in TLR activated inflammatory signaling, further studies are needed to determine how AG can simultaneously inhibit two different enzymes, namely, ERK and IKKepsilon."

23840248

Silver(1+) affects IFNB1

| 1

Silver(1+) inhibits IFNB1. 1 / 1

| 1

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➶

reach

"Because late phase activation of JAK2 is known to be autologously activated by type I interferons such as IFN-beta, we examined whether AG suppresses IFN-beta production."

23840248

Silicon monoxide affects TANK

| 1

Silicon monoxide inhibits TANK. 1 / 1

| 1

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➶

reach

"Moreover, silica, especially 15-nm SiO 2 -NPs, decreased the degree of locomotive activity and the normal kinetic pattern of the zebrafish in the CPP tank, resulting in behaviours similar to those observed in neurodegenerative diseases."

24448416

Silicon dioxide affects TANK

| 1

Silicon dioxide inhibits TANK. 1 / 1

| 1

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➶

reach

"Moreover, silica, especially 15-nm SiO 2 -NPs, decreased the degree of locomotive activity and the normal kinetic pattern of the zebrafish in the CPP tank, resulting in behaviours similar to those observed in neurodegenerative diseases."

24448416

Silicon dioxide affects STING1

| 1

Silicon dioxide inhibits STING1. 1 / 1

| 1

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➶

reach

"Degradation of extracellular self-dsDNA by DNase I inhibits silica induced STING activation and the downstream type I IFN response."

30523277

Silicon dioxide affects NLRP3

| 1

Silicon dioxide inhibits NLRP3. 1 / 1

| 1

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➶

reach

"In these studies, inhibiting actin polymerization via cytochalasin leads to the inhibition of silica induced activation of the NLRP3 inflammasome."

27650313

Silicon dioxide affects CASP1

| 1

Silicon dioxide inhibits CASP1. 1 / 1

| 1

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➶

reach

"Crystalline silica induced caspase-1 enzymatic activity and inflammasome readouts are attenuated by thioredoxin."

25406505

Silibinin affects STAT1

| 1

Silibinin inhibits STAT1. 1 / 1

| 1

---

➶

medscan

"However, treatment with silibinin lowered the level of phosphorylated STAT1 in IFN-γ-activated cells ( )."

25032222

Silibinin affects NFKB1

| 1

Silibinin inhibits NFKB1. 1 / 1

| 1

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➶

reach

"More importantly, in an ectopic allograft model, oral administration of silibinin and DHS (200 mg/kg body weight) strongly inhibited the ASZ tumor growth by 44 and 71% (p < 0.05), respectively, and decreased the expression of proliferation biomarkers (PCNA and cyclin D1) as well as NF-kappaB p50 and c-Fos in the tumor tissues."

25492239

Silibinin affects MAPK8

| 1

Silibinin inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"In other study, silibinin caused strong inhibition of Jnk1/2 activation in LNCaP cells while in DU145 cells, a strong induction in Jnk1/2 activation was observed."

18253818

Silibinin affects JUN

| 1

Silibinin inhibits JUN. 1 / 1

| 1

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➶

reach

"Consistent with its effects on COX2 and iNOS, similar silibinin treatments also inhibited UVB caused NF-kappaB and STAT3 activation in both skin and skin tumors [XREF_BIBR]; silibinin also strongly inhibited the activation of transcription factor AP-1 [XREF_BIBR]."

26097804

Silibinin affects FOS

| 1

Silibinin inhibits FOS. 1 / 1

| 1

---

➶

reach

"More importantly, in an ectopic allograft model, oral administration of silibinin and DHS (200 mg/kg body weight) strongly inhibited the ASZ tumor growth by 44 and 71% (p < 0.05), respectively, and decreased the expression of proliferation biomarkers (PCNA and cyclin D1) as well as NF-kappaB p50 and c-Fos in the tumor tissues."

25492239

Sepiapterin affects IKBKB

| 1

Sepiapterin inhibits IKBKB. 1 / 1

| 1

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➶

reach

"Enhancement of the endothelial nitric oxide synthase (eNOS)/NO pathway combined with sepiapterin and simultaneous inhibition of IKK-beta represents a potential countermeasure approach for radiation induced cardiovascular diseases (M. Natarajan)."

27387859

Selumetinib affects RELA

| 1

Selumetinib inhibits phosphorylated RELA. 1 / 1

| 1

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➶

reach

"In contrast phosphorylated Rel-A was not detected in BT-40 xenografts and was significantly reduced by selumetinib treatment in BT-40 and REV tumors relative to the levels detected in BT-40 and AZD tumors, XREF_FIG."

24132923

Selumetinib affects CASP1

| 1

Selumetinib inhibits CASP1. 1 / 1

| 1

---

➶

reach

"In addition, AZD6244 inhibited acrolein induced increases in activated caspase 1 (a biomarker of inflammasome activation) and heme oxygenase-1 (a redox regulated chaperone protein) in BV-2 cells."

31786775

Selenomethionine affects JUN

| 1

Selenomethionine inhibits JUN. 1 / 1

| 1

---

➶

reach

"At micromolar concentrations, ebselen, selenomethionine, and selenocysteine effectively prevented nuclear accumulation of activator protein-1 (AP-1) and nuclear factor kappaB (NF-kappaB) evoked by exogenous ONOO (-), in both polymorphonuclear and mononuclear leukocytes, and inhibited IL-8 gene and protein expression."

14572605

Selenium atom affects TICAM1

| 1

Selenium atom inhibits TICAM1. 1 / 1

| 1

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➶

reach

"Also, selenium, and stilbenoids including resveratrol and pinosylvin, have been reported to inhibit not only the NF-kappaB pathway but also the TRIF dependent pathway [XREF_BIBR - XREF_BIBR]."

22816309

Selenium atom affects STING1

| 1

Selenium atom inhibits STING1. 1 / 1

| 1

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➶

reach

"In addition, selenium supplementation inactivated the Sting pathway."

32737811

Selenium atom affects NFKB1

| 1

Selenium atom inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Firstly, selenium supplementation of T-lymphocytic ACH-2 cells can increase glutathione peroxidase activity and decrease NF-KB activation induced by H ^ O ^, TNFa or PMA [45]."

9037247

Selenium atom affects IRF3

| 1

Selenium atom inhibits IRF3. 1 / 1

| 1

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➶

reach

"Selenium suppresses the activation of transcription factor NF-kappa B and IRF3 induced by TLR3 or TLR4 agonists."

18279804

Selenium atom affects IFNB1

| 1

Selenium atom inhibits IFNB1. 1 / 1

| 1

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➶

reach

"LPS increased (P < 0.05) mRNA profiles of 9 inflammation related genes in cells, while short-time Se pretreatment modestly reversed (P < 0.05) the LPS induced upregulation of 7 genes (COX-2, ICAM-1, IL-1beta, IL-6, IL-10, iNOS, and MCP-1) and further increased (P < 0.05) expression of IFN-beta and TNF-alpha in stressed cells."

29671252

Selenite(2-) affects NFKB1

| 1

Selenite(2-) inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"By the same token, the dose and form of Se we chose may also explain why SeMet did not have a significant effect on phosphorylation of NFkB p65 while high doses of selenite have been shown to inhibit NFkB activity in cells other than chondrocytes, such as macrophages [XREF_BIBR, XREF_BIBR - XREF_BIBR]."

21035557

Seaborgium atom affects STAT1

| 1

Seaborgium atom inhibits STAT1. 1 / 1

| 1

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➶

reach

"Mean intensity analyses of the images with image J software indicate that the p-STAT3 and p-STAT1 ratio is decreased significantly by cisplatin treatment in the OHC and SG, while SVA showed decreased ratio compared to oral PBS control sections."

30858408

Seaborgium atom affects NFKB1

| 1

Seaborgium atom inhibits NFKB1. 1 / 1

| 1

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➶

reach

"The research of the reporter gene assay on nuclear factor KB (NF-KB) showed that SC and SG oils inhibited NF-KB transcriptional activity."

30549613

Seaborgium atom affects IRF3

| 1

Seaborgium atom inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Chen Z, Rijnbrand R, Jangra RK, Devaraj SG, Qu L, Ma Y, Lemon SM, Li K: Ubiquitination and proteasomal degradation of interferon regulatory factor-3 induced by Npro from a cytopathic bovine viral diarrhea virus."

20538505

Scutellarin(1-) affects PYCARD

| 1

Scutellarin(1-) inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"H89 also augmented ATP induced formation of ASC specks and entirely reversed scutellarin mediated suppression of ASC specks."

29375379

Scutellarin(1-) affects NFKB1

| 1

Scutellarin(1-) inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"We reported recently that scutellarin could suppress NFkB and Notch signaling in activated microglia in their production of proinflammatory mediators in MCAO rats as well as in BV-2 cells [XREF_BIBR, XREF_BIBR]."

26608466

Schaftoside affects MYD88

| 1

Schaftoside inhibits MYD88. 1 / 1

| 1

---

➶

reach

"TLR4 and Myd88 signaling pathway was effectively suppressed by schaftoside."

30528467

Saxagliptin affects RELA

| 1

Saxagliptin inhibits RELA. 1 / 1

| 1

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➶

reach

"Saxagliptin also suppressed nuclear factor kappaB (NF-kappaB) p65 accumulation and inhibited its promoter activity."

30639312

Saquinavir affects RIPK1

| 1

Saquinavir inhibits RIPK1. 1 / 1

| 1

---

➶

medscan

"Addition of Saquinavir prevented the cleavage of endogenous RIPK1 at all times assayed."

26297639

Sanguinarine affects NFKB1

| 1

Sanguinarine inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Sulindac [75], aspirin and salicylate [76] specifically inhibit IkKB kinase activity, and sanguinarine has also been shown to inhibit NFkB activation at the level of IkB phosphorylation [77]."

12419552

Salt affects NLRP3

| 1

Salt inhibits NLRP3. 1 / 1

| 1

---

➶

eidos

"( A ) Sal inhibited TXNIP , NLRP3 , ASC and cleaved Caspase-1 in SN and striatum of PD mice by western blotting ( n = 3 ) ."

32432571

Salt affects MYD88

| 1

Salt inhibits MYD88. 1 / 1

| 1

---

➶

eidos

"( A ) Sal inhibited TLR4 , MyD88 , p-IkBalpha and p-NF-kappaB in SN and striatum of PD mice by western blotting ( n = 3 ) ."

32432571

Salsalate affects NFKB1

| 1

Salsalate inhibits NFKB1. 1 / 1

| 1

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➶

reach

"For example, Salsalate is broadly thought to inhibit NF-KB and showed efficacy in a recent trial [XREF_BIBR]."

28752547

Salsalate affects IKBKB

| 1

Salsalate inhibits IKBKB. 1 / 1

| 1

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➶

reach

"Clinical studies have found that Salsalate, a prodrug of salicylate which suppresses inflammation, attenuates IKKbeta and NF-kappaB activity, improves glycemic control in patients with type-2 diabetes, [XREF_BIBR] and alleviates IR."

28025032

Salinosporamide A affects NFKBIA

| 1

Salinosporamide A inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Marizomib treatment blocks the activation of NF-kappaB by SN-38 (the active metabolite of irinotecan) in CRC cells and results in the accumulation of the phosphorylated form of IkappaBalpha (a marker of inhibited NF-kappaB activity)."

21247382

Salicylic acid affects STAT1

| 1

Salicylic acid inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Salicylate did not inhibit the cytokine induction of NF-kappaB or STAT-1."

8940176

Salicylic acid affects MYD88

| 1

Salicylic acid inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Other signaling inhibitors including antiapoptotic protein A20, agonistic lipid A and its analogues, inhibitors of IkB2, salicylate and parthenolide, NF-B kinases inhibitor PS-1145, inhibitors of p38, JNK, anti-TLR, anti-MyD88 antibodies, are able to target the TIR domain of the TLR4 or the MyD88 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

28373830

Salicylic acid affects JUN

| 1

Salicylic acid inhibits JUN. 1 / 1

| 1

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➶

reach

"It was also recently reported that sodium salicylate and aspirin suppressed the activation of activator protein-1 in mouse epidermal cells exposed to UVB light [21]."

10594377

Salicylic acid affects CASP1

| 1

Salicylic acid inhibits CASP1. 1 / 1

| 1

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➶

reach

"AICAR and salicylate inhibited NLRP3 induction and caspase-1 activation, and as a result, IL-1beta secretion was reduced."

26196303

Salicylate affects STAT1

| 1

Salicylate inhibits STAT1. 1 / 1

| 1

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➶

reach

"On human endothelia, Sal B activated transcription factor 4 or 6, consequently regulated upwards glucose regulated protein 78, to protect the cellular damage from oxidative stress [XREF_BIBR]; Sal B suppressed JAK and STAT1 activation in endothelia to relive vessel inflammation [XREF_BIBR]."

23118797

Salicylate affects RELA

| 1

Salicylate inhibits RELA. 1 / 1

| 1

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➶

reach

"Western blot analysis revealed that Sal inhibited p65 and p38 activation together with peroxisome proliferator activated receptor (PPARgamma) up-regulation."

31849652

Salicylate affects MYD88

| 1

Salicylate inhibits MYD88. 1 / 1

| 1

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➶

reach

"The results showed that Sal inhibited the increase of TLR4, MyD88, p-IkappaBalpha and p-NF-kappaB in LPS induced BV2 cell (XREF_FIG)."

32432571

Salicylate affects JUN

| 1

Salicylate inhibits JUN. 1 / 1

| 1

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➶

reach

"Sal or OA could suppress apoptosis via their antioxidant properties; mammalian target of rapamycin (mTOR), nuclear factor-kappaB (NF-kappaB), Jun N-terminal kinase (JNK), and mitogen activated protein kinase (MAPK) signaling pathways; inhibition of excessive Ca 2+ influx; and so on [XREF_BIBR - XREF_BIBR]."

28638431

Salicylate affects CASP1

| 1

Salicylate inhibits CASP1. 1 / 1

| 1

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➶

reach

"Furthermore, SAL also decreased the activation of caspase-1 and inhibited the release of IL-1beta induced by lipopolysaccharide (LPS) and adenosine triphosphate (ATP) in human umbilical vein endothelial cell (HUVECs)."

32076940

Ruxolitinib affects MAP3K7

1 |

Ruxolitinib inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Ruxolitinib affects IFNB1

| 1

Ruxolitinib inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Inhibition of IFN-beta signaling by ruxolitinib reduced rli32 dependent intracellular bacterial growth, indicating a link between induction of the interferon system and bacterial physiology."

31594810

Ruxolitinib phosphate affects MAP3K7

1 |

Ruxolitinib phosphate inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Rutin affects RELA

| 1

Rutin inhibits RELA. 1 / 1

| 1

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➶

reach

"Moreover, troxerutin notably suppressed nuclear factor-kappaB (NF-kappaB) p65 transcriptional activation and release of inflammatory cytokines in HFD treated mouse livers."

28029143

Rotenone affects IFNB1

| 1

Rotenone inhibits IFNB1. 1 / 1

| 1

---

➶

medscan

"However, we found that pre-treatment of 293T cells with rotenone completely abolishes MPYS induction of IFNβ ( ). a. 293T cells were first transfected with HA-MPYS for 8 hrs."

21170271

Rosuvastatin affects NLRP3

| 1

Rosuvastatin inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Furthermore, rosuvastatin significantly inhibited the activation of NLRP3 inflammasome in this animal model."

29568858

Rosuvastatin affects NFKBIA

| 1

Rosuvastatin inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"As expected, OGD induced BV2 microglia exhibited significantly increased expression of inflammatory cytokines, such as TNF-alpha and COX2, as well as enhanced activation of pIkappaBalpha and pNF-kappaB, which could be significantly decreased by rosuvastatin and atorvastatin treatment."

30911291

Rosiglitazone affects STAT1

| 1

Rosiglitazone inhibits STAT1. 1 / 1

| 1

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➶

reach

"Park et al., have shown that rosiglitazone and 15d-PGJ 2 inhibit activation of JAK2 and STAT-1 in glia cells and astrocytes in a manner independent of PPAR-gamma activation."

24489087

Rosiglitazone affects JUN

| 1

Rosiglitazone inhibits JUN. 1 / 1

| 1

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➶

reach

"Rosiglitazone, a peroxisome proliferator activated receptor-gamma, inhibits the Jun NH (2)-terminal kinase and activating protein 1 pathway and protects the heart from ischemia and reperfusion injury."

11978649

Rosiglitazone affects IKBKB

| 1

Rosiglitazone inhibits IKBKB. 1 / 1

| 1

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➶

reach

"Rosiglitazone treatment significantly improved hepatic insulin sensitivity and inhibited the IKK-beta, NF-kappaB, and Ser307p-IRS-1 expressions in the liver (P < 0.05)."

25036911

Romidepsin affects RELA

| 1

Romidepsin inhibits RELA. 1 / 1

| 1

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➶

reach

"The romidepsin induced p65 occupancy at the CXCL8 promoter at 48 h was inhibited by Bay 117085, indicating that the HDI induced p65 promoter occupancy is dependent on IKK activity, as we have previously observed in vorinostat treated OC cells [XREF_BIBR]."

29050320

Roflumilast affects JAK1

| 1

Roflumilast inhibits JAK1. 1 / 1

| 1

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➶

reach

"Moreover, roflumilast significantly suppressed the activation of signal transducer and activator of transcription 3 (STAT3) and its upstream Janus kinase 1 and Janus kinase 2."

28650427

Rocaglamide affects RELA

1 |

Rocaglamide inhibits RELA. 1 / 1

1 |

---

➶

tas

No evidence text available

19839614

Ritonavir affects TRAF6

| 1

Ritonavir inhibits TRAF6. 1 / 1

| 1

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➶

reach

"In addition, the HIV PI ritonavir abrogated the interferon-gamma-mediated degradation of the RANKL nuclear adapter protein TRAF6, a physiological block to RANKL activity."

19095956

Ritonavir affects RELA

1 |

Ritonavir inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

16174765

Ritonavir affects NFKB1

1 |

Ritonavir inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

16174765

Ritanserin affects FOS

| 1

Ritanserin inhibits FOS. 1 / 1

| 1

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➶

reach

"DOI (0.5 mg/kg) also induced c-Fos in the SCN and the induction was prevented by ritanserin and ketanserin."

9500663

Rifaximin affects MYD88

| 1

Rifaximin inhibits MYD88. 1 / 1

| 1

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➶

reach

"Rifaximin at 0.1, 1.0, and 10 muM inhibited TLR4 expression (-33, -50, and -75%) and reduced MyD88 (-29, -60, and -81%) and TAK1 expression (-37, -63, and -79%) in a concentration dependent manner, when compared with the TcdA group."

27242527

Rifampicin affects NLRP3

| 1

Rifampicin inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Moreover, western blot analysis verified that rifampicin pretreatment suppressed NLRP3 inflammasome activation via inhibiting caspase-1 cleavage and protein expression of NLRP3."

26086368

Ribosomal RNA affects TLR7

| 1

Ribosomal RNA inhibits TLR7. 1 / 1

| 1

---

➶

eidos

"Interestingly , TLR7 was also shown to be activated by cellular mRNA but not by rRNA or tRNA , highlighting the possible importance of cellular RNA modifications in preventing stimulation of antiviral RNA receptors ( Kariko et al. 2005 ) ."

19882216

Ribose affects TLR7

| 1

Ribose inhibits TLR7. 1 / 1

| 1

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➶

reach

"Therefore, the ribose 2′‐O‐methyl group on the first nucleotide marks viral RNA as “self” which prevents the activation of the RNA sensors Mda5, TLR7, and RIG‐I, as well as avoids recognition of RNA by the interferon‐induced translation inhibitors, IFIT1 and IFIT2 (Figure 2)."

31694072

Ribose affects IFIH1

| 1

Ribose inhibits IFIH1. 1 / 1

| 1

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➶

reach

"Therefore, the ribose 2′‐O‐methyl group on the first nucleotide marks viral RNA as “self” which prevents the activation of the RNA sensors Mda5, TLR7, and RIG‐I, as well as avoids recognition of RNA by the interferon‐induced translation inhibitors, IFIT1 and IFIT2 (Figure 2)."

31694072

Ribonucleic acid affects JAK1

| 1

Ribonucleic acid inhibits JAK1. 1 / 1

| 1

---

➶

trips

"Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway."

21861134

Ribonucleic acid affects ITCH

| 1

Ribonucleic acid inhibits ITCH. 1 / 1

| 1

---

➶

trips

"Consistently, overexpression of Itch increases cell survival and inhibits caspase 3 activity, whereas downregulation of Itch by RNA interference has the opposite effect, increasing cell death and apoptosis."

20392206

Ribitol affects PYCARD

| 1

Ribitol inhibits PYCARD. 1 / 1

| 1

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➶

reach

"Xylitol also inhibited ASC and AIM2 proteins and formation of ASC puncta."

26876350

Retinoic acid affects TYK2

| 1

Retinoic acid inhibits TYK2. 1 / 1

| 1

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➶

reach

"Conversely, RA did not inhibit the constitutive activation of JAK1, TYK2, STAT3 and ERK1/2, ruling out that the JAK and STAT and MAPK pathways may mediate the antiproliferative activity of RA."

15254731

Retinoic acid affects MYD88

| 1

Retinoic acid inhibits MYD88. 1 / 1

| 1

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➶

reach

"In addition, the expression of the RA induced gene Tgm2 was lower in MyD88 -/- PP-DC as compared to wild type PP-DC, whereas Fabp4 mRNA, a PPARgamma-RXR target gene 10, was expressed at similar levels in MyD88 -/- and wild type PP-DC (XREF_SUPPLEMENTARY)."

21596042

Retinoic acid affects MAVS

| 1

Retinoic acid inhibits MAVS. 1 / 1

| 1

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➶

reach

"Moreover, nsp11 antagonizes type I IFN, specifically IFNβ production, activated by the retinoic acid inducible gene 1 like receptor, showing substrate specificity toward Mitochondrial Antiviral Signaling proteins (MAVS) and RIG-I (transcripts and proteins), and demonstrating that this activity was associated to the endoribonuclease activity of this protein in which transfection mutant viruses were unable to degrade MAVS mRNA and impair IFNβ production (53)."

30842948

Retinoic acid affects JUN

| 1

Retinoic acid inhibits JUN. 1 / 1

| 1

---

➶

reach

"Moreover, RA is known to inhibit the binding of activator protein 1 to the cyclic AMP response element in the COX-2 promoter [XREF_BIBR], so inhibiting phorbol-ester mediated induction of COX-2 gene transcription, whose intracellular levels consequently fall, reducing also prostaglandin production [XREF_BIBR]."

25879031

Retinoic acid affects JAK1

| 1

Retinoic acid inhibits JAK1. 1 / 1

| 1

---

➶

reach

"Conversely, RA did not inhibit the constitutive activation of JAK1, TYK2, STAT3 and ERK1/2, ruling out that the JAK and STAT and MAPK pathways may mediate the antiproliferative activity of RA."

15254731

Retinoic acid affects IRF7

| 1

Retinoic acid inhibits IRF7. 1 / 1

| 1

---

➶

reach

"Similarly, RA can inhibit interferon regulatory factor 7 (IRF-7) signaling, which is associated with deteriorated lupus."

30081517

Resveratrol affects PYCARD

| 1

Resveratrol inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Resveratrol inhibits oligomerization of ASC."

30637441

Resveratrol affects MAPK14

| 1

Resveratrol inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"In addition, high glucose-induced activation of ERK and p38 MAPK signaling pathways as well as the transcription factor NF-κB could also be suppressed by resveratrol."

27278736

Resveratrol affects IKBKB

| 1

Resveratrol inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Metformin and resveratrol blocked JNK and IKKbeta inflammatory signaling and effectively preserved PDE3B activity, presenting another pathway through which to reduce cAMP accumulation."

27343375

Resveratrol affects IFNB1

| 1

Resveratrol inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"And the results of ELISA and western blot confirmed that BX795 and resveratrol were able to effectively inhibit the production of IFN-beta and inflammatory cytokines, respectively."

29050325

Resveratrol affects FOS

1 |

Resveratrol inhibits FOS. 1 / 1

1 |

---

➶

ctd

No evidence text available

14623829

Resveratrol affects CHUK

1 |

Resveratrol inhibits CHUK. 1 / 1

1 |

---

➶

ctd

No evidence text available

24020126

Resolvin D1 affects NFKB1

| 1

Resolvin D1 inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Recent studies have demonstrated that resolvin D1 derived from DHA stimulates the efferocytosis by facilitating the degradation of p105, a precursor of p50 subunit of NF- B and subsequently predominant formation of p50-p50 homodimer."

29381475

Resiquimod affects NFKBIA

| 1

Resiquimod inhibits NFKBIA. 1 / 1

| 1

---

➶

eidos

"R848 induced moderate Caspase-1 activation ( Figure 3D ) and moderate IkappaBalpha degradation ( 3E ) , whereas TDB induced greater Caspase-1 activation but less IkappaBalpha degradation ."

27793997

Regorafenib affects JUN

| 1

Regorafenib inhibits JUN. 1 / 1

| 1

---

➶

reach

"Regorafenib is effective against neuroblastoma in vitro and in vivo and inhibits the RAS and MAPK, PI3K/Akt/mTOR and Fos and Jun pathways."

32457362

Reactive oxygen species affects TLR7

| 1

Reactive oxygen species inhibits TLR7. 1 / 1

| 1

---

➶

reach

"The specific mechanism is still unclear, but some people believe that the internalization of the virus triggers the production of cellular hydrogen peroxide, and the NOX2-dependent ROS production inhibits the antiviral signaling network by modifying the Toll-like receptor 7 (63)."

32625169

Reactive oxygen species affects TICAM1

| 1

Reactive oxygen species inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"Decreased early recruitment of peritoneal neutrophils and macrophages and decreased late ROS production in TRIF -/- neonates in response to E coli neonatal sepsis."

25548220

Reactive oxygen species affects STAT1

| 1

Reactive oxygen species inhibits STAT1. 1 / 1

| 1

---

➶

reach

"For example, excessive ROS inhibits IFN-gamma-induced JAK2 and STAT1 activation in neurons."

25535282

Reactive oxygen species affects PYCARD

| 1

Reactive oxygen species inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"UVB treatment significantly increased the generation of reactive oxygen species (ROS) in cultured ASCs, and inhibition of ROS generation by diphenyleneiodonium chloride (DPI) significantly attenuated UVB induced ASC stimulation."

22784094

Reactive oxygen species affects MAPK8

| 1

Reactive oxygen species inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"In addition, the knockdown of cFLIP L in TNF-alpha pre-stimulated cells showed a drastic elevation in ROS generation and ITCH activation (XREF_FIG), but pre-treatment with NAC, abolishes JNK1 and ITCH activation (XREF_SUPPLEMENTARY)."

26972597

Reactive oxygen species affects MAP3K7

| 1

Reactive oxygen species inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"We next attempted to reduce ROS and tested whether reduction of ROS could rescue the apoptosis and tight junction disruption in the TAK1 deficient epithelium."

20855879

Reactive oxygen species affects ITCH

| 1

Reactive oxygen species inhibits ITCH. 1 / 1

| 1

---

➶

reach

"In addition, the knockdown of cFLIP L in TNF-alpha pre-stimulated cells showed a drastic elevation in ROS generation and ITCH activation (XREF_FIG), but pre-treatment with NAC, abolishes JNK1 and ITCH activation (XREF_SUPPLEMENTARY)."

26972597

Reactive oxygen species affects IRF3

| 1

Reactive oxygen species inhibits IRF3. 1 / 1

| 1

---

➶

reach

"SOD2 deficiency mediated ROS accumulation potently inhibits RIG-I-like receptor (RLR)-induced innate immune responses through the regulation of nuclear factor-kappa B (NF-kappaB) and interferon regulatory factor-3 activation."

28574756

Reactive oxygen species affects IKBKB

1 |

Reactive oxygen species inhibits IKBKB. 1 / 1

1 |

---

➶

bel

"In addition, IKK? and IKK? contain a redox sensitive cysteine residue that is sensitive to oxidative modification. Oxidative modification of this residue by ROS results in inactivation of IKK (Rossi et al., 2000; Kapahi et al., 2000)"

18355884

Reactive oxygen species affects CHUK

1 |

Reactive oxygen species inhibits CHUK. 1 / 1

1 |

---

➶

bel

"In addition, IKK? and IKK? contain a redox sensitive cysteine residue that is sensitive to oxidative modification. Oxidative modification of this residue by ROS results in inactivation of IKK (Rossi et al., 2000; Kapahi et al., 2000)"

18355884

Raloxifene affects RELA

| 1

Raloxifene inhibits RELA. 1 / 1

| 1

---

➶

reach

"Moreover, raloxifene inhibited constitutive nuclear factor-kappaB (NF-kappaB) activity in myeloma cells by removing p65 from its binding sites through estrogen receptor alpha interaction with p65."

16497877

Raloxifene hydrochloride affects STAT1

| 1

Raloxifene hydrochloride inhibits STAT1. 1 / 1

| 1

---

➶

trips

"However, Evista did not inhibit STAT1, STAT2, STAT4 and STAT6 phosphorylation elicited by IFN-α, IFN-γ and IL-4, as well as phosphorylation of STAT3 induced by LIF in MCF-7 cell lines."

28711499

Raloxifene hydrochloride affects RELA

1 |

Raloxifene hydrochloride inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

16497877

Radicicol affects NFKB1

| 1

Radicicol inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Treatment of radicicol to THP-1 cells produced a strong inhibition of NF-KB and AP-1, while NF-IL6 was not significantly affected by radicicol."

11562079

Quinpirole affects FOS

| 1

Quinpirole inhibits FOS. 1 / 1

| 1

---

➶

reach

"Quinpirole attenuates striatal c-fos induction by 5-HT, opioid and muscarinic receptor agonists."

9669494

Quinoxaline affects IKBKB

| 1

Quinoxaline inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Recent studies by us also suggest that the quinoxaline urea analog 13-197 inhibits the constitutively active form of IKKbeta which is an emerging target for therapeutic development."

23963361

Quinolinic acid affects FOS

| 1

Quinolinic acid inhibits FOS. 1 / 1

| 1

---

➶

reach

"In this regard, it is of interest to mention the recent study of Baum and Everitt (1) that copulatory behavior activates c-fos expression in both the mPOA and mAMG, and that unilateral quinolinic acid lesions in the mAMG did not reduce c-fos ex- pression in both ipsi- and contralateral sides of the mPOA, and vice versa (1)."

7878127

Quinoline affects MAPK8

1 |

Quinoline inhibits MAPK8. 1 / 1

1 |

---

➶

ctd

No evidence text available

15737997

Quinazolines affects MAPK14

1 |

Quinazolines inhibits MAPK14. 1 / 1

1 |

---

➶

ctd

No evidence text available

18817365

Quinapril affects RELA

| 1

Quinapril inhibits RELA. 1 / 1

| 1

---

➶

reach

"Neither quinapril nor simvastatin given for 7 d produced a suppression of ROS generation, intranuclear NF-kappa B, p65, or CRP, and these two agents did not alter cellular I kappa B either."

12970329

Quinalizarin affects RELA

| 1

Quinalizarin inhibits RELA. 1 / 1

| 1

---

➶

reach

"Quinalizarin inhibited binding of p65 and the promoter of SHP-1, and decreased the activities of SHP-1 promoter and SHP-1."

26781335

Quinacrine affects JUN

| 1

Quinacrine inhibits JUN. 1 / 1

| 1

---

➶

reach

"Specific suppression of the transcription factor AP-1 by mepacrine."

| PMC

Quinacrine affects FOS

| 1

Quinacrine inhibits FOS. 1 / 1

| 1

---

➶

reach

"While mepacrine treatment alone led to increased concentrations of c-Jun within the nuclear compartment, c-Fos translocation into the nucleus was blocked in synoviocytes treated with mepacrine and stimulated with PMA."

14677173

Quercetin affects TLR7

| 1

Quercetin inhibits TLR7. 1 / 1

| 1

---

➶

reach

"Quercetin and oseltamivir increased cell viability and reduced the expression levels of TLR7 signal pathway."

22924574

Quercetin affects TBK1

1 |

Quercetin inhibits TBK1. 1 / 1

1 |

---

➶

ctd

No evidence text available

19426678

Quercetin 3-O-beta-D-galactopyranoside affects CASP1

| 1

Quercetin 3-O-beta-D-galactopyranoside inhibits CASP1. 1 / 1

| 1

---

➶

reach

"In addition, EWD, isorhamnetin, and hyperoside inhibited caspase-1."

28160865

Pyruvic acid affects CASP1

| 1

Pyruvic acid inhibits CASP1. 1 / 1

| 1

---

➶

reach

"The SE induced caspase-1 activation was significantly reduced when rats were treated with oxaloacetate or pyruvate plus oxaloacetate."

21185899

Pyrrolidine affects TICAM1

| 1

Pyrrolidine inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"In this regard Pepinh- TRIF, Pepinh- MYD and pyrrolidine dithiocarbamate (PDTC) were used to inhibit TRIF, MYD88 and NF-kB pathways."

27575706

Pyrrolidine affects NFKBIA

| 1

Pyrrolidine inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Overall, the results obtained in this study demonstrate that pyrrolidine dithiocarbamate inhibits the degradation of IkappaB-alpha degradation, thus inhibiting NF-kappaB activation.Metal ion chelation by pyrrolidine dithiocarbamate is unlikely to have provided major beneficial actions in this model of renal ischemia and reperfusion as it have already been demonstrated that it is not possible to overcome pyrrolidine dithiocarbamate mediated blockade of NF-kappaB activation using Co 2+, Mn 2+ or Fe 2+ (Ziegler-Heitbrock et al., 1993)."

14660032

Pyrrolidine affects MYD88

| 1

Pyrrolidine inhibits MYD88. 1 / 1

| 1

---

➶

reach

"In this regard Pepinh- TRIF, Pepinh- MYD and pyrrolidine dithiocarbamate (PDTC) were used to inhibit TRIF, MYD88 and NF-kB pathways."

27575706

Pyrrole-2-carboxylic acid affects STAT1

| 1

Pyrrole-2-carboxylic acid inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Gel-shift assays revealed that PYC inhibits IFN-gamma-mediated activation of Stat1, thus suggesting a transcriptional regulation of inducible ICAM-1 expression by PYC."

11281289

Pyrrole-2-carboxylic acid affects IFNB1

| 1

Pyrrole-2-carboxylic acid inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"In the present study, we showed that PYC significantly suppressed the production of proinflammatory cytokines, including TNF-alpha, IL-6 and IL-1beta (XREF_FIG) but not IFN-beta (data not shown)."

26367267

Pyrimidines affects MAPK14

1 |

Pyrimidines inhibits MAPK14. 1 / 1

1 |

---

➶

ctd

No evidence text available

12534346

Pyrimidine affects STAT1

| 1

Pyrimidine inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Additionally, the pyrazolyl pyrimidine AZD1480, which potently inhibits JAK1 (IC 50 value of 1.3 nM) and JAK2 (IC 50 value of 0.4 nM) 186, differentially suppressed STAT1, STAT3, STAT5 and STAT6 activation at 0.1-5 muM concentration in prostate, ovarian, glioma, and breast cancer cells in vitro XREF_BIBR, XREF_BIBR."

23903221

Pyridoxine affects NFKB1

| 1

Pyridoxine inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Functional studies showed that vitamin B6 vitamers reduced skin neutrophil infiltration, oxidative stress and Nfkb activity in two zebrafish models of skin inflammation."

32126244

Pyridazine affects IKBKB

| 1

Pyridazine inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"By the optimization of the 3- and 6-position of imidazo [1,2-b] pyridazine scaffold, cell-free IKKbeta inhibitory activity and TNFalpha inhibitory activity in THP-1 cell increased."

20675134

Pyrazoles affects MAPK14

1 |

Pyrazoles inhibits MAPK14. 1 / 1

1 |

---

➶

ctd

No evidence text available

12534346

Pyranone affects IKBKB

1 |

Pyranone inhibits IKBKB. 1 / 1

1 |

---

➶

ctd

No evidence text available

21296074

Pyraclofos affects NFKBIA

| 1

Pyraclofos inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"IKBa demonstrated strong inward rectification and was inhibited by Ba (2+) in a dose- and voltage dependent fashion, with the K (d) decreasing with hyperpolarization."

17091215

Pyocyanin affects NLRP3

| 1

Pyocyanin inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"The bacterial pigment pyocyanin inhibits the NLRP3 inflammasome through intracellular reactive oxygen and nitrogen species."

29414783

Pyocyanin affects CASP1

| 1

Pyocyanin inhibits CASP1. 1 / 1

| 1

---

➶

reach

"This might be due to reduced caspase-1 activation by pyocyanin."

28396663

Purpurogallin affects FOS

| 1

Purpurogallin inhibits FOS. 1 / 1

| 1

---

➶

reach

"In this context, the downregulation of c-Fos by purpurogallin at day 1 was followed by downregulation of NFATc1 at day 2-3 (XREF_FIG B)."

29463002

Puromycin(1+) affects FOS

| 1

Puromycin(1+) inhibits FOS. 1 / 1

| 1

---

➶

reach

"Local infusion of puromycin via micropipette recording electrodes blocks protein synthesis in a small region, documented by a blockade of activity induced c-fos synthesis around the recording micropipette (XREF_FIG)."

22350812

Purine-6-thiol affects RELA

| 1

Purine-6-thiol inhibits RELA. 1 / 1

| 1

---

➶

reach

"We found that 6-MP attenuates p65 activity indicating that 6-MP directly affects the transcriptional activity of NFkappaB."

26084512

Punicalagin affects CASP1

| 1

Punicalagin inhibits CASP1. 1 / 1

| 1

---

➶

reach

"In addition, punicalagin did not inhibit caspase-1 activity after NLRP3 inflammasome activation (XREF_FIG), but it completely prevented release of active caspase-1 (p10 subunit), ASC, and NLRP3 inflammasome components (XREF_FIG)."

26868913

Puerarin affects NFKB1

1 |

Puerarin inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

17887948

Psoralen affects ITCH

| 1

Psoralen inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Furthermore, psoralen + ultraviolet A (PUVA) therapy downregulates the mu opioid system and restores the kappa opioid system in patients with atopic dermatitis, and may contribute to the beneficial effect of phototherapy with respect to decreasing itch."

26739556

Pseudouridine affects IFNB1

| 1

Pseudouridine inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"However, complete substitution of pseudouridine for uridine (5ppp/Psi) also reduced the IFN-beta response to the 5ppp containing mRNA (XREF_FIG)."

27651356

Pseudouridine affects IFIH1

| 1

Pseudouridine inhibits IFIH1. 1 / 1

| 1

---

➶

reach

"In addition, abundant cellular RNAs, such as tRNAs and rRNAs, are extensively modified with unusual bases, such as pseudouridine, which prevent the activation of RIG-I and MDA5 (ReF."

18989317

Protein affects STAT2

| 1

Protein inhibits STAT2. 1 / 1

| 1

---

➶

eidos

"The DENV NS5 protein can also mediate STAT2 degradation via the ubiquitin-proteasome pathway ( 139 ) , consistent with a similar report regarding NS5 of the Zika virus ( ZIKV ) , another flavivirus ( 140 , 141 ) ."

29312301

Protein affects STAT1

| 1

Protein inhibits STAT1. 1 / 1

| 1

---

➶

eidos

"Nipah virus produces two proteins that prevent STAT1 from translocating into the nucleus as well as another protein that sequesters STAT1 present in the nucleus , obstructing the activation of interferon-stimulated genes ( Shaw et al. 2004 ) ."

| PMC

Protein affects IKBKB

| 1

Protein inhibits IKBKB. 1 / 1

| 1

---

➶

eidos

"It is possible that the M protein sequesters IKKb and prevents formation of a fully functional IKK signalsome , which impairs NF-kB signaling ."

17705188

Protein affects IFIH1

| 1

Protein inhibits IFIH1. 1 / 1

| 1

---

➶

eidos

"The negative regulation of MDA5 in uninfected cells is proposed to be maintained by dihydroxyacetone kinase ( DAK ) , a protein which specifically inhibits MDA5 but not RIG-I mediated signaling , and most likely by other yet undiscovered regulators ( Diao et al. 2007 ) ."

19882216

Protein kinase inhibitor affects RELA

1 |

Protein kinase inhibitor inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

21173233

Protein kinase inhibitor affects NFKB1

1 |

Protein kinase inhibitor inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

21173233

Protein kinase inhibitor affects MAPK14

1 |

Protein kinase inhibitor inhibits MAPK14. 1 / 1

1 |

---

➶

ctd

No evidence text available

27807932

Protein kinase inhibitor affects IKBKB

1 |

Protein kinase inhibitor inhibits IKBKB. 1 / 1

1 |

---

➶

ctd

No evidence text available

28924041

Prostaglandin J2 affects IKBKB

| 1

Prostaglandin J2 inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Previous studies demonstrated that PGJ2 directly inhibits IKKbeta activity by forming an adduct with Cys 179 in IKKbeta."

21078906

Prostaglandin J2 affects FOS

| 1

Prostaglandin J2 inhibits FOS. 1 / 1

| 1

---

➶

reach

"N-myc suppression along with cellcycle arrest by PGJ2 is reported in human neuroblastoma GOTO cells 152 Prostaglandins 1996:52, September PGj2 Induces c-fos and Apoptosis : Higashivama et al. (25)."

8908616

Prostaglandin I2 affects MAPK14

| 1

Prostaglandin I2 inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"In human aortic smooth muscle cells, protein blotting analysis showed that PGI(2) overproduction decreased the levels of phosphorylated p38 mitogen-activated protein kinase (P-p38 mitogen-activated protein kinase) (2.0-fold versus 0.83-fold relative to control)."

17303142

Prostaglandin E2-UM affects STAT2

| 1

Prostaglandin E2-UM inhibits STAT2. 1 / 1

| 1

---

➶

reach

"CXCL10 production was preceded by lysosomal rupture as shown by time dependent co-localization of galectin-3 and chitosan and slowed autophagy flux, and specifically depended on IFN-beta paracrine activity and STAT-2 activation that could be suppressed by PGE 2."

28340358

Prostaglandin E2-UM affects NFKB1

| 1

Prostaglandin E2-UM inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Furthermore, we have observed that the degradation of p105 that is inhibited by PGE 2 is not restored by the presence of Sorafenib (data not shown)."

20637838

Prostaglandin E2-UM affects IFNB1

| 1

Prostaglandin E2-UM inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"CXCL10 production was preceded by lysosomal rupture as shown by time dependent co-localization of galectin-3 and chitosan and slowed autophagy flux, and specifically depended on IFN-beta paracrine activity and STAT-2 activation that could be suppressed by PGE 2."

28340358

Prostaglandin E2 affects RELA

| 1

Prostaglandin E2 inhibits RELA. 1 / 1

| 1

---

➶

reach

"DNJ increased the levels of prostaglandin E2, COX-1, COX2, and reduced the levels of and NF-kappaB p65 (P < 0.05)."

29725297

Prostaglandin E2 affects IFNB1

| 1

Prostaglandin E2 inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Treating mice with prostaglandin E2 and zileuton, which limit IFNbeta induction, confers tolerance to Mtb [XREF_BIBR] and zileuton has been developed as a drug that can be administered to TB patients to enhance the efficacy of antibiotic treatment [XREF_BIBR]."

27500737

Prostaglandin A1 affects NFKB1

| 1

Prostaglandin A1 inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Sodium salicylate and prostaglandin A1 that inhibit NFk-B activity and restore growth control are experimental therapies for cylindromas."

27559531

Propranolol affects CHUK

| 1

Propranolol inhibits CHUK. 1 / 1

| 1

---

➶

reach

"Sulfapyridine and propranolol appeared to inhibit NIK and IKKalpha, 2 essential kinases in the non canonical pathway, while having no effect on IKKbeta, a key mediator of the canonical pathway."

29374256

Propranolol affects CASP1

| 1

Propranolol inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Propanolol treatment did not block caspase-1 activation induced by ATP in LPS primed macrophages, suggesting that inhibition of PAP-1 does not account for the effect of BEL to block Nlrp3 dependent caspase-1 activation (XREF_FIG)."

20160900

Propionic acid affects CASP1

| 1

Propionic acid inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Propionate had no effects on 7-Ket-increased caspase-1 activity, but inhibited CHC enhanced caspase-1 activity."

29475132

Propan-2-ol affects JUN

1 |

Propan-2-ol inhibits JUN. 1 / 1

1 |

---

➶

ctd

No evidence text available

22020770

Propan-2-ol affects FOS

1 |

Propan-2-ol inhibits FOS. 1 / 1

1 |

---

➶

ctd

No evidence text available

22020770

Progesterone affects TICAM1

| 1

Progesterone inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"By inhibiting miR-155 expression progesterone can down-regulate both MyD88 and TRIF dependent signaling pathways as well as IL-6 and IFN-beta production."

23372573

Progesterone affects NLRP3

| 1

Progesterone inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"These results are in agreement with another report which indicates that progesterone therapy induces a switch in microglia phenotype from pro inflammatory to anti-inflammatory and suppresses NLRP3 inflammasome in cuprizone induced demyelination mice (Aryanpour et al., 2017)."

31397329

Progesterone affects NFKB1

| 1

Progesterone inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"High levels of estradiol, HCG and progesterone during the pregnancy can inhibit secretion of such NFkB induced inflammatory cytokines as IL-1, -2, -3, -5, -8, interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) by Mphis and T cells, while enhance the secretion of the monocyte deactivating cytokine, IL-10 [XREF_BIBR - XREF_BIBR]."

19683334

Progesterone affects MAPK8

1 |

Progesterone inhibits MAPK8. 1 / 1

1 |

---

➶

ctd

No evidence text available

18486349

Progesterone affects MAPK14

| 1

Progesterone inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Progesterone could repress the activation of iNOS through P38mitogen activated protein kinase pathway within polymorphonuclear leukocytes (P<0.05), which could be blocked by SB203580 (P<0.01), but not by actinomycin D (P>0.05)."

20155468

Progesterone affects JUN

| 1

Progesterone inhibits JUN. 1 / 1

| 1

---

➶

reach

"Progesterone does not block the induction of c-jun or c-myc mRNA by estradiol."

1375896

Progesterone affects IFNB1

| 1

Progesterone inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"By inhibiting miR-155 expression progesterone can down-regulate both MyD88 and TRIF dependent signaling pathways as well as IL-6 and IFN-beta production."

23372573

Progesterone affects FOS

| 1

Progesterone inhibits FOS. 1 / 1

| 1

---

➶

reach

"However, 24 h of progesterone exposure reduced the magnitude of c-fos and fosB stretch induction at both the 400 nM and 1 microM doses."

15126239

Prodrug affects IKBKB

| 1

Prodrug inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"IMD-1041 is a prodrug of IMD-0354 that was developed by the Institute of Medicinal Molecular Design and specifically inhibits IKKb in in-vivo [8] and in-vitro experiments [9] ."

21072674

Probenecid affects FOS

| 1

Probenecid inhibits FOS. 1 / 1

| 1

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➶

reach

"Systemic kynurenine + probenecid treatment significantly diminishes nitroglycerin induced increase of c-fos immunoreactivity in the brainstem."

16897600

Pregabalin affects FOS

| 1

Pregabalin inhibits FOS. 1 / 1

| 1

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➶

reach

"Consistent with behavioral data, intrathecal morphine had no effect on the light induced c-Fos + neurons, but intrathecal pregabalin significantly reduced the number of c-Fos + neurons (vehicle, 26.4 +/- 0.4, n = 3 rats; morphine, 24.0 +/- 2.1, n = 5 rats; pregabalin, 13.5 +/- 1.0, n = 4 rats; p < 0.01)."

29468190

Prazosin affects STAT1

| 1

Prazosin inhibits STAT1. 1 / 1

| 1

---

➶

medscan

"The phosphorylation of Jak2 was prevented by the alpha(1) receptor antagonists prazosin and chloroethylclonidine, but not by WB4101, and that of STAT1 was inhibited by prazosin and the Jak2 inhibitor AG490."

10652206

Prazosin affects JUN

| 1

Prazosin inhibits JUN. 1 / 1

| 1

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➶

reach

"Prazosin reduced FCL (SD)-induced elevations of c-jun and c-fos, but not NGFI-A, mRNA."

11072104

Pravastatin affects JUN

| 1

Pravastatin inhibits JUN. 1 / 1

| 1

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➶

reach

"Moreover, pravastatin down-regulated the radiation induced activation of the transcription factor activator protein 1 but not of nuclear factor-kappaB."

15850408

Potassium(1+) affects TBK1

| 1

Potassium(1+) inhibits TBK1. 1 / 1

| 1

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➶

reach

"Dihydrostibestrol induced a marked increase and a slight decrease in K+ and Na+ contents respectively, lowering the Na/K ration."

943814

Potassium(1+) affects ITCH

| 1

Potassium(1+) inhibits ITCH. 1 / 1

| 1

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➶

reach

"The major findings of this study are as follows : (1) inhibition of M/K v 7 potassium currents causes itch sensation; (2) CQ is an inhibitor of M/K v 7 currents, and inhibitory mechanism involves TRPA1 mediated Ca 2+ influx; (3) CQ induced inhibition of M/K v 7 induces hyper-excitability of DRG neurons, which is likely the mechanism for CQ induced itch sensation."

32694980

Potassium iodide affects NFKBIA

| 1

Potassium iodide inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Together, these results demonstrate that IkappaBalpha M/M KI mutations disrupt the IkappaBalpha autoinhibitory loop in neurons by delaying resynthesis of IkappaBalpha, leading to an enhancement of NF-kappaB activity in response to acute activating stimuli."

21663635

Potassium dihydrogen phosphate affects MAPK8

| 1

Potassium dihydrogen phosphate inhibits MAPK8. 1 / 1

| 1

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➶

reach

"Furthermore, MKP inhibition was shown to potentiate apoptosis in rat mesangial cells by shifting the transient activation of JNK-1 to a persistent time course [26]."

12801510

Potassium chloride affects PYCARD

| 1

Potassium chloride inhibits PYCARD. 1 / 1

| 1

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➶

reach

"47) or increased extracellular concentrations of KCl inhibited the formation of ASC specks, demonstrating that Mtb infection results in potassium efflux driven activation of the NLRP3 inflammasome."

32385301

Porphyrin affects NLRP3

| 1

Porphyrin inhibits NLRP3. 1 / 1

| 1

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➶

reach

"But, similar to our findings in podocytes or glomeruli, a recent report provided evidence that scavenging of extracellular O 2 *- by SOD mimetic Mn (III) tetrakis (N-ethylpyridinium-2-yl) porphyrin (MnTE-2-PyP) could prevent NLRP3 inflammasome activation in a model of hypoxia induced pulmonary hypertension [XREF_BIBR]."

24140862

Ponatinib affects JAK1

| 1

Ponatinib inhibits JAK1. 1 / 1

| 1

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➶

reach

"Ponatinib alone suppressed pStat3 (Y705) as efficiently as the combination of PD173074 and ruxolitinib in the presence of erlotinib or AZD6244, suggesting that ponatinib potently inhibits FGFRs and JAK1 in PC-9 cells."

25065853

Polyphenol affects TICAM1

| 1

Polyphenol inhibits TICAM1. 1 / 1

| 1

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➶

sparser

"Resveratrol (RES) (3,4′,5-trihydroxy- trans -stilbene) is a polyphenol that specifically inhibits TRIF but not MyD88 signaling coupled to TLRs by targeting TANK-binding kinase 1 and RIP1 in TRIF complex, accompanied by reduced NF-κB activation ( xref – xref )."

19559490

Polyphenol affects MYD88

| 1

Polyphenol inhibits MYD88. 1 / 1

| 1

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➶

reach

"The polyphenol component epigallocatechin-3-gallate (EGCG) in green tea is an inhibitor of kinase TBK1 and can suppress the MyD88 signal and the MyD88-independent signal pathway [109]."

23436141

Polyphenol affects IKBKB

| 1

Polyphenol inhibits IKBKB. 1 / 1

| 1

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➶

eidos

"Furthermore , the polyphenol inhibits IKKbeta activity by inducing its S-nitrosylation [ 84 ] ."

29486318

Polyinosinic:polycytidylic acid affects IFNB1

| 1

Polyinosinic:polycytidylic acid inhibits IFNB1. 1 / 1

| 1

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➶

reach

"GSK3beta deficiency in mouse embryonic fibroblasts significantly reduces polyinosinic : polycytidylic acid induced IFN-beta and IFN stimulated gene expression, which is caused by diminished phosphorylation of Src at tyrosine 416."

31619538

Polyinosinic-polycytidylic acid affects TRAF6

| 1

Polyinosinic-polycytidylic acid inhibits TRAF6. 1 / 1

| 1

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➶

reach

"One month post transplantation and prior to administration of polyinosinic-polycytidylic acid (pIpC) to induce Traf6 deletion, CD45.2 + chimerism was comparable in recipients with BM cells from Traf6 -/- Mx1Cre + mice and Mx1Cre + mice."

29386112

Polyinosinic-polycytidylic acid affects IFIH1

| 1

Polyinosinic-polycytidylic acid inhibits IFIH1. 1 / 1

| 1

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➶

reach

"Virus induced and polyinosinic-polycytidylic acid induced activation of MDA5 were severely impaired in PACT-knockout cells and attenuated in PACT-knockdown cells, but they were potentiated when PACT was overexpressed."

28760879

Polyinosinic acid affects RELA

| 1

Polyinosinic acid inhibits RELA. 1 / 1

| 1

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reach

"RLP significantly degraded inhibitory kappaBalpha in the cytoplasm and activated nuclear factor-kappaB (NF-kappaB) p65 in the nucleus of HUVECs with increased luciferase activity of NF-kappaB, all of which were reversed by cilostazol (10 microM), BAY 11-7085, and polyinosinic acid."

15525793

Poly(vinyl alcohol) polymer affects CASP1

| 1

Poly(vinyl alcohol) polymer inhibits CASP1. 1 / 1

| 1

---

➶

trips

"Enhancing the Freeze-Thaw Durability of Concrete through Ice Recrystallization Inhibition by Poly(vinyl alcohol)."

32548466

Poly(p-phenylenevinylene) macromolecule affects NFKBIA

| 1

Poly(p-phenylenevinylene) macromolecule inhibits NFKBIA. 1 / 1

| 1

---

➶

eidos

"PPV induces the degradation of IkappaBalpha gene expression Since the degradation of IkappaBalpha will release the NF-kappaB , the level of IkappaBalpha expression was also confirmed following transfection with 4 mug of pEGFP-N1-NS1 ."

32476323

Poly(cytidylic acid) affects RELA

| 1

Poly(cytidylic acid) inhibits RELA. 1 / 1

| 1

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➶

reach

"It is not clear why no change in p65 translocation was observed here, but we have previously reported inhibition of p65 translocation by acute ethanol exposure in mice treated with polyinosinic polycytidylic acid to activate TLR3 [XREF_BIBR]."

19765273

Poly(cytidylic acid) affects IFNB1

| 1

Poly(cytidylic acid) inhibits IFNB1. 1 / 1

| 1

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➶

reach

"poly (rC), inhibited by greater than 95% the production of IFN-beta."

2177082

Poly(I:C) affects IRF3

| 1

Poly(I:C) inhibits IRF3. 1 / 1

| 1

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➶

medscan

"Knockdown of TLR3 disturbed poly(I:C)-induced suppression of c-Myc and upregulation of p-IRF3 in AS cells."

27183205

Poly IC affects IFIH1

| 1

Poly IC inhibits IFIH1. 1 / 1

| 1

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➶

reach

"DEC1 may serve as an anti-inflammatory factor by negative regulation of MDA5 and CXCL10 and RIG-I and CCL5 in human mesangial cells treated with poly IC."

28794402

Poly IC affects DDX58

| 1

Poly IC inhibits DDX58. 1 / 1

| 1

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➶

reach

"Knockdown of IFI35 resulted in a decrease of poly IC induced RIG-I and MDA5 protein as well as decreased CCL5 and CXCL10 mRNA and protein expression."

27639618

Poly I:C affects IRF7

| 1

Poly I:C inhibits IRF7. 1 / 1

| 1

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➶

reach

"A deficiency of PAR-1 was associated with significantly lower levels of poly I : C dependent induction of IFNbeta, IFNgamma, CXCL10, IRF7 and viperin but not CCL5 mRNA expression (XREF_FIG)."

27820939

Poly I affects IFNB1

| 1

Poly I inhibits IFNB1. 1 / 1

| 1

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➶

reach

"However, Alternaria significantly inhibited IP-10, I-TAC and IFN-beta production induced by viral double stranded RNA (dsRNA)-mimic poly I : C. TLR3 mRNA expression and protein production by poly I : C were significantly inhibited by Alternaria."

23711857

Plumbagin affects STAT2

| 1

Plumbagin inhibits STAT2. 1 / 1

| 1

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➶

reach

"Neither Prkce nor Stat3 are expressed in PTEN-P2 cells, but Prkca is in KM5, while several Stat family members, Stat1, 6, and 5a, are in KM15, which contains genes down-regulated by plumbagin, Stat5b is in KM28, which has a similar profile to KM5, and Stat2 (KM36) is down-regulated by plumbagin in the absence of DHT."

29426892

Plumbagin affects NFKBIA

| 1

Plumbagin inhibits NFKBIA. 1 / 1

| 1

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➶

sparser

"Next, plumbagin also strongly inhibited TPA-induced phosphorylation and degradation of inhibitor of kappaBalpha (IkappaBalpha), and the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun. Also, a dose-dependent inhibition on the binding abilities of NF-kappaB and activator protein-1 (AP-1) by plumbagin treatment was further observed."

19768635

Plumbagin affects NFKB1

| 1

Plumbagin inhibits NFKB1. 1 / 1

| 1

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➶

reach

"D. Plumbagin treatment indiscriminately inhibits the DNA binding activity of transcriptional factors AP-1, NFkB, and Stat3 in PCa cell lines."

18974148

Plumbagin affects JAK1

| 1

Plumbagin inhibits JAK1. 1 / 1

| 1

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➶

reach

"Plumbagin suppresses constitutive activation of JAK1 and JAK2."

20068065

Plumbagin affects CHUK

| 1

Plumbagin inhibits CHUK. 1 / 1

| 1

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➶

reach

"BT474 and SKBR3 cells with reduced IKKalpha and IKKbeta expression were treated with plumbagin (1 muM) for 24 h and the expression levels of MMP-9 were examined."

27727280

Platycodin D affects RELA

1 |

Platycodin D inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

23867902

Piroxicam affects JUN

| 1

Piroxicam inhibits JUN. 1 / 1

| 1

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➶

reach

"However, in the present study we found that both piroxicam, a general COX inhibitor, and NS-398, a COX-2 selective inhibitor, effectively suppressed the activation of transcription factor activator protein 1 (AP-1) induced by ultraviolet B (UVB) or 12-O-tetradecanoylphorbol-13-acetate in mouse epidermal JB6 cells."

12433932

Pirfenidone affects NLRP3

| 1

Pirfenidone inhibits NLRP3. 1 / 1

| 1

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reach

"Li et al. discovered that pirfenidone could inhibit the activation of NLRP3 inflammasome, which may be promising therapeutic strategy for ARDS."

| PMC

Pirfenidone affects JUN

| 1

Pirfenidone inhibits JUN. 1 / 1

| 1

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➶

reach

"Fig. 6B shows that pirfenidone did not inhibit phophorylation of ATF-2 and c- Jun in RAW264.7 cells."

12098600

Piperine affects MAPK14

| 1

Piperine inhibits MAPK14. 1 / 1

| 1

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➶

medscan

"Piperine inhibited IL-1β-induced p38 mitogen-activated protein kinase and STAT3 activation and, in turn, blocked the IL-1β-induced IL-6 expression."

25234193

Pioglitazone affects NLRP3

| 1

Pioglitazone inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Interestingly, pioglitazone reduced cerebral edema and immune response after TBI by downregulating the effects of NLRP3."

31561220

Pioglitazone affects NFKB1

| 1

Pioglitazone inhibits NFKB1. 1 / 1

| 1

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reach

"Wan et al. have shown that the PPAR gamma activator pioglitazone could attenuate caerulein induced p50 and p65 NF and kappaB dimer activity in the nucleus of caerulein treated AR42J cells [84]."

27282980

Pioglitazone affects MYD88

| 1

Pioglitazone inhibits MYD88. 1 / 1

| 1

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reach

"We did not see any changes in MyD88 expression when macrophages were treated with GW9662 only and prevented pioglitazone mediated MyD88 inhibition (XREF_SUPPLEMENTARY)."

24489087

Pioglitazone affects JUN

| 1

Pioglitazone inhibits JUN. 1 / 1

| 1

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reach

"Electrophoretic mobility shift assay identified that pioglitazone inhibited TGF-beta 1 induced DNA binding of activator protein-1 (AP-1)."

14693716

Pioglitazone affects IKBKB

| 1

Pioglitazone inhibits IKBKB. 1 / 1

| 1

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➶

reach

"In a HeLa cell NFkappaB regulated luciferase reporter system, some research have demonstrated that pioglitazone suppresses the reporter expression stimulated by the transfection and expression of the wide-type IKKbeta, and constitutively active IKKalpha and IKKbeta [18]."

18490130

Pioglitazone affects IFNB1

| 1

Pioglitazone inhibits IFNB1. 1 / 1

| 1

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➶

reach

"Interestingly, in addition to monocyte attracting chemokines, pioglitazone also decreased the initial release of IFN-beta by BM-DCs (XREF_FIG)."

22911155

Pioglitazone affects CHUK

| 1

Pioglitazone inhibits CHUK. 1 / 1

| 1

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➶

reach

"In a HeLa cell NFkappaB regulated luciferase reporter system, some research have demonstrated that pioglitazone suppresses the reporter expression stimulated by the transfection and expression of the wide-type IKKbeta, and constitutively active IKKalpha and IKKbeta [18]."

18490130

Picloram affects NFKBIA

| 1

Picloram inhibits NFKBIA. 1 / 1

| 1

---

➶

eidos

"Pathway stimulation triggers sequential phosphorylation , ubiquitination , and degradation of IkappaBalpha ."

32488146

Piceatannol affects TBK1

1 |

Piceatannol inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

Piceatannol affects RELA

| 1

Piceatannol inhibits RELA. 1 / 1

| 1

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➶

reach

"However, since other investigators have demonstrated that piceatannol can also block p65 dependent signaling pathways [17,18], and since the effects of IL-1B on p65 phosphorylation and chemokine expression were both prevented by piceatannol administration, we certainly believe that our current results do not contradict our previous findings."

22108531

Piceatannol affects NFKBIA

| 1

Piceatannol inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Piceatannol inhibited pSyk, CARD9 and pIkBalpha activation after 30 min of zymosan stimulation (XREF_FIG)."

22952831

Piceatannol affects MAP3K7

| 1

Piceatannol inhibits MAP3K7. 1 / 1

| 1

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➶

reach

"Both Piceatannol and iSyk prevented activation (phosphorylation) of both TAK1 and ERK."

27486461

Piceatannol affects JUN

| 1

Piceatannol inhibits JUN. 1 / 1

| 1

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➶

reach

"It can be seen in the Western blot analysis that resveratrol as well as piceatannol (curcumin-group) and BTB14431 as well as JFD02836 (emodin-group) induced a significant reduction of endogenous c-Jun in a dose dependent manner."

16083495

Piceatannol affects IKBKE

1 |

Piceatannol inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

Piceatannol affects CASP1

| 1

Piceatannol inhibits CASP1. 1 / 1

| 1

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➶

reach

"Correspondingly, piceatannol treatment also down-regulated caspase-1 activation and IL-1beta production (XREF_FIG)."

22496641

Phosphorothioate oligonucleotide affects TLR7

1 |

Phosphorothioate oligonucleotide inhibits TLR7. 1 / 1

1 |

---

➶

ctd

No evidence text available

27385120

Phosphoenolpyruvic acid affects PYCARD

| 1

Phosphoenolpyruvic acid inhibits PYCARD. 1 / 1

| 1

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➶

reach

"In the presence of GTP or phosphoenolpyruvate, theA -- ~-~ group had no significant effect relative to the basal (PNNP (aa -- 0) n.s., Table II), sug- gesting that GTP and phosphoenolpyruvate might block the weak ASC inhibi- tion."

6784766

Phosphatidylinositol phosphate affects MAPK8

| 1

Phosphatidylinositol phosphate inhibits MAPK8. 1 / 1

| 1

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➶

reach

"Ablation of PIP also abrogated serum induced activation of the downstream serine/threonine kinases AKT, ERK1/2, and JNK1."

23755096

Phosphatidyl-L-serine affects NLRP3

| 1

Phosphatidyl-L-serine inhibits NLRP3. 1 / 1

| 1

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➶

reach

"XREF_BIBR XREF_BIBR XREF_BIBR In accordance with these studies, we could confirm that PS expressing ectosomes suppress LPS priming of the NLRP3 inflammasome in vitro."

26245757

Phosphatidic acid affects RELA

| 1

Phosphatidic acid inhibits RELA. 1 / 1

| 1

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➶

reach

"In addition, an increased NF-kappaB and p65 level in the nucleus (Nuc) was detected in PA treated H9c2 cardiomyocytes, while TSG had the capacity for reduction of the PA induced up-regulation of NF-kappaB and p65 protein in the nucleus."

30820195

Phosphatidic acid affects NFKB1

| 1

Phosphatidic acid inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Schreck R, Grassmann R, Fleckenstein B and Baeuerle PA, Antioxidants selectively suppress activation of NF-KB by human T-cell leukemia virus Type I Tax protein."

7575657

Phosphate(3-) affects RIPK1

| 1

Phosphate(3-) inhibits RIPK1. 1 / 1

| 1

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➶

reach

"Addition of phosphate group on ser89 inhibits the activity of RIPK1; hence, this site is involved in regulation of RIPK1 activity during necroptosis."

29980212

Phorbol affects NLRP3

| 1

Phorbol inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Studies with vitamin D 3 plus phorbol ester transformed THP-1 macrophages demonstrated that functionalization, regardless of amount, corresponded with profoundly decreased NLRP3 inflammasome activation."

29370073

Phorbol affects NFKBIA

| 1

Phorbol inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Although IkappaBalpha degradation can be induced by phorbol ester alone, degradation of IkappaBbeta is largely dependent on the CD28 costimulatory signal."

8943328

Phorbol affects JUN

| 1

Phorbol inhibits JUN. 1 / 1

| 1

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➶

reach

"Our data further suggest that Trespin may inhibit the activation of c-Jun by phorbol esters through a MEKK1 and JNK independent mechanism.Our laboratory has recently identified a novel rat ov-serpin, Trespin, which is most highly expressed in adult lung, skin, and stomach, selectively forms heat- and SDS-stable complexes with plasmin and elastase, and inactivates plasmin."

12651162

Phorbol 12,13-dibutanoate affects NFKBIA

| 1

Phorbol 12,13-dibutanoate inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Treatment of BEND cells with rbIFN-tau also did not attenuate PDBu induced degradation of IkappaBalpha, suggesting that the IkappaBalpha and NFkappaB pathway is not a site of IFN-tau inhibition of PGF."

11207214

Phlorizin affects PYCARD

| 1

Phlorizin inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Phloridzin (100 microM) inhibited ASC uptake and inhibited the stimulatory effect of external ASC on 86Rb uptake."

9430555

Phloretin affects STAT1

| 1

Phloretin inhibits STAT1. 1 / 1

| 1

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➶

reach

"Furthermore, the dihydrochalcone aglycone phloretin and the dimeric flavan-3-ol procyanidin B (1) significantly inhibited proinflammatory gene expression and repressed NF-kappaB-, IP-10-, IL-8-promoter-, and STAT1 dependent signal transduction in a dose dependent manner."

19764067

Phloretin affects NLRP3

| 1

Phloretin inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Phloretin also inhibited the DSS induced (NOD)-like receptor family and pyrin domain containing 3 (NLRP3) inflammasome activations."

30604787

Phenylephrine affects NFKBIA

| 1

Phenylephrine inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Furthermore, treatment with phenylephrine induced IkappaBalpha degradation in an IKK dependent manner, suggesting that NF-kappaB is a downstream target of the hypertrophic agonists."

11381115

Phenyl-N-tert-butylnitrone affects RELA

1 |

Phenyl-N-tert-butylnitrone inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

14713331

Phenyl-N-tert-butylnitrone affects NFKB1

1 |

Phenyl-N-tert-butylnitrone inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

14713331

Phenyl isocyanate affects NFKBIA

| 1

Phenyl isocyanate inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"PIC signaled degradation of IkappaBalpha with the consequence of upregulating iNOS, TNF-alpha, and IL-1beta mRNAs and proteins."

15920723

Phenol affects RELA

| 1

Phenol inhibits RELA. 1 / 1

| 1

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➶

reach

"These results cumulatively indicate that tea polyphenol pretreatment could suppress the TLR4 and NF-kappaB p65 signaling pathway, protecting renal tubular epithelial cells against ischemia and reperfusion induced apoptosis, which implies that antioxidants may be a potential and effective agent for prevention of the ischemic and reperfusion injury through the suppression extrinsic apoptotic signal pathway induced by TLR4 and NF-kappaB p65 signal pathway."

24630969

Phenol affects PYCARD

| 1

Phenol inhibits PYCARD. 1 / 1

| 1

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➶

reach

"Phenol significantly reduced the ability of ASC to support hemopoiesis of granulocyte and monocyte precursors but no preferential effect between strains was evident."

4082195

Phenobarbital affects MAPK8

| 1

Phenobarbital inhibits MAPK8. 1 / 1

| 1

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➶

reach

"Hui et al. detected high levels of p-Jnk1 in human HCC lesions and found that the incidence of DEN and phenobarbital induced HCC was significantly reduced in Jnk1 -/- but not in Jnk2 -/- mice."

22340589

Phenethyl isothiocyanate affects STAT1

| 1

Phenethyl isothiocyanate inhibits STAT1. 1 / 1

| 1

---

➶

reach

"We had earlier reported a novel PEITC mediated attenuation of activated STAT1 in mouse cells XREF_BIBR."

23724058

Phenethyl isothiocyanate affects NFKBIA

| 1

Phenethyl isothiocyanate inhibits NFKBIA. 1 / 1

| 1

---

➶

medscan

"It has been reported that Phenylethyl isothiocyanate inhibits IκBα phosphorylation and decreases the nuclear translocation of p65 subunit of NF-κB; thus, based on this previous work and on the above-mentioned results, we propose that inhibition of IκBα degradation and suppression of NF-κB activity (by both IκBα association and dephosphorylation) could be mediated, at least in part, by PTPL1 and PKCδ, and that these signalling events contribute to apoptosis in PC3 prostate cancer cells."

23559010

Phenethyl isothiocyanate affects IRF3

| 1

Phenethyl isothiocyanate inhibits IRF3. 1 / 1

| 1

---

➶

reach

"We found that PEITC and ERU inhibited IRF3 mediated transcriptional activation of ISG56-promoter by p (I) :p (C), while SFN and ERY did not show significant changes (XREF_SUPPLEMENTARY)."

23509350

Phenethyl caffeate affects MAPK8

| 1

Phenethyl caffeate inhibits MAPK8. 1 / 1

| 1

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➶

reach

"In PC-3 cells, CAPE treatment increased protein expression level of phospho-JNK2 Tyr185, E-Cadherin, phospho-JNK1 Tyr185, ROR2, phospho-GSK-3a Ser21, GSK-3beta, but decreased abundance of phospho-Cdc42 and Rac1 Ser 71, nuclear Snail, nuclear beta-catenin, PLC-g II, Frizzled 5, JNK2, phospho-GSK-3beta Ser9, Cox-2, Dvl-3, Frizzled 4, vimentin, cytoplasmic Snail, and JNK1."

27191743

Phenethyl caffeate affects JUN

| 1

Phenethyl caffeate inhibits JUN. 1 / 1

| 1

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➶

reach

"CAPE at 0.1-5 muM concentrations attenuated both c-Fos and c-Jun translations significantly (P <.001) enhanced with RANKL."

29957360

Phenethyl caffeate affects IKBKB

| 1

Phenethyl caffeate inhibits IKBKB. 1 / 1

| 1

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➶

reach

"For inhibiting the IKKbeta/IkappaBalpha/NF-kappaB and JNK/AP -1 signal pathway, CAPE clearly diminished the activation of IKKbeta, IkappaBalpha (inhibitory proteins of NF-kappaB), and JNK through phosphorylation."

29957360

Phenazine-1-carboxylate affects TYK2

| 1

Phenazine-1-carboxylate inhibits TYK2. 1 / 1

| 1

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➶

reach

"PCA attenuated CXCR2 induction and the activation of Tyk2 and STAT1/3 in db/db mice."

22791342

Phenazine-1-carboxylate affects NLRP3

| 1

Phenazine-1-carboxylate inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In line with a requirement for ROS and RNS to inhibit NLRP3, 1-HP, and, to a lesser extent, PCA, but not phenazine, blocked the NLRP3 inflammasome."

29414783

Phenazine affects NLRP3

| 1

Phenazine inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In line with a requirement for ROS and RNS to inhibit NLRP3, 1-HP, and, to a lesser extent, PCA, but not phenazine, blocked the NLRP3 inflammasome."

29414783

Pevonedistat affects NFKB1

| 1

Pevonedistat inhibits NFKB1. 1 / 1

| 1

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➶

reach

"MLN4924 therefore inhibits also the betaTrCP dependent activation of the classical and the alternative NFkB pathway."

31406107

Pevonedistat affects ITCH

| 1

Pevonedistat inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Thus, it appears that MLN4924 downregulates c-FLIP independent of Itch."

21914854

Pevonedistat affects CHUK

| 1

Pevonedistat inhibits CHUK. 1 / 1

| 1

---

➶

reach

"Because MLN4924 inhibits the alternative NFkappaB pathway downstream of IKK1 at the level of p100 processing, the quite discordant effects between MLN4924 and BAY 11-7082 must thus be due to blockade of IKK1 mediated NFkappaB independent necrosis-inhibitory functions or represent an off-target effect of BAY 11-7082."

23527154

Permethrin affects FOS

| 1

Permethrin inhibits FOS. 1 / 1

| 1

---

➶

reach

"The membrane depolarization induced by elevating the potassium (K (+)) concentration in medium (high K (+)) caused the activation of c-fos and BDNF genes, which was also repressed by permethrin."

11082455

Peptide affects STING1

| 1

Peptide inhibits STING1. 1 / 1

| 1

---

➶

reach

"Influenza A virus interacts with STING through its conserved hemagglutinin fusion peptide (FP) to inhibits STING activation in response to membrane fusion [58]."

31419779

Peptide affects NFKB1

| 1

Peptide inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"] Leukoc Biol 2007; 82:801-810; LoiarroM, Sette C, Gallo G et al. Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-KB."

19065798

Peptide affects JUN

| 1

Peptide inhibits JUN bound to JNK. 1 / 1

| 1

---

➶

trips

"Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes."

12832416

Pentobarbital affects FOS

| 1

Pentobarbital inhibits FOS. 1 / 1

| 1

---

➶

reach

"As shown in Fig. 4, comparison of the numbers of c-Fos (+)-Trp (-) neurons in the DRN and MRN among all experimental groups revealed that pentobarbital induced (35 mg/kg, i.p.) significant reduction of c-Fos number especially at DRND (- 8.0 mm Bregma), DRNV (- 8.0 and - 8.5 mm Bregma) and DRNVL (- 8.0 mm Bregma), respectively."

21689675

Parthenolide affects TICAM1

| 1

Parthenolide inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"However, it is not known whether parthenolide inhibits the TRIF dependent pathway."

21347702

Parthenolide affects MAPK8

| 1

Parthenolide bound to histone deacetylase inhibitors inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"The NF-kappaB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7 and JNK1 dependent apoptosis in human acute myeloid leukaemia cells."

20701602

Parthenolide affects JAK1

| 1

Parthenolide inhibits JAK1. 1 / 1

| 1

---

➶

reach

"Parthenolide has been reported to inhibit JAK1 and STAT3 activity."

27594973

Paricalcitol affects STAT1

| 1

Paricalcitol inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Finally, paricalcitol also blocked ERK and STAT-1 activation in response to Aldo stimulation (XREF_FIG)."

26064952

Paricalcitol affects RELA

| 1

Paricalcitol inhibits RELA. 1 / 1

| 1

---

➶

reach

"Therefore, we wished to determine whether paricalcitol can prevent the LPS induced myocardial activation of p65 in vivo."

26954764

Parathion affects DDX58

| 1

Parathion inhibits DDX58. 1 / 1

| 1

---

➶

eidos

"It is currently undetermined whether such hybrids can sterically inhibit RIG-I due to the presence of mostly dNTPs or whether they inhibit RIG-I in a yet undescribed way ."

31379819

Paraquat affects RELA

| 1

Paraquat inhibits RELA. 1 / 1

| 1

---

➶

reach

"Chymostatin reversed the inflammatory effects of paraquat induced lung injury by inhibiting cathepsin G activity to up-regulate endocan expression and indirectly inhibit NF-kappaBp65 activity."

28940034

Paraquat affects NLRP3

| 1

Paraquat inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In conclusion, silymarin attenuated paraquat induced cytotoxicity in macrophage by inhibiting oxidative stress, NLRP3 inflammasome activation, cytokines secretion and apoptosis."

29054699

Paraquat affects JUN

1 |

Paraquat inhibits JUN. 1 / 1

1 |

---

➶

ctd

No evidence text available

17324951

Paraquat affects CASP1

1 |

Paraquat inhibits CASP1. 1 / 1

1 |

---

➶

ctd

No evidence text available

17561093

Paracetamol affects RELA

1 |

Paracetamol inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

18835260

Paracetamol affects NFKB1

| 1

Paracetamol inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Moreover, the toxicity of acetaminophen and of ozone is reduced in mice lacking a critical subunit of the active NF and kappaB complex (p52 or p50) demonstrating an involvement of this transcription factor family in tissue injury."

11246131

Palmitoleic acid affects RELA

| 1

Palmitoleic acid inhibits RELA. 1 / 1

| 1

---

➶

reach

"In hepatocytes, palmitoleate increased fat deposition, stimulated FAS expression, activated SREBP-1c, and decreased inflammation (NFkappaB p65 Ser 68, TNF-alpha, and IL-6) in both hepatocytes and RAW macrophages."

29065507

Paeoniflorin affects RELA

| 1

Paeoniflorin inhibits RELA. 1 / 1

| 1

---

➶

reach

"Furthermore, paeoniflorin attenuated the activity of nuclear factor-kappaB p65 unit, tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6, and reduced the COX-2 protein expression level."

26893662

Paeoniflorin affects NLRP3

| 1

Paeoniflorin inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In our study, paeoniflorin not only downregulated TLR4 but also suppressed the downstream inflammation related effectors NF-kappaB, NLRP3, caspase-1, and pro-IL-1beta."

29740218

Paeoniflorin affects CASP1

| 1

Paeoniflorin inhibits CASP1. 1 / 1

| 1

---

➶

reach

"In our study, paeoniflorin not only downregulated TLR4 but also suppressed the downstream inflammation related effectors NF-kappaB, NLRP3, caspase-1, and pro-IL-1beta."

29740218

Paclitaxel affects NFKB1

| 1

Paclitaxel inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Taxol treatment had a dramatic impact on this activity and blocked the poleward movement of p50 (dynamitin) at metaphase (XREF_FIG and Video 4)."

19029334

Paclitaxel affects FOS

| 1

Paclitaxel inhibits FOS. 1 / 1

| 1

---

➶

reach

"Taxol did not inhibit the induction of c-fos and c-myc genes by FBS or EGF stimulation."

1351422

P-cresol affects MAPK14

| 1

P-cresol inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"This study has demonstrated that p-cresol inhibits proliferation of endothelial progenitor cells via activation of p38 MAPK pathways."

21747198

Ozone affects NLRP3

| 1

Ozone inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Glyburide attenuates ozone induced pulmonary inflammation and injury by blocking the NLRP3 inflammasome."

32167222

Ozone affects NFKB1

| 1

Ozone inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Moreover, the toxicity of acetaminophen and of ozone is reduced in mice lacking a critical subunit of the active NF and kappaB complex (p52 or p50) demonstrating an involvement of this transcription factor family in tissue injury."

11246131

Oxidopamine affects JUN

| 1

Oxidopamine inhibits JUN. 1 / 1

| 1

---

➶

reach

"This notion is further supported by a related observation : when PBLs were exposed to toxin in combination with AMD, a mRNA inhibitor, there were a dramatic decreased in p53 nuclear translocation by those neurotoxins (e.g. 6-OHDA, Table 4) that coincides with low percentage of apoptotic index, whereas NF-kappaB and c-Jun were both moderately reduced by 6-OHDA, up-regulated by 5,6-DHT (only NF-kappaB) or left unchanged by 5,7-DHT."

11992635

Oxamate affects MAVS

| 1

Oxamate inhibits MAVS. 1 / 1

| 1

---

➶

reach

"Inhibition of lactate generation by oxamate potentiated MAVS mitochondria localization, but lactate add-back compromised this effect (XREF_FIG and XREF_FIG)."

31155231

Oxaloacetic acid affects RELA

| 1

Oxaloacetic acid inhibits RELA. 1 / 1

| 1

---

➶

reach

"As shown in XREF_FIG A, OAA treatment reduced the levels of the p65 subunit of the NF and kappaB complex and of the AP-1 component p-c-Fos in the TLR3 cascade activated by poly (I)."

31694243

Oxaliplatin affects STAT1

| 1

Oxaliplatin inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Notably, STAT1, NFKB1 and JUN are also targeted by irinotecan while fluorouracil targets NFKB1 and JUN and oxaliplatin targets JUN.."

26359356

Oxaliplatin affects NFKB1

| 1

Oxaliplatin inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Notably, STAT1, NFKB1 and JUN are also targeted by irinotecan while fluorouracil targets NFKB1 and JUN and oxaliplatin targets JUN.."

26359356

Oxaliplatin affects CHUK

| 1

Oxaliplatin inhibits CHUK. 1 / 1

| 1

---

➶

reach

"Encouragingly, the combination of ursolic acid and oxaliplatin remarkably inhibited p-ERK1/2, p-Akt, and p-IKKalpha, which was much more significant compared to those treated with ursolic acid or oxaliplatin alone."

27472952

Oxalic acid affects NLRP3

| 1

Oxalic acid inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"We propose that inhibiting oxalate induced inflammasome activation, or lowering plasma oxalate, may prevent or mitigate progressive renal damage in CKD, and warrants clinical trials."

27191349

Oxalic acid affects NFKBIA

| 1

Oxalic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"In addition, renal cell oxalate exposure promotes rapid degradation of IkappaBalpha, an endogenous inhibitor of the NF-kappaB transcription factor."

16284883

Oxalic acid affects JUN

| 1

Oxalic acid inhibits JUN. 1 / 1

| 1

---

➶

reach

"Treatment with mepacrine resulted in a 75 to 113% reduction of oxalate induced c-jun, egr-1, and c-myc mRNA, while AACOCF3 caused a 41 to 46% reduction of oxalate induced c-jun and egr-1 mRNA."

10916087

Osthole affects FOS

| 1

Osthole inhibits FOS. 1 / 1

| 1

---

➶

eidos

"In culture neurons treated with astrocyte-conditioned medium , osthole further reduce c-Fos expression , indicating osthole has a direct effect on neurons ."

32365053

Oseltamivir affects TLR7

| 1

Oseltamivir inhibits TLR7. 1 / 1

| 1

---

➶

reach

"Quercetin and oseltamivir increased cell viability and reduced the expression levels of TLR7 signal pathway."

22924574

Oroxylin A(1-) affects STAT1

| 1

Oroxylin A(1-) inhibits STAT1. 1 / 1

| 1

---

➶

reach

"This is consistent with the present findings that oroxylin A inhibition of STAT1 activation was accompanied by suppressing LPS induced expression of IL-1beta and IL-6 20 hours after LPS challenge."

23236370

Organometallic compound affects CASP1

1 |

Organometallic compound inhibits CASP1. 1 / 1

1 |

---

➶

ctd

No evidence text available

18571097

Omega interferon affects IFNAR2

1 |

Omega interferon inhibits IFNAR2. 1 / 1

1 |

---

➶

drugbank

No evidence text available

Omega interferon affects IFNAR1

1 |

Omega interferon inhibits IFNAR1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

Olmesartan affects MAPK14

| 1

Olmesartan inhibits MAPK14. 1 / 1

| 1

---

➶

reach

"Olmesartan based treatment decreased both high CSBP and morning HSBP in the PCH group to the same degree."

24766515

Oleoyl ethanolamide affects RELA

| 1

Oleoyl ethanolamide inhibits RELA. 1 / 1

| 1

---

➶

reach

"We previously reported that NOE significantly decreased NF-kappaB p65 DNA binding activity [XREF_BIBR]."

23357040

Oleic acid affects NLRP3

| 1

Oleic acid inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"One hypothesis could be that oleate and linoleate prevent NLRP3 inflammasome activation by binding these receptors, but with less affinity than omega-3FAs, explaining their lower efficiency."

25175736

Oleic acid affects NFKBIA

| 1

Oleic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"However, oleic acid did not prevent 10,12 CLA mediated activation of ERK, JNK, cJun, or IkappaBalpha or increased abundance of ATF3 (data not shown)."

22941440

Oleic acid affects JUN

| 1

Oleic acid inhibits JUN. 1 / 1

| 1

---

➶

reach

"Oleate treatment failed to decrease JNK and c-Jun overactivation (XREF_FIG), consistent with previous data that activation of this MAPK pathway occurred upstream of ATP depletion."

20578144

Oleic acid affects ITCH

| 1

Oleic acid inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Here we show that a naturally occurring monounsaturated fatty acid, oleic acid, inhibits TRPV1 activity, and also pain and itch responses in mice by interacting with the vanilloid (capsaicin)-binding pocket and promoting the stabilization of a closed state conformation."

27721373

Oleanolic acid affects RELA

| 1

Oleanolic acid inhibits RELA. 1 / 1

| 1

---

➶

reach

"Oleanolic acid intake at 0.1% and 0.2% suppressed NF-kappaB p65, Bax and cleaved caspase-3 production, and retained Bcl-2 expression (P < 0.05)."

22683839

Oleandrin affects STAT1

| 1

Oleandrin inhibits STAT1. 1 / 1

| 1

---

➶

eidos

"Other cardenolides digoxin , digitoxin , oleandrin , digitoxigenin , and digoxin-BSA also significantly downregulated JAK1 protein levels and STAT1 ( a , b ) and STAT3 phosphorylation ( a ) ."

| PMC

Okadaic acid affects RELA

| 1

Okadaic acid inhibits RELA. 1 / 1

| 1

---

➶

reach

"These findings suggested that OA suppressed the activation of p65 through the decreasing of p-IKKalpha and p-IkappaBalpha."

28472762

Okadaic acid affects NLRP3

| 1

Okadaic acid inhibits NLRP3. 1 / 1

| 1

---

➶

sparser

"In conclusion, our findings indicate that OA inhibits AII, K + and ACTH-induced stimulation of aldosterone secretion in bovine adrenal glomerulosa cells."

11948018

Okadaic acid affects MAPK8

| 1

Okadaic acid inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"We here demonstrate for the first time that OA and HT attenuate TNF-alpha-mediated JNK1 and JNK2 activation, pointing to JNK as a mediator of OA- and HT induced improvement in adiponectin expression and PPARgamma activity."

26030149

Okadaic acid affects JUN

| 1

Okadaic acid inhibits JUN. 1 / 1

| 1

---

➶

reach

"Sal or OA could suppress apoptosis via their antioxidant properties; mammalian target of rapamycin (mTOR), nuclear factor-kappaB (NF-kappaB), Jun N-terminal kinase (JNK), and mitogen activated protein kinase (MAPK) signaling pathways; inhibition of excessive Ca 2+ influx; and so on [XREF_BIBR - XREF_BIBR]."

28638431

Okadaic acid affects FOS

| 1

Okadaic acid inhibits FOS. 1 / 1

| 1

---

➶

reach

"Mechanistically, OA does not affect RANKL induced activation of theNF-kB, JNK, p38, ERK and Akt pathways, but inhibits the expression of the nuclear factor of activated T-cells c1 (NFATc1) and c-Fos."

29703642

Octanoic acid affects MAPK14

1 |

Octanoic acid inhibits MAPK14. 1 / 1

1 |

---

➶

ctd

No evidence text available

14984747

Nystatin affects MAPK14

| 1

Nystatin inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"The use of methyl-β-cyclodextrin and nystatin to disrupt lipid rafts prevents the clustering of Fas and the activation of CerS6 and p38 kinase, and also inhibits Stichoposide D-induced apoptosis."

26318294

Nucleoside triphosphate affects IFIH1

| 1

Nucleoside triphosphate inhibits IFIH1. 1 / 1

| 1

---

➶

sparser

"However, the molecular mechanism of helicase inhibition by free NTP is not known, and no structural data of free NTP-bound helicases are available."

27915293

Novobiocin(1-) affects EIF2AK1

| 1

Novobiocin(1-) inhibits EIF2AK1. 1 / 1

| 1

---

➶

reach

"The C-terminal Hsp90 inhibitors novobiocin (4) and coumermycin A1 (5) also inhibited the maturation / activation of HRI, but it was also apparent that incubation with these compounds reduced the quantity of [35 S] HRI that was present in the samples compared to the other Hsp90 inhibitors."

21486005

Nordihydroguaiaretic acid affects NFKB1

| 1

Nordihydroguaiaretic acid inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"NF-KB activation was also diminished in a dose dependent manner by NDGA, demonstrat- ing the importance of the PLA2-5-LOX pathway in the activation of NF-KB."

9065737

Nordihydroguaiaretic acid affects FOS

1 |

Nordihydroguaiaretic acid inhibits FOS. 1 / 1

1 |

---

➶

tas

No evidence text available

24831826

Noradrenaline affects RELA

| 1

Noradrenaline inhibits RELA. 1 / 1

| 1

---

➶

reach

"caused an increase in nuclear translocation of NF-kappaB p65, which was prevented by NE pre-treatment."

24304472

Noradrenaline affects NFKB1

| 1

Noradrenaline inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"In the sham ARVMs, the NE treatment produced a 46% decrease in NfKb and IkB ratio compared to the vehicle treated sham group."

19394424

Nogalamycin affects IFIH1

| 1

Nogalamycin inhibits IFIH1. 1 / 1

| 1

---

➶

sparser

"DNA-interacting compounds actinomycin, DAPI, daunorubicin, ethidium bromide, netropsin and nogalamycin were able to inhibit the helicase and ssDNA-dependent ATPase activity with apparent IC50 values ranging from 0.5 to 5.0 microM respectively."

18571876

Nocodazole affects NLRP3

| 1

Nocodazole inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Previous studies also demonstrated that microtubule polymerization is implicated in inflammasome activation, based on the finding that colchicine or nocodazole, an inhibitor of microtubule polymerization, clearly attenuated NLRP3 or pyrin inflammasome activation."

25601272

Nitrosobenzene affects IRF7

| 1

Nitrosobenzene inhibits IRF7. 1 / 1

| 1

---

➶

reach

"Furthermore, NOB alone could suppress TLR4/TRIF/IRF3 and TLR9 and IRF7 signaling pathways through the downregulation of their associated pathways (mRNA and related protein levels) and the release of IFN-alpha and IFN-beta compared to LPS or CpG-ODN stimulated PCa cells."

32048561

Nitroso group affects JAK1

| 1

Nitroso group inhibits JAK1. 1 / 1

| 1

---

➶

sparser

"Together these findings indicate that any inhibition of JAK1 by the acyloxy nitroso compounds does not result from a direct effect on the JH1 catalytic domain and does not adequately explain the inhibition of LIF-induced STAT3 tyrosine phosphorylation."

22905257

Nitroflurbiprofen affects RELA

1 |

Nitroflurbiprofen inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

12716482

Nitrocellulose affects MYD88

| 1

Nitrocellulose inhibits MYD88. 1 / 1

| 1

---

➶

reach

"The nitrocellulose membranes were blocked for 2 hours and incubated with 1:1000 rabbit polyclonal antihuman TLR4 (Abcam, Cambridge, UK), MyD88 (Cell signaling, USA), and mouse monoclonal antihuman beta-actin (Beyotime, Shanghai, China) overnight at 4degreesC."

26045709

Nitric oxide affects TYK2

| 1

Nitric oxide inhibits TYK2. 1 / 1

| 1

---

➶

reach

"Impaired up-regulation of SOCS3 could therefore also explain why IL-10 is not able to suppress nitric oxide production in Tyk2 deficient macrophages upon stimulation with IFN-gamma [XREF_BIBR]."

29016674

Nitric oxide affects TRAF6

| 1

Nitric oxide inhibits TRAF6. 1 / 1

| 1

---

➶

medscan

"The principal conclusion of these experiments is that Nitric oxide inhibits IL-1 receptor-associated kinase (IRAK) activity and attenuates the molecular interaction between tumor necrosis factor receptor-associated factor-6 and IRAK."

14679201

Nitric oxide affects TBK1

| 1

Nitric oxide inhibits TBK1. 1 / 1

| 1

---

➶

reach

"Furthermore, pTBK1, which was highly induced in the SAVI fibroblasts in response to cGAMP stimulation, was almost completely abolished by NO 2 -FA treatment (XREF_FIG)."

30061387

Nitric oxide affects PYCARD

| 1

Nitric oxide inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Indeed, we found that caspase-1-deficient macrophages stimulated with LPS plus ATP or nigericin formed ASC pyroptosomes normally (XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY) and that NO still inhibited the formation of the ASC pyroptosome in these cells."

23318584

Nitric oxide affects ITCH

| 1

Nitric oxide inhibits ITCH. 1 / 1

| 1

---

➶

reach

"The itch associated response of the NC mice was significantly suppressed by an intravenous injection of nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME, 10 mg/kg), but not D-NAME (10 mg/kg) and saline."

10629849

Nitric oxide affects IRF3

| 1

Nitric oxide inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Consistent with our hypothesis that dsRNA mediated induction of nitric oxide limits initiation of HSV-1 replication, inhibition of iNOS with either AMG or L-NIL partially (XREF_FIG) or fully (XREF_FIG) restored initiation of HSV-1 replication in WT or IRF3 -/- 9 -/- MEFs, respectively."

22363706

Nitric oxide affects IFNB1

| 1

Modified nitric oxide inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"In resting mouse peritoneal macrophages, constitutively released low levels of NO inhibited the expression of IFN-alpha 4 mRNA and, to a minor extent, of IFN-beta mRNA [31 *]."

10899033

Nintedanib affects TYK2

1 |

Nintedanib inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nintedanib affects TBK1

1 |

Nintedanib inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nintedanib affects RIPK1

1 |

Nintedanib inhibits RIPK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nintedanib affects MAPK8

1 |

Nintedanib inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nintedanib affects MAP3K7

1 |

Nintedanib inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nintedanib affects JAK1

1 |

Nintedanib inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nintedanib affects IKBKE

1 |

Nintedanib inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nintedanib esylate affects TYK2

1 |

Nintedanib esylate inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nintedanib esylate affects TBK1

1 |

Nintedanib esylate inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nintedanib esylate affects RIPK1

1 |

Nintedanib esylate inhibits RIPK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nintedanib esylate affects MAPK8

1 |

Nintedanib esylate inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nintedanib esylate affects MAP3K7

1 |

Nintedanib esylate inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nintedanib esylate affects JAK1

1 |

Nintedanib esylate inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nintedanib esylate affects IKBKE

1 |

Nintedanib esylate inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nimesulide affects IFNB1

1 |

Nimesulide inhibits IFNB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

22561872

Nilotinib affects MAPK8

1 |

Nilotinib inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Nilotinib affects IFNB1

| 1

Nilotinib inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"The inhibitor AMN107 inhibits IFN-beta production induced by poly (dA : dT), poly (I : C), and Sendai virus in THP-1 and mouse bone marrow derived macrophage cells."

30842273

Nigericin affects IFNB1

| 1

Nigericin inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Neither addition of nigericin nor monensin blocked the induction of ifnbeta; in fact, both resulted in the enhanced induction of ifnbeta (XREF_FIG C), while neutralizing the phagosomal pH as determined by Lyso-Tracker RED staining (unpublished data)."

17397264

Nifedipine affects TRIM25

| 1

Nifedipine inhibits TRIM25. 1 / 1

| 1

---

➶

reach

"Both verapamil and nifedipine suppressed EFP after a transient increase in repetition rate."

12480168

Nickel(2+) affects IKBKE

| 1

Nickel(2+) inhibits IKBKE. 1 / 1

| 1

---

➶

reach

"Nickel decreased interferon regulatory factor (IRF) 3 and IRF7, IKKepsilon, and Sp100."

21466819

Naringin affects NLRP3

| 1

Naringin inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Moreover, DSS induced the activation of mitogen activated protein kinase (MAPK) and (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome was inhibited by naringin."

30472831

Naringin affects JUN

| 1

Naringin inhibits JUN. 1 / 1

| 1

---

➶

reach

"In additional experiments, naringin reduced the transcriptional activity of activator protein-1 and nuclear factor kappaB (NF-kappaB), which are two important nuclear transcription factors that are involved in MMP-9 expression."

19810018

Naringin affects CASP1

| 1

Naringin inhibits CASP1. 1 / 1

| 1

---

➶

medscan

"Taken together, this study provides novel evidence that Naringin induces growth inhibition and apoptosis by inhibiting the nuclear factor κB/COX-2-caspase-1 pathway and that a positive interaction between nuclear factor κB and COX-2 pathway contributes to the growth and antiapoptotic effect in HeLa cells."

25174821

Myricetin affects STAT1

| 1

Myricetin inhibits STAT1. 1 / 1

| 1

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➶

reach

"Similarly, Cho et al. reported that myricetin suppressed IL-6 and other pro inflammatory mediators by activating NF-kappaB and STAT1 in LPS stimulated RAW 264.7 murine macrophages."

29071017

Myricetin affects RELA

| 1

Myricetin inhibits RELA. 1 / 1

| 1

---

➶

reach

"Myricetin Inhibited p65 Nuclei Translocation and Apoptosis in NRCM."

29147465

Myricetin affects CASP1

| 1

Myricetin inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Here we show through Michaelis-Menten kinetic analysis that myricetin as well other flavonoids are able to inhibit caspase-1, -3, or -7 activity in vitro and that the inhibition is competitive."

22140296

Mycophenolate mofetil affects RELA

| 1

Mycophenolate mofetil inhibits RELA. 1 / 1

| 1

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➶

reach

"DMF and MMF each inhibited TNFalpha induced nuclear accumulation of RelB, p65 and p50 in a dose dependent manner (XREF_FIG)."

21976775

Mycophenolate mofetil affects NFKB1

| 1

Mycophenolate mofetil inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"DMF and MMF each inhibited TNFalpha induced nuclear accumulation of RelB, p65 and p50 in a dose dependent manner (XREF_FIG)."

21976775

Morphine(1+) affects PYCARD

| 1

Morphine(1+) inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Morphine decreased ASC for IgG but increased ASC for IgM."

8768720

Morphine(1+) affects NLRP3

| 1

Morphine(1+) inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Our compound, procyanidins, as a ROS scavenger, significantly inhibited the morphine induced release of ROS and then suppressed the microglial NLRP3 inflammasome to attenuate morphine tolerance."

26931361

Morphine(1+) affects MAVS

| 1

Morphine(1+) inhibits MAVS. 1 / 1

| 1

---

➶

reach

"TABLE 3 ICs0 and maximum inhibitory effect of morphine in field stimulated visa deferentia isolated from chronically morphine treated mice."

6682043

Morphine(1+) affects MAP3K7

| 1

Morphine(1+) inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"Intrathecal administration of 5Z-7-oxozeaenol (OZ), a selective TAK1 inhibitor, attenuated the loss of morphine analgesic potency and morphine induced TAK1 up-regulation."

25625840

Morphine(1+) affects IRF7

| 1

Morphine(1+) inhibits IRF7. 1 / 1

| 1

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➶

reach

"The further experiments showed that morphine suppressed the expression of several key elements (RIG-I and IRF-7) in IFN signaling pathway."

22359571

Montelukast affects MAPK14

1 |

Montelukast inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

Montelukast sodium affects MAPK14

1 |

Montelukast sodium inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

Monocrotaline affects NLRP3

| 1

Monocrotaline inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Similarly, our study showed that the NLRP3 inflammasome was lower in rats receiving PNU-282987 therapy than rats treated with MCT alone."

30863307

Monensin A affects TANK

| 1

Monensin A inhibits TANK. 1 / 1

| 1

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➶

reach

"Monensin significantly decreased bulk tank MFP by 0.12 percentage points."

19164691

Monensin A affects NFKBIA

| 1

Monensin A inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Monensin did not induce significant degradation of IkappaB-alpha (XREF_SUPPLEMENTARY)."

28619997

Monensin A affects NFKB1

| 1

Monensin A inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Indeed, monensin and ammonium chloride blocked the activation of A-SMase and NF-KB."

7923351

Monensin A affects IFNB1

| 1

Monensin A inhibits IFNB1. 1 / 1

| 1

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➶

reach

"Neither addition of nigericin nor monensin blocked the induction of ifnbeta; in fact, both resulted in the enhanced induction of ifnbeta (XREF_FIG C), while neutralizing the phagosomal pH as determined by Lyso-Tracker RED staining (unpublished data)."

17397264

Momelotinib affects TBK1

| 1

Momelotinib inhibits TBK1. 1 / 1

| 1

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➶

sparser

"The multi-targeted kinase inhibitor momelotinib inhibits both JAK1/2 and the TBK1 (and IKKe) kinases."

29101114

Momelotinib affects CHUK

1 |

Momelotinib inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

Mixture affects IFNB1

| 1

Mixture inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Human Type I IFN Neutralizing Antibody Mixture that blocks the effect of IFN-β was included as a control."

31690057

Mitoxantrone affects NFKBIA

| 1

Mitoxantrone inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Mitoxantrone activated NFkappaB and stimulated IkappaBalpha degradation in the promyelocytic leukemia cell line HL60 but not in the variant cells, HL60 and MX2 cells, which lack the beta isoform of topoisomerase II and express a truncated alpha isoform that results in an altered subcellular distribution."

10940316

Mitomycin C affects NLRP3

| 1

Mitomycin C inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Further results indicated that MMC can inhibit the activation of the NLRP3 inflammatory signalling pathway and thus downregulate the expression of downstream molecules, including IL-18 and IL-1 beta."

31827916

Mithramycin affects RELA

| 1

Mithramycin inhibits RELA. 1 / 1

| 1

---

➶

reach

"Our data also showed that mithramycin A reduced p65 activity in Hep3Bx cells (XREF_SUPPLEMENTARY)."

26595522

Mithramycin affects JUN

| 1

Mithramycin inhibits JUN. 1 / 1

| 1

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➶

reach

"Mithramycin reduced neuronal upregulation of BH3-only proteins and mitochondrial dysfunction, attenuated caspase-3/7 activation and caspase substrates ' cleavage, and limited c-Jun activation."

32719328

Minocycline affects MAPK8

| 1

Minocycline inhibits MAPK8. 1 / 1

| 1

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➶

sparser

"Minocycline inhibited JNK1/2 and ERK1/2 but not p38 when stimulated by 2',3'-O-(4-benzoylbenzoyl)-adenosine 5'-triphosphate, indicating that minocycline affects only certain upstream signaling target(s) that are stimulus-specific."

16336636

Minocycline affects CHUK

| 1

Minocycline inhibits CHUK. 1 / 1

| 1

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➶

reach

"Moreover, intraperitoneal injection of minocycline (80 mg/kg) reversed BCP induced upregulation of NF-kappaB, p-IKKalpha and IkappaBalpha in spinal cord."

27157092

Mifepristone affects STAT1

| 1

Mifepristone inhibits STAT1. 1 / 1

| 1

---

➶

medscan

"Furthermore, treatment with RU486 inhibited the upregulation of STAT1 mediated by hGRβ."

26711253

Mevalonic acid affects IRF3

| 1

Mevalonic acid inhibits IRF3. 1 / 1

| 1

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➶

reach

"Infection with the attenuated VACV strain MVA activated IRF-3 via cGAS and STING, and accordingly STING dimerised and was phosphorylated during MVA infection."

29491158

Mevalonic acid affects CASP1

| 1

Mevalonic acid inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Our results, although preliminary, showed that the inhibition of the mevalonate pathway led to a hyper-expression of NALP3, suggesting a possible involvement of NALP3-inflammasome in the activation of caspase-1 consequent to GGPP decrement."

20179743

Metyrapone affects NFKB1

| 1

Metyrapone inhibits NFKB1. 1 / 1

| 1

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➶

reach

"The P450 inhi- bitor metyrapone and the cyclooxygenase inhibitor indo- n ' ~ ethacin slightly reduced NF-KB activation, but only at very high concentrations, (lanes 5,17)."

8772190

Methylphosphonate(2-) affects RELA

| 1

Methylphosphonate(2-) inhibits RELA. 1 / 1

| 1

---

➶

reach

"Finally, methylphosphonate oligomers targeted against c-myc mRNA inhibited production of c-myc p65 protein in peripheral and splenic lymphocytes, relative to a scrambled sequence oligomer, 4 hours after injection of a 300 nmol dose, as indicated by immunofluorescence of fixed cells stained with an anti-c-myc antiserum."

1841270

Methyllycaconitine affects MAPK8

| 1

Methyllycaconitine inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"Methyllycaconitine (100nM), an α7 nicotinic acetylcholine receptor antagonist, but not dihydro-β-erythroidine hydrobromide (20μM) blocked varenicline-stimulated migration and varenicline-activated ERK, p38 and JNK signaling in human umbilical vein endothelial cells."

28842382

Methyl affects RELA

| 1

Methyl inhibits RELA. 1 / 1

| 1

---

➶

sparser

"A relA mutant of S. typhimurium was inhibited by sulfometuron methyl on rich carbon sources that display a basal cyclic AMP level but not on poor carbon sources where the cyclic AMP concentration is elevated."

6090425

Methyl methanesulfonate affects NFKB1

| 1

Methyl methanesulfonate inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Our observations that genotoxic stress causes reduction in NFkB activity in MCF-7-p53off cells, while inactivation of all p53 family proteins leads to full insensitivity of NFkB activity to MMS incubation, indicate that p63 and p73 are fully responsible for MMS induced NFkB repression in absence of p53."

29107083

Methyl methacrylate affects JAK1

| 1

Methyl methacrylate inhibits JAK1. 1 / 1

| 1

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➶

reach

"We found in a DN thymus cell line (D1) that a low concentration of MMA +3 (50 nM) suppressed IL-7 dependent JAK1, 3 and STAT5 signaling."

26921788

Methyl isocyanate affects MAPK8

| 1

Methyl isocyanate inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"These findings suggest that methyl isocyanate inhibits angiogenesis by inducing ASK1-JNK-dependent endothelial cells death."

25068797

Methoxyfenozide affects RELA

| 1

Methoxyfenozide inhibits RELA. 1 / 1

| 1

---

➶

reach

"However, at the12 h exposure, the p65 was inhibited by both tebufenozide (60% inhibition) and methoxyfenozide (40% inhibition) treatments when compared to control."

12878229

Methotrexate affects ITCH

| 1

Methotrexate inhibits ITCH. 1 / 1

| 1

---

➶

reach

"XREF_BIBR, XREF_BIBR Finally, methotrexate decreased itch significantly in patients with primary biliary cirrhosis."

21767775

Methanol affects STAT1

| 1

Methanol inhibits STAT1. 1 / 1

| 1

---

➶

reach

"CJ methanol extract inhibited STAT1 activation in a concentration dependent manner."

23110456

Methanol affects JUN

| 1

Methanol inhibits JUN. 1 / 1

| 1

---

➶

reach

"The methanol extract of Ampelopsis radix reduced Jun and Foc retardation remarkably."

9568065

Methane affects MAVS

| 1

Methane inhibits MAVS. 1 / 1

| 1

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➶

reach

"Consistently, IFNβ induced the mRNA expression of antiviral-associated proteins such as Viperin, IRF7, PKR, MxA and MAVS, which was significantly inhibited by HPeV1 in A549 and T84 cells (Fig. 6C) ."

25646764

Methane affects IRF7

| 1

Methane inhibits IRF7. 1 / 1

| 1

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➶

reach

"Consistently, IFNβ induced the mRNAexpression of antiviral-associated proteins such as Viperin, IRF7, PKR, MxA andMAVS, which was significantly inhibited by HPeV1 in A549 and T84 cells (Fig. 6C)."

25646764

Methamphetamine affects FOS

| 1

Methamphetamine inhibits FOS. 1 / 1

| 1

---

➶

reach

"Aldolase C mRNA signals in Purkinje cells decreased only in lobules where methamphetamine induced c-fos signals were not reduced (lobules VI and IX)."

9889345

Metformin affects STAT1

| 1

Metformin inhibits STAT1. 1 / 1

| 1

---

➶

eidos

"Metformin reduced STAT1 activation in CD4 + T cells and prevented binding of pSTAT1 to MX1 and ISG15 gene promoters ."

31160534

Metformin affects NFKBIA

| 1

Metformin inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"In addition, metformin suppressed the transcription activity of NF-kappaB by inhibiting the degradation of IkappaBalpha."

30520054

Metformin affects MAPK8

| 1

Metformin inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"In HuH-7 cells, metformin and sorafenib effectively inhibited various species of MEK1/2, ERK1/2, JNK1 and AKT1."

27326258

Messenger RNA affects MAPK14

| 1

Messenger RNA inhibits MAPK14. 1 / 1

| 1

---

➶

trips

"Additionally, both EGF- and anisomycin-induced FGF-BP mRNA was abrogated by inhibition of p38 mitogen-activated protein kinase, demonstrating a role for p38 in the regulation of FGF-BP."

10753873

Messenger RNA affects IFIH1

| 1

Messenger RNA inhibits IFIH1. 1 / 1

| 1

---

➶

sparser

"Inhibition of TLR3, RIG-I and MDA5 by siRNA reduced innate cytokine mRNA, and increased rhinovirus replication."

21079690

Messenger RNA affects DDX58

| 1

Messenger RNA inhibits DDX58. 1 / 1

| 1

---

➶

sparser

"Inhibition of TLR3, RIG-I and MDA5 by siRNA reduced innate cytokine mRNA, and increased rhinovirus replication."

21079690

Messenger RNA affects CASP1

| 1

Messenger RNA inhibits CASP1. 1 / 1

| 1

---

➶

sparser

"Finally, AAV9-siRNA-caspase-1 was injected into the tail vein of APP/PS1 double transgenic mice (Alzheimer's disease mice) for caspase-1 mRNA inhibition, followed by observation of behavioural changes in mice and measurement of the expression of inflammatory factors and pyroptosis-related protein."

32521573

Meso-dihydroguaiaretic acid affects JUN

1 |

Meso-dihydroguaiaretic acid inhibits JUN. 1 / 1

1 |

---

➶

tas

No evidence text available

24831826

Meso-dihydroguaiaretic acid affects FOS

1 |

Meso-dihydroguaiaretic acid inhibits FOS. 1 / 1

1 |

---

➶

tas

No evidence text available

24831826

Mesalamine affects STAT1

| 1

Mesalamine inhibits phosphorylated STAT1. 1 / 1

| 1

---

➶

reach

"C3G and/or 5-ASA reduced the levels of cytokine induced phosphorylated STAT1 in the nucleus of HT-29 cells."

24039842

Mesalamine affects NFKBIA

| 1

Mesalamine inhibits NFKBIA. 1 / 1

| 1

---

➶

sparser

"The calycosin (50 mg/kg) and 5-ASA inhibited the phosphorylation of IKKα/β, IκBα and p65 to attenuate the inflammation, which was consistent with the suppression of mRNA expressions ( xref )."

29085602

Mesalamine affects NFKB1

| 1

Mesalamine inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Mesalazine also inhibits NF-KB activation and promote synthesis of phosphatidic acid (thus inhibit the stimulatory effects of ceramides on apoptosis)."

24215382

Mercury(2+) affects NLRP3

| 1

Mercury(2+) inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Mercury and arsenic attenuate canonical and non canonical NLRP3 inflammasome activation."

30209319

Mercury(0) affects EIF2AK1

1 |

Mercury(0) inhibits EIF2AK1. 1 / 1

1 |

---

➶

ctd

No evidence text available

17689536

Mercury dichloride affects NFKBIA

1 |

Mercury dichloride inhibits NFKBIA. 1 / 1

1 |

---

➶

ctd

No evidence text available

10748083

Mercaptopurine affects JUN

| 1

Mercaptopurine inhibits JUN. 1 / 1

| 1

---

➶

reach

"As shown in Fig. 6d, mercaptopurine and melatonin may synergistically block c-Jun signaling by targeting multiple cellular targets."

32194980

Mercaptoethanol affects MAPK8

1 |

Mercaptoethanol inhibits MAPK8. 1 / 1

1 |

---

➶

ctd

No evidence text available

10644709

Menatetrenone affects CASP1

| 1

Menatetrenone inhibits CASP1. 1 / 1

| 1

---

➶

reach

"MK-4 (5-20 mumol/L) significantly inhibited rotenone induced p38 activation, ROS production, and caspase-1 activation in BV2 cells."

27498777

Memantine affects STAT1

| 1

Memantine inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Mechanistically, memantine was found to attenuate the upregulation of the transcriptional factor interferon response factor-1 (IRF-1) induced by AGEs, as well as activation of the JAK2 and STAT1 pathway."

28545202

Melittin affects IKBKB

1 |

Melittin inhibits IKBKB. 1 / 1

1 |

---

➶

ctd

No evidence text available

17067557

Melittin affects CHUK

1 |

Melittin inhibits CHUK. 1 / 1

1 |

---

➶

ctd

No evidence text available

17067557

Melatonin affects TICAM1

| 1

Melatonin inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"Melatonin therapy attenuates the TLR4 signaling pathway in a MyD88- and TRIF dependent manner, dampening the inflammatory process induced by OC in a preclinical model of ovarian carcinogenesis."

25655081

Melatonin affects PYCARD

| 1

Melatonin inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Western blot analysis showed that the expressions of NLRP3 and ASC significantly increased following 15Gy irradiation, whereas melatonin treatment markedly attenuated the NLRP3 and ASC activations compared with those vehicle treated."

30755784

Melatonin affects MAPK8

| 1

Melatonin inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"Moreover, melatonin increased the phosphorylative activation of ERK 1/2 independently from the presence of UVB stress, and decreased the UVB-mediated activation of the stress kinases p38 MAPK and JNK."

18930812

Melatonin affects MAPK14

| 1

Melatonin inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Moreover, melatonin increased the phosphorylative activation of ERK 1/2 independently from the presence of UVB stress, and decreased the UVB-mediated activation of the stress kinases p38 MAPK and JNK."

18930812

Melatonin affects JUN

| 1

Melatonin inhibits JUN. 1 / 1

| 1

---

➶

reach

"As shown in Fig. 6d, mercaptopurine and melatonin may synergistically block c-Jun signaling by targeting multiple cellular targets."

32194980

Melatonin affects IFNB1

| 1

Melatonin inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Melatonin attenuated the increased levels of JAK2 and STAT1 activation as well as IFN-beta, and ZnPP reversed these inhibitory effects of melatonin."

22288937

Mastoparan-A affects RELA

| 1

Mastoparan-A inhibits RELA. 1 / 1

| 1

---

➶

reach

"Moreover, a combination of rapamycin (80 nM) and MPA (20 nM) inhibited the TNF-alpha-induced nuclear localization of NF-kappaB p65 in HaCaT cells when compared with individual drug treatments and other combinations of the two drugs."

25673929

Masoprocol affects FOS

1 |

Masoprocol inhibits FOS. 1 / 1

1 |

---

➶

tas

No evidence text available

24831826

Maslinic acid affects NFKBIA

| 1

Maslinic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

medscan

"Maslinic acid blocks TNFα-induced p65 nuclear translocation, p65 phosphorylation and IκBα degradation in pancreatic cancer cells. (A) Maslinic acid inhibited TNFα-induced p65 nuclear translocation by immunofluorescence analysis."

20367887

Maraviroc affects JAK1

| 1

Maraviroc inhibits JAK1. 1 / 1

| 1

---

➶

reach

"Importantly, CCR5 activated signaling proteins Janus Kinase 1 (JAK1), JAK2 and signal transducer and activator of transcription (STAT3) were inhibited by maraviroc."

28469959

Mannooligosaccharide affects RELA

| 1

Mannooligosaccharide inhibits RELA. 1 / 1

| 1

---

➶

reach

"Sow diet MOS decreased toll like receptor 2 (TLR2), TLR4 and interleukin 8 (IL-8) mRNA levels (P < 0.05) and tended to decrease nuclear factor-kappaB p65 (NF-kappaB p65) mRNA level (P = 0.07) in piglet intestinal lymphatic."

31603198

Manganese(II) chloride affects NFKBIA

1 |

Manganese(II) chloride inhibits NFKBIA. 1 / 1

1 |

---

➶

ctd

No evidence text available

18041089

Manganese(2+) affects RELA

| 1

Manganese(2+) inhibits RELA. 1 / 1

| 1

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➶

reach

"The results demonstrated that Mn deficiency significantly decreased the lysozyme and acid phosphatase (ACP) activities, up-regulated tumour necrosis factor alpha (TNF-alpha), interleukin 8 and the signalling factor nuclear factor-kappaB p65, and down-regulated interleukin 10 (IL-10), transforming growth factor beta1, inhibitor of signalling factors kappaB-alpha and target of rapamycin mRNA levels in the proximal intestine (PI), mid intestine (MI) and distal intestine (DI)."

26072140

Manganese(2+) affects NFKBIA

| 1

Manganese(2+) inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Results obtained revealed that Mn 2+ exposure (1.0 muM) to PC12 cells caused degradation of IkappaBalpha, within 5 min and completely degrades by 10 min and then reappeared at maximum by 30 min."

12425965

Malonaldehyde affects RELA

| 1

Malonaldehyde inhibits RELA. 1 / 1

| 1

---

➶

reach

"Our results demonstrated that ScB treatment reduced MDA level and increased SOD activity and attenuated plasma inflammatory cytokines expression and ScB administration also significantly reduced I/R induced activation of p38MAPK, ERK1/2, and NF-kappaB p65 but not JNK, indicating that the protective role of ScB in this skeletal I/R injury model might be partly mediated through inhibiting p38MAPK, ERK1/2, and NF-kappaB p65 pathways."

28706944

Maleic acid affects FOS

| 1

Maleic acid inhibits FOS. 1 / 1

| 1

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➶

reach

"Asenapine maleate, which could inhibit 5-HT1A, 1B, 2A, 2B, 2C, 5A, 6 and 7 [XREF_BIBR], also decreased TH or c-fos."

27144435

Magnesium(2+) affects NFKBIA

| 1

Magnesium(2+) inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"The present study was designed to test the hypothesis that administration of low extracellular levels of magnesium ions ([Mg (2+)] (o)) to primary cultured cerebral vascular smooth muscle cells will cause lipid peroxidation, degradation of IkappaB-alpha, and activation of nuclear transcription factor kappa B (NF-kappaB) in cultured cerebral vascular smooth muscle cells."

12697280

Magnesium(2+) affects JUN

| 1

Magnesium(2+) inhibits JUN. 1 / 1

| 1

---

➶

reach

"Magnesium lithospermate B mediates anti-inflammation targeting activator protein-1 and nuclear factor-kappa B signaling pathways in human peripheral T lymphocytes."

22569344

Magnesium oxide affects RELA

| 1

Magnesium oxide inhibits RELA. 1 / 1

| 1

---

➶

reach

"The EA.hy926 cells were then treated with cycloheximide (CHX) and MGO, as indicated in Figure XREF_FIG C, and the degradation of the p65 protein was facilitated by MGO treatment, indicating that MGO reduces the stability of the p65 protein."

28444875

Magnesium atom affects NFKBIA

| 1

Magnesium atom inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"More importantly, 3 mg/ mL of YPFS could induce the degradation of IkBa in a timedependent manner (0, 10, 20 and 30 min)."

24244327

Magnesium atom affects NFKB1

| 1

Magnesium atom inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"High [Mg (2+)] (o) (i.e. 4.8 mM) downregulated p50 and p65."

12697280

Magnesium atom affects IKBKB

| 1

Magnesium atom inhibits IKBKB. 1 / 1

| 1

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➶

reach

"Although several studies have shown that Mg 2+ / Mn 2+ -dependent protein phosphatase 1B (PPM1B) inactivated IKKbeta, few studies have investigated the role of PPM1B in denervated skeletal muscle."

22584641

MTOR inhibitor affects RIPK1

| 1

MTOR inhibitor inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"SPC212 and Mero-82 cells have a high autophagic flux and autophagy blockade sensitizes them to PI3K and mTOR inhibitors inducing cell death in a RIP1 dependent manner."

25950487

Lycorine affects NFKBIA

| 1

Lycorine inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"However, lycorine and glycyrrhizic acid administration significantly inhibited the accumulation of HMGB1, TLR4, TLR5, Myd88, P-P65, and P-IkappaBalpha in LPS treated cells."

32818131

Lycorine affects MYD88

| 1

Lycorine inhibits MYD88. 1 / 1

| 1

---

➶

reach

"However, lycorine and glycyrrhizic acid administration significantly inhibited the accumulation of HMGB1, TLR4, TLR5, Myd88, P-P65, and P-IkappaBalpha in LPS treated cells."

32818131

Lycorine affects JUN

| 1

Lycorine inhibits JUN. 1 / 1

| 1

---

➶

reach

"Treatment with lycorine significantly decreases p-FAK, p-Src, p-c-Jun, p-JNK and MMP2 in breast cancer cell lines, demonstrating the effect of lycorine in blocking matrix degradation through the Src/FAK signaling pathway to inhibit migration and invasion."

30114645

Lycopene affects MAPK8

| 1

Lycopene inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"In oxidative stress condition, lycopene inhibits extracellular stress signal pathway, such as p38 mitogen activated protein kinase, JNK, ATM, and p53, and regulates the expression of anti- and pro-apoptosis associated proteins."

26535076

Lycopene affects MAPK14

| 1

Lycopene inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"In oxidative stress condition, lycopene inhibits extracellular stress signal pathway, such as p38 mitogen activated protein kinase, JNK, ATM, and p53, and regulates the expression of anti- and pro-apoptosis associated proteins."

26535076

Lycopene affects JAK1

| 1

Lycopene inhibits JAK1. 1 / 1

| 1

---

➶

reach

"Lycopene treatment inhibits activation of Jak1 and Stat3 and Wnt and beta-catenin signaling and attenuates hyperproliferation in gastric epithelial cells."

30098838

Luteolin affects TICAM1

| 1

Luteolin inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"Additional studies showed that EGCG, luteolin and structural analogs of luteolin such as quercetin, chrysin, and eriodictyol, also inhibited TRIF signaling pathway by targeting TBK1 kinase [XREF_BIBR, XREF_BIBR]."

21631512

Luteolin affects TBK1

1 |

Luteolin inhibits TBK1. 1 / 1

1 |

---

➶

ctd

No evidence text available

19426678

Luteolin affects STAT1

| 1

Luteolin inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Together, these results suggest that luteolin suppresses NF-kappaB, STAT1 and IRF-1 signaling, thus attenuating inflammatory response of brain microglial cells."

21036586

Luteolin affects NLRP3

| 1

Luteolin inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Quercetin, luteolin and EGCG reduced reactive oxygen species production and inhibited TXNIP and NLRP3 inflammasome activation, lead to the downregulation of IL-1beta expression."

25446924

Luteolin affects NFKB1

| 1

Luteolin inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Kao et al. found that luteolin decreased the LPS and IFN-gamma-induced nuclear accumulation of p65 and Rel B but not p50, suggesting partial inhibition of NF-kappaB activation in BV-2 microglial cells (Kao et al., 2011)."

29801717

Luteolin affects FOS

1 |

Luteolin inhibits FOS. 1 / 1

1 |

---

➶

ctd

No evidence text available

16343431

Luteolin affects DDX58

| 1

Luteolin inhibits DDX58. 1 / 1

| 1

---

➶

reach

"In addition, luteolin has been shown to inhibit the kinase activity of TBK [XREF_BIBR] a component of the RIG-I cascade."

28709400

Luteolin affects CASP1

| 1

Luteolin inhibits CASP1. 1 / 1

| 1

---

➶

reach

"The results clearly demonstrate that the naturally derived compounds, quadrangularin and luteolin potentially inhibit ROCK2 and Caspase-1 with high binding affinity, and showed stable conformation throughout simulation trajectory period."

31714189

Lovastatin affects JUN

| 1

Lovastatin inhibits JUN. 1 / 1

| 1

---

➶

medscan

"Lovastatin impaired the binding of the transcription factors c-Jun and Sp1 to the MACC1 promoter, thereby inhibiting MACC1 transcription."

28570591

Lovastatin affects JAK1

1 |

Lovastatin inhibits JAK1. 1 / 1

1 |

---

➶

ctd

No evidence text available

17507688

Losartan affects MAPK14

| 1

Losartan inhibits MAPK14. 1 / 1

| 1

---

➶

reach

"The administration of losartan 50 mg (b.i.d) did not reduce the CSBP and there were insignificant changes in the AIx 75."

28197292

Losartan affects FOS

| 1

Losartan inhibits FOS. 1 / 1

| 1

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➶

reach

"Given that increased c-Fos immunoreactivity in the lamina terminalis following isoproterenol administration is abolished by the AT 1 receptor blocker losartan or the ACE inhibitor captopril it is recognized that circulating AngII is responsible for activation of the lamina terminalis after drug administration as opposed to vascular responses."

20092577

Lithium(1+) affects IFNAR1

| 1

Lithium(1+) inhibits IFNAR1. 1 / 1

| 1

---

➶

reach

"Unlike in Ifngr1 -/- mice, lithium delayed the onset (XREF_TABLE) and effectively attenuated EAE in Ifnar1 -/- mice (XREF_FIG)."

23285134

Lithium chloride affects NFKBIA

| 1

Lithium chloride inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Although IkappaBalpha and pP38 levels did not markedly change with Pam3CSK4 alone at the time points tested, LiCl pretreatment significantly enhanced IkappaBalpha degradation and pP38 levels."

23904208

Lithium chloride affects JUN

| 1

Lithium chloride inhibits JUN. 1 / 1

| 1

---

➶

reach

"To confirm the mechanisms responsible for the GSK-3beta-dependent degradation of c-Jun, control shRNA and CD44 shRNA cells were treated with lithium chloride (LiCl), which inhibits GSK-3beta activity."

25979842

Lithium chloride affects FOS

| 1

Lithium chloride inhibits FOS. 1 / 1

| 1

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➶

reach

"LiCl induced c-Fos was significantly attenuated in the NTS, latPBN, PVN and CeA of AP lesioned rats, suggesting that these regions are dependent on AP activation."

21889521

Lisinopril affects MAP3K7

| 1

Lisinopril inhibits MAP3K7. 1 / 1

| 1

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➶

reach

"The quantity of p-TAK1 was also lower in the NIH 3T3 cells treated with lisinopril than in the blank control group, with or without TGF-beta1 stimulation."

29463869

Liraglutide affects PYCARD

| 1

Liraglutide inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Liraglutide (10-100nM) significantly inhibited ASC proliferation and viability, with a maximum effect at 6 days of culture (45% and 50%, for liraglutide 10 and 100nM, respectively); the effect was reverted by exendin 9-39."

25575456

Liraglutide affects CASP1

| 1

Liraglutide inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Our results found that liraglutide could reduce the NLRP3 inflammasome induced by HFD and decrease the IL-1beta secretion or caspase-1 and asc production in liver."

30269815

Lipoxin A4 affects MAPK14

| 1

Lipoxin A4 inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Lipoxin A4 suppresses the development of endometriosis in an ALX receptor-dependent manner via the p38 MAPK pathway."

24923883

Lipoxin A4 affects JUN

| 1

Lipoxin A4 inhibits JUN. 1 / 1

| 1

---

➶

reach

"Thus, lipoxin A4 inhibits neutrophil chemotaxis and adhesion, blocks calcium mobilization and phagocyte oxidase activity, inhibits nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) activation, and decreases inflammatory cytokine production and peroxynitrite generation."

18535486

Lipopolysaccharide affects TBK1

| 1

Lipopolysaccharide inhibits TBK1. 1 / 1

| 1

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➶

reach

"On the other hand, LPS treatment down-regulated IRF3, TBK1 and TRIF in 4F treated MDMs compared to vehicle pre-treatment."

22982462

Lipopolysaccharide affects TANK

| 1

Lipopolysaccharide inhibits TANK. 1 / 1

| 1

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➶

reach

"LPS stimulation decreased the electrophoretic mobility of TANK and OPTN (XREF_FIG)."

28159912

Lipopolysaccharide affects STAT2

| 1

Lipopolysaccharide inhibits STAT2. 1 / 1

| 1

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➶

reach

"Indeed, the up-regulation of IL-12p70 was inhibited in LPS stimulated Stat2 -/- cDCs (XREF_FIG) similarly to Ifnar -/- cDCs, as previously reported (XREF_FIG)."

27233962

Lipopolysaccharide affects RIPK1

| 1

Lipopolysaccharide inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"The LPS or bacterial induced necroptosis in wild type BMDMs was also inhibited by Necrostatin-1 (Nec-1), indicating a RIPK1 kinase dependency (XREF_SUPPLEMENTARY)."

27264187

Lipopolysaccharide affects JAK1

| 1

Lipopolysaccharide inhibits JAK1. 1 / 1

| 1

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➶

reach

"A causal link of decreased IFN-gamma signaling to SOCS3 induction was also suggested by the LPS dependent reduction of IFN-gamma-mediated Janus kinase 1 (JAK1) activation."

10453004

Lipopolysaccharide affects IRF7

| 1

Lipopolysaccharide inhibits IRF7. 1 / 1

| 1

---

➶

reach

"The critical importance of IRF mediated signaling to the neuroprotective process is shown clearly by the fact that mice lacking IRF3 or IRF7 fail to be protected or exhibit much reduced protection when treated with CpG, LPS or brief ischemia."

21653850

Lipopolysaccharide affects IKBKG

| 1

Lipopolysaccharide inhibits IKBKG. 1 / 1

| 1

---

➶

reach

"influenza infection and LPS induced septic shock by targeting NEMO for ubiquitination and degradation 29."

29581886

Lipopolysaccharide affects IFNAR1

| 1

Lipopolysaccharide inhibits IFNAR1. 1 / 1

| 1

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➶

reach

"Our studies showed that caspase-1 activation and IL-1beta production were reduced to the same extent in chronic LPS stimulated Ifnar -/- BMDMs (XREF_SUPPLEMENTARY)."

26412089

Lipid A(4-) (E. coli) affects NFKBIA

| 1

Lipid A(4-) (E. coli) inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Furthermore, lipid A induced SYK phosphorylation was abrogated in BCR deficient B cells, and ERK phosphorylation was reduced in the absence of either SYK or BCR, whereas lipid A induced IkappaBalpha degradation was not dependent on either SYK or BCR (XREF_FIG and XREF_FIG)."

28356391

Lipid A(4-) (E. coli) affects MYD88

| 1

Lipid A(4-) (E. coli) inhibits MYD88. 1 / 1

| 1

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➶

reach

"Other signaling inhibitors including antiapoptotic protein A20, agonistic lipid A and its analogues, inhibitors of IkB2, salicylate and parthenolide, NF-B kinases inhibitor PS-1145, inhibitors of p38, JNK, anti-TLR, anti-MyD88 antibodies, are able to target the TIR domain of the TLR4 or the MyD88 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

28373830

Lipid A(4-) (E. coli) affects IFNB1

| 1

Lipid A(4-) (E. coli) inhibits IFNB1. 1 / 1

| 1

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➶

reach

"Thus, BPI serves as an inhibitor against LBP to suppress the LPS and lipid A mediated activation of the IFN-beta promoter as well as NF-kappaB."

17239348

Linoleic acid affects NLRP3

| 1

Linoleic acid inhibits NLRP3. 1 / 1

| 1

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➶

reach

"One hypothesis could be that oleate and linoleate prevent NLRP3 inflammasome activation by binding these receptors, but with less affinity than omega-3FAs, explaining their lower efficiency."

25175736

Linezolid affects NLRP3

| 1

Linezolid inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Linezolid induced Nlrp3 inflammasome activation is independent of ROS but inhibited by mitochondrial stabilization with cyclosporine A. ROS generation has been suggested to be an absolute requirement for activation of the Nlrp3 inflammasome, and two recent studies have shown that this ROS is of mitochondrial origin."

23954133

Lincomycin affects TRIM25

| 1

Lincomycin inhibits TRIM25. 1 / 1

| 1

---

➶

reach

"Despite this cost in fitness, these mutants are not more susceptible to a wide range of antibiotics; including ribosome targeting antibiotics, such as lincomycin, chloramphenicol, and streptomycin, which have been shown previously to disrupt EF-P function in vitro."

23591475

Linalool affects CASP1

| 1

Linalool inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Endotoxin induced expression of toll like receptor 4 (TLR4), Myeloid differentiation primary response gene 88 (MyD88), myeloid differentiation protein 2 (MD2), Nod like receptor family, pyrin domain containing 3 (NLRP3), apoptosis associated speck like protein containing a caspase-recruitment domain (ASC), and caspase-1 in spleen and mesenteric lymph nodes (MLNs) were inhibited by all tested doses of cinnamaldehyde and linalool (P < 0.05)."

29389558

Linagliptin affects RELA

| 1

Linagliptin inhibits RELA. 1 / 1

| 1

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➶

reach

"Mechanistically, linagliptin potently suppresses TNF-alpha-induced accumulation of NF-kappaB nuclear protein p65 and activation of NF-kappaB promoter."

30466028

Ligand affects IFIH1

| 1

Ligand inhibits IFIH1. 1 / 1

| 1

---

➶

eidos

"Although the minimum length of MDA5 ligand remains unresolved , length-dependent induction of IFNs by ivt double-stranded ( ds ) RNA in RIG-I-deficient murine embryonic fibroblasts ( MEFs ) suggests that ligands as short as 100 bp can activate MDA5 [ 10 ] ."

30606502

Lidocaine affects STING1

| 1

Lidocaine inhibits STING1. 1 / 1

| 1

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➶

reach

"After injection of 30cc of 1% lidocaine with 1:100,000 epinephrine and 3cc of 8.4% bicarbonate to decrease the acidic sting of the local anesthetic, 30 minutes are allowed to elapse to let the epinephrine work."

| PMC

Lidocaine affects PYCARD

| 1

Lidocaine inhibits PYCARD. 1 / 1

| 1

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➶

reach

"Removing lidocaine from tumescent significantly reduced SVF and ASC apoptosis in the lipoaspirate."

27622097

Lidocaine affects FOS

| 1

Lidocaine inhibits FOS. 1 / 1

| 1

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➶

reach

"Lidocaine also downregulated c-Fos, which was implicated in pain transmission and morphine tolerance [XREF_BIBR]."

29096659

Levomethorphan affects RELA

| 1

Levomethorphan inhibits RELA. 1 / 1

| 1

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➶

reach

"In addition, compared with the SAP group, the expression level of HMGB1 was significantly decreased in the nucleus and the expression level of NF-kappaBp65 was significantly decreased in the cytoplasm from rats treated with DXM."

30365121

Levomethorphan affects NFKBIA

| 1

Levomethorphan inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"As shown in XREF_FIG, in LPS stimulated BMDCs, DXM treatment prevented downregulation of IkappaBalpha protein (XREF_FIG) and decreased NF-kappaB p65 nuclear localization (XREF_FIG)."

23781253

Leptomycin B affects NFKBIA

| 1

Leptomycin B inhibits NFKBIA. 1 / 1

| 1

---

➶

medscan

"These results indicated that Leptomycin B inhibits NF-κB activity by inducing the nuclear accumulation of IκBα, which then binds to NF-κB and inhibits its transcriptional activity."

20696864

Leptomycin B affects MAP3K7

| 1

Leptomycin B inhibits MAP3K7. 1 / 1

| 1

---

➶

medscan

"HEK293 was transfected with TRIM8, vector with or without p65, treated with Leptomycin B and nuclear factor kappa B activation measured by Dual Glo luciferase assay. (Lepto = Leptomycin B) (G) Leptomycin B suppresses TAK1 induced nuclear factor kappa B pathway."

23152791

Leptomycin B affects JUN

| 1

Leptomycin B inhibits JUN. 1 / 1

| 1

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➶

reach

"The decrease in the levels of c-Jun is almost complete when cells treated with LMB are kept in the presence of oxLDL."

29044181

Leptomycin B affects IFNB1

| 1

Leptomycin B inhibits IFNB1. 1 / 1

| 1

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➶

reach

"The infected cells were treated with DMSO (lanes 3, 5) or 10 μ M of LMB (lane 4) for another 3 h.GLTSCR2 attenuates IFN-β."

27824081

Leptomycin B affects FOS

| 1

Leptomycin B inhibits FOS. 1 / 1

| 1

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➶

reach

"The LMB treatment partially blocked the PD induced destabilization of c-Fos in the gp130 signals, but not in the TPA signals."

17018293

Lenalidomide affects IRF7

| 1

Lenalidomide inhibits IRF7. 1 / 1

| 1

---

➶

medscan

"In a cereblon-dependent fashion, lenalidomide downregulates IRF4 and SPIB, transcription factors that together prevent IFNβ production by repressing IRF7 and amplify prosurvival NF-κB signaling by transactivating CARD11."

22698399

Leflunomide affects JAK1

| 1

Leflunomide inhibits JAK1. 1 / 1

| 1

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➶

reach

"Prior studies suggest that A77 1726, the active metabolite of leflunomide, inhibits the activity of JAK1 and JAK3."

32598086

Leflunomide affects CASP1

| 1

Leflunomide inhibits CASP1. 1 / 1

| 1

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➶

reach

"Moreover, inhibitors of STAT6, specifically Leflunomide or JAK Inhibitor I (JAKI), blocked the suppression of active caspase-1 activity by IL-4 and IL-13."

26091108

Lead atom affects NFKB1

| 1

Lead atom inhibits NFKB1. 1 / 1

| 1

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➶

reach

"However, PBN inhibits NFkB, inducible nitric oxide synthase, inducible cyclooxygenase (COX) 2, and proinflammatory cytokines, suggesting that PBN also has antiinflammatory actions under certain conditions (Kotake et al., 1998; Sang et al., 1999)."

11074300

Lead atom affects ITCH

| 1

Lead atom inhibits ITCH. 1 / 1

| 1

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➶

reach

"(D-E) Systemic administration of PBN (10-300 mg/kg; i.p.) and EGCG (50-200 mg/kg; i.p.) dose-dependently attenuated CQ induced itch in mice (C, F) Local administration of EGCG (50-200 mug; i.p.) dose-dependently attenuated 48/80 and CQ induced itch in mice."

29402411

Lead atom affects EIF2AK1

1 |

Lead atom inhibits EIF2AK1. 1 / 1

1 |

---

➶

ctd

No evidence text available

17689536

Lawrencium atom affects RELA

| 1

Lawrencium atom inhibits RELA. 1 / 1

| 1

---

➶

reach

"Thus, the role of this complex in LR may be to prevent overactivation of p65, which could lead to a proinflammatory or proapoptotic phenotype and thus hinder proliferation, regeneration, and repair."

28474571

Latanoprost affects NFKBIA

| 1

Latanoprost inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"In this study, both latanoprost and bimatoprost were found to increase NF-kB and decrease IkappaBalpha."

27011234

Lapatinib affects STAT1

| 1

Lapatinib inhibits STAT1. 1 / 1

| 1

---

➶

medscan

"As shown in , lapatinib effectively inhibits EGFR activation, leading to a reduction in STAT1 expression."

22693070

Lapatinib affects NFKBIA

| 1

Lapatinib inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Since IkappaBalpha is also a downstream target gene of NF-kappaB, we hypothesized that lapatinib still can induce IkappaBalpha degradation but the protein level of IkappaBalpha was retained at a steady state in lapatinib treated clones due to de novo synthesis."

24216290

Lapatinib affects NFKB1

| 1

Lapatinib inhibits NFKB1. 1 / 1

| 1

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➶

reach

"54 Lapatinib on the other hand does not inhibit NFkB activation which may further contribute to its relative cardiac sparing effect.Although the target is the same, clinical results with lapatinib indicate its minimal cardiac toxicity."

19640652

Lapatinib affects IKBKG

| 1

Lapatinib inhibits IKBKG. 1 / 1

| 1

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➶

reach

"Lapatinib Treatment Prevents Biliary Expansion and Ducto and Cystogenesis in NEMO incrementhepa / JNK Deltahepa Mice."

32490320

Lanosterol affects IFNB1

| 1

Lanosterol inhibits IFNB1. 1 / 1

| 1

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➶

reach

"Lanosterol accumulation in macrophages, because of either treatment with ketoconazole or induced conditional disruption of Cyp51A1 in mouse macrophages invitro, decreases IFNbeta mediated signal transducer and activator of transcription (STAT) 1-STAT2 activation and IFNbeta stimulated gene expression."

28658622

Lactose affects RELA

| 1

Lactose inhibits RELA. 1 / 1

| 1

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➶

reach

"These results indicate that lactose suppresses ERK1/2 and NF-kappaB p65 signaling, leading to inhibition of cytokine production in pancreatic acinar cells."

29719535

Lactate affects NFKBIA

| 1

Lactate inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"In addition, in endothelial cells, lactate was shown to activate the NFkappaB dependent IL-8 transcription by inducing degradation of IkappaBalpha [XREF_BIBR]."

25790431

Lactate affects IFNB1

| 1

Lactate inhibits IFNB1. 1 / 1

| 1

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➶

reach

"Moreover, lactate addition in Ldha -/- macrophage consistently reduced IFN-beta production (XREF_FIG)."

31155231

Lactacystin affects TRAF3

| 1

Lactacystin inhibits TRAF3. 1 / 1

| 1

---

➶

medscan

"It was recently demonstrated that TRAF3 degradation in A549 cells is mediated by the E3 ligase, Triad3A, and is prevented by the proteasome inhibitors Lactacystin and MG132 ( )."

23303668

Labdane affects NFKBIA

| 1

Labdane inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"This labdane also suppressed constitutive NF-kappaB activity in different cell lines and inhibited IkappaBalpha kinase activation, thus leading to the suppression of IkappaBalpha phosphorylation, degradation, p65 nuclear translocation, and reporter gene transcription."

18852134

Labdane affects JUN

| 1

Labdane inhibits JUN. 1 / 1

| 1

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➶

reach

"The isolated labdane diterpenoid significantly inhibited c-Jun in the AP-1 pathway at 50 muM, indicating that inhibition of AP-1 is the mechanism by which the isolated compound exhibited its anti-inflammatory behaviour."

25705127

Kynurenine affects MYD88

| 1

Kynurenine inhibits MYD88. 1 / 1

| 1

---

➶

medscan

"Additionally, LXA4 and kynurenine suppress several proinflammatory genes in a suppressor of cytokine signaling2-dependent manner, which, consequently, blocks many inflammatory pathways including toll-like receptor/MyD88, toll-like receptor/TRIF, interleukin-1r/MyD88, and CD40/CD154 [ ]."

24527450

Kynurenic acid affects NLRP3

| 1

Kynurenic acid inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Kynurenic acid and GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress."

30790702

Ketone affects CASP1

| 1

Ketone inhibits CASP1. 1 / 1

| 1

---

➶

sparser

"Inhibition of interleukin-1beta converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones."

20674352

Ketone body affects NLRP3

| 1

Ketone body inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"The ketone body β-hydroxybutyrate (BHB)167 inhibits NLRP3 inflammasome-mediated inflammation by preventing K+ efflux."

32550001

Ketanserin affects FOS

| 1

Ketanserin inhibits FOS. 1 / 1

| 1

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➶

reach

"DOI (0.5 mg/kg) also induced c-Fos in the SCN and the induction was prevented by ritanserin and ketanserin."

9500663

Ketamine affects NFKB1

| 1

Ketamine inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"In conjunction with the last cited study, also using electrophoretic mobility shift assays, ketamine inhibited NFkB and another pro inflammatory transcription factor, activator protein 1 (AP-1) in human neutrophils and a leukocyte like transformed cell line, which was not dependent on activation of NMDA or opioid receptors."

24318540

Kamebakaurin affects NFKB1

1 |

Kamebakaurin inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

11877450

Kainic acid affects FOS

| 1

Kainic acid inhibits FOS. 1 / 1

| 1

---

➶

reach

"NMDA preconditioning and neuroprotection in vivo : delayed onset of kainic acid induced neurodegeneration and c-Fos attenuation in CA3a neurons."

19118538

Kaempferol oxoanion affects RIPK1

| 1

Kaempferol oxoanion inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"In addition, kaempferol pretreatment reduced propacetamol induced RIP1 and both JNK and ERK activations, subsequently ameliorating APAP induced cell death.To investigate whether administration of kaempferol can benefit APAP overdose patients, we first detected a suitable time point in mice mimicking the APAP overdose patients rescued by NAC with delay."

29574133

Kaempferol oxoanion affects RELA

| 1

Kaempferol oxoanion inhibits RELA. 1 / 1

| 1

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➶

reach

"XREF_BIBR Kaempferol inhibited tumor necrosis factor-alpha (TNF-alpha)-induced production of IL-6 and monocyte chemoattractant protein-1 (MCP-1) in MC3T3-E1 osteoblast like cells, and only kaempferol blocked TNF-alpha-induced trans-location of NF-kappaB subunit p65 from the cytoplasm to the nucleus."

29593412

Kaempferol oxoanion affects NLRP3

| 1

Kaempferol oxoanion inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In addition, withaferin A and kaempferol inhibit NLRP3 via indirect mechanisms."

| PMC

Kaempferol oxoanion affects JUN

| 1

Kaempferol oxoanion inhibits JUN. 1 / 1

| 1

---

➶

reach

"Further elucidation of the mechanism revealed that kaempferol treatment inhibited the activation of transcription factor activator protein-1 (AP-1) and MAPK signaling pathway."

25453494

Kaempferol oxoanion affects FOS

| 1

Kaempferol oxoanion inhibits FOS. 1 / 1

| 1

---

➶

reach

"In particular, c-Fos and phospho-cFos were dramatically inhibited by kaempferol."

29301320

Jnk-in-8 affects MAPK8

| 1

Jnk-in-8 inhibits MAPK8. 1 / 1

| 1

---

➶

sparser

"Importantly, our data strongly suggest that concomitant inhibition of JNK1 by JNK-IN-8 in the context of JNK2 C116S expression (and intact JNK2 signaling) contributes to tumor progression."

31063355

Ivermectin affects IRF3

| 1

Ivermectin inhibits IRF3. 1 / 1

| 1

---

➶

medscan

"Ivermectin treatment prevented the nuclear translocation of IRF3 after Sendai virus infection ( .)."

25763818

Itaconate(2-) affects IFNB1

| 1

Itaconate(2-) inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"This correlates with their immunosuppressive phenotype : dimethyl itaconate and 4-octyl itaconate inhibited IkappaBzeta and pro interleukin (IL)-1beta induction, as well as IL-6, IL-10 and interferon-beta secretion, in an NRF2 independent manner."

32694786

Isotretinoin affects STAT1

| 1

Isotretinoin inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Importantly, we showed that vitamin D treatment, as well as other compounds previously shown to ameliorate disease phenotype like farnesyltransferase inhibitors and rapamycin [XREF_BIBR], all-trans retinoic acid [XREF_BIBR, XREF_BIBR, XREF_BIBR], and remodelin [XREF_BIBR], markedly repress the STAT1 and IFN like response [XREF_BIBR]."

29637811

Isotretinoin affects MAVS

| 1

Isotretinoin inhibits MAVS. 1 / 1

| 1

---

➶

reach

"Moreover, nsp11 antagonizes type I IFN, specifically IFNbeta production, activated by the retinoic acid inducible gene 1 like receptor, showing substrate specificity toward Mitochondrial Antiviral Signaling proteins (MAVS) and RIG-I (transcripts and proteins), and demonstrating that this activity was associated to the endoribonuclease activity of this protein in which transfection mutant viruses were unable to degrade MAVS mRNA and impair IFNbeta production."

30842948

Isotretinoin affects IRF7

| 1

Isotretinoin inhibits IRF7. 1 / 1

| 1

---

➶

reach

"Knockdown of retinoic acid inducible gene-I inhibited the interferon-gamma-induced upregulation of interferon regulatory factor 7, a transcriptional factor involved in immune and inflammatory reactions."

20167631

Isorhamnetin affects CASP1

| 1

Isorhamnetin inhibits CASP1. 1 / 1

| 1

---

➶

reach

"In addition, EWD, isorhamnetin, and hyperoside inhibited caspase-1."

28160865

Isoquinoline affects IKBKB

| 1

Isoquinoline inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"The identification and progression of a potent and selective series of isoquinoline inhibitors of IkappaB kinase-beta (IKK-beta) are described."

19348415

Isoprenaline affects NFKBIA

| 1

Isoprenaline inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Ciccarelli and colleagues showed that genetic deletion of b2-adrenergic receptors impaired angiogenesis in a mouse model, and that isoproterenol induced IkappaBalpha degradation and enhanced NF-kB transcriptional activity in a time dependent manner [XREF_BIBR]."

27899953

Isoprenaline affects JUN

| 1

Isoprenaline inhibits JUN. 1 / 1

| 1

---

➶

reach

"miR-139-5p inhibits isoproterenol induced cardiac hypertrophy by targetting c-Jun."

29440459

Isoprenaline affects IFNB1

| 1

Isoprenaline inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"In this study we found that isoproterenol reduces T-cell proliferation and IFNgamma secretion in PBMCs cultures from healthy controls and IFNbeta treated but not untreated MS patients."

15342205

Isoliquiritigenin(1-) affects PYCARD

| 1

Isoliquiritigenin(1-) inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"XREF_BIBR, XREF_BIBR Isoliquiritigenin has been shown to inhibit ASC oligomerization and activation of the NLRP3 inflammasome in macrophages as well as inflammation in adipose tissue."

27607416

Isoliquiritigenin(1-) affects IRF3

| 1

Isoliquiritigenin(1-) inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Moreover, isoliquiritigenin was able to suppress TLR3 and TLR4 agonist induced IRF3 activations in RAW 264.7 macrophage cell line [XREF_BIBR]."

26785232

Isoliquiritigenin affects TBK1

| 1

Isoliquiritigenin inhibits TBK1. 1 / 1

| 1

---

➶

reach

"SHP-2, resveratrol isoliquiritigenin and glucocorticoid inhibit TBK1 kinase activity."

23395611

Isoliquiritigenin affects RELA

1 |

Isoliquiritigenin inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

15729620

Isoflurane affects NFKBIA

| 1

Isoflurane inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"In isoflurane + CsA treated rats at 6 h following treatment, the protein expression levels of IkappaBalpha increased significantly, whereas the expression levels of p-IkappaBalpha decreased significantly when compared with rats treated with isoflurane alone (P < 0.01; XREF_FIG)."

27909728

Isoflurane affects FOS

| 1

Isoflurane inhibits FOS. 1 / 1

| 1

---

➶

reach

"Isoflurane has been shown to decrease c-Fos activation in lumbar spinal cord after noxious electrical and mechanical stimulation to the hind paw."

24996127

Isoflavones affects RELA

1 |

Isoflavones inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

18640131

Isocyanic acid affects RELA

| 1

Isocyanic acid inhibits RELA. 1 / 1

| 1

---

➶

reach

"In addition, ICA intervention inhibited the up-regulation of NF-kappaB p65, Stat3, and c-Jun and down-regulation of IkappaBalpha in the inflammatory cell models."

29317219

Isocyanic acid affects NFKBIA

| 1

Isocyanic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"In addition, ICA intervention inhibited the up-regulation of NF-kappaB p65, Stat3, and c-Jun and down-regulation of IkappaBalpha in the inflammatory cell models."

29317219

Isocitrate(3-) affects NLRP3

| 1

Isocitrate(3-) inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Deletion of Salmonella aconitase, isocitrate lyase, or isocitrate dehydrogenase induces rapid NLRC4 independent NLRP3 inflammasome activation."

24638169

Iron(2+) affects STAT1

| 1

Iron(2+) inhibits STAT1. 1 / 1

| 1

---

➶

medscan

"Iron Supplementation Decreases STAT1 Phosphorylation in Splenic CD4+ T cells in FeD Mice."

25768944

Iron atom affects STAT1

| 1

Iron atom inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Iron Inhibited STAT1 Pathway in M1 Macrophages."

28286378

Iron atom affects RELA

| 1

Iron atom inhibits RELA. 1 / 1

| 1

---

➶

reach

"Our results show that iron overload induces NF-kappaB pathway activation in healthy human ESCs, which is reflected by events at 30 minutes of stimulus, like IkappaBalpha degradation, reduction of cytoplasmic p65, and its union to oligonucleotides with kappaB consensus sequence."

25500022

Iron atom affects JUN

| 1

Iron atom inhibits JUN. 1 / 1

| 1

---

➶

reach

"Additionally, iron dextran significantly decreased c-fos and c-jun and up-regulated cellular FLICE-inhibitory protein expression levels."

26059380

Iron atom affects FOS

| 1

Iron atom inhibits FOS. 1 / 1

| 1

---

➶

reach

"Additionally, iron dextran significantly decreased c-fos and c-jun and up-regulated cellular FLICE-inhibitory protein expression levels."

26059380

Irinotecan affects NLRP3

| 1

Irinotecan inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Ganciclovir reduces irinotecan induced intestinal toxicity by inhibiting NLRP3 activation."

31813002

Irbesartan affects JUN

| 1

Irbesartan inhibits JUN. 1 / 1

| 1

---

➶

sparser

"Thus, inhibition of FOS and JUN by Nadroparin and Irbesartan may have potential applications as anti-inflammatory options for RSV infection."

26760927

Irbesartan affects FOS

| 1

Irbesartan inhibits FOS. 1 / 1

| 1

---

➶

sparser

"Thus, inhibition of FOS and JUN by Nadroparin and Irbesartan may have potential applications as anti-inflammatory options for RSV infection."

26760927

Ionomycin affects IKBKB

| 1

Ionomycin inhibits IKBKB. 1 / 1

| 1

---

➶

medscan

"Furthermore, a dominant negative mutant of Akt abolishes IKKbeta inhibition by CaMKKc and ionomycin, suggesting that Akt acts as a mediator of calmodulin-dependent protein kinase kinase signaling to inhibit IL-1beta-induced IKK activity at an upstream target site."

11976320

Iodoquinol affects MAPK14

1 |

Iodoquinol inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

Iodonium affects IFNB1

| 1

Iodonium inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Addition of the antioxidant diphenylene iodonium (DPI) diminished DMXAA induced IFN-beta, but this decrease was independent of both the NADPH oxidase, Nox2, and de novo generation of reactive oxygen species."

23027866

Iodide affects FOS

| 1

Iodide inhibits FOS. 1 / 1

| 1

---

➶

reach

"Thus, iodide decreases the formation of Mod-1, an enhancer A complex involving the p50 subunit of NF-kappa B and a c-fos family member, fra-2, which was previously shown to be important in the suppression of class I levels by hydrocortisone."

9440807

Inositol affects NLRP3

| 1

Inositol inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Emerging evidence suggests the therapeutic potential for ameliorating MI induced myocardial damages by targeting NLRP3 and pyroptosis."

31645662

Inositol affects MYD88

| 1

Inositol inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Interestingly, MI induced cardiac hypertrophy was attenuated in MyD88 -/- mice [XREF_BIBR]."

24847766

Inositol affects JUN

| 1

Inositol inhibits JUN. 1 / 1

| 1

---

➶

reach

"Indeed, inositol hexaphosphate (InsP6) prevents activation of activator protein-1 (AP-1) and NF-kappaB as well as phosphorylation of extracellular signal regulated protein kinases (Erks) and c-Jun NH2-terminal kinases (JNKs) in response to UV-B, thereby avoiding UV-B-induced carcinogenesis."

27148278

Inositol affects FOS

| 1

Inositol inhibits FOS. 1 / 1

| 1

---

➶

reach

"Local disinhibition of MI elicited remarkably selective induction of c-Fos and JunB in enkephalinergic projection neurons."

9169535

Inhibitor affects IRF7

| 1

Inhibitor inhibits IRF7. 1 / 1

| 1

---

➶

eidos

"Further , the suppression of IRF7 activity by the use of an inhibitor , BAY11-7082 , could interfere with the development of ONFH while maintaining the therapeutic effect of corticosteroids [ 9 ] ."

31938894

Indometacin affects RELA

1 |

Indometacin inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

15579461

Indometacin affects NFKB1

1 |

Indometacin inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

15579461

Indole-3-methanol affects NFKBIA

| 1

Indole-3-methanol inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells."

15811958

Imperatorin affects JAK1

| 1

Imperatorin inhibits JAK1. 1 / 1

| 1

---

➶

reach

"Studies on alveolar macrophages also reveal that imperatorin reduced the production of pro inflammatory mediators and cytokines and inhibited pro inflammatory JAK1 and STAT3 and NF-kappaB signaling pathways."

30892032

Imperatorin affects CASP1

| 1

Imperatorin inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Distinct effects of imperatorin on allergic rhinitis : imperatorin inhibits caspase-1 activity in vivo and in vitro."

21730010

Imiquimod affects RIPK1

| 1

Imiquimod inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"Addition of GM-CSF and imiquimod, however, resulted in dominance of the pan HLA-DR-binding epitope specific response over the OVA specific CD4 T cell responses, decreased OVA specific CD8 T cell numbers and function in tolerant RIP OVA (LOW) mice, and failure to induce diabetes."

20861346

Imiquimod affects IFNB1

| 1

Imiquimod inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Disease suppression is associated with increased IFN-beta production in spleens of mice treated with imiquimod."

20138374

Imidazol-4-ylacetic acid affects MAVS

| 1

Imidazol-4-ylacetic acid inhibits MAVS. 1 / 1

| 1

---

➶

reach

"Use of IAA during sample preparation did not decrease the detection of MAVS oligomers in cells or plasma isolated from SLE patients (XREF_SUPPLEMENTARY)."

27899525

Imatinib affects NFKBIA

| 1

Imatinib inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"We have previously reported that Imatinib promoted IkappaB-alpha degradation in human islets XREF_BIBR."

21935477

Imatinib affects MAPK8

| 1

Imatinib inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"Next, we found that STI571 could attenuate TRAIL-induced c-Abl, JNK and p38 activation in HCT116 cells."

22462553

Imatinib affects JUN

| 1

Imatinib inhibits JUN. 1 / 1

| 1

---

➶

reach

"In addition, the c-Jun downregulation can be reversed by imatinib [XREF_BIBR]."

24422198

Imatinib affects IKBKB

| 1

Imatinib inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Aiming to investigate the SCF induced signaling in BMMCs we unexpectedly found that SCF induces IKK2 activation which was blocked by the c-Kit inhibitor imatinib."

26353931

Imatinib affects FOS

| 1

Imatinib inhibits FOS. 1 / 1

| 1

---

➶

reach

"Imatinib treatment rescued c-Fos and Dusp1 deleted mice from leukemia and led to rapid clearance of leukemic cells."

28319094

Imatinib affects CASP1

| 1

Imatinib inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Moreover, activated caspase-1 and caspase-3 were partially but significantly attenuated by the presence of imatinib in 32D/TetOff-p 210 cells."

30167087

Imatinib methanesulfonate affects RELA

1 |

Imatinib methanesulfonate inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

15100154

Imatinib methanesulfonate affects NFKB1

1 |

Imatinib methanesulfonate inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

15100154

Iloprost affects NFKBIA

| 1

Iloprost inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"PGE 2 and iloprost also inhibited disappearance of IkappaB-alpha from the cytosolic fraction and translocation of NF-kappaB subunits into the nuclear fraction."

9862429

Ifosfamide affects IFNB1

1 |

Ifosfamide inhibits IFNB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

15659795

Icosanoid affects CASP1

| 1

Icosanoid inhibits CASP1. 1 / 1

| 1

---

➶

sparser

"The eicosanoid does not directly modify or inactivate the caspase-1 enzyme."

25681332

Ibuprofen affects NFKB1

1 |

Ibuprofen inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

10602496

Ibrutinib affects NFKBIA

| 1

Ibrutinib inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"After TCR stimulation in primary CD4 + T cells and Jurkat T cells, Ibrutinib inhibited activation of PLCgamma1, NFAT, JunB and IKBalpha which are ITK downstream targets [XREF_BIBR]."

27917390

Ibrutinib affects NFKB1

| 1

Ibrutinib inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"As B-cell receptor (BCR) modulator, ibrutinib indirectly inhibits the classical NF-KB pathway."

27449094

Hypothemycin affects MAP3K7

1 |

Hypothemycin inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

26481152

Hypochlorous acid affects ITCH

| 1

Hypochlorous acid inhibits ITCH. 1 / 1

| 1

---

➶

reach

"High dose of hypochlorous acid and tofacitinib reduce lesions and itch in the murine NC/Nga model of AD."

29970189

Hypericin affects JUN

| 1

Hypericin inhibits JUN. 1 / 1

| 1

---

➶

reach

"For instance, the expression of ERCC1 can be modulated by redox sensitive transcription factor AP-1 (Li et al., 1999) which may be inhibited by hypericin according to a previous study (Bork et al., 1999)."

26673998

Hyperforin affects STAT1

| 1

Hyperforin inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Hyperforin, the non polyphenolic compound present in St. John 's wort, attenuates & beta;-cell death induced by interferon-& gamma; (IFN-& gamma;) by strongly down-regulating STAT1 activation."

20812906

Hydroxychloroquine affects NFKB1

| 1

Hydroxychloroquine inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"HCQ was able to decrease HCV core and NS5A proteins in a dose-dependent manner and gene expression analysis of transcriptional modulations showed that HCQ treatment strongly decreases the HCV-induced NFkB signaling, the endoplasmic reticulum stress, autophagic signaling and the p53 signaling pathways."

26013494

Hydroxychloroquine affects IKBKG

| 1

Hydroxychloroquine inhibits IKBKG. 1 / 1

| 1

---

➶

reach

"Hydroxychloroquine significantly reduces serum markers of endothelial injury and NEMO videocapillaroscopy score in systemic sclerosis."

30879061

Hydroxide affects TICAM1

| 1

Hydroxide inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"However, a high dose of dietary 25(OH)D 3 supplementation decreased TLR2, TLR9, MyD88, IL6, IL8, IFNλ1, STAT1, MxA, IFNAR1, and TRIF mRNA expression compared with CON-PEDV (Table 7 , p < 0.05)."

31470619

Hydroxide affects NFKB1

| 1

Hydroxide inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"1,25 (OH) 2 D 3 can also directly suppress RelB transcription [XREF_BIBR], as well as suppress the increase in p50 and its precursor, p105, and c-rel proteins [XREF_BIBR]."

21176770

Hydroxide affects IKBKG

| 1

Hydroxide inhibits IKBKG. 1 / 1

| 1

---

➶

reach

"In contrast, blocking NFkappaB signaling with a NEMO inhibitory peptide in cultures treated with 1,25 (OH) 2 D 3 did not affect OCL formation (data not shown)."

21195346

Hydroxide affects IFNB1

| 1

Hydroxide inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"The authors noted that 1alpha,25 (OH) 2 D treatment prior to or post-infection downregulated IL-6 and IL-8 RNA levels and decreased the levels of infection induced TNFalpha, IFNbeta, and ISG15."

30115864

Hydroxide affects IFNAR1

| 1

Hydroxide inhibits IFNAR1. 1 / 1

| 1

---

➶

reach

"However, a high dose of dietary 25(OH)D 3 supplementation decreased TLR2, TLR9, MyD88, IL6, IL8, IFNλ1, STAT1, MxA, IFNAR1, and TRIF mRNA expression compared with CON-PEDV (Table 7 , p < 0.05)."

31470619

Hydroquinone affects RELA

1 |

Hydroquinone inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

15894107

Hydroquinone affects NFKB1

1 |

Hydroquinone inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

15894107

Hydrogen sulfide affects RELA

| 1

Hydrogen sulfide inhibits RELA. 1 / 1

| 1

---

➶

reach

"The 16S rRNA level in the slow growing tufA499 strain was significantly reduced (to 44% of the wild-type level) but was restored back to the wild-type level in the strain carrying both tufA499 and inactivated relA (XREF_TABLE)."

24587376

Hydrogen sulfide affects NFKB1

| 1

Hydrogen sulfide inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"It would be interesting to study the fate of NFkB in this model; hydrogen sulfide could possibly inhibit NFkB, which would be a departure from the increase in its activity through sulfhydration induced by the gas in mice treated with TNFa."

24875544

Hydrogen sulfide affects IKBKB

| 1

Hydrogen sulfide inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"We showed that hydrogen sulfide (H2S) inhibited IKKbeta activation in the cell model of human PAEC inflammation induced by monocrotaline pyrrole stimulation or knockdown of cystathionine gamma-lyase (CSE), an H2S generating enzyme."

31654061

Hydrogen peroxide affects TRAF6

| 1

Hydrogen peroxide inhibits TRAF6. 1 / 1

| 1

---

➶

medscan

"Recruitment of NIK to TRAF6 following IL-1beta stimulation was inhibited by H2O2 clearance and Rac1 siRNA, suggesting that Rac-dependent NADPH oxidase may be a source of Reactive oxygen species required for NIK activation."

16286467

Hydrogen peroxide affects JUN

| 1

Hydrogen peroxide inhibits JUN. 1 / 1

| 1

---

➶

medscan

"Furthermore, in vitro EMSA analysis indicated the c-Jun binding was significantly decreased after H(2)O(2) exposure."

18556800

Hydrogen peroxide affects ITCH

| 1

Hydrogen peroxide inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Furthermore, hydrogen peroxide induced itch was suppressed by TRPA1 antagonist and antioxidants such as vitamin E."

26351759

Hydrogen fluoride affects TBK1

| 1

Hydrogen fluoride inhibits TBK1. 1 / 1

| 1

---

➶

reach

"In addition, hydrogen fluoride suppresses enzymes in the Krebs cycle and Na/K + ATPase pump cells, which may result in cell death and cellular energy failure [XREF_BIBR]."

24472575

Hydrogen chloride affects RELA

| 1

Hydrogen chloride inhibits RELA. 1 / 1

| 1

---

➶

reach

"Among all synthesized compounds tested, we found that complex [Ni (H 2 L 1) (PPh 3)] Cl (5) (complex 5), potently inhibited IkappaBalpha degradation and NF-kappaB p65 nuclear translocation in LPS stimulated RAW264.7 cells as well as TNFalpha stimulated HeLa S3 cells."

24977407

Hydrogen chloride affects ITCH

| 1

Hydrogen chloride inhibits ITCH. 1 / 1

| 1

---

➶

reach

"14 A small pilot study in patients with pruritus from undefined etiologies demonstrated that topical application of hydrocortisone acetate 2.5% and pramoxine hydrochloride 1% in a hydrolipid lotion reduced pruritus by 30% from baseline as rated by patients using the visual analog scale within 24 hours of initiation of therapy."

21767774

Hydrogen chloride affects IFNB1

| 1

Hydrogen chloride inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"As shown in XREF_FIG, the CL RNA induced high levels of IFN-beta activation in RIG-I +/-, but not RIG-I -/- MEFs, and CIP treatment completely abolished the observed IFN-beta response."

24759703

Hyaluronic acid affects NFKBIA

| 1

Hyaluronic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"However, our in vivo study found that HA abolished the decrease in densitometric lung tissue cytoplasmic IkappaBalpha concentrations induced by HPV."

25924944

Hyaluronic acid affects MYD88

| 1

Hyaluronic acid inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Ozone- and fragmented HA induced airway hyper-responsiveness were also reduced in TLR4- and MyD88 deficient mice, leading to the conclusion that fragmented HA responses require TLR4 in vivo."

25926830

Hyaluronic acid affects JUN

| 1

Hyaluronic acid inhibits JUN. 1 / 1

| 1

---

➶

reach

"HA did not attenuate the LPS enhanced activation of activator protein-1."

12600832

Hyaluronan affects MYD88

| 1

Hyaluronan inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Low molecular weight hyaluronan promotes neutrophilia and abrogates lung allograft tolerance in a TLR2/4 and MyD88 dependent manner 25."

27861263

Humulone affects JUN

| 1

Humulone inhibits JUN. 1 / 1

| 1

---

➶

reach

"Humulone also diminished TPA induced DNA binding of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1)."

17372274

Humulone affects IKBKB

| 1

Humulone inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"An in vitro kinase assay revealed that humulone could directly inhibit the catalytic activity of IKKbeta."

17372274

Histamine affects STAT1

| 1

Histamine inhibits STAT1. 1 / 1

| 1

---

➶

reach

"XREF_BIBR Horr et al. have shown that histamine, by acting through the H4 receptors on T cells, can suppress STAT1 activation and help to drive the Th2 response, leading to the development of AD."

24069552

Histamine affects PYCARD

| 1

Histamine inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"In contrast, HSM reduced ASC and NLRP3 mRNAs in a statistically significant manner in the lungs of BLM treated mice when examined on day 21 (XREF_FIG)."

26497260

Histamine affects NLRP3

| 1

Histamine inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In contrast, HSM reduced ASC and NLRP3 mRNAs in a statistically significant manner in the lungs of BLM treated mice when examined on day 21 (XREF_FIG)."

26497260

Histamine affects NFKBIA

| 1

Histamine inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"At 10 min of histamine incubation, phosphorylation of IkappaBalpha was detected, which was also confirmed by slower migrating form of IkappaBalpha, and at 30 min, the amount of IkappaBalpha was reduced, indicating histamine induced degradation of IkappaBalpha."

15102074

Histamine affects MAPK14

| 1

Histamine inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"These data suggest that histamine can reduce local lamellipodia protrusion activity through activation of p38 mitogen-activated protein kinase."

25948734

Histamine affects FOS

| 1

Histamine inhibits FOS. 1 / 1

| 1

---

➶

reach

"The H1 histamine antagonist diphenhydramine, but not the H2 histamine antagonist cimetidine, reduced the amount of c-fos labeling."

8193936

Hexane affects JUN

| 1

Hexane inhibits JUN. 1 / 1

| 1

---

➶

reach

"Recently, Kim et al. [XREF_BIBR] reported that a hexane extract of aged black garlic (HEABG) potently suppressed the proliferation of tumor necrosis factor (TNF)-alpha-activated human endometrial stromal cells, through inhibiting the activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) transcription factors."

24741395

Hexadecanoic acid affects STING1

| 1

Hexadecanoic acid inhibits STING1. 1 / 1

| 1

---

➶

reach

"However, the only known viral antagonist that targets DNA-PK, C16, is dispensable for poxviruses to block STING activation (Georgana et al., 2018)."

30078703

Hexadecanoic acid affects MAPK8

| 1

Hexadecanoic acid inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"Concomitantly, palmitate ( ) and PKR silencing ( ) both decreased only the phosphorylation of Bcl-2 at Ser70, which lends support to the hypothesis that palmitate down-regulates the phosphorylation of Bcl-2 at Ser70 through PKR and JNK."

19259124

Hexadecane affects MYD88

| 1

Hexadecane inhibits MYD88. 1 / 1

| 1

---

➶

reach

"To investigate the effect of CNS specific disruption of MyD88 and subsequently that of IKK activation in the hypothalamus on peripheral glucose metabolism upon exposure to HFD, we next compared blood glucose and plasma insulin concentrations in control and MyD88 DeltaCNS mice."

19808018

Hexadecane affects MAPK8

| 1

Hexadecane inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"Importantly, this notion is further directly supported by our experiments, revealing that CNS specific disruption of JNK1 fails to improve diet induced leptin resistance."

19808018

Hexadecane affects IKBKB

| 1

Hexadecane inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Western blot analysis of protein extracts from mouse tissues demonstrated efficient CNS specific depletion of IKKbeta in nIKKbetaKO mice compared with control mice (XREF_FIG)."

20007573

Hexadecane affects IFNAR1

| 1

Hexadecane inhibits IFNAR1. 1 / 1

| 1

---

➶

reach

"To test this possibility, we used two types of knockout mice targeting IFNAR1, an IFN receptor subunit essential for IFN-alpha signal transduction : conditional CNS specific knockout mice and conventional knockout mice."

25068123

Hexadecan-1-ol affects JUN

| 1

Hexadecan-1-ol inhibits JUN. 1 / 1

| 1

---

➶

reach

"The inhibitory effects of SSd on PMA triggered T lymphocyte activation are associated with SSd induced downregulation of NF-kappaB, nuclear factor of activated T-cells, and activator protein-1 (c-Fos) signaling pathways."

29849917

Hexachlorophene affects MAPK14

1 |

Hexachlorophene inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

Heterocyclic compound affects RELA

1 |

Heterocyclic compound inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

26683377

Hesperidin affects NFKB1

| 1

Hesperidin inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Our microarray analysis also revealed that both orange juice and hesperidin upregulated the expression of the inhibitor of NFkB (NFkBIB)."

22110589

Hesperidin affects MAPK8

| 1

Hesperidin inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"Results from our study revealed that hesperidin suppressed both acetaldehyde-activated nuclear factor-kappaB and activator protein 1 activity by IkappaB, JNK, and p38 signaling pathways."

19110045

Hesperadin affects TYK2

1 |

Hesperadin inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

19035792

Heparin affects ITCH

| 1

Heparin inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Locally administered heparin, in a dose dependent manner, inhibited the flare, itch and wheal responses induced by intradermal injection of heat aggregated human IgG (HAGG)."

3733300

Hemin affects TRAF6

| 1

Hemin inhibits TRAF6. 1 / 1

| 1

---

➶

medscan

"Anti-osteoclastogenic properties of hemin were based on a down-regulation of c-fms, RANK, TRAF-6, and c-fos."

16234431

Hemin affects RELA

| 1

Hemin inhibits RELA. 1 / 1

| 1

---

➶

reach

"In the current study, hemin pretreatment reduced lung NF-kappaB p65 activation accompanied by reduced inflammation (reduced TNF-alpha, IL-6, and MPO) in the lung after OALT, Indicating that HO-1 induction attenuated post-OALT ALI by reducing inflammation in the lung."

26838179

Hemin affects PYCARD

| 1

Hemin inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Recently, Nurmi et al. found that intraperitoneal administration of a hemin derivative depleted ASC in mice macrophages, which was attributed to the autophagy pathway [XREF_BIBR]."

28219398

Hemin affects IFNB1

| 1

Hemin inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"At the transcriptional level, results obtained by run-on assays on nuclei from IFN treated cells indicate that hemin does not completely inhibit IFN-beta induction of 2-5A synthetase gene (s) at 6 h of treatment but abolishes it at 24 h."

7544231

Hemin affects FOS

| 1

Hemin inhibits FOS. 1 / 1

| 1

---

➶

medscan

"Anti-osteoclastogenic properties of hemin were based on a down-regulation of c-fms, RANK, TRAF-6, and c-fos."

16234431

Heme b affects STAT1

| 1

Heme b inhibits STAT1. 1 / 1

| 1

---

➶

medscan

"Atorvastatin increases expression of heme oxgenase-1 which inhibits activation of NFκB complex , STAT1 and expression of CXCL10 ( )."

23630573

Heme b affects EIF2AK1

| 1

Heme b inhibits EIF2AK1. 1 / 1

| 1

---

➶

medscan

"One of mammalian eIF-2alpha kinases is a heme-regulated inhibitor kinase , which is activated by heme deficiency and plays an important role in translational control."

11101152

Helenalin affects RELA

1 |

Helenalin inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

15930313

Haloperidol affects RIPK1

| 1

Haloperidol inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"According to our results of less inhibition of the JNK pathway, it was proposed that haloperidol may inhibit the RIP and IKK pathway, but this requires further investigation."

29849502

Haloperidol affects RELA

| 1

Haloperidol inhibits RELA. 1 / 1

| 1

---

➶

reach

"The present study showed that haloperidol suppressed IkappaBalpha degradation and p65 transactivation in TNF-alpha-activated THP-1 cells."

29849502

Haloperidol affects NFKB1

| 1

Haloperidol inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Haloperidol differentially modulates prepulse inhibition and p50 suppression in healthy humans stratified for low and high gating levels."

17460616

Haem affects EIF2AK1

| 1

Haem inhibits EIF2AK1. 1 / 1

| 1

---

➶

reach

"In mammalian cells there are at least four eIF2a kinases, including GCN2, PKR, PERK and HRI, which are activated by amino acid starvation, double stranded RNA, ER stress and haem depletion, respectively (Berlanga et al., 1999; Harding et al., 1999; Kaufman, 2000; Lu et al., 2001) ."

17490409

Guggulsterone affects TICAM1

| 1

Guggulsterone inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"However, it is not known whether guggulsterone inhibits the TRIF dependent pathway."

19000789

Guggulsterone affects RELA

| 1

Guggulsterone inhibits RELA. 1 / 1

| 1

---

➶

reach

"In addition, NF-kappaB p65 activation decreased significantly in cells treated with a combination of guggulsterone and gemcitabine when compared to treatment with gemcitabine alone."

22699931

Guanosine affects TLR7

| 1

Guanosine inhibits TLR7. 1 / 1

| 1

---

➶

medscan

"Accordingly, 2'-O-methylation of tRNA at a conserved guanosine in a dinucleotide motif abolishes TLR7 activation and N6-adenosine-methylation of bacterial 23s rRNA renders it inactive against TLR13 activation [ , - ]."

25785446

Guanosine affects NFKB1

| 1

Guanosine inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"We observed age dependent changes in glutamate uptake, glutamine synthetase (GS) activity, the glutathione (GSH) system, pro inflammatory cytokine (tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta)) release, and the transcriptional activity of nuclear factor kB (NFkB), which were prevented by guanosine in an HO-1-dependent manner."

27585449

Guanine affects NLRP3

| 1

Guanine inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Consistently, short-hairpin RNA dependent knockdown of BFA inhibited guanine nucleotide-exchange protein 1 (BIG1), a molecular target of BFA and an initiator of Golgi specific vesicle trafficking, abolished NLRP3 dependent apoptosis associated speck like protein containing a caspase-recruitment domain oligomerization and caspase-1 activation in BMDMs."

30592629

Guaiacol affects TRAF6

| 1

Guaiacol inhibits TRAF6. 1 / 1

| 1

---

➶

reach

"Therefore, the binding of RANKL to RANK stimulates recruitment of TRAF6, which is suppressed by guaiacol."

32185887

Guaiacol affects RELA

| 1

Guaiacol inhibits RELA. 1 / 1

| 1

---

➶

reach

"M-CSF and RANKL stimulation increased the nuclear translocation of p65, which was notably attenuated by guaiacol."

32185887

Goniothalamin affects MAP3K7

1 |

Goniothalamin inhibits MAP3K7. 1 / 1

1 |

---

➶

ctd

No evidence text available

23845509

Gold atom affects NFKBIA

| 1

Gold atom inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Only Au (III) activated IkappaBalpha degradation by itself."

15983993

Glycyrrhizinic acid affects NFKBIA

| 1

Glycyrrhizinic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"However, lycorine and glycyrrhizic acid administration significantly inhibited the accumulation of HMGB1, TLR4, TLR5, Myd88, P-P65, and P-IkappaBalpha in LPS treated cells."

32818131

Glycyrrhizinic acid affects MYD88

| 1

Glycyrrhizinic acid inhibits MYD88. 1 / 1

| 1

---

➶

reach

"However, lycorine and glycyrrhizic acid administration significantly inhibited the accumulation of HMGB1, TLR4, TLR5, Myd88, P-P65, and P-IkappaBalpha in LPS treated cells."

32818131

Glycyrrhizinate(3-) affects NFKB1

| 1

Glycyrrhizinate(3-) inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"While glycyrrhizin did not influence NFkB activity in non-infected A549 cells in the tested concentra-tions (data not shown), glycyrrhizin inhibited NFkB activation in H5N1-infected cells ( Figure 5A )."

21611183

Glycyrrhizinate(3-) affects IRF3

| 1

Glycyrrhizinate(3-) inhibits IRF3. 1 / 1

| 1

---

➶

reach

"However, glycyrrhizin did not inhibit NF-kappaB and IRF3 activation induced by MyD88 dependent (MyD88, IKKbeta) or TRIF dependent (TRIF, TBK1) downstream signaling components."

24462946

Glycyrrhizinate(3-) affects IFNB1

| 1

Glycyrrhizinate(3-) inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"In contrast, dipotassium glycyrrhizate (GK2), a soluble analogue of HMGB1-blocker Glycyrrhizin, down-regulated interferon-beta, a typical inflammatory cytokine induced by secreted HMGB1, and accelerated differentiation responses to the calcium treatment in these cells."

31916113

Glycine betaine affects RELA

1 |

Glycine betaine inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

25559852

Glyburide affects JUN

| 1

Glyburide inhibits JUN. 1 / 1

| 1

---

➶

reach

"Glibenclamide downregulated the activity of the JNK and c-jun apoptosis signaling pathway which, in turn, decreased apoptosis in endothelial cells (ECs)."

27297934

Glyburide affects FOS

| 1

Glyburide inhibits FOS. 1 / 1

| 1

---

➶

reach

"Glibenclamide also downregulated c-fos, which was implicated in pain transmission and morphine tolerance [XREF_BIBR]."

29178967

Glutathione affects MAPK14

| 1

Glutathione inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Pretreatment with antioxidants such as glutathione or estrogen attenuated TRAIL/Apo2L-induced apoptosis through a reduction of reactive oxygen species generation and diminished p38 mitogen-activated protein kinase and caspase activation."

11852102

Glutathione affects MAP3K7

| 1

Glutathione inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"Depleting glutathione did not potentiate the effects of TAK1 inhibition."

26114584

Glutathione affects IKBKB

1 |

Glutathione inhibits IKBKB. 1 / 1

1 |

---

➶

ctd

No evidence text available

17067557

Glutathione affects CHUK

1 |

Glutathione inhibits CHUK. 1 / 1

1 |

---

➶

ctd

No evidence text available

17067557

Glutathione disulfide affects RELA

1 |

Glutathione disulfide inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

12433058

Glutathione disulfide affects NFKB1

1 |

Glutathione disulfide inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

12433058

Glutamate(2-) affects IKBKG

| 1

Glutamate(2-) inhibits IKBKG. 1 / 1

| 1

---

➶

sparser

"Staurosporine and quinacrine were unable to prevent the inhibition of carbachol stimulated IP1 by glutamate."

7909933

Glucose affects TRAF3

| 1

Glucose inhibits TRAF3. 1 / 1

| 1

---

➶

reach

"Inhibition of glucose metabolism promoted death of TRAF3 deficient B cells."

27752131

Glucose affects PYCARD

| 1

Glucose inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"In vitro, recombinant human glial cell line derived neurotrophic factor (GDNF) prevented podocyte injury by high glucose similarly to ASC conditioned medium."

23844841

Glucose affects IRF3

| 1

Glucose inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Calcium disruption (as through the SERCA pump inhibitor thapsigargin) and oxygen glucose deprivation activate IRF3 through a STING dependent mechanism, whereas agents that disrupt N linked glycosylation (e.g., tunicamycin) appear to utilize a STING independent, but Site-1 and Site-2 protease (ATF6?)"

29556237

Glucose affects IKBKB

| 1

Glucose inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Interestingly, activation of AMP kinase was substantially more effective than cAMP signaling in suppressing high glucose induced IKKbeta activity, whereas both pathways were comparably active in suppressing the TNFalpha induced increase in IKKbeta."

17940218

Glucosamine affects NFKBIA

| 1

Glucosamine inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"We demonstrated that glucosamine treatment in cells reversed the depletion of I-kappaBalpha induced by TGase 2 (Figs. 2 and 3)."

18804908

Glucosamine affects NFKB1

| 1

Glucosamine inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"XREF_BIBR, XREF_BIBR Corroborating evidence has shown that glucosamine and chondroitin reduce factors downstream of NFkB, including : tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8), cyclooxygenase-2 (COX-2), and prostaglandin E 2 (PGE 2)."

27357024

Glucosamine affects JUN

| 1

Glucosamine inhibits JUN. 1 / 1

| 1

---

➶

reach

"Addition of glucosamine to rat chondrocytes treated with IL-1 beta or with ROS decreased the activation of the nuclear factor kappa B, but not the activator protein-1."

11801247

Glucocorticoid affects NFKBIA

| 1

Glucocorticoid inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"However, the inhibitory effects of GC upregulated IkappaBalpha, GILZ and MKP-1 on NF-kappaB signaling suggest that some of the more potent anti-inflammatory effects of GCs also involve transactivation."

26131974

Glucocorticoid affects MAP3K7

| 1

Glucocorticoid inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"We demonstrate that GC, a mainstay therapy for IBD, fails to suppress the activation of TAK1 and downstream signaling mediators that induce intestinal inflammation."

28373409

Glucocorticoid affects IFNB1

| 1

Glucocorticoid inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"During the early phase of glucocorticoid (GC)-induced osteoporosis (GIO), GC increases the expression of receptor activator of NF-kappaB ligand (RANKL) in bone forming cells and suppresses the production of interferon-beta in osteoclast progenitors, resulting in stimulation of bone resorption."

17079848

Glucocorticoid affects FOS

| 1

Glucocorticoid inhibits FOS. 1 / 1

| 1

---

➶

reach

"It was demonstrated that GC inhibit the assembly of c-Fos and c-Jun to form functional activator protein-1 [28]."

11306142

Gliotoxin affects RELA

1 |

Gliotoxin inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

14527959

Gliotoxin affects NFKB1

1 |

Gliotoxin inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

14527959

Ginsenoside Rg1 affects CASP1

| 1

Ginsenoside Rg1 inhibits CASP1. 1 / 1

| 1

---

➶

eidos

"Rg1 markedly reduced the symptoms and disease biomarkers in mice with ovalbumin-induced allergic rhinitis and also inhibited caspase-1 activation in the nasal mucosa tissue ."

32372859

Ginsenoside Rb3 affects JUN

| 1

Ginsenoside Rb3 inhibits JUN. 1 / 1

| 1

---

➶

reach

"Furthermore, ginsenoside Rb3 significantly attenuated the expression of mRNA of proto-oncogene c-myc, c-fos and c-jun."

20662827

Ginsenoside Rb3 affects FOS

| 1

Ginsenoside Rb3 inhibits FOS. 1 / 1

| 1

---

➶

reach

"Furthermore, ginsenoside Rb3 significantly attenuated the expression of mRNA of proto-oncogene c-myc, c-fos and c-jun."

20662827

Gentamycin affects RELA

1 |

Gentamycin inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

18694830

Genistein affects TYK2

| 1

Genistein inhibits TYK2. 1 / 1

| 1

---

➶

reach

"Genistein is a potent in vitro inhibitor of interferon alpha receptor activation of ISGF 3 [31], implying that the prolactin transactivation of lactoglobulin does not involve the p91 ISGF complex, and/or that genistein inhibits tyk 2."

8735588

Genistein affects NFKBIA

| 1

Genistein inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Moreover, genistein enhanced the IL-1alpha-dependent degradation of IkappaBalpha."

11737207

Genistein affects MYD88

| 1

Genistein inhibits MYD88. 1 / 1

| 1

---

➶

reach

"These data suggest that MyD88 upregulates autophagy, whereas Genistein reverses the effect of MyD88 siRNA on podocytes."

29999001

Genistein affects JAK1

| 1

Genistein inhibits JAK1. 1 / 1

| 1

---

➶

medscan

"For kinase inhibition, THP-1 cells were treated with genistein (100 µg/ml) (Sigma), PP1 (35 µM) (BioMol), the genistein analog daidzein (non-inhibitory, 100 µg/ml) (BioMol), a mixture of MAP kinase inhibitors SB203580 (p38 inhibitor) (BioMol) and PD98059 (p42/44 MEK) (Calbiochem) (20 µM each), the phosphatidylinositol 3 kinase inhibitor LY294002 (25 µM) (Calbiochem), the Bruton's tyrosine kinase (Btk) inhibitor LFM-A13 (100 µM) (Calbiochem), the Janus protein tyrosine kinase inhibitor (Janus protein tyrosine kinase inhibitor I) (100 nM) (Calbiochem), which inhibits JAK1, JAK2, and JAK3, on day 2 and again on day 3 during PMA-induced macrophage differentiation."

24143245

Genistein affects IKBKB

| 1

Genistein inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Genistein inhibited IKKbeta and nuclear factor-kB (NF-kB) activation with down-regulation of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) production and expression."

22901685

Genistein affects FOS

| 1

Genistein inhibits FOS. 1 / 1

| 1

---

➶

reach

"H-7 (50 microM) and genistein (100 microM) blocked c-fos induction as did PKC down-regulation with chronic treatment of phorbol 12-myristate 13-acetate."

7968349

Gemcitabine affects RELA

| 1

Gemcitabine inhibits RELA. 1 / 1

| 1

---

➶

reach

"In confirmation of the role of NF-kappaB, blocking of gemcitabine induced RelA nuclear translocation, decreases levels of MMP (metalloprotease)-2, MMP-9, VEGF, and IL-8, inhibiting angiogenesis and invasion [XREF_BIBR]."

26119834

Geldanamycin affects TBK1

| 1

Geldanamycin inhibits TBK1. 1 / 1

| 1

---

➶

medscan

"Treatment of 293 cells with geldanamycin interferes with the interaction of TBK1 and heat-shock protein of 90 kDa, resulting in TBK1 destabilization and its subsequent proteasome-mediated degradation."

16394098

Geldanamycin affects RIPK1

| 1

Geldanamycin inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"Geldanamycin (GA), an antitumor of benzoquinone ansamycin (Stebbins et al., 1997), is an HSP-90 inhibitor and induces RIP degradation, followed by inhibition of NF-kappaB-mediated protection (Lewis et al., 2000)."

12493534

Geldanamycin affects NLRP3

| 1

Geldanamycin inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"HSP90 is also essential for the activation of NLRP3 inflammasome, and geldanamycin (GA), a specific inhibitor of HSP90, blocks NLRP3 inflammasome activation and helps ameliorate NLRP3 inflammasome mediated diseases 35."

32312957

Geldanamycin affects MAVS

| 1

Geldanamycin inhibits MAVS. 1 / 1

| 1

---

➶

reach

"Taken together, these results suggest that geldanamycin and 17-AAG inhibit IRF3 activation by preventing MAVS aggregation on the mitochondria."

21782231

Geldanamycin affects MAP3K7

| 1

Geldanamycin inhibits MAP3K7. 1 / 1

| 1

---

➶

medscan

"The results showed that the specific inhibitor geldanamycin of Heat shock protein 90 dramatically inhibited IL-1beta stimulated TAK1-MAPKs and TAK1-nuclear factor-kappaB activation, resulting in the decrease of cyclooxygenase-2 (COX-2) protein expression."

18950863

Geldanamycin affects EIF2AK1

| 1

Geldanamycin inhibits EIF2AK1. 1 / 1

| 1

---

➶

reach

"Additionally geldanamycin inhibited the transformation of HRI into a stable heme-regulatable kinase."

9111082

Geldanamycin affects DDX58

| 1

Geldanamycin inhibits DDX58. 1 / 1

| 1

---

➶

medscan

"Treatment with geldanamycin prevented association between transfected RIG-I and HSP90 ( ) and significantly reduced the levels of endogenous RIG-I protein, in a time-dependent manner ( )."

19234166

Geldanamycin affects CHUK

| 1

Geldanamycin inhibits CHUK. 1 / 1

| 1

---

➶

reach

"The HSP90 inhibitor geldanamycin enhances the degradation of IKKalpha and blocks 3-Cl-AHPC activation of NF-kappaB and 3-Cl-AHPC-mediated apoptosis."

15930313

Gefitinib affects NFKBIA

| 1

Gefitinib inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Gefitinib combined with PDTC can inhibit P-IkappaBalpha production and NF-kappaB P-p50 and P-p65 activation to suppress the survival of residual H1650 cells and the generation of gefitinib resistant cells."

29891456

Gefitinib affects MAPK8

| 1

Gefitinib inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"It is clear from the data presented in XREF_FIG for the EGFSP genes, that gefitinib was unable to block the response of the EGFR, c-Fos, SOS, GRB2, JNK-1, MKK4 or RasGAP to luteolin."

20558290

Gefitinib affects FOS

| 1

Gefitinib inhibits FOS. 1 / 1

| 1

---

➶

reach

"It is clear from the data presented in XREF_FIG for the EGFSP genes, that gefitinib was unable to block the response of the EGFR, c-Fos, SOS, GRB2, JNK-1, MKK4 or RasGAP to luteolin."

20558290

Gastrin-17 affects RELA

1 |

Gastrin-17 inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

15623601

Gastrin-17 affects NFKB1

1 |

Gastrin-17 inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

15623601

Ganglioside affects IFNB1

| 1

Ganglioside inhibits IFNB1. 1 / 1

| 1

---

➶

sparser

"Inhibition of mouse fibroblast interferon by gangliosides."

6177531

Gamma-tocotrienol affects NLRP3

| 1

Gamma-tocotrienol inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Gamma-tocotrienol attenuates the aberrant lipid mediator production in NLRP3 inflammasome stimulated macrophages."

29957361

Gamma-tocotrienol affects JAK1

| 1

Gamma-tocotrienol inhibits JAK1. 1 / 1

| 1

---

➶

reach

"Gamma-Tocotrienol also inhibited the activation of Src, JAK1 and JAK2 implicated in STAT3 activation."

21198544

Gamma-tocotrienol affects CHUK

| 1

Gamma-tocotrienol inhibits CHUK. 1 / 1

| 1

---

➶

reach

"In addition, gamma-tocotrienol treatment caused a large decrease in NFkappaB transcriptional activity, apparently by suppressing IkappaB-kinase (IKK)-alpha/beta activation, an enzyme associated with inducing NFkappaB activation [XREF_BIBR]."

19954924

Gamma-aminobutyric acid affects NLRP3

| 1

Gamma-aminobutyric acid inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"This indicates that GABA A receptors are not necessary for ethanol to inhibit Nlrp3 inflammasome activation."

27421477

Gamma-aminobutyric acid affects FOS

| 1

Gamma-aminobutyric acid inhibits FOS. 1 / 1

| 1

---

➶

reach

"Injection of a GABA A agonist into the SCN of hamsters significantly inhibits phase delays and the induction of c-Fos when given just prior to a brief light pulse presented at CT13.5."

25865743

Gallic acid affects TICAM1

| 1

Gallic acid inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"Further, GA did not reduce proinflammatory cytokine secretion in TRIF deficient monocytes (XREF_FIG), providing further support that inhibition of TRIF dependent signaling is required for GA mediated reduction of proinflammatory cytokine secretion."

26601118

Gallic acid affects STING1

| 1

Gallic acid inhibits STING1. 1 / 1

| 1

---

➶

reach

"Both GA and 6-AN enhanced STING degradation compared to mock treated cells."

29241549

Gallic acid affects NLRP3

| 1

Gallic acid inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"HSP90 is also essential for the activation of NLRP3 inflammasome, and geldanamycin (GA), a specific inhibitor of HSP90, blocks NLRP3 inflammasome activation and helps ameliorate NLRP3 inflammasome mediated diseases 35."

32312957

Gallic acid affects NFKBIA

| 1

Gallic acid inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"The results showed that GA low-dose treatment markedly restrained the cytoplasm-nucleus translocation of NF-kappaB (p65) and increased IkappaBalpha expression but markedly inhibited the increment of p-IkappaBalpha in TP group."

28572827

Gallic acid affects NFKB1

| 1

Gallic acid inhibits NFKB1. 1 / 1

| 1

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➶

reach

"However, addition of GA after CDDP treatment could reverse this increase of p65 and p50 in the nucleus."

24300974

Gallic acid affects MAPK8

| 1

Gallic acid inhibits MAPK8. 1 / 1

| 1

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➶

reach

"Similar to the DMSO control, GA exhibited almost no effect on TNF induced JNK1 activation, even though the unstimulated JNK1 activity was slightly reduced by GA treatment."

11864612

Gallic acid affects MAP3K7

| 1

Gallic acid inhibits MAP3K7. 1 / 1

| 1

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➶

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"GA and RAD significantly reduces the stability of TAK1 through enhancing proteasome dependent degradation of TAK1."

18950863

Gallic acid affects FOS

| 1

Gallic acid inhibits FOS. 1 / 1

| 1

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➶

reach

"We firstly demonstrate that gallic acid can transcriptionally suppress matrix metalloproteinase-1 (MMP-1) expression through the down-regulation of Ets1 and c-Jun, c-fos of the AP-1 family."

28672814

Galangin affects RELA

| 1

Galangin inhibits RELA. 1 / 1

| 1

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➶

reach

"Quercetin (25 muM) and galangin (25 muM) markedly inhibited the LPS induced nuclear trans-location of NF-kappaB and p65 (XREF_FIG)."

29207037

Galangin affects NLRP3

| 1

Galangin inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Moreover, western blotting showed that galangin treatment effectively inhibited nuclear factor-kappa B (NF- kappa B), phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) and nucleotide binding domain- (NOD-) like receptor protein 3 (NLRP3) signaling pathway activation."

31240210

Galangin affects MAVS

| 1

Galangin inhibits MAVS. 1 / 1

| 1

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➶

reach

"Our findings indicated that galangin can effectively inhibit murein hydrolase activity as well as the growth of VISA strain Mu50."

29145175

Furosemide affects MAP3K7

| 1

Furosemide inhibits MAP3K7. 1 / 1

| 1

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➶

reach

"Suppression of TAK1 activity had a global effect of suppression of proliferation (XREF_SUPPLEMENTARY), suggesting that basal levels of TAK1 support transit through the cell cycle."

26471266

Fumonisin B1 affects RELA

| 1

Fumonisin B1 inhibits RELA. 1 / 1

| 1

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➶

reach

"Second, our previous study [XREF_BIBR] showed that myriocin or fumonisin B1 significantly reduced nuclear content of p65, a major subunit of NFkappaB [XREF_BIBR], indicating that the elevated CER de novo synthesis results in the increased nuclear translocation of NFkappaB."

29474492

Fumigaclavine C(1+) affects CASP1

| 1

Fumigaclavine C(1+) inhibits CASP1. 1 / 1

| 1

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➶

reach

"Furthermore, in the LPS plus ATP cell model, we found that Fumigaclavine C dose dependent inhibited IL-1beta release and caspase-1 activation."

26320672

Fumaric acid affects NLRP3

| 1

Fumaric acid inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Fumaric acid esters prevent the NLRP3 inflammasome mediated and ATP triggered pyroptosis of differentiated THP-1 cells."

26096886

Fucoxanthin affects JUN

| 1

Fucoxanthin inhibits JUN. 1 / 1

| 1

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➶

reach

"Fucoxanthin and fucoxanthinol induced cell cycle arrest during G1 phase and caspase dependent apoptosis, inhibited the activation of nuclear factor-kappaB, activator protein-1, and phosphatidylinositol 3-kinase/Akt pathways, and down-regulated anti-apoptotic proteins and cell cycle regulators in primary effusion lymphoma cells."

22072997

Fucoxanthin affects CASP1

| 1

Fucoxanthin inhibits CASP1. 1 / 1

| 1

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➶

reach

"Fucoxanthin was also associated with greater glutathione peroxidase (GPx) activity, an amplified TBI associated increase in Beclin 1 and LC3-II and decrease in p62 and SQSTM1, and attenuated cleavage of inflammasome related caspase-1."

29704549

Fucoidan affects RELA

1 |

Fucoidan inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

16201850

Fucoidan affects NFKB1

1 |

Fucoidan inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

16201850

Fructose affects RELA

1 |

Fructose inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

25559852

Forskolin affects TRAF3

| 1

Forskolin inhibits TRAF3. 1 / 1

| 1

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➶

reach

"Forskolin reduces the upshift of c-Raf-1 induced by EGF-treatment."

8003010

Forskolin affects STAT1

| 1

Forskolin inhibits STAT1. 1 / 1

| 1

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➶

reach

"Notably, the DP1 agonist BW and adenylyl cyclase activator Forskolin both inhibited JAK2 and STAT1 activation, which was attenuated by Rp-cAMP but not H89 (XREF_FIG)."

27621415

Forskolin affects RELA

| 1

Forskolin inhibits RELA. 1 / 1

| 1

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➶

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"The results showed that NF-kappaB p65 expression decreased when cells were treated with forskolin, especially at a concentration of 20 muM."

32606960

Forskolin affects MYD88

| 1

Forskolin inhibits MYD88. 1 / 1

| 1

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➶

reach

"We hypothesize that ISOF and forskolin (FSK) pretreatment attenuates inflammation induced by lipopolysaccharide (LPS) related to toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), and nuclear factor kappa B (NF-kappaB) signaling."

30637903

Forskolin affects MAPK8

| 1

Forskolin inhibits MAPK8. 1 / 1

| 1

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➶

reach

"As shown in XREF_FIG, Forskolin inhibited NTHi induced activation of JNK2 but not JNK1."

23575688

Forskolin affects CASP1

| 1

Forskolin inhibits CASP1. 1 / 1

| 1

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➶

reach

"Forskolin, a selective inhibitor of the membrane associated adenylyl cyclase [XREF_BIBR], inhibited IL-1beta, IL-18 and caspase-1 autoproteolysis during A. phagocytophilum infection of macrophages (XREF_SUPPLEMENTARY)."

27482714

Formic acid affects TLR7

| 1

Formic acid inhibits TLR7. 1 / 1

| 1

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➶

reach

"Lower levels of these SCFAs also significantly enhance TLR2 ligand- and TLR7 ligand induced production of IL-8 and TNF-alpha in a time- and dose dependent manner."

29375574

Formic acid affects NFKBIA

| 1

Formic acid inhibits NFKBIA. 1 / 1

| 1

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reach

"In addition, IkappaBalpha involved in NF-kappaB signaling pathways was disrupted by SCFAs."

29532321

Fluvastatin affects RELA

| 1

Fluvastatin inhibits RELA. 1 / 1

| 1

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reach

"Chromatin immunoprecipitation (ChIP) assays demonstrated that fluvastatin and sorafenib synergistically inhibited the binding of NF-kappaB p65 subunit to the SDF-1alpha promoter."

28423574

Fluticasone propionate affects IKBKB

| 1

Fluticasone propionate inhibits IKBKB. 1 / 1

| 1

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➶

medscan

"In vitro fluticasone propionate treatment induced inhibition of both IκB kinaseα and IκB kinaseβ activity in PBMCs from asthmatic patients, patients with chronic obstructive pulmonary disease, and HSs, although IκB kinaseβ activity was more sensitive to fluticasone propionate than that of IκB kinaseα."

21571356

Fluticasone propionate affects CHUK

| 1

Fluticasone propionate inhibits CHUK. 1 / 1

| 1

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➶

medscan

"In vitro fluticasone propionate treatment induced inhibition of both IκB kinaseα and IκB kinaseβ activity in PBMCs from asthmatic patients, patients with chronic obstructive pulmonary disease, and HSs, although IκB kinaseβ activity was more sensitive to fluticasone propionate than that of IκB kinaseα."

21571356

Fluoxetine hydrochloride affects STAT1

| 1

Fluoxetine hydrochloride inhibits STAT1. 1 / 1

| 1

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➶

medscan

"In addition to inhibiting ERK, a selective 5-HTT inhibitor fluoxetine blocked interferon-alpha-induced activations of Src, calmodulin kinase II-regulated Pyk2/GSK-3β cascade, as well as STAT1 activation and translocation."

21898401

Fluoride affects MAPK8

| 1

Fluoride inhibits MAPK8. 1 / 1

| 1

---

➶

eidos

"However , Fraction F did not suppress JNK1 / 2 phosphorylation ."

| PMC

Fluorescein affects RIPK1

| 1

Fluorescein inhibits RIPK1. 1 / 1

| 1

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➶

reach

"Both fluorescein labeled necrostatins inhibit RIP1 kinase activity and demonstrate binding in the FP assay."

22658960

Flufenamic acid affects CASP1

| 1

Flufenamic acid inhibits CASP1. 1 / 1

| 1

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➶

reach

"In addition to inhibiting IL-1beta release from mouse cells, flufenamic acid also inhibited IL-1beta release (XREF_FIG) and production of the active p10 subunit of caspase-1 (XREF_FIG) from nigericin treated human THP-1 cells."

27509875

Fludarabine affects STAT1

1 |

Fludarabine inhibits STAT1. 1 / 1

1 |

---

➶

ctd

No evidence text available

17072862

Flavone affects IFIH1

| 1

Flavone inhibits IFIH1. 1 / 1

| 1

---

➶

sparser

"Two investigators have described inhibition of E. coli helicases (DnaB and RepA) by flavones such as myricetin xref , xref ; however, myricetin is quite promiscuous and cytotoxic."

23231076

Fisetin affects RELA

| 1

Fisetin inhibits RELA. 1 / 1

| 1

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"Furthermore, fisetin treatment also inhibited UVB induced activation and nuclear translocation of NFkappaBp65 as compared to the skin of UVB exposed mice not treated with fisetin (XREF_FIG)."

25169110

Fisetin affects MYD88

| 1

Fisetin inhibits MYD88. 1 / 1

| 1

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reach

"In contrast, fisetin treated mice after OVA induction inhibited activation of MyD88 and NF-kappaB signaling pathways, resulting in downregulation of pro inflammatory cytokine secretion."

29568921

Filipin III affects STAT1

| 1

Filipin III inhibits STAT1. 1 / 1

| 1

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➶

medscan

"In the Jurkat T lymphocyte cell line, which does not express caveolin-1, nuclear translocation of IFNGR-1 and STAT1alpha were similarly inhibited by filipin pretreatment."

12165521

Filipin III affects NFKBIA

| 1

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| 1

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reach

"Strikingly, Filipin reduced the IkappaBalpha and A20 mRNA induction significantly by ~ 40-60%."

27327966

Filgotinib affects JAK1

| 1

Filgotinib inhibits JAK1. 1 / 1

| 1

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reach

"For example, the JAK1 blocker filgotinib was tested in Crohn 's disease, whereas the JAK1/3 inhibitor tofacitinib was tested in clinical trials for both Crohn 's disease and ulcerative colitis."

29051788

Fidaxomicin affects STAT2

| 1

Fidaxomicin inhibits STAT2. 1 / 1

| 1

---

➶

eidos

"Furthermore , the results of western blotting of the expression of STAT2 showed that fidaxomicin did not prevent the degradation of STAT2 in the presence of NS5 either ( Additional file 1 : Fig. S1b ) ."

32731873

Ferulic acid affects NLRP3

| 1

Ferulic acid inhibits NLRP3. 1 / 1

| 1

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➶

reach

"[Sodium Ferulate Attenuates Oxidative Stressvia Suppressing NALP3 Inflammasome and ERK Signal Pathway]."

28598074

Ferulic acid affects MAPK8

1 |

Ferulic acid inhibits MAPK8. 1 / 1

1 |

---

➶

ctd

No evidence text available

15363954

Famotidine affects NFKB1

| 1

Famotidine inhibits NFKB1. 1 / 1

| 1

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reach

"a1AR induced H2R expression, oxidative stress and hypertrophic indices were significantly abolished by famotidine and pharmacological inhibitor of NFkB."

32385805

Ezetimibe affects IFNB1

| 1

Ezetimibe inhibits IFNB1. 1 / 1

| 1

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"Finally, we show that Tg6F and ezetimibe prevent WD induced increases in i) IFN-beta, ii) cholesterol 25-hydroxylase (CH25H), and iii) 25-hydroxycholesterol (25-OHC) in jejunum."

28592401

Exendin-4 affects RELA

| 1

Exendin-4 inhibits RELA. 1 / 1

| 1

---

➶

medscan

"The nuclear fluorescence intensity of NF-κB p65 and the expression level of p38 MAPK protein in the cells were significantly lowered by exendin-4 treatment (P<0.01)."

22931618

Exendin-4 affects JUN

| 1

Exendin-4 inhibits JUN. 1 / 1

| 1

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reach

"Exendin-4 also inhibited the endoplasmic reticulum transmembrane protein IRE1, the apoptosis related signaling molecule JNK, and c-Jun activation."

22518128

Everolimus affects RELA

| 1

Everolimus inhibits RELA. 1 / 1

| 1

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"We found that compared to TNF-alpha stimulated cells, everolimus treatment in the presence of TNF-alpha significantly decreased the p65 staining in the cell nucleus (P < 0.001)."

29889836

Eupatilin affects NFKBIA

| 1

Eupatilin inhibits NFKBIA. 1 / 1

| 1

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"Eupatilin suppressed the TNF-alpha-induced activation of IkappaBalpha and nuclear factor-kappaB (NF-kappaB) signals in BEAS-2B cells."

22862554

Eupatilin affects MYD88

| 1

Eupatilin inhibits MYD88. 1 / 1

| 1

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reach

"We found that ELS significantly increased protein and mRNA levels and secretion of inflammatory factors IL-1beta and TNF-alpha, which Eupatilin attenuated through the Toll like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) pathway."

31476693

Etoricoxib affects MAPK14

1 |

Etoricoxib inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

15990304

Etoposide affects RELA

| 1

Etoposide inhibits RELA. 1 / 1

| 1

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➶

reach

"However, a modest increase in stromal cell nuclear p50, combined with a consistent decrease in nuclear p65 in cells treated with VP-16, results in a ratio less conducive to NF-kappaB-driven VCAM-1 expression.Treatment of stromal cells layers with (E)-Capsaicin reduced VCAM-1 expression at 24 and 48 hr."

11322928

Etoposide affects IRF3

| 1

Etoposide inhibits IRF3. 1 / 1

| 1

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➶

eidos

"VP16 may block IRF3 signaling by binding to IRF3 and blocking the recruitment of the CBP ( CREB-binding protein ) coactivator ( Xing et al. 2013 ) ."

28528439

Ethylenediaminetetraacetic acid affects NLRP3

| 1

Ethylenediaminetetraacetic acid inhibits NLRP3. 1 / 1

| 1

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➶

reach

"We demonstrated that P. acnes -derived proteinase activity is required for P. acnes -mediated inflammasome activation, and that heat or EDTA prevented NLRP3 inflammasome dependent inflammation."

24820890

Ethylenediaminetetraacetic acid affects CASP1

| 1

Ethylenediaminetetraacetic acid inhibits CASP1. 1 / 1

| 1

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reach

"Pre-incubation of P. acnes with EDTA impaired the activation of caspase-1 and inhibited the release of IL-1beta in a concentration dependent manner."

24820890

Ethylene glycol bis(2-aminoethyl)tetraacetate affects MAP3K7

| 1

Ethylene glycol bis(2-aminoethyl)tetraacetate inhibits MAP3K7. 1 / 1

| 1

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➶

reach

"Extracellular (EGTA) or intracellular (BAPTA/AM) Ca (2+) chelator prevented the stretch induced activation of TAK1."

21371434

Ethylene glycol bis(2-aminoethyl)tetraacetate affects JUN

| 1

Ethylene glycol bis(2-aminoethyl)tetraacetate inhibits JUN. 1 / 1

| 1

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➶

reach

"The c-jun induction was partially inhibited when the cells were treated with 2 mM EGTA during MI and the recovery (42% reduction)."

7615838

Ethidium bromide affects IFIH1

| 1

Ethidium bromide inhibits IFIH1. 1 / 1

| 1

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➶

sparser

"DNA-interacting compounds actinomycin, DAPI, daunorubicin, ethidium bromide, netropsin and nogalamycin were able to inhibit the helicase and ssDNA-dependent ATPase activity with apparent IC50 values ranging from 0.5 to 5.0 microM respectively."

18571876

Ethanolamine affects IKBKB

| 1

Ethanolamine inhibits IKBKB. 1 / 1

| 1

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➶

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"Interestingly, another cannabinoid, arachidonoyl ethanolamine, is known to directly inhibits IKKbeta."

30906261

Ethanol affects TBK1

| 1

Ethanol inhibits TBK1. 1 / 1

| 1

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➶

reach

"Notably, 70% ethanol extract of Cephalotaxus koreana specifically down-regulated STING induced, but not TBK1- or IRF3 induced, IFN-beta promoter activity."

28771599

Ethanol affects STAT2

| 1

Ethanol inhibits STAT2. 1 / 1

| 1

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➶

reach

"In conclusion, these findings suggest that chronic alcohol consumption down-regulates STAT2 and PKR, but up-regulates p42/44 mitogen activated protein kinase (p42/44MAP kinase), which may cause down-regulation of IFN-alpha signaling in the liver of ALD patients."

11826419

Ethanol affects ITCH

| 1

Ethanol inhibits ITCH. 1 / 1

| 1

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reach

"Several elders noted that application of rubbing alcohol reduced the itch or sting associated with the bug bite, or made their irritated skin feel better generally."

26543255

Ethanol affects IRF3

| 1

Ethanol inhibits IRF3. 1 / 1

| 1

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➶

reach

"Notably, 70% ethanol extract of Cephalotaxus koreana specifically down-regulated STING induced, but not TBK1- or IRF3 induced, IFN-beta promoter activity."

28771599

Ethanol affects IKBKB

| 1

Ethanol inhibits IKBKB. 1 / 1

| 1

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➶

reach

"XREF_FIG shows that while acute alcohol exposure decreased IKK-beta kinase activity, chronic alcohol increased IKK-beta kinase activity."

19561104

Ethanol affects IFNB1

| 1

Ethanol inhibits IFNB1. 1 / 1

| 1

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➶

reach

"In vivo and in vitro binge alcohol exposure significantly inhibited the TLR4-MyD88 cytokines TNF-alpha and IL-6, as well as the TLR4-TRIF cytokines and chemokines IFN-beta, IP-10, and RANTES, in human monocytes, but not TLR3-TRIF-induced cytokines and chemokines, as detected by quantitative PCR and ELISA."

29445009

Etanercept affects OAS3

| 1

Etanercept inhibits OAS3. 1 / 1

| 1

---

➶

eidos

"For example , OAS1 , OAS2 , OAS3 , and IFI44L appear to be down-regulated by etanercept in responders to treatment for psoriasis [ 38 ] ."

30665420

Etanercept affects OAS2

| 1

Etanercept inhibits OAS2. 1 / 1

| 1

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➶

eidos

"For example , OAS1 , OAS2 , OAS3 , and IFI44L appear to be down-regulated by etanercept in responders to treatment for psoriasis [ 38 ] ."

30665420

Estrogen affects TRIM25

| 1

Estrogen inhibits TRIM25. 1 / 1

| 1

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➶

reach

"Functionally, the estrogen induced EFP impaired the function of KLF5 in the regulation of its target genes such as FGFBP1, while knockdown of EFP enhanced the function of KLF5 in gene regulation (XREF_FIG)."

21542805

Estrogen affects STING1

| 1

Estrogen inhibits STING1. 1 / 1

| 1

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➶

reach

"Loss of estrogen may produce sting effects upon bone structure by modulating the " set point " for bone adaptation."

8363880

Estrogen affects STAT1

| 1

Estrogen inhibits STAT1. 1 / 1

| 1

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➶

reach

"To demonstrate that both ERalpha and STAT1 are necessary for estrogen induced of TLR8 expression, siRNAs targeting STAT1 and ERalpha were transfected into THP-1 cells that were treated with estrogen."

28039018

Estrogen affects JUN

| 1

Estrogen inhibits JUN. 1 / 1

| 1

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➶

reach

"Under normal conditions these estrogen responsive cells are growth inhibited by this agent and medroxyprogesterone acetate decreases c-jun ex- pression and endogenous AP-1 activity."

8180102

Estrogen affects CASP1

| 1

Estrogen inhibits CASP1. 1 / 1

| 1

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➶

reach

"This latter hypothesis is also supported by the fact that estrogen fails to suppress IL-1beta mRNA or the activity of caspase-1, which cleaves precursor IL-1beta to its mature active form, at 24 hours post injury."

16156894

Estradiol affects NFKBIA

| 1

Estradiol inhibits NFKBIA. 1 / 1

| 1

---

➶

eidos

"Furthermore , experimental studies demonstrated that estradiol reduced production of reactive oxygen species ( ROS ) and lipid peroxidation , thus inhibiting IkappaB-alpha degradation and nuclear factor-kappaB ( NF-kB ) activation [ 25 ] ."

32482167

Estradiol affects NFKB1

| 1

Estradiol inhibits NFKB1. 1 / 1

| 1

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➶

reach

"High levels of estradiol, HCG and progesterone during the pregnancy can inhibit secretion of such NFkB induced inflammatory cytokines as IL-1, -2, -3, -5, -8, interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) by Mphis and T cells, while enhance the secretion of the monocyte deactivating cytokine, IL-10 [XREF_BIBR - XREF_BIBR]."

19683334

Estradiol affects JUN

| 1

Estradiol inhibits JUN. 1 / 1

| 1

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➶

reach

"As shown in Fig. 6A, cells expressing DeltavJ-hER mt did not exhibit a significantly increased rate of cell proliferation over control cells in the presence of estradiol.Interestingly, little if any decrease in c-Jun expression was observed in DeltavJ-hER mt CEFs treated with estradiol compared with carrier control."

12932827

Estradiol affects IFNB1

| 1

Estradiol inhibits IFNB1. 1 / 1

| 1

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➶

reach

"In contrast to our findings with epithelial cells, estradiol pretreatment of human dendritic cells inhibits the upregulation of IFNbeta and MxA in response to Newcastle 's Disease Virus (NDV) XREF_BIBR without affecting IFNbeta induced RIG-I, MxA, IP10 or STAT1 expression XREF_BIBR."

22558189

Estradiol affects FOS

| 1

Estradiol inhibits FOS. 1 / 1

| 1

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➶

reach

"We also showed that estradiol suppressed c-fos immunoreactivity in the caudal bed nucleus of the stria terminalis under short days."

23763907

Esculetin affects MAPK14

1 |

Esculetin inhibits MAPK14. 1 / 1

1 |

---

➶

ctd

No evidence text available

16051289

Erythromycin A affects NLRP3

| 1

Erythromycin A inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In vitro, azithromycin and erythromycin inhibited NLRC4 and NLRP3 inflammasomes activation."

28684545

Erythromycin A affects JUN

| 1

Erythromycin A inhibits JUN. 1 / 1

| 1

---

➶

reach

"Erythromycin suppresses nuclear factor-kappaB and activator protein-1 activation in human bronchial epithelial cells."

10623585

Erlotinib affects IRF3

| 1

Erlotinib inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Addition of Erlotinib inhibits transcriptional activation of IRF3 demonstrating that it is driven by EGFR."

25503978

Erlotinib hydrochloride affects TBK1

| 1

Erlotinib hydrochloride inhibits TBK1. 1 / 1

| 1

---

➶

medscan

"Addition of EGF or Erlotinib abolishes TBK1 serine 172 phosphorylation in U251EGFR cells ( )."

25503978

Erlotinib hydrochloride affects RIPK1

| 1

Erlotinib hydrochloride inhibits RIPK1. 1 / 1

| 1

---

➶

medscan

"Exposure of glioblastoma9-NS cells to an EGFR kinase inhibitor, Erlotinib, blocks the EGFRvIII-RIP1 association, as does necrostatin-1, albeit to a lesser extent ( )."

23972990

Erlotinib hydrochloride affects IRF3

| 1

Erlotinib hydrochloride inhibits IRF3. 1 / 1

| 1

---

➶

medscan

"Addition of Erlotinib inhibits transcriptional activation of IRF3 demonstrating that it is driven by EGFR."

25503978

Eriodictyol affects TBK1

1 |

Eriodictyol inhibits TBK1. 1 / 1

1 |

---

➶

ctd

No evidence text available

19426678

Ergosterol affects RELA

| 1

Ergosterol inhibits RELA. 1 / 1

| 1

---

➶

reach

"Furthermore, ergosterol elevated HDAC3 activation and suppressed P300 and CBP and PCAF activation as well as acetyl NF-kappaB and p65 and IKKbeta, demonstrating that HDAC3 deacetylation was involved in the effect of ergosterol on macrophage polarization."

31874368

Ergosterol affects IKBKB

| 1

Ergosterol inhibits IKBKB. 1 / 1

| 1

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➶

reach

"Furthermore, ergosterol elevated HDAC3 activation and suppressed P300 and CBP and PCAF activation as well as acetyl NF-kappaB and p65 and IKKbeta, demonstrating that HDAC3 deacetylation was involved in the effect of ergosterol on macrophage polarization."

31874368

Ergosterol affects DDX58

| 1

Ergosterol inhibits DDX58. 1 / 1

| 1

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➶

reach

"Additionally, ergosterol peroxide inhibited the activation of RIG-I downstream signaling pathways, including p38 MAP kinase and NF-kappaB, which ultimately resulted in the reduced production of an array of pro inflammatory mediators and interferons (IFN-beta and IFN-lambda1)."

31323223

Eplerenone affects NLRP3

| 1

Eplerenone inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In vitro, exposure of podocytes to Aldo enhanced NLRP3, caspase-1, and IL-18 expressions in dose- and time dependent manners, indicating an activation of NLRP3 inflammasome, which was significantly blocked by the mineralocorticoid receptor antagonist eplerenone or the antioxidant N -acetylcysteine."

28052869

Epalrestat affects NLRP3

| 1

Epalrestat inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Epalrestat did not inhibit the NLRP3 inflammasome (XREF_FIG)."

32566101

Enzyme inhibitor affects TRIM25

1 |

Enzyme inhibitor inhibits TRIM25. 1 / 1

1 |

---

➶

ctd

No evidence text available

23301498

Enzyme inhibitor affects RELA

1 |

Enzyme inhibitor inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

23301498

Enzyme inhibitor affects MAVS

1 |

Enzyme inhibitor inhibits MAVS. 1 / 1

1 |

---

➶

ctd

No evidence text available

23301498

Enzyme inhibitor affects JUN

1 |

Enzyme inhibitor inhibits JUN. 1 / 1

1 |

---

➶

ctd

No evidence text available

23301498

Enzyme inhibitor affects IRF9

1 |

Enzyme inhibitor inhibits IRF9. 1 / 1

1 |

---

➶

ctd

No evidence text available

23301498

Enzyme inhibitor affects IKBKG

1 |

Enzyme inhibitor inhibits IKBKG. 1 / 1

1 |

---

➶

ctd

No evidence text available

23301498

Enzyme inhibitor affects IKBKB

1 |

Enzyme inhibitor inhibits IKBKB. 1 / 1

1 |

---

➶

ctd

No evidence text available

23301498

Enalapril affects NLRP3

| 1

Enalapril inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In this study, we also demonstrated that enalapril could significantly attenuate the tubulointerstitial expression of the NLRP3 inflammasome and renal interstitial fibrosis in UUO rats."

27872860

Enalapril affects NFKB1

1 |

Enalapril inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

19225048

Emodin(1-) affects TRAF6

| 1

Emodin(1-) inhibits TRAF6. 1 / 1

| 1

---

➶

reach

"Emodin suppresses angiogenesis and metastasis in anaplastic thyroid cancer by affecting TRAF6 mediated pathways invivo and invitro."

30272291

Emodin(1-) affects RELA

| 1

Emodin(1-) inhibits RELA. 1 / 1

| 1

---

➶

reach

"Emodin inhibited TNF-alpha-induced NF-kappaB p65 and JNK activation but did not affect transforming growth factor beta1 induced Smad2/3 signaling."

17962452

Emodin(1-) affects NLRP3

| 1

Emodin(1-) inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Emodin Inhibited NLRP3 Inflammasome Activation of Alveolar Epithelial Cells."

32546964

Emodin(1-) affects NFKBIA

| 1

Emodin(1-) inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Emodin inhibited the LPS induced degeneration of I kappaB-alpha by corneal fibroblasts in a dose dependent manner (P < 0.05)."

19968079

Emodin(1-) affects IFNAR1

| 1

Emodin(1-) inhibits IFNAR1. 1 / 1

| 1

---

➶

reach

"Emodin enhances the antiproliferative effect of IFN-alpha on cancer cells by promoting the activation of JAK and STAT signaling, which is achieved via inhibition of 26S proteasome stimulated IFNAR1 degradation."

26683360

Emodin affects TRAF6

| 1

Emodin inhibits TRAF6. 1 / 1

| 1

---

➶

reach

"Therefore, we determined the expression levels of these related proteins, and the results indicated that emodin could significantly downregulate the HTRA1, IL-33, MyD88, TRAF-6, and NF-kappaB protein levels, but upregulate the TGF-beta1 protein level, and decrease the TNF-alpha, IL-1beta, and IL-6 mRNA levels."

29163548

Emodin affects MYD88

| 1

Emodin inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Therefore, we determined the expression levels of these related proteins, and the results indicated that emodin could significantly downregulate the HTRA1, IL-33, MyD88, TRAF-6, and NF-kappaB protein levels, but upregulate the TGF-beta1 protein level, and decrease the TNF-alpha, IL-1beta, and IL-6 mRNA levels."

29163548

Emetine affects MAPK8

| 1

Emetine inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"In contrast, emetine, an inhibitor of the ribotoxic stress response, was unable to inhibit the activation of JNK1 by oxidative stressors."

10464319

Emetine affects MAPK14

1 |

Emetine inhibits MAPK14. 1 / 1

1 |

---

➶

ctd

No evidence text available

26332055

Emetine affects IFNAR1

| 1

Emetine inhibits IFNAR1. 1 / 1

| 1

---

➶

reach

"The serum viral load of ZIKV infected Ifnar1 -/- mice was significantly lower when animals were treated with emetine compared with vehicle control (VC)."

29872540

Emetine affects CHUK

| 1

Emetine inhibits CHUK. 1 / 1

| 1

---

➶

reach

"Surprisingly, Emetine downregulated IKK-beta, but not IKK-alpha, subunit protein."

27682876

Emedastine affects ITCH

| 1

Emedastine inhibits ITCH. 1 / 1

| 1

---

➶

reach

"The present study showed that emedastine difumarate inhibits itch associated responses at relatively low peroral doses (0.03-0.3 mg/kg), which are comparable to clinical doses (Furue and Yamashita, 1997; Ishibashi et al., 1994)."

11011046

Embelin affects RIPK1

| 1

Embelin inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"Caspase inhibition restored RIP levels; conversely, caspase induction with embelin triggered RIP cleavage."

16339139

Embelin affects RELA

| 1

Embelin inhibits RELA. 1 / 1

| 1

---

➶

reach

"Moreover, embelin suppressed the activation of p65 subunit of nuclear factor-kappa B (NF-kappaB) and signal transducers and activators of transcription 3 (STAT3)."

25682469

Ellagic acid affects NFKB1

| 1

Ellagic acid inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Edderkaoui et al 6 reported that ellagic acid inhibits the NFkB pathway and that embellin inhibits STAT3 activity via reduced expression of apoptotic inhibitors, namely, survivin and XIAP."

29279018

Electrophilic reagent affects IKBKB

| 1

Electrophilic reagent inhibits IKBKB. 1 / 1

| 1

---

➶

sparser

"Thus, inactivation of IKKβ by electrophiles results in inhibition of NF-κB independently of the upstream mechanisms that induced activation of IKKβ."

31849641

Electron affects RELA

| 1

Electron inhibits RELA. 1 / 1

| 1

---

➶

eidos

"Furthermore , pharmacological inhibition of TAK1 and IKKalpha / beta blocked NF-kappaB p65 activation and subsequent production of pro-inflammatory cytokines by MxA silencing ."

32445727

Effector affects RELA

| 1

Effector inhibits RELA. 1 / 1

| 1

---

➶

reach

"Secretion of this effector prevents the nuclear translocation of RELA, but the direct host target of AopP is unknown."

21383764

Effector affects PYCARD

| 1

Effector inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Irradiation of CNS effector cells reduced CpG and R848 ASC frequencies back to feeder only culture frequencies (Fig. 4A)."

28495370

Effector affects IFNB1

| 1

Effector inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Using a distinct mechanism to C. rodentium, an EPEC T3SS effector, NleD, reduces IFN-β induction by inhibition of RNase L, ultimately resulting in evasion of antibacterial activities and disruption of barrier function (91)."

28352268

Ecgonine benzoate affects MYD88

| 1

Ecgonine benzoate inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Loss of response in MyD88 deficient macrophages showed that both MIP and BCG activate the macrophages in a MyD88 dependent manner."

24766519

Ebselen affects NLRP3

| 1

Ebselen inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"It was found that ebselen, a putative ONOO - scavenger, failed to decrease formation and activation of NLRP3 inflammasomes in podocytes treated with Hcys, suggesting ONOO - may not play a critical redox role in this particular pathological process in podocytes."

24140862

Ebselen affects NFKB1

| 1

Ebselen inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Moreover, ebselen did not prevent IL-lbeta-induced NF-KB activation."

8986132

Ebselen affects JUN

| 1

Ebselen inhibits JUN. 1 / 1

| 1

---

➶

reach

"At micromolar concentrations, ebselen, selenomethionine, and selenocysteine effectively prevented nuclear accumulation of activator protein-1 (AP-1) and nuclear factor kappaB (NF-kappaB) evoked by exogenous ONOO (-), in both polymorphonuclear and mononuclear leukocytes, and inhibited IL-8 gene and protein expression."

14572605

Dynasore affects IFNB1

| 1

Dynasore inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"IFN-β synthesis was strongly diminished by both dynasore and chloroquine treatments."

22432012

Drug affects STAT1

| 1

Drug inhibits STAT1. 1 / 1

| 1

---

➶

reach

"A drug that specifically inhibits the IFN-γ receptor or STAT1 shows an anti-ZIKV effect and might also have anti-inflammatory activity."

28468880

Drug affects MYD88

| 1

Drug inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Since MyD88 is at a key point of innate immune signaling, its suppression by siRNAs or a small molecule drug inhibiting MyD88 function may be highly efficient if inappropriate overshooting inflammatory reactions in the heart accompany the an-tiviral response."

16329668

Drug affects JAK1

| 1

Drug inhibits JAK1. 1 / 1

| 1

---

➶

reach

"Baricitinib, is not only expected to interrupt the passage and intracellular assembly of SARS-CoV-2 into the target cells mediated by ACE2 receptor, but also promises to be a specific drug that blocks cytokine storms by suppressing JAK1/JAK2 [6]."

| PMC

Doxycycline affects RELA

| 1

Doxycycline inhibits RELA. 1 / 1

| 1

---

➶

medscan

"Withdrawal of Doxycycline- reduces basal transcriptional activity of RelA, restrains IRF1 expression, and the interferon response downstream of IRF1 is terminated and the cells return to cycling."

26460486

Doxycycline affects NFKBIA

| 1

Doxycycline inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"However, minocycline and doxycycline did not significantly suppress phospho-IkappaBalpha."

29124230

Doxycycline affects IKBKB

| 1

Doxycycline inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"For IKK2-CA repression doxycycline (0,5 g/l) was administered in the drinking water of all mice from conception to 4weeks of age and as indicated in Fig."

28193238

Doxycycline affects IFNB1

| 1

Doxycycline inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Doxycycline Induces Mitophagy and Suppresses Production of Interferon-beta in IPEC-J2 Cells."

28203548

Doxycycline affects FOS

| 1

Doxycycline inhibits FOS. 1 / 1

| 1

---

➶

reach

"As described in Box 1, c-fos induction of the tTA gene is repressed by doxycycline in the drinking water prior to learning."

24088811

Doxorubicin affects RIPK1

| 1

Doxorubicin inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"We demonstrate that there is a synergistic interaction in which ganetespib potentiates doxorubicin induced cell death in part by eliciting persistent G2/M arrest and blocking doxorubicin induced RIP1 activation."

24166505

Doxorubicin affects NLRP3

| 1

Doxorubicin inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Dihydromyricetin alleviates doxorubicin induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1."

32112883

Doxorubicin affects MAPK14

1 |

Doxorubicin inhibits MAPK14. 1 / 1

1 |

---

➶

ctd

No evidence text available

15936597

Dorsomorphin affects PYCARD

| 1

Dorsomorphin inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Supporting this, compound C also inhibited the release of IL-1beta and the formation of ASC specks in these cells."

28018360

Dopamine affects STING1

| 1

Dopamine inhibits STING1. 1 / 1

| 1

---

➶

reach

"Interestingly, dopamine and 5-HT (but not octopamine or 20-hydroxyecdisone) have been shown to decrease the conditioned sting extenstion response, while 5-HT 2 receptor antagonists increase responsiveness."

26441567

Dopamine affects NFKB1

| 1

Dopamine inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Moreover, dopamine markedly down-regulated inflammation related protein expression levels and p50 and p65 NF-kappaB nuclear localization in tumor cells, thereby inhibiting increases in tumor weight and size in xenograft mice."

29179451

Dopamine affects CASP1

| 1

Dopamine inhibits CASP1. 1 / 1

| 1

---

➶

reach

"The results showed that DA could inhibit caspase-1 cleavage and IL-1beta secretion induced by all examined agonists, including MSU, Alum, and ATP, similar to nigericin, suggesting that DA is a potent and broad inhibitor for NLRP3 inflammasome activation."

25594175

Divinyl sulfone affects NLRP3

| 1

Divinyl sulfone inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Known for their anti-inflammatory properties, natural products such as Oridonin (found in Rabdosia rubescens plant) and Parthenolide (sesquiterpene lactone found in feverfew plant) as well as synthetic compound Bay 11-7082 and related vinyl sulfone compounds have been shown to exert their effects via inhibition of the NLRP3 inflammasome."

32574259

Divanadium pentaoxide affects STAT1

| 1

Divanadium pentaoxide inhibits STAT1. 1 / 1

| 1

---

➶

reach

"V2O5 induced STAT-1 activation was blocked by catalase and N-acetyl-L-cysteine (NAC), suggesting vanadium induced generation of H2O2."

14556849

Diterpenoid affects JUN

| 1

Diterpenoid inhibits JUN. 1 / 1

| 1

---

➶

sparser

"The isolated labdane diterpenoid significantly inhibited c-Jun in the AP-1 pathway at 50 μM, indicating that inhibition of AP-1 is the mechanism by which the isolated compound exhibited its anti-inflammatory behaviour."

25705127

Disulfur affects TRAF6

| 1

Disulfur inhibits TRAF6. 1 / 1

| 1

---

➶

reach

"S2 A. Depletion of TRAF6 in skeletal muscle tissues was assessed by semiquantitative reverse transcription PCR using TRAF6 exon 7, internal ribosome entry site (IRES), and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) primers."

21187332

Disulfiram affects RELA

1 |

Disulfiram inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

10661865

Disulfiram affects CASP1

| 1

Disulfiram inhibits CASP1. 1 / 1

| 1

---

➶

sparser

"A study reported in 1997 showed potent caspase-1 inhibition by disulfiram [ xref ], which would block pro–IL-18 maturation."

25963312

Disodium selenite affects RELA

1 |

Disodium selenite inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

14737004

Disodium cromoglycate affects ITCH

| 1

Disodium cromoglycate inhibits ITCH. 1 / 1

| 1

---

➶

reach

"The aim of this study was to investigate whether topical sodium cromoglicate can reduce the severity of itch induced by intradermal histamine."

21385340

Dipyrithione affects STAT1

| 1

Dipyrithione inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Dipyrithione inhibits IFN-γ-induced JAK/STAT1 signaling pathway activation and IP-10/CXCL10 expression in RAW264.7 cells.Mononuclear phagocytes play an essential role in the regulation of host defense and homeostasis, and in the development of acute and chronic inflammatory diseases."

20372968

Diphenhydramine affects ITCH

| 1

Diphenhydramine inhibits ITCH. 1 / 1

| 1

---

➶

reach

"In contrast, 2% diphenhydramine reduced peak itch intensity by 1.16 +/-0.42 VAS units, equivalent to a 17.6% reduction (P = 0.057, not significant [ns]); did not reduce the duration of itch, which was in fact prolonged on average by 24.9 seconds; and reduced total itch perceived (AUC) by 8.6% (ns) (XREF_FIG)."

25941445

Diphenhydramine affects FOS

| 1

Diphenhydramine inhibits FOS. 1 / 1

| 1

---

➶

reach

"The H1 histamine antagonist diphenhydramine, but not the H2 histamine antagonist cimetidine, reduced the amount of c-fos labeling."

8193936

Dioxygen affects NFKBIA

| 1

Dioxygen inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Conversely, scavenging reactive oxygen species from mitochondria promoted IkappaBalpha degradation with loss of regulatory and promotion of inflammatory T cell responses in vivo."

27184852

Dioxygen affects MAVS

| 1

Dioxygen inhibits MAVS. 1 / 1

| 1

---

➶

reach

"Besides, TRX2 inhibits the formation of VISA aggregates by repressing reactive oxygen species (ROS) production, thereby disrupting the assembly of VISA complex."

31915282

Dioxygen affects JUN

| 1

Dioxygen inhibits JUN. 1 / 1

| 1

---

➶

reach

"Removal of intracellular reactive oxygen species by N-acetyl-cysteine reduced the activation of AMP activated protein kinase, extracellular signal regulated kinase and Jun N-terminal kinase, and interleukin-8 induction."

23222262

Dioxygen affects ITCH

| 1

Dioxygen inhibits ITCH. 1 / 1

| 1

---

➶

reach

"The reactive oxygen species scavengers N-acetylcysteine (NAC; 204 mg/kg i.p.; 86%) or superoxide dismutase (SOD; 10 mg/kg i.p.; 83%) also inhibited itch."

23271050

Dioxygen affects IRF3

| 1

Dioxygen inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Calcium disruption (as through the SERCA pump inhibitor thapsigargin) and oxygen glucose deprivation activate IRF3 through a STING dependent mechanism, whereas agents that disrupt N linked glycosylation (e.g., tunicamycin) appear to utilize a STING independent, but Site-1 and Site-2 protease (ATF6?)"

29556237

Dioxygen affects IFNB1

| 1

Dioxygen inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Cellular reactive oxygen species inhibit MPYS induction of IFNbeta."

21170271

Dioxygen affects FOS

| 1

Dioxygen inhibits FOS. 1 / 1

| 1

---

➶

reach

"Thus, a decrease of the intracellular reactive oxygen intermediate level by hypoxia induces c-fos via the MAPK pathway."

9287359

Diosgenin affects NFKBIA

| 1

Diosgenin inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Elucidation of colon-protective efficacy of diosgenin in experimental TNBS induced colitis : inhibition of NF-kappaB and IkB-alpha and Bax and Caspase -1 signaling pathways."

32525764

Diosgenin affects IKBKB

| 1

Diosgenin inhibits IKBKB. 1 / 1

| 1

---

➶

medscan

"Diosgenin significantly reduced palmitate-enhanced IKKβ and NF-κB phosphorylation with inhibition of TNF-α and IL-6 production in endothelial cells at the concentrations of 0.1, 1 and 10 μmol/L, well demonstrating its anti-inflammatory activity in an IKKβ/NF-κB-dependent fashion."

22766331

Dioscin affects RELA

| 1

Dioscin inhibits RELA. 1 / 1

| 1

---

➶

reach

"In addition, TLR4, myeloid differentiation primary response gene 88 (MyD88), p-IKKbeta, p-p65, and NF-kappaB p65 in nuclei levels were significantly reduced by dioscin."

32761488

Dioscin affects NLRP3

| 1

Dioscin inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Western blotting results suggested that dioscin inhibited the activation of NLRP3 through down-regulating the protein expressions of NLRP3, apoptosis associated speck like protein containing a caspase recruitment domain (ASC), cleaved-caspase-1, as well as IL-1beta."

32761488

Dioscin affects IKBKB

| 1

Dioscin inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"In addition, TLR4, myeloid differentiation primary response gene 88 (MyD88), p-IKKbeta, p-p65, and NF-kappaB p65 in nuclei levels were significantly reduced by dioscin."

32761488

Dinitrogen affects RELA

| 1

Dinitrogen inhibits RELA. 1 / 1

| 1

---

➶

reach

"In E. coli, nitrogen regulation two-component system NtrB and NtrC are encoded by glnL and glnG, respectively, and nitrogen starvation results in the phosphorylation of the response regulator NtrC and the activation of RelA."

30154778

Dinitrogen oxide affects FOS

| 1

Dinitrogen oxide inhibits FOS. 1 / 1

| 1

---

➶

reach

"Hagihira et al. reported that nitrous oxide reduced c-Fos in the neck of dorsal horn (lamina V-X), but not in the superficial layers (laminae I-II)."

23708866

Diminazene affects RELA

1 |

Diminazene inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

25883526

Dimethyl sulfoxide affects STAT1

| 1

Dimethyl sulfoxide inhibits STAT1. 1 / 1

| 1

---

➶

reach

"BMDMs treated with increasing amounts of a JAK1 inhibitor show decreased levels of STAT1 phosphorylation compared to cells treated with DMSO (XREF_FIG)."

30833347

Dimethyl sulfoxide affects PYCARD

| 1

Dimethyl sulfoxide inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Additionally, DMSO concentrations of 10% or higher reduce the number of porcine ASC fibroblastic colony forming units and increase cell apoptotic gene expression after cryopreservation [XREF_BIBR]."

26537238

Dimethyl sulfoxide affects MAPK8

| 1

Dimethyl sulfoxide inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"Altogether our results suggest that (i) JNK1 participates in the signaling pathway which controls the expression of cyclin D2 and (ii) that the inhibition of JNK1 by DMSO and forskolin could explain, at least in part, the antiproliferative action of these drugs in 7TD1 cells."

11082292

Dimethyl sulfoxide affects MAP3K7

| 1

Dimethyl sulfoxide inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"Thus, Traf6-TG and NTG mice were treated with 5z-7-ox (an inhibitor of Tak1) or DMSO (the same volume as the 5z-7-ox solution) as a control."

27249171

Dimethyl sulfoxide affects IFNB1

| 1

Dimethyl sulfoxide inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"The infected cells were treated with DMSO (lanes 3, 5) or 10 μ M of LMB (lane 4) for another 3 h.GLTSCR2 attenuates IFN-β."

27824081

Dimethyl sulfoxide affects FOS

| 1

Dimethyl sulfoxide inhibits FOS. 1 / 1

| 1

---

➶

reach

"The expression of interleukin 6, and of oncogenes c-myc and c-fos were inhibited when the cells were treated with 2% DMSO from the beginning of serum stimulated growth but not after 3 h of mitogenic stimuli."

1909967

Dimethyl sulfoxide affects CHUK

| 1

Dimethyl sulfoxide inhibits CHUK. 1 / 1

| 1

---

➶

reach

"While treatment of HFF cells with IKKalpha siRNA (XREF_FIG, lane 2) decreased IKKalpha levels compared to cells treated with DMSO (XREF_FIG, lane 1), we observed no obvious difference between H3K9ac, H3K18ac or H3K27ac."

26930276

Dimethyl sulfoxide affects CASP1

| 1

Dimethyl sulfoxide inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Control cells treated with b-AP15 inhibitor of UCH-L5 had lower caspase-1 activity than control cells treated with vehicle control (DMSO; XREF_FIG)."

26267804

Dimethyl sulfide affects CASP1

| 1

Dimethyl sulfide inhibits CASP1. 1 / 1

| 1

---

➶

reach

"We further tested whether MSM inhibited the Casp1 activity."

25461402

Dimethyl fumarate affects RELA

1 |

Dimethyl fumarate inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

26683377

Diltiazem affects RELA

1 |

Diltiazem inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

15652234

Diltiazem affects NFKB1

1 |

Diltiazem inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

15652234

Diltiazem affects MAPK8

1 |

Diltiazem inhibits MAPK8. 1 / 1

1 |

---

➶

ctd

No evidence text available

11937779

Diiodine affects PYCARD

| 1

Diiodine inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"15 Povidone iodine and polyhexanide also decrease ASC viability and significantly reduce the expression of stem cell markers (CD29, CD34, CD73, CD90, CD105)."

32095390

Diiodine affects IRF3

| 1

Diiodine inhibits IRF3. 1 / 1

| 1

---

➶

reach

"This result suggests that Galpha i2 restricts IRF3 mediated signaling downstream of LPS."

30683698

Dihydrogen affects TANK

| 1

Dihydrogen inhibits TANK. 1 / 1

| 1

---

➶

reach

"No proton blocking L-C tank circuit was found to be necessary for the 13 C coil."

32244610

Dihydrogen affects CASP1

| 1

Dihydrogen inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Hydrogen rich water effectively attenuated the increased caspase-1 activity, which resulted in correlation with the excessive activation of inflammasome after CUMS treatment (XREF_FIG)."

27026206

Dihydroartemisinin affects TICAM1

| 1

Dihydroartemisinin inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"Consequently, the recruitment of adaptors, MyD88 and TRIF, to TLR4 is attenuated in cells treated with DHA, leading the diminished expression of inflammatory genes such as TNF-alpha and COX-2."

27085899

Dihydroartemisinin affects RIPK1

| 1

Dihydroartemisinin inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"It would be of interest to determine in future studies if DHA preferentially attenuates RIPK1- or RIPK3 dependent necroptosis."

25095742

Dihydroartemisinin affects MAP3K7

| 1

Dihydroartemisinin inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"Consequently, we determined whether DHA stimulation of GPR120 inhibited TAK1 and MKK4."

20813258

Dihydroartemisinin affects IKBKB

| 1

Dihydroartemisinin inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"AA quenches ROS intermediates involved in the activation of NF-kappaB and is oxidized to DHA, which directly inhibits IKKbeta and IKKalpha enzymatic activity."

15254232

Digoxin affects IFNB1

| 1

Digoxin inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"We found that ouabain and digoxin, two cardiac glycosides clinically approved to treat congestive heart failure and cardiac arrhythmias XREF_BIBR, are also able to potently inhibit IFNbeta induction, and this inhibition is also dose dependent (XREF_FIG)."

21076398

Digitoxin affects STAT1

| 1

Digitoxin inhibits STAT1. 1 / 1

| 1

---

➶

eidos

"Other cardenolides digoxin , digitoxin , oleandrin , digitoxigenin , and digoxin-BSA also significantly downregulated JAK1 protein levels and STAT1 ( a , b ) and STAT3 phosphorylation ( a ) ."

| PMC

Digitoxin affects NFKB1

| 1

Digitoxin inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Expression of these cytokines and chemokines depend on NFkB, which is blocked by digitoxin."

| DOI

Digitoxigenin affects STAT1

| 1

Digitoxigenin inhibits STAT1. 1 / 1

| 1

---

➶

eidos

"Other cardenolides digoxin , digitoxin , oleandrin , digitoxigenin , and digoxin-BSA also significantly downregulated JAK1 protein levels and STAT1 ( a , b ) and STAT3 phosphorylation ( a ) ."

| PMC

Diclofenac affects ITCH

| 1

Diclofenac inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Intravenous tenoxicam and rectal diclofenac have been reported to attenuate neuraxial opioid induced itch."

25861787

Dibenziodolium affects RELA

| 1

Dibenziodolium inhibits RELA. 1 / 1

| 1

---

➶

medscan

"These results suggest that diphenylene iodonium blocks the production of mitochondrial reactive oxygen species in gastric cancer cell lines, thus inhibiting NF-κB p65 translocation."

24030146

Dibenziodolium affects NLRP3

| 1

Dibenziodolium inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Pre-treatment for 30 min with the ROS inhibitor, diphenyleneiodonium (DPI, 10 microM, Sigma-Aldrich), substantially reduced NLRP3 and caspase-1 activation (XREF_FIG) and subsequently IL-1beta secretion in mDCs upon IN/11 infection (XREF_FIG)."

26068782

Dibenziodolium affects NFKB1

1 |

Dibenziodolium inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

18922898

Dibenziodolium affects JAK1

| 1

Dibenziodolium inhibits JAK1. 1 / 1

| 1

---

➶

reach

"An NADPH oxidase inhibitor diphenyleneiodonium (DPI) suppressed H. pylori induced activation of Jak1 and Stat3 in AGS cells, suggesting that ROS may activate Jak1 and Stat3, determined by phosphorylation of Jak1 and Stat3."

25837197

Dibenziodolium affects CASP1

| 1

Dibenziodolium inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Pre-treatment for 30 min with the ROS inhibitor, diphenyleneiodonium (DPI, 10 microM, Sigma-Aldrich), substantially reduced NLRP3 and caspase-1 activation (XREF_FIG) and subsequently IL-1beta secretion in mDCs upon IN/11 infection (XREF_FIG)."

26068782

Dibenziodolium chloride affects NLRP3

| 1

Dibenziodolium chloride inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Finally, RSV and Japanese encephalitis virus (JEV) have both been found to induce NLRP3 activation through K + efflux from the cell and ROS production as treatment with K + buffered medium or the ROS inhibitors APDC or diphenyleneiodonium chloride (DPI) inhibited NLRP3 inflammasome activation."

23947344

Dibenziodolium chloride affects CASP1

| 1

Dibenziodolium chloride inhibits CASP1. 1 / 1

| 1

---

➶

reach

"To verify whether NADPH oxidase induced ROS by ATP may modulate mROS production in GECs, we measured ATP induced mROS generation after inhibiting NADPH oxidase with diphenyleneiodonium chloride (DPI), which was previously shown to block caspase-1 activation XREF_BIBR."

23936165

Diarsenic trioxide affects STAT1

1 |

Diarsenic trioxide inhibits STAT1. 1 / 1

1 |

---

➶

ctd

No evidence text available

17121903

Diarsenic trioxide affects NLRP3

| 1

Diarsenic trioxide inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5 and NLRC4 inflammasomes."

24337744

Diarsenic trioxide affects NFKB1

1 |

Diarsenic trioxide inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

18922898

Diarsenic trioxide affects MAPK8

1 |

Diarsenic trioxide inhibits MAPK8. 1 / 1

1 |

---

➶

ctd

No evidence text available

20534739

Diarsenic trioxide affects FOS

1 |

Diarsenic trioxide inhibits FOS. 1 / 1

1 |

---

➶

ctd

No evidence text available

29049341

Diarsenic trioxide affects CASP1

| 1

Diarsenic trioxide inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Arsenic trioxide does not directly inhibit caspase-1 enzymatic activity."

24337744

Diallyl trisulfide affects TRAF6

| 1

Diallyl trisulfide inhibits TRAF6. 1 / 1

| 1

---

➶

medscan

"Diallyl trisulfide induces apoptosis by suppressing NF-κB signaling through destabilization of TRAF6 in primary effusion lymphoma."

26647777

DiOC18(3) dye affects RELA

| 1

DiOC18(3) dye inhibits RELA. 1 / 1

| 1

---

➶

reach

"Interestingly, DIO suppressed gastric MPO, TNF-alpha and NF-kappaB p65 with enhancement of the anti-inflammatory IL-10 levels."

25821971

Dexmedetomidine affects STAT1

| 1

Dexmedetomidine inhibits STAT1. 1 / 1

| 1

---

➶

reach

"In addition, dexmedetomidine significantly reduced the expression of phosphorylated forms of JAK2, STAT1 and STAT3, and provided the same renoprotective effect as AG490 in our study."

23759023

Dexamethasone affects TICAM1

| 1

Dexamethasone inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"In contrast, dexamethasone only attenuated the increases of TLR3 and TRIF in non smokers, but not in smokers or smokers with COPD."

25652132

Dexamethasone affects TBK1

| 1

Dexamethasone inhibits TBK1. 1 / 1

| 1

---

➶

reach

"Additionally, glucocorticoid dexamethasone could attenuate TBK1 activity through suppress its kinase activity, in addition to inhibiting its phosphorylation [47] ."

23395611

Dexamethasone affects STAT1

| 1

Dexamethasone inhibits STAT1. 1 / 1

| 1

---

➶

reach

"3.5 Dexamethasone Fails to Inhibit STAT1 Activation upon Challenge with IFN-gamma or PbNK65 Extract and IFN-gamma."

29033931

Dexamethasone affects ITCH

| 1

Dexamethasone inhibits ITCH. 1 / 1

| 1

---

➶

reach

"In addition, dexamethasone, a steroid drug with potent anti-inflammatory and immunosuppressant effects, can not relieve AEW itch (data not shown), despite its wide use in treating chronic skin diseases including psoriasis and atopic dermatitis."

27118771

Dexamethasone affects IRF7

| 1

Dexamethasone inhibits IRF7. 1 / 1

| 1

---

➶

medscan

"Furthermore, SP600125 and dexamethasone inhibited LPS-induced IFN regulatory factor-7 activity."

16237059

Dexamethasone affects CASP1

| 1

Dexamethasone inhibits CASP1. 1 / 1

| 1

---

➶

reach

"However, dexamethasone does not prevent the accumulation and partial processing of caspase-1 protein or the release of cytochrome c from mitochondria."

11404083

Desmosterol affects RELA

| 1

Desmosterol inhibits RELA. 1 / 1

| 1

---

➶

reach

"Although these results suggested that desmosterol inhibited NFkappaB dependent gene expression at the level of transcription, ChIP experiments indicated that desmosterol treatment did not prevent binding of the p65 subunit of NFkappaB to target response elements (XREF_SUPPLEMENTARY)."

23021221

Desloratadine affects ITCH

| 1

Desloratadine inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Desloratadine did not reduce itch significantly."

14520518

Desferrioxamine B affects RIPK1

| 1

Desferrioxamine B inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"Deferoxamine treatment suppressed TNF-alpha and RIPK1 upregulation and attenuated white matter edema after ICH."

25863131

Desferrioxamine B affects RELA

| 1

Desferrioxamine B inhibits RELA. 1 / 1

| 1

---

➶

reach

"51 In our study, we found that DFO could downregulate ERK, JNK, p38 and p65 activation in osteoclast differentiation, evidenced by little ERK, JNK, p38 and p65 phosphorylation after DFO treatment."

27787522

Deoxynivalenol affects NFKB1

1 |

Deoxynivalenol inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

8887449

Deoxynivalenol affects MAPK8

1 |

Deoxynivalenol inhibits MAPK8. 1 / 1

1 |

---

➶

ctd

No evidence text available

20708668

Deoxycholate affects RIPK1

| 1

Deoxycholate inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"DC dependent inhibition of RIP on ToxR was also observed under alkaline and starvation conditions, indicating that DC rescues ToxR from becoming a substrate for RIP independently of the proteases."

30218472

Delta-tocotrienol affects RELA

| 1

Delta-tocotrienol inhibits RELA. 1 / 1

| 1

---

➶

reach

"Our Western blot results clearly show that NF-kappaB and p65 and NF-kappaB and p50 proteins and the NF-kappaB transcriptional targets Bcl-X L, survivin, and XIAP were moderately down-regulated by delta-tocotrienol alone."

21971120

Delta-tocotrienol affects JUN

| 1

Delta-tocotrienol inhibits JUN. 1 / 1

| 1

---

➶

reach

"The proliferation inhibition effect of delta-tocotrienol on colon cancer cell may correlate with the ability of delta-tocotrienol to downregulate the expression levels of wnt-1, beta-catenin, c-jun, cylin D1 in the Wnt signal pathway."

23424864

Delphinidin chloride affects FOS

| 1

Delphinidin chloride inhibits FOS. 1 / 1

| 1

---

➶

reach

"We further provide evidence that delphinidin suppressed the activity of NF-kappaB, c-fos, and Nfatc1, master transcriptional factors for osteoclastogenesis."

24824988

Dehydroascorbic acid affects NFKBIA

| 1

Dehydroascorbic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Vitamin C is a kinase inhibitor : dehydroascorbic acid inhibits IkappaBalpha kinase beta."

15254232

Dauricine affects RELA

| 1

Dauricine inhibits RELA. 1 / 1

| 1

---

➶

reach

"The results showed that H5N1 and D39 co-infection dramatically induced the nuclear translocation of NF-kappaB and p65, whereas dauricine dramatically repressed the nuclear entry of NF-kappaB and p65 in a dose dependent manner."

29769163

Daunorubicin(1+) affects NFKBIA

| 1

Daunorubicin(1+) inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Consistent with the activation of DNA binding, UV-C or daunorubicin induced IkappaBalpha degradation is much delayed relative to that seen with TNF, which occurs within minutes in these cells (data not shown)."

15053878

Dasatinib (anhydrous) affects NLRP3

| 1

Dasatinib (anhydrous) inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In LPS treated mice, dasatinib attenuated NLRP3 inflammasome activation, c-Abl and PKCdelta activation; and sickness behavior."

28466394

Daidzein affects NLRP3

| 1

Daidzein inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"X-11-5-27, a daidzein derivative, inhibits NLRP3 inflammasome activity via promoting autophagy."

28942022

Dactolisib affects STAT1

| 1

Dactolisib inhibits STAT1. 1 / 1

| 1

---

➶

reach

"STAT1 was downregulated by both everolimus (*, P < 0.05) and NVP-BEZ235 (**, P < 0.01), although NVP-BEZ235 effect was more pronounced."

25216518

Cytosine affects MAVS

| 1

Cytosine inhibits MAVS. 1 / 1

| 1

---

➶

reach

"KAP1 is relevant to the mode of action of anti-cancer 5-AZA-based drugs since KAP1 and cytosine methylation repress some of the same ERVs and suppress MAVS dependent RNA sensing (see Fig XREF_FIG for a model)."

30061100

Cytochalasin D affects STAT1

1 |

Cytochalasin D inhibits STAT1. 1 / 1

1 |

---

➶

ctd

No evidence text available

28086195

Cytochalasin D affects IFNB1

| 1

Cytochalasin D inhibits IFNB1. 1 / 1

| 1

---

➶

medscan

"Inhibitors of endocytosis (cytochalasin D and Dynasore) , ( ) as well as endosomal acidification inhibitor (bafilomycin A) ( ), prevented activation of IFN-β (left) and NF-κB (right) pathway."

24651829

Cytochalasin B affects MAPK8

| 1

Cytochalasin B inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"Activation of JNK1 by Tat was also inhibited by cytochalasin B, suggesting that Tat signaling was dependent upon intact cytoskeletal function."

11448159

Cytochalasin B affects MAPK14

| 1

Cytochalasin B inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Cytochalasin B pretreatment attenuated p38mitogen-activated protein kinase and JNK effects (p < 0.05) without altering ERK1/2 phosphorylation."

15759055

Cytisine affects FOS

| 1

Cytisine inhibits FOS. 1 / 1

| 1

---

➶

reach

"In addition, immunohistochemical analyses indicated that cytisine could reduce c-fos immunoreactivity in the basolateral amygdala by approximately 50%."

17320916

Cytarabine affects RELA

1 |

Cytarabine inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

12853972

Cysteamine affects JUN

| 1

Cysteamine inhibits JUN. 1 / 1

| 1

---

➶

reach

"In support of this idea, cysteamine attenuates the DNA binding of two factors - activator protein 1 and NF-kappaB [XREF_BIBR] - that bind to the TG 1 and TG 2 promoters [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

20161049

Cypermethrin affects MAPK8

1 |

Cypermethrin inhibits MAPK8. 1 / 1

1 |

---

➶

ctd

No evidence text available

29471534

Cyclosporin A affects TRIM25

| 1

Cyclosporin A inhibits TRIM25. 1 / 1

| 1

---

➶

reach

"Higher CsA concentration (10 microM) strongly suppressed EFP."

12453473

Cyclosporin A affects STAT2

| 1

Cyclosporin A inhibits STAT2. 1 / 1

| 1

---

➶

reach

"CsA prevents the pulldown of IRF9, STAT1 and STAT2 by CypA (XREF_FIG)."

22902549

Cyclosporin A affects NFKBIA

| 1

Cyclosporin A inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"CsA suppressed the promoter activity by attenuating IkappaB-alpha degradation."

15286717

Cyclosporin A affects MAPK14

| 1

Cyclosporin A inhibits MAPK14. 1 / 1

| 1

---

➶

reach

"In these primary human cells, CsA significantly inhibited PMA and ionomycin mediated and ionomycin mediated activation of the MAPK kinase MKK6, as well as its downstream kinases SAPK2a (p38alpha) and MAPKAP-K2."

10518804

Cyclosporin A affects JUN

| 1

Cyclosporin A inhibits JUN. 1 / 1

| 1

---

➶

reach

"CsA substantially blocked activation of nuclear factor of activated T cells and cAMP responsive element binding protein (P < 0.001), inhibited CCAAT and enhancer binding protein by 50% (P < 0.05), and minimally blocked activator protein-1 and nuclear factor-kappaB responses to bacteria in epithelial cells."

15879161

Cyclosporin A affects IFNB1

| 1

Cyclosporin A inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Cyclosporin a inhibits rotavirus replication and restores interferon-beta signaling pathway in vitro and in vivo."

23990993

Cyclosporin A affects CASP1

| 1

Cyclosporin A inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Cyclosporin A, which stabilizes mitochondria by inhibiting mitochondrial permeability transition, and knockdown of cardiolipin synthase inhibited IL-1beta secretion and caspase-1 processing by linezolid, ATP, and silica XREF_BIBR."

26432659

Cyclopentasulfur affects NLRP3

| 1

Cyclopentasulfur inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Phosphorylation of the S5 residue in the PYD of NLRP3 negatively regulates NLRP3 inflammasome activation."

29868015

Cyclopentasulfur affects JUN

| 1

Cyclopentasulfur inhibits JUN. 1 / 1

| 1

---

➶

reach

"The S5 peptide also inhibited the formation of the p38 and c-Jun signaling complex in RAW264.7 cells."

26074678

Cyclooctasulfur affects IRF3

| 1

Cyclooctasulfur inhibits IRF3. 1 / 1

| 1

---

➶

reach

"As expected, the phosphomimetic of S8 (S8E) significantly reduced IRF3 activation to about 30% of wild-type RIG-I."

28132841

Cycloheximide affects RIPK1

| 1

Cycloheximide inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"Using phospho-Ser321 as a marker, we show that the transient phosphorylation of RIPK1 intermediate domain induced by TNFalpha leads to RIPK1 independent apoptosis when NF-kappaB activation is inhibited by cycloheximide."

28842570

Cycloheximide affects RELA

| 1

Cycloheximide inhibits RELA. 1 / 1

| 1

---

➶

reach

"GR also binds other transcription factors, such as for example the p65 chain of NF-kB, AP-1 and p53 which could be involved in DEX mediated effects including anti-proliferation and activation of apoptosis.Caspase activation is inhibited by d -actinomycin and Cycloheximide, suggesting DEX induced apoptosis, like TCR triggered apoptosis, is mRNA and protein synthesis dependent."

12628752

Cycloheximide affects NFKB1

| 1

Cycloheximide inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"In line with this, LTbetaR induced p105 proteolysis and p50 nuclear translocation were also completely impaired in cells treated with cycloheximide."

25482563

Cycloheximide affects MAPK8

| 1

Cycloheximide inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"Cycloheximide attenuated the increased p-ERK, p-JNK1, and p-CaMK II levels induced by KA."

12788213

Cycloheximide affects JUN

| 1

Cycloheximide inhibits JUN. 1 / 1

| 1

---

➶

reach

"In addition, nuclear cyclic AMP responsive element (CRE) - and activator protein 1 (AP-1) DNA binding activities were increased 2 h after K+ and serum withdrawal, and these increases were inhibited by cycloheximide, Ac-DEVD-CHO and PACAP 38."

10617323

Cycloheximide affects ITCH

| 1

Cycloheximide inhibits ITCH. 1 / 1

| 1

---

➶

reach

"However, cFLIP was reported to be degraded by the enzyme Itch () when cells were treated with TNFalpha plus cycloheximide XREF_BIBR."

21533085

Cycloheximide affects IRF3

| 1

Cycloheximide inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Cycloheximide does not inhibit IRF-3 activation (Kim et al., 2002), indicating that the synthesis of virus encoded proteins is not required for this activation."

12758165

Cycloheximide affects IFNB1

| 1

Cycloheximide inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"The protein synthesis inhibitor cycloheximide (CHX) totally prevented the appearance of both IFN-alpha and IFN-beta mRNA, also in cultures supplemented with a conditioned medium (CM) assumed to contain soluble factors necessary for the IFN induction."

1666118

Cycloheximide affects FOS

| 1

Cycloheximide inhibits FOS. 1 / 1

| 1

---

➶

reach

"Negative regulatory factors have been implicated in the cycloheximide dependent synthesis of interferon, c-myc, c-fos and metallothionine and in the calcium induced gene transcription of the urokinase-type plasminogen activator [43,44]."

7857970

Cyanidin 3-O-beta-D-glucoside affects RELA

1 |

Cyanidin 3-O-beta-D-glucoside inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

26422990

Curcumin affects PYCARD

| 1

Curcumin inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Furthermore, curcumin treatment in mouse and human MM cells significantly downregulated ASC."

24431405

Curcumin affects MAP3K7

| 1

Curcumin inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"Although curcumin suppressed TAK1 and GCK activities at high concentrations, this inhibition can not fully account for the JNK inhibition by curcumin in vivo."

9674701

Cudratricusxanthone A affects RELA

| 1

Cudratricusxanthone A inhibits RELA. 1 / 1

| 1

---

➶

reach

"Moreover, CTXA inhibited the induced phosphorylation and degradation of IkappaB-alpha as well as the LPS induced increase in p65 in the nuclear fraction of macrophages."

19084080

Crotonaldehyde affects PYCARD

| 1

Crotonaldehyde inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"These finds indicated that CRD inhibited the oligomerization of ASC and caspase-1 and interfered with the function of the NLRP3 inflammasome.Studies from our group and others have shown that activation of the ERK1/2 mediated signaling pathways play an important role in modulating the expression of a variety of inflammatory mediators, including COX-2, IL-6 and TNF-alpha [20,21]."

28962083

Crotonaldehyde affects CASP1

| 1

Crotonaldehyde inhibits CASP1. 1 / 1

| 1

---

➶

reach

"These finds indicated that CRD inhibited the oligomerization of ASC and caspase-1 and interfered with the function of the NLRP3 inflammasome.Studies from our group and others have shown that activation of the ERK1/2 mediated signaling pathways play an important role in modulating the expression of a variety of inflammatory mediators, including COX-2, IL-6 and TNF-alpha [20,21]."

28962083

Crocin-1 affects NFKB1

| 1

Crocin-1 inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Crocin also inhibits Nf-kB in hepatocytes, suppresses S and G2/M phases of the cell cycle, induces apoptosis, and down-regulates inflammation in HepG2 cells."

32405344

Crocin-1 affects FOS

| 1

Crocin-1 inhibits FOS. 1 / 1

| 1

---

➶

reach

"Crocin significantly reduced the number of TUNEL positive cells in the CA1 region and decreased c-Fos in the hippocampus compared to Abeta-group."

29357117

Crocidolite asbestos affects MAPK14

1 |

Crocidolite asbestos inhibits MAPK14. 1 / 1

1 |

---

➶

ctd

No evidence text available

17507666

Crocetin affects RELA

| 1

Crocetin inhibits RELA. 1 / 1

| 1

---

➶

reach

"Crocetin significantly (p <.001) down-regulated the protein kinase C activity and the expression of nuclear factor kappaB (NF-kappaB) p65 activity and protein production in renal tissue."

31524015

Crocetin affects IKBKB

| 1

Crocetin inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Taken together, Crocetin inhibited JNK and IKKbeta activation via suppression of PKCtheta phosphorylation, attenuating insulin insensitivity induced by palmitate in 3T3-L1 adipocytes."

20541543

Creatine affects IKBKB

| 1

Creatine inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"The first NF-kappaB muscle specific knockout mouse was generated by muscle specific creatine kinase driven Cre deletion (MCK-Cre) of the IKK2 subunit [XREF_BIBR]."

18246321

Coumermycin A1 affects EIF2AK1

| 1

Coumermycin A1 inhibits EIF2AK1. 1 / 1

| 1

---

➶

reach

"The C-terminal Hsp90 inhibitors novobiocin (4) and coumermycin A1 (5) also inhibited the maturation / activation of HRI, but it was also apparent that incubation with these compounds reduced the quantity of [35 S] HRI that was present in the samples compared to the other Hsp90 inhibitors."

21486005

Coumarins affects IFIH1

| 1

Coumarins inhibits IFIH1. 1 / 1

| 1

---

➶

sparser

"Mode of helicase inhibition by coumarins."

23231076

Costunolide affects RELA

| 1

Costunolide inhibits RELA. 1 / 1

| 1

---

➶

reach

"We found that costunolide did not inhibit p65 mediated or TRAF6 mediated NF-kappaB activities in co-transfected cells."

29906743

Costunolide affects NFKB1

| 1

Costunolide inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Although, the costunolide is a major telomerase inhibitor, it is also known to the drop the intracellular glutathione (GSH) and consequently inhibits tyrosine phosphorylation of STAT3 in HepG2 and C3A [XREF_BIBR]; In addition, costunolide inhibits c-Fos and NF-kb, both related to PI3k/Akt/mTOR signaling pathway modulation; This could explain the additional effect of this molecule shown in this study."

25822740

Costunolide affects MAP3K7

| 1

Costunolide inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"Instead, these results indicated that costunolide targeted the MAPK signaling pathways.Since TAK1 is an important kinase for modulation of MAPK activation, we then determined whether costunolide inhibited TAK1 activation."

29906743

Costunolide affects FOS

| 1

Costunolide inhibits FOS. 1 / 1

| 1

---

➶

reach

"Although, the costunolide is a major telomerase inhibitor, it is also known to the drop the intracellular glutathione (GSH) and consequently inhibits tyrosine phosphorylation of STAT3 in HepG2 and C3A [XREF_BIBR]; In addition, costunolide inhibits c-Fos and NF-kb, both related to PI3k/Akt/mTOR signaling pathway modulation; This could explain the additional effect of this molecule shown in this study."

25822740

Cortisone affects PYCARD

| 1

Cortisone inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Inhibition of 11betaHSD1 within om ASC inhibits cortisone induced ASC differentiation."

10385414

Cortisol affects NFKBIA

| 1

Cortisol inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"As shown in XREF_FIG, cortisol increases CCR2 mRNA at the 12 and 24-hour timepoints, and decreases IkappaBalpha mRNA at the 6 and 12-hour time points in the CD14 + cell population (XREF_FIG)."

26790757

Cortisol affects NFKB1

| 1

Cortisol inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Hydrocortisone fails to abolish NF-kappaB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock."

25133403

Cortisol affects FOS

| 1

Cortisol inhibits FOS. 1 / 1

| 1

---

➶

reach

"Furthermore, RC significantly attenuated serum cortisol levels and up-regulated Hsp70 and c-Fos in the hippocampus."

31297904

Corticosterone affects RNF135

| 1

Corticosterone inhibits RNF135. 1 / 1

| 1

---

➶

reach

"It is well known that increases in corticosterone serum levels, induced by chronic stress or exogenous hormone administration, also reduce the number, but not affinity, of corticosteroid receptors (Sapolsky et al., 1984; Sapolsky & McEwen 1985), especially the GR ones (Reul et al., 1987)."

7838904

Corticosterone affects NFKB1

| 1

Corticosterone inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Corticosterone inhibits pineal NFKB leading to an enhancement of melatonin production, while tumor necrosis factor (TNF) leads to inhibition of Aa-nat transcription and the production of N-acetylserotonin in cultured glands."

20586888

Corilagin affects NFKB1

| 1

Corilagin inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Gallotannin inhibits NFkB signaling and growth of human colon cancer xenografts."

21532339

Copper(II) sulfide affects TANK

| 1

Copper(II) sulfide inhibits TANK. 1 / 1

| 1

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➶

reach

"CUS exposure reduces exploration of a novel tank."

32587370

Copper(2+) affects NLRP3

| 1

Copper(2+) inhibits NLRP3. 1 / 1

| 1

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➶

reach

"A clinically approved copper chelator, tetrathiomolybdate, inhibited the canonical NLRP3 but not the AIM2, NLRC4, and NLRP1 inflammasomes or NF-kappaB-dependent priming."

29358279

Copper(2+) affects IFNB1

| 1

Copper(2+) inhibits IFNB1. 1 / 1

| 1

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➶

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"The use of diethyldithiocarbamate (DETC), a copper chelating compound that inhibits SOD1 XREF_BIBR, strongly antagonized the effect of IFN-beta in infected human macrophages XREF_BIBR."

21200432

Copper atom affects IKBKB

1 |

Copper atom inhibits IKBKB. 1 / 1

1 |

---

➶

ctd

No evidence text available

19747488

Copper atom affects EIF2AK1

1 |

Copper atom inhibits EIF2AK1. 1 / 1

1 |

---

➶

ctd

No evidence text available

17689536

Colchicine affects STAT1

1 |

Colchicine inhibits STAT1. 1 / 1

1 |

---

➶

ctd

No evidence text available

28086195

Colchicine affects PYCARD

| 1

Colchicine inhibits PYCARD. 1 / 1

| 1

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➶

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"Additionally, colchicine suppresses the transport of mitochondria and subsequent approximation of ASC to NLRP3, indicating that microtubules mediated the transport of mitochondria to create optimal sites for activation of the NLRP3 inflammasome 28 ."

32251729

Coenzyme Q10 affects RELA

| 1

Coenzyme Q10 inhibits RELA. 1 / 1

| 1

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➶

reach

"However, CoQ10 treatment significantly decreased p65 and MAPK positive neurons in the DRG of DM mice."

23684663

Coenzyme Q10 affects NFKBIA

| 1

Coenzyme Q10 inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Furthermore, CoQ10 strongly suppressed H2 O2 -induced IkappaBalpha, p38 signaling pathways for osteoclastogenesis."

23582186

Coenzyme A affects CASP1

| 1

Coenzyme A inhibits CASP1. 1 / 1

| 1

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➶

reach

"We previously reported that fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, increases caspase-1 activity in PBMC."

15470035

Cocaine affects RELA

| 1

Cocaine inhibits RELA. 1 / 1

| 1

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➶

reach

"TLR3 inhibitor attenuates cocaine induced upregulation of phospho-NF-kappaB p65, IKKbeta, and p-IkappaBalpha."

29571298

Cocaine affects NLRP3

| 1

Cocaine inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Blockade of ROS (NAC) attenuated cocaine induced NLRP3 priming."

28251486

Cocaine affects NFKBIA

| 1

Cocaine inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"TLR3 inhibitor attenuates cocaine induced upregulation of phospho-NF-kappaB p65, IKKbeta, and p-IkappaBalpha."

29571298

Cocaine affects IKBKB

| 1

Cocaine inhibits IKBKB. 1 / 1

| 1

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➶

reach

"TLR3 inhibitor attenuates cocaine induced upregulation of phospho-NF-kappaB p65, IKKbeta, and p-IkappaBalpha."

29571298

Cocaine affects CHUK

| 1

Cocaine inhibits CHUK. 1 / 1

| 1

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➶

reach

"The robust inhibition of cocaine induced IKKalpha activation by BAY11-7082 was quite evident (XREF_FIG)."

25980739

Cobimetinib affects STAT1

| 1

Cobimetinib inhibits STAT1. 1 / 1

| 1

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➶

reach

"GDC-0973 treatment led to reduced pSTAT1 (Tyr701) expression in the wild-type PIK3CA cell line, A549."

27765909

Cobalt dichloride affects CASP1

| 1

Cobalt dichloride inhibits CASP1. 1 / 1

| 1

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➶

reach

"Of particular interest, CoCl2 induced hypoxic condition considerably inhibited NLRP3 dependent caspase-1 activation in mixed glial cells, but not in bone marrow derived macrophages."

24009541

Clozapine affects RELA

| 1

Clozapine inhibits RELA. 1 / 1

| 1

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➶

reach

"N3 PUFAs (DHA 8.7 muM and EPA14.21 muM) or clozapine (3muM) significantly reduced poly I : C induced increase in iNOS, NFkB (p50 and p65), IL-6 and nitrite when compared to non treated cells."

30508574

Clozapine affects NLRP3

| 1

Clozapine inhibits NLRP3. 1 / 1

| 1

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➶

reach

"We compared the profile of cytokine suppression obtained with the use of NLRP3 inflammasome inhibitor, CRID3 to that obtained with clozapine, to test our hypothesis that clozapine inhibits the NLRP3 inflammasome."

32121312

Clozapine affects NFKBIA

| 1

Clozapine inhibits NFKBIA. 1 / 1

| 1

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➶

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"We found that chronic clozapine significantly decreased IkappaBalpha (also known as Nfkbia) mRNA in mouse frontal cortex (XREF_FIG), whereas this treatment did not affect expression of other genes involved in NF-kappaB-dependent signaling (XREF_FIG)."

28783139

Clondronate(2-) affects NLRP3

| 1

Clondronate(2-) inhibits NLRP3. 1 / 1

| 1

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reach

"There are a few reports that clodronate liposome depletes macrophages and suppresses NLRP3 inflammasome activation and IL-1beta release in several disease models such as lung tumor and alcoholic hepatosteatosis."

31161887

Clofibric acid affects EIF2AK1

| 1

Clofibric acid inhibits EIF2AK1. 1 / 1

| 1

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➶

reach

"Interaction of HRI with Hsc70 was required for the transformation of HRI, as the Hsc70 antagonist clofibric acid inhibited the folding of HRI into a mature-competent conformation."

10454533

Clemastine affects NLRP3

| 1

Clemastine inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Clemastine could downregulate NLRP3 and IL-1beta and reverse hypomyelination by inhibiting the p38 signaling pathway."

32061255

Clarithromycin affects RELA

| 1

Clarithromycin inhibits RELA. 1 / 1

| 1

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➶

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"With regard to NF-kappaB levels, although telithromycin markedly suppressed p65 and p50 activity, clarithromycin suppressed only p65 activity, despite showing similar effects as telithromycin with regard to MUC5AC mRNA and protein production."

19716898

Cisplatin affects MAP3K7

| 1

Cisplatin inhibits MAP3K7. 1 / 1

| 1

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➶

reach

"Then, we applied a TAK1 overexpression vector to reverse authenticate the effect of TAK1 on cell autophagy using renal tubular epithelial cells treated with cisplatin invitro."

29504713

Cisplatin affects IFNB1

| 1

Cisplatin inhibits IFNB1. 1 / 1

| 1

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"As shown in XREF_FIG B, knockout of IRF1 attenuated the cell viability inhibition by cisplatin with or without IFNbeta pretreatment."

32326356

Cisplatin affects FOS

| 1

Cisplatin inhibits FOS. 1 / 1

| 1

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"Our results show dose dependent reductions in food intake and body weight following cisplatin treatment, as well as increases in cisplatin induced c-Fos in the PBN and throughout the DVC."

24582677

Cisplatin affects CASP1

| 1

Cisplatin inhibits CASP1. 1 / 1

| 1

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"Blocking of p73 function by a dominant negative mutant reduced basal as well as cisplatin induced caspase-1 promoter activity."

16135520

Cinacalcet affects NLRP3

| 1

Cinacalcet inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Upstream ERK pathway inhibition decreased cinacalcet dependent activation of NLRP3 inflammasome."

29345311

Cimetidine affects ITCH

| 1

Cimetidine inhibits ITCH. 1 / 1

| 1

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➶

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"The H2-antagonists cimetidine and metiamide reduced flare and itch significantly but not to the same extenet as mepyramine and not in a clearly dose related manner."

92142

Cilostazol affects NLRP3

| 1

Cilostazol inhibits NLRP3. 1 / 1

| 1

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➶

reach

"We found that cilostazol significantly reduced NLRP3 inflammasome activation, as well as the activity of other related and harmful factors, including oxidative stress, expression of NADPH oxidase 4 (NOX-4), thioredoxin interacting protein (TxNIP), high mobility group box 1 (HMGB-1), interleukin 1beta (IL-1beta) and IL-18."

31514535

Cilostazol affects MAPK14

| 1

Cilostazol inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Cilostazol protected Human umbilical vein endothelial cells against lipopolysaccharide-induced apoptosis by suppressing the mitochondrial permeability transition, cytosolic release of cytochrome c, and subsequent activation of caspases, stimulating extracellullar signal-regulated kinase (ERK1/2) and p38 mitogen-activated protein kinase signaling, and increasing phosphorylated cAMP-responsive element-binding protein (CREB) and Bcl-2 expression, while suppressing Bax expression."

19543489

Cilostazol affects JUN

| 1

Cilostazol inhibits JUN. 1 / 1

| 1

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➶

reach

"Phosphorylated NF-kappaB, but not c-Jun and c-Fos, was also downregulated by cilostazol treatment in UVB irradiated mice."

27484958

Cilostazol affects FOS

| 1

Cilostazol inhibits FOS. 1 / 1

| 1

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➶

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"Phosphorylated NF-kappaB, but not c-Jun and c-Fos, was also downregulated by cilostazol treatment in UVB irradiated mice."

27484958

Ciguatoxin CTX1B affects NLRP3

| 1

Ciguatoxin CTX1B inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Our results suggest that PQQ protects against CTX induced nephrotoxicity, probably by activating the Nrf2 mediated antioxidant pathway and inhibiting the NLRP3 inflammatory pathway."

32504759

Ciguatoxin CTX1B affects NFKBIA

| 1

Ciguatoxin CTX1B inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"CTX treatment decreased the ratio of p-IkappaB-alpha to IkappaB-alpha."

26640497

Ciglitazone affects RELA

1 |

Ciglitazone inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

17425601

Ciglitazone affects NFKB1

1 |

Ciglitazone inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

17425601

Chrysin affects TBK1

1 |

Chrysin inhibits TBK1. 1 / 1

1 |

---

➶

ctd

No evidence text available

19426678

Chromium atom affects NLRP3

| 1

Chromium atom inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Pterostilbene Attenuates Hexavalent Chromium Induced Allergic Contact Dermatitis by Preventing Cell Apoptosis and Inhibiting IL-1beta-Related NLRP3 Inflammasome Activation."

30486377

Chondroitin sulfate affects IFIH1

| 1

Chondroitin sulfate inhibits IFIH1. 1 / 1

| 1

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➶

sparser

"Our findings suggest that CS may inhibit NS3 helicase not by abolishing the other NS3 activities but by inducing conformational changes via interaction with possible allosteric sites of NS3."

23432541

Choline affects NLRP3

| 1

Choline inhibits NLRP3. 1 / 1

| 1

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➶

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"However, substitution of extracellular Na + with choline did not impair K + efflux or NLRP3 activation elicited by ATP (XREF_FIG C), aerolysin, Al (OH) 3 and silica (XREF_FIG and XREF_SUPPLEMENTARY)."

23809161

Choline affects NFKB1

| 1

Choline inhibits NFKB1. 1 / 1

| 1

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➶

reach

"These authors also observed that the anti-inflammatory effects of choline occurred in response to choline stimulating alpha7nACh receptors and subsequently suppressing NF-KB activity and therefore production of pro inflammatory messengers."

29563868

Cholesterol affects STAT1

| 1

Cholesterol inhibits STAT1. 1 / 1

| 1

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➶

reach

"Furthermore, when STAT3 and STAT1-EGFP expressed cells were treated with MCD, a cholesterol sequestrating agent, the IL-6-induced STAT1 and STAT3 nuclear translocation was blocked."

25781885

Cholesterol affects NFKB1

| 1

Cholesterol inhibits NFKB1. 1 / 1

| 1

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➶

reach

"In our experiments, OX40 translocated into DIM after interaction with OX40L and although we found that the interaction between OX40 and the TRAF2-IKK compartment was independent of DIM, depletion of cholesterol or suppression of synthesis of sphingolipid and cholesterol strongly inhibited OX40 dependent NF-kappaB1 activation."

22654884

Cholesterol affects ITCH

| 1

Cholesterol inhibits ITCH. 1 / 1

| 1

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➶

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"Either inhibition of caveolin dependent membrane protein internalization by cholesterol oxidase or silencing E3 ubiquitine ligase Itch by small interfering RNA could partially counteract the effects of Aroclor1254 on the barrier function of cultured SCs."

28542131

Cholesterol affects IFNAR1

| 1

Cholesterol inhibits IFNAR1. 1 / 1

| 1

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"In this study, supplementation of infected cells with cholesterol replenished plasma membrane localized cholesterol and partially rescued cellular responses to IFN-I simulation suggesting that cholesterol sequestration may disrupt IFNAR1 localization."

26159719

Cholesterol affects CASP1

| 1

Cholesterol inhibits CASP1. 1 / 1

| 1

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➶

reach

"Collectively, these results demonstrate that restoration of cholesterol levels during the second signal of inflammasome activation reduces inflammasome assembly, caspase-1 activation, and IL-1beta production in cells deficient in lipin-2."

28031477

Cholest-5-en-3-ol affects NFKB1

| 1

Cholest-5-en-3-ol inhibits NFKB1. 1 / 1

| 1

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➶

reach

"The clinical implication of these findings is that treatment of CF patients with small molecule or therapeutic compounds that rescues optimal amount of mutant CFTR to the cholestrol rich cell surface lipid rafts can inhibit the NFkB mediated chronic inflammation and rescue the pathology induced by defective CFTR, potentially attenuating the progression of CF or related obstructive lung diseases like COPD and emphysema."

20205681

Cholest-5-en-3-ol affects CASP1

| 1

Cholest-5-en-3-ol inhibits CASP1. 1 / 1

| 1

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➶

reach

"Cholesterol depletion in the ER membranes abrogates casp-1 activation and IL-1beta secretion."

30054450

Chlorpyrifos affects STAT1

| 1

Chlorpyrifos inhibits STAT1. 1 / 1

| 1

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➶

reach

"Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity : Implications for mitochondria mediated oxidative stress signaling events."

29859868

Chlorpromazine affects RIPK1

| 1

Chlorpromazine inhibits RIPK1. 1 / 1

| 1

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➶

reach

"Chlorpromazine reversal of RIP induced liver toxicity To evaluate the relative contribution of liver or kidney toxicity to the mortality, PAP-S was used because of its lower Luso."

8707448

Chloroxine affects NFKB1

| 1

Chloroxine inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Neither NrL.Cl nor CHQ were able to block NF-KB in- duction efficiently by LPS (Figs. 5C, D)."

9065737

Chloroquine affects TICAM1

| 1

Chloroquine inhibits TICAM1. 1 / 1

| 1

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➶

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"Chloroquine (CQ) has been shown to affect LPS-TLR4 colocalization and inhibit both MyD88 dependent and TRAM and TRIF dependent pathways, though the mechanism involved is still poorly understood."

28134560

Chloroform affects TRAF3

| 1

Chloroform inhibits TRAF3. 1 / 1

| 1

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"However, Tcm cells (CD44 hi CD62L hi) were reduced 5-10 fold in the absence of TRAF3 (XREF_FIG)."

25010048

Chloroform affects RIPK1

| 1

Chloroform inhibits RIPK1. 1 / 1

| 1

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➶

reach

"Cf reduced RIPK1 modification, as well as the association of FADD and P42-Casp8 with DRMs, suggesting proteasome activity contributes to DRM associated ripoptosome composition."

29497034

Chloroethene affects PYCARD

| 1

Chloroethene inhibits PYCARD. 1 / 1

| 1

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➶

reach

"Furthermore, the combinatorial use of SE and VC improved osteogenic ECM rich cell sheet formation and prevented senescence of ASC derived osteogenic cell sheets."

30960193

Chloramphenicol affects TRIM25

| 1

Chloramphenicol inhibits TRIM25. 1 / 1

| 1

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➶

reach

"Despite this cost in fitness, these mutants are not more susceptible to a wide range of antibiotics; including ribosome targeting antibiotics, such as lincomycin, chloramphenicol, and streptomycin, which have been shown previously to disrupt EF-P function in vitro."

23591475

Chloramphenicol affects RELA

| 1

Chloramphenicol inhibits RELA. 1 / 1

| 1

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"We have tested antibiotics tetracycline and chloramphenicol that inhibit translation and have been reported to abrogate RelA mediated ppGpp accumulation in live bacteria."

28115345

Chloramphenicol affects NFKBIA

| 1

Chloramphenicol inhibits NFKBIA. 1 / 1

| 1

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"This inhibitory effect required bacterial protein synthesis as the level of IkappaBalpha phosphorylation was restored in C. pneumoniae infected cells treated with chloramphenicol (XREF_FIG)."

19159390

Chloramphenicol affects MAVS

| 1

Chloramphenicol inhibits MAVS. 1 / 1

| 1

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"Against MRSA thiamphenicol and chloramphenicol were second only to the glycopetides and also inhibited the VISA strains."

12583545

Chloramphenicol affects IFNB1

| 1

Chloramphenicol inhibits IFNB1. 1 / 1

| 1

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➶

medscan

"Further, addition of chloramphenicol to block chlamydial growth after inclusion formation abrogates IFNβ expression, confirming the consistent requirement of bacterial growth ( )."

25070851

Chitosan affects NLRP3

| 1

Chitosan inhibits NLRP3. 1 / 1

| 1

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➶

reach

"3D chitosan scaffolds impair NLRP3 inflammasome response in macrophages."

31003033

Chitosan affects NFKBIA

| 1

Chitosan inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"The sulfated chitosan oligosaccharides also suppressed inducible nitric oxide synthase (iNOS), phosphorylation of JNK and translocation of p65, a subunit of NF-kappaB, into the nucleus by inhibiting degradation of IkappaB-alpha."

25387351

Chenodeoxycholic acid affects JUN

| 1

Chenodeoxycholic acid inhibits JUN. 1 / 1

| 1

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➶

reach

"In conclusion, IL-1 beta and CDCA inhibit HNF4 alpha but induce c-Jun, which in turn blocks HNF 4 alpha recruitment of PGC-1 alpha to the CYP7A1 chromatin and results in inhibition of CYP7A1 gene transcription."

16729332

Chenodeoxycholic acid affects CASP1

| 1

Chenodeoxycholic acid inhibits CASP1. 1 / 1

| 1

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➶

reach

"Caspase-1 inhibitor could significantly impair the IL-1beta secretion induced by CDCA, which further reveal that CDCA activates caspase-1 in macrophages, leading to IL-1beta release."

27924062

Chelerythrine affects MAPK8

| 1

Chelerythrine inhibits MAPK8. 1 / 1

| 1

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➶

reach

"Interestingly, pretreatment with the antioxidants, N-acetyl-L-cysteine, dithiothreitol, and glutathione, impaired chelerythrine induced JNK1 and p38 activation."

10734112

Chelerythrine affects JUN

| 1

Chelerythrine inhibits JUN. 1 / 1

| 1

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➶

reach

"The c-jun and c-fos mRNA stimulation elicited by TPA was reduced by the PKC inhibitors, chelerythrine and staurosporine, and could not be mimicked by 4alpha-phorbol 12,13-didecanoate (a phorbol ester that fails to activate PKC), whereas the stimulation induced by EGF was diminished by the PTK inhibitor, genistein."

9177393

Cetrorelix affects RELA

1 |

Cetrorelix inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

21062912

Ceruletide affects TRAF6

| 1

Ceruletide inhibits TRAF6. 1 / 1

| 1

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➶

reach

"We found that while treatment of 2muM caerulein alone increased the levels of Traf6 expression significantly, the combination of 2muM caerulein and 1muM LPS suppressed the activation of Traf6 by caerulein (XREF_FIG)."

26633718

Ceruletide affects STAT2

| 1

Ceruletide inhibits STAT2. 1 / 1

| 1

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➶

reach

"Inhibition of TNFalpha improved (inhibition of IL-10 worsened) caerulein induced pancreatitis in WT but not Stat2 -/- mice."

32506441

Ceruletide affects NFKB1

| 1

Ceruletide inhibits NFKB1. 1 / 1

| 1

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➶

reach

"The inhibition of JAK-1 and STAT-1 improves the severity of cerulein stimulated pancreatic injury by inhibiting the activation of NFkB, and this indicates that activation of JAK-1 and STAT-1 is involved in the early events of pancreatic injury [XREF_BIBR]."

28217371

Ceritinib affects CASP1

| 1

Ceritinib inhibits CASP1. 1 / 1

| 1

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➶

reach

"Ceritinib and lorlatinib inhibited CASP1 activation, LDH release, and IL-1beta release in BMDMs."

29723525

Ceramide affects NFKBIA

| 1

Ceramide inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Rebamipide inhibited the ceramide induced degradation of IkappaB-alpha (a major cytoplasmic inhibitor of nuclear factor-kappaB), further supporting that rebamipide inhibits the activation of nuclear factor-kappaB."

11454909

Ceramide affects NFKB1

| 1

Ceramide inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Kronke and co- workers (Schutze et al., 1992; Machleidt et al., 1994) demonstrated that exogenous sphingomyelinase and synthetic ceramide induced degradation of IKB, the physiologic inhibitor of NF-KB, and NFxB activation using permeabilized preparations of Jurkat T cells."

8181053

Celecoxib affects NFKBIA

| 1

Celecoxib inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Furthermore, celecoxib attenuated the activation of phospho-IkappaBalpha and NF-kappaB in CS treated rat lung."

20472710

Celecoxib affects NFKB1

| 1

Celecoxib inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Indomethacin and celecoxib differentially modulated expression of osteoclastogenic and other bone metabolism genes : celecoxib downregulated Igf1r, Ctsk, Mmp9, Cd36, Icam1, Nfkb1, Smad3, Sox9, Csf3, Vcam1 and Itga3 whereas indomethacin inhibited Tgfbr1, Igf1r, Ctsk, Mmp9, Sox9, Cd36 and Icam1."

31166414

Celecoxib affects MAPK8

| 1

Celecoxib inhibits MAPK8. 1 / 1

| 1

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➶

reach

"Celecoxib treatment significantly reduced the IOD of Wnt5a and JNK1 in the T2DM-NASH-Cele group (XREF_FIG)."

24404139

Celecoxib affects MAPK14

1 |

Celecoxib inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

15990304

Celecoxib affects IKBKB

| 1

Celecoxib inhibits IKBKB. 1 / 1

| 1

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➶

reach

"Also, we found that long term celecoxib treatment inhibited IKKbeta activity (XREF_FIG), a result consistent with the essential role of enterocyte-intrinsic IKKbeta expression in maintaining intestinal homeostasis."

20484034

Celecoxib affects FOS

| 1

Celecoxib inhibits FOS. 1 / 1

| 1

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➶

reach

"Consequently, the mRNA expression of hepatic hypoxia inducible factor-1alpha (HIF-1alpha), one of the downstream molecules of PGE2 and stimulator of VEGF, was significantly increased in TAA group when compared with that in control group, but was greatly decreased by the celecoxib treatment, p < 0.01 (XREF_FIG,) In addition, hepatic p-ERK and c-fos pathway, a link between ERK and VEGF, was greatly activated in TAA model (p < 0.01), but was suppressed by the addition of celecoxib (p < 0.01)."

23922700

Celastrol affects PYCARD

| 1

Celastrol inhibits PYCARD. 1 / 1

| 1

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➶

reach

"Moreover, celastrol treatment markedly decreased mRNA expression caspase-1, NLRP3 and ASC in colon tissue."

28978034

Celastrol affects MAPK8

| 1

Celastrol inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"Celastrol decreased HIV-1 Tat-induced activation of JNK MAPK, AP-1, and NF-κB."

25064159

Celastrol affects JUN

| 1

Celastrol inhibits JUN. 1 / 1

| 1

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➶

reach

"Of importance, inhibiting NOX2 with apocynin or silencing NOX2 by RNA interference enhanced the inhibitory effects of celastrol on Cd induced inactivation of PP5, activation of JNK and c-Jun, ROS and apoptosis in the cells."

28129433

Celastrol affects IRF3

| 1

Celastrol inhibits IRF3. 1 / 1

| 1

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➶

reach

"Here we showed that celastrol caused inhibition of interferon regulatory factor 3 (IRF3) activation leading to the down-regulation of the interferon response triggered by cytosolic nucleic acids in vitro and in vivo."

32565148

Cefmetazole sodium affects TANK

| 1

Cefmetazole sodium inhibits TANK. 1 / 1

| 1

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➶

reach

"Cascade utilization of organic matters made the CSMER remove a wider range of substrates compared with a continuous stirred tank reactor (CSTR), in which process 79.1 +/-5.6% of soluble protein and 86.6 +/-2.2% of soluble carbohydrates were degraded by anaerobic digestion in the CMZ and short-chain volatile fatty acids were further decomposed and generated current in the MEZ."

27270788

Cefaclor affects RELA

| 1

Cefaclor inhibits RELA. 1 / 1

| 1

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➶

reach

"As a result, a remarkable increase of the NF-kappaB p65 expression in the nuclear fraction and simultaneously a decrease of NF-kappaB p65 expression in the cytoplasmic fraction were found in rats treated with CCl 4."

32425800

Cation affects JUN

| 1

Cation inhibits JUN. 1 / 1

| 1

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➶

sparser

"A calcium-dependent cyclic nucleotide phosphodiesterase from rat cerebrum was, in the absence of activator protein, inhibited by various monovalent cations."

214428

Cation affects EIF2AK1

| 1

Cation inhibits EIF2AK1. 1 / 1

| 1

---

➶

sparser

"A potential mechanism for the metal cations-induced inhibition of HRI is that the cations compete with the heme in binding Cys or His and inhibits HRI by forming an inactive Mt 2+ -HRI complex ( xref )."

21463677

Catechin affects CASP1

| 1

Catechin inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Catechins and Sialic Acid Attenuate Helicobacter pylori Triggered Epithelial Caspase-1 Activity and Eradicate Helicobacter pylori Infection."

23653660

Casticin affects RELA

| 1

Casticin inhibits RELA. 1 / 1

| 1

---

➶

medscan

"The NF-κB p65 and p-ERK levels in nuclear proteins are also decreased by treatment with casticin."

27007357

Carvedilol affects RELA

| 1

Carvedilol inhibits RELA. 1 / 1

| 1

---

➶

reach

"Notably, hypoxia resulted in a significant nuclear translocation of NF-kappaB p65, which was inhibited by administration of carvedilol."

28821450

Carvedilol affects JUN

| 1

Carvedilol inhibits JUN. 1 / 1

| 1

---

➶

reach

"We have previously shown that carvedilol could directly inhibit the activation of redox sensitive transcription factor AP-1 and NF-eB in TNF-alpha-stimulated human aortic endothelial cells [27]."

17964422

Carnosine affects RELA

| 1

Carnosine inhibits RELA. 1 / 1

| 1

---

➶

reach

"Carnosine significantly decreased serum alanine aminotransferase, and hepatic lipid peroxidation, nitric oxide, tumor necrosis factor-alpha, and nuclear factor-kappaB p65 unit, and significantly increased liver total antioxidant status in TCA challenged rats."

28863318

Cardenolide affects JAK1

| 1

Cardenolide inhibits JAK1. 1 / 1

| 1

---

➶

eidos

"Our finding that cardenolides caused JAK1 diminishment via activation of NEDD4 suppress coronaviral replication bolsters that the NEDD4 associated JAK1 degradation is a candidate subject for the development of a novel PROTAC ; and therapeutic applications could be explored based on the property of JAK1 diminishment / inhibition of the cardenolides as antivirals ."

| PMC

Carbon monoxide affects TICAM1

| 1

Carbon monoxide inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"Although ST2 suppresses TLR4 signaling by sequestration of the adaptor protein MyD88 and Mal, but not TRIF, CO inhibited the LPS induced interaction of TLR4 and TRIF as well as of TLR4 and MyD88."

17000866

Carbon monoxide affects STAT1

| 1

Carbon monoxide inhibits STAT1. 1 / 1

| 1

---

➶

reach

"CO also significantly inhibited I/R injury induced STAT1 and STAT3 activation."

18006605

Carbon monoxide affects PYCARD

| 1

Carbon monoxide inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Since administration of the HO-effector molecule CO also attenuated H 2 O 2 -induced ASC death, it is likely that CO mediates in part the protective effects of HO-1 induction."

25299695

Carbon monoxide affects NFKB1

| 1

Carbon monoxide inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"The generated CO effectively suppresses the secretion of interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha by inhibiting cell proliferation; inducing the activation of heme oxygenase (HO-1), and downregulating the expression of p38 MAPK, NF-kB (p50 and p65) and TLR-2."

32554130

Carbon monoxide affects MYD88

| 1

Carbon monoxide inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Although ST2 suppresses TLR4 signaling by sequestration of the adaptor protein MyD88 and Mal, but not TRIF, CO inhibited the LPS induced interaction of TLR4 and TRIF as well as of TLR4 and MyD88."

17000866

Carbon monoxide affects IFNB1

| 1

Carbon monoxide inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"In the same study, although CO inhibited TLR4 signaling and subsequent IFN-beta production after LPS stimulation, it did not affect TLR3 dependent signaling in macrophages in response to polyI : C treatment."

19398754

Carbon monoxide affects FOS

| 1

Carbon monoxide inhibits FOS. 1 / 1

| 1

---

➶

reach

"Our earlier studies on postnatal CO-exposure showed that chronic mild CO exposure permanently decreases basal c-fos in another region of the brain, the central nucleus of the inferior colliculus [XREF_BIBR, XREF_BIBR], a condition that can be prevented by the dietary reduction of iron without anaemia [XREF_BIBR]."

19580685

Carbachol affects NFKBIA

| 1

Carbachol inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Carbachol also induced degradation of IkappaBalpha, which was reversed by addition of both GF109203X and PDTC and stimulated the activity of a NF-kappaB-luciferase reporter gene plasmid in COS-7 cells stably expressing the human M3 muscarinic receptor."

10441519

Captopril affects FOS

| 1

Captopril inhibits FOS. 1 / 1

| 1

---

➶

reach

"Given that increased c-Fos immunoreactivity in the lamina terminalis following isoproterenol administration is abolished by the AT 1 receptor blocker losartan or the ACE inhibitor captopril it is recognized that circulating AngII is responsible for activation of the lamina terminalis after drug administration as opposed to vascular responses."

20092577

Capsaicin affects STAT1

| 1

Capsaicin inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Knockdown of NOX3 in UB/OC1 cells attenuated the activation of STAT-1 by capsaicin."

22562580

Capsaicin affects RELA

1 |

Capsaicin inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

17719033

Capsaicin affects MAPK8

| 1

Capsaicin inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"Furthermore, capsaicin significantly reduced palmitate-stimulated activation of c-Jun N-terminal kinase, c-Jun, and p38."

21745629

Capsaicin affects FOS

| 1

Capsaicin inhibits FOS. 1 / 1

| 1

---

➶

reach

"In contrast, the hypothalamic pituitary c-fos activation provoked by immobilization stress though markedly decreased, was not abolished by capsaicin, whereas plasma release of adrenocorticotropic hormone remained undiminished."

9174074

Cantharidin affects MAPK8

| 1

Cantharidin inhibits MAPK8. 1 / 1

| 1

---

➶

sparser

"We further found that cantharidin inhibited the p-JNK1/2 and p-p38."

23431332

Calyculin A affects RELA

1 |

Calyculin A inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

12853972

Calycosin affects NFKBIA

| 1

Calycosin inhibits NFKBIA. 1 / 1

| 1

---

➶

sparser

"The calycosin (50 mg/kg) and 5-ASA inhibited the phosphorylation of IKKα/β, IκBα and p65 to attenuate the inflammation, which was consistent with the suppression of mRNA expressions ( xref )."

29085602

Calcium(2+) affects TRIM25

| 1

Calcium(2+) inhibits TRIM25. 1 / 1

| 1

---

➶

reach

"Upon application of non NMDA glutamate subreceptor blocker the EFP were abolished in all trials, while application of the organic calcium channel blocker verapamil only suppressed the EFP in some cases."

11454323

Calcium(2+) affects TLR7

| 1

Calcium(2+) inhibits TLR7. 1 / 1

| 1

---

➶

reach

"In addition, calcium depletion via EDTA in combination with the calcium ionophore A23187 also reduced cleavage of TLR7 and selectively impaired the response of THP-TLR7 to R837 but not to LPS."

24138882

Calcium(2+) affects TBK1

| 1

Calcium(2+) inhibits TBK1. 1 / 1

| 1

---

➶

reach

"Transient Ca elevations attenuate Na/K pump current decay by mechanisms that remain to be elucidated."

27627745

Calcium(2+) affects STING1

| 1

Calcium(2+) inhibits STING1. 1 / 1

| 1

---

➶

reach

"Relapsing anaphylaxis to bee sting in a patient treated with beta-blocker and Ca blocker."

2312997

Calcium(2+) affects MAPK8

| 1

Calcium(2+) inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"Arecoline-elicited increase in intracellular Ca(2+) concentration was responsible for JNK/c-Jun pathway activation and ERK inactivation."

21809341

Calcium(2+) affects MAP3K7

| 1

Calcium(2+) inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"Extracellular (EGTA) or intracellular (BAPTA/AM) Ca (2+) chelator prevented the stretch induced activation of TAK1."

21371434

Calcium(2+) affects JUN

| 1

Calcium(2+) inhibits JUN. 1 / 1

| 1

---

➶

medscan

"Arecoline-elicited increase in intracellular Ca(2+) concentration was responsible for JNK/c-Jun pathway activation and ERK inactivation."

21809341

Calcium(2+) affects ITCH

| 1

Calcium(2+) inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Specifically, thiazides and calcium channel blockers have been known to cause itch in elderly patients."

25693757

Calcium(2+) affects IKBKB

| 1

Calcium(2+) inhibits IKBKB. 1 / 1

| 1

---

➶

sparser

"In the cell free hotspot kinase assay, the CA, AA and UA inhibited human IKKβ."

25938234

Calcium dichloride affects FOS

| 1

Calcium dichloride inhibits FOS. 1 / 1

| 1

---

➶

reach

"Immunohistochemistry study indicated that application of CaCl2 (25 or 50nmol) in the DRN significantly increased c-Fos expression ratio in wake promoting neurons including serotonergic neurons in the DRN, noradrenergic neurons in the locus coeruleus, and orxinergic neurons in the perifornical nucleus, but decreased c-Fos expression ratio of GABAergic sleep promoting neurons in the ventrolateral preoptic nucleus."

27456222

Calcium atom affects IRF3

| 1

Calcium atom inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Calcium disruption (as through the SERCA pump inhibitor thapsigargin) and oxygen glucose deprivation activate IRF3 through a STING dependent mechanism, whereas agents that disrupt N linked glycosylation (e.g., tunicamycin) appear to utilize a STING independent, but Site-1 and Site-2 protease (ATF6?)"

29556237

Calcium atom affects CASP1

| 1

Calcium atom inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Calcium removal blocks caspase-1 activation."

25048991

Calcitriol affects MAPK8

1 |

Calcitriol inhibits MAPK8. 1 / 1

1 |

---

➶

ctd

No evidence text available

12761878

Calcitriol affects JUN

| 1

Calcitriol inhibits JUN. 1 / 1

| 1

---

➶

reach

"1,25-Dihydroxyvitamin D3 inhibits ultraviolet B induced apoptosis, Jun kinase activation, and interleukin-6 production in primary human keratinocytes."

12858333

Caffeine affects MAPK14

| 1

Caffeine inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway."

20432471

Caffeine affects JUN

| 1

Caffeine inhibits JUN. 1 / 1

| 1

---

➶

medscan

"Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway."

20432471

Cadmium(2+) affects PYCARD

| 1

Cadmium(2+) inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Cadmium (Cd) stress significantly decreased membrane integrity and impaired the ascorbate (ASC)-glutathione (GSH) cycle in tobacco Bright Yellow-2 cells."

19809168

Cadmium(2+) affects JAK1

| 1

Cadmium(2+) inhibits JAK1. 1 / 1

| 1

---

➶

reach

"We found that divalent cadmium (CdCl2) inhibited ciliary neurotrophic factor (CNTF)-mediated Jak1 and Jak2 tyrosine kinase signaling in human BE (2)-C neuroblastoma cells."

16843830

Cadmium(2+) affects EIF2AK1

| 1

Cadmium(2+) inhibits EIF2AK1. 1 / 1

| 1

---

➶

reach

"Limited heme availability or heavy metals like cadmium activate HRI."

25480292

Cadmium dichloride affects NFKB1

| 1

Cadmium dichloride inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"On the other hand, cadmium chloride strongly reduced DNA binding activity of all forms in both resting and antigen stimulated lymphocytes.Exposure to 10 muM of orthovanadate increased the inducible p50 and p65 form of NF-kappaB in resting, but not in antigen stimulated splenocytes."

11696409

Cadmium dichloride affects JAK1

| 1

Cadmium dichloride inhibits JAK1. 1 / 1

| 1

---

➶

reach

"We found that divalent cadmium (CdCl2) inhibited ciliary neurotrophic factor (CNTF)-mediated Jak1 and Jak2 tyrosine kinase signaling in human BE (2)-C neuroblastoma cells."

16843830

Cadmium dichloride affects CHUK

1 |

Cadmium dichloride inhibits CHUK. 1 / 1

1 |

---

➶

ctd

No evidence text available

16478757

Cadmium atom affects RELA

1 |

Cadmium atom inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

16478757

Cadmium atom affects NLRP3

| 1

Cadmium atom inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Accordingly, pre-treatment with mtROS scavenger or total ROS scavenger reduced Cd induced activation of NLRP3 inflammasome and pyroptotic cell death."

26809137

Cadmium atom affects IKBKB

| 1

Cadmium atom inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"This corresponded with Cd mediated inhibition of IKKbeta and an impaired ability to transcribe and release cytokines in response to LPS challenge in vivo."

27496894

Cadmium atom affects IFIH1

| 1

Cadmium atom inhibits IFIH1. 1 / 1

| 1

---

➶

sparser

"The corresponding IC 50 values were compatible with values derived from DNA-binding inhibition curves suggesting that the Cd 2+ -dependent inhibition of helicase and ATPase activities could be explained in part by inhibition of the DNA-binding step."

27194376

Cadmium atom affects EIF2AK1

1 |

Cadmium atom inhibits EIF2AK1. 1 / 1

1 |

---

➶

ctd

No evidence text available

17689536

Cadmium atom affects CHUK

1 |

Cadmium atom inhibits CHUK. 1 / 1

1 |

---

➶

ctd

No evidence text available

16478757

Butyric acid affects FOS

| 1

Butyric acid inhibits FOS. 1 / 1

| 1

---

➶

reach

"An example from this current study is the regulatory network controlled by FBJ murine osteosarcoma viral oncogene homolog, or c-fos (FOS), which was significantly down-regulated by butyrate in both in vitro and in vivo models."

22654504

Butein affects NFKBIA

| 1

Butein inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Indeed, Pandey et al [XREF_BIBR] demonstrated that butein (3,4,2 ',4 '-tetrahydroxy chalcone) inhibited NF-kappaB and NF-kappaB regulated gene expression through its conjugation of cysteine 179 residue of the IKKbeta and then stabilization of IkBalpha protein."

24467530

Butein affects JUN

| 1

Butein inhibits JUN. 1 / 1

| 1

---

➶

reach

"Electrophoretic mobility shift assay revealed that butein blocked activation of transcription factors, nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), induced by TNF-alpha and PMA."

25533502

Butein affects IKBKB

| 1

Butein inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Pandey et al. [XREF_BIBR] found that anticancer and anti-inflammatory natural chalcone compound 19 (butein) directly inhibited IKKbeta activity both biochemically and in cells, and subsequently reduced the downstream products of NF-kappaB activation, resulting in elevated apoptosis induced by TNF and other chemotherapeutic agents."

26798565

Buspirone affects TANK

| 1

Buspirone inhibits TANK. 1 / 1

| 1

---

➶

reach

"The novel tank diving response is reduced by anxiolytic drugs diazepam and buspirone, but not by chlordiazepoxide [XREF_BIBR]."

20359493

Bumetanide affects FOS

| 1

Bumetanide inhibits FOS. 1 / 1

| 1

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➶

reach

"Amiloride and bumetanide, when added separately or in combination, did not inhibit the induction of c-fos, c-myc, and ODC mRNAs."

2472417

Bufalin affects MAPK8

1 |

Bufalin inhibits MAPK8. 1 / 1

1 |

---

➶

ctd

No evidence text available

21922632

Bufalin affects JAK1

| 1

Bufalin inhibits JAK1. 1 / 1

| 1

---

➶

eidos

"Strikingly , whereas the natural cardenolides and bufalin ( a bufadienolide ) could induce significant JAK1 diminishment , the two innovative Na + / K + - ATPase effectors istaroxin ( an inhibitor ) and rostafuroxin ( a modulator ) [ 21 ] , [ 22 ] examined herein ( Figure 4D ) could not ."

| PMC

Bufadienolide affects JAK1

| 1

Bufadienolide inhibits JAK1. 1 / 1

| 1

---

➶

eidos

"Strikingly , whereas the natural cardenolides and bufalin ( a bufadienolide ) could induce significant JAK1 diminishment , the two innovative Na + / K + - ATPase effectors istaroxin ( an inhibitor ) and rostafuroxin ( a modulator ) [ 21 ] , [ 22 ] examined herein ( Figure 4D ) could not ."

| PMC

Budesonide affects RELA

| 1

Budesonide inhibits RELA. 1 / 1

| 1

---

➶

reach

"Formoterol and budesonide reduced the activation of the nuclear factor kappa-B protein p65 in nuclear extracts."

24998372

Budesonide affects IFNB1

| 1

Budesonide inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Administration of 20mug of budesonide similarly suppressed RV induction of lung IFNbeta and IFNlambda2/3 and increased RV RNA (Supplementary Fig1a-d)."

29884817

Bucladesine affects RELA

| 1

Bucladesine inhibits RELA. 1 / 1

| 1

---

➶

reach

"Furthermore, dibutyryl cAMP decreased the interaction of the p65 nuclear factor-kappa B with CREB binding protein, thus further inhibiting CT105 mediated TNF-alpha expression."

12606779

Bryostatin 1 affects NLRP3

| 1

Bryostatin 1 inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In contrast, NLRP3 inflammasome activation induced by ATP, AIM2 inflammasome activation induced by double stranded DNA, and NLRC4 inflammasome activation induced by flagellin were not suppressed by bryostatin 1 (XREF_SUPPLEMENTARY)."

27270401

Brefeldin A affects NFKBIA

| 1

Brefeldin A inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"A marked decrease of IkappaBalpha was detected in the MCF-7 cells treated with brefeldin A (XREF_FIG), and the corresponding increase in the nuclear localization of NF-kappaB (p50 and p65) was also been seen in the treated cells within a similar time frame (XREF_FIG)."

22859938

Brefeldin A affects JUN

| 1

Brefeldin A inhibits JUN. 1 / 1

| 1

---

➶

sparser

"Using the software packages geNorm, NormFinder, BestKeeper and refFinder, three traditionally used reference genes, β -actin ( β-ACT ), glyceraldehyde-3-phosphate dehydrogenase ( GAPDH ), and beta-2-microglobulin ( B2M ), were identified as not suitable for E . akaara gene expression studies, whereas two newly identified reference genes, conserved oligomeric Golgi complex subunit 5 ( Cog5 ) and brefeldin a-inhibited guanine nucleotide-exchange protein 1 ( ARFGEF1 ), could be universally applied under all the tested conditions."

28182746

Bradykinin affects IRF7

| 1

Bradykinin inhibits IRF7. 1 / 1

| 1

---

➶

reach

"BK significantly suppressed the ongoing production of both Irf7 and Isg15 genes in B6 GM-cDCs."

29456540

Bradykinin affects IFNB1

| 1

Bradykinin inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"We found that BK strongly suppressed the induction of Ifn-beta (p < 0.05; Figure XREF_FIG C) indicating that BK is a negative regulator of the IFN response in immune cells in general, and in cDCs in particular, in vitro and in vivo."

29456540

Bosutinib affects MAP3K7

1 |

Bosutinib inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Bosutinib affects IKBKE

1 |

Bosutinib inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Bosutinib affects EIF2AK1

1 |

Bosutinib inhibits EIF2AK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Bithionol affects MAPK14

1 |

Bithionol inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

Bisphenol affects TICAM1

| 1

Bisphenol inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"However, TLR expression was significantly down-regulated in F1 larvae without bisphenol exposure but with bacterial and virus mimic treatment, indicating that parental exposure to bisphenol inhibited PAMPs recognition in F1 larvae.Innate immune signaling molecules downstream of TLRs are conserved in zebrafish and include orthologous MyD88, TRIF and other signaling molecules."

28806546

Bisphenol affects MYD88

| 1

Bisphenol inhibits MYD88. 1 / 1

| 1

---

➶

reach

"However, TLR expression was significantly down-regulated in F1 larvae without bisphenol exposure but with bacterial and virus mimic treatment, indicating that parental exposure to bisphenol inhibited PAMPs recognition in F1 larvae.Innate immune signaling molecules downstream of TLRs are conserved in zebrafish and include orthologous MyD88, TRIF and other signaling molecules."

28806546

Bisphenol A affects PYCARD

| 1

Bisphenol A inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Here we have shown for the first time that BPA inhibits lipid accumulation in hASC adipocytes by approx 70%, at least in part by suppressing LPL gene transcription during adipogenesis."

22662114

Bis(maltolato)oxovanadium(IV) affects JUN

1 |

Bis(maltolato)oxovanadium(IV) inhibits JUN. 1 / 1

1 |

---

➶

ctd

No evidence text available

17696279

Bis(maltolato)oxovanadium(IV) affects FOS

1 |

Bis(maltolato)oxovanadium(IV) inhibits FOS. 1 / 1

1 |

---

➶

ctd

No evidence text available

17696279

Bis(2-ethylhexyl) phthalate affects MAPK8

| 1

Bis(2-ethylhexyl) phthalate inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"sma-1 and jnk-1 was downregulated only by 10 muM of DEHP while isp-1 was downregulated by 10 muM of both DEHP and DEP."

29020644

Biphenylene affects IFNB1

| 1

Biphenylene inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Addition of the antioxidant diphenylene iodonium (DPI) diminished DMXAA induced IFN-beta, but this decrease was independent of both the NADPH oxidase, Nox2, and de novo generation of reactive oxygen species."

23027866

Biochanin A affects JUN

| 1

Biochanin A inhibits JUN. 1 / 1

| 1

---

➶

reach

"In this study I found that biochanin, a methoxy form of genistein, inhibits IL-8-mediated activation of nuclear transcription factor kappaB (NF-kappaB) and activator protein 1 (AP-1) more potently than genistein as shown in Jurkat T-cell line."

22387535

Bimatoprost affects NFKBIA

| 1

Bimatoprost inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"In this study, both latanoprost and bimatoprost were found to increase NF-kB and decrease IkappaBalpha."

27011234

Bilobalide affects RELA

| 1

Bilobalide inhibits RELA. 1 / 1

| 1

---

➶

reach

"Furthermore, ginkgolide and bilobalide also downregulated p-TAK1, p-IkBalpha, and p-IKKbeta and inhibited the OGD/R induced transfer of NF-kappaB p65 from cytoplasm to nucleus in BV2 microglia cells."

27562518

Bilobalide affects NFKBIA

| 1

Bilobalide inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Furthermore, ginkgolide and bilobalide also downregulated p-TAK1, p-IkBalpha, and p-IKKbeta and inhibited the OGD/R induced transfer of NF-kappaB p65 from cytoplasm to nucleus in BV2 microglia cells."

27562518

Bilobalide affects MAP3K7

| 1

Bilobalide inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"Furthermore, ginkgolide and bilobalide also downregulated p-TAK1, p-IkBalpha, and p-IKKbeta and inhibited the OGD/R induced transfer of NF-kappaB p65 from cytoplasm to nucleus in BV2 microglia cells."

27562518

Bilobalide affects IKBKB

| 1

Bilobalide inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Furthermore, ginkgolide and bilobalide also downregulated p-TAK1, p-IkBalpha, and p-IKKbeta and inhibited the OGD/R induced transfer of NF-kappaB p65 from cytoplasm to nucleus in BV2 microglia cells."

27562518

Bilirubin IXalpha affects NLRP3

| 1

Bilirubin IXalpha inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In vitro, bilirubin inhibited caspase-1 maturation and IL-1beta secretion in NLRP3, AIM2, and NLRC4 inflammasomes."

32325405

Bilirubin IXalpha affects CASP1

| 1

Bilirubin IXalpha inhibits CASP1. 1 / 1

| 1

---

➶

reach

"In vitro, bilirubin inhibited caspase-1 maturation and IL-1beta secretion in NLRP3, AIM2, and NLRC4 inflammasomes."

32325405

Betulinic acid affects NFKBIA

| 1

Betulinic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

medscan

"Betulinic acid also inhibited TNFalpha-induced activation of NF-kappaB via the IkappaBalpha pathway, thereby sensitizing the cells to TNFalpha-induced apoptosis."

18444250

Beta-maltose affects PYCARD

| 1

Beta-maltose inhibits PYCARD. 1 / 1

| 1

---

➶

medscan

"To test the effect of VHHASC on the quaternary structure of full-length ASC, we formed a complex of VHHASC and recombinantly expressed full-length ASC fused to maltose-binding protein, in which maltose-binding protein prevents ASC oligomerization."

27069117

Beta-eudesmol affects CASP1

| 1

Beta-eudesmol inhibits CASP1. 1 / 1

| 1

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➶

reach

"In addition, beta-eudesmol suppressed the activation of caspase-1 and expression of receptor interacting protein-2."

20604677

Beta-carotene affects NLRP3

| 1

Beta-carotene inhibits NLRP3. 1 / 1

| 1

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➶

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"Beta-Carotene (provitamin A) suppressed the NLRP3 inflammasome activation induced by various activators including MSU crystals, in mouse bone marrow derived primary macrophages (p < 0.05)."

32134203

Beta-carotene affects JUN

| 1

Beta-carotene inhibits JUN. 1 / 1

| 1

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➶

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"Beta-Carotene Inhibits Activation of NF-kappaB, Activator Protein-1, and STAT3 and Regulates Abnormal Expression of Some Adipokines in 3T3-L1 Adipocytes."

29629347

Beta-carotene affects FOS

| 1

Beta-carotene inhibits FOS. 1 / 1

| 1

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"Beta-Carotene suppressed the upregulation of NFATc1 and c-Fos by RANKL."

28263804

Beta-D-glucose affects STAT1

| 1

Beta-D-glucose inhibits STAT1. 1 / 1

| 1

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➶

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"In addition, zymosan, which activates hemi-TAM signaling by ligating Dectin-1, suppressed IFN-alpha-induced STAT1 activation (XREF_FIG)."

22368279

Beta-D-glucose affects RELA

| 1

Beta-D-glucose inhibits RELA. 1 / 1

| 1

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➶

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"Zymosan induced NF-kappaB p65 and p50 DNA binding were reduced significantly after HAP-lipo and NBD (NBD at 0.05 mg/mL) treatment for 4hours."

29383874

Beta-D-glucose affects PYCARD

| 1

Beta-D-glucose inhibits PYCARD. 1 / 1

| 1

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"The results showed that zymosan A significantly reduced the content of ASC in the brain of the mice in all the experimental groups, in the spleen in all the experimental groups except of group I (after 3 h since injection of zymosan A at 1 mg/kg b.w.), in the liver only in experimental groups IV, V and VI (after the injection of zymosan A at 100 mg/kg b.w.), while in the kidneys the effects were observed for groups III, V and VI."

22242950

Beta-D-fructofuranose affects NLRP3

| 1

Beta-D-fructofuranose inhibits NLRP3. 1 / 1

| 1

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➶

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"The restoration of fructose induced hyperuricemia and dyslipidemia by the treatment of allopurinol, quercetin and rutin blocked the NLRP3 inflammasome activation to improve the signaling impairments and reduce lipid accumulation in the kidney of rats."

22426011

Berberine affects RELA

| 1

Berberine inhibits RELA. 1 / 1

| 1

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➶

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"TNF-alpha-induced nuclear NF-kappaB p65 accumulation (XREF_FIG) was significantly suppressed by HMC05 and berberine (XREF_FIG)."

19736220

Berberine affects CASP1

| 1

Berberine inhibits CASP1. 1 / 1

| 1

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"The results from the tumor tissues were in accordance with the results from Saos-2 and MG-63 osteosarcoma cells (XREF_FIG), which illustrate that berberine attenuates the activation of caspase-1 and IL-1beta signal pathway."

28000894

Benzyl isothiocyanate affects NLRP3

| 1

Benzyl isothiocyanate inhibits NLRP3. 1 / 1

| 1

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➶

reach

"LPS/CC induced NLRP3 inflammasome activation and IL-1beta production were dose-dependently attenuated by BITC."

32126212

Benzoic acid affects IKBKB

| 1

Benzoic acid inhibits IKBKB. 1 / 1

| 1

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➶

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"The benzoic acid derivative 1 is able to inhibit IKKbeta activity in both cell-free and system with micromolar potency."

23294515

Benzo[a]pyrene affects IFNB1

| 1

Benzo[a]pyrene inhibits IFNB1. 1 / 1

| 1

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"Bp can suppress the production of IFNgamma and IFNbeta by infected macrophages, which subsequently leads to inadequate iNOS expression XREF_BIBR - XREF_BIBR."

25144195

Benzene affects RELA

1 |

Benzene inhibits RELA. 1 / 1

1 |

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➶

ctd

No evidence text available

15894107

Benzene affects NFKB1

1 |

Benzene inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

15894107

Benzene affects CASP1

| 1

Benzene inhibits CASP1. 1 / 1

| 1

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➶

reach

"p-Benzoquinone, a reactive metabolite of benzene, prevents the processing of pre-interleukins-1 alpha and -1 beta to active cytokines by inhibition of the processing enzymes, calpain, and interleukin-1 beta converting enzyme."

9118901

Benfotiamine affects RELA

| 1

Benfotiamine inhibits RELA. 1 / 1

| 1

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➶

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"Our data demonstrated that benfotiamine reduced the LPS stimulated intranuclear accumulation of NF-kappaB and p65 and decreased a fraction of cells with activated NF-kappaB signaling cascade."

25695433

Barium(2+) affects NLRP3

| 1

Barium(2+) inhibits NLRP3. 1 / 1

| 1

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➶

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"We previously showed that BA significantly inhibited the activation of NF-kappaB and the NLRP3 inflammasome during H. parasuis infection in piglet primary mononuclear phagocyte 34."

29339754

Barium(2+) affects JUN

| 1

Barium(2+) inhibits JUN. 1 / 1

| 1

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➶

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"The reporter assay and the inhibitor study of IL-1 beta transcription suggested that BA inhibited nuclear factor- kappa B and activator protein-1 by regulating I kappa B kinase, extracellular signal regulated kinase and P38, resulting in the down-regulation of IL-1 beta expression."

32140392

Barium(2+) affects ITCH

| 1

Barium(2+) inhibits ITCH. 1 / 1

| 1

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"10 BAs may cause cholestatic pruritus because BA levels are increased in the circulation 11 and skin 12 of patients with cholestasis, BA chelators relieve cholestatic pruritus, 13 and application of BAs to the skin causes itch."

25194674

Barium(2+) affects FOS

| 1

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| 1

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"Therefore, these data indicate that BA and the antioxidant NAC effectively inhibited H 2 O 2 -induced activation of PKC, ERK and c-Fos."

26542288

Barium atom affects TLR7

| 1

Barium atom inhibits TLR7. 1 / 1

| 1

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"The present study showed that xinjiaxiangruyin, yinqiaosan, and Gui Zhi Ma Huang Ge Ban Tang could lower the ratio of Th1 and Th2 cells and Th17 and Treg cells in normal and cold environments, as well as in TLR7 -/- mice, but Gui Zhi Ma Huang Ge Ban Tang is better."

29849712

Baicalin affects STAT1

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Baicalin inhibits STAT1. 1 / 1

| 1

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➶

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"Furthermore, baicalin inhibited STAT1 and activated STAT3 signaling pathways."

31802384

Baicalin affects NFKBIA

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Baicalin inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Baicalin also significantly down-regulated p-MAPK, p-Akt, p-p50, p-p65, and p-IkappaBalpha in IL-1beta-stimulated nasal fibroblasts."

28002421

Baicalein affects STAT1

| 1

Baicalein inhibits STAT1. 1 / 1

| 1

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➶

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"We found that the sham treatment (anti-CD3/-CD28 stimulation) increased the population of phosphorylated STATs, and that baicalein suppressed the activation of STAT-1 (a Th1 related signal), STAT-6 (a Th2 related signal), and STAT-3 (a Th17 related signal) (XREF_FIG)."

27561877

Baicalein affects NFKBIA

| 1

Baicalein inhibits NFKBIA. 1 / 1

| 1

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"Liu et al. investigated the therapeutic effects of baicalein in four myeloma cell lines, namely U266, NOP2, AMO1, and ILKM2, and demonstrated that baicalein suppresses proliferation and induces apoptosis of myeloma cells by blocking IkB-alpha degradation, resulting in down-regulation of IL-6 and XIAP gene expression [XREF_BIBR]."

25128647

Baicalein affects MAPK8

1 |

Baicalein inhibits MAPK8. 1 / 1

1 |

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➶

ctd

No evidence text available

10718847

Baicalein affects MAPK14

| 1

Baicalein inhibits MAPK14. 1 / 1

| 1

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➶

medscan

"Furthermore, two dissimilar 12-LO inhibitors, CDC and baicalein, blocked Angiotensin II-induced p38 mitogen-activated protein kinase activation."

12450322

Baicalein affects FOS

| 1

Baicalein inhibits FOS. 1 / 1

| 1

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"Interestingly, baicalein inhibited RANKL induced activation of signaling molecules (Akt, ERK and MAP kinase and NF-kappaB) and mRNA expression of osteoclast associated genes (TRAP, matrix metalloproteinase 9 and c-Src) and another transcription factors (c-Fos, Fra-2 and NFATc1)."

18786594

Baicalein affects CASP1

| 1

Baicalein inhibits CASP1. 1 / 1

| 1

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➶

reach

"Baicalein also inhibited NLRP3 and caspase-1 activation and suppressed gasdermin D (GSDMD)-dependent pyroptosis."

32761175

Bafilomycin A1 affects IFNB1

| 1

Bafilomycin A1 inhibits IFNB1. 1 / 1

| 1

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reach

"Bafilomycin A1 blocked IFN-beta production by S. pyogenes infected BMDMs (XREF_FIG), suggesting that hydrolytic degradation of the pathogen was a critical event in IFN-beta induction."

21625574

Azithromycin affects STAT1

| 1

Azithromycin inhibits STAT1. 1 / 1

| 1

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"Azithromycin polarizes macrophages towards an anti-inflammatory M2 phenotype, and inhibits pro-inflammatory STAT1 and NFκB signaling pathways [139, 140] ."

32353634

Azithromycin affects RELA

| 1

Azithromycin inhibits RELA. 1 / 1

| 1

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"Azithromycin also decreased p65 activation when compared to positive controls, but there was no statistically significant difference in the results for protein levels."

19716898

Azithromycin affects JUN

| 1

Azithromycin inhibits JUN. 1 / 1

| 1

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"Conversely, it has been shown that azithromycin inhibits the binding of activator protein-1, nuclear factor of activated T cells, and interferon consensus sequence binding protein to the DNA binding site in the IL-12p40 promoter, and down regulation of TLR-4 receptor by azithromycin has also been reported, and these could represent important mechanisms contributing to the anti-inflammatory effects of azithromycin."

25505605

Azanide affects RELA

| 1

Azanide inhibits RELA. 1 / 1

| 1

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"The observed increase in amide proton exchange raises the intriguing possibility that the mutant Arg could decrease p65 stability in a region that passes near the NLS polypeptide in the structure of the folded protein."

12460563

Azadirachtin A affects TRAF6

| 1

Azadirachtin A inhibits TRAF6. 1 / 1

| 1

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"Azadirachtin inhibited TRAF6 mediated, but not TRAF2 mediated NF-kappaB activation."

21127062

Auraptene affects NFKBIA

| 1

Auraptene inhibits NFKBIA. 1 / 1

| 1

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➶

eidos

"The existence of NF-kappaB ( p65 ) in platelets was observed by confocal microscopy , and auraptene attenuated NF-kappaB activation such as IkappaBalpha and p65 phosphorylation and reversed IkappaBalpha degradation in collagen-activated platelets ."

32646046

Auranofin affects TICAM1

| 1

Auranofin inhibits TICAM1. 1 / 1

| 1

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"For example, auranofin, an organogold compound, has also been shown to inhibit TLR4 dimerization and TLR3 dependent TRIF signalling [XREF_BIBR]."

25975607

Auranofin affects TBK1

| 1

Auranofin inhibits TBK1. 1 / 1

| 1

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"Furthermore, auranofin inhibited TBK1 kinase activity in vitro."

20607500

Atorvastatin affects TICAM1

| 1

Atorvastatin inhibits TICAM1. 1 / 1

| 1

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"Atorvastatin decreased the neural injury and the elevation of TLR4, MyD88, TRIF, pro inflammatory cytokines and oxidative stress caused by CIH."

26200444

Atorvastatin affects NFKBIA

| 1

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| 1

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"As expected, OGD induced BV2 microglia exhibited significantly increased expression of inflammatory cytokines, such as TNF-alpha and COX2, as well as enhanced activation of pIkappaBalpha and pNF-kappaB, which could be significantly decreased by rosuvastatin and atorvastatin treatment."

30911291

Atorvastatin affects NFKB1

| 1

Atorvastatin inhibits NFKB1. 1 / 1

| 1

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"Although serum MCP-1 and MIF concentrations were not changed by either statins, atorvastatin administration increased PPAR-alpha and -gamma mRNA abundances and decreased NF-kappaB p50, p65, MCP-1 and TNF-alpha mRNA abundances in atherosclerotic lesions."

21481872

Atorvastatin affects IFNB1

| 1

Atorvastatin inhibits IFNB1. 1 / 1

| 1

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"Atorvastatin dose dependently inhibits interferon-beta induction of P-Y-STAT1 and downstream proteins."

22801747

Atorvastatin affects FOS

| 1

Atorvastatin inhibits FOS. 1 / 1

| 1

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"The densitometric value of reverse transcription (RT)-PCR normalized by the GAPDH intensity showed that atorvastatin significantly decreased the RANKL mediated or IL-1beta-stimulated expression of c-Fos and NFATc1 mRNA (XREF_FIG)."

28352062

Astaxanthin affects JAK1

| 1

Astaxanthin inhibits JAK1. 1 / 1

| 1

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"Astaxanthin mediates the inhibition of the Janus kinase 1 (JAK1)/STAT3 (signal transducer and activator of transcription 3) signaling pathway in hepatocellular carcinoma CBRH-7919 cells which down-regulates the anti-apoptotic gene expression of Bcl-2 and Bcl-xl, while also enhancing the pro apoptotic gene expression of Bax resulting in apoptosis [XREF_BIBR]."

26378548

Astaxanthin affects IKBKB

| 1

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| 1

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"We found that astaxanthin inhibits NF-kappaB and Wnt signaling by downregulating the key regulatory enzymes IKKbeta and GSK-3beta."

23726989

Astaxanthin affects CASP1

| 1

Astaxanthin inhibits CASP1. 1 / 1

| 1

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"Infiltration of inflammatory cells in the lung, production of mucus, lung fibrosis, and expression of caspase-1 or caspase-3 were suppressed in OVA induced asthmatic animal treated with astaxanthin."

29160801

Astatine atom affects RELA

| 1

Astatine atom inhibits RELA. 1 / 1

| 1

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"These results demonstrate that the AT extract blocks TNF-alpha-induced signaling of NF-kappaB p65 in vascular endothelial cells."

29302580

Astatine atom affects JUN

| 1

Astatine atom inhibits JUN. 1 / 1

| 1

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"However, while in this study, in AT 2 -transfected rat adult vascular smooth muscle cells, decreased c- fos expression was observed as a result of AT 2 receptor stimulation, studies in PC12W cells did not reveal an inhibitory effect of the AT 2 receptor on EGF induced stimulation of c- fos and c- Jun [43]."

11384780

Asiatic acid affects NLRP3

| 1

Asiatic acid inhibits NLRP3. 1 / 1

| 1

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"These data demonstrate that Asiatic acid both inhibits the activation of the NLRP3 inflammasome by downregulating mitochondrial reactive oxygen species directly to protect dopaminergic neurons from, and improves mitochondrial dysfunction in SH-SY5Y cells, which were established as a model of Parkinson 's disease."

30971058

Ascr#1 affects NFKBIA

| 1

Ascr#1 inhibits NFKBIA. 1 / 1

| 1

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➶

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"Decreased TNF-alpha-induced IkappaBalpha phosphorylation in HepG2 cells treated with daumone."

25954133

Ascorbic acid affects NLRP3

| 1

Ascorbic acid inhibits NLRP3. 1 / 1

| 1

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"•Vitamin C: Like flavonoids, ascorbic acid inhibits NLRP3 inflammasome activation.22 Clinical trials have found that vitamin C shortens the frequency, duration and severity of the common cold and the incidence of pneumonia.23 Typical daily dosing of vitamin C ranges from 500 mg to 3000 mg daily with even higher doses utilized during times of acute infection."

32229082

Artesunate affects TRAF6

| 1

Artesunate inhibits TRAF6. 1 / 1

| 1

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➶

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"The study also found that artesunate blocked TRAF6–Beclin 1–PI3KC3 signaling and Beclin 1–PI3KC3 interactions."

30744138

Arsenic(3+) affects PYCARD

| 1

Arsenic(3+) inhibits PYCARD. 1 / 1

| 1

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"40, No. 2, 1970 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Table I. BASIC A14INO ACIDS AND OTHER CATIONS AS INHIBITORS OF SYSTE14 ASC IN THE PIGEON RED BLOOD CELL."

5474782

Arsenic atom affects RELA

| 1

Arsenic atom inhibits RELA. 1 / 1

| 1

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"Interestingly, under the condition of mild p53 activation, low-dose arsenic induced p65 nuclear distribution was completely blocked (XREF_FIG, As versus Nutlin 3a+ As), suggesting that p53 inhibition is necessary to allow NF-kappaB activation."

23524579

Arsenic atom affects MAPK8

1 |

Arsenic atom inhibits MAPK8. 1 / 1

1 |

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➶

ctd

No evidence text available

11756236

Arsenic atom affects IFNB1

| 1

Arsenic atom inhibits IFNB1. 1 / 1

| 1

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"Our data suggest an important role of the arsenic induced suppression of IFN-beta on the disturbances in immunological defense against both bacteria and viruses."

30726814

Arachidonic acid affects NFKBIA

| 1

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| 1

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"Sung et al. showed that AA inhibits both inducible and constitutive NF-kappaB activation, and suppresses activation of IkappaBalpha kinase which leads to abrogation of its phosphorylation and eventual degradation in multiple cancer cells (myeloid and T-cell lymphoma cells, human embryonic cells, lung, prostate and esophageal cancer cells)."

20599773

Arachidonic acid affects MAPK14

| 1

Arachidonic acid inhibits MAPK14. 1 / 1

| 1

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➶

medscan

"Specificity of arachidonic acid-induced inhibition of growth and activation of c-jun kinases and p38 mitogen-activated protein kinase in hematopoietic cells."

12051955

Arachidonic acid affects JUN

| 1

Arachidonic acid inhibits JUN. 1 / 1

| 1

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"In contrast, AA (25 micromol/L) attenuated the oxalate induced increase in c-jun and egr-1 mRNA, presumably by inhibiting PLA2 activity."

10916087

Arachidonic acid affects FOS

| 1

Arachidonic acid inhibits FOS. 1 / 1

| 1

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"Blocking the conversion of arachidonic acid to prostaglandins by inhibiting cyclooxygenase abolishes arachidonic acid induced accumulation of c-fos and Egr-1 mRNA."

7961634

Aptamer affects NFKB1

| 1

Aptamer bound to NCL inhibits NFKB1. 1 / 1

| 1

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"Molecular studies have shown that this aptamer binds to the cell surface protein nucleolin and inhibits the activity of NF-KB, a ubiquitous transcription factor, through intracellular complex formation [108]."

20657381

Aprepitant affects ITCH

| 1

Aprepitant inhibits ITCH. 1 / 1

| 1

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➶

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"2 For patients who were refractory to standard treatment for pruritis, short-course aprepitant reduced median itch on the Visual Analogue Scale (VAS) from 8.00 (95% CI 7.93-8.57) at baseline to 1.00 (0.00-2.00) after 1 week of treatment (p < 0.0001)."

22995652

Apramycin affects RELA

| 1

Apramycin inhibits RELA. 1 / 1

| 1

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"The relA and rsh genes were disrupted by the insertion of a hygromycin resistance gene and an apramycin resistance gene, respectively."

15133110

Apocynin affects RELA

| 1

Apocynin inhibits RELA. 1 / 1

| 1

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➶

medscan

"Salusin-β-induced ACAT-1 and VCAM-1 expressions, and p65-NFκB nuclear translocation in Vascular smooth muscle cells were prevented by the treatment with a ROS scavenger N-acetyl-cysteine , a NADPH oxidase inhibitor apocynin or knockdown of NOX2 with siRNA ( )."

27004848

Apocynin affects NFKBIA

| 1

Apocynin inhibits NFKBIA. 1 / 1

| 1

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➶

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"In addition, apocynin moderately attenuated the activation of IkappaBalpha significantly induced by RANKL (P <.001)."

29957360

Apocynin affects JUN

| 1

Apocynin inhibits JUN. 1 / 1

| 1

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➶

medscan

"Furthermore, CSE-induced p300 and c-Jun complex formation was inhibited by pretreatment with diphenyleneiodonium chloride, apocynin, N-acetyl-L-cysteine or SP600125."

21268080

Apocynin affects CASP1

| 1

Apocynin inhibits CASP1. 1 / 1

| 1

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➶

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"In support of this, caspase-1 activation by hyperosmotic stress was inhibited by the mitochondrial ROS inhibitor MitoTEMPO, but not by the NADPH oxidase inhibitor apocynin or the xanthine oxidase inhibitor allopurinol (XREF_FIG)."

25959047

Apigenin affects RIPK1

| 1

Apigenin inhibits RIPK1. 1 / 1

| 1

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➶

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"The results showed that apigenin induced a dose dependent degradation of RIP1, Raf-1, Src and Cdk4 kinases."

21871133

Apigenin affects PYCARD

| 1

Apigenin inhibits PYCARD. 1 / 1

| 1

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➶

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"These results suggest that apigenin inhibits the oligomerization of ASC and thus, interferes with the assembly of a functional inflammasome."

25192391

Apigenin affects NFKB1

| 1

Apigenin inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Furthermore, we have shown that apigenin suppresses NF-KB activation."

24614817

Apigenin affects MYD88

| 1

Apigenin inhibits MYD88. 1 / 1

| 1

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➶

eidos

"Apigenin in LPS-exposed macrophages reduces TLR-4 , MyD88 and phosphorylation of IkappaKB levels through nuclear NF-kappaB p65 signaling pathway [ 192 ] ."

32326376

Apigenin affects IFNAR1

| 1

Apigenin inhibits IFNAR1. 1 / 1

| 1

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➶

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"This result indicated that apigenin suppressed IFNAR1 degradation by inhibition of the 26S proteasome, similar to a previous finding that MG132 and lysosomal inhibitors promoted IFNAR1 accumulation."

27356910

Apigenin affects FOS

| 1

Apigenin inhibits FOS. 1 / 1

| 1

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➶

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"Previous study showed that treatment of apigenin inhibited c-Fos / AP-1 activity by regulating and Janus kinase 2 (JAK2) / signal transducer and activator of transcription 1/2 (STAT1/2) pathways in interleukin-1beta-treated articular chondrocytes [XREF_BIBR]."

22583402

Apigenin affects CASP1

| 1

Apigenin inhibits CASP1. 1 / 1

| 1

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➶

reach

"The results of Western blot indicated that apigenin inhibited the maturation of pro-IL-1beta and pro-caspase-1."

22321793

Antioxidant affects NLRP3

| 1

Antioxidant inhibits NLRP3. 1 / 1

| 1

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➶

eidos

"In the same study it was demonstrated that MB downregulates ROS , NFB , and NLRP3 by the antioxidant effect which reduces NFkB and NLRP3 proteins expression by ROS / NF-KB-NLRP3 pathway ."

32326607

Antioxidant affects NFKB1

| 1

Antioxidant inhibits NFKB1. 1 / 1

| 1

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➶

sparser

"Increasing amounts of catalytic antioxidants (25, 50, 100, and 200 μM) were efficient in decreasing p50 DNA binding in a concentration-dependent manner as depicted in Fig. 5A . Catalytic antioxidants directly inhibited p50 DNA binding by an oxidation mechanism because the addition of the reducing agent, DTT, at 100 and 50 mM final concentration was able to restore p50 DNA binding to a consensus NF-κB oligo after treatment with 200 μM catalytic antioxidant but not 10 or 1 mM DTT (Fig. 5A) ."

14744635

Antimony(3+) affects MAPK8

| 1

Antimony(3+) inhibits MAPK8. 1 / 1

| 1

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➶

reach

"SB, but not SP, was very effective in lowering the activation of p38 MAPK produced by AA plus 3-MA to below basal levels (XREF_FIG B and C; lanes 3 and 4) while SP, but not SB, effectively blocked the 2-3 fold elevated ratio of pJNK1 and JNK1 to below basal levels (XREF_FIG D and E : lanes 3 and 5), validating their specific inhibitory effectiveness."

24273738

Anthraquinone affects NLRP3

| 1

Anthraquinone inhibits NLRP3. 1 / 1

| 1

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➶

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"In a third study, Rhein, a traditional Chinese medicine (lipophilic anthraquinone) found in medicinal herbs that has antiviral activities, inhibited RSV-induced activation of the NLRP3 inflammasome and production of lung IL-33 in mice [115]."

32397226

Anthralin affects CASP1

1 |

Anthralin inhibits CASP1. 1 / 1

1 |

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➶

ctd

No evidence text available

23611293

Anthra[2,3-b]benzo[d]thiophene affects CASP1

| 1

Anthra[2,3-b]benzo[d]thiophene inhibits CASP1. 1 / 1

| 1

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➶

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"In addition, ABT significantly reduced caspase-1 activity in skin lesions of AD mice."

29957081

Anthra[1,9-cd]pyrazol-6(2H)-one affects STAT1

| 1

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits STAT1. 1 / 1

| 1

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reach

"As shown in XREF_FIG, SP600125, a JNK inhibitor, suppressed poly (I : C)-induced STAT1 activation in a dose dependent manner, indicating the involvement of JNK MAPK in poly (I : C)-induced STAT1 activation."

28027722

Anthra[1,9-cd]pyrazol-6(2H)-one affects RIPK1

| 1

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits RIPK1. 1 / 1

| 1

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➶

reach

"RIP-1 upregulation was inhibited by SP600125 indicating that it is JNK1 dependent."

25581256

Anthra[1,9-cd]pyrazol-6(2H)-one affects PYCARD

| 1

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits PYCARD. 1 / 1

| 1

---

➶

medscan

"Induction of TMS1/ASC by TNFalpha was blocked by co-expression of a dominant negative IkappaBalpha, small interfering RNA-mediated knockdown of RelA/p65, or concurrent treatment with SP600125, indicating a requirement for the nuclear factor-kappaB and jun kinase signaling pathways."

16715133

Anthra[1,9-cd]pyrazol-6(2H)-one affects MAPK14

| 1

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Before insulin was added in, macrophages were preincubated with the inhibitors of the insulin signaling pathway, including wortmannin, phosphatidylinositol 3-kinase inhibitor; PD98059, extracellular signal-regulated kinase (ERK) inhibitor; SB203580, p38 mitogen-activated protein kinase (p38MAPK) inhibitor; SP600125, c-Jun N-terminal kinase (JNK) inhibitor and U73122, phospholipase C-gamma (PLC-gamma) inhibitor. 1999999={EffectorType="inhibitor" Target=12811969}}"

19269342

Anthra[1,9-cd]pyrazol-6(2H)-one affects IRF7

| 1

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits IRF7. 1 / 1

| 1

---

➶

medscan

"Furthermore, SP600125 and dexamethasone inhibited LPS-induced IFN regulatory factor-7 activity."

16237059

Anthra[1,9-cd]pyrazol-6(2H)-one affects CASP1

| 1

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits CASP1. 1 / 1

| 1

---

➶

reach

"As for the phosphorylation pathway, PD98059 (ERK1/2 inhibitor), SB203580 (p38 MAPK inhibitor), SP600125 (JNK1/2 inhibitor) decreased caspase-1 activity and interleukin-1beta production to approximately 50% of the controls."

22247602

Antagonist affects TRIM25

| 1

Antagonist inhibits TRIM25. 1 / 1

| 1

---

➶

eidos

"Given the important role of TRIM25 in RIG-I-mediated antiviral gene induction , several viral pathogens have evolved antagonists that directly inhibit TRIM25 activity , including NS1 from IAV96 ,98 , NS1 from respiratory syncytial virus99 , E6 from human papilloma virus97and the BPLF1 protein from Epstein-Barr virus100 , or the subgenomic RNA of dengue virus101 ( reviewed in detail elsewhere102 ,103 ) ."

31792373

Antagonist affects NFKBIA

| 1

Antagonist inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Therefore, these data suggest that ACE2/Ang-(1-7)/Mas may have a protective effect on LPSinduced apoptosis and inflammation in PMVECs, mainly through inhibition of the JNK pathway.In the present study, we found that ACE2 overexpression significantly inhibited LPS-induced activation of the NF-kB and degradation of IkBa protein, which was strikingly reversed by the Mas receptor antagonist."

25644821

Antagonist affects JAK1

| 1

Antagonist inhibits JAK1. 1 / 1

| 1

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➶

reach

"MARV matrix protein VP40 is also a known IFN antagonist, blocking the JAK1 activation of downstream IFN signaling [14,16], and a putative MARV GP immunomodulatory domain has yet-unknown effects in ERBs [38]."

30400182

Antagonist affects CASP1

| 1

Antagonist inhibits CASP1. 1 / 1

| 1

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➶

sparser

"Compstatin was particularly effective in reducing caspase-1 activity, however, also eculizumab and the C5aR antagonist significantly (p < 0.05) inhibited caspase-1 in monocytes suggesting that C5a is a mediator also for CC-induced caspase-1 activation."

24554772

Angiotensin affects NLRP3

| 1

Angiotensin inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Investigations also demonstrated that angiotensin [[1], [2], [3], [4], [5], [6], [7]] down-regulates NLRP3 inflammasome, via inhibition of angiotensin II and NADPH oxidase (NOX)-dependent oxidative stress, and consequently decreased rates of liver fibrosis [74,75]."

30831142

Andrographolide affects JUN

1 |

Andrographolide inhibits JUN. 1 / 1

1 |

---

➶

ctd

No evidence text available

19426720

Andrographolide affects FOS

1 |

Andrographolide inhibits FOS. 1 / 1

1 |

---

➶

ctd

No evidence text available

19426720

Anacardic acid affects MAP3K7

1 |

Anacardic acid inhibits MAP3K7. 1 / 1

1 |

---

➶

ctd

No evidence text available

18349320

Ammonium chloride affects NFKB1

| 1

Ammonium chloride inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Indeed, monensin and ammonium chloride blocked the activation of A-SMase and NF-KB."

7923351

Amlodipine affects MAPK14

| 1

Amlodipine inhibits MAPK14. 1 / 1

| 1

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➶

reach

"In the EXPLOR Study, the combination of amlodipine and valsartan lowered CSBP to a larger extent than amlodipine and atenolol in combination [XREF_BIBR]."

28127560

Amlexanox affects TICAM1

| 1

Amlexanox inhibits TICAM1. 1 / 1

| 1

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➶

reach

"In addition, we demonstrate that the IKKepsilon and TBK1 inhibitor Amlexanox decreases immune activation of TRIF dependent pathway in the brain and reduces ethanol consumption, suggesting the TRIF dependent pathway regulates drinking."

28840972

Amlexanox affects IRF3

| 1

Amlexanox inhibits IRF3. 1 / 1

| 1

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➶

reach

"In particular, pharmacological inhibition of IRF3 by Amlexanox inhibited the growth of tumor cells with YAP hyperactivation."

29339449

Amlexanox affects IFNB1

| 1

Amlexanox inhibits IFNB1. 1 / 1

| 1

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➶

reach

"Amlexanox inhibited also the release of IFN-beta by all MSC sources in response to Poly (I : C)/LyoVec demonstrating the involvement of TBK1 and IKK-epsilon and IRF7 in Poly (I : C)/LyoVec triggered IFN-beta production."

28588282

Amitriptyline affects NLRP3

| 1

Amitriptyline inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Antidepressant Amitriptyline Does Not Inhibit NLRP3 Dependent Caspase-1 Activation but Suppresses LPS Triggered IL-1beta mRNA Production."

29016824

Aminoguanidine affects TANK

| 1

Aminoguanidine inhibits TANK. 1 / 1

| 1

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reach

"EtOH WD increased anxiety like behavior in the novel tank test, an effect that was blocked by aminoguanidine."

32283112

Amino acid affects STAT1

| 1

Amino acid inhibits STAT1. 1 / 1

| 1

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reach

"Further analysis demonstrated that a single amino acid determinant, the Thr at aa 538 of nsP1 of Sindbis virus, restores the STAT1 inhibition of nsP1 when it is introduced into avirulent strains and is required for Sindbis virus virulence in vivo (220)."

29312301

Amino acid affects IFNB1

| 1

Amino acid inhibits IFNB1. 1 / 1

| 1

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➶

reach

"Amino acid Asp at position 185 modulates the capacity of nsp4 to inhibit 413 the activation of IFN-β."

| PMC

Amino acid affects IFIH1

| 1

Amino acid inhibits IFIH1. 1 / 1

| 1

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➶

reach

"Interestingly, a recent study shows that a single amino acid difference between RLRs determines the ability of paramyxovirus V proteins to suppress MDA5 versus RIG-I (Rodriguez and Horvath, 2013)."

25749629

Amino acid affects FOS

| 1

Amino acid inhibits FOS. 1 / 1

| 1

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reach

"The amino acid also inhibits angiotensin IIinduced activation of c-fos, upregulation of atrial natriuretic factor and induction of TGF-betal."

11547801

Amino acid affects EIF2AK1

| 1

Amino acid inhibits EIF2AK1. 1 / 1

| 1

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reach

"In mammalian cells there are at least four eIF2a kinases, including GCN2, PKR, PERK and HRI, which are activated by amino acid starvation, double stranded RNA, ER stress and haem depletion, respectively (Berlanga et al., 1999; Harding et al., 1999; Kaufman, 2000; Lu et al., 2001) ."

17490409

Amiloride affects PYCARD

| 1

Amiloride inhibits PYCARD. 1 / 1

| 1

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reach

"Interestingly, a similar type of substrate protection was seen in the amphibian cornea, in which both reduced glutathione and amiloride blocked ASC stimulated short circuit currents when added prior to ASC addition, but not when added after ASC (McGahan and Bentley, 1982)."

17258485

Alvocidib affects MYD88

| 1

Alvocidib inhibits MYD88. 1 / 1

| 1

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➶

reach

"Flavopiridol inhibited nitric oxide production induced by a MyD88 dependent TLR2 ligand, but not a MyD88 independent TLR3 ligand."

21204955

Alvocidib affects EIF2AK1

1 |

Alvocidib inhibits EIF2AK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

Alvespimycin affects TRAF3

| 1

Alvespimycin inhibits TRAF3. 1 / 1

| 1

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➶

reach

"17-DMAG inhibits HSP 90 and induces proteosome dependent degradation of CRAF-1, ERBB2 and inhibited phosphorylation of AKT (XREF_FIG, right panels)."

21495622

Alvespimycin affects JUN

| 1

Alvespimycin inhibits JUN. 1 / 1

| 1

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➶

reach

"In addition to these two enhancers, activator protein 1 activation by Tax 34 was also inhibited by 17-DMAG (data not shown)."

23955587

Alvespimycin affects CASP1

| 1

Alvespimycin inhibits CASP1. 1 / 1

| 1

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reach

"Administration of 17-DMAG in mouse model of ALD significantly downregulated NLRP3 inflammasome mediated caspase-1 (CASP-1) activity and cytokine secretion, with reduction in ALD."

32282939

Alverine affects TICAM1

| 1

Alverine inhibits TICAM1. 1 / 1

| 1

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➶

reach

"Alverine suppressed MyD88- and TRIF dependent NF-kappaB luciferase activity (XREF_FIG B, C, respectively), independent of the AP-1-mediated pathway (data not shown)."

32326535

Alverine affects MYD88

| 1

Alverine inhibits MYD88. 1 / 1

| 1

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➶

reach

"Alverine suppressed MyD88- and TRIF dependent NF-kappaB luciferase activity (XREF_FIG B, C, respectively), independent of the AP-1-mediated pathway (data not shown)."

32326535

Aluminium(3+) affects PYCARD

| 1

Aluminium(3+) inhibits PYCARD. 1 / 1

| 1

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➶

reach

"Our results showed that the Al induced decreases of both ASC/(ASC + DHA) and GSH/(GSH + GSSG) ratios were greater at 0.5 mM S than those at 1 mM S (XREF_FIG D, H, L, P)."

29207499

Aluminium(3+) affects NLRP3

| 1

Aluminium(3+) inhibits NLRP3. 1 / 1

| 1

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reach

"Alum und LLOMe, on the other hand, degraded inflammatory proteins (including caspase-1), inhibited NALP3 signaling and led to necrotic death [XREF_BIBR]."

26344620

Aluminium(3+) affects MYD88

| 1

Aluminium(3+) inhibits MYD88. 1 / 1

| 1

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reach

"The TLR independent adjuvant alum mainly induced Th2 type cytokines (as expected) in WT mice, and deletion of MyD88 in macrophages, in vivo, resulted in non significant decreases in the levels of the Th2 type cytokines except for IL-5, which was significantly decreased."

28316602

Aluminium(3+) affects MAPK14

| 1

Aluminium(3+) inhibits MAPK14. 1 / 1

| 1

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➶

sparser

"Two series of 1,2,4-triazole based benzothiazole derivatives 249 and 250 (Fig. 46) were synthesized and evaluated for their in vitro anti-inflammatory activity and p38α MAP kinase inhibition by Tariq et al [221,222]."

| PMC

Alpha-tocopherol affects JUN

| 1

Alpha-tocopherol inhibits JUN. 1 / 1

| 1

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➶

eidos

"Upregulation of pERK and c-JUN by gamma-tocotrienol and not alpha-tocopherol are essential to the differential effect on apoptosis in prostate cancer cells Background alpha-tocopherol ( AT ) and gamma-tocotrienol ( GT3 ) are vitamin E isoforms considered to have potential chemopreventive properties ."

32414345

Alpha-linolenic acid affects RELA

| 1

Alpha-linolenic acid inhibits RELA. 1 / 1

| 1

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➶

reach

"Alpha-linolenic acid based nano-suspension protect against lipopolysaccharides induced mastitis by inhibiting NFkappaBp65, HIF-1alpha, and mitochondria mediated apoptotic pathway in albino Wistar rats."

31207257

Alpha-NeupAc-(2->8)-alpha-NeupAc-(2->3)-beta-D-Galp affects NFKB1

| 1

Alpha-NeupAc-(2->8)-alpha-NeupAc-(2->3)-beta-D-Galp inhibits NFKB1. 1 / 1

| 1

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➶

reach

"DSG inhibits nuclear translo cation of transcription factor NF-KB (36), which could have an effect on cytokine pro duction (36)."

11045661

Alpha-L-Rhap-(1->3)-[alpha-L-Rhap-(1->3)-beta-D-Glcp-(1->4)]-alpha-D-Glcp-(1->2)-alpha-D-GlcpO[CH2]5NH2 affects TLR7

| 1

Alpha-L-Rhap-(1->3)-[alpha-L-Rhap-(1->3)-beta-D-Glcp-(1->4)]-alpha-D-Glcp-(1->2)-alpha-D-GlcpO[CH2]5NH2 inhibits TLR7. 1 / 1

| 1

---

➶

eidos

"of pseudouridine ( Psi ) , 5methylcytidine ( m5C ) , 2thio uridine ( s2U ) or N6methyladenosine ( m6A ) was found to potently inhibit TLR7 and TLR8 and to reduce TLR3 activity , which is the least sensitive receptor to RNA modifications 88 ."

27455396

Alpha-D-GalpNAc-(1->3)-[alpha-L-Fucp-(1->2)]-beta-D-Galp-(1->4)-beta-D-GlcpNAc affects NLRP3

| 1

Alpha-D-GalpNAc-(1->3)-[alpha-L-Fucp-(1->2)]-beta-D-Galp-(1->4)-beta-D-GlcpNAc inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Glyburide, a type 2 diabetes drug, has been shown to specifically inhibit the NLRP3 inflammasome in response to microbial and crystalline stimuli XREF_BIBR."

25254654

Aloin A affects RELA

| 1

Aloin A inhibits RELA. 1 / 1

| 1

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➶

reach

"Moreover, aloin inhibited hepatocyte apoptosis and inflammatory response that was caused by the upregulated expression of Bcl-2, the downregulated expression of cleaved caspase3 (C-caspase3), Bax, Toll like receptor 4 (TLR4), FADD, MyD88, TRAF6, phosphorylated IKK alpha / beta (p-IKK alpha / beta), and phosphorylated nuclear factor kappa B p65 (p-NF- kappa B p65)."

31827674

Aloin A affects NLRP3

| 1

Aloin A inhibits NLRP3. 1 / 1

| 1

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➶

reach

"We found that aloin significantly inhibited the activation of NF-kappaB and NLRP3 inflammasome in ALI induced by LPS."

32419528

All-trans-retinol affects JUN

| 1

All-trans-retinol inhibits JUN. 1 / 1

| 1

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➶

reach

"Vitamin A is known to suppress the activity of the transcription factors, nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), as do glucocorticoids."

15336952

All-trans-retinoic acid affects STAT1

| 1

All-trans-retinoic acid inhibits STAT1. 1 / 1

| 1

---

➶

medscan

"Interestingly, while the upregulation of STAT-1 by IFNgamma is partially inhibited by retinoic acid, IFNgamma is shown to repress retinoic acid-driven TGFbeta-2 induction, pointing to the involvement of alternative mechanism(s) in IFNgamma-retinoic acid synergism."

16007204

All-trans-retinoic acid affects NFKB1

| 1

All-trans-retinoic acid inhibits NFKB1. 1 / 1

| 1

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➶

reach

"ATRA also reduced nuclear levels of both subunits (p50 and p65) of NF-kappaB."

10432387

All-trans-retinoic acid affects MAPK8

| 1

All-trans-retinoic acid inhibits MAPK8. 1 / 1

| 1

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➶

reach

"Using specific PARP-1 inhibitors and siRNAs, we show that PARP-1 is essential for the synergistic apoptotic effect and c-Jun N-terminal kinase 1 (JNK1) activation triggered by the ATRA and TNFalpha combination."

18084321

All-trans-retinoic acid affects MAPK14

1 |

All-trans-retinoic acid inhibits MAPK14. 1 / 1

1 |

---

➶

ctd

No evidence text available

16424397

All-trans-retinoic acid affects DDX58

| 1

All-trans-retinoic acid inhibits DDX58. 1 / 1

| 1

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➶

reach

"By contrast, following the knockdown of ATRA induced RIG-I, the levels of phosphorylated AKT increased, AKT was activated, the level of phosphorylated FOXO3A was increased, and FOXO3A was deactivated."

28656276

All-cis-octadeca-6,9,12,15-tetraenoic acid affects CASP1

| 1

All-cis-octadeca-6,9,12,15-tetraenoic acid inhibits CASP1. 1 / 1

| 1

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➶

reach

"Stearidonic acid (SDA; 18:4 n-3) and docosahexaenoic acid (DHA; 22:6 n-3) inhibited inflammasome related molecule synthesis and cathepsin S and caspase-1 activation, which further reduced the preterm delivery rate of pregnant mice induced by lipopolysaccharide (92.9% vs 69.7% [DHA]; 92.9% vs 53.5% [SDA])."

30287519

All-cis-icosa-8,11,14-trienoic acid affects PYCARD

| 1

All-cis-icosa-8,11,14-trienoic acid inhibits PYCARD. 1 / 1

| 1

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➶

reach

"DGLA enriched medium suppressed both baseline and rIL-1 beta stimulated ASC growth fivefold, compared with medium supplemented with arachidonic acid."

2553025

All-cis-docosa-4,7,10,13,16,19-hexaenoic acid affects NLRP3

| 1

All-cis-docosa-4,7,10,13,16,19-hexaenoic acid inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Docosahexaenoic acid and eicosapentaenoic acid seem to diminish activation of the NLRP3 inflammasome via the G protein coupled receptor 120 (Gpr120) [XREF_BIBR, XREF_BIBR]."

26324406

All-cis-docosa-4,7,10,13,16,19-hexaenoic acid affects MAP3K7

| 1

All-cis-docosa-4,7,10,13,16,19-hexaenoic acid inhibits MAP3K7. 1 / 1

| 1

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➶

reach

"It is worthwhile to note that docosahexaenoic acid (DHA), a precursor of RvD1, was shown to inhibit TAK1 activation via a GPR120 dependent signaling pathway."

25320283

All-cis-docosa-4,7,10,13,16,19-hexaenoic acid affects CASP1

| 1

All-cis-docosa-4,7,10,13,16,19-hexaenoic acid inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Stearidonic acid (SDA; 18:4 n-3) and docosahexaenoic acid (DHA; 22:6 n-3) inhibited inflammasome related molecule synthesis and cathepsin S and caspase-1 activation, which further reduced the preterm delivery rate of pregnant mice induced by lipopolysaccharide (92.9% vs 69.7% [DHA]; 92.9% vs 53.5% [SDA])."

30287519

All-cis-5,8,11,14,17-icosapentaenoic acid affects NLRP3

| 1

All-cis-5,8,11,14,17-icosapentaenoic acid inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Docosahexaenoic acid and eicosapentaenoic acid seem to diminish activation of the NLRP3 inflammasome via the G protein coupled receptor 120 (Gpr120) [XREF_BIBR, XREF_BIBR]."

26324406

Alizarin affects CASP1

| 1

Alizarin inhibits CASP1. 1 / 1

| 1

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➶

reach

"Previous studies have shown that extracellular ATP requires the purinergic receptor P2X7R to induce inflammasome activation 26, and pre-treatment with the P2X7R antagonist AZ10606120 (AZ) indeed prevented pro-caspase-1 cleavage in response to LPS+ATP (XREF_FIG)."

25266676

Aldosterone affects TBK1

| 1

Aldosterone inhibits TBK1. 1 / 1

| 1

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➶

reach

"Corticosterone had a similar effect to aldosterone causing an increase in potassium excretion and a decrease in the Na/K ratio."

7439669

Agonist affects JUN

| 1

Agonist inhibits JUN. 1 / 1

| 1

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➶

reach

"For example, the PPARγ agonist inhibits NF-kB, activator protein-1- (AP-1-) mediated inflammatory responses in multiple tissues [10]."

32158560

Agonist affects IKBKB

| 1

Agonist inhibits IKBKB. 1 / 1

| 1

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➶

eidos

"However , not all agonists will activate IKKb through IKKa , such as with PKCh that can activate IKKb in the absence ofIKKa ( O'Mahony et al ., 2000 ) ."

25082354

Agonist affects DDX58

| 1

Agonist inhibits DDX58. 1 / 1

| 1

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➶

reach

"Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity.The RIG-I like receptor pathway is stimulated during RNA virus infection by interaction between cytosolic RIG-I and viral RNA structures that contain short hairpin dsRNA and 59 triphosphate (59ppp) terminal structure."

23633948

Afatinib affects RELA

1 |

Afatinib inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

22242139

Afatinib affects NFKB1

1 |

Afatinib inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

22242139

Adenosine affects NFKB1

| 1

Adenosine inhibits NFKB1. 1 / 1

| 1

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➶

reach

"The adenosine antagonist theophylline impairs p50 auditory sensory gating in normal subjects."

12377399

Adenosine affects JAK1

| 1

Adenosine inhibits JAK1. 1 / 1

| 1

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➶

reach

"Momelotinib (formerly known as CYT387) is a small-molecule, adenosine triphosphate-competitive inhibitor of JAK1 and JAK2."

28579852

Adenosine affects IFNB1

| 1

Adenosine inhibits IFNB1. 1 / 1

| 1

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➶

reach

"The adenosine generated by CD73 may mediate the inhibitory effects of IFN-beta on the transmigration of CD4+ T lymphocytes."

22291183

Adenosine affects IFIH1

| 1

Adenosine inhibits IFIH1. 1 / 1

| 1

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➶

reach

"It is noteworthy that another nucleotide modification, adenosine deamination (i.e. inosine) by the cellular enzyme ADAR1, significantly suppresses the MDA5 activity."

29534222

Adenine affects IFNB1

| 1

Adenine inhibits IFNB1. 1 / 1

| 1

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➶

reach

"Similarly, ADE infection suppressed TLR mediated signals and the secretion of IFN-beta, but increased the production of anti-inflammatory cytokines, such as IL-10, compared to DENV infection without antibodies."

25566258

Acteoside affects CASP1

| 1

Acteoside inhibits CASP1. 1 / 1

| 1

---

➶

medscan

"Acteoside attenuated interleukin-32-induced caspase-1 and nuclear factor-κB activations in THP-1 cells."

26453510

Acrylamide affects NLRP3

| 1

Acrylamide inhibits NLRP3. 1 / 1

| 1

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➶

reach

"This screening allowed the identification of 14, 2-(2-chlorobenzyl)-N-(4-sulfamoylphenethyl) acrylamide, which was able to concentration-dependently inhibit NLRP3 ATPase with an IC50 value of 74mum."

26990578

Acrolein affects STAT2

| 1

Acrolein inhibits STAT2. 1 / 1

| 1

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➶

reach

"Additionally, nuclear localization of phosphorylated STAT1 and STAT2 was greatly reduced demonstrating that acrolein effectively suppressed IFNalpha signaling and decreased activity of STAT1 and STAT2."

19345260

Acrolein affects STAT1

| 1

Acrolein inhibits STAT1. 1 / 1

| 1

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➶

reach

"Additionally, nuclear localization of phosphorylated STAT1 and STAT2 was greatly reduced demonstrating that acrolein effectively suppressed IFNalpha signaling and decreased activity of STAT1 and STAT2."

19345260

Acrolein affects NLRP3

| 1

Acrolein inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Acrolein induces NLRP3 inflammasome mediated pyroptosis and suppresses migration via ROS dependent autophagy in vascular endothelial cells."

30205151

Acrolein affects IRF3

| 1

Acrolein inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Acrolein inhibited NF-kappaB and IRF3 activation by LPS, but it did not inhibit NF-kappaB or IRF3 activation by MyD88, inhibitor kappaB kinase (IKK) beta, TRIF, or TNF-receptor-associated factor family member associated NF-kappaB activator (TANK)-binding kinase 1 (TBK1)."

18414004

Acridine orange free base affects IRF3

| 1

Acridine orange free base inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Tilorone, tilorone 874, acridine orange and geldanamycin blocked the activation of IRF-3 induced by poly (I : C) but not by LPS, indicating distinct signaling pathways are activated by these stimuli.IL-1 triggers signal through its cognate receptor and transduces it to MyD88, IRAK and TRAF6, as TLR4 does [1]."

12062447

Acetylsalicylic acid affects NLRP3

| 1

Acetylsalicylic acid inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"We also found that low concentration aspirin could inhibit the formation and activation of NLRP3 inflammasome and restore the expression of the endothelial tight junction protein zonula occludens-1/2 (ZO1/2)."

31384532

Acetylsalicylic acid affects MYD88

| 1

Acetylsalicylic acid inhibits MYD88. 1 / 1

| 1

---

➶

sparser

"Aspirin inhibits MyD88 and NF-κB in HSCs."

32283542

Acetylsalicylic acid affects ITCH

| 1

Acetylsalicylic acid inhibits ITCH. 1 / 1

| 1

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➶

reach

"The effect of topical aspirin and its model vehicle dichloromethane on itch experimentally induced with histamine was studied in 16 subjects, using a visual analogue scale and computerized aspirin, but not its vehicle, significantly reduced itch duration (p = 0.001) and decreased itch magnitude as measured with a visual analogue scale (p < 0.04)."

9059677

Acetylsalicylic acid affects FOS

| 1

Acetylsalicylic acid inhibits FOS. 1 / 1

| 1

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➶

reach

"Furthermore, administration of an analgesic dose of acetylsalicylic acid (125 mg/kg) failed to reduce either c-Fos or total Fos induction after the acetic acid insult (unpublished observation)."

9698203

Acetylsalicylic acid affects CHUK

| 1

Acetylsalicylic acid inhibits CHUK. 1 / 1

| 1

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➶

reach

"The IKK inhibitors parthenolide and aspirin blocked the activities of infection induced IKKalpha and IKKbeta, leading to attenuation of nuclear translocation of NF-kappaB."

15618150

Acetylcholine affects RELA

| 1

Acetylcholine inhibits RELA. 1 / 1

| 1

---

➶

reach

"ACh at concentrations of 0.1-10 microM inhibited this TNF-alpha and NF-kappaB p65 activation in a concentration dependent manner."

23936328

Acetylcholine affects NLRP3

| 1

Acetylcholine inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Together, these findings reveal a novel neurotransmitter mediated signaling pathway : acetylcholine translocates into the cytoplasm of immune cells during inflammation and inhibits NLRP3 inflammasome activation by preventing mitochondrial DNA release."

24849809

Acetylcholine affects NFKB1

| 1

Acetylcholine inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Previous studies indicated that the combination of acetylcholine and the alpha7nAChR can inhibit the NF-KB transcription factor and activate the Jak2-STAT3 signaling pathway."

25396421

Acetylcholine affects MAPK14

| 1

Acetylcholine inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"PMA- and acetylcholine-inducedMMP1expression were strongly diminished by inhibiting Src and abolished by concurrently inhibiting both p38-α/β and Src, indicating that Src mediates the cross-talk between PKC-α and EGFR signaling."

28008134

Acetohydroxamic acid affects ITCH

| 1

Acetohydroxamic acid inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Lactic acid, a monocarboxylic acid AHA, has been widely used to relieve itch as an ingredient of moisturizers for AD patients XREF_BIBR."

27274633

Acetic acid affects NFKBIA

| 1

Acetic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Mechanistically, we found that bornyl acetate could suppress activation of the IkappaBalpha and NF-kappaB signaling pathway."

29655164

Acetic acid affects MAVS

| 1

Acetic acid inhibits MAVS. 1 / 1

| 1

---

➶

reach

"The compound p-hydroxycinnamyl acetate strongly inhibited Staphylococcusaureus strain VISA (MIC 39mug/ml) followed by trans-p-coumaryl diacetate and 1 '-hydroxychavicol acetate with MIC value of 156mug/ml."

23266278

Acetic acid affects ITCH

| 1

Acetic acid inhibits ITCH. 1 / 1

| 1

---

➶

reach

"14 A small pilot study in patients with pruritus from undefined etiologies demonstrated that topical application of hydrocortisone acetate 2.5% and pramoxine hydrochloride 1% in a hydrolipid lotion reduced pruritus by 30% from baseline as rated by patients using the visual analog scale within 24 hours of initiation of therapy."

21767774

Acetazolamide(1-) affects MAVS

| 1

Acetazolamide(1-) inhibits MAVS. 1 / 1

| 1

---

➶

reach

"Although the use of acetazolamide decreased the VISA inflammatory score of patients in the case group, no significant difference was observed between the VISA inflammatory score of patients in the two groups (P = 0."

24822231

Acetate affects MAVS

| 1

Acetate inhibits MAVS. 1 / 1

| 1

---

➶

sparser

"The compound p-hydroxycinnamyl acetate strongly inhibited Staphylococcusaureus strain VISA (MIC 39μg/ml) followed by trans-p-coumaryl diacetate and 1'-hydroxychavicol acetate with MIC value of 156μg/ml."

23266278

Acetate affects JUN

| 1

Acetate inhibits JUN. 1 / 1

| 1

---

➶

sparser

"Surprisingly, uranyl acetate inhibited two nonzinc finger DNA-binding proteins, AP1 and NF-kappaB, to a similar extent, and zinc finger inhibition was reduced in the presence of bovine serum albumin."

17432879

Acetaldehyde affects NFKBIA

| 1

Acetaldehyde inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Acetaldehyde increased IkappaB-alpha kinase activity and decreased IkappaB-alpha after 10 min of exposure, with recovery towards control levels at 20 min."

15550448

Acetaldehyde affects JUN

| 1

Acetaldehyde inhibits JUN. 1 / 1

| 1

---

➶

reach

"Ethanol- and acetaldehyde induced activation of activator protein-1 and MAP kinases was blocked by the antioxidant N-acetyl-cysteine, suggesting a role of oxidative stress in the signal transduction."

12065697

Acetaldehyde affects CASP1

| 1

Acetaldehyde inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Substrate based inhibitor design has lead to the discovery of several potent C-terminal peptide aldehyde inhibitors6 of caspase- 1 based on the pro-IL-l [3 cleavage site TyrValHisAspll6-Ala117."

9873617

Acenaphthoquinone affects CASP1

| 1

Acenaphthoquinone inhibits CASP1. 1 / 1

| 1

---

➶

reach

"This result shows that AQ inhibits cytotoxicity upstream of caspase-1 activation."

26310922

Acceptor affects NLRP3

| 1

Acceptor inhibits NLRP3. 1 / 1

| 1

---

➶

sparser

"Finally, the mechanisms by which compounds containing sulfonylurea or Michael acceptor moieties cause NLRP3 inhibition will have to be defined, which may open new possibilities for potential future therapeutic applications of these molecules."

27508077

Acarbose(1+) affects NLRP3

| 1

Acarbose(1+) inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"It was found that HG significantly induced the formation and activation of NLRP3 inflammasome, which was markedly blocked by acarbose treatment."

31541678

Acadesine affects MAPK14

| 1

Acadesine inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Recently, we showed that 8-chloro-cyclic AMP and 5-aminoimidazole-4-carboxamide ribonucleoside inhibited cancer cell growth through the activation of AMPK and p38 MAPK."

23018889

Abacavir affects IKBKB

| 1

Abacavir inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"These results suggest that AC, ABC and AB '' ' C suppress NF-kappaB activity downstream of IKKbeta."

29139553

Abacavir affects IFNB1

| 1

Abacavir inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Lenalidomide, a drug showing clinical activity against DLBCL, antagonizes a central regulatory hub in ABC DLBCL governed by IRF4 and SPIB, which together suppress IFNbeta while augmenting NFkappaB activity."

23243601

[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE affects MAPK14

1 |

[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE affects MAPK14

1 |

[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

[4-[[4-(1-benzothiophen-2-yl)-2-pyrimidinyl]amino]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone affects CHUK

1 |

[4-[[4-(1-benzothiophen-2-yl)-2-pyrimidinyl]amino]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

16236504

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone affects TYK2

1 |

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone affects TBK1

1 |

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone affects RIPK1

1 |

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone inhibits RIPK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone affects MAPK8

1 |

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone affects MAP3K7

1 |

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone affects JAK1

1 |

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone affects IKBKE

1 |

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone affects IKBKB

1 |

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone inhibits IKBKB. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone affects CHUK

1 |

[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

[4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone affects MAPK14

1 |

[4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

14667219

Z-Val-Ala-Asp fluoromethyl ketone affects CASP1

1 |

Z-Val-Ala-Asp fluoromethyl ketone inhibits CASP1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

XL019 affects TYK2

1 |

XL019 inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

23127890

XL019 affects IKBKB

1 |

XL019 inhibits IKBKB. 1 / 1

1 |

---

➶

tas

No evidence text available

23127890

XL-019 affects TYK2

1 |

XL-019 inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

23127890

XL-019 affects JAK1

1 |

XL-019 inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

23127890

XL-019 affects IKBKB

1 |

XL-019 inhibits IKBKB. 1 / 1

1 |

---

➶

tas

No evidence text available

23127890

Vitamin E affects RELA

1 |

Vitamin E inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

22223226

Val-Ser affects JAK1

| 1

Val-Ser inhibits JAK1. 1 / 1

| 1

---

➶

reach

"Similarly, the Vs domain on its own showed a partial ability to block type I IFN action in the reporter gene assay, presumably due to its ability to bind to and inhibit the Jak1 and Tyk2 kinases, but could not prevent the function of type I IFN in inducing the antiviral state."

24158397

Val-Ala affects NLRP3

| 1

Val-Ala inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"An Ad5 mutant virus defective in expression of the non coding VA RNAI failed to inhibit the NLRP3 inflammasome and in addition displayed formation of ASC specks and increased cell lysis."

31849970

Val-Ala affects IFNB1

| 1

Val-Ala inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Examination of additional microglial chemokine and antiviral genes (XREF_FIG and XREF_FIG, and XREF_FIG and XREF_FIG, respectively) demonstrated that IP-10, IFNbeta, IDO and viperin mRNA were all strongly inhibited by TSA and VA, whereas SB216763 had much less and insignificant effects."

20157787

VX-745 affects IFNB1

| 1

VX-745 inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Interestingly, VX745 also reduced IFN-beta mRNA induction in MSK1/2 knockout BMDMs, while a combination of JNK-In-8 and VX745 suppressed IFN-beta mRNA to a greater extent than either inhibitor alone (XREF_FIG)."

27795299

VX-702 affects MAPK14

1 |

VX-702 inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

VS-5584 affects TYK2

1 |

VS-5584 inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

URMC-099 affects IKBKB

1 |

URMC-099 inhibits IKBKB. 1 / 1

1 |

---

➶

tas

No evidence text available

24044867

URMC-099 affects CHUK

1 |

URMC-099 inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

24044867

U 78517F affects RELA

1 |

U 78517F inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

16478757

Tyr-Ile affects NFKBIA

| 1

Tyr-Ile inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"The results showed that the expression of p-JNK, P-ERK, p-P38, p-IkappaBalpha, and p-NF-kappaBp65 in the liver tissue was increased after the injection of CCL 4, while the Yi Guan Jian and silymarin could significantly reduce p-JNK, P-ERK, p-P38, p-IkappaBalpha, and p-NF-kappaBp65 in liver tissue."

30891081

Trypsin affects JUN

| 1

Trypsin inhibits JUN. 1 / 1

| 1

---

➶

reach

"This is consistent with our model, where 27/198 (13.6%) amino acids are in alpha -helices and 59/198 (29.8%) in a beta -sheet conformation.The products of trypsin degradation of Jun a 3 were separated by HPLC, and the fractions were tested for reactivity with pooled patient serum IgE by dot blotting."

10969020

Trypsin affects ITCH

| 1

Trypsin inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Strikingly, compound 48/80, CQ, ET-1, serotonin, SLIGRL and trypsin mediated itch were all greatly reduced in TLR3 knockout mice along with formalin second phase pain and capsaicin induced secondary hyperalgesia."

26385480

Trypsin affects IKBKB

| 1

Trypsin inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Additionally, inhibitors of PKC partially reduced trypsin stimulated IKK alpha activity but abolished that of IKK beta, whereas DN-PKC alpha but not DN-PKC zeta substantially reduced trypsin stimulated Flag-IKK beta activity."

11413129

Trp-Leu-Leu affects TRAF6

| 1

Trp-Leu-Leu inhibits TRAF6. 1 / 1

| 1

---

➶

reach

"In the present study, wLL inhibited the activation of TRAF-6 but did not show effect in MAPKs signaling pathway."

30915145

Trp-Glu affects CASP1

| 1

Trp-Glu inhibits CASP1. 1 / 1

| 1

---

➶

reach

"italica (WE) significantly reduced thymic stromal lymphopoietin (TSLP) secretion and caspase-1 activity on activated HMC-1 cells."

32041439

Trp-Ala affects IRF3

| 1

Trp-Ala inhibits IRF3. 1 / 1

| 1

---

➶

reach

"In addition overexpression of NSP1 from OSU, KU, DS-1 or Wa strains also resulted in degradation of MAVS irrespective of their ability to degrade IRF3."

24643253

Trolox affects FOS

| 1

Trolox inhibits FOS. 1 / 1

| 1

---

➶

medscan

"We found that Trolox down-regulated the induction by RANKL of c-Fos protein by suppressing its translation."

19299513

Triton X-100 affects RELA

| 1

Triton X-100 inhibits RELA. 1 / 1

| 1

---

➶

reach

"Cells were fixed with 4% paraformaldehyde for 30min, permeabilized in 0.2% Triton X-100 for 30min, washed with PBS, blocked with 1% BSA/0.05% Triton X-100 for 30min, and further incubated with rabbit polyclonal antibody against NF-kappaB p65 (1:100 dilution) in blocking buffer overnight."

28629334

Triptolide affects TICAM1

| 1

Triptolide inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"Triptolide can suppress TLR-induced NF-κB activation and downregulate TLR4 and TRIF proteins (Premkumar et al., 2010)."

32300254

Triptolide affects STAT1

| 1

Triptolide inhibits STAT1. 1 / 1

| 1

---

➶

medscan

"The results demonstrated that triptolide inhibited the expression of IFN-γRα (IC₅₀  = 1.37 × 10⁻⁸ M), phospho-Janus kinase2 (IC₅₀  = 2.82 × 10⁻⁹ M) and phospho-signal transducer and activator of transcription 1 (IC₅₀  = 1.29 × 10⁻⁹ M) in HaCaT cells."

21433155

Triptolide affects MAP3K7

| 1

Triptolide inhibits MAP3K7. 1 / 1

| 1

---

➶

medscan

"We discover that Triptolide inhibits TAK1 kinase activity by interfering with the formation of the TAK1-TAB1 complex, and the binding affinity of Triptolide to TAB1 correlates highly with the inhibitory activity of Triptolide against MAPK pathway activation in macrophages."

24462677

Triazolopyridine affects MAPK14

1 |

Triazolopyridine inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

Tofacitinib affects TYK2

1 |

Tofacitinib inhibits TYK2. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

Tofacitinib affects JAK1

1 |

Tofacitinib inhibits JAK1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

Thr-Thr affects FOS

| 1

Thr-Thr inhibits FOS. 1 / 1

| 1

---

➶

reach

"Moreover, TT reduced the expression levels of the core transcription elements, nuclear factor of activated T-cells cytoplasmic 1 (NFATc1) and c-Fos."

31286602

Thr-Ala-Ser affects DDX58

| 1

Thr-Ala-Ser inhibits DDX58. 1 / 1

| 1

---

➶

reach

"Disruption of the TAS motif apparently impaired binding with poly I : C, whereas binding with short dsRNA was unaffected, suggesting that poly I : C interacts with additional sites, including the TAS motif of the helicase domain.We produced a full-length recombinant RIG-I, purified it to homogeneity, and subjected it to biochemical analyses."

18242112

Tegaserod affects FOS

| 1

Tegaserod inhibits FOS. 1 / 1

| 1

---

➶

reach

"Compared to saline, tegaserod significantly inhibited AWR in group H (0.4 mL : from 2.0 to 0.5; 0.8 mL : from 3.5 to 1.5; 1.2 mL : from 4.0 to 3.0, P < 0.01), but had no significant effect on group C. Tegaserod dose-dependently attenuated the number of c-Fos positive neurons in limbic structures, anterior cingulate cortex (ACC) showed the greatest attenuation."

15334681

Tarenflurbil affects IKBKG

1 |

Tarenflurbil inhibits IKBKG. 1 / 1

1 |

---

➶

drugbank

No evidence text available

Talmapimod affects MAPK14

1 |

Talmapimod inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

TUDCA affects MAPK8

| 1

TUDCA inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"Also, cells from PGMN pregnancies show higher JNK1 phosphorylation in response to tunicamycin, a response blocked by TUDCA, suggesting that ER stress increases JNK1 also in cells from PGMN pregnancies.A preferential nuclear localization of ATF6 is considered a marker of ER stress [13, 50, 59], as reported in HUVECs [64]."

30006153

TUDCA affects IFNB1

| 1

TUDCA inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Decreased levels of ER stress post TUDCA treatment resulted in decreased BIP and GRP78, IRE1, XBP1, and Atg9a expression and increased IFNbeta production by aged macrophages in response to S. pne infection."

24670807

TOP-1288 affects MAPK14

1 |

TOP-1288 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

TOAC affects TRIM25

| 1

TOAC inhibits TRIM25. 1 / 1

| 1

---

➶

reach

"However, the HFD+E tOAc group decreased the weights of both EFP and liver by 56% (p < 0.05) and 20% (p < 0.01) compared with HFD alone."

28824323

THZ1 affects STAT1

| 1

THZ1 inhibits STAT1. 1 / 1

| 1

---

➶

reach

"THZ1 decreases the activity of STAT1 and STAT5."

28134252

TANZISERTIB affects MAPK8

1 |

TANZISERTIB inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

22244937

TAK-632 affects MAPK14

1 |

TAK-632 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

23906342

Sulfonylurea affects NLRP3

| 1

Sulfonylurea inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Sulfonylurea drugs seem to specifically inhibit the triggering step of NLRP3 activation without affecting the NF-kappaB signaling related priming step or the activation of other inflammasomes XREF_BIBR, XREF_BIBR."

27508077

Soyasaponin A1 affects TRAF6

| 1

Soyasaponin A1 inhibits TRAF6. 1 / 1

| 1

---

➶

eidos

"Furthermore , soyasaponin A1 ( 20 mumol / L ) , A2 ( 40 mumol / L ) , I ( both 20 and 40 mumol / L ) and ST2825 significantly decreased the TRAF6 levels ( p < 0.05 ) ."

32493316

Solcitinib affects JAK1

1 |

Solcitinib inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

Sodium salicylate affects IKBKB

1 |

Sodium salicylate inhibits IKBKB. 1 / 1

1 |

---

➶

ctd

No evidence text available

10480951

Sodium salicylate affects CASP1

1 |

Sodium salicylate inhibits CASP1. 1 / 1

1 |

---

➶

ctd

No evidence text available

17561093

Sildenafil affects IFNB1

| 1

Sildenafil inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Sildenafil reversed the detrimental effect of IFN-beta on the cardiovascular system."

28316997

Sildenafil citrate affects NFKB1

| 1

Sildenafil citrate inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Sildenafil citrate also suppressed the AGEs-BSA-induced stimulation of ROS production (XREF_FIG) and NFkB activity (XREF_FIG)."

25371895

Shikonin affects RIPK1

| 1

Shikonin inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"The same sensitizing effect by knockdown of RIP1 was obtained in HL60 cells treated with 1.25 muM shikonin for 12 h (XREF_FIG)."

22837689

Shikonin affects IKBKB

| 1

Shikonin inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Shikonin Directly Suppresses IKKbeta Activity."

23762128

Ser-Met affects TICAM1

| 1

Ser-Met inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"cIAP1/2 dependent inflammatory cytokine induction by TLR4 was unique to the MyD88 dependent response, as SM pretreatment inhibited LPS induced inflammatory cytokines and chemokines in Trif Lps2 and Lps2 BMDMs, which were impaired in induction of IFN related genes (XREF_FIG, XREF_SUPPLEMENTARY)."

19898473

Ser-Met affects MAP3K7

| 1

Ser-Met inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"In bone marrow derived macrophages (BMDMs) and the mouse macrophage line RAW264.7, SM pretreatment inhibited activation of the MAPK kinase kinase (MAP3K) TAK1, but not IkappaB kinase (IKK), by TLR4 and TLR2 ligation (XREF_FIG, XREF_SUPPLEMENTARY)."

19898473

Ser-Met affects IRF3

| 1

Ser-Met inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Chen Z, Rijnbrand R, Jangra RK, Devaraj SG, Qu L, Ma Y, Lemon SM, Li K: Ubiquitination and proteasomal degradation of interferon regulatory factor-3 induced by Npro from a cytopathic bovine viral diarrhea virus."

20538505

Ser-Met affects IFNB1

| 1

Ser-Met inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Similarly, SM treatment decreased IFNbeta production by aged macrophages in response to cGAMPs (XREF_SUPPLEMENTARY)."

24670807

Ser-Leu affects NFKBIA

| 1

Ser-Leu inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"The SL and SH group only could down-regulate 7 genes (Rasgrp1, Map3k8, Nfkbie, Nfkbib, Nfkbia, Pik3r5, and Pik3cg) and 4 genes (Map3k8, Nfkbie, Nfkbib, and Pik3r5), respectively, as shown in XREF_FIG and XREF_TABLE."

24527057

Ser-Leu affects MYD88

| 1

Ser-Leu inhibits MYD88. 1 / 1

| 1

---

➶

reach

"The SL and SH only could down-regulate 9 genes (MyD88, Mapk8, Mapk13, Tnf, Il1b, Csf2, Cxcr2, Ccl5, and Il12a) and 8 genes (MyD88, Mapk8, Mapk13, Tnf, Il1b, Csf2, Cxcr2, and Il12a), respectively, as shown in XREF_FIG and XREF_TABLE."

24527057

Ser-Leu affects MAPK8

| 1

Ser-Leu inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"The SL and SH only could down-regulate 9 genes (MyD88, Mapk8, Mapk13, Tnf, Il1b, Csf2, Cxcr2, Ccl5, and Il12a) and 8 genes (MyD88, Mapk8, Mapk13, Tnf, Il1b, Csf2, Cxcr2, and Il12a), respectively, as shown in XREF_FIG and XREF_TABLE."

24527057

Ser-Leu affects IFNB1

| 1

Ser-Leu inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"SL inhibits IFN-beta production in plasmacytoid dendritic cells when TLR2, TLR7 and TLR9 pathways are stimulated."

27547699

Ser-Ala affects RELA

| 1

Ser-Ala inhibits RELA. 1 / 1

| 1

---

➶

reach

"Our data thus far indicate that ubiquitination of RelA SA proteins does not trigger RelA degradation possibly implying that RelA SA mutants might not be targeted by K48 linked polyubiquitination."

22261743

Ser-Ala affects NFKBIA

| 1

Ser-Ala inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Additionally, inhibition of miR-300 abrogated the repression of IkappaBalpha by SA."

31048002

Salvianolic acid A affects MAPK14

| 1

Salvianolic acid A inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Importantly, Salvianolic acid A effectively suppressed ischemia/reperfusion-induced activation of p38 MAPK signaling and increase of VLDL receptor expression."

24662412

SU6656 affects IKBKB

| 1

SU6656 inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Pre-incubation of the SFK inhibitor SU6656 impaired the activation of c-Kit, IKK2 and STATs but enhanced the activation of PKB and Akt and did not affect the proliferation (XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY)."

26353931

SU-014813 affects TBK1

1 |

SU-014813 inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

SU-014813 affects MAP3K7

1 |

SU-014813 inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

SU-014813 affects CHUK

1 |

SU-014813 inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

SN-38 affects NFKBIA

| 1

SN-38 inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Human non small cell lung carcinoma (NSCLC-3) cells transfected with a control vector (NSCLC-3 and neo) or a vector containing dominant negative IkappaBalpha (NSCLC-3 and mIkappaBalpha) were treated with SN-38 for 1 h followed by PS-341 for 4 h (SN-38 --> PS-341), or with either drug alone."

16827119

SILMITASERTIB affects TBK1

1 |

SILMITASERTIB inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

21174434

SGN-30 affects NFKB1

1 |

SGN-30 inhibits NFKB1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

SD-06 affects MAPK14

1 |

SD-06 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

20227876

SD-0006 affects MAPK14

1 |

SD-0006 inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

SB202190 affects NLRP3

| 1

SB202190 inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"PDTC (Pyrrolidinedithiocarbamic acid), SB202190 and Z-YVAD-FMK were used to block the MyD88 and NF-kappaB, MAPKs and p38 and NLRP3 and Caspase -1 pathway, respectively."

28668606

SB202190 affects MYD88

| 1

SB202190 inhibits MYD88. 1 / 1

| 1

---

➶

reach

"PDTC (Pyrrolidinedithiocarbamic acid), SB202190 and Z-YVAD-FMK were used to block the MyD88 and NF-kappaB, MAPKs and p38 and NLRP3 and Caspase -1 pathway, respectively."

28668606

SB202190 affects MAPK8

| 1

SB202190 inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"As shown in XREF_FIG (MTT assay) and XREF_FIG (annexin-V and PI double staining), SP600125 (an inhibitor of JNK-1, -2 and -3), SB202190 (an inhibitor of p38 MAPK-beta), and U0126 (an inhibitor of MEK1/2) each significantly reduced glutamate induced cell death in a concentration dependent manner."

20542495

SB202190 affects MAPK14

| 1

SB202190 inhibits MAPK14. 1 / 1

| 1

---

➶

reach

"In several human colon cancer cell lines the inhibition of MAPK14 by SB202190 induced growth arrest and autophagic cell death [XREF_BIBR]."

26373535

SB202190 affects MAP3K7

| 1

SB202190 inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"SB202190 (5 muM) attenuated TAK1 and TAB2-induction of the GAL4-CHOP reporter by approximately 50%, confirming that the response was, at least in part, p38 dependent."

22549017

SB-202190 affects MAPK8

| 1

SB-202190 inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"To investigate downstream signaling through mitogen-activated protein kinases , experiments were performed in the presence of selective inhibitors of MEK1/2 (U0126), p38 MAP kinase (SB202190), or JNK (JNK inhibitor VIII, which inhibits JNK1/2/3)."

25050597

SB 431542 affects TRIM25

| 1

SB 431542 inhibits TRIM25. 1 / 1

| 1

---

➶

reach

"In order to further confirm the involvement of TGF-beta signaling, MKN-28 cells with a lower expression of TRIM25 was overexpressed with TRIM25 and treated with TGF-beta inhibitor (SB-431542, XREF_FIG)."

26754079

SB 431542 affects PYCARD

| 1

SB 431542 inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"As expected, ASC myofibroblastic differentiation induced by TGFbeta1 was reversed by SB431542."

28592806

SB 203580 affects TRAF6

| 1

SB 203580 inhibits TRAF6. 1 / 1

| 1

---

➶

reach

"Our results that SB203580 reduced IL-1 (TRAF6)-induced AP-1 activation, but not so much of NF-kappaB activation indicate that p38 MAP kinase play a more important role in AP-1 activation than NF-kappaB activation leading to the IL-8 mRNA expression."

11367542

SB 203580 affects NLRP3

| 1

SB 203580 inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"SB203580 pretreatment significantly reversed the LPS induced upregulation of NLRP3, cleaved caspase-1 and TLR2, indicating a beneficial role of blockage of the p38 MAPK signaling pathway in reducing the formation of the NLRP3 inflammasome and pyroptosis."

30152849

SB 202190 affects STAT1

| 1

SB 202190 inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Furthermore, nonspecific off-target effects of SB 202190 on the FPV induced STAT1 Ser 727 phosphorylation were ruled out by using a second p38 specific inhibitor, SB 203580 (XREF_FIG B, right, upper panel, lanes 6 and 9)."

24189062

S-nitroso-N-acetyl-D-penicillamine affects NLRP3

| 1

S-nitroso-N-acetyl-D-penicillamine inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Furthermore, S-nitroso-N-acetylpenicillamine (SNAP), an NO donor, markedly inhibited NLRP3 inflammasome activation, whereas the AIM2 and NLRC4 inflammasomes were only partially inhibited by SNAP."

23100513

S-adenosyl-L-methionine affects NFKBIA

| 1

S-adenosyl-L-methionine inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"As shown in Figure 6, the amount of IkappaBalpha decreased 2.5-fold in cells treated with 0.5 mmol/L SAMe and fivefold with 1.0 mmol/L SAMe in HepG2."

17591973

S-adenosyl-L-methioninate affects IKBKB

| 1

S-adenosyl-L-methioninate inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Interestingly, SAM directly inhibited the kinase activity of IKK-beta in vitro."

20208423

S-[2,3-bis(palmitoyloxy)propyl]-Cys-Ser-Lys-Lys-Lys-Lys affects RELA

| 1

S-[2,3-bis(palmitoyloxy)propyl]-Cys-Ser-Lys-Lys-Lys-Lys inhibits RELA. 1 / 1

| 1

---

➶

reach

"Deletion of SOCS3 had a modest enhancing effect on Pam2CSK4 induced NF-kappaB p65 and ERK1/2 activation (XREF_FIG), but did not affect Pam2CSK4 induced mRNA expression of IL-1beta, IL-6, IL-12p40, IL-23p19 or iNOS (XREF_FIG)."

22925925

S-Ruxolitinib affects MAP3K7

1 |

S-Ruxolitinib inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

RvE1 affects NFKB1

| 1

RvE1 inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"In addition, RvE1 seems to bind to the GPCR receptor ChemR23 and inhibit NFkB signalling through a mechanism that involves phosphorylation rather than mobilization of calcium or cAMP [XREF_BIBR]."

18554314

RvD2 affects NLRP3

| 1

RvD2 inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In vivo, in a self resolving zymosan A induced peritonitis model, RvD2 blocked the NLRP3 inflammasome leading to reduced release of IL-1beta into the exudates, repression of osteopontin, and MCP-1 expression and induction of M2 markers of resolution (i.e., CD206 and arginase-1) in peritoneal macrophages."

29601102

RvD1 affects STAT1

| 1

RvD1 inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Of interest, RvD1 blocked STAT-1 and its target inflammatory genes (i.e. CXCL9) as well as persistent STAT3 activation without affecting the IL-10 anti-inflammatory response characterized by inhibition of IL-6, IL-1beta, IL-8 and TNFalpha."

27647830

RvD1 affects RELA

| 1

RvD1 inhibits RELA. 1 / 1

| 1

---

➶

reach

"Our study of signalling pathways revealed that RvD1 suppressed IL-1beta-induced activation of NF-kappaB and p65, p38 and MAPK and JNK (1/2)."

27056390

RvD1 affects NLRP3

| 1

RvD1 inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"These findings indicate that RvD1 may inhibit the NLRP3 inflammasome and the NF-kappaB signaling pathway and may contribute to attenuation of the early stage of DR. The disruption of the BRB occurs in the early stage of STZ treated retinopathy [XREF_BIBR]."

28465656

RvD1 affects NFKBIA

| 1

RvD1 inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"RvD1 markedly decreased airway eosinophilia and mucus metaplasia, in part by decreasing IL-5 and IkappaBalpha degradation."

22802419

Ro 320-1195 affects MAPK14

1 |

Ro 320-1195 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

16509574

Ro 31-8220 affects RELA

| 1

Ro 31-8220 inhibits RELA. 1 / 1

| 1

---

➶

medscan

"Adenosine 5'-triphosphateγS-induced p38 MAPK, p42/p44 MAPK, and NF-κB p65 activation were inhibited by Gö6976, Ro-318220, GF109203X, or rottlerin."

23680674

Ro 31-8220 affects MAPK8

1 |

Ro 31-8220 inhibits MAPK8. 1 / 1

1 |

---

➶

ctd

No evidence text available

11756236

Rimonabant affects FOS

1 |

Rimonabant inhibits FOS. 1 / 1

1 |

---

➶

ctd

No evidence text available

15280883

Rifampicin affects ITCH

| 1

Rifampicin inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Rifampicin (RMP) significantly reduced itch intensity and ATX activity in patients with pruritus not responding to bile salt sequestrants."

22473838

Ricin affects RIPK1

| 1

Ricin inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"An example of this is ricin, which can be classified as both lectin and type II ribosome inactivating protein (RIP) [16] ."

| PMC

Rhein affects RELA

1 |

Rhein inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

21457705

Rhein affects NLRP3

| 1

Rhein inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In a third study, Rhein, a traditional Chinese medicine (lipophilic anthraquinone) found in medicinal herbs that has antiviral activities, inhibited RSV-induced activation of the NLRP3 inflammasome and production of lung IL-33 in mice [115]."

32397226

Rhein affects NFKB1

1 |

Rhein inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

21457705

Resiquimod affects TLR7

1 |

Resiquimod inhibits TLR7. 1 / 1

1 |

---

➶

drugbank

No evidence text available

16081189

Ralimetinib affects MAPK14

1 |

Ralimetinib inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

RG-1530 affects TYK2

1 |

RG-1530 inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

RG-1530 affects MAPK14

1 |

RG-1530 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

RES affects JAK1

| 1

RES inhibits JAK1. 1 / 1

| 1

---

➶

reach

"We also observed that RES inhibited the activation of constitutively active JAK1, JAK2, and Src kinases in RCC cells."

26911335

RALIMETINIB affects MAPK14

1 |

RALIMETINIB inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

RALIMETINIB MESYLATE affects MAPK14

1 |

RALIMETINIB MESYLATE inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

Pyrazolanthrone affects MAPK8

1 |

Pyrazolanthrone inhibits MAPK8. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

Pyocyanin affects NLRP3

| 1

Pyocyanin inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Pyocyanin inhibits the NLRP3 inflammasome through the production of ROS and RNS."

29414783

Pseudoephedrine affects NFKB1

1 |

Pseudoephedrine inhibits NFKB1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

21631396

Pseudoephedrine affects JUN

1 |

Pseudoephedrine inhibits JUN. 1 / 1

1 |

---

➶

drugbank

No evidence text available

21631396

Pro-Val affects NFKBIA

| 1

Pro-Val inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Whether PV also induces IkappaBalpha degradation and whether degradation is required for NF-kappaB activation are not understood."

10722693

Pro-Val affects IRF3

| 1

Pro-Val inhibits IRF3. 1 / 1

| 1

---

➶

reach

"As shown by Kotla S et al.30, PV blocks the activation of IRF-3 but does not inhibit MDA-5 or MAVS to inhibit IFN-I expression."

29700351

Pro-Val affects IFIH1

| 1

Pro-Val inhibits IFIH1. 1 / 1

| 1

---

➶

reach

"Perplexingly, this cleavage event may enhance type I IFN signaling as induction of IFNbeta was reduced in PV infected cells treated with a caspase inhibitor to block MDA5 cleavage [XREF_BIBR]."

23764548

Pro-Val affects CASP1

| 1

Pro-Val inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Similarly, FCA and PV blocked mature IL-1beta production and Casp1 cleavage following S. typhimurium infection."

28533778

Pro-Gln affects NFKBIA

| 1

Pro-Gln inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"This phenomenon indicated that PQ induced degradation of IkappaB-alpha, and thus NF-kappaB p65 was released and transferred to the nucleus, resulting in activation of the downstream proinflammatory gene."

28480221

Pro-Gln affects IRF3

| 1

Pro-Gln inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Further, amlexanox treatment alleviates PQ induced ALI by inhibiting the TBK1-NF-kappaB and IRF3 signalling pathway."

32763286

Pravastatin affects NFKBIA

| 1

Pravastatin inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Pravastatin inhibit the activator protein-1 activity, but did not inhibit the activation of IkappaB-alpha."

11606315

Pravastatin affects JUN

| 1

Pravastatin inhibits JUN. 1 / 1

| 1

---

➶

reach

"Pravastatin inhibit the activator protein-1 activity, but did not inhibit the activation of IkappaB-alpha."

11606315

Pralnacasan affects CASP1

1 |

Pralnacasan inhibits CASP1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

17845807

Poly IC affects IFIH1

| 1

Poly IC inhibits IFIH1. 1 / 1

| 1

---

➶

reach

"Poly IC induced antiviral responses were significantly reduced in both RIG-I and MDA5 null MEFs, with a greater inhibition observed in MDA5 -/- MEFs."

20360967

Poly IC affects DDX58

| 1

Poly IC inhibits DDX58. 1 / 1

| 1

---

➶

reach

"Poly IC induced antiviral responses were significantly reduced in both RIG-I and MDA5 null MEFs, with a greater inhibition observed in MDA5 -/- MEFs."

20360967

Poly I:C affects TICAM1

| 1

Poly I:C inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"Enforced expression of miR27a inhibitor failed to bring about Mtb mediated negative regulation of TICAM1, while its mimic was sufficient to abrogate Poly I : C induced TICAM1."

29449840

Poly I:C affects RELA

| 1

Poly I:C inhibits RELA. 1 / 1

| 1

---

➶

reach

"This is consistent with the observation that AhR suppressed activation of p65 by Poly I : C and TNF-alpha, but not basal p65 activity."

25201625

Poly I:C affects DDX58

| 1

Poly I:C inhibits DDX58. 1 / 1

| 1

---

➶

reach

"In contrast to when RIG-I was present, when RIG-I was silenced H3N2 did not induce RIG-I mRNA and protein, and Poly I : C induced RIG-I mRNA and protein production was attenuated compared to RIG-I-intact cells (XREF_FIG)."

22396801

Poly I:C affects CHUK

| 1

Poly I:C inhibits CHUK. 1 / 1

| 1

---

➶

reach

"As shown in XREF_FIG B, activation of IKKalpha by CpG-DNA were reduced when cells were transfected with increasing amounts of TRAF6-C, but activation of IKKalpha by Poly I : C was not affected by TRAF6-C (XREF_FIG B)."

10952730

Phe-Asp affects RELA

| 1

Phe-Asp inhibits RELA. 1 / 1

| 1

---

➶

reach

"Interestingly, FD treatment markedly blocked the accumulation of p65 in the nucleus induced by IL-1beta (P < 0.05; Fig."

27306439

Phe-Asp affects MYD88

| 1

Phe-Asp inhibits MYD88. 1 / 1

| 1

---

➶

sparser

"And compared with BLM group, the level of Casp1 was significantly inhibited by FD or Cp1 inhibitor ( P < 0.01 each), the expressions of IL‐1Rl, MyD88 were markedly inhibited by FD or IL‐1Ra ( P < 0.01 each)."

27306439

Pepstatin affects CASP1

| 1

Pepstatin inhibits CASP1. 1 / 1

| 1

---

➶

medscan

"This 20-kDa product was produced independently of NLRP3 and caspase-1 but was inhibited by the cathepsin D inhibitor pepstatin A."

24022484

Pentoxifylline affects RELA

1 |

Pentoxifylline inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

16317704

Paeonol affects RELA

| 1

Paeonol inhibits RELA. 1 / 1

| 1

---

➶

eidos

"The results showed that as compared with model group , paeonol significantly reduced aortic plaque area and lesion degree in rats , decreased the level of serum TNF-alpha , IL-6 and VCAM-1 in the rats and enhanced the relative expression level of caveolin-1 , decreased p65 expression conversely ( P &lt; 0.05 or P &lt; 0.01 ) ."

32627492

Pacritinib affects TYK2

1 |

Pacritinib inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

21604762

Pacritinib affects JAK1

| 1

Pacritinib inhibits JAK1. 1 / 1

| 1

---

➶

reach

"Pacritinib did not inhibit JAK1 (82% control at 100 nM)."

27574472

PPG affects TRIM25

| 1

PPG inhibits TRIM25. 1 / 1

| 1

---

➶

reach

"Mutation of the PPG motif to PLG (P214L) abolished the EF-P requirement for atpD and, conversely, lengthening the PPG of atpA to PPPG (R279P) induced strong EF-P dependence."

25144653

PPG affects NLRP3

| 1

PPG inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Functionally, modification of PPG to impart lysozyme resistance results in not only evasion of detection by PRRs, but also limiting of host production of important inflammatory mediators such as interleukin (IL)-1beta via the Nod like receptor (NLR) family pyrin-domain-containing 3 (NLRP3) inflammasome (see sidebar) and interferon-beta."

25002085

PPG affects IFNB1

| 1

PPG inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Functionally, modification of PPG to impart lysozyme resistance results in not only evasion of detection by PRRs, but also limiting of host production of important inflammatory mediators such as interleukin (IL)-1beta via the Nod like receptor (NLR) family pyrin-domain-containing 3 (NLRP3) inflammasome (see sidebar) and interferon-beta."

25002085

PPG affects FOS

| 1

PPG inhibits FOS. 1 / 1

| 1

---

➶

reach

"Furthermore, PPG pretreatment attenuated the induction of c-Fos in spinal laminae I-II following injection of 5% formalin."

18248901

PP2 affects MAPK14

1 |

PP2 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

PLX-4720 affects RIPK1

| 1

PLX-4720 inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"Moreover, IkappaBalpha silencing diminished killing by PLX4720 in Mel-CV with or without RIP1 silenced 13."

29880840

PI-103 affects RIPK1

| 1

PI-103 inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"Similarly, genetic knockdown of RIP1 did not afford protection from cell death in the cells treated with PI-103."

26814436

PH-797804 affects MAPK14

1 |

PH-797804 inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

PGL-1 affects TICAM1

| 1

PGL-1 inhibits TICAM1. 1 / 1

| 1

---

➶

reach

"Exposing BMDMs or THP-1 cells to 25microM PGL-1 for> 6h led to similar effects, although maximal downregulation of TRIF by PGL-1 reached a plateau at 50%."

29403489

PF-956980 affects JAK1

1 |

PF-956980 inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

27983835

PF-03715455 affects MAPK14

1 |

PF-03715455 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

21888439

PF affects CASP1

| 1

PF inhibits CASP1. 1 / 1

| 1

---

➶

reach

"In addition, PF significantly suppressed PMACI induced histamine release and caspase-1 activation in HMC-1 cells."

30076630

PEFICITINIB affects TYK2

1 |

PEFICITINIB inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

26351728

PEFICITINIB affects JAK1

1 |

PEFICITINIB inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

26351728

PEFICITINIB HYDROBROMIDE affects TYK2

1 |

PEFICITINIB HYDROBROMIDE inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

26351728

PEFICITINIB HYDROBROMIDE affects JAK1

1 |

PEFICITINIB HYDROBROMIDE inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

26351728

PD173955 affects MAPK14

1 |

PD173955 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

PD-153035 affects IKBKB

| 1

PD-153035 inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Our data demonstrated that PD 153035 administration for 14 days prevents the activation of IKKbeta and JNK in liver, muscle, and WAT, which may be a consequence of the reduction in inflammation in WAT and in the circulating levels of FFAs, TNF-alpha, and IL-6."

19696185

PD-0166285 affects MAPK8

1 |

PD-0166285 inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

PD-0166285 affects MAPK14

1 |

PD-0166285 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

PD 0325901 affects MAPK8

| 1

PD 0325901 inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"PD0325901 blocks phosphorylation of ERK1/2, the activator kinase immediately downstream of MEK, without blocking phosphorylation of p38, JNK, or ERK5.( - ) PD0325901 has improved oral bioavailability and aqueous solubility over its parent compound, CI-1040.( - ) All procedures were approved by the Committee on Animal Research at the University of California San Francisco."

21472778

PD 0325901 affects FOS

| 1

PD 0325901 inhibits FOS. 1 / 1

| 1

---

➶

reach

"Not surprising, c-fos expression was dramatically decreased when NIH3T3 cells were treated with PD0325901, while treating the cells with LY294002 had little effect on c-fos expression (XREF_FIG)."

23948603

PCID:5359476 affects IKBKB

| 1

PCID:5359476 inhibits IKBKB. 1 / 1

| 1

---

➶

sparser

"Sulfasalazine (SSZ), an anti-inflammatory and immunosuppressive agent, inhibits IKKα and IKKβ thereby blocking NFkB activation ( xref , xref )."

19796605

PCID:5359476 affects CHUK

| 1

PCID:5359476 inhibits CHUK. 1 / 1

| 1

---

➶

sparser

"Sulfasalazine (SSZ), an anti-inflammatory and immunosuppressive agent, inhibits IKKα and IKKβ thereby blocking NFkB activation ( xref , xref )."

19796605

PCID:5281051 affects IFIH1

| 1

PCID:5281051 inhibits IFIH1. 1 / 1

| 1

---

➶

sparser

"Hypericin, which has hydroxyanthraquinone-like moieties, can inhibit NS3 helicase [ xref ]."

30782173

PCID:5034 affects TRAF3

| 1

PCID:5034 inhibits TRAF3. 1 / 1

| 1

---

➶

sparser

"The two tyrphostin molecules AG1478 (IC 100 80 μM) and 9 (IC 100 80 μM) are effective against mammalian tyrosine kinases ( xref ), whereas GW 5074 (IC 100 60 μM) inhibits the cRaf-1 kinase ( xref ), which functions downstream of the Ras GTPase."

19429755

PB1-F2 affects IFNB1

| 1

PB1-F2 inhibits IFNB1. 1 / 1

| 1

---

➶

sparser

"Because the colocalization of PB1-F2 HK97 and the stabilized K→R variant was not observed ( xref ), it is surprising that HK97-derived PB1-F2 inhibition of the IFN-β promoter is stronger than PR8-derived PB1-F2 inhibition."

25866881

PACRITINIB affects TYK2

1 |

PACRITINIB inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

21604762

P54 affects NFKB1

1 |

P54 inhibits NFKB1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

OSI-632 affects MAPK14

1 |

OSI-632 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

O-phospho-L-threonine affects RELA

| 1

O-phospho-L-threonine inhibits RELA. 1 / 1

| 1

---

➶

reach

"Phosphothreonine lyase promotes p65 degradation in a MAPK-MSK1-dependent manner."

30396897

O-(3-O-D-galactosyl-N-acetyl-beta-D-galactosaminyl)-L-serine affects JUN

| 1

O-(3-O-D-galactosyl-N-acetyl-beta-D-galactosaminyl)-L-serine inhibits JUN. 1 / 1

| 1

---

➶

reach

"In contrast, differentiation of SV-40 large T antigen transformed 3T3T cells (CSV3-1) does not repress growth factor responsiveness nor c-jun or junB inducibility even though CSV3-1 cells can differentiate into adipocytes."

8922393

O-(3-O-D-galactosyl-N-acetyl-beta-D-galactosaminyl)-L-serine affects JAK1

| 1

O-(3-O-D-galactosyl-N-acetyl-beta-D-galactosaminyl)-L-serine inhibits JAK1. 1 / 1

| 1

---

➶

reach

"It is likely that viral large T antigen employs cellular inhibitor (s), such as SOCS (suppressor of cytokine signals), to inhibit JAK1 (Ref."

10217832

Nutlin-3 affects RELA

| 1

Nutlin-3 inhibits RELA. 1 / 1

| 1

---

➶

reach

"Furthermore, the p53 activator Nutlin-3 was found to reverse the down-regulation of p53 and p65 caused by AZD7762, which indicated this pathway was p53 dependent."

25478729

Nonylphenol affects IRF7

| 1

Nonylphenol inhibits IRF7. 1 / 1

| 1

---

➶

reach

"Our data show that NP may inhibit type I IFN responses of pDCs by downregulating IRF-7 and ERK activity and lead to decreased anti-viral activity."

24039973

Nonylphenol affects IFNB1

| 1

Nonylphenol inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"In addition, NP also significantly inhibited IFN-beta production of pDCs in response to CpG plus IL-3 stimulation (XREF_FIG)."

24039973

NSC-87877 affects STING1

| 1

NSC-87877 inhibits STING1. 1 / 1

| 1

---

➶

reach

"Furthermore, NSC-87877 also significantly reversed the inhibition function of STING on poly (dA : dT)-induced phosphorylation of JAK1 (XREF_FIG)."

25947293

NS-5 affects STAT1

| 1

NS-5 inhibits STAT1. 1 / 1

| 1

---

➶

eidos

"NS2B , NS4A and NS5 have all been shown to prevent STAT1 activation to various degrees ."

27367734

NS-5 affects DDX58

| 1

NS-5 inhibits DDX58. 1 / 1

| 1

---

➶

eidos

"For example , DV NS3 , NS4A , and NS5 inhibit the RIG-I pathway activation by the methylation of the DV RNA ( DV NS5 ) or by blocking the RIG-I / MAVS interaction ( DV NS4A ) ( Chazal et al ., 2018 ) ."

32411105

NS-398 affects NFKB1

| 1

NS-398 inhibits NFKB1. 1 / 1

| 1

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➶

reach

"COX-2, and NF-kappaB p50 and p65 were down-regulated by NS398 in a concentration and time responsive manner (data not shown)."

14532848

NS-398 affects JUN

| 1

NS-398 inhibits JUN. 1 / 1

| 1

---

➶

reach

"However, in the present study we found that both piroxicam, a general COX inhibitor, and NS-398, a COX-2 selective inhibitor, effectively suppressed the activation of transcription factor activator protein 1 (AP-1) induced by ultraviolet B (UVB) or 12-O-tetradecanoylphorbol-13-acetate in mouse epidermal JB6 cells."

12433932

NOX-700 affects NFKB1

1 |

NOX-700 inhibits NFKB1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

NOTHOSPONDIN affects JUN

1 |

NOTHOSPONDIN inhibits JUN. 1 / 1

1 |

---

➶

tas

No evidence text available

24831826

NILOTINIB HYDROCHLORIDE MONOHYDRATE affects MAPK8

1 |

NILOTINIB HYDROCHLORIDE MONOHYDRATE inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

NG25 affects MAPK8

1 |

NG25 inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

NG25 affects MAPK14

1 |

NG25 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

NG25 affects MAP3K7

1 |

NG25 inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

NF-kappaB Decoy affects NFKB1

1 |

NF-kappaB Decoy inhibits NFKB1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

NADPH affects STAT1

| 1

NADPH inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Activation of STAT1 activation was dependent on ROS generation through NOX3 NADPH oxidase, knockdown of which by siRNA reduced STAT1 activation."

21776018

NADPH affects JAK1

| 1

NADPH inhibits JAK1. 1 / 1

| 1

---

➶

reach

"An NADPH oxidase inhibitor diphenyleneiodonium (DPI) suppressed H. pylori induced activation of Jak1 and Stat3 in AGS cells, suggesting that ROS may activate Jak1 and Stat3, determined by phosphorylation of Jak1 and Stat3."

25837197

NADPH affects CASP1

| 1

NADPH inhibits CASP1. 1 / 1

| 1

---

➶

reach

"In support of this, caspase-1 activation by hyperosmotic stress was inhibited by the mitochondrial ROS inhibitor MitoTEMPO, but not by the NADPH oxidase inhibitor apocynin or the xanthine oxidase inhibitor allopurinol (XREF_FIG)."

25959047

NAD(+) affects RELA

| 1

NAD(+) inhibits RELA. 1 / 1

| 1

---

➶

reach

"Furthermore, AMPK can activate Sirtuin 1 (SIRT1), an NAD dependent deacetylase that has been shown to deacetylate and thus inactivate p65, a subunit of NFkappaB, in HEK 293T cells expressing p65 70."

26045163

NAD(+) affects NLRP3

| 1

NAD(+) inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"In line with the reduction of ASC specks, paclitaxel augmented NLRP3 inflammasome activation was also inhibited by resveratrol, NAD +, or MEC-17 siRNA knockdown."

30761140

NAD(+) affects NFKB1

| 1

NAD(+) inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"As discussed above, the increased NAD + could inhibit proinflammatory NF-KB signal pathway, which was suppressed (IGHA2, IGHA1, CPNE3, IGHG1, IGHM, tr | A2N011 | A2N011_HUMAN) in AMS-individuals in our present study."

29352170

NAC affects NFKBIA

| 1

NAC inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"As shown in XREF_FIG, NAC pre-treatment blocked TQ induced down-regulation of NFkappaB targets; IkappaBalpha, Bcl-2 and Survivin confirming the mode of action of TQ being ROS release in ABC cells."

23555990

NAC affects JAK1

| 1

NAC inhibits JAK1. 1 / 1

| 1

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➶

reach

"XREF_FIG showed that NAC or DPI administration could efficiently block the enhancement effect of NOX4 on IL-6 expression, as well as JAK1 and STAT3 activation in A549 cells, respectively."

25504436

NAC affects IRF3

| 1

NAC inhibits IRF3. 1 / 1

| 1

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➶

reach

"Although NAC has been shown to inhibit the activation of both NF-kappaB and IRF3, we have not seen increased activation of NF-kappaB or IRF3, or increased production of the IRF3 dependent cytokine CCL5 and RANTES in TRAPS."

21282379

NAC affects DDX58

| 1

NAC inhibits DDX58. 1 / 1

| 1

---

➶

reach

"NAC, in a dose related manner, was able to restore the antiviral response by preventing suppression of oxidant sensitive RIG-1."

25125976

N-tosyl-L-phenylalanyl chloromethyl ketone affects NFKBIA

1 |

N-tosyl-L-phenylalanyl chloromethyl ketone inhibits NFKBIA. 1 / 1

1 |

---

➶

ctd

No evidence text available

15687330

N-tosyl-L-phenylalanyl chloromethyl ketone affects IRF3

| 1

N-tosyl-L-phenylalanyl chloromethyl ketone inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Staurosporine and TPCK but not TLCK blocked the activation of IRF-3 induced by LPS or poly (I : C)."

12062447

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide affects TBK1

1 |

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide affects MAPK8

1 |

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide affects IKBKE

1 |

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide affects IKBKB

1 |

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide inhibits IKBKB. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide affects CHUK

1 |

N-tert-butyl-3-[[5-methyl-2-[4-[2-(1-pyrrolidinyl)ethoxy]anilino]-4-pyrimidinyl]amino]benzenesulfonamide inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

N-nitrosodiethylamine affects STING1

| 1

N-nitrosodiethylamine inhibits STING1. 1 / 1

| 1

---

➶

reach

"DEN replication was reduced with overexpression of MPYS but not with MITA, while DEN replication was enhanced by MPYS knockdown, indicating an antiviral role of MITA and MPYS against DEN infection."

22761576

N-nitrosodiethylamine affects STAT1

| 1

N-nitrosodiethylamine inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Significant suppression of STAT1 phosphorylation at Tyr701 was responsible for Type I IFN antagonism of JEV NS5 proteins, in agreement with prior studies: WNV and TBEV NS5 proteins suppressing tyrosine phosphorylation of STAT1 and DEN NS5 protein suppressing tyrosine phosphorylation of STAT2, blocking formation of STAT1/STAT1 homo-or heterodimers in Type I IFN-induced JAK/STAT signaling pathway [8, [10] [11] [12] [13] 35] ."

24166946

N-nitrosodiethylamine affects MAPK8

| 1

N-nitrosodiethylamine inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"Hui et al. detected high levels of p-Jnk1 in human HCC lesions and found that the incidence of DEN and phenobarbital induced HCC was significantly reduced in Jnk1 -/- but not in Jnk2 -/- mice."

22340589

N-nitrosodiethylamine affects IRF3

| 1

N-nitrosodiethylamine inhibits IRF3. 1 / 1

| 1

---

➶

reach

"We found that activation of interferon regulatory factor 3 (IRF3) triggered by viral infection and by foreign DNA and RNA stimulation was blocked by DEN encoded NS2B3 through a protease dependent mechanism."

22761576

N-nitrosodiethylamine affects IKBKB

| 1

N-nitrosodiethylamine inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Deletion of Met, Egfr, ctnnb1 or Ikkbeta in hepatocytes surprisingly enhanced HCC development in mice treated with a chemical carcinogen diethylnitrosamine, DEN."

27974211

N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]methanesulfonamide affects TYK2

1 |

N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]methanesulfonamide inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

N-methyl-D-aspartic acid affects TRIM25

| 1

N-methyl-D-aspartic acid inhibits TRIM25. 1 / 1

| 1

---

➶

reach

"NMDA antagonist NPC-17742 blocked potentiation of EFP slopes in both the medial perforant path and hilus pathways."

7874234

N-methyl-D-aspartic acid affects NFKBIA

| 1

N-methyl-D-aspartic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"NMDA and non NMDA receptor stimulated IkappaB-alpha degradation : differential effects of the caspase-3 inhibitor DEVD.CHO, ethanol and free radical scavenger OPC-14117."

10719066

N-methyl-D-aspartic acid affects NFKB1

| 1

N-methyl-D-aspartic acid inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"In the striatum, administration of a free radical scavenger, prior to a toxic infusion of quinolinic acid, an NMDA agonist, attenuates the increase in activation of NFKB, the decrease in IKB degrada- tion, the augmentation in c-MYC and ~ 53 and the intemucleosomal DNA fragmentation (Nakai et al., 1999)."

11545005

N-methyl-D-aspartic acid affects JUN

| 1

N-methyl-D-aspartic acid inhibits JUN. 1 / 1

| 1

---

➶

reach

"Blockade by N-methyl-D-aspartate of elevation of activator protein-1 binding after stress in rat adrenal gland."

12271465

N-methyl-4-phenylpyridinium affects RELA

1 |

N-methyl-4-phenylpyridinium inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

25232110

N-hexadecanoylsphingosine affects NFKBIA

| 1

N-hexadecanoylsphingosine inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Addition of exogenous PC-PLC, SMase, or C16-ceramide to cell homogenates of U937 cells induced degradation of IKBa [85]."

8664339

N-formyl-L-methionyl-L-leucyl-L-phenylalanine affects NFKBIA

| 1

N-formyl-L-methionyl-L-leucyl-L-phenylalanine inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"This speculation is supported by i) our results showing that intestinal epithelial cells pre-treated with butyrate were more sensitive than un treated cells to fMLP induces IkappaB-alpha degradation and by ii) publications demonstrating that in vivo perfusion of fMLP induces PepT1 mediated colonic inflammation in a short bowel model where PepT1 is expressed in colonic epithelial cells XREF_BIBR, XREF_BIBR."

18575574

N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide affects MAPK14

1 |

N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide affects MAPK14

1 |

N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide affects MAPK14

1 |

N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide affects MAPK14

1 |

N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

N-cyclopropyl-3-\{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydropyrazolo[3,4-b]pyridin-4-yl]amino\}-4-methylbenzamide affects MAPK14

1 |

N-cyclopropyl-3-\{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydropyrazolo[3,4-b]pyridin-4-yl]amino\}-4-methylbenzamide inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

19574047

N-cyclopropyl-3-[3-[[cyclopropyl(oxo)methyl]amino]-1H-indazol-6-yl]benzamide affects RIPK1

1 |

N-cyclopropyl-3-[3-[[cyclopropyl(oxo)methyl]amino]-1H-indazol-6-yl]benzamide inhibits RIPK1. 1 / 1

1 |

---

➶

tas

No evidence text available

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects TRAF3

| 1

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits TRAF3. 1 / 1

| 1

---

➶

medscan

"It was recently demonstrated that TRAF3 degradation in A549 cells is mediated by the E3 ligase, Triad3A, and is prevented by the proteasome inhibitors Lactacystin and MG132 ( )."

23303668

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects RIPK1

| 1

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"To this end, the effect of PCTAIRE1 on RIPK1 protein stability was examined by immunoblotting of cell lysates treated with the proteasome inhibitor MG132, which reduced PCTAIRE1-knockdown-mediated RIPK1 degradation (XREF_FIG)."

25790448

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects JUN

| 1

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits JUN. 1 / 1

| 1

---

➶

reach

"Either cycloheximide (CHX) or the cysteine protease inhibitor, MG132, restored the responsiveness of p39 to growth factors in nutrient starved cells."

12217078

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects ITCH

| 1

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Further, MG132 a proteasome inhibitor blocked Itch mediated degradation of Tak1 in a similar experiment (XREF_FIG)."

22057290

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects IFNB1

| 1

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"In fact, the MG-132 proteasome inhibitor was able to restore IFN-beta promoter activation in cells expressing NSs, demonstrating the existence of an evasion mechanism based on inhibition of the RIG-I sensor."

23552410

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects FOS

| 1

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits FOS. 1 / 1

| 1

---

➶

reach

"Although MG132 prevention of c-Fos and/or c-Jun degradation might account for AP-1 activation, the rapid JNK activation by MG132 is another alternative pathway [15]."

12208513

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects DDX58

| 1

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits DDX58. 1 / 1

| 1

---

➶

reach

"The results indicated that MG132 inhibited G3BP1 mediated upregulation of RIG-I and G3BP1 stabilized RIG-I via the ubiquitin-proteasome pathway."

31827077

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects CASP1

| 1

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal inhibits CASP1. 1 / 1

| 1

---

➶

reach

"However, the proteasome inhibitor MG132 inhibited LeTx induced pyroptosis and caspase-1 autoproteolysis altogether (data not shown), thus hampering investigation of the potential role of the proteasome in degrading inflammasome activated caspase-1."

24492532

N-acetylsphingosine affects FOS

| 1

N-acetylsphingosine inhibits FOS. 1 / 1

| 1

---

➶

reach

"Thus, PACAP increased the proportion of c-Fos and Jun D while C2-ceramide increased c-Jun and reduced c-Fos in AP-1 complexes."

17026529

N-acetyl-beta-neuraminic acid affects CASP1

| 1

N-acetyl-beta-neuraminic acid inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Catechins and Sialic Acid Attenuate Helicobacter pylori Triggered Epithelial Caspase-1 Activity and Eradicate Helicobacter pylori Infection."

23653660

N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-D-glucosaminyl group affects NFKBIA

| 1

N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-D-glucosaminyl group inhibits NFKBIA. 1 / 1

| 1

---

➶

sparser

"Moreover, calcitriol or BMP2 could upregulate the mRNA levels of IκBα, which was inhibited by LDN ( xref )."

28370465

N-acetyl-L-cysteine affects STAT1

| 1

N-acetyl-L-cysteine inhibits STAT1. 1 / 1

| 1

---

➶

medscan

"Pretreatment with Ginkgo biloba extract or N-acetylcysteine inhibited high-glucose-induced reactive oxygen species, interleukin-6 production, STAT1/3 activation, ICAM-1 expression, and endothelial adhesiveness to monocytes."

22553973

N-acetyl-L-cysteine affects ITCH

| 1

N-acetyl-L-cysteine inhibits ITCH. 1 / 1

| 1

---

➶

reach

"The reactive oxygen species scavengers N-acetylcysteine (NAC; 204 mg/kg i.p.; 86%) or superoxide dismutase (SOD; 10 mg/kg i.p.; 83%) also inhibited itch."

23271050

N-acetyl-L-cysteine affects CHUK

1 |

N-acetyl-L-cysteine inhibits CHUK. 1 / 1

1 |

---

➶

ctd

No evidence text available

17395010

N-acetyl-L-cysteinate affects TRAF6

| 1

N-acetyl-L-cysteinate inhibits TRAF6. 1 / 1

| 1

---

➶

reach

"Moreover, N-acetyl-L-cysteine, an ROS scavenger, suppressed the TRAF6 accumulation induced by oxygen-glucose deprivation via suppression of ROS bursts."

32253651

N-acetyl-L-cysteinate affects IKBKB

| 1

N-acetyl-L-cysteinate inhibits IKBKB. 1 / 1

| 1

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➶

reach

"Blockade of IKkB and NF-kB activation by N-acetyl-L-cysteine XREF_BIBR, XREF_BIBR largely abolished IL6 activation of NF-kB in GNAI1; 3DKO MEFs (XREF_SUPPLEMENTARY)."

30836096

N-acetyl-L-cysteinate affects CASP1

| 1

N-acetyl-L-cysteinate inhibits CASP1. 1 / 1

| 1

---

➶

reach

"The PS-NH (2)-mediated proinflammatory macrophage activation could be antagonized by the radical scavenger N-acetyl-L-cysteine, which prevented mitochondrial damage, caspase-1 activation, and the subsequent release of IL-1beta."

22111911

N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide affects MAPK14

1 |

N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide affects IKBKB

1 |

N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide inhibits IKBKB. 1 / 1

1 |

---

➶

tas

No evidence text available

N-[4-CHLORO-3-(PYRIDIN-3-YLOXYMETHYL)-PHENYL]-3-FLUORO- affects MAPK14

1 |

N-[4-CHLORO-3-(PYRIDIN-3-YLOXYMETHYL)-PHENYL]-3-FLUORO- inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide affects TANK

| 1

N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide inhibits TANK. 1 / 1

| 1

---

➶

reach

"TANK derived signals may not only travel via TBK1 and IKKepsilon, as ERK1/2 phosphorylation in A271 and U373 cells is affected by downregulation of TANK but not by BX795."

24217713

N-[3-[[5-bromo-4-[2-(1H-imidazol-5-yl)ethylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide affects TYK2

1 |

N-[3-[[5-bromo-4-[2-(1H-imidazol-5-yl)ethylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

N-[3-(aminomethyl)benzyl]acetamidine affects IKBKB

| 1

N-[3-(aminomethyl)benzyl]acetamidine inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Our results show that 1400W reduced the S nitrosylated JNK, Bcl-2, and Ikkbeta and relieved their downstream signaling molecular functions."

31783459

N-[2-methyl-5-[[[3-(4-methyl-1-imidazolyl)-5-(trifluoromethyl)phenyl]-oxomethyl]amino]phenyl]-5-isoxazolecarboxamide affects MAPK14

1 |

N-[2-methyl-5-[[[3-(4-methyl-1-imidazolyl)-5-(trifluoromethyl)phenyl]-oxomethyl]amino]phenyl]-5-isoxazolecarboxamide inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamide affects MAPK14

1 |

N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamide inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide affects RELA

| 1

N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide inhibits RELA. 1 / 1

| 1

---

➶

reach

"In our study, however, H-8 did not inhibited levels of MUC2 protein and NF-kappaB p65 protein both in the presence and absence of DCA in SEG-1 cells."

19014523

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide affects RELA

| 1

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide inhibits RELA. 1 / 1

| 1

---

➶

sparser

"H-89 inhibited constitutive p-p65 (Ser 276) at 1 hour of treatment and more significantly at 6 hours, persisting for 24 hours ( xref , left panels)."

19789307

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide affects CASP1

| 1

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide inhibits CASP1. 1 / 1

| 1

---

➶

reach

"This was the case, with the CGS21680 induced up-regulation in LPS and ATP induced active caspase-1 being reduced by SQ22536 and H-89 (XREF_FIG)."

24352507

N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE affects MAPK8

1 |

N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE inhibits MAPK8. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

N-(3-carboxypropanoyl)-N-hydroxyputrescine affects NLRP3

| 1

N-(3-carboxypropanoyl)-N-hydroxyputrescine inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"We decided to explore the effects of either a heat shock (HS) or the deficiency in heat shock protein (HSP) 70, previously shown to respectively inhibit or increase NLRP3 inflammasome activation in macrophages."

32385145

N-(3-carboxypropanoyl)-N-hydroxyputrescine affects NFKBIA

| 1

N-(3-carboxypropanoyl)-N-hydroxyputrescine inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"This could be related to the anti-inflammatory effects of HSPs within a heat shock response [XREF_BIBR, XREF_BIBR], as HSPs are activators of anti-inflammatory regulatory T cells [XREF_BIBR] and HSP induction most probably blocks the NF-kB activation by stabilizing IkappaBalpha [XREF_BIBR]."

26402906

N-(3-carboxypropanoyl)-N-hydroxyputrescine affects NFKB1

| 1

N-(3-carboxypropanoyl)-N-hydroxyputrescine inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"In the present study, we assumed that sesquiterpene lactones such as costunolide (1) and dehydrocostus lactone (2) combine with SH groups of proteins, thereby inducing HSP 72, which in turn suppressed NF-KB activation followed by iNOS induction."

10834299

N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-n-methyl-7h-pyrrolo[2,3-d]pyrimidin-4-amine affects JAK1

1 |

N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-n-methyl-7h-pyrrolo[2,3-d]pyrimidin-4-amine inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22591402

N,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide affects MAPK14

1 |

N,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

N(omega),N(omega)-dimethyl-L-arginine affects RELA

| 1

N(omega),N(omega)-dimethyl-L-arginine inhibits RELA. 1 / 1

| 1

---

➶

reach

"Disruption of asymmetric dimethylarginine induced RelA and P65 association with actin in endothelial cells."

23296075

Myricetin affects JAK1

1 |

Myricetin inhibits JAK1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

18995957

Met-Phe affects MYD88

| 1

Met-Phe inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Moreover, MF reduced neuroinflammation, inhibited gliosis, and attenuated the activation of P2X7 receptor, TLR4 and MyD88, NLRP3, and NF-kappaB."

31766248

Met-Met affects STING1

| 1

Met-Met inhibits STING1. 1 / 1

| 1

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➶

reach

"Using this infectivity assay, we found that wild-type Mm had reduced infectivity in Sting deficient animals (XREF_FIG F), similar to PGL deficient bacteria in wild-type animals and wild-type bacteria in Ccr2 deficient animals."

28844797

Met-His affects CASP1

| 1

Met-His inhibits CASP1. 1 / 1

| 1

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➶

reach

"In addition, MH has been shown to attenuate increases in caspase-1 and 3 expression in vivo (Chen et al., 2000; Festoff et al., 2006)."

28616020

Met-Asp affects TYK2

| 1

Met-Asp inhibits TYK2. 1 / 1

| 1

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➶

reach

"In addition, the MD simulation study supports that E738 is a dual inhibitor of Tyk2 and Src, since it can form several hydrogen bonds associated with high pair-interaction energies to both proteins in the simulations."

23206899

Meriolin 2 affects MAP3K7

1 |

Meriolin 2 inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

Meriolin 2 affects IKBKB

1 |

Meriolin 2 inhibits IKBKB. 1 / 1

1 |

---

➶

tas

No evidence text available

Meriolin 2 affects CHUK

1 |

Meriolin 2 inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

Matrine affects JAK1

| 1

Matrine inhibits JAK1. 1 / 1

| 1

---

➶

reach

"Whether matrine can inhibit activation of the JAK1 and STAT3 signaling pathway in NSCLC is still unknown."

28656237

Manumycin A affects CHUK

| 1

Manumycin A inhibits CHUK. 1 / 1

| 1

---

➶

medscan

"The peptidoglycan-mediated increase in the activities of IKKalpha/beta and kappaB-luciferase were also inhibited by the Ras dominant negative mutant (RasN17), manumycin A, GW 5074, and PD 098059."

15007072

MPLA affects MYD88

| 1

MPLA inhibits MYD88. 1 / 1

| 1

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➶

sparser

"Given that MPLA inhibited both the MyD88 and TRIF-dependent pathways induced by LPS, we hypothesized that the effect of MPLA was exerted at the level of the TLR4 receptor, proximal to the separation of these distinct signaling pathways."

25540284

MOMELOTINIB DIHYDROCHLORIDE affects CHUK

1 |

MOMELOTINIB DIHYDROCHLORIDE inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

MLN0415 affects IKBKB

1 |

MLN0415 inhibits IKBKB. 1 / 1

1 |

---

➶

drugbank

No evidence text available

ML-7 affects RELA

1 |

ML-7 inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

15526279

ML-7 affects NFKBIA

1 |

ML-7 inhibits NFKBIA. 1 / 1

1 |

---

➶

ctd

No evidence text available

15526279

MK-2206 affects IFNB1

| 1

MK-2206 inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"XREF_FIG show that the NF-kappaB activation and the IFN-beta production induced by gD -/- virions was almost abolished by MK2206."

25375272

MC1568 affects FOS

| 1

MC1568 inhibits FOS. 1 / 1

| 1

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➶

reach

"Together, these data show that MC1568 inactivates neuronal CREB and c-fos in ischemic brain."

27103167

Lys-Thr affects MAPK8

| 1

Lys-Thr inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"Jun D-Y, Teramoto H, Giam C-Z, Chun RF, Gutkind JS, Jeang K-T : A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor a. J Biol Chem 1997, 272:25 ti16-25823."

9561845

Lys-Pro affects NLRP3

| 1

Lys-Pro inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"KP inhibits NLRP3 inflammasome activation, leading to reduced NLRP3 protein expression and deactivation of the NLRP3 inflammasome in order to promote macroautophagy and autophagy in microglia."

31572524

Lys-Phe affects RELA

| 1

Lys-Phe inhibits RELA. 1 / 1

| 1

---

➶

reach

"KF reduced NF-kappaB (p65 and p50) and AP-1 (c-Jun and c-Fos) levels in the nucleus and their transcriptional activity."

25922567

Lys-Phe affects NFKB1

| 1

Lys-Phe inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"KF reduced NF-kappaB (p65 and p50) and AP-1 (c-Jun and c-Fos) levels in the nucleus and their transcriptional activity."

25922567

Lys-Phe affects MYD88

| 1

Lys-Phe inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Since LPS induced translocation of c-Jun and c-Fos (XREF_FIG left panel) and MyD88 dependent AP-1 activation were reduced by KF, the inhibitory effect of KF on upstream signaling for AP-1 activation was examined."

25922567

Lys-Phe affects FOS

| 1

Lys-Phe inhibits FOS. 1 / 1

| 1

---

➶

reach

"KF reduced NF-kappaB (p65 and p50) and AP-1 (c-Jun and c-Fos) levels in the nucleus and their transcriptional activity."

25922567

Leu-Val-Ser affects RELA

| 1

Leu-Val-Ser inhibits mutated RELA. 1 / 1

| 1

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➶

reach

"The double deletion of relA and spoT in F. tularensis LVS resulted in complete disappearance of (p) ppGpp production and increased the robustness of the relA mutant phenotypes."

21687801

Leu-Val-Ser affects NFKBIA

| 1

Leu-Val-Ser inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"LVS and LVSDeltaripA each induced degradation of IkappaBalpha 30-60 min postinfection and phosphorylation of p65 15-30 min postinfection (XREF_FIG)."

20921527

Leu-Val-Ser affects CASP1

| 1

Leu-Val-Ser inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Taken together, these data suggest that F. tularensis LVS expression of mviN was required to limit caspase-1 activation and subsequent cytotoxicity and secretion of IL-1beta and IL-18; and although the mviN mutant was able to replicate within unprimed Mphi in vitro, attenuation of infection by the mviN mutant in vivo was most probably due to increased death of F. tularensis infected Mphi and increased proinflammatory cytokine production."

20679532

Leu-Val affects STAT1

| 1

Leu-Val inhibits STAT1. 1 / 1

| 1

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➶

reach

"STAT1 or OAS1 was not induced by LV siRNA; however, HV saline led to a time dependent slight increase in gene expression."

21749298

Leu-Tyr affects IFNB1

| 1

Leu-Tyr inhibits IFNB1. 1 / 1

| 1

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➶

reach

"They confirm that LY inhibited Ad-IRF3-upregulated genes (IFNbeta, IFIT1, IL-1ra and IL-10) while increasing Ad-IRF3-inhibited genes (IL-8, CXCL1, TNFalpha, and IL-1beta)."

22208359

Leu-Ile affects NFKB1

| 1

Leu-Ile inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Maran A., Maitra R. K., Kumar A., Dong B., Xiao W., Li G., Williams B. R. G., Torrence P. F. and Silverman R. H. (1994) Blockage of NF-KB signaling by selective 877 ablation of an mRNA target by 2-5A antisense chimeras."

7584622

Leu-Ile affects CASP1

| 1

Leu-Ile inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Chung, W.M., Frey, A.S., Menon, A.S., Li, X.J., Stieg, P.E., Yuan, J., Penney, J.B., Young, A.B., Cha, J.H. and Friedlander, R.M. (1999) Inhibition of Caspase-1 slows disease progression in a mouse model of Huntington 's disease."

11545027

Leu-Cys affects TANK

| 1

Leu-Cys inhibits TANK. 1 / 1

| 1

---

➶

reach

"The surface electric reactance is where Z LC is the circuit impedance of a single LC tank, Z d is the impedance of the varactor, L is parallel inductance, and 2g and 2b are the width and height of the unit cell."

| PMC

Leu-Cys affects RELA

| 1

Leu-Cys inhibits RELA. 1 / 1

| 1

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➶

reach

"This analysis showed that both LC n-3 PUFA reduced NF-kappaB p65 to an equivalent extent at 2 h LPS stimulation."

19427777

Leu-Ala affects ITCH

| 1

Leu-Ala inhibits ITCH. 1 / 1

| 1

---

➶

reach

"On the other hand, the L-A and R-C intervention suppressed the peak itch sensation, but the effects did not last for more than a few minutes."

26190177

LY294002 affects MAPK14

1 |

LY294002 inhibits MAPK14. 1 / 1

1 |

---

➶

ctd

No evidence text available

15631803

LY294002 affects IKBKE

| 1

LY294002 inhibits IKBKE. 1 / 1

| 1

---

➶

medscan

"An AKT inhibitor LY294002 effectively suppressed IKK/IκB/NF-κB signaling and PON1 gene expression induced by IL-6."

23791833

LY294002 affects IKBKB

| 1

LY294002 inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Additionally, LY294002, AKT-shRNA and IkappaBalpha-shRNA could decrease the protein content of phospho-IkappaBalpha and phospho-IKKbeta in STC1 overexpressed HeLa and CaSki cells compared with the control cells."

28545028

LY294002 affects FOS

| 1

LY294002 inhibits FOS. 1 / 1

| 1

---

➶

reach

"Meanwhile, nuclear c-Fos was also significantly reduced by LY294002 treatment (p < 0.03)."

18615585

LY294002 affects CHUK

| 1

LY294002 inhibits CHUK. 1 / 1

| 1

---

➶

medscan

"The OPN-mediated increases in IKK alpha/beta, IkappaBalpha and p65 Ser(536) phosphorylation were inhibited by Ly294002, Akt inhibitor and PD98059. 32999999="S536"}"

18996613

LY-2157299 affects MAPK14

1 |

LY-2157299 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

26483198

LSM-36909 affects NFKBIA

| 1

LSM-36909 inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"In the present study, the level of IkappaBalpha was decreased in the liver and AML12 cells treated with AFB1."

30621122

LPS with O-antigen affects TRAF6

| 1

LPS with O-antigen inhibits TRAF6. 1 / 1

| 1

---

➶

reach

"Lipopolysaccharide induced osteoclast formation and osteolysis were significantly inhibited in Traf6 conditional knockout mice."

29273889

LPS with O-antigen affects TRAF3

| 1

LPS with O-antigen inhibits TRAF3. 1 / 1

| 1

---

➶

reach

"Thus, our findings reveal a novel mechanism of endotoxin mediated TRAF3 degradation in KCs."

30579117

LPS with O-antigen affects NLRP3

| 1

LPS with O-antigen inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Lipopolysaccharide from phosphorylcholine (ChoP)-positive bacteria induced NLRP3 and caspase-1 proteins in human alveolar epithelial cells, however antagonism of PAFR prevented NLRP3 activation by ChoP."

30976089

LPS with O-antigen affects NFKBIA

| 1

LPS with O-antigen inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Takeshita et al. showed HCA could inhibit endotoxin induced canonical NF-kappaB activation and IkappaBalpha degradation in human pulmonary artery endothelial cells [XREF_BIBR]."

27001525

LPS with O-antigen affects MAP3K7

| 1

LPS with O-antigen inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"Endotoxin tolerance impairs IL-1 receptor associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63 linked polyubiquitination and assembly of IRAK1, TNF receptor associated factor 6, and IkappaB kinase gamma and increases A20 expression."

21220427

LPS with O-antigen affects IFNB1

| 1

LPS with O-antigen inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"We first pretreated THP-1 macrophages transfected with Ctrl siRNA or GMFG siRNA with 10 ng/ml LPS for 24 h and subsequently challenged them with 100 ng/ml LPS for 24 h. Consistent with published reports describing LPS induced endotoxin tolerance, pretreatment with low-dose LPS nearly completely inhibited TNF-alpha, IL-6, and IFN-beta production after secondary LPS challenge in THP-1 macrophages transfected with Ctrl siRNA (XREF_FIG)."

23677465

LPS with O-antigen affects CASP1

| 1

LPS with O-antigen inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Lipopolysaccharide inhibits long term potentiation in the rat dentate gyrus by activating caspase-1."

10856294

LGD-1550 affects JUN

1 |

LGD-1550 inhibits JUN. 1 / 1

1 |

---

➶

drugbank

No evidence text available

LAX-101 affects CASP1

1 |

LAX-101 inhibits CASP1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

L-prolylglycine affects RELA

| 1

L-prolylglycine inhibits RELA. 1 / 1

| 1

---

➶

reach

"We also found that both p-IkappaB and nuclear p65 in U87MG glioma cells were more suppressed by combined PG and TMZ."

29062841

L-prolylglycine affects NLRP3

| 1

L-prolylglycine inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Proteolysis of the NLRP3 protein was not observed with heat killed Pg and inhibition of ECs protein synthesis with cycloheximide did not abolish the NLRP3 protein degradation induced by Pg infection in ATP pre-treated cells."

24583910

L-prolino group affects MAVS

| 1

L-prolino group inhibits MAVS. 1 / 1

| 1

---

➶

eidos

"This suggests that expression of L pro induces degradation of MAVS , also in FMDV-infected cells ."

32667958

L-prolino group affects DDX58

| 1

L-prolino group inhibits DDX58. 1 / 1

| 1

---

➶

eidos

"L pro and 3C pro both induce RIG-I degradation , whereas the mechanism of how 2B reduces RIG-I protein levels has not been solved yet ( 42 ) ."

27891131

L-kynurenine affects TRAF6

| 1

L-kynurenine inhibits TRAF6. 1 / 1

| 1

---

➶

reach

"The results presented here demonstrate that lipoxins and L-kynurenine induce SOCS2 dependent ubiquitinylation and proteasomal degradation of TRAF6, hindering pro inflammatory cytokine expression by dendritic cells."

22693634

L-glutamine affects ITCH

| 1

L-glutamine inhibits ITCH. 1 / 1

| 1

---

➶

reach

"GPCR Kinase (GRK) -2 Is a Key Negative Regulator of Itch : l-Glutamine Attenuates Itch via a Rapid Induction of GRK2 in an ERK Dependent Way."

29530536

L-glutamine affects IKBKB

| 1

L-glutamine inhibits IKBKB. 1 / 1

| 1

---

➶

medscan

"Here, we report that IκB kinase β (IKKβ) is activated upon glutamine deprivation and is required for cell survival independently of NF-κB transcription."

27585591

L-glutamine affects IFNB1

| 1

L-glutamine inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"The cells were cultivated in six-well plates at density 1 x 10 6 cells and well in RPMI 1640 supplemented with inactivated, 10% fetal bovine serum, 2 mmol/l L-glutamine, 1 mmol/l HEPES, 0.05 mmol/l beta-merpcatoethanol, penicillin, and streptomycin.To eliminate or at least reduce a contaminant activation of IFN-beta production through the Toll like receptor 3 mediated signaling, we used a transfection protocol to deliver poly (I : C) into the cytoplasm of PMBCs, where it can be recognized by MDA5."

20736039

L-glutamic acid affects RELA

| 1

L-glutamic acid inhibits RELA. 1 / 1

| 1

---

➶

reach

"The anti-inflammatory effects of GLT were mediated by the inhibition of transcription factor NF-kappaB as demonstrated by decreased NF-kappaB-DNA binding activity, and the suppression of p65 phosphorylation in LPS stimulated macrophages treated with GLT."

19651243

L-dehydroascorbic acid affects IKBKB

| 1

L-dehydroascorbic acid inhibits IKBKB. 1 / 1

| 1

---

➶

medscan

"ascorbic acid quenches Reactive oxygen species intermediates involved in the activation of NF-kappaB and is oxidized to dehydroascorbic acid, which directly inhibits IKKbeta and IKKalpha enzymatic activity."

15254232

L-cysteine affects PYCARD

| 1

L-cysteine inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Na (+)-dependent L-alanine transport, but not MeAIB transport, was partially inhibited by L-serine and L-cysteine, indicating the participation of system ASC."

11171637

L-cysteine affects NFKB1

| 1

L-cysteine inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Further studies also found that L-cysteine supplementation alone lowered glycemia and caused inhibition of NFkB and Akt and increased IRS-1 activation in the liver but to a lesser extent compared to CDNC supplemented rats."

20306473

L-ascorbic acid affects NFKB1

| 1

L-ascorbic acid inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"For example, vitamin C downmodulates signaling of GM-CSF, a pro inflammatory cytokine, and also inhibits NFkB activation by diverse stimuli XREF_BIBR, XREF_BIBR, suggesting a role for it in anti-inflammatory responses and in immune defense."

20523728

L-ascorbic acid affects JUN

| 1

L-ascorbic acid inhibits JUN. 1 / 1

| 1

---

➶

reach

"Our findings show that vitamin C downregulates the redox sensitive transcription factor AP-1 and decreases one of its transcription targets HPV E6, and stabilizes P53."

11401473

L-ascorbic acid affects CHUK

| 1

L-ascorbic acid inhibits CHUK. 1 / 1

| 1

---

➶

reach

"Moreover, after oxidation to dehydroascorbic acid, vitamin C has been shown to directly inhibit IKKalpha, IKKbeta, and p38 MAPK activity."

23675368

L-arginine affects FOS

| 1

L-arginine inhibits FOS. 1 / 1

| 1

---

➶

reach

"Intraportal L-arginine reduced, while intraportal CCK increased, the number of c-Fos positive cells in the nucleus tractus solitarii in a CHBV dependent manner."

28701913

L-alanyl-L-alanine affects NFKBIA

| 1

L-alanyl-L-alanine inhibits NFKBIA. 1 / 1

| 1

---

➶

sparser

"The IκB kinase (IKK) pathway was examined as another potential regulator of NF-κB. Both AA and THAA inhibited IκBα degradation resulting from LPS stimulation (Fig.  xref C)."

20216944

L-alanyl-L-alanine affects IKBKB

| 1

L-alanyl-L-alanine inhibits IKBKB. 1 / 1

| 1

---

➶

sparser

"In the cell free hotspot kinase assay, the CA, AA and UA inhibited human IKKβ."

25938234

L-alanine affects TRAF6

| 1

L-alanine inhibits TRAF6. 1 / 1

| 1

---

➶

medscan

"When its concentration is near or higher than that of Ubc13, Cys62 of OspI to alanine efficiently inhibits the TRAF6-catalyzed polyubiquitination ( )."

23633953

L-alanine affects IFNAR2

| 1

L-alanine inhibits IFNAR2. 1 / 1

| 1

---

➶

medscan

"Substituting Arg149α2 by alanine reduces the affinity between Interferonα2 and IFNAR2 by two orders of magnitude ( )."

21854986

KW2449 affects TYK2

1 |

KW2449 inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW2449 affects TBK1

1 |

KW2449 inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW2449 affects RIPK1

1 |

KW2449 inhibits RIPK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW2449 affects MAPK8

1 |

KW2449 inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW2449 affects MAP3K7

1 |

KW2449 inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW2449 affects JAK1

1 |

KW2449 inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW2449 affects IKBKE

1 |

KW2449 inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW2449 affects IKBKB

1 |

KW2449 inhibits IKBKB. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW2449 affects CHUK

1 |

KW2449 inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW-2449 affects TYK2

1 |

KW-2449 inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW-2449 affects TBK1

1 |

KW-2449 inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW-2449 affects RIPK1

1 |

KW-2449 inhibits RIPK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW-2449 affects MAPK8

1 |

KW-2449 inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW-2449 affects MAP3K7

1 |

KW-2449 inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW-2449 affects JAK1

1 |

KW-2449 inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW-2449 affects IKBKE

1 |

KW-2449 inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW-2449 affects IKBKB

1 |

KW-2449 inhibits IKBKB. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KW-2449 affects CHUK

1 |

KW-2449 inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

KN-93 affects JUN

| 1

KN-93 inhibits JUN. 1 / 1

| 1

---

➶

reach

"Importantly, KN-93, which inhibits beta-AR stimulated Ncx1 upregulation also prevents the association of c-Jun with the endogenous Ncx1 promoter."

19945464

KC706 affects MAPK14

1 |

KC706 inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

JSH-23 affects RIPK1

| 1

JSH-23 inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"RIPK1 and 3, receptor interacting serine/threonine protein kinases, that play an important role in necroptosis, were decreased by JSH-23."

26546572

JSH-23 affects JUN

| 1

JSH-23 inhibits JUN. 1 / 1

| 1

---

➶

reach

"To further study the functions of transcription factors under hypoxic conditions, JSH-23 and SP600125 were used to block the NF-kappaB and AP-1 and c-Jun pathways."

24002703

JSH-23 affects IFNB1

| 1

JSH-23 inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"To explore whether NF-kappaB is essential for HSV-1-induced early phase IFN-beta production, we pretreated BMMs with different doses of JSH-23, a specific inhibitor of NF-kappaB nuclear translocation and transcriptional activity, 12 before BMMs were subjected to HSV-1 infection for 4 h. ELISA revealed that JSH-23 potently inhibited HSV-1-induced early phase IFN-beta production at the dose as low as 2.5 muM and the inhibitory effect became more significant when the dose increased (XREF_FIG)."

27593482

JNK-In-8 affects IFNB1

| 1

JNK-In-8 inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Interestingly, VX745 also reduced IFN-beta mRNA induction in MSK1/2 knockout BMDMs, while a combination of JNK-In-8 and VX745 suppressed IFN-beta mRNA to a greater extent than either inhibitor alone (XREF_FIG)."

27795299

JNK-IN-8 affects JUN

| 1

JNK-IN-8 inhibits JUN. 1 / 1

| 1

---

➶

reach

"JNK-IN-8 potently inhibits JNK1, 2 and 3 enzymatic activity with IC 50 s of 4.7 nM, 18.7 nM and 1.0 nM respectively and inhibits a c-Jun, a direct phosphorylation substrate of JNK, with an EC 50 of 486 nM in Hela cell."

23438744

Isatoribine affects TLR7

1 |

Isatoribine inhibits TLR7. 1 / 1

1 |

---

➶

drugbank

No evidence text available

16116638

Interferon alfa affects IFNAR1

1 |

Interferon alfa inhibits IFNAR1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

Ins-1-P-Cer(t18:0/2-OH-26:0) affects RELA

| 1

Ins-1-P-Cer(t18:0/2-OH-26:0) inhibits RELA. 1 / 1

| 1

---

➶

reach

"Inhibition of ERK1/2 completely inhibited IPC induced p65 translocation to nucleus at 30 min of reperfusion as compared to IPC group (p < 0.05, n = 5, XREF_FIG)."

20606709

Ins-1-P-Cer(t18:0/2-OH-26:0) affects PYCARD

| 1

Ins-1-P-Cer(t18:0/2-OH-26:0) inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"IPC significantly reduced LDH release in WT (-45%) and in ASC -/- (-33%) hearts."

22848390

Ile-Val affects NLRP3

| 1

Ile-Val inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Iv Inability of Complex I to form ROS impairs NLRP3 activation; whereas excessive mitochondrial ROS enhances NLRP3 inflammasome activity."

31996961

Ile-Thr affects JUN

| 1

Ile-Thr inhibits JUN. 1 / 1

| 1

---

➶

trips

"This effect was correlated with c-Jun activation because inhibition of c-Jun by its dominant negative mutant (TAM67) reversed B(a)P action on cell cycle with the down-regulation of expression of cyclin D1, pRb and E2F1."

18448277

Ile-Leu affects NLRP3

| 1

Ile-Leu inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"This would provide a mechanism for other studies showing that IL‐10 negatively regulates the NLRP3 inflammasome 30.Contribution of the E3 ligase Parkin to NLRP3 regulation has been reported through two different pathways."

31679183

Ile-Leu affects MYD88

| 1

Ile-Leu inhibits MYD88. 1 / 1

| 1

---

➶

reach

"In the present study, we investigated whether the interleukin (IL)-1beta intracellular signal transduction pathway could be blocked by overexpression of dominant negative forms of the IL-1 receptor interacting protein MyD88."

10967106

Ile-Leu affects FOS

| 1

Ile-Leu inhibits FOS. 1 / 1

| 1

---

➶

reach

"Consistent with the post-training radiation enhanced contextual fear memory and fewer c-Fos positive cells in the IL in the current study, activation of the IL reduced conditioned fear and enhanced extinction learning [XREF_BIBR]."

26522840

Ile-Leu affects CASP1

| 1

Ile-Leu inhibits CASP1. 1 / 1

| 1

---

➶

reach

"In nasal mucosa of ovalbumin sensitized BALB/c mice, rosmarinic acid and 30% ethanol extract powder of perilla reduced the number of ear and eye rubs, the levels of IgE and histamine in the serum, inhibited protein and mRNA expression of interleukins (IL)-1beta, IL-6, and tumor necrosis factor-alpha, and inhibited cyclooxygenase-2 protein expression and caspase-1 activity [XREF_BIBR]."

24319488

Ile-Ala affects MAP3K7

| 1

Ile-Ala inhibits MAP3K7. 1 / 1

| 1

---

➶

sparser

"IA inhibited TAK/TAB-mediated IkappaB kinase (IKK) activation loop phosphorylation, resulting in the inhibition of cytokine and lipopolysaccharide-mediated NF-kappaB activation."

17895408

Ile(5)-angiotensin II (1-7) affects MAPK14

| 1

Ile(5)-angiotensin II (1-7) inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"However, Mercure et al. [ ] reported that overexpression of angiotensin-(1-7) in hearts of rats decreases the angiotensin-II-induced phosphorylation of c-Src and p38 kinase, whereas the increase in ERK1/2 phosphorylation was unaffected by the expression of the transgene, thereby suggesting a selective effect of angiotensin-(1-7) on intracellular signaling pathways related to cardiac remodeling."

22319643

Ibudilast affects RELA

| 1

Ibudilast inhibits RELA. 1 / 1

| 1

---

➶

medscan

"AV411 and AV1013 inhibited replication by HIV-1 in microglia and significantly suppressed Tat ± morphine-induced tumor necrosis factor-α and MIF production, the activation of the nuclear factor-kappa B subunit p65, and neuronal death."

24732776

ITX-5061 affects MAPK14

1 |

ITX-5061 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

20663667

ILORASERTIB affects TYK2

1 |

ILORASERTIB inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

ILORASERTIB affects IKBKE

1 |

ILORASERTIB inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

Histone affects PYCARD

| 1

Histone inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Histone deacetylases (HDACs) inhibitor TSA suppressed injury induced ASC in the mouse lens capsular injury model."

25666271

Histone affects IFNB1

| 1

Histone inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"In accordance, ablation of CREM expression or inhibition of histone deacetylases activity eliminates the suppressive effects of IFN-beta on IL-2 production."

25888642

Histone affects DDX58

| 1

Histone inhibits DDX58. 1 / 1

| 1

---

➶

reach

"In this study, we report that the histone methyltransferase enhancer of zeste homolog 2 (EZH2) inhibits RIG-I signal pathway in an methyltransferase independent manner."

23918984

His-Ser affects PYCARD

| 1

His-Ser inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Moreover, HS also inhibited the formation of NLRP3 and ASC specks and maintained the interaction of HSP70 with NLRP3 under nigericin treatment."

30874540

His-Ser affects CHUK

| 1

His-Ser inhibits CHUK. 1 / 1

| 1

---

➶

reach

"We further demonstrated experimentally and theoretically that the predicted inhibition of IKK activity was consistent with the observed HS dependent depletion of the IKKalpha and IKKbeta subunits in whole cell lysates."

29708974

His-Met affects FOS

| 1

His-Met inhibits FOS. 1 / 1

| 1

---

➶

reach

"We observed that activation of striatal hM 4 Di with CNO (2mg/kg, i.p.) before a cocaine challenge (15mg/kg, i.p.) significantly inhibited c-Fos activation in animals expressing hM 4 Di versus GFP controls (control were also administered CNO before cocaine challenge) [Figures XREF_FIG C, D; t (13) = 2.78, p < 0.02], suggesting that activation of hM 4 Di via CNO before cocaine challenge inhibited cAMP pathway activity by G i/o -coupled inhibition."

29686629

His-Gly affects EIF2AK1

| 1

His-Gly inhibits EIF2AK1. 1 / 1

| 1

---

➶

reach

"The inhibition of HRI by Hg 2+, but not other heavy metal ions, was reversed by NO * at the micromole level [XREF_BIBR]."

21463677

Hesperidin affects RELA

| 1

Hesperidin inhibits RELA. 1 / 1

| 1

---

➶

reach

"Hesperidin inhibits the expression of nuclear factor kappa B (NF-kappaB) subunit p65."

30038551

Heparin affects PYCARD

| 1

Heparin inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Heparin blocked internalization of ASC derived artificial nanovesicles in MLE12 cells (XREF_FIG)."

28082743

Heparin affects OAS1

| 1

Heparin inhibits OAS1. 1 / 1

| 1

---

➶

reach

"Heparin, furthermore, abolishes the antiviral activity of OAS1, demonstrating the requirement of the intracellular localization of OAS1 to inhibit the virus."

25517543

Heparin affects NFKBIA

| 1

Heparin inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Heparin, the specific in vitro inhibitor of PK-CKII inhibits the IkappaBalpha kinase of immunoprecipitated PK-CKII (lane 3), but not the IKK signalsome activity from unstimulated (lane 7) or TNF stimulated cells (lane 11)."

10398585

Hemoglobin affects NFKB1

| 1

Hemoglobin inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Decreased p50 suggested the presence of a high oxygen affinity hemoglobin (Hb) variant."

32151172

Hemin affects RELA

| 1

Hemin inhibits RELA. 1 / 1

| 1

---

➶

reach

"Hemin did not inhibit the nuclear localization of p65 protein induced by TPA stimulation in HT-29 cells and did not influence the TPA induced NF-kappaB-dependent transcriptional activity."

26087182

Hemin affects EIF2AK1

| 1

Hemin inhibits EIF2AK1. 1 / 1

| 1

---

➶

reach

"Hemin downregulated HRI promoter activity in a dose dependent manner : 25 muM and 50 muM caused 2-fold and 2.5-fold downregulation, respectively."

16500424

Hemin affects CASP1

| 1

Hemin inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Hemin and CORM-2 suppress the upregulation of caspase-1, caspase-11, caspase-1 p20, caspase-11 p20, and GSDMD, whereas caspase-1 is activated during pyroptosis by the canonical pyroptosome or caspase-11."

32351244

HG-9-91-01 affects MAPK8

1 |

HG-9-91-01 inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

HG-9-91-01 affects MAPK14

1 |

HG-9-91-01 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

HDL affects NLRP3

| 1

HDL inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"HDL reduces the proinflammatory role of cholesterol crystals, nigericin, and other NLRP3 and AIM2 inflammasome agonists, and several TLR agonists, leading to a decreased production of IL-1beta and IL-6."

31335262

HDL affects MAPK8

| 1

HDL inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells."

17437081

HDL affects JUN

| 1

HDL inhibits JUN. 1 / 1

| 1

---

➶

reach

"We also found that HDL inhibited activation of transcription factor AP-1 by TNF-alpha."

12479867

HDL affects IRF7

| 1

HDL inhibits IRF7. 1 / 1

| 1

---

➶

reach

"HDL suppressed this induction of Irf7 and Ip-10, but did not significantly affect Tnf-alpha expression (XREF_FIG)."

20974999

Guo affects IFNB1

| 1

Guo inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Lu X, Pan J, Tao J, Guo D. SARS-CoV nucleocapsid protein antagonizes IFN-beta response by targeting initial step of IFN-beta induction pathway, and its C-terminal region is critical for the antagonism."

32726355

Guggulsterone affects NFKBIA

| 1

Guggulsterone inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis."

15322087

Guggulsterone affects MYD88

| 1

Guggulsterone inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Guggulsterone, which has been used for centuries to treat many chronic diseases, inhibits the MyD88 dependent pathway by inhibiting the activity of inhibitor-kappaB kinase."

19000789

Guanine affects TLR7

| 1

Guanine inhibits TLR7. 1 / 1

| 1

---

➶

reach

"Guanine modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9 mediated immune responses of human immune cells."

25695778

Golotimod affects TLR7

1 |

Golotimod inhibits TLR7. 1 / 1

1 |

---

➶

drugbank

No evidence text available

Goe 6976 affects TYK2

1 |

Goe 6976 inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

Goe 6976 affects MAPK8

1 |

Goe 6976 inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

Goe 6976 affects IFNB1

| 1

Goe 6976 inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"By contrast, non treated or cDC treated with Go 6983, a non inhibiting analog of Go 6976, were able to robustly synthesize IFN-beta when they were stimulated with R848 or CpG."

25170774

Gly-Pro affects RELA

| 1

Gly-Pro inhibits RELA. 1 / 1

| 1

---

➶

reach

"NOLAN GP, GHOSH S, LIOU H-C, TEMPST P, BALTIMORE D : DNA Binding and I Inhibition of the Cloned p65 Subunit of NF-, a Rel related Polypeptide."

1386268

Gly-Pro affects NFKB1

| 1

Gly-Pro inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"626 / GP 04 Gufic Prize Suppression of NF-KB signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits Kuhad A, Chopra K Panjab University, Chandigarh, India."

21593975

Gly-Phe zwitterion affects TRIM25

| 1

Gly-Phe zwitterion inhibits TRIM25. 1 / 1

| 1

---

➶

reach

"However, except for BAT index, GF group significantly decreased the indices of liver, lung, kidney, muscle and EFP than the SPF group."

28367086

Gly-Phe zwitterion affects MYD88

| 1

Gly-Phe zwitterion inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Colonization of GF mice with a defined mixture of 46 Clostridium strains belonging to clusters XIVa and IV induces the differentiation of colonic Helios negative Tregs in a MyD88 independent manner."

26734006

Gly-Glu affects NLRP3

| 1

Gly-Glu inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"These effects of GE were largely abolished in NOD like receptor protein 3 (NLRP3)-deficient mice."

32081748

Gly-Asn affects IKBKE

| 1

Gly-Asn inhibits IKBKE. 1 / 1

| 1

---

➶

reach

"For example, Gn protein of NY-1 hantavirus and M protein of severe acute respiratory syndrome (SARS) coronavirus disrupt or prevent the formation of TRAF3, TBK1, and IKKepsilon complex to inhibit type I IFN production [XREF_BIBR, XREF_BIBR]."

23758787

Gly-Asn affects DDX58

| 1

Gly-Asn inhibits DDX58. 1 / 1

| 1

---

➶

reach

"Gn protein cytoplasmic tails inhibit RIG-I signaling but also serve a matrix protein function coordinating virion assembly and budding into intraluminal ER/cis-Golgi compartments for exocytosis."

24549848

Glucosamine affects NFKBIA

| 1

Glucosamine inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Glucosamine rescued the decrease of I-kappaBalpha induced by TGase 2 expression in a dose dependent manner."

18804908

Glu-Ser affects MYD88

| 1

Glu-Ser inhibits MYD88. 1 / 1

| 1

---

➶

reach

"The murine MyD88 gene was disrupted by homologous recombination in embryonic stem (ES) cells using a targeting vector designed to replace exons 4 and 5 [25]."

12217523

Glu-Ser affects MAPK8

| 1

Glu-Ser inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"The Jnk1 gene was inactivated by homologous recombination in ES cells using a targeting construct that lacks parts of the kinase domain (XREF_FIG a)."

11157052

Glu-Ser affects JUN

| 1

Glu-Ser inhibits JUN. 1 / 1

| 1

---

➶

reach

"Four hours of acute intracochlear ES decreased pJun immunoreactivity, supporting a hypothesis that ES inhibits apoptosis."

23907267

Glu-Met affects MYD88

| 1

Glu-Met inhibits MYD88. 1 / 1

| 1

---

➶

reach

"In the case of the MyD88 : IRAK4 : IRAK2 complex, the relative small size prevents detailed studies by EM and its tendency to be heterogeneous makes crystallization difficult."

20485341

Glu-Asp affects DDX58

| 1

Glu-Asp inhibits DDX58. 1 / 1

| 1

---

➶

reach

"Our findings reveal that C-terminal ED of NS1 (NS1/126-225) blocked RIG-I(N)-mediated IFN-β induction in an RNA binding-independent manner.Transcription factor IRF3 is a key innate immune system component that mediates IFN-β induction."

28717359

Glu-Ala affects NFKB1

| 1

Glu-Ala inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"EA also downregulated the expression of nuclear factor kappa B (NF-kappaB) p50, and TNF-alpha, in addition to reducing iNOS and apoptosis levels in the ischemic cortical penumbra to provide neuroprotection (Cheng et al., 2014a)."

29722298

Glu-Ala affects MYD88

| 1

Glu-Ala inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Furthermore, immunofluorescence staining also confirmed that 2Hz EA obviously suppressed the co-expression of microglia activation marker CD11b and TLR4 or MyD88, as well as the activation of NF-kappaB p65 in SNI rats."

31695479

Glu-Ala affects ITCH

| 1

Glu-Ala inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Some studies have shown that acupuncture reduces histamine induced itch in healthy volunteers XREF_BIBR, XREF_BIBR and that both manual acupuncture (MA) and electroacupuncture (EA), but not pseudoacupuncture, reduce the maximal intensity of itch when applied to the site of histamine injection XREF_BIBR."

30008609

Glu-Ala affects IKBKB

| 1

Glu-Ala inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"We reported previously that electroacupuncture (EA) could effectively suppress IKKbeta activation."

27716383

Gln-Glu affects CHUK

| 1

Gln-Glu inhibits CHUK. 1 / 1

| 1

---

➶

reach

"Similar to the result of MAPK pathway, QE, particularly QE albumen, significantly suppressed the activation of IKK-alpha and NF-kB p50, resulting in 54.29 +/- 1.21% and 16.67 +/- 1.14% fold protein reduction (p < 0.05; XREF_FIG), while QE yolk did not show any inhibition effect (p> 0.05; XREF_FIG)."

30083085

Geraniin affects RELA

| 1

Geraniin inhibits RELA. 1 / 1

| 1

---

➶

medscan

"Mechanistically, geraniin significantly downregulated Mcl-1 and impaired NF-κB p65 binding to the mcl-1 promoter."

28590547

GW820759X affects MAPK14

1 |

GW820759X inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

18789685

GW796921X affects MAPK14

1 |

GW796921X inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

18614366

GW796920X affects MAPK14

1 |

GW796920X inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

18614366

GW785974X affects MAPK14

1 |

GW785974X inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

18614366

GW785804X affects MAPK14

1 |

GW785804X inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

15317461

GW782912X affects MAPK14

1 |

GW782912X inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

18614366

GW780159X affects MAPK14

1 |

GW780159X inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

15317461

GW775608X affects MAPK14

1 |

GW775608X inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

18602262

GW770249X affects RIPK1

1 |

GW770249X inhibits RIPK1. 1 / 1

1 |

---

➶

tas

No evidence text available

29485864

GW770249A affects RIPK1

1 |

GW770249A inhibits RIPK1. 1 / 1

1 |

---

➶

tas

No evidence text available

29485864

GW769076X affects MAPK14

1 |

GW769076X inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

18602262

GW708893X affects MAPK14

1 |

GW708893X inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

17981461

GW701032X affects MAPK14

1 |

GW701032X inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

17981461

GW559768X affects MAPK14

1 |

GW559768X inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

27109867

GW434756X affects MAPK14

1 |

GW434756X inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

18818075

GW 501516 affects RELA

| 1

GW 501516 inhibits RELA. 1 / 1

| 1

---

➶

reach

"Furthermore, we found that GW501516 inhibited palmitate induced DNA binding of p65 to the MCP-1 promoter, as determined by chromatin immunoprecipitation (ChIP) analysis (XREF_FIG)."

21966476

GW 501516 affects MAPK8

| 1

GW 501516 inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"peroxisome proliferator-activated receptorδ-mediated messenger RNA stabilization of mitogen-activated protein kinase phosphatase -7 was responsible for the GW501516-mediated inhibition of JNK signaling."

23639976

GTP affects PYCARD

| 1

GTP inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"In the presence of GTP or phosphoenolpyruvate, theA -- ~-~ group had no significant effect relative to the basal (PNNP (aa -- 0) n.s., Table II), sug- gesting that GTP and phosphoenolpyruvate might block the weak ASC inhibi- tion."

6784766

GSK2656157 affects EIF2AK1

1 |

GSK2656157 inhibits EIF2AK1. 1 / 1

1 |

---

➶

tas

No evidence text available

24900593

GSK-994854A affects MAPK8

1 |

GSK-994854A inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

19056263

GS26575 affects STAT2

| 1

GS26575 inhibits STAT2. 1 / 1

| 1

---

➶

reach

"Inhibition of both M1 and M2 pathways increased bacterial burden in both WT and Stat2 -/- mice."

30337919

GS26575 affects RELA

| 1

GS26575 inhibits RELA. 1 / 1

| 1

---

➶

reach

"Collectively these results indicate that downregulation of B4GalT5 suppress M1 macrophage mediated adipose tissue inflammation by repressing JNK and NFkappaB and p65 activation, which are major pathways involved in inflammatory factors expression in macrophages XREF_BIBR, XREF_BIBR."

29415997

GS26575 affects NFKBIA

| 1

GS26575 inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"However, knockdown of SOCS3 substantially inhibited M1 activation induced IkappaBalpha degradation confirming that SOCS3 knockdown suppresses NF-kappaB activation upstream of DNA promoter binding."

24088176

GS26575 affects IRF7

| 1

GS26575 inhibits IRF7. 1 / 1

| 1

---

➶

reach

"In the model mice, we found a close relationship between the IAV induced ALI and the level and activity of IRF7 in local infectious sites, and also found that the reduced IRF7 level or activity in lungs of the mice treated with IRF7-rODN M1 led to the decreased mRNA levels of Ifna genes, the reduced neutrophil infiltration in the lungs and the prolonged survivals of the mice."

30667045

GNE-3511 affects MAPK8

1 |

GNE-3511 inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

25341110

GM3 affects JUN

| 1

GM3 inhibits JUN. 1 / 1

| 1

---

➶

reach

"GM3 synthase gene expression markedly suppressed the TNF-alpha-stimulated transcriptional activity of activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB), which are the controlling factors of MMP-9 expression."

21072492

GM affects CASP1

| 1

GM inhibits CASP1. 1 / 1

| 1

---

➶

reach

"In vitro, in nasal epithelial cells, LL37 stimulates inflammation and cell death; another GM compound, GM-0111, inhibits IL-6 and IL-8 release and blocks Caspase-1- and Caspase-8 -induced cell death (Thomas et al., 2017)."

32733248

GDP affects TYK2

| 1

GDP inhibits TYK2. 1 / 1

| 1

---

➶

reach

"Addition of GDP, which inhibits the activity of UCP1, decreased O 2 consumption of Tyk2 +/+, but not Tyk2-/- mitochondria."

23217260

GDP affects RELA

| 1

GDP inhibits RELA. 1 / 1

| 1

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➶

reach

"GDP bound kappaB-Ras supresses S276 phosphorylation and decreases the interaction of p65 with CBP and p300 leading to an inhibition of p65 transcriptional activity [XREF_BIBR]."

26999213

Fostamatinib affects TYK2

1 |

Fostamatinib inhibits TYK2. 1 / 1

1 |

---

➶

drugbank

No evidence text available

26516587

Fostamatinib affects TBK1

1 |

Fostamatinib inhibits TBK1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

26516587

Fostamatinib affects RIPK1

1 |

Fostamatinib inhibits RIPK1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

26516587

Fostamatinib affects MAPK14

1 |

Fostamatinib inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

26516587

Fostamatinib affects IKBKE

1 |

Fostamatinib inhibits IKBKE. 1 / 1

1 |

---

➶

drugbank

No evidence text available

26516587

Fostamatinib affects IKBKB

1 |

Fostamatinib inhibits IKBKB. 1 / 1

1 |

---

➶

drugbank

No evidence text available

26516587

Fostamatinib affects EIF2AK1

1 |

Fostamatinib inhibits EIF2AK1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

26516587

Fluticasone affects TBK1

| 1

Fluticasone inhibits TBK1. 1 / 1

| 1

---

➶

reach

"Fluticasone was found to inhibit the TbK1 and TbK2 mediated currents at an IC 50 of 0.7 muM."

29637069

Fedratinib affects JAK1

1 |

Fedratinib inhibits JAK1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

27473820

FLAVOPYRIDOL affects EIF2AK1

1 |

FLAVOPYRIDOL inhibits EIF2AK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

FILAMINAST affects MAPK14

1 |

FILAMINAST inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

20188577

FADH2 affects JAK1

| 1

FADH2 inhibits JAK1. 1 / 1

| 1

---

➶

reach

"Ruxolitinib is an FDA approved drug for the treatment of myelofibrosis and specifically inhibits Jak1 and Jak2."

27738655

Ertiprotafib affects IKBKB

1 |

Ertiprotafib inhibits IKBKB. 1 / 1

1 |

---

➶

drugbank

No evidence text available

17407812

Emricasan affects CASP1

1 |

Emricasan inhibits CASP1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

ERTIPROTAFIB affects IKBKB

1 |

ERTIPROTAFIB inhibits IKBKB. 1 / 1

1 |

---

➶

tas

No evidence text available

17407812

ENTRECTINIB affects JAK1

1 |

ENTRECTINIB inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

27003761

EHT1864 affects RELA

| 1

EHT1864 inhibits RELA. 1 / 1

| 1

---

➶

reach

"Furthermore, LPS promoted the nuclear translocation of NF-kappaB p65, which was blocked by EHT1864 (XREF_FIG)."

26939003

EC 3.5.1.98 (histone deacetylase) inhibitor affects IRF3

| 1

EC 3.5.1.98 (histone deacetylase) inhibitor inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Inhibition of HDAC6 activity by trichostatin A (TSA), a universal HDAC inhibitor, did not impair IRF-3 activation by TLR3 signaling, as measured by its specific phosphorylation, although, as expected, IFIT1 induction was inhibited (XREF_FIG)."

23532979

EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor affects FOS

| 1

EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor inhibits FOS. 1 / 1

| 1

---

➶

reach

"The results suggest that PKC and MAPK are likely to operate in series rather than in parallel because the inhibitory effect on c-Fos induction produced by the combination of PKC and MEK inhibitors is not additive."

18848604

EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor affects NFKBIA

| 1

EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Moreover, this acidosis induced IkappaBalpha degradation was also blocked by ERK inhibitors (XREF_FIG)."

27941930

EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor affects STAT1

| 1

EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor inhibits STAT1. 1 / 1

| 1

---

➶

reach

"To investigate this possibility, we determined the effect of FLUD (a specific STAT1 inhibitor), PD98059 (a specific MEK inhibitor), SB202190 (a specific p38 MAPK inhibitor), and LY294002 (a specific PI3K inhibitor) on gp120 induced STAT1 activation."

19103208

EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor affects RELA

| 1

EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor inhibits RELA. 1 / 1

| 1

---

➶

reach

"PI3K inhibitor LY249002 similar to bufalin could induce the downregulation of NF-kappaB p65, HIF1alpha and Plk1."

29568394

Dizocilpine affects FOS

| 1

Dizocilpine inhibits FOS. 1 / 1

| 1

---

➶

sparser

"MK-801 completely inhibited morphine-induced c-Fos in intact females but only caused partial inhibition in intact males; castrated males showed complete inhibition, which was reversed by testosterone, but gonadal steroids had no effect on this response in females."

11796656

Dimethyl fumarate affects RELA

1 |

Dimethyl fumarate inhibits RELA. 1 / 1

1 |

---

➶

drugbank

No evidence text available

26683377

Delta(9)-tetrahydrocannabinol affects IFNB1

| 1

Delta(9)-tetrahydrocannabinol inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"Cannabinoids Delta (9)-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide activated NF-kappaB and interferon-beta and STAT proinflammatory pathways in BV-2 microglial cells."

19910459

Dehydroascorbate affects PYCARD

| 1

Dehydroascorbate inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Dehydroascorbate treatment, which reduces ASC, abolished auxin maximum XREF_BIBR."

25522358

Dasatinib affects MAPK14

1 |

Dasatinib inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

18180381

DOVITINIB affects MAP3K7

1 |

DOVITINIB inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

DIHYDROGUAIARETIC ACID affects JUN

1 |

DIHYDROGUAIARETIC ACID inhibits JUN. 1 / 1

1 |

---

➶

tas

No evidence text available

24831826

DIHYDROGUAIARETIC ACID affects FOS

1 |

DIHYDROGUAIARETIC ACID inhibits FOS. 1 / 1

1 |

---

➶

tas

No evidence text available

24831826

DHCA affects CHUK

| 1

DHCA inhibits CHUK. 1 / 1

| 1

---

➶

reach

"DHCA reduced the production of pro inflammatory cytokines (TNF-alpha, IL-6, IL-1beta and CCL2) and mediators (iNOS, COX-2 and ROS) by down-regulating the activity of I-kappaB kinase and, subsequently, the DNA binding activity of NF-kappaB."

25802070

DEA/NO affects NFKBIA

| 1

DEA/NO inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"The enhancement of IkappaB-alpha degradation by DEA/NO correlated with an increase in the nuclear levels of the p50 and p65 subunits and DNA binding activity determined by electrophoretic mobility shift assay."

12500976

DAPT affects STAT1

| 1

DAPT inhibits STAT1. 1 / 1

| 1

---

➶

reach

"STAT1 activity of PC1 and TRPC4beta was inhibited by DAPT, indicating that STAT1 phosphorylation is associated with CTT cleaved from PC1."

29472562

DAPT affects RELA

| 1

DAPT inhibits RELA. 1 / 1

| 1

---

➶

reach

"Additionally, NF-kappaB and p65 immunofluorescence was attenuated by DAPT and LiCl; as opposed to this, IkappaBalpha protein expression was increased."

29049420

DAPT affects CASP1

| 1

DAPT inhibits CASP1. 1 / 1

| 1

---

➶

reach

"However, TLR4 KO mice received DAPT reduced APAP induced liver damage, NF-kappaB, NLRP3, and cleaved caspase-1 activation."

28286920

D-threo-isocitric acid affects TRAF6

| 1

D-threo-isocitric acid inhibits TRAF6. 1 / 1

| 1

---

➶

reach

"Crucially, ICT promoted proteasomal degradation of TRAF6, the critical adaptor protein that transduces RANKL and RANK signaling, and the inhibitory effect of ICT on osteoclastogenesis was reversed by the proteasomal inhibitor MG 132."

27813153

D-serine affects PYCARD

| 1

D-serine inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Although d-serine has been reported to inhibit system ASC, this inhibition is specific for ASCT2 while ASCT1 is the ASC transporter expressed in neurons."

18702664

D-ribofuranose affects FOS

| 1

D-ribofuranose inhibits FOS. 1 / 1

| 1

---

➶

reach

"D-ribose improves hemodynamic parameters, cardiac contractility and prevents the activation of pro apoptotic c-fos, demonstrating a neuroprotective effect of d-ribose during slow VT.."

17434215

D-ribofuranose affects DDX58

| 1

D-ribofuranose inhibits DDX58. 1 / 1

| 1

---

➶

reach

"The goal of our study was to begin to define the mechanism (s) by which chemically disparate base and ribose modifications suppress or evade RIG-I signaling."

27651356

D-glucopyranose affects MAPK8

1 |

D-glucopyranose inhibits MAPK8. 1 / 1

1 |

---

➶

ctd

No evidence text available

14505347

D-glucitol affects NLRP3

| 1

D-glucitol inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Sorbitol and thapsigargin did not suppress the activation of the NLRP3 inflammasome, whereas vincristine and paclitaxel strongly inhibited activation (XREF_FIG - XREF_FIG)."

31511697

D-glucaric acid affects IFIH1

| 1

D-glucaric acid inhibits IFIH1. 1 / 1

| 1

---

➶

reach

"The alanine substitution mutants CWD, GKR, and EEW reduced the activity of MDA5 as strongly as did wild-type NiV V, whereas the interference activities of RRE, ISI, and AWV were weaker than that of wild-type NiV V."

29769705

D-aspartic acid affects RELA

| 1

D-aspartic acid inhibits RELA. 1 / 1

| 1

---

➶

reach

"DAS significantly blocked the accumulation of the nuclear p65 protein in TNF-alpha-induced A7r5 cells by attenuating the TNF-alpha receptor complex through the dissociation of the TNF receptor associated death domain and TNF receptor associated factor 2."

24415531

D-alpha-aminobutyric acid affects MAPK14

| 1

D-alpha-aminobutyric acid inhibits MAPK14. 1 / 1

| 1

---

➶

reach

"Moreover, the ABU strain suppressed MAPK14 and FOS, downstream of TLR4, and IFIT1, downstream of IFN-beta."

27420101

Cysteine-S-acetamide affects OAS1

1 |

Cysteine-S-acetamide inhibits OAS1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

Cyclo(His-Pro) affects NLRP3

| 1

Cyclo(His-Pro) inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Cyclo (His Pro) inhibits NLRP3 inflammasome cascade in ALS microglial cells."

30439413

Cyanidin Chloride affects FOS

| 1

Cyanidin Chloride inhibits FOS. 1 / 1

| 1

---

➶

reach

"In addition, Cyanidin Chloride abrogated RANKL induced calcium oscillations, the activation of nuclear factor of activated T cells calcineurin dependent 1 (NFATc1), and the expression of c-Fos."

28771720

Custirsen affects NFKB1

1 |

Custirsen inhibits NFKB1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

Core protein affects STAT1

| 1

Core protein inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Conclusions: We provide additional evidence that HCV core protein alone suffices to produce STAT1 degradation, decrease nuclear P-STAT1 accumulation, and impair IFN signaling.Previously, we showed that triggering of CD81 on CD8ϩ T cells by HCV E2 results in release of RANTES, the natural ligand of CCR5."

| PMC

Collagen affects TLR7

| 1

Collagen inhibits TLR7. 1 / 1

| 1

---

➶

reach

"Suppression of collagen induced arthritis by intra-articular lentiviral vector mediated delivery of Toll like receptor 7 short hairpin RNA gene."

22089492

Collagen affects TBK1

| 1

Collagen inhibits TBK1. 1 / 1

| 1

---

➶

reach

"Reducing the activity or expression of TBK1 led to reduction in alpha-SMA stress fiber levels by 40-60% and deposition of ECM components collagen I and fibronectin by 50% in TGF-beta stimulated normal and IPF fibroblasts."

32159970

Collagen affects NFKBIA

| 1

Collagen inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Both inhibitors strongly reversed the sesamol (25 muM)-mediated inhibition of IKKbeta phosphorylation and IkappaBalpha degradation stimulated by collagen in washed platelets."

22168157

Chinese gallotannin affects MAPK14

1 |

Chinese gallotannin inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

Chelidonic acid affects CASP1

| 1

Chelidonic acid inhibits CASP1. 1 / 1

| 1

---

➶

medscan

"In addition, Chelidonic acid suppresses the activation and expression of caspase-1."

21320026

Carnosol affects JUN

| 1

Carnosol inhibits JUN. 1 / 1

| 1

---

➶

reach

"Huang et al indicated that carnosol, the major compound of RO extract responsible for antioxidant and chemopreventive activity, downregulates nuclear factor-kappaB and c-Jun, thus suppressing the MMP9."

29434776

CYC-116 affects TYK2

1 |

CYC-116 inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

CYC-116 affects TBK1

1 |

CYC-116 inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

CYC-116 affects MAPK8

1 |

CYC-116 inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

CYC-116 affects IKBKE

1 |

CYC-116 inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

CGP-52421 affects TBK1

1 |

CGP-52421 inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

19654408

CGP-52421 affects MAP3K7

1 |

CGP-52421 inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

19654408

CGP-52421 affects IKBKE

1 |

CGP-52421 inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

19654408

CEP-5214 affects MAPK8

1 |

CEP-5214 inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

14640546

CENISERTIB affects TYK2

1 |

CENISERTIB inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

CENISERTIB affects TBK1

1 |

CENISERTIB inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

CENISERTIB affects MAPK8

1 |

CENISERTIB inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

CENISERTIB affects IKBKE

1 |

CENISERTIB inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

CCCP affects TBK1

| 1

CCCP inhibits TBK1. 1 / 1

| 1

---

➶

reach

"Here, we show that CCCP inhibits activation of STING and its downstream signaling molecules, TBK1 and IRF3, but not STING translocation to the perinuclear region."

28859978

CCCP affects IRF3

| 1

CCCP inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Here, we show that CCCP inhibits activation of STING and its downstream signaling molecules, TBK1 and IRF3, but not STING translocation to the perinuclear region."

28859978

C646 affects NFKB1

| 1

C646 inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"In M1s, C646 decreases NFkB activation and expression of TNF, IL8, IL12B, iNOS, and IL1b [XREF_BIBR]."

29755698

C-Protein affects STAT1

| 1

C-Protein bound to STAT1 inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Sendai virus C protein binds STAT1 to block the formation of STAT1/STAT2 heterodimers or STAT1/STAT1 homodimers, which inhibit IFN signaling (18)."

31092569

C-Protein affects NLRP3

| 1

C-Protein inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"(b) EV71 proteases 2A and 3C and HPIV C protein induce NLRP3 protein degradation."

32133002

Bardoxolone methyl affects NFKBIA

1 |

Bardoxolone methyl inhibits NFKBIA. 1 / 1

1 |

---

➶

drugbank

No evidence text available

BMS-582949 affects MAPK14

1 |

BMS-582949 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

20804198

BLOC1S4 affects ITCH

| 1

BLOC1S4 inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Administration of CNO to activate the dynorphin neurons attenuated both histamine- and chloroquine evoked itch."

29556030

BKM120 affects RELA

| 1

BKM120 inhibits RELA. 1 / 1

| 1

---

➶

reach

"The BKM120 induced NF-kappaB p65 inhibition may be involved in the mediation of MGMT transcription to reverse TMZ-resistance in C6 glioma cells."

29151909

BITHIONOLATE SODIUM affects MAPK14

1 |

BITHIONOLATE SODIUM inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

BERKELEYAMIDE D affects CASP1

1 |

BERKELEYAMIDE D inhibits CASP1. 1 / 1

1 |

---

➶

tas

No evidence text available

18330993

BERKELEYAMIDE A affects CASP1

1 |

BERKELEYAMIDE A inhibits CASP1. 1 / 1

1 |

---

➶

tas

No evidence text available

18330993

BAPTA affects FOS

| 1

BAPTA inhibits FOS. 1 / 1

| 1

---

➶

reach

"The c-fos induction in m1 cells was inhibited by 1,2-bis (2-aminophenoxy) ethane-N, N, N ', N '-tetraacetic acid tetraacetoxymethyl ester (BAPTA-AM) and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride (W-7), but was not inhibited by prolonged treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA), suggesting that intracellular Ca2+ and calmodulin are involved in the induction."

7957639

B-Raf inhibitor affects JUN

| 1

B-Raf inhibitor inhibits JUN. 1 / 1

| 1

---

➶

reach

"C-Jun activity up-regulation by RAF inhibitors causes resistance to apoptosis."

25814555

B 581 affects RELA

1 |

B 581 inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

12085227

B 581 affects NFKB1

1 |

B 581 inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

12085227

Astaxanthin affects NFKBIA

1 |

Astaxanthin inhibits NFKBIA. 1 / 1

1 |

---

➶

drugbank

No evidence text available

14503852

Asp-Val affects STAT1

| 1

Asp-Val inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Such a selective antagonism on antiviral effect of IFN-alpha, but not IFN-gamma, correlated with down-regulated tyrosine phosphorylation and DNA binding activities of STAT1 and STAT3 transcription factors by DV."

15944325

Asp-Gly affects JUN

| 1

Asp-Gly inhibits JUN. 1 / 1

| 1

---

➶

reach

"FO attenuated the DG induced lung pro inflammatory status and down-regulated JNK and Jun pathway in the lung, which could be mediated by the prebiotic effects and metabolic products of FO in the large intestine."

23771791

Asp-Gly affects CASP1

| 1

Asp-Gly inhibits CASP1. 1 / 1

| 1

---

➶

reach

"DG administration inhibited caspase-1 activity and resulted in a ratio of 0.39 +/-0.16 (each n = 4, P < 0.01; Figures XREF_FIG and XREF_FIG)."

29674944

Asp-Glu affects RELA

| 1

Asp-Glu inhibits RELA. 1 / 1

| 1

---

➶

reach

"However, DE apparently inhibited the increase of NF-kappaB p65 at nucleus with minimal change of cytosolic expression."

23401716

Asp-Glu affects IRF3

| 1

Asp-Glu inhibits IRF3. 1 / 1

| 1

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➶

reach

"Target gene prediction in SAV responsive immune network genes showed that seventeen of the DE miRNAs could target 24 genes (e.g. IRF3, IRF7)."

28472924

Asp-Glu affects IFNB1

| 1

Asp-Glu inhibits IFNB1. 1 / 1

| 1

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➶

reach

"De Los Santos et al. determined that Lpro can restrict the induction of IFN-β mRNA [10]."

26511922

Asp-Asp affects MYD88

| 1

Asp-Asp inhibits MYD88. 1 / 1

| 1

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➶

reach

"Notably, only MyD88 DD and MyD88 can inhibit the homodimerization of full-length MyD88 (XREF_FIG)."

22155231

Asp-Asp affects IKBKB

| 1

Asp-Asp inhibits IKBKB. 1 / 1

| 1

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➶

reach

"Furthermore, both of the DD mutations significantly impair the ability of low concentrations of IKK2 to induce p105 serine 927 phosphorylation and proteolysis in transiently transfected 3T3 cells."

11976329

Asn-Asp affects STAT1

| 1

Asn-Asp inhibits STAT1. 1 / 1

| 1

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➶

reach

"The data generated for STAT4 has been used for the design and development of ND inhibitors of STAT1, STAT3 and STAT5."

24058784

Asn-Asp affects FOS

| 1

Asn-Asp inhibits FOS. 1 / 1

| 1

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➶

reach

"Nd Suppressed the Activation of c-Fos and NFATc1."

28955231

Arg-Val affects MYD88

| 1

Arg-Val inhibits MYD88. 1 / 1

| 1

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➶

reach

"Youn et al reported that RV inhibited MyD88 independent signaling pathways and targeted expression through TANK binding kinase 1 (TBK1) and receptor interacting protein 1 (RIP1) in the TIR-domain-containing adapter inducing interferon-beta (TRIF) complex."

26936125

Arg-Ser affects RELA

| 1

Arg-Ser inhibits RELA. 1 / 1

| 1

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➶

reach

"Treatment with HES or ALB, but not RS, prevented CD4 T-cell apoptosis (sham, 7.23% +/- 3.4%; HES, 10.2% +/- 4.1%; RS, 15.2% +/- 5.4%; ALB, 10.6% +/- 4.3%; 48 h) and nuclear factor-kappaB p65 activation (sham, 0.17 +/- 0.04; HES, 0.34 +/- 0.05; RS, 0.41 +/- 0.09; ALB, 0.25 +/- 0.09; 48 h) induced by TH/S early after resuscitation."

18461021

Arg-Ser affects ITCH

| 1

Arg-Ser inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Together with the in situ hybridization data, these results suggest that GABA A Rs inhibit the spinal relay of itch signals primarily at the level of dorsal horn interneurons rather than via inhibition of primary pruritoceptors."

30104684

Arg-Ser affects FOS

| 1

Arg-Ser inhibits FOS. 1 / 1

| 1

---

➶

reach

"However, others have shown that activated MT 1 Rs can also inhibit the induction of c-fos and jun B mRNA and c-Fos translation induced by forskolin [68]."

12628439

Arg-Met affects DDX58

| 1

Arg-Met inhibits DDX58. 1 / 1

| 1

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➶

reach

"Habjan M, Pichlmair A, Elliott RM, Overby AK, Glatter T, Gstaiger M, The FluAV NS1 protein interacts with the coil-coil domain of the E3 ligase TRIM25, thereby preventing the activation of RIG-I and subsequent IFN induction."

20538505

Arg-Leu affects NFKBIA

| 1

Arg-Leu inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Frantz B, Nordby EC, Bren G, Steffan N, Paya CV, Kincaid RL, ** Tocci MJ, O'Keefe SJ, O'Neill EA : Calcineurin acts in synergy with P/VIA to inactivate IKB and MAD3, an inhibitor of NF-KB."

7546397

Arg-Leu affects MAP3K7

| 1

Arg-Leu inhibits MAP3K7. 1 / 1

| 1

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➶

reach

"In a previous study, we have demonstrated that RL could inhibit the TAK1 and NF-kappaB, TAK1/AP-1, TBK1 and IRF3 pathways in LPS stimulated murine RAW 264.7 and human THP-1 cells."

26860973

Arg-Ile affects RELA

| 1

Arg-Ile inhibits RELA. 1 / 1

| 1

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➶

reach

"CI appeared to induce increases in p50 and p65 subunits as compared to RI mice on days 1 and 7, whereas RI alone reduced p65 on day 1 and p50 and p65 on day 7."

26422254

Aprepitant affects ITCH

| 1

Aprepitant inhibits ITCH. 1 / 1

| 1

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➶

reach

"Aprepitant at 80 mg o.d. for 1 week was shown to significantly reduce chronic itch of various etiologies, especially in patients with prurigo nodularis and atopic predisposition."

22418939

Andrographolide affects NFKB1

1 |

Andrographolide inhibits NFKB1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

Aloe emodin affects STAT1

| 1

Aloe emodin inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Aloe-emodin reversed STAT1 mediated response of NS-1-modulated suppression, as previously reported : galectin-3 triggering cytokine like regulation to activate JAK-STAT cascade in IFN-gamma-deficient cells (Jeon et al., 2010)."

24877694

Aldosterone affects JUN

| 1

Aldosterone inhibits JUN. 1 / 1

| 1

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➶

reach

"Aldosterone action : induction of p21 (ras) and fra-2 and transcription independent decrease in myc, jun, and fos."

10329965

Ala-Pro affects STING1

| 1

Ala-Pro inhibits STING1. 1 / 1

| 1

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➶

reach

"Last, our data also show that the JB419 cell-permeant nonhydrolyzable analog of Ap 4 A antagonizes STING to levels similar to those observed for Ap 4 A. Thus, this compound bears the potential for translation to the clinic and opens the way to the design of derived compounds with higher affinity for STING or increased retention time in the cGAMP binding pocket."

32494729

Ala-Pro affects STAT1

| 1

Ala-Pro inhibits STAT1. 1 / 1

| 1

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➶

reach

"However, Stat1 phosphorylation was markedly reduced in PAR2 transfected cells treated with the AP and poly (I : C) (XREF_FIG), which is consistent with a PAR2 dependent inhibition of the TLR3 pathway."

23871888

Ala-Pro affects RELA

| 1

Ala-Pro inhibits RELA. 1 / 1

| 1

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➶

reach

"Further, AP effectively inhibited UVA induced activation of pro angiogenic (iNOS and VEGF), inflammatory proteins (TNF-alpha, IL-6, and COX-2) expression and prevented the activation of NF-kappaB p65 in the mouse skin."

30521868

Ala-His affects CASP1

| 1

Ala-His inhibits CASP1. 1 / 1

| 1

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➶

reach

"Pretreatment of LA and AH significantly reduced caspase-1 activation without displaying host cell cytotoxicity in activated human mast cells."

31368553

Ala-Gly-Ser affects RELA

| 1

Ala-Gly-Ser inhibits RELA. 1 / 1

| 1

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➶

reach

"Transfection of AGS, NCI-N87 and SW480 cells with TAK1 specific, together with MEKK3 specific siRNAs led to a strong reduction of IKKalpha and beta, IkappaBalpha and RelA phosphorylation and suppressed the transactivation activity of RelA following H. pylori infection."

24418622

Acetylsalicylic acid affects NFKBIA

1 |

Acetylsalicylic acid inhibits NFKBIA. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10553090

Acetylcysteine affects IKBKB

1 |

Acetylcysteine inhibits IKBKB. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10788610

Acetylcysteine affects CHUK

1 |

Acetylcysteine inhibits CHUK. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10788610

Ac-Asp-Glu-Val-Asp-H affects JUN

| 1

Ac-Asp-Glu-Val-Asp-H inhibits JUN. 1 / 1

| 1

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➶

reach

"In addition, nuclear cyclic AMP responsive element (CRE) - and activator protein 1 (AP-1) DNA binding activities were increased 2 h after K+ and serum withdrawal, and these increases were inhibited by cycloheximide, Ac-DEVD-CHO and PACAP 38."

10617323

Abemaciclib affects CHUK

1 |

Abemaciclib inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

AZD4547 affects RIPK1

1 |

AZD4547 inhibits RIPK1. 1 / 1

1 |

---

➶

tas

No evidence text available

AZD-6703 affects MAPK14

1 |

AZD-6703 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

22608965

AZD-4547 affects RIPK1

1 |

AZD-4547 inhibits RIPK1. 1 / 1

1 |

---

➶

tas

No evidence text available

ATP affects TBK1

| 1

ATP inhibits TBK1. 1 / 1

| 1

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➶

reach

"To pursue targeting TBK1 by pharmacological inhibition, we used BX795, an ATP competitive inhibitor of TBK1."

24962318

ATP affects NFKB1

| 1

ATP inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"In addition, previous kinetic analyses using cell lysates from intestinal mucosa of IBD patients indicated marked acceleration of ATP dependent degradation of p105 occurs in the presence of proteasomes from IBD patients [XREF_BIBR]."

26439841

ATP affects MAPK8

| 1

ATP inhibits MAPK8. 1 / 1

| 1

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➶

reach

"ATP induced JNK1 activation was reduced by PI-PLC, IP (3) receptor, PKC and Src inhibitors and by gadolinium, nifedipine and verapamil or a Ca (2+)-free medium."

18625195

ATP affects MAPK14

| 1

ATP inhibits MAPK14. 1 / 1

| 1

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➶

reach

"O'Neill EA : The activation state of ~ 38 mitosen- stress induced cytokine production by pyridinylimidazoles; activated drotein kinase determines the efficiency of ATP inhibition of CSBP kinase."

10419844

ATP affects IFIH1

| 1

ATP inhibits IFIH1. 1 / 1

| 1

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➶

reach

"Based on these models of RIG-I and MDA5 described above, one may conclude that ATP hydrolysis negatively regulates the signaling activity of MDA5, while it is required for the RIG-I signaling activity."

26410598

ATP affects FOS

| 1

ATP inhibits FOS. 1 / 1

| 1

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➶

reach

"The ATP induced c-fos increment was inhibited by three P (2Y) receptor antagonists-suramin, reactive blue, and DIDS by 99 +/-3, 89 +/-7, and 61 +/-14%, respectively."

11038302

ATP affects CASP1

| 1

ATP bound to its inhibits CASP1. 1 / 1

| 1

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➶

reach

"Inhibition of the P2x7 pathway in vitro restores the potential of CD34 + HPC differentiation into T cells in INR patients, further confirming this view.37 The binding of ATP with its receptor, P2x7, induces the formation of inflammatory bodies, activates the caspase-1 signaling pathway, and promotes the secretion of the proinflammatory cytokines IL-1beta and IL-18, thus inducing host cell apoptosis and pyroptosis.38 Another study by Guo etal."

31965635

AT-9283 affects TYK2

1 |

AT-9283 inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

19143567

AST-487 affects MAP3K7

1 |

AST-487 inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

AST-487 affects IKBKB

1 |

AST-487 inhibits IKBKB. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

AST-487 affects CHUK

1 |

AST-487 inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

AS605240 affects FOS

| 1

AS605240 inhibits FOS. 1 / 1

| 1

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➶

reach

"Noteworthy, AS605240 (1mg/kg) was able to prevent c-Fos and phospho-Akt immunopositivity at the spinal cord of trypsin injected mice, either into the back of the neck or the paws."

22001656

ARRY-797 affects MAPK14

1 |

ARRY-797 inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

19950901

ANA971 affects TLR7

1 |

ANA971 inhibits TLR7. 1 / 1

1 |

---

➶

drugbank

No evidence text available

AICA ribonucleotide affects TBK1

| 1

AICA ribonucleotide inhibits TBK1. 1 / 1

| 1

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➶

reach

"AICAR induced inhibition of Ccl2 expression was significantly attenuated in TBK1 KO cells."

29425491

AICA ribonucleotide affects ITCH

| 1

AICA ribonucleotide inhibits ITCH. 1 / 1

| 1

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➶

reach

"Finally, as it was recently suggested that AICAR treatment led to TAp73 stabilisation by inhibiting the E3 ligase Itch, 25 we utilised Itch -/- MEFs to evaluate the stability of TAp73 upon hypoxia and AICAR treatment."

30057793

AHL affects NFKBIA

| 1

AHL inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"16 Our results also suggest that AHL mediated disruption of IkappaBalpha dependent NF-kappaB signaling renders cancer cells susceptible to TNF- and TRAIL induced apoptosis (XREF_SUPPLEMENTARY; see also XREF_FIG)."

23517377

AGRO100 affects IKBKG

1 |

AGRO100 inhibits IKBKG. 1 / 1

1 |

---

➶

drugbank

No evidence text available

ADP affects NLRP3

| 1

ADP inhibits NLRP3. 1 / 1

| 1

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➶

reach

"CD39 expressing DCs converted extracellular ATP to ADP and AMP molecules, which were critical to down-regulate NLRP3 inflammasome and protect the host from experimental autoimmune encephalomyelitis (EAE)."

29033934

ADP affects IKBKB

| 1

ADP inhibits IKBKB. 1 / 1

| 1

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➶

reach

"The results are represented as pseudo-Dixon plots (i.e., ratio of the rate of product formed in the absence to that in the presence of inhibitor versus concentration of inhibitor) to more easily gauge the relative inhibition of each phosphorylation product.The use of ADP, which has been shown to inhibit IKK-1 and IKK-2 competitively with respect to ATP [16], showed an even more pronounced effect, with the enzyme catalyzed IkappaBalpha phosphorylation inhibited considerably more potently than autophosphorylation with both IKK-1 and IKK-2."

12054687

ABT-737 affects JUN

| 1

ABT-737 inhibits JUN. 1 / 1

| 1

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➶

reach

"Our results show that ABT-737 inhibited HeLa cell proliferation and activated JNK and its downstream target c-Jun, which caused the up-regulation of Bim expression."

23285061

ABEMACICLIB affects CHUK

1 |

ABEMACICLIB inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

9H-xanthine affects RELA

| 1

9H-xanthine inhibits RELA. 1 / 1

| 1

---

➶

reach

"XAN treatment inhibited the dimerization of TLR4 and transcriptional activity of NF-kappaB in HEK293T cells and decreased p65 accumulation in nucleus and pro inflammatory cytokines production in RAW264.7 cells receiving LPS treatment."

32468498

9-(tetrahydrofuryl)adenine affects CASP1

| 1

9-(tetrahydrofuryl)adenine inhibits CASP1. 1 / 1

| 1

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➶

reach

"This was the case, with the CGS21680 induced up-regulation in LPS and ATP induced active caspase-1 being reduced by SQ22536 and H-89 (XREF_FIG)."

24352507

8-Br-cGMP affects TRAF6

| 1

8-Br-cGMP inhibits TRAF6. 1 / 1

| 1

---

➶

reach

"Quantitative RT-PCR analysis showed that 8-Br-cGMP increased miR-146a and decreased IRAK1 and TRAF6 (XREF_FIG)."

24316060

8-Br-cAMP affects MAPK8

| 1

8-Br-cAMP inhibits MAPK8. 1 / 1

| 1

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➶

reach

"Similarly to the effect of PDE4 inhibition, 8-Br-cAMP selectively inhibited NTHi induced activation of JNK2 but not JNK1 in HMEEC cells (XREF_FIG)."

23575688

8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM affects MAPK14

1 |

8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

7,9-dihydro-1H-purine-2,6,8(3H)-trione affects STAT1

| 1

7,9-dihydro-1H-purine-2,6,8(3H)-trione inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Furthermore, urate inhibited the activation of JAK2, STAT1, and STAT3."

19636222

7,8-dihydromonapterin affects CASP1

| 1

7,8-dihydromonapterin inhibits CASP1. 1 / 1

| 1

---

➶

eidos

"This study showed that DHM significantly inhibited the expression of caspase-1 , down-regulated the expression and contents of IL-1beta and IL-18 and seemed to reduce the activation of pyroptosis ."

32448367

6alpha-methylprednisolone affects STAT1

| 1

6alpha-methylprednisolone inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Moreover, methylprednisolone inhibited activation of STAT-1, STAT-3, and STAT-5 in IL-2-cultured NK cells but only partially in IL-15-cultured NK cells."

21716670

6-aminonicotinamide affects STING1

| 1

6-aminonicotinamide inhibits STING1. 1 / 1

| 1

---

➶

reach

"Both GA and 6-AN enhanced STING degradation compared to mock treated cells."

29241549

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one affects MAP3K7

1 |

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one affects JAK1

| 1

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one inhibits JAK1. 1 / 1

| 1

---

➶

reach

"18 In particular, R406 (the active metabolite of R788) inhibits JAK2> JAK1> SYK> JAK3."

29923438

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one affects IKBKB

1 |

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one inhibits IKBKB. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one affects CHUK

1 |

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine affects MAPK14

1 |

6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE affects MAPK8

1 |

6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE inhibits MAPK8. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

5beta-dihydrotestosterone affects RELA

| 1

5beta-dihydrotestosterone inhibits RELA. 1 / 1

| 1

---

➶

reach

"Importantly, the increase in NF-kappaB (p65) was completely negated in arteries from rats treated with DHT and 20-6,15-HEDE (XREF_FIG)."

21321301

5beta-dihydrotestosterone affects NFKB1

| 1

5beta-dihydrotestosterone inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"DHT and TMZ synergistically reduce cancer cell viability, NFkB activity, and markedly halt cell cycle progression."

30399573

5alpha-cholestane-3beta,5,6beta-triol affects JUN

| 1

5alpha-cholestane-3beta,5,6beta-triol inhibits JUN. 1 / 1

| 1

---

➶

reach

"Along the same line, CT reduced the c-jun induction and T-47D growth stimulation by epidermal growth factor (EGF) and insulin."

9164825

5Z-7-oxozeaenol affects STAT1

| 1

5Z-7-oxozeaenol inhibits STAT1. 1 / 1

| 1

---

➶

reach

"The inhibitory effect was specific to Nef, because 5Z-7-oxozeaenol did not inhibit GM-CSF-induced activation of Stat1 and Stat5 in M2-MPhi (XREF_FIG)."

24874739

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects JUN

| 1

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole inhibits JUN. 1 / 1

| 1

---

➶

reach

"In contrast, omeprazole reduced binding of acidic bile salt stimulated c-jun and c-fos to the IL-8 promoter to control levels (XREF_FIG)."

24048734

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects CASP1

| 1

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole inhibits CASP1. 1 / 1

| 1

---

➶

reach

"In the present study, omeprazole was used as a counterpoint for a treatment to inhibit caspase-1."

27053298

5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester affects CASP1

| 1

5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Although we did observe ATP release from LPS treated neutrophils (XREF_SUPPLEMENTARY), KN62 failed to block caspase-1 activation or IL-1beta production (XREF_FIG)."

22496641

5-hydroxymethylfurfural affects NFKB1

| 1

5-hydroxymethylfurfural inhibits NFKB1. 1 / 1

| 1

---

➶

eidos

"5-HMF reduces the P50 ( PO2 at which 50 % of hemoglobin is saturated with oxygen , a parameter indicating the position of the ODC ) via allosteric modification of the hemoglobin [ 10 ] ."

32360083

5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate affects STAT1

| 1

5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate inhibits STAT1. 1 / 1

| 1

---

➶

sparser

"Acacetin inhibited Stat-1 (Tyr701) and Stat-3 (Tyr705) phosphorylation, and down-regulated pro-angiogenic factors including VEGF, eNOS, iNOS, MMP-2 and bFGF in HUVEC."

23943785

5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate affects RELA

| 1

5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate inhibits RELA. 1 / 1

| 1

---

➶

reach

"Additionally, paralleling Kv1.3 inhibition, Acacetin also inhibited Ca (2+) influx, the Ca (2+)-activated transcription factors NFAT1, NF-kappaB p65 and p50 activity, and proliferation as well as IL-2 production."

25301362

5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate affects NFKB1

| 1

5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Additionally, paralleling Kv1.3 inhibition, Acacetin also inhibited Ca (2+) influx, the Ca (2+)-activated transcription factors NFAT1, NF-kappaB p65 and p50 activity, and proliferation as well as IL-2 production."

25301362

5-formyluracil affects NFKBIA

| 1

5-formyluracil inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"5-FU induced IkappaBalpha degradation and promoted both NF-kappaB nuclear translocation and its DNA binding activity."

12584750

5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine affects MAP3K7

1 |

5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine affects JAK1

1 |

5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2-pyrimidinamine affects MAPK8

1 |

5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2-pyrimidinamine inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

5-aminolevulinic acid affects RIPK1

| 1

5-aminolevulinic acid inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"5-Aminolevulinic Acid Mediated Sonodynamic Therapy Inhibits RIPK1 and RIPK3 Dependent Necroptosis in THP-1-Derived Foam Cells."

26911899

5-aminolevulinic acid affects PYCARD

| 1

5-aminolevulinic acid inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"However, addition of 5-aminolevulinic acid (ALA) to cultures treated with PIA plus TCB decreased the ability of ASC to prevent URO accumulation, suggesting that the effectiveness of ASC was dependent on the intracellular concentration of ALA or its metabolites."

8346921

5-Nitro-2-(3-phenylpropylamino)benzoic acid affects MAPK14

| 1

5-Nitro-2-(3-phenylpropylamino)benzoic acid inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"On the other hand, 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB), which disrupts anion channels, did not inhibit translocation of VacA to lipid rafts or VacA-induced activation of p38 mitogen-activated protein kinase, but inhibited VacA internalization followed by vacuolation."

17030583

5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE affects MAPK8

1 |

5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE inhibits MAPK8. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

5-(tetradecyloxy)-2-furoic acid affects JAK1

| 1

5-(tetradecyloxy)-2-furoic acid inhibits JAK1. 1 / 1

| 1

---

➶

reach

"The kinase inhibitor Tofacitinib (Tofa), a small molecule that preferentially blocks JAK1 activity, was administered in a clinically relevant regimen to mimic the human exposure, at doses that largely block phospho-Stat1 activation by IFN, alone or prior to a 2-hr parenteral IFN challenge."

26824662

5-(5,6-dimethoxy-1-benzimidazolyl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide affects MYD88

| 1

5-(5,6-dimethoxy-1-benzimidazolyl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide inhibits MYD88. 1 / 1

| 1

---

➶

reach

"In addition, GW843682X treatment for 12 to 24 h induced cell death and down-regulated MyD88, but neither of these roles contributed to the down-regulation of TNF-alpha, as TNF-alpha gene expression was up-regulated at 1 h. Furthermore, GW843682X inhibited Pam3CSK4 induced activation of ERK and NF-kappaB, which contributed to Pam3CSK4 induced up-regulation of TNF-alpha."

24205328

5-(5,6-dimethoxy-1-benzimidazolyl)-3-[(2-methylsulfonylphenyl)methoxy]-2-thiophenecarbonitrile affects TBK1

1 |

5-(5,6-dimethoxy-1-benzimidazolyl)-3-[(2-methylsulfonylphenyl)methoxy]-2-thiophenecarbonitrile inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

24462666

5-(2-phenyl-3-pyrazolo[1,5-a]pyridinyl)-2H-pyrazolo[3,4-c]pyridazin-3-amine affects MAPK14

1 |

5-(2-phenyl-3-pyrazolo[1,5-a]pyridinyl)-2H-pyrazolo[3,4-c]pyridazin-3-amine inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

18077363

5-(2-methylpiperazine-1-sulfonyl)isoquinoline affects STAT1

| 1

5-(2-methylpiperazine-1-sulfonyl)isoquinoline inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Conditioned medium from T84 cells infected with EHEC O157 : H7 suppressed Stat1 activation, and this was not reversed by treatment with proteinases or heat inactivation."

16495555

5(S)-HETE affects MAPK8

| 1

5(S)-HETE inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"This report documents the fact that inhibition of arachidonate 5-lipoxygenase induces rapid activation of c-Jun N-terminal kinase (JNK) in human prostate cancer cells which is prevented by the 5-lipoxygenase metabolite, 5(S)-HETE."

12859962

4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde affects MAPK14

1 |

4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

4-methyl-N-[3-(morpholin-4-yl)phenyl]-3-[3-(piperidin-4-yl)-1,2-benzoxazol-6-yl]benzamide affects MAPK14

1 |

4-methyl-N-[3-(morpholin-4-yl)phenyl]-3-[3-(piperidin-4-yl)-1,2-benzoxazol-6-yl]benzamide inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

18789685

4-hydroxynon-2-enal affects RELA

1 |

4-hydroxynon-2-enal inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

11146106

4-hydroxynon-2-enal affects NFKB1

1 |

4-hydroxynon-2-enal inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

11146106

4-aminobenzoic acid affects NFKB1

| 1

4-aminobenzoic acid inhibits NFKB1. 1 / 1

| 1

---

➶

reach

"Finally, the eNAMPT neutralizing pAb significantly reduced MCT induced vascular remodeling, PAH hemodynamic alterations and NFkB activation."

32142369

4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone affects MAP3K7

1 |

4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

4-[[9-[(3R)-3-oxolanyl]-8-(2,4,6-trifluoroanilino)-2-purinyl]amino]-1-cyclohexanol affects MAPK8

1 |

4-[[9-[(3R)-3-oxolanyl]-8-(2,4,6-trifluoroanilino)-2-purinyl]amino]-1-cyclohexanol inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

22244937

4-[[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone affects TLR7

| 1

4-[[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone inhibits TLR7. 1 / 1

| 1

---

➶

reach

"Note, for example, that there is at most a low level of TLR1 induction by 5FU and nutlin in the primary cells from 18 subjects and there is even a general repression of TLR7 by nutlin."

21483755

4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-morpholinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-pyridinone affects TYK2

1 |

4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-morpholinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-pyridinone inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-morpholinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-pyridinone affects JAK1

1 |

4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-morpholinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-pyridinone inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE affects MAPK14

1 |

4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

4-[4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1H-imidazol-5-yl]pyridine affects MAPK14

1 |

4-[4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1H-imidazol-5-yl]pyridine inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

24913411

4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine affects MAPK14

1 |

4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide affects MAPK14

1 |

4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide inhibits MAPK14. 1 / 1

1 |

---

➶

signor

"In steady-state kinetics experiments, cmpd1 was observed to prevent the p38alpha-dependent phosphorylation (k(i)(app) = 330 nm) of the splice variant of mitogen-activated protein kinase-activated protein kinase 2 (mk2a) that contains a docking domain for p38alpha and p38beta"

15362850

4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE affects MAPK14

1 |

4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

4-[(7-oxo-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-ylidene)methylamino]-N-(2-pyridinyl)benzenesulfonamide affects TYK2

1 |

4-[(7-oxo-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-ylidene)methylamino]-N-(2-pyridinyl)benzenesulfonamide inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

4-[(7-oxo-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-ylidene)methylamino]-N-(2-pyridinyl)benzenesulfonamide affects MAPK8

1 |

4-[(7-oxo-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-ylidene)methylamino]-N-(2-pyridinyl)benzenesulfonamide inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE affects MAPK14

1 |

4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

4-(ethoxymethylene)-2-phenyloxazol-5-one affects CASP1

| 1

4-(ethoxymethylene)-2-phenyloxazol-5-one inhibits CASP1. 1 / 1

| 1

---

➶

reach

"As shown in Figures XREF_FIG and XREF_FIG, the enhanced caspase-1 activity and IL-1beta production induced by HG were markedly suppressed by gp91 phox shRNA or by NADPH inhibitors APO and DPI."

25834832

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one affects IKBKE

| 1

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one inhibits IKBKE. 1 / 1

| 1

---

➶

reach

"In summary, we identified IKBKE as a direct target of STAT3 and nicotine and NNK induced IKBKE via STAT3 in human NSCLC cells."

22330135

4-(Fluorophenyl)-1-Cyclopropylmethyl-5-(2-Amino-4-Pyrimidinyl)Imidazole affects MAPK14

1 |

4-(Fluorophenyl)-1-Cyclopropylmethyl-5-(2-Amino-4-Pyrimidinyl)Imidazole inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE affects MAPK14

1 |

4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

4-(2-methyl-3-propan-2-yl-4-imidazolyl)-N-(4-methylsulfonylphenyl)-2-pyrimidinamine affects MAPK8

1 |

4-(2-methyl-3-propan-2-yl-4-imidazolyl)-N-(4-methylsulfonylphenyl)-2-pyrimidinamine inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE affects MAPK14

1 |

4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID affects CASP1

1 |

3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID inhibits CASP1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

3-methylcholanthrene affects STAT1

| 1

3-methylcholanthrene inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Growth of transplanted MCA induced Stat1-/- sarcomas was suppressed in wild-type mice compared to growth in Stat1-/- and immunocompromised recipients."

23958683

3-methylcholanthrene affects RELA

| 1

3-methylcholanthrene inhibits RELA. 1 / 1

| 1

---

➶

reach

"We next demonstrated that TCDC- and MC induced p65 glutathionylation could be reversed by incubation with a reducing agent, DTT."

24512908

3-methylcholanthrene affects IKBKB

| 1

3-methylcholanthrene inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"We investigated MC responses in mice with MC specific inactivation of IKK2 or NF-kappaB essential modulator (NEMO), or animals with MC specific expression of a mutant, constitutively active IKK2."

25176657

3-methyladenine affects STING1

| 1

3-methyladenine inhibits STING1. 1 / 1

| 1

---

➶

reach

"Because this cell death pathway is inhibited by 3-methyladenine and siRNA knockdown of Beclin-1 or STING, autophagic recognition of the inclusion contents appears to be the initial step in induction of the apoptotic pathway."

28514660

3-methyl-9H-xanthine affects STAT1

| 1

3-methyl-9H-xanthine inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Human VSMCs were transfected with a control or AIP1 siRNA followed by treatment with human IFN-gamma in the absence or presence of a specific inhibitor to JAK2 (AG490), STAT1 (Fludarabine, a purine analog that has been shown to specifically inhibit STAT1 in VSMC) 38 or STAT3 (Stattic, a nonpeptide small molecule inhibitor of STAT3 activation and dimerization) 39."

21700930

3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamide affects MAPK14

1 |

3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamide inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

3-fluoro-5-morpholin-4-yl-N-[1-(2-pyridin-4-ylethyl)-1H-indol-6-yl]benzamide affects MAPK14

1 |

3-fluoro-5-morpholin-4-yl-N-[1-(2-pyridin-4-ylethyl)-1H-indol-6-yl]benzamide inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

16783341

3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]propanenitrile affects MAP3K7

1 |

3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]propanenitrile inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

3-anilino-4-[1-[3-(1-imidazolyl)propyl]-3-indolyl]pyrrole-2,5-dione affects JAK1

1 |

3-anilino-4-[1-[3-(1-imidazolyl)propyl]-3-indolyl]pyrrole-2,5-dione inhibits JAK1. 1 / 1

1 |

---

➶

tas

No evidence text available

24461299

3-[[4-(dimethylamino)-1-oxobut-2-enyl]amino]-N-[4-[[4-(2-phenyl-3-pyrazolo[1,5-a]pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide affects MAPK8

1 |

3-[[4-(dimethylamino)-1-oxobut-2-enyl]amino]-N-[4-[[4-(2-phenyl-3-pyrazolo[1,5-a]pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

25415535

3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole affects MAPK8

1 |

3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

3-[1-[3-(dimethylamino)propyl]-5-methoxy-3-indolyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione affects FOS

| 1

3-[1-[3-(dimethylamino)propyl]-5-methoxy-3-indolyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione inhibits FOS. 1 / 1

| 1

---

➶

reach

"In agreement with this prediction, we found that the PKC inhibitor GO-6983 inhibited 57% of the LYCD induced c-fos elevation (data not shown)."

29734114

3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE affects MAPK14

1 |

3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE affects MAPK14

1 |

3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

3-(trimethylsilyl)propane-1-sulfonic acid affects NFKBIA

| 1

3-(trimethylsilyl)propane-1-sulfonic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Since an increase in reactive oxygen species (ROS) has been associated with clinical IBD, we determined the effects of DSS exposure on ROS and the effect of ROS inhibitors on the DSS induced activation of phospho-IkappaBalpha, NFkappaB, and IL-8 in these different models of intestinal inflammation."

19085995

3-(trimethylsilyl)propane-1-sulfonic acid affects IKBKB

| 1

3-(trimethylsilyl)propane-1-sulfonic acid inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Thus, oral administration of curcumin inhibited the DSS induced colitis, and repressed the signal transduction mediated by JAK-STAT3, XREF_BIBR, XREF_BIBR as well as IKKbeta activity."

29629345

3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-3-piperidinyl]-2-thiophenecarboxamide affects MAP3K7

1 |

3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-3-piperidinyl]-2-thiophenecarboxamide inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-3-piperidinyl]-2-thiophenecarboxamide affects CHUK

1 |

3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-3-piperidinyl]-2-thiophenecarboxamide inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3R)-3-piperidinyl]-2-thiophenecarboxamide affects MAP3K7

1 |

3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3R)-3-piperidinyl]-2-thiophenecarboxamide inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3R)-3-piperidinyl]-2-thiophenecarboxamide affects CHUK

1 |

3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3R)-3-piperidinyl]-2-thiophenecarboxamide inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxo-6-quinazolinyl)amino]phenyl]benzamide affects MAPK14

1 |

3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxo-6-quinazolinyl)amino]phenyl]benzamide inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA affects MAPK14

1 |

3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

3-(1H-indol-3-yl)propanoic acid affects NFKBIA

| 1

3-(1H-indol-3-yl)propanoic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"Moreover, we demonstrated that iPA was also able to slow down the NFkappaB pathway by increasing its direct inhibitor IkappaBalpha in both CF and TNFalpha stimulated non CF cells, thus suggesting that iPA can act as a NFkappaB inhibitor decreasing the production of the pro inflammatory chemokines IL-8 and RANTES."

29230506

3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE affects MAPK14

1 |

3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

3,5-dinitrosalicylic acid affects STAT1

| 1

3,5-dinitrosalicylic acid inhibits STAT1. 1 / 1

| 1

---

➶

reach

"It is somewhat surprising that the combination of TRAF DNs including TRAF-1,-2, -3, and -5 could not efficiently block the induction of STAT-1."

15165826

3,4-dihydroxyphenylethyleneglycol affects FOS

| 1

3,4-dihydroxyphenylethyleneglycol inhibits FOS. 1 / 1

| 1

---

➶

reach

"The DHPG induced c-fos up-regulation was only blocked by U73122, but not by KN62 (XREF_FIG)."

19446601

3,4,5-trihydroxybenzoic acid [(2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl] ester affects STAT1

1 |

3,4,5-trihydroxybenzoic acid [(2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl] ester inhibits STAT1. 1 / 1

1 |

---

➶

tas

No evidence text available

24417609

25-hydroxycholesterol affects NLRP3

| 1

25-hydroxycholesterol inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"More importantly, the Ch25h substrate 25-hydroxycholesterol is able to inhibit NLRP3 inflammasome activation and IL-1beta production 140."

26121197

24-methylidenelophenol affects STAT1

| 1

24-methylidenelophenol inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Gramisterol increased IFN-gamma production and prevented the dysfunctional immune system of leukemic mice by enhancing pSTAT1 transcription signal controlling proliferation and functions of hematopoietic cells in the spleen."

26752299

2-tert-butylhydroquinone affects NLRP3

| 1

2-tert-butylhydroquinone inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"TBHQ is reported to inhibit NLRP3 inflammasome activation and consequent IL-1beta production and secretion in cerebral ischemia reperfusion injury of rats XREF_BIBR."

30014902

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one affects TBK1

1 |

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one affects STAT2

| 1

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one inhibits STAT2. 1 / 1

| 1

---

➶

reach

"However, in Stat1 [-/-] BMMs the 4-hour P6 pulse significantly impaired the delayed activation of Stat2 (XREF_FIG, bottom panels)."

26019270

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one affects MAPK8

1 |

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one affects IRF3

| 1

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one inhibits IRF3. 1 / 1

| 1

---

➶

reach

"IRF-3, the translocation of which from the cytoplasm to the nucleus is crucial for the activation of antiviral signaling, can be inhibited and detained in the cytoplasm by SARS-CoV P6 (Spiegel et al., 2005) ."

25907116

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one affects IKBKE

1 |

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one affects IKBKB

1 |

2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one inhibits IKBKB. 1 / 1

1 |

---

➶

tas

No evidence text available

11934592

2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one affects CHUK

1 |

2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

2-hydroxyethyl methacrylate affects RELA

1 |

2-hydroxyethyl methacrylate inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

19176594

2-hydroxy-17beta-estradiol affects RELA

| 1

2-hydroxy-17beta-estradiol inhibits RELA. 1 / 1

| 1

---

➶

reach

"Overexpressing optimal concentrations of pre-miR-146a, -451, -98 (20 nmol/L each), and -708 (1 nmol/L) in ECs also reduced sSMC-activations of EC IkappaBalpha (XREF_FIG) and p65 (XREF_FIG)."

25623956

2-hydroxy-17beta-estradiol affects JUN

| 1

2-hydroxy-17beta-estradiol inhibits JUN. 1 / 1

| 1

---

➶

reach

"Chronic ECS also blocked the induction of c-jun in response to an acute, test seizure."

2110970

2-hydroxy-17beta-estradiol affects JAK1

| 1

2-hydroxy-17beta-estradiol inhibits JAK1. 1 / 1

| 1

---

➶

reach

"In agreement with the above results, when the differentiated ECs were treated with inhibitors to block the JAK-1 and STAT3 pathways, QKI-5 did not activate the EC markers CD31, CD144, eNOS, FLK-1 (VEGFR2), and VEGFA (Supporting Information Fig."

28207177

2-hydroxy-17beta-estradiol affects IFNB1

| 1

2-hydroxy-17beta-estradiol inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"The HSV-2 VHS protein inhibits TLR3 and RIG-I/Mda-5 as well as TLR2-mediated antiviral pathways for sensing dsRNA and effectively suppresses IFN-β antiviral responses in human vaginal epithelial cells (ECs) [93]."

32430029

2-hydroxy-17beta-estradiol affects FOS

| 1

2-hydroxy-17beta-estradiol inhibits FOS. 1 / 1

| 1

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➶

reach

"Because levels of Fos protein remain elevated 4 h after a single seizure this finding suggests that the mechanisms by which acute (4 h) and chronic (8-10 days) ECS block the induction of c-fos may differ."

2110970

2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide affects MAPK8

1 |

2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide inhibits MAPK8. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine affects MAPK14

1 |

2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

2-deoxy-D-glucopyranose affects RIPK1

| 1

2-deoxy-D-glucopyranose inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"Down-regulation of RIP1 by 2-deoxy-D-glucose sensitizes breast cancer cells to TRAIL induced apoptosis."

23499682

2-cyclopenten-1-one affects RELA

| 1

2-cyclopenten-1-one inhibits RELA. 1 / 1

| 1

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➶

reach

"Thus, the net effect of PGJ 2 in vivo is to reduce p65 mediated signaling by retaining it in the cytoplasm."

23284631

2-arachidonoylglycerol affects ITCH

| 1

2-arachidonoylglycerol inhibits ITCH. 1 / 1

| 1

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➶

reach

"Both AM251 and AM630 completely reversed the antipruritic effect of pretreatment with JZL184, indicating that the presumed increase in levels of 2-AG in the skin suppresses itch via both CB 1 and CB 2 receptors."

22683515

2-aminooctadec-4-ene-1,3-diol affects RIPK1

| 1

2-aminooctadec-4-ene-1,3-diol inhibits RIPK1. 1 / 1

| 1

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➶

reach

"Saddoughi et al demonstrated that sphingosine analogue drug FTY720 induced necroptosis in lung cancer cells, which was inhibited by necrostatin-1, and knockdown or genetic loss of RIP-1 XREF_BIBR."

23840441

2-aminoethoxydiphenylborane affects PYCARD

| 1

2-aminoethoxydiphenylborane inhibits PYCARD. 1 / 1

| 1

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➶

reach

"Consistent with previous findings XREF_BIBR, XREF_BIBR, we observed that 2-APB completely suppressed total IL-1beta release (XREF_FIG), extracellular accumulation of p20 caspase-1 subunit and p17 mature IL-1beta (XREF_FIG), formation of ASC oligomers (XREF_FIG), and induction of propidium 2+ influx (XREF_FIG) in response to nigericin."

25762778

2-aminoadipic acid affects ITCH

| 1

2-aminoadipic acid inhibits ITCH. 1 / 1

| 1

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➶

reach

"Intrathecal injection of astroglial inhibitor L-alpha-aminoadipate reduced AEW induced chronic itch and alloknesis without affecting acute itch."

26645545

2-amino-6-[2-(cyclopropylmethoxy)-6-oxo-1-cyclohexa-2,4-dienylidene]-4-(4-piperidinyl)-1H-pyridine-3-carbonitrile affects IKBKB

1 |

2-amino-6-[2-(cyclopropylmethoxy)-6-oxo-1-cyclohexa-2,4-dienylidene]-4-(4-piperidinyl)-1H-pyridine-3-carbonitrile inhibits IKBKB. 1 / 1

1 |

---

➶

tas

No evidence text available

15225718

2-amino-6-[2-(cyclopropylmethoxy)-6-oxo-1-cyclohexa-2,4-dienylidene]-4-(4-piperidinyl)-1H-pyridine-3-carbonitrile affects CHUK

1 |

2-amino-6-[2-(cyclopropylmethoxy)-6-oxo-1-cyclohexa-2,4-dienylidene]-4-(4-piperidinyl)-1H-pyridine-3-carbonitrile inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

15225718

2-amino-2-deoxy-D-glucopyranose affects RELA

1 |

2-amino-2-deoxy-D-glucopyranose inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

20737476

2-amino-2-deoxy-D-glucopyranose affects NFKB1

1 |

2-amino-2-deoxy-D-glucopyranose inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

20737476

2-amino-2-deoxy-D-glucopyranose affects CHUK

1 |

2-amino-2-deoxy-D-glucopyranose inhibits CHUK. 1 / 1

1 |

---

➶

ctd

No evidence text available

20113495

2-[[5-chloro-2-[2-methoxy-4-(4-morpholinyl)anilino]-4-pyrimidinyl]amino]-N-methylbenzamide affects MAPK8

1 |

2-[[5-chloro-2-[2-methoxy-4-(4-morpholinyl)anilino]-4-pyrimidinyl]amino]-N-methylbenzamide inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamide affects MAP3K7

1 |

2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamide inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]-3-azetidinyl]acetonitrile affects STAT1

| 1

2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]-3-azetidinyl]acetonitrile inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Although baricitinib completely inhibited the IFN stimulated activation of STAT1, the effects on DCs were partial; baricitinib has almost no inhibitory effect on Tyk2, allowing persistent activity of the Tyk2 pathway for IRF7."

30002661

2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE affects MAPK8

1 |

2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE inhibits MAPK8. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

2-(carbamoylamino)-5-(4-fluorophenyl)-3-thiophenecarboxamide affects TYK2

| 1

2-(carbamoylamino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits TYK2. 1 / 1

| 1

---

➶

sparser

"It should be also noted that, although the inhibition of JAK1 kinase activity alone can explain our results, we cannot rule out the possibility that TPCA-1 also inhibits TYK2, a kinase very similar to JAK1 and generally a target for the same inhibitors affecting JAK1 (51–53)."

26331681

2-(carbamoylamino)-5-(4-fluorophenyl)-3-thiophenecarboxamide affects RELA

| 1

2-(carbamoylamino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits RELA. 1 / 1

| 1

---

➶

reach

"Further, while the IKKbeta inhibitor TPCA-1 inhibited p65 activation, knockdown of TRAF3IP2 blunted both IKKbeta kinase activity and p65 phosphorylation."

26148936

2-(carbamoylamino)-5-(4-fluorophenyl)-3-thiophenecarboxamide affects MYD88

| 1

2-(carbamoylamino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Furthermore, we detected peak phospho-SNAP23 (on Ser 95) in phagosomal lysates at 90 min post phagocytosis of beads and LPS by WT DC (XREF_FIG), and this was reduced in Triotaf -/- Myd88 -/- and WT DC treated with the IKK2 inhibitor TPCA-1 (XREF_FIG)."

25083866

2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE affects MAPK14

1 |

2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranone affects TRAF6

| 1

2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranone inhibits TRAF6. 1 / 1

| 1

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➶

reach

"Thus, we first analyzed PSC27 cell lysates by phosphorylated ATM (p-ATM)-based immunoprecipitation (IP) shortly after bleomycin treatment, and found a physical interaction between activated ATM and TRAF6, albeit diminished by an ATM inhibitor KU55933."

29712904

2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile affects NLRP3

| 1

2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Verapamil inhibits activation of NLRP3 inflammasome and hepatic metaflammation in HF diet fed mice."

30429827

2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) affects STAT1

| 1

2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Luteolin blocked NF-kappaB signaling through inhibition of nuclear translocation and DNA binding activity of NF-kappaB p50 subunit and suppressed STAT1 signaling."

21309717

2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) affects MAPK8

| 1

2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"Luteolin inhibits JNK1 and p90RSK activities, but not JNK2 and ERK2 activities in vitro."

23551430

2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) affects IRF3

| 1

2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Luteolin suppressed activation of Interferon regulatory factor 3 (IRF3) and NFkappaB induced by TLR3 and TLR4 agonists resulting in the decreased expression of target genes such as TNF-alpha, IL-6, IL-12, IP-10, IFNbeta, CXCL9, and IL-27 in macrophages."

19426678

2-(2-amino-3-methoxyphenyl)chromen-4-one affects STAT1

| 1

2-(2-amino-3-methoxyphenyl)chromen-4-one inhibits STAT1. 1 / 1

| 1

---

➶

medscan

"Inhibitors of STAT1, mitogen activated protein kinase kinase (MEK) (PD98059), and phosphatidyl inositol 3 kinase (LY294002), blocked gp120-induced STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120-induced monocyte adhesion and migration across in vitro blood-brain barrier models. 4999998={CellProcess=4116477 CellType=10000095}}"

19103208

2-(2-amino-3-methoxyphenyl)chromen-4-one affects NFKBIA

| 1

2-(2-amino-3-methoxyphenyl)chromen-4-one inhibits NFKBIA. 1 / 1

| 1

---

➶

medscan

"The OPN-mediated increases in IKK alpha/beta, IkappaBalpha and p65 Ser(536) phosphorylation were inhibited by Ly294002, Akt inhibitor and PD98059. 32999999="S536"}"

18996613

2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE affects MAPK14

1 |

2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

2,6-dimethylpyridine affects PYCARD

| 1

2,6-dimethylpyridine inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Lut significantly suppressed P2X4, NLRP1, ASC, and Caspase-1p10."

25450234

2,6-di-tert-butyl-4-methylphenol affects RELA

1 |

2,6-di-tert-butyl-4-methylphenol inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

16478757

2,6-di-tert-butyl-4-methylphenol affects NFKBIA

| 1

2,6-di-tert-butyl-4-methylphenol inhibits NFKBIA. 1 / 1

| 1

---

➶

eidos

"However , data from our results showed that BHT could not inhibit activation of NF-kappaB and degradation of Ikappa-B-alpha ."

32397290

2,5-diphenylfuran affects MYD88

| 1

2,5-diphenylfuran inhibits MYD88. 1 / 1

| 1

---

➶

sparser

"In this study, we found that PPF inhibited LPS-induced MyD88, TRAF6, TRIF expression and IRF3 and p38-MAPK phosphorylation in neutrophils in a concentration-dependent manner."

25446563

2,4-dinitrobenzenesulfonic acid affects PYCARD

| 1

2,4-dinitrobenzenesulfonic acid inhibits PYCARD. 1 / 1

| 1

---

➶

reach

"Weight loss and macroscopic damage in Pycard -/- and Nlrp3 -/- mice were similar to wild-type mice treated with DNBS (XREF_FIG)."

22426419

2,4-dinitrobenzenesulfonic acid affects NLRP3

| 1

2,4-dinitrobenzenesulfonic acid inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Weight loss and macroscopic damage in Pycard -/- and Nlrp3 -/- mice were similar to wild-type mice treated with DNBS (XREF_FIG)."

22426419

2,4,6-trinitrobenzenesulfonic acid affects STAT1

| 1

2,4,6-trinitrobenzenesulfonic acid inhibits STAT1. 1 / 1

| 1

---

➶

reach

"Paeonol attenuates TNBS induced colitis by inhibiting NF-kappaB and STAT1 transactivation."

16928387

2,4,6-trinitrobenzenesulfonic acid affects RELA

| 1

2,4,6-trinitrobenzenesulfonic acid inhibits RELA. 1 / 1

| 1

---

➶

reach

"In conclusion, the present study demonstrated that EEN attenuated DSS- and TNBS induced colitis by inhibiting p65 activation via regulating the p38 and MSK1 pathway, thus suggesting that EEN is effective in the treatment of colitis."

29901086

2,4,6-trinitrobenzenesulfonic acid affects NLRP3

| 1

2,4,6-trinitrobenzenesulfonic acid inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Norisoboldine, a natural aryl hydrocarbon receptor agonist, alleviates TNBS induced colitis in mice, by inhibiting the activation of NLRP3 inflammasome."

29576052

2,3,7,8-tetrachlorodibenzodioxine affects NFKB1

1 |

2,3,7,8-tetrachlorodibenzodioxine inhibits NFKB1. 1 / 1

1 |

---

➶

ctd

No evidence text available

21097750

2,3,7,8-tetrachlorodibenzodioxine affects JUN

| 1

2,3,7,8-tetrachlorodibenzodioxine inhibits JUN. 1 / 1

| 1

---

➶

reach

"Furthermore, we show that both E-cadherin repression and Jun N-terminal kinases activation by dioxin and AhR also depend on the expression of Nedd9/Hef1/Cas-L."

19648964

2,2,2-trifluoroethanol affects RIPK1

| 1

2,2,2-trifluoroethanol bound to RNAP inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"In the context of the PIC, the binding of TFE to RNAP triggers clamp opening, increases the apparent affinity of RIP for RNAP and enhances its inhibitory effects of RIP on PIC formation and transcription."

28681113

1H-indole-3-carboxylic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester affects FOS

| 1

1H-indole-3-carboxylic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester inhibits FOS. 1 / 1

| 1

---

➶

reach

"Importantly, tropisetron attenuated apomorphine induced increase in c-fos positive cells in the VTA, but not the nucleus accumbens or the dorsolateral striatum [XREF_BIBR]."

23856289

1H-imidazole affects CASP1

| 1

1H-imidazole inhibits CASP1. 1 / 1

| 1

---

➶

reach

"(1993a) Imidazole antimycotics inhibitors of cytochrome P45, increase B. eleioik et al.."

9029372

1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one affects MAPK8

| 1

1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"Interestingly, the sGC inhibitor, ODQ (30muM), potentiated the YC-1-mediated induction of ERK1/2 and JNK1 but had no effect on the activation of p38 MAPK (XREF_FIG), suggesting that YC-1 activates the three arms of MAPK via different signaling pathways."

18923065

1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one affects FOS

| 1

1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits FOS. 1 / 1

| 1

---

➶

reach

"The sGC inhibitor ODQ attenuated the induction of c-Fos, Egr-1, Arc and BDNF following bicuculline (XREF_FIG)."

21562256

17beta-estradiol affects NLRP3

| 1

17beta-estradiol inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Estradiol inhibits NLRP3 inflammasome in fibroblast like synoviocytes activated by lipopolysaccharide and adenosine triphosphate."

29105345

17beta-estradiol affects JUN

| 1

17beta-estradiol inhibits JUN. 1 / 1

| 1

---

➶

reach

"Philips A., Chalbos D. and Rochefort H., Estradiol increases and anti-estrogens antagonize the growth factor induced activa- tor protein-1 activity in MCF7 breast cancer cells without affecting c-fos and c-jun synthesis."

9449240

17beta-estradiol affects FOS

| 1

17beta-estradiol inhibits FOS. 1 / 1

| 1

---

➶

reach

"It has been shown that 17beta-estradiol supplement attenuates stress induced c-fos immunoreactivity in the MeA 34, indicating that estrogen prevents neural activation of MeA neurons during stress."

27091896

17alpha-ethynylestradiol affects MYD88

| 1

17alpha-ethynylestradiol inhibits MYD88. 1 / 1

| 1

---

➶

reach

"Estrogen and progesterone appear to inhibit MyD88, thereby illustrating how clinical and tumor related factors - chemotherapy, MyD88, and estrogen and progesterone - might together plausibly give rise to interactions that modify clinical outcomes."

26780780

17alpha-ethynylestradiol affects FOS

| 1

17alpha-ethynylestradiol inhibits FOS. 1 / 1

| 1

---

➶

reach

"In addition, Estrogen inhibits c-Fos activity during RANKL induced osteoclastogenesis [XREF_BIBR]."

23238785

17(18)-EpETE affects NFKBIA

| 1

17(18)-EpETE inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"The inhibition of peroxisome proliferator activated receptor (PPAR) gamma by GW9662 abolished 17,18-EpETE + AUDA mediated anti-inflammatory effects by inducing IkappaBalpha degradation and cytokine synthesis, indicating that PPARgamma is a molecular target of epoxy-eicosanoids."

20008283

15-oxo-ETE affects NFKBIA

1 |

15-oxo-ETE inhibits NFKBIA. 1 / 1

1 |

---

➶

ctd

No evidence text available

25450232

15-oxo-ETE affects IKBKB

1 |

15-oxo-ETE inhibits IKBKB. 1 / 1

1 |

---

➶

ctd

No evidence text available

25450232

15-deoxy-Delta(12,14)-prostaglandin J2 affects STAT1

| 1

15-deoxy-Delta(12,14)-prostaglandin J2 inhibits STAT1. 1 / 1

| 1

---

➶

reach

"15d-PGJ2 blocked IL-10-induced STAT1 and STAT3 activation in primary human monocytes, macrophages and THP-1 cells."

15840591

15-deoxy-Delta(12,14)-prostaglandin J2 affects RELA

| 1

15-deoxy-Delta(12,14)-prostaglandin J2 inhibits RELA. 1 / 1

| 1

---

➶

reach

"Transient transfection with IKKalpha significantly induced p65 transcriptional activity which was completely blocked by 15d-PGJ2 treatment suggesting that 15d-PGJ2 inhibits NF-kappaB function by inhibiting IKKalpha activity in bEND.3 cells."

18691416

15-deoxy-Delta(12,14)-prostaglandin J2 affects NLRP3

| 1

15-deoxy-Delta(12,14)-prostaglandin J2 inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes."

25681332

15-deoxy-Delta(12,14)-prostaglandin J2 affects CHUK

| 1

15-deoxy-Delta(12,14)-prostaglandin J2 inhibits CHUK. 1 / 1

| 1

---

➶

reach

"Moreover, recent studies have also shown that 15d-PGJ2 can directly inhibit Ikappa-B kinase and DNA binding of NF-kappaB in macrophages [36,39], these results have probably provided a mechanism for our observation that 15d-PGJ2 upregulates the expression of IL-8 gene by inhibition of NF-kappaB signaling pathway.The findings of the current studies provide evidence for the first time that 15d-PGJ2 can up-regulate IL-8 gene expression in THP-1 macrophages, and the 15d-PGJ2-mediated IL-8 upregulation is related to MAPK and NF-kappaB signaling pathways."

11755918

14,15-EET affects JUN

| 1

14,15-EET inhibits JUN. 1 / 1

| 1

---

➶

reach

"In this study, we found that 14,15-EET reduced c-jun and JNK activation in CSMC undergoing OGD."

29081082

11,12-EET affects NFKBIA

| 1

11,12-EET inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"These phenomena has been previously reported that 11,12-EET significantly attenuates the TNF-alpha-stimulated endothelial activation and leukocyte adhesion by inhibiting IkappaBalpha degradation and NF-kappaB activation, whereas 14,15-EET results in a lower activation of NF-kappaB [XREF_BIBR]."

26035589

1-phenylethanol affects CASP1

| 1

1-phenylethanol inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Alpha 1-Antitrypsin Does Not Inhibit Human Monocyte Caspase-1."

25658455

1-octadec-9-enoylglycero-3-phosphate affects STAT1

| 1

1-octadec-9-enoylglycero-3-phosphate inhibits STAT1. 1 / 1

| 1

---

➶

medscan

"However, lysophosphatidic acid also inhibits EGF-induced activation of signal transducer and activator of transcription 1 in A431 esophageal squamous cell carcinoma cells ( )."

23467751

1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-3-indazolecarboxamide affects NLRP3

| 1

1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-3-indazolecarboxamide inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Additionally, granisetron could inhibit the activation of p38 MAPK and NLRP3 inflammasome both invivo and invitro."

30551881

1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine affects MAP3K7

1 |

1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

1-cyclopropyl-3-[3-[5-(4-morpholinylmethyl)-2-benzimidazolylidene]-1,2-dihydropyrazol-4-yl]urea affects TYK2

1 |

1-cyclopropyl-3-[3-[5-(4-morpholinylmethyl)-2-benzimidazolylidene]-1,2-dihydropyrazol-4-yl]urea inhibits TYK2. 1 / 1

1 |

---

➶

tas

No evidence text available

19143567

1-chloro-2,4-dinitrobenzene affects NFKBIA

| 1

1-chloro-2,4-dinitrobenzene inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"NiSO (4) but not DNCB was able to activate the degradation of IkappaB-alpha leading to the binding of the p65 subunit of NF-kappaB on specific DNA probes."

17636246

1-[5-t-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-phenylmethoxyethyl)-1,3-thiazol-2-yl]urea affects MAPK14

1 |

1-[5-t-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-phenylmethoxyethyl)-1,3-thiazol-2-yl]urea inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

22154891

1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea affects MAPK14

1 |

1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

1-NM-PP1 affects MAPK8

1 |

1-NM-PP1 inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

17850214

1-NA-PP1 affects MAPK8

1 |

1-NA-PP1 inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

17850214

1-NA-PP1 affects ITCH

| 1

1-NA-PP1 inhibits ITCH. 1 / 1

| 1

---

➶

reach

"For example, previous studies revealed that 4-amino-1-tert-butyl-3-(1 '-naphthyl) pyrazolo [3,4-d] pyrimidine (NA-PP1) specifically inhibits AS kinases but not their appropriate wild-type kinase because its bulkier side chain prevents NA-PP1 from accessing the ATP binding pocket of wild-type kinases [XREF_BIBR, XREF_BIBR]."

26912131

1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE affects CASP1

1 |

1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE inhibits CASP1. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

1,4-dithiothreitol affects MAPK8

1 |

1,4-dithiothreitol inhibits MAPK8. 1 / 1

1 |

---

➶

ctd

No evidence text available

10644709

1,4-dithiothreitol affects JAK1

| 1

1,4-dithiothreitol inhibits JAK1. 1 / 1

| 1

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➶

reach

"Treatment with the oxidant o-IBZ, resulted in a substantial increase in the relative sulfenic acid content of purified recombinant JAK1, as compared to that of JAK1 which was treated with the reducing agent DTT (XREF_FIG)."

22939972

1,4-dithiothreitol affects IRF3

| 1

1,4-dithiothreitol inhibits IRF3. 1 / 1

| 1

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➶

reach

"However, DTT treatment of cells blocked MAVS aggregation as well as IRF3 activation by Sendai virus (XREF_SUPPLEMENTARY)."

21782231

1,4-dithiothreitol affects IKBKG

| 1

1,4-dithiothreitol inhibits IKBKG. 1 / 1

| 1

---

➶

reach

"In contrast, NEMO 1-120 (L107C) was readily reduced by DTT even in the absence of urea."

25400026

1,4-dithiothreitol affects CHUK

1 |

1,4-dithiothreitol inhibits CHUK. 1 / 1

1 |

---

➶

ctd

No evidence text available

17067557

1,4-benzoquinone affects IKBKB

| 1

1,4-benzoquinone inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Celastrol is a quinone methide triterpene inhibiting directly kinases IKKalpha and IKKbeta and inactivates CDC37 (cell division cycle 37) and p23 (prostaglandin E synthase 3) proteins and is thus an HSP90 (heat-shock protein 90 kDa) inhibitor."

26775695

1,4-benzoquinone affects CHUK

| 1

1,4-benzoquinone inhibits CHUK. 1 / 1

| 1

---

➶

reach

"Celastrol is a quinone methide triterpene inhibiting directly kinases IKKalpha and IKKbeta and inactivates CDC37 (cell division cycle 37) and p23 (prostaglandin E synthase 3) proteins and is thus an HSP90 (heat-shock protein 90 kDa) inhibitor."

26775695

1,3,5-trinitrobenzene affects NLRP3

| 1

1,3,5-trinitrobenzene inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"The purpose of this study was to investigate the possibility that side-wall functionalization of TNB could attenuate bioactivity and subsequent NLRP3 inflammasome activation and IL-1beta release."

25179214

1,2-oxazolidine affects JUN

| 1

1,2-oxazolidine inhibits JUN. 1 / 1

| 1

---

➶

reach

"XREF_BIBR In summary, here we have demonstrated that the isoxazolidine transcriptional activation domain mimic 1 requires the KIX domain of CBP for cellular function and, consistent with this mechanism, 1 can competitively inhibit the ability of the native KIX dependent activators Jun and MLL to function."

20882601

1,2-dioleoyl-sn-glycero-3-phospho-L-serine affects NLRP3

| 1

1,2-dioleoyl-sn-glycero-3-phospho-L-serine inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Moreover, DOPS treatment could also markedly suppress the activation of NLRP3 inflammasome and beta-arrestin1 in vivo and in vitro."

29421053

1,2-dichloroethane affects STAT1

| 1

1,2-dichloroethane inhibits STAT1. 1 / 1

| 1

---

➶

reach

"DCE and CS inhibit STAT3 and STAT1 whereas increase EGFR/ERK1/2 phosphorylation."

25226283

1,2-dichloroethane affects RELA

| 1

1,2-dichloroethane inhibits RELA. 1 / 1

| 1

---

➶

reach

"In this cellular model, EDC exposure disrupted p65 and p53 signaling to decrease expression of mitochondrial respiratory genes like CYB5A and POLRMT, and attenuated cellular respiratory capacity."

28794470

1,2-bis(diphenylphosphino)ethane affects RIPK1

| 1

1,2-bis(diphenylphosphino)ethane inhibits RIPK1. 1 / 1

| 1

---

➶

reach

"DPPE, in contrast to DOPE, treatment of the cells impaired the modification of both TNFR1 and RIP, indicating that translocation precedes ubiquitylation and that the addition of ubiquitin takes place within microdomains."

12753742

(aminomethyl)phosphonic acid affects ITCH

| 1

(aminomethyl)phosphonic acid inhibits ITCH. 1 / 1

| 1

---

➶

reach

"Interestingly, glutamate also mediates histamine dependent itch as the scratching responses elicited by histamine are abolished by the AMPA and Kainate antagonist CNQX."

25894692

(aminomethyl)phosphonic acid affects FOS

| 1

(aminomethyl)phosphonic acid inhibits FOS. 1 / 1

| 1

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➶

reach

"C-Fos induction was blocked by TTX but not by AMPA or NMDA receptor antagonists, suggesting that c-Fos upregulation requires action potential firing, but not excitatory synaptic input."

19997631

(Z)-14-methylpentadec-2-enoic acid affects NFKBIA

| 1

(Z)-14-methylpentadec-2-enoic acid inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"The lack of effect of C12 alone in 15 min, together with its more dramatic effect at 2 h in the presence of LPS (relative to resting cells) suggests that C12 blocked the re-synthesis of IkappaBalpha following the rapid LPS stimulated degradation."

23720811

(Z)-14-methylpentadec-2-enoic acid affects JUN

| 1

(Z)-14-methylpentadec-2-enoic acid inhibits JUN. 1 / 1

| 1

---

➶

reach

"We found that C12 treatment of FRT cells for 2 hours produced an ~ 2-fold increase in c-Jun protein; C12 mediated c-Jun increase was not inhibited by TQ416 (XREF_FIG, left)."

23910799

(S)-nicotine affects JUN

1 |

(S)-nicotine inhibits JUN. 1 / 1

1 |

---

➶

ctd

No evidence text available

17003101

(S)-nicotine affects FOS

1 |

(S)-nicotine inhibits FOS. 1 / 1

1 |

---

➶

ctd

No evidence text available

17003101

(S)-naringenin affects NLRP3

| 1

(S)-naringenin inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Naringenin attenuates nonalocholic fatty liver disease by downregulating NLRP3 and NF-kappaB pathway in mice."

31758699

(S)-naringenin affects IRF3

| 1

(S)-naringenin inhibits IRF3. 1 / 1

| 1

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➶

reach

"In our study, naringenin failed to inhibit the activation of IRF3 or attenuate the production of IFN-beta or RANTES."

28004841

(S)-lactic acid affects TRAF3

| 1

(S)-lactic acid inhibits TRAF3. 1 / 1

| 1

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➶

reach

"Whereas TRAF3 is known to bind to NIK and lead to its ubiquitination and proteasomal degradation [XREF_BIBR], we observed that lactic acid also reduced TRAF3 but increased NIK, reflecting activation of the non canonical NF-kappaB pathway in HUVECs (XREF_FIG, lower panels)."

30659163

(S)-lactic acid affects ITCH

| 1

(S)-lactic acid inhibits ITCH. 1 / 1

| 1

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➶

reach

"Lactic acid, a monocarboxylic acid AHA, has been widely used to relieve itch as an ingredient of moisturizers for AD patients XREF_BIBR."

27274633

(R)-rosmarinic acid affects NLRP3

| 1

(R)-rosmarinic acid inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Further study showed that rosmarinic acid suppresses the activation of the NF-kappaB pathway and NLRP3 inflammasome, which may contribute to its anti-inflammatory effects."

29318480

(R)-rosmarinic acid affects IKBKB

| 1

(R)-rosmarinic acid inhibits IKBKB. 1 / 1

| 1

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➶

reach

"Using the NF-kappaB luciferase reporter system, Western blot analysis, and IKK-beta activity assay, we determined that rosmarinic acid inhibits IKK-beta activity in NF-kappaB signaling, which upregulates the expression of CCL11 and CCR3."

16604092

(R)-lipoic acid affects NFKB1

| 1

(R)-lipoic acid inhibits NFKB1. 1 / 1

| 1

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➶

reach

"In recent work from our laboratory, lipoic acid in the medium of Jurkat cells prevented the activation of NF-KB by TNF-a [13]."

8204089

(R)-carnitine affects RELA

| 1

(R)-carnitine inhibits RELA. 1 / 1

| 1

---

➶

eidos

"In a further study , L-carnitine has shown to decrease NF-kappaB p65 expression by suppressing peroxisome proliferator-activated receptor-gamma and alpha ( PPAR-gamma and alpha ) in a CPT I-dependent manner , suggesting that L-carnitine may be involved in liver inflammation and to a lesser extent in the systemic inflammation [ 107 ] ."

32230855

(E,E,E)-geranylgeraniol affects CASP1

| 1

(E,E,E)-geranylgeraniol inhibits CASP1. 1 / 1

| 1

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➶

reach

"This effect of n-BPs could also be mediated via inhibition of the mevalonate pathway as geranylgeraniol, whose formation n-BPs suppress, inhibits Caspase-1 activation."

27888633

(E)-cinnamaldehyde affects CASP1

| 1

(E)-cinnamaldehyde inhibits CASP1. 1 / 1

| 1

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➶

reach

"Endotoxin induced expression of toll like receptor 4 (TLR4), Myeloid differentiation primary response gene 88 (MyD88), myeloid differentiation protein 2 (MD2), Nod like receptor family, pyrin domain containing 3 (NLRP3), apoptosis associated speck like protein containing a caspase-recruitment domain (ASC), and caspase-1 in spleen and mesenteric lymph nodes (MLNs) were inhibited by all tested doses of cinnamaldehyde and linalool (P < 0.05)."

29389558

(E)-4-hydroxynon-2-enal affects NFKBIA

| 1

(E)-4-hydroxynon-2-enal inhibits NFKBIA. 1 / 1

| 1

---

➶

reach

"HNE significantly decreased LPS and IFN stimulated proteolysis of IkappaB-alpha."

11451748

(E)-4-hydroxynon-2-enal affects JUN

| 1

(E)-4-hydroxynon-2-enal inhibits JUN. 1 / 1

| 1

---

➶

reach

"SHP-1 inhibition by 4-hydroxynonenal activates Jun N-terminal kinase and glutamate cysteine ligase."

18276794

(E)-4-hydroxynon-2-enal affects IKBKB

| 1

(E)-4-hydroxynon-2-enal inhibits IKBKB. 1 / 1

| 1

---

➶

reach

"Conversely, 4-HNE inhibits the release of NF-kappaB by modifying Cys 179 of IKK-beta [XREF_BIBR]."

25843657

(E)-4-hydroxynon-2-enal affects CASP1

| 1

(E)-4-hydroxynon-2-enal inhibits CASP1. 1 / 1

| 1

---

➶

reach

"4-Hydroxynonenal inhibits interleukin-1 beta converting enzyme."

9142649

(E)-3-tosylacrylonitrile affects RELA

| 1

(E)-3-tosylacrylonitrile inhibits RELA. 1 / 1

| 1

---

➶

reach

"We also establish that the small molecule BAY-11-7082 causes a dose dependent inhibition of p65 as well as p50TAD dependent transactivation."

26147604

(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoic acid affects IFNB1

| 1

(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoic acid inhibits IFNB1. 1 / 1

| 1

---

➶

reach

"The downregulation of IFNbeta and TNF as well as the control of the induction of CXCL2 and IL8 by Tha virus observed in XREF_FIG was here confirmed."

28000711

(4S)-limonene affects JUN

| 1

(4S)-limonene inhibits JUN. 1 / 1

| 1

---

➶

reach

"D-limonene chemoprevention of hepatocarcinogenesis in AKR mice : inhibition of c-jun and c-myc."

10425313

(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[[(1S)-1-carboxy-2-phenylethyl]amino]-oxomethyl]-1-pyrrolidinyl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid affects MAPK8

| 1

(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[[(1S)-1-carboxy-2-phenylethyl]amino]-oxomethyl]-1-pyrrolidinyl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"Morever, unilateral ureter obstruction activates JNK1 in an AngII dependent manner as demonstrated by the ability of the angiotensin type 1 receptor blocker candesartan to diminish JNK1 activation and to decrease renal fibrosis XREF_BIBR."

19782079

(2S)-1-(1H-indol-3-yl)-3-[[5-(3-methyl-2H-indazol-5-yl)-3-pyridinyl]oxy]-2-propanamine affects CHUK

1 |

(2S)-1-(1H-indol-3-yl)-3-[[5-(3-methyl-2H-indazol-5-yl)-3-pyridinyl]oxy]-2-propanamine inhibits CHUK. 1 / 1

1 |

---

➶

tas

No evidence text available

(2R)-2-\{(1R)-1-hydroxy-15-[2-(20-methoxy-21-methylnonatriacontyl)cyclopropyl]pentadecyl\}hexacosanoic acid affects TLR7

| 1

(2R)-2-\{(1R)-1-hydroxy-15-[2-(20-methoxy-21-methylnonatriacontyl)cyclopropyl]pentadecyl\}hexacosanoic acid inhibits TLR7. 1 / 1

| 1

---

➶

reach

"The present study showed that xinjiaxiangruyin, yinqiaosan, and Gui Zhi Ma Huang Ge Ban Tang could lower the ratio of Th1 and Th2 cells and Th17 and Treg cells in normal and cold environments, as well as in TLR7 -/- mice, but Gui Zhi Ma Huang Ge Ban Tang is better."

29849712

(2R)-2-\{(1R)-1-hydroxy-15-[2-(20-methoxy-21-methylnonatriacontyl)cyclopropyl]pentadecyl\}hexacosanoic acid affects TBK1

| 1

(2R)-2-\{(1R)-1-hydroxy-15-[2-(20-methoxy-21-methylnonatriacontyl)cyclopropyl]pentadecyl\}hexacosanoic acid inhibits TBK1. 1 / 1

| 1

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➶

reach

"Ma et al51 reported that HSV infection inhibited TBK1 activity, which facilitated viral productive infection, indicating that TBK1 is a negative regulator of HSV propagation."

28112176

(2R)-2-\{(1R)-1-hydroxy-15-[2-(20-methoxy-21-methylnonatriacontyl)cyclopropyl]pentadecyl\}hexacosanoic acid affects IRF3

| 1

(2R)-2-\{(1R)-1-hydroxy-15-[2-(20-methoxy-21-methylnonatriacontyl)cyclopropyl]pentadecyl\}hexacosanoic acid inhibits IRF3. 1 / 1

| 1

---

➶

reach

"Chen Z, Rijnbrand R, Jangra RK, Devaraj SG, Qu L, Ma Y, Lemon SM, Li K: Ubiquitination and proteasomal degradation of interferon regulatory factor-3 induced by Npro from a cytopathic bovine viral diarrhea virus."

20538505

(20S)-ginsenoside Rh1 affects JUN

1 |

(20S)-ginsenoside Rh1 inhibits JUN. 1 / 1

1 |

---

➶

ctd

No evidence text available

22855946

(20S)-ginsenoside Rg3 affects NLRP3

| 1

(20S)-ginsenoside Rg3 inhibits NLRP3. 1 / 1

| 1

---

➶

reach

"Ginsenoside Rg3 suppresses the NLRP3 inflammasome activation through inhibition of its assembly."

31914640

(20S)-ginsenoside Rg3 affects MAP3K7

| 1

(20S)-ginsenoside Rg3 inhibits MAP3K7. 1 / 1

| 1

---

➶

reach

"Stimulation of TRAF6 and TAK1 degradation and inhibition of JNK/AP -1 signalling by ginsenoside Rg3 attenuates hepatitis B virus replication."

24004833

(20S)-ginsenoside Rg3 affects CASP1

| 1

(20S)-ginsenoside Rg3 inhibits CASP1. 1 / 1

| 1

---

➶

reach

"Here we show that ginsenoside Rg3 blocks IL-1beta secretion and caspase-1 activation through inhibiting LPS priming and the NLRP3 inflammasome activation in human and mouse macrophages."

31914640

(1R,2S)-tranylcypromine affects FOS

| 1

(1R,2S)-tranylcypromine inhibits FOS. 1 / 1

| 1

---

➶

reach

"In addition, c-fos induction in response to acute restraint stress was down-regulated by chronic, but not acute, administration of tranylcypromine or imipramine, two drugs that nonselectively increase synaptic levels of norepinephrine and serotonin by inhibition of monoamine oxidase or neurotransmitter reuptake, respectively."

7612155

(17S)-17-[2-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl]-1-oxoethyl]-10,13-dimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one affects CASP1

1 |

(17S)-17-[2-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl]-1-oxoethyl]-10,13-dimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one inhibits CASP1. 1 / 1

1 |

---

➶

tas

No evidence text available

27777011

(-)-noscapine affects NFKBIA

| 1

(-)-noscapine inhibits NFKBIA. 1 / 1

| 1

---

➶

medscan

"These results indicate that noscapine inhibits both TNF-induced nuclear factor-kappaB activation and IκBα degradation."

20354190

(-)-epigallocatechin 3-gallate affects MYD88

| 1

(-)-epigallocatechin 3-gallate inhibits MYD88. 1 / 1

| 1

---

➶

reach

"EGCG inhibited the activation of NF-kappaB and the upregulation of TLR 2, 4 and 9 as well as their adaptors MyD88 and TRAF6 in the lungs following PQ challenge."

27890776

(-)-epigallocatechin 3-gallate affects MAPK8

| 1

(-)-epigallocatechin 3-gallate inhibits MAPK8. 1 / 1

| 1

---

➶

medscan

"Furthermore, (-)-Epigallocatechin-3-gallate treatment inhibited TNF-α/JNK signaling and increased the phosphorylation of Akt and glycogen synthase kinase-3β in the hippocampus of APP/PS1 mice."

23660953

(-)-epigallocatechin 3-gallate affects JAK1

| 1

(-)-epigallocatechin 3-gallate inhibits JAK1. 1 / 1

| 1

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➶

reach

"As seen in XREF_FIG and XREF_FIG, EGCG pretreatment sharply abolished the elevation of JAK1, JAK2, p-STAT3, and BNIP3 at all time points, in a dose dependent manner."

26929598

(-)-epigallocatechin 3-gallate affects IFIH1

| 1

(-)-epigallocatechin 3-gallate inhibits IFIH1. 1 / 1

| 1

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➶

reach

"EGCG did inhibit MDA5 with an IC 50 between 1 to 2 microM, similar to the IC 50 of RIG-I (XREF_SUPPLEMENTARY)."

20877565

(-)-epicatechin-3-O-gallate affects DDX58

| 1

(-)-epicatechin-3-O-gallate inhibits DDX58. 1 / 1

| 1

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➶

reach

"In the biochemical ATPase assay, GCG, ECG, CG and TFDG inhibited the shR9 induced RIG-I ATPase activity to similar degree as EGCG (XREF_FIG)."

20877565

(-)-DIHYDROGUAIARETICACID affects JUN

1 |

(-)-DIHYDROGUAIARETICACID inhibits JUN. 1 / 1

1 |

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➶

tas

No evidence text available

24831826

(-)-DIHYDROGUAIARETICACID affects FOS

1 |

(-)-DIHYDROGUAIARETICACID inhibits FOS. 1 / 1

1 |

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➶

tas

No evidence text available

24831826

(+)-sesamin affects MAPK14

| 1

(+)-sesamin inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Sesamin inhibits lipopolysaccharide-induced proliferation and invasion through the p38-MAPK and NF-κB signaling pathways in prostate cancer cells."

25845399

(+)-pilocarpine affects RELA

| 1

(+)-pilocarpine inhibits RELA. 1 / 1

| 1

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➶

reach

"Moreover, pilocarpine induced NF-kappaB p65 activation was partially inhibited by either Akt or ERK inhibitor."

26336823

(+)-pilocarpine affects NFKBIA

| 1

(+)-pilocarpine inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"As shown in Fig. 5 C, pilocarpine alone significantly increased the degradation of IkappaBalpha (relative to control experiments)."

23142559

(+)-pilocarpine affects FOS

| 1

(+)-pilocarpine inhibits FOS. 1 / 1

| 1

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➶

reach

"Pilocarpine induced c-fos was significantly reduced in the frontal cortex and hippocampus by chronic lithium, but was enhanced in the occipital cortex and hypothalamus."

9165496

(+)-catechin affects RELA

| 1

(+)-catechin inhibits RELA. 1 / 1

| 1

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➶

reach

"XREF_BIBR Epigallocatechin-3-gallate (EGCG), a gallic acid ester of catechin, blocks the production of TNF-alpha, IFN-gamma, NF-kB, and p65, which reduces inflammation in the intestinal mucous membrane."

25349576

(+)-artemisinin affects NLRP3

| 1

(+)-artemisinin inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Artemisinin treatment also reduced the neuritic plaque burden and NLRP3 inflammasome activity in an AD transgenic mouse model."

28337127

(+)-alpha-tocopherol affects RELA

| 1

(+)-alpha-tocopherol inhibits RELA. 1 / 1

| 1

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➶

reach

"Moreover, vitamin E deficiency down-regulated antimicrobial peptides (Hepcidin, liver expressed antimicrobial peptide-2A, -2 B, beta-defensin), IL-10, TGFbeta1, IkappaBalpha, TOR and S6K1 mRNA levels (P < 0.05) and up-regulated IL-1beta, IL-6, IL-8, IFN-gamma2 and TNFalpha, NF-kappaB p65, IKKalpha, IKKbeta and 4EBP1 (not in the head kidney) mRNA levels (P < 0.05)."

27888132

(+)-alpha-tocopherol affects NFKBIA

| 1

(+)-alpha-tocopherol inhibits NFKBIA. 1 / 1

| 1

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reach

"PMC, a potent hydrophilic alpha-tocopherol derivative, inhibits NF-kappaB activation via PP2A but not IkappaBalpha dependent signals in vascular smooth muscle cells."

24725826

(+)-alpha-tocopherol affects CHUK

| 1

(+)-alpha-tocopherol inhibits CHUK. 1 / 1

| 1

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➶

reach

"Moreover, vitamin E deficiency down-regulated antimicrobial peptides (Hepcidin, liver expressed antimicrobial peptide-2A, -2 B, beta-defensin), IL-10, TGFbeta1, IkappaBalpha, TOR and S6K1 mRNA levels (P < 0.05) and up-regulated IL-1beta, IL-6, IL-8, IFN-gamma2 and TNFalpha, NF-kappaB p65, IKKalpha, IKKbeta and 4EBP1 (not in the head kidney) mRNA levels (P < 0.05)."

27888132

(+)-Tetrandrine affects RELA

1 |

(+)-Tetrandrine inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

30549224

Uridine 5'-monophosphate affects STAT1

| 1

Uridine 5'-monophosphate inhibits STAT1. 1 / 1

| 1

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➶

reach

"There is a direct correlation in SFFV infected erythroid cells between expression of PU.1 and inhibition of Stat1 DNA binding activity [XREF_BIBR], suggesting that PU.1 expression in erythroid cells may be causing the block in Stat1 activation."

21994618

Uridine 5'-monophosphate affects IRF7

| 1

Uridine 5'-monophosphate inhibits IRF7. 1 / 1

| 1

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➶

reach

"PU.1 suppressed ORF57 activation by inducing IRF7."

28481873

Indirubin-3'-oxime affects MAPK8

| 1

Indirubin-3'-oxime inhibits MAPK8. 1 / 1

| 1

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➶

reach

"Kinase assay showed that indirubin-3 '-oxime directly inhibited the activity of all three isoforms of JNK (JNK1, and JNK3) in vitro, with half inhibition dose (IC50) of 0.8 microM, 1.4 microM, and 1.0 microM, respectively."

15337265

Diphenylmethane-4,4'-diisocyanate affects NFKB1

| 1

Diphenylmethane-4,4'-diisocyanate inhibits NFKB1. 1 / 1

| 1

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➶

reach

"These results indicate the expressions of many proteins that enhance NFkB signaling tended to be downregulated by treatment with pamidronate for 48 h, that is, pAKT1/2/3, GADD45, GADD153, p38, p-p38, SRC1, MDR, and more, proteins suppressing NFkB signaling tended to be upregulated by pamidronate, that is, PTEN, mTOR, PGC-1alpha, and NRF2 (XREF_FIG and XREF_FIG)."

32509464

Cis-3,5,3',4'-tetrahydroxystilbene affects TBK1

1 |

Cis-3,5,3',4'-tetrahydroxystilbene inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

Cis-3,5,3',4'-tetrahydroxystilbene affects IKBKE

1 |

Cis-3,5,3',4'-tetrahydroxystilbene inhibits IKBKE. 1 / 1

1 |

---

➶

tas

No evidence text available

Adenosine 5'-monophosphate affects MAPK8

| 1

Adenosine 5'-monophosphate inhibits MAPK8. 1 / 1

| 1

---

➶

reach

"Cyclin AMP activation also suppressed signaling mediated by thrombin and AA, such as phosphorylation of p38 MAPK, extracellular signal regulated kinase 2, c-Jun N-terminal kinase 1, and Akt [XREF_BIBR, XREF_BIBR]."

28752248

Adenosine 5'-monophosphate affects CHUK

| 1

Adenosine 5'-monophosphate inhibits CHUK. 1 / 1

| 1

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➶

reach

"Nitric Oxide Induced Activation of the AMP Activated Protein Kinase alpha2 Subunit Attenuates IkappaB Kinase Activity and Inflammatory Responses in Endothelial Cells."

21673972

N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide affects MAPK14

1 |

N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide affects TBK1

1 |

N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide inhibits TBK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide affects RIPK1

1 |

N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide inhibits RIPK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide affects MAPK14

1 |

N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide affects MAP3K7

1 |

N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide inhibits MAP3K7. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide affects EIF2AK1

1 |

N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide inhibits EIF2AK1. 1 / 1

1 |

---

➶

tas

No evidence text available

22037378

N-\{2'-[(4-fluorophenyl)amino]-4,4'-bipyridin-2-yl\}-4-methoxycyclohexanecarboxamide affects MAPK8

1 |

N-\{2'-[(4-fluorophenyl)amino]-4,4'-bipyridin-2-yl\}-4-methoxycyclohexanecarboxamide inhibits MAPK8. 1 / 1

1 |

---

➶

tas

No evidence text available

16337120

N-\{2'-[(4-fluorophenyl)amino]-4,4'-bipyridin-2-yl\}-4-methoxycyclohexanecarboxamide affects MAPK14

1 |

N-\{2'-[(4-fluorophenyl)amino]-4,4'-bipyridin-2-yl\}-4-methoxycyclohexanecarboxamide inhibits MAPK14. 1 / 1

1 |

---

➶

tas

No evidence text available

16337120

N-(cyclopropylmethyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide affects MAPK14

1 |

N-(cyclopropylmethyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide affects MAPK14

1 |

N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

N-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREA affects MAPK14

1 |

N-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREA inhibits MAPK14. 1 / 1

1 |

---

➶

drugbank

No evidence text available

10592235

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects RELA

1 |

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

16606632

Bandrowski's base affects MYD88

| 1

Bandrowski's base inhibits MYD88. 1 / 1

| 1

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➶

reach

"The heptameric BB loop peptide competitively inhibits MyD88 homodimerization 20 and ameliorates inflammatory disease in several animal models XREF_BIBR, XREF_BIBR - XREF_BIBR, suggesting that targeting the BB loop is a feasible way to inhibit MyD88 signaling in vivo XREF_BIBR - XREF_BIBR."

29930295

5-aza-2'-deoxycytidine affects STING1

| 1

5-aza-2'-deoxycytidine inhibits STING1. 1 / 1

| 1

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➶

reach

"To evaluate whether loss of cGAS or STING expression involved hypermethylation of the promoter region, A1847 or ES2 cells, which exhibited loss of both cGAS and STING were treated with 5-azadeoxycytidine (5AZADC)."

30587523

5-aza-2'-deoxycytidine affects NFKBIA

| 1

5-aza-2'-deoxycytidine inhibits NFKBIA. 1 / 1

| 1

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➶

reach

"Furthermore, Decitabine markedly reduced phospho-IkappaBalpha and nuclear NF-kappaB-p65, strongly suggesting that Decitabine inhibits activation of the NF-kappaB pathway."

32714333

5,7-dihydroxy-4'-methoxyflavone affects STAT1

| 1

5,7-dihydroxy-4'-methoxyflavone inhibits STAT1. 1 / 1

| 1

---

➶

medscan

"In the present study, we observed that acacetin strongly inhibits activation of Stat-1 and -3 leading to concomitant down-regulation of down-stream targets including VEGF, iNOS, eNOS, bFGF and survivin."

23943785

5,7-dihydroxy-4'-methoxyflavone affects MAPK14

| 1

5,7-dihydroxy-4'-methoxyflavone inhibits MAPK14. 1 / 1

| 1

---

➶

medscan

"Acacetin inhibits the invasion and migration of human non-small cell lung cancer A549 cells by suppressing the p38α MAPK signaling pathway."

21210297

5'-S-methyl-5'-thioadenosine affects NFKB1

| 1

5'-S-methyl-5'-thioadenosine inhibits NFKB1. 1 / 1

| 1

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➶

reach

"Since TLRs and A2 receptors synergize to produce an anti-inflammatory phenotype and both require IRAK4 and TRAF6 signaling XREF_BIBR, it is not surprising that Ado and MTA did not completely inhibit NF-KB responses."

25117662

5'-S-methyl-5'-thioadenosine affects JUN

| 1

5'-S-methyl-5'-thioadenosine inhibits JUN. 1 / 1

| 1

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➶

reach

"In addition, MTA induced mineralization was blocked by inhibition of extracellular signal regulated kinase (ERK), p38, and Jun N-terminal kinase (JNK) by using U0126, SB203580, and SP600125, respectively."

23683282

4'-epidoxorubicin affects NLRP3

| 1

4'-epidoxorubicin inhibits NLRP3. 1 / 1

| 1

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➶

reach

"Low-dose epirubicin at non cytotoxic doses downregulated NLRP3 inflammasome components and reduced the release of cleaved caspase-1, bioactive IL-1beta, and TNF-alpha following NLRP3 activation in a dose dependent fashion."

31905600

3,3'-diindolylmethane affects RELA

| 1

3,3'-diindolylmethane inhibits RELA. 1 / 1

| 1

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➶

eidos

"D. DIM ( 40 muM ) could inhibit expressions of EGFR and p-EGFR as well as NF-kappaB p65 and p-p65 ."

| PMC

3,3'-diaminobenzidine affects RIPK1

| 1

3,3'-diaminobenzidine inhibits RIPK1. 1 / 1

| 1

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➶

reach

"Nec-1, DAB, and HS-1371 prevented RIP1 and RIP3 kinase activity, resulting in no detection of p-MLKL."

30237400

3,3',5-triiodo-L-thyronine affects TBK1

| 1

3,3',5-triiodo-L-thyronine inhibits TBK1. 1 / 1

| 1

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➶

reach

"However, prolonged exposure to cold induces hypematraemia and T3 lowers the Na/K ratio."

8377674

3,3',5,5'-tetrabromobisphenol A affects RELA

1 |

3,3',5,5'-tetrabromobisphenol A inhibits RELA. 1 / 1

1 |

---

➶

ctd

No evidence text available

26718265

3,3',4,5'-tetrahydroxystilbene affects IKBKB

1 |

3,3',4,5'-tetrahydroxystilbene inhibits IKBKB. 1 / 1

1 |

---

➶

ctd

No evidence text available

20584749

3,3',4,4',5-pentachlorobiphenyl affects RELA

| 1

3,3',4,4',5-pentachlorobiphenyl inhibits RELA. 1 / 1

| 1

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➶

reach

"Exposure to PCB 126 significantly increased expression of p65 at the transcription level, and the PCB 126 induced p65 mRNA was markedly decreased when cells were pre-treated with EGCG at either 15 or 30 muM (XREF_FIG)."

26878794

3',5'-cyclic AMP affects MAVS

| 1

3',5'-cyclic AMP inhibits MAVS. 1 / 1

| 1

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➶

reach

"At the early phase of infection, cAMP levels are down-regulated, which decreases PKACs activity and promotes VISA activity for efficient induction of downstream antiviral genes."

28934360

3',5'-cyclic AMP affects MAPK8

| 1

3',5'-cyclic AMP inhibits MAPK8. 1 / 1

| 1

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➶

medscan

"We showed that cAMP suppresses TNF-alpha-induced MMP-1 expression via protein kinase A (PKA) pathway. cAMP inhibited TNF-alpha-stimulated ERK and JNK activation, which was shown to have an important role in MMP-1 expression."

20357815

3',5'-cyclic AMP affects JAK1

| 1

3',5'-cyclic AMP inhibits JAK1. 1 / 1

| 1

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➶

reach

"CAMP increasing agents rapidly inhibited activation of JAK1 and its substrate STAT3."

23454584

3',5'-cyclic AMP affects IFNB1

| 1

3',5'-cyclic AMP inhibits IFNB1. 1 / 1

| 1

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➶

reach

"As shown in Fig. 4 B, inhibition of PKA activity by H-89 increased the effect of luteolin on ISRE reporter expression, whereas increasing intracellular cAMP with 8-Br-cAMP further inhibited the effect of luteolin and IFN-beta."

24333668

2,2',4,4',5,5'-hexachlorobiphenyl affects RELA

| 1

2,2',4,4',5,5'-hexachlorobiphenyl inhibits RELA. 1 / 1

| 1

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➶

reach

"PCB 153 and p, p '-DDE can inhibit RelA (inhibition of an inhibitor) via PXR and AR, respectively, and then RelA activates IL-6."

26685285

2'-deoxyadenosine affects IFNB1

| 1

2'-deoxyadenosine inhibits IFNB1. 1 / 1

| 1

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➶

reach

"As compared with respective control groups, an obvious increase of IFN-alpha (XREF_FIG), IL-6 (XREF_FIG), and TNF-alpha (XREF_FIG) concentrations in poly (dA : dT)-transfected U266 cells and a significant reduction of IFN-beta (XREF_FIG), IL-6 (XREF_FIG), and TNF-alpha (XREF_FIG) secretions in T56si-2-transfected RPMI8229 cells were observed, suggesting that TRIM56 overexpression induced the production of inflammatory cytokines."

29214775

2'-deoxyadenosine 5'-monophosphate affects MYD88

| 1

2'-deoxyadenosine 5'-monophosphate inhibits MYD88. 1 / 1

| 1

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➶

reach

"Blocking DAMP induced MyD88 dependent and independent TLR pathways using chemical and genetic methods may provide additional insights into these mechanisms."

23758833

2'-O-methyluridine affects TBK1

| 1

2'-O-methyluridine inhibits TBK1. 1 / 1

| 1

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➶

reach

"(E) The expression levels of IFNβ and IFNλ1 mRNAs in SARS-487 CoV2 infected Calu-3 cells were at low levels at 24 h.p.i., and this induction was inhibited by the 488 pretreatment of 10 uM BX-795, which blocks the TBK1 kinase activity, prior to SARSThe induction of and response to Type I/III IFNs in SARS-CoV2 infected cells could not 492 restrict the viral replication."

| DOI

2'-O-methyluridine affects NFKB1

| 1

2'-O-methyluridine inhibits NFKB1. 1 / 1

| 1

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➶

reach

"300, uM PDTC clearly blocked NF-KB activation."

7986199

1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone affects JUN

| 1

1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone inhibits JUN. 1 / 1

| 1

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➶

reach

"Furthermore, yakuchinone A and yakuchinone B nullified the activation of the activator protein-1 (AP-1) in immortalized mouse fibroblast cells in culture."

10517978