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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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leupeptin affects CTSB
1 | 24
1 | 24
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"Leupeptin and p-chloromercuribenzoate inhibited both cathepsin B and collagenolytic cathepsin in the ciliary body lysosomes."
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"However, interpretation of the results obtained on whole tissue has been complicated by the fact that antipain and leupeptin are potent inhibitors of lyso- somal cathepsin B, as well as the sarcoplasmic CDP (Umezawa, 1976)."
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"During the time that cathepsin B plus L activities in autophagic vacuoles are inhibited by the injection of leupeptin, cytosolic enzymes are being accumulated in autophagic vacuoles suggesting that leupeptin blocks intralysosomal proteolysis, and that cytosolic enzymes are sequestered continuously into autophagosomes."
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"Because cathepsins are the principal lysosomal proteases, we used cathepsin specific inhibitors, such as leupeptin, E-64 and pepstatin, to determine the relative importance of different cathepsins in degrading MT. The study reveals that cathepsin B and/or L is (are) probably the most important enzyme (s) in degrading hepatic MT, because leupeptin, which blocks cathepsin B and L activity, inhibited the degradation of apo-MT by about 80%."
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"Barrett [35] has shown that leupeptin inhibits human cathepsin B1."
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"Livers of non starved rats were perfused cyclically for 2 h in the presence of either 4 x the normal concentration of amino acids (known to suppress proteolysis to basal level), or the same medium together with leupeptin (an inhibitor of cathepsin B, H and L)."
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"Leupeptin has broad protease specificity and may also inhibit cathepsin B; thus we tested the effect that Sm-p80 might have in CD23 cleavage."
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"The thiol proteinases, cathepsin B, H and L, which are known to be inhibited by leupeptin, are apparently involved in initiating digestion of rat 125I-asialoorosomucoid within liver lysosomes."
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"Both the cathepsin B activities were completely inhibited by iodoacetamide and leupeptin, but phenylmethanesulfonyl fluoride and o-phenanthroline were ineffective."
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"Leupeptin and antipain inhibit some other proteases, and thus probably also cathepsin B1, in a competitive way; under our incubation conditions their inhibition was, however, practically complete."
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"The extent of inactivation of cathepsin B by leupeptin and E-64 significantly decreased in the presence of SA."
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"Dose dependent effects on the embryo were demonstrated using the acid bisazo dye Trypan Blue, which inhibits endocytosis, and an enzyme inhibitor of bacterial origin known as leupeptin which inhibits cathepsin B, H and L. Homogenates of rat kidney and placenta also produced congenital defects; the concommitant electron microscopical changes in the yolk sac suggest that these effects too are due to alterations in the availability or quality of histiotroph."
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"Leupeptin and E-64 dose dependently inhibited both cathepsin B and cathepsin L activities, and pepstatin A strongly inhibited cathepsin D activity in rat kidney lysosomes."
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"Leupeptin is a potent inhibitor of cathepsin B in vitro and is presumed to act in a similar manner in vivo."
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"Leupeptin is a reversible inhibitor of cathepsin B (IC 50% 1 mumol)."
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"The neutral proteinase and cathepsin B like activity were inhibited by leupeptin and not by pepstatin while the converse obtained for cathepsin D activity."
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"When cathepsin D was inhibited by pepstatin, the proteolysis of 125I labeled low density lipoproteins was inhibited by more than 90%, whereas when cathepsin B was inhibited by leupeptin, the rate of proteolysis decreased by approx."
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"For example, leupeptin inhibits trypsin, plasmin, thrombokinase, cathepsin B, and papain; chymostatin inhibits chymotrypsin; and elastatinal inhibits elastase."
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"Injection of leupeptin or E-64 into rats actually inhibits the activities of cathepsin B and cathepsin L in the lysosomal fraction of liver and results in inhibition of turnover rate of liver aldolase (11, 20)."
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"It was strongly inhibited by HgCl2, ZnSO4, iodoacetate, iodoacetamide, and N-ethylmaleimide which indicated that it is a thiol protease, and by leupeptin, a strong inhibitor of cathepsin B from other sources."
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"The comparison of Ki suggested that CA074 and Z-Phe-Phe-FMK inhibited exopeptidase activity, and leupeptin inhibited the endopeptidase activity of cathepsin B more strongly."
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"Both the proteinase and cytotoxic activities of the purified amoebal cathepsin B were inhibited by leupeptin and serum and activated by free sulfhydryl groups, supporting the hypothesis that both activities are characteristics of amoebal cathepsin B. Virulent strains of E. histolytica (HM-1 and Rahman) had significantly more cathepsin B activity per milligram protein than less virulent strains (HK-9, Laredo, and Huff)."
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"Since homogenates of leupeptin treated muscles had decreased cathepsin B activity, this lysosomal protease may play a role in protein turnover in normal and diseased muscles."
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"Administration of leupeptin abolished the increased activity of two intracellular proteases calpain and cathepsin B induced by controlled mechanical ventilation."
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL191881"
simvastatin affects CTSB
| 7
| 7
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"By contrast, E64 and pepstatin A, which are known inhibitors of cathepsin B and cathepsin D, markedly inhibited the activities of cathepsin B and cathepsin D."
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"Both CA-074 (a specific inhibitor of cathepsin B) and pepstatin A (a specific inhibitor of cathepsin D) showed an inhibitory effect on the IL-2 production from an OVA specific, I-Ad- restricted helper T (Th) cell clone upon stimulation with OVA presented by the I-Ad-positive APC."
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"A plausible expla- nation is that pepstatin A inhibits an esterolytic activity of cathepsin B or of a contaminating esterase."
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"There was also a tendency of reduced cathepsin B activity caused by increasing simvastatin concentration (data not shown)."
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"Treatment with E-64 or CA074Me (2 specific inhibitors of cathepsin B) or with pepstatin A (a specific inhibitor of cathepsin D) was cytotoxic for 2 neuroblastoma cell lines having different degrees of malignancy."
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"Since cathepsin B and D are functionally related [XREF_BIBR - XREF_BIBR], THP-1 cells were pre-incubated with combined CA-074Me and pepstatin A (50muM or 100muM of each) for one hour to inhibit cathepsin B and D simultaneously or with 5muM of z-LLY-fmk to inhibit cathepsin L, and then stimulated with 50ng/mL IL-32gamma and infected with MTB H37Rv [XREF_BIBR - XREF_BIBR]."
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"The neutral proteinase and cathepsin B like activity were inhibited by leupeptin and not by pepstatin while the converse obtained for cathepsin D activity."
ethanol affects CTSB
| 1 5
ethanol inhibits CTSB. 6 / 6
| 1 5
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"Gallic acid especially at 200 mg/kg improved ethanol mediated pancreatic tissue damage.In conclusion, gallic acid treatments were decreased release of lysosomal cathepsin B and L enzymes into cytoplasmic fraction and prevented alcohol mediated pancreatic tissue injury."
sparser
"Though ethanol inhibited neither cathepsin B, cathepsin D, nor chymotrypsin-like activity, it did significantly reduce calpain I expression and activity."
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"In line with the above described studies with acridine orange, ethanol inhibited the cholesterol crystal induced leakage of cathepsin B into the cytoplasm."
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"In the present study ethanol significantly reduced the cholesterol crystal induced secretion of IL-1beta, and moreover, ethanol also inhibited lysosomal disruption, and the release of cathepsin B (XREF_FIG)."
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"Our findings suggest that ethanol consumption impaired the biosynthesis of cathepsin B, as indicated by lower quantities and activities of this protease in both post-nuclear and lysosome fractions of ethanol fed rats."
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"Although neither cathepsin B, cathepsin D nor chymotrypsin like activity were inhibited by ethanol (data not shown), ethanol did reduce calpain activity consistent with the finding that ethanol inhibits calpain activity in PC12 cells [XREF_BIBR]."
| 2 4
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"We showed that DPPE 1.1 inhibited the high cathepsin B activity expressed in L. (L.) amazonensis amastigotes."
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"The cathepsin B activity of L. (L.) amazonensis amastigotes was inhibited by DPPE 1.1 as demonstrated spectrofluorometrically by use of a specific fluorogenic substrate."
sparser
"The calculated IC50 values for DPPE 1.2 and CA074 were not significantly different (2.25±0.11 µM and 0.7±0.08 µM, respectively), strongly suggesting that DPPE 1.2 inhibits L. (L.) amazonensis cathepsin B."
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"Since we have shown here that DPPE 1.2 inhibits parasite cathepsin B, killing of L. (L.) amazonensis in infected mice treated with the drug may be associated to protective responses arising from lower expression of the active form of TGF-beta."
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"DPPE 1.1 Inhibits the Cathepsin B Activity of L. (L.) amazonensis Amastigotes."
sparser
"Since we have shown here that DPPE 1.2 inhibits parasite cathepsin B, killing of L. (L.) amazonensis in infected mice treated with the drug may be associated to protective responses arising from lower expression of the active form of TGF-β."
pyridoxine affects CTSB
| 4
| 4
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"We reported that pyridoxal phosphate (PAP), a coenzyme form of vitamin B6, strongly inhibits activities of cathepsin B and weakly inhibits those of cathepsins S, K, and C in vitro."
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"Supplementation of pyridoxine to the maturation medium significantly decreased the activity of CTSB in both bovine cumulus cells and oocytes."
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"We found that pyridoxal phosphate (PAP), a coenzyme form of vitamin B6, inhibits the activities of cathepsin B and L in vitro and vitamin B6 administration induces the inhibition of the lysosomal cathepsin activities in vivo."
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"Therefore, we conclude that ovalbumin dependent antibody productions (IgG1, IgE) were suppressed by pyridoxine excess diet (6 mg%), because hepatic cathepsin B activity was suppressed by the excess pyridoxine in diet."
| 4
Cyclosporin A inhibits CTSB. 4 / 4
| 4
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"Long-term cyclosporin A exposure suppresses cathepsin-B and -L activity in gingival fibroblasts."
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"We have previously reported that CsA impairs the activity of the lysosomal enzymes cathepsin B and L in human gingival fibroblasts (HGFs)."
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"We reported previously that lysosomal protease cathepsin-L activity, but not cathepsin-B, was significantly suppressed by short-term cyclosporin A exposure in human gingival fibroblasts."
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"We have confirmed that CsA down-regulates cathepsin B and L synthesis."
chloroquine affects CTSB
| 4
| 4
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"In addition, chloroquine has been shown to inhibit specifically cathepsin B1 (10), a lysosomal protease capable of degrading collagen (18)."
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"The weak base chloroquine accumulates within acidic intracellular compartments, raises their pH, and can inhibit proteolysis as well as cathepsin B."
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"Chloroquine, at concentrations attained inside the lysosomes, inhibited cathepsin B 1 but not cathepsin D."
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"As the NLRP3 inflammasome can be activated due to lysosomal damage and release of cathepsin B, ammonium chloride (NH 4 Cl) and chloroquine diphosphate (CQ), which inhibit endosomal-lysosomal system acidification, and CA-074-Me, which acts as a cell-permeable inhibitor of thiol proteases, were used to block lysosomal acidification and cathepsin B activity, respectively."
| 3
Pyridoxal 5'-phosphate inhibits CTSB. 3 / 3
| 3
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"We found that pyridoxal phosphate (PAP), a coenzyme form of vitamin B 6, inhibits the activities of cathepsin B and L in vitro and vitamin B 6 administration induces the inhibition of the lysosomal cathepsin activities in vivo."
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"We reported that pyridoxal phosphate (PAP), a coenzyme form of vitamin B6, strongly inhibits activities of cathepsin B and weakly inhibits those of cathepsins S, K, and C in vitro."
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"Furthermore, in vitro, pyridoxal phosphate, a coenzyme form of vitamin B 6, strongly inhibits Cathepsin B activity and weakly inhibits Cathepsin S and K activities XREF_BIBR."
ketone affects CTSB
| 3
ketone inhibits CTSB. 3 / 3
| 3
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"Krantz et al. observed that the second-order rate of inactivation ( k on ) of cathepsin B by acyloxymethyl ketones can increase dramatically when the peptide portion of the inhibitor increases in length and specificity. [3] In the case of bimodal inhibitors of caspase-1, k on (which is equal to k i / K i when [I]≪ K i ) also increases dramatically with improvements in the peptidic (or mimetic) portion of the molecule (data not shown)."
sparser
"Moreover, like substituted benzoates they have low p values (p value of HOBt is 4.3), which has been postulated to correlate the rate of inactivation of cathepsin B by peptidyl acyloxymethyl ketones."
sparser
"SHAW, Inactivation of Cathepsin B1 by diazomethyl ketones."
gallic acid affects CTSB
| 3
Gallic acid inhibits CTSB. 3 / 3
| 3
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"Cathepsin B activities in the cytosolic fraction were decreased by gallic acid (200 mg/kg) and increased in ethanol given rats."
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"Gallic acid treatments decreased release of lysosomal cathepsin B and L enzymes into cytoplasmic fraction and prevented alcohol mediated pancreatic tissue injury."
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"Gallic acid especially at 200 mg/kg improved ethanol mediated pancreatic tissue damage.In conclusion, gallic acid treatments were decreased release of lysosomal cathepsin B and L enzymes into cytoplasmic fraction and prevented alcohol mediated pancreatic tissue injury."
auranofin affects CTSB
| 3
| 3
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"Auranofin inhibits cathepsin B and was previously suggested as a glioblastoma treatment adjunct on that basis [XREF_BIBR]."
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"We have previously shown that analogs of auranofin, a clinically available antiarthritic drug, inhibit cathepsin B."
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"Auranofin also inhibits mitochondrial thioredoxin reductase (TrxR) [XREF_BIBR] and cathepsin B [XREF_BIBR]."
aldehyde affects CTSB
| 3
| 3
sparser
"A structurally homologous peptide aldehyde (ALLM), which inhibits cathepsin B and calpain but is a much weaker inhibitor of the proteasome, did not block transmigration."
sparser
"In contrast to their very different activities against the proteasome, the three pep- tide aldehydes inhibited calpain and cathepsin B with simi- lar potencies (K, values, 5-12 nM)."
sparser
"Regarding the inhibitory potency of the tripeptide aldehyde when covalently linked to 13-cyclodextrin, it showed the same reversible slow-binding inhibition of cathepsin B and Ix-caP pain as Ac-Leu-Leu-Nle-H. Under the experimental condi- tions used the inhibition of cathepsin B by both tripeptide aldehydes follows a simple single-step mechanism A [28], whereas the inhibition of calpain by both inhibitors was de- scribed best by the mechanism B [28] where a rapidly formed initial complex (Ki) is slowly converted to a tightened complex (Ki*)."
1 | 2
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"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL64925"
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"Surprisingly, MG132 also blocked cathepsin B, and at concentrations that were even lower than those required for blocking cathepsin C (XREF_FIG), indicating that MG132 blocks a wide range of proteases."
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"We found that MG132 caused an 80% inhibition of Cathepsin B, whereas lactacystin only slightly (< 10%) inhibited Cathepsin B. Therefore, the strong inhibitory effect of MG132 on degradation of EGF can be explained by the inhibitory effect of MG132 on Cathepsin B."
sulfate affects CTSB
| 2
sulfate inhibits CTSB. 2 / 2
| 2
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"Utilising the ability of CpsB to dephosphorylate pNPP, we performed a screen of a marine extract library culminating in the discovery of a novel meroterpene sulphate, FQE, which inhibited CpsB phosphatase activity with an IC 50 of 5.21 microM."
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"The synthetic protease inhibitor bis [ethyl (2R,3 R)-3-[(S)-methyl-1-[4-(2,3,4-tri-methoxyphenyl-methyl) piperazine-1-ylcarbonyl] butyl-carbonyl] oxiran-2-carboxylate] sulfate (NCO-700) suppressed both activities of calcium activated neutral protease and cathepsin B isolated from cardiac muscle, showing 50% inhibition at 46 and 0.8 mumol/l, respectively."
| 2
Silicon dioxide inhibits CTSB. 2 / 2
| 2
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"For example, silica crystals and aluminum salts have been shown to disrupt lysosomes and release cathepsin B, activating inflammasomes that function as sensors of lysosomal damage."
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"[XREF_BIBR] This is because surface modification of silica nanoparticles reduced ROS production, lysosomal damage, and cathepsin B release."
| 2
Prostaglandin E2 inhibits CTSB. 2 / 2
| 2
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"Prostaglandin E2, but not E1, prevented hyperamylasemia, congestion of amylase and trypsinogen in the acinar cells, redistribution of cathepsin B, and amylase and lactate dehydrogenase discharge from the dispersed acini."
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"Prostaglandin E2, but not E1, prevented the redistribution of cathepsin B along with the hyperamylasemia, and the increase in amylase and trypsinogen in the acinar cells in almost a dose dependent manner, particularly at a dose of 100 micrograms/kg."
methyl affects CTSB
| 2
methyl inhibits CTSB. 2 / 2
| 2
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"In vivo inhibition of cathepsin B by peptidyl (acyloxy) methyl ketones."
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"This is in contrast to bovine cathepsin B and human cathepsin L where both are more readily inhibited by the methyl, rather than the ethyl ester peptide."
gold atom affects CTSB
| 2
Gold atom inhibits CTSB. 2 / 2
| 2
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"Even as little as 15 microg Au mL -1 of NBP and TiO 2 nanostructures significantly reduced the production of mature CTSB."
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"Inhibition of cathepsin B by Au (I) complexes : a kinetic and computational study."
ester affects CTSB
| 2
ester inhibits CTSB. 2 / 2
| 2
sparser
"Cathepsin C, another cysteine proteinase with a rather different substrate specificity (i.e., aminopeptidase), was not inactivated by 8, indicating that the inactivation of papain and cathepsin B by azapeptide esters is a specific process."
sparser
"This is in contrast to related azapeptide esters which inactivate papain and cathepsin B not only rapidly but also completely and essentially irreversibly."
| 1 1
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"Corre- spondingly, purified reduced cathepsin B was inactivated by DHA and reactivated by DTT."
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"Corre- spondingly, purified reduced cathepsin B was inactivated by DHA and reactivated by DTT."
| 2
| 2
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"Thus, as previously described [25], cycloheximide alone decreased the activity of cathepsin B to 20% of the control values."
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"Cycloheximide induced inhibition of cathepsin B activity in rat skeletal muscle."
choline affects CTSB
| 2
choline inhibits CTSB. 2 / 2
| 2
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"In the current study, optimum dietary choline supplementation decreased cathepsin B and L activities (XREF_TABLE)."
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"Correlation analysis indicated that muscle shear force was negatively related to cathepsin B (r = -0.964, P < 0.01) and L (r = -0.972, P < 0.01) activities, suggesting that increment of flesh firmness may partly attribute to optimum dietary choline decreased cathepsin B and L activities."
cadmium atom affects CTSB
| 2
Cadmium atom inhibits CTSB. 2 / 2
| 2
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"58 As shown in XREF_FIG, Cd impaired the maturation of CTSB and CTSD in rPT cells, which was markedly restored by cotreatment with Tre."
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"Consistently, Cd exposure impaired the maturation of CTSB and CTSD in rPT cells, which was significantly restored by the addition of Tre."
berberine affects CTSB
| 2
| 2
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"As expected, berberine significantly decreased soluble APPs, intracellular APP, pAPPThr668 and CTFs in a dose dependent manner (XREF_FIG)."
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"CA-074 Me pretreatment showed the same inhibitory effect on berberine induced cathepsin-B and AIF release (XREF_FIG)."
| 2
Aluminium(3+) inhibits CTSB. 2 / 2
| 2
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"For example, silica crystals and aluminum salts have been shown to disrupt lysosomes and release cathepsin B, activating inflammasomes that function as sensors of lysosomal damage."
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"The aluminum particles caused disruption of the phagolysosomes and release of active cathepsin B into the cytoplasm which may be a sufficient signal for NLPR3 activation."
alloxan affects CTSB
| 1 1
alloxan inhibits CTSB. 1 / 1
| 1
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"After inactivation of cathepsin B by alloxan, the proteinase activity can be restored by subsequent DTT [21]."
alloxan inhibits CTSB. 1 / 1
| 1
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"After inactivation of cathepsin B by alloxan, the proteinase activity can be restored by subsequent DTT [21]."
Z-Val-Phe-H affects CTSB
1 | 1
1 | 1
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"MDL-28170 at the concentration we used may also inhibit cathepsin B XREF_BIBR."
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"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL286722"
| 2
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"HNE may also directly inhibit cathepsin B and other lysosomal cysteine proteases by covalently modifying the enzyme active site."
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"Both HNE and MDA inhibited the cysteine proteases cathepsin B and L at a concentration of 1 microM by 88%-94% and this effect was due to HNE and MDA adducts in the active center of these proteases [XREF_BIBR]."
zinc(2+) affects CTSB
| 1
Zinc(2+) inhibits CTSB. 1 / 1
| 1
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"Cathepsin B was 50% inhibited by 1 muM Zn (2+), and is reportedly inhibited by gold agents."
water affects CTSB
| 1
water inhibits CTSB. 1 / 1
| 1
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"Water immersion also prevents the subcellular redistribution of cathepsin B from a lysosome enriched fraction to a heavier, zymogen granule enriched fraction that is known to occur in this model of pancreatitis."
toremifene affects CTSB
| 1
| 1
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"We found that neither clomiphene nor toremifene inhibited the activity of either cathepsin B or cathepsin L (XREF_FIG and XREF_SUPPLEMENTARY)."
thioridazine affects CTSB
| 1
| 1
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"Thioridazine was found to inhibit lysosomal enzyme activities of cathepsin B and acid phosphatase, but not beta-hexosaminidase when cell extracts were treated with the drug."
sunitinib affects CTSB
| 1
| 1
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"We found that sunitinib treatment for 24h triggers incomplete autophagy, impairs cathepsin B activation and stimulates a lysosomal dependent necrosis."
sulforaphane affects CTSB
| 1
| 1
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"The results showed that sulforaphane preferentially inhibited cathepsin B- and caspase-1-dependent NLRP3 inflammasome activation induced by mostly Abeta1-42 monomers, an effect that potently reduced excessive secretion of the proinflammatory cytokine interleukin-1beta (IL-1beta)."
| 1
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"Multilevel blocking of the RAA system significantly increased activity of cathepsin B in homogenates of glomerular in diabetic rats treated with spironolactone (P = 0.02) and in combination with therapy with losartan and enalapril (P = 0.001) compared to the untreated diabetic rats."
| 1
Ruthenium atom inhibits CTSB. 1 / 1
| 1
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"First generation ruthenium dendrimers inhibit Cathepsin-B which may suggest potential antimetastatic properties of these compounds."
rhenium atom affects CTSB
| 1
Rhenium atom inhibits CTSB. 1 / 1
| 1
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"Rhenium inhibitors of cathepsin B (ReO (SYS) X (where Y = S, py; X = Cl, Br, SPhOMe-p)) : Synthesis and mechanism of inhibition."
quercetin affects CTSB
| 1
| 1
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"Subsequently, quercetin not only inhibited the leakage of cathepsin B into cytoplasm but arrested all measured parameters of mitochondrial apoptosis pathway including MMP, the escape of cytochrome C from mitochondria, and caspase-3 activity."
| 1
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"9 Epasinghe et al. 10 demonstrated that PA can inactivate more than 90% of soluble recombinant MMP-2, -8 and -9 and approximately 70%-80% of cysteine cathepsin B and K; these results are significantly better those derived from the use of CHX."
phorbol affects CTSB
| 1
phorbol inhibits CTSB. 1 / 1
| 1
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"The TSH induced increase in cathepsin B mRNA concentrations (approximately fivefold over that in untreated cells) was partially mimicked by forskolin (approximately threefold) and ionomycin, while phorbol ester decreased cathepsin B mRNA concentrations."
| 1
Phenylmethanesulfonyl fluoride inhibits CTSB. 1 / 1
| 1
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"The kinetics was measured in the presence and absence of the inhibitors PMSF, E64, and CA074, which inhibit serine proteases, cysteine proteases, and cathepsin B, respectively."
pazopanib affects CTSB
| 1
| 1
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"By contrast, treatment for 48h with pazopanib induces cathepsin B activation and autophagic cell death, markedly reversed by CA074-Me and 3-MA, cathepsin B and autophagic inhibitors, respectively."
nobelium affects CTSB
| 1
| 1
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"XREF_BIBR, XREF_BIBR No inhibition of cathepsin B was observed."
nifedipine affects CTSB
| 1
| 1
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"A calcium antagonist, nifedipine, specifically suppressed cathepsin-L activity and mRNA expression, but not that of cathepsin-B in cultured gingival fibroblasts."
nicotinamide affects CTSB
| 1
| 1
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"Nicotinamide inhibits the lysosomal cathepsin b like protease and kills African trypanosomes."
methanol affects CTSB
| 1
| 1
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"The acetone extract of S. sempervirens was found to be antifungal towards Candida glabrata (IC50 = 15.98 microg/ml), and both the acetone and MeOH extracts inhibited the proteolytic activity of cathepsin B (IC50 = 4.58 and 5.49 microg/ml, resp.)"
methane affects CTSB
| 1
methane inhibits CTSB. 1 / 1
| 1
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"Analogs of Ep-475 (2a), designed to explore the role played by the carboxylate in epoxysuccinate thiol protease inhibitors, have been synthesized and tested as inhibitors of papain and cathepsin B. Papain and cathepsin B are rapidly inactivated by carboxylates 2a and 6a, but are inactivated much more slowly by 2b-2f, 6c, and 6f, in which the carboxylate is absent or replaced by an amide, ester, or ketone."
| 1
| 1
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"Both HNE and MDA inhibited the cysteine proteases cathepsin B and L at a concentration of 1 microM by 88%-94% and this effect was due to HNE and MDA adducts in the active center of these proteases [XREF_BIBR]."
| 1
Low-density lipoprotein inhibits CTSB. 1 / 1
| 1
sparser
"Thus, the data indicate that HOCl-modified LDL inactivates cathepsin B by a chloramine-dependent mechanism, most likely via oxidation of the enzyme's critical cysteine residue."
lansoprazole affects CTSB
| 1
| 1
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"Lansoprazole was also shown to inhibit both legumain and cathepsin B in various cell models like HEK293, M38L and RAW264.7, but not in human bone marrow derived skeletal (mesenchymal) stem cells (hBMSC-TERT)."
| 1
Iminodiacetic acid inhibits CTSB. 1 / 1
| 1
sparser
"Since cathepsin B1 is slightly inhibited by phosphate (4) N-(2-acetamido)iminodiacetic acid (ADA) was also tested at 0.05M concentration, at pH 6.0."
| 1
Hypochlorous acid inhibits CTSB. 1 / 1
| 1
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"Thus, the data indicate that HOCl modified LDL inactivates cathepsin B by a chloramine dependent mechanism, most likely via oxidation of the enzyme 's critical cysteine residue."
hydroxide affects CTSB
| 1
| 1
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"On the other hand, introduction of hydroxyl group at o -position of ring A enhanced cathepsin B inhibitory function (compound 7 vs other compounds)."
| 1
Hydrogen peroxide inhibits CTSB. 1 / 1
| 1
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"Thus hydrogen peroxide (0.3 mM) or 4-hydroxynonenal (1 nM) inactivated cathepsin B without inhibiting cathepsin H or lysosomal hydrolases such as alpha-L-fucosidase."
| 1
Hydrogen chloride inhibits CTSB. 1 / 1
| 1
sparser
"Firstly, D6 and DAPT reduced in vitro cathepsin B activity (Fig.  xref d) and lowered the levels of mature cathepsin B (Fig.  xref e, f) in SH-APPswe but not in SH-mock cells (Fig.  xref e), while NH 4 Cl strongly inhibited cathepsin B in both cell types (Fig.  xref d–f)."
heparin affects CTSB
| 1
heparin inhibits CTSB. 1 / 1
| 1
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"How does heparin prevent the pH inactivation of cathepsin B?"
gold(1+) affects CTSB
| 1
Gold(1+) inhibits CTSB. 1 / 1
| 1
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"Cathepsin B was 50% inhibited by 1 muM Zn (2+), and is reportedly inhibited by gold agents."
genistein affects CTSB
| 1
| 1
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"Genistein inhibited the activation of cathepsin B by des-Arg9-BK or L-Arg in a different fashion, suggesting that tyrosine kinase (s) is also involved in the activation."
fumaric acid affects CTSB
| 1
Fumaric acid inhibits CTSB. 1 / 1
| 1
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"While fumaric acid derivatives were reported not to inhibit calpain and cathepsin B, similar Michael acceptors with an azapeptide recognition group (16, XREF_FIG) have reported good activity against caspases XREF_BIBR."
fluoride affects CTSB
| 1
| 1
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"Cathepsin B like activity was totally inhibited by the specific inhibitor lepeptin (0.1 mM); while DPP-II-like activity was partially inhibited by Tris (10 mM) or puromycin (0.1 mM), which are specific for DPP II, and by phenylmethylsulphonyl fluoride (PMS-F), an inhibitor of serine class proteases."
dorsomorphin affects CTSB
| 1
| 1
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"Interestingly, cilostazol induced increased cathepsin B activation was prevented by sirtinol, compound C, or bafilomycin A1 (100 nM, a blocker of autophagosome to lysosome fusion [XREF_BIBR] (XREF_FIG)."
| 1
Divinyl sulfone inhibits CTSB. 1 / 1
| 1
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"This enhanced QM based scoring function is applied to a series of 20 vinyl sulfone based inhibitory compounds inactivating the cysteine peptidase cathepsin B1 of the Schistosoma mansoni parasite (SmCB1)."
disulfide affects CTSB
| 1
| 1
sparser
"Conversely, oxidized lipoamide disulfide inhibited cathepsin B over 5-250 microM."
| 1
Diphosphate(4-) inhibits CTSB. 1 / 1
| 1
reach
"As the NLRP3 inflammasome can be activated due to lysosomal damage and release of cathepsin B, ammonium chloride (NH 4 Cl) and chloroquine diphosphate (CQ), which inhibit endosomal-lysosomal system acidification, and CA-074-Me, which acts as a cell-permeable inhibitor of thiol proteases, were used to block lysosomal acidification and cathepsin B activity, respectively."
dioxygen affects CTSB
| 1
| 1
sparser
"In earlier studies photooxidative inactivation of active site cysteine residue-containing enzymes including protein tyrosine phosphatase 1B has been demonstrated ( xref , xref , xref ), and oxidative inactivation of cellular cathepsin B by Rose Bengal-dependent photosensitization and singlet oxygen generated from naphthalene endoperoxides has been reported ( xref , xref )."
desipramine affects CTSB
| 1
| 1
reach
"Moreover, desipramine also blocked CTSB activation, which is downstream of lysosomal ceramide (XREF_FIG)."
| 1
Dendrimer macromolecule inhibits CTSB. 1 / 1
| 1
sparser
"First generation ruthenium dendrimers inhibit Cathepsin-B, which may suggest potential antimetastatic properties of these compounds."
| 1
Dehydroascorbic acid inhibits CTSB. 1 / 1
| 1
reach
"Inactivation of intracellular proteolysis and cathepsin B enzyme activity by dehydroascorbic acid and reactivation by dithiothreitol in perfused rat heart."
curcumin affects CTSB
| 1
| 1
reach
"First, mTOR suppression is required for Curcumin induced lysosomal activation, based on two important findings : (i) Curcumin treatment inhibits the Akt-mTOR pathway, which is consistent with the previous reports; [XREF_BIBR, XREF_BIBR] (ii) Curcumin fails to block mTOR activity and increase lysosomal acidification and Cathepsin B activity in Tsc2 -/- MEFs."
clomiphene affects CTSB
| 1
| 1
reach
"We found that neither clomiphene nor toremifene inhibited the activity of either cathepsin B or cathepsin L (XREF_FIG and XREF_SUPPLEMENTARY)."
clenbuterol affects CTSB
| 1
| 1
reach
"Clenbuterol decreased cathepsin B activity in the EDL and gastrocnemius and increased the activity in the soleus after two weeks of continuous clenbuterol treatment."
chrysophanol affects CTSB
| 1
| 1
reach
"Chrysophanol competively inhibited cathepsin B with an IC 50 value of 0.7 muM."
bithionol affects CTSB
| 1
| 1
reach
"By utilizing MAPKK immunobloting (XREF_FIG), a hybrid toxin FP59 XREF_BIBR that enters host cells by utilizing PA, but kills cells by LF independent mechanism (XREF_FIG), and cathepsin-B FRET assay (XREF_FIG), we demonstrated that Bithionol does not inhibit proteolytic activities of cellular LF, furin, and cathepsin-B."
| 1
Beta-D-glucose inhibits CTSB. 1 / 1
| 1
reach
"An open question is why addition of zymosan reduced the inactivation of cathepsin B and S."
| 1
Bafilomycin A1 inhibits CTSB. 1 / 1
| 1
reach
"Interestingly, cilostazol induced increased cathepsin B activation was prevented by sirtinol, compound C, or bafilomycin A1 (100 nM, a blocker of autophagosome to lysosome fusion [XREF_BIBR] (XREF_FIG)."
| 1
Ammonium chloride inhibits CTSB. 1 / 1
| 1
reach
"As the NLRP3 inflammasome can be activated due to lysosomal damage and release of cathepsin B, ammonium chloride (NH 4 Cl) and chloroquine diphosphate (CQ), which inhibit endosomal-lysosomal system acidification, and CA-074-Me, which acts as a cell-permeable inhibitor of thiol proteases, were used to block lysosomal acidification and cathepsin B activity, respectively."
| 1
All-trans-retinol inhibits CTSB. 1 / 1
| 1
reach
"Retinol inhibited in vitro the activities of protease (cathepsins) and cathepsin B1."
| 1
| 1
reach
"In this work, we observed that alantolactone caused the accumulation of autophagosomes due to impaired autophagic degradation and substantially inhibited the activity and expression of CTSB and CTSD proteins that when depleted caused lysosomal dysfunction."
1 |
Acetylleucyl-leucyl-norleucinal inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL304784"
acetone affects CTSB
| 1
acetone inhibits CTSB. 1 / 1
| 1
reach
"The acetone extract of S. sempervirens was found to be antifungal towards Candida glabrata (IC50 = 15.98 microg/ml), and both the acetone and MeOH extracts inhibited the proteolytic activity of cathepsin B (IC50 = 4.58 and 5.49 microg/ml, resp.)"
acetaldehyde affects CTSB
| 1
| 1
reach
"A structurally homologous peptide aldehyde (ALLM), which inhibits cathepsin B and calpain but is a much weaker inhibitor of the proteasome, did not block transmigration."
TUDCA affects CTSB
| 1
TUDCA inhibits CTSB. 1 / 1
| 1
reach
"TUDCA preincubation led to a significant increase in amylase secretion after CCK-8 stimulation, a 50% reduction of intracellular trypsin activation, and reduced cathepsin B activity, although the effects for cathepsin B were not statistical significant."
SB 203580 affects CTSB
| 1
| 1
reach
"When added to MG-63 cells, IL-6 stimulated the production of cathepsin B, which was reduced significantly by the addition of SB203580, a specific p38 MAPK inhibitor."
Pro-Gln affects CTSB
| 1
Pro-Gln inhibits CTSB. 1 / 1
| 1
reach
"In WT astrocytes (XREF_FIG), PQ triggered oxidation reduces Cathepsin B activity, but a clear recovery takes place upon prolonged PQ exposure in parallel with lipid-peroxide clearance (XREF_FIG)."
NAC affects CTSB
| 1
NAC inhibits CTSB. 1 / 1
| 1
reach
"Furthermore, the use of NAC, an agent that inhibits ROS generation, was able to block the movement of cathepsin B to the cytosol, inhibit the release cytochrome C, moderate the Bax and Bcl -2 ratio, and prevent caspase-9 and caspase-3 activation mediated by heat stress both in vitro and in vivo."
| 1
reach
"We have previously shown that APP-secretase activity is not inhibited by exogenously added proteinase inhibitors of different specificity (De Strooper, B., F. Van Leuven, and H. Van Den Berghe."
| 1
reach
"Cathepsin B activation by BK or L-Arg but not des-Arg9-BK was inhibited by L-NMMA (inhibitor of NO synthesis), and the activation by L-Arg was enhanced by beta-glycerophosphate (beta-GP : inhibitor of phosphatases), while the activation by BK or des-Arg9-BK was inhibited by beta-GP."
FADH2 affects CTSB
| 1
FADH2 inhibits CTSB. 1 / 1
| 1
reach
"The American Food and Drug Administration (FDA) has attempted to eliminate the distribution of faulty apps related to health care [XREF_BIBR]."
E64 affects CTSB
1 |
E64 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL374508"
DAPT affects CTSB
| 1
DAPT inhibits CTSB. 1 / 1
| 1
reach
"Firstly, D6 and DAPT reduced in vitro cathepsin B activity and lowered the levels of mature cathepsin B in SH-APPswe but not in SH-mock cells, while NH 4 Cl strongly inhibited cathepsin B in both cell types."
CHEMBL98832 affects CTSB
1 |
CHEMBL98832 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL98832"
CHEMBL98540 affects CTSB
1 |
CHEMBL98540 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL98540"
CHEMBL92114 affects CTSB
1 |
CHEMBL92114 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL92114"
CHEMBL91991 affects CTSB
1 |
CHEMBL91991 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL91991"
CHEMBL91704 affects CTSB
1 |
CHEMBL91704 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL91704"
CHEMBL89835 affects CTSB
1 |
CHEMBL89835 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL89835"
CHEMBL89766 affects CTSB
1 |
CHEMBL89766 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL89766"
CHEMBL89100 affects CTSB
1 |
CHEMBL89100 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL89100"
CHEMBL89008 affects CTSB
1 |
CHEMBL89008 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL89008"
CHEMBL88895 affects CTSB
1 |
CHEMBL88895 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL88895"
CHEMBL88646 affects CTSB
1 |
CHEMBL88646 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL88646"
CHEMBL8816 affects CTSB
1 |
CHEMBL8816 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL8816"
CHEMBL8796 affects CTSB
1 |
CHEMBL8796 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL8796"
CHEMBL8726 affects CTSB
1 |
CHEMBL8726 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL8726"
CHEMBL87150 affects CTSB
1 |
CHEMBL87150 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL87150"
CHEMBL87146 affects CTSB
1 |
CHEMBL87146 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL87146"
CHEMBL86453 affects CTSB
1 |
CHEMBL86453 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL86453"
CHEMBL8577 affects CTSB
1 |
CHEMBL8577 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL8577"
CHEMBL8547 affects CTSB
1 |
CHEMBL8547 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL8547"
CHEMBL80933 affects CTSB
1 |
CHEMBL80933 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL80933"
CHEMBL80605 affects CTSB
1 |
CHEMBL80605 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL80605"
CHEMBL77784 affects CTSB
1 |
CHEMBL77784 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL77784"
CHEMBL608115 affects CTSB
1 |
CHEMBL608115 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL608115"
CHEMBL604281 affects CTSB
1 |
CHEMBL604281 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL604281"
CHEMBL595637 affects CTSB
1 |
CHEMBL595637 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL595637"
CHEMBL540964 affects CTSB
1 |
CHEMBL540964 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL540964"
CHEMBL536336 affects CTSB
1 |
CHEMBL536336 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL536336"
CHEMBL523166 affects CTSB
1 |
CHEMBL523166 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL523166"
CHEMBL521987 affects CTSB
1 |
CHEMBL521987 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL521987"
CHEMBL521771 affects CTSB
1 |
CHEMBL521771 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL521771"
CHEMBL521636 affects CTSB
1 |
CHEMBL521636 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL521636"
CHEMBL521260 affects CTSB
1 |
CHEMBL521260 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL521260"
CHEMBL518284 affects CTSB
1 |
CHEMBL518284 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL518284"
CHEMBL502439 affects CTSB
1 |
CHEMBL502439 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL502439"
CHEMBL496424 affects CTSB
1 |
CHEMBL496424 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL496424"
CHEMBL493039 affects CTSB
1 |
CHEMBL493039 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL493039"
CHEMBL493038 affects CTSB
1 |
CHEMBL493038 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL493038"
CHEMBL493018 affects CTSB
1 |
CHEMBL493018 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL493018"
CHEMBL492619 affects CTSB
1 |
CHEMBL492619 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL492619"
CHEMBL492617 affects CTSB
1 |
CHEMBL492617 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL492617"
CHEMBL492175 affects CTSB
1 |
CHEMBL492175 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL492175"
CHEMBL486232 affects CTSB
1 |
CHEMBL486232 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL486232"
CHEMBL477531 affects CTSB
1 |
CHEMBL477531 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL477531"
CHEMBL470973 affects CTSB
1 |
CHEMBL470973 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL470973"
CHEMBL468202 affects CTSB
1 |
CHEMBL468202 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL468202"
CHEMBL450218 affects CTSB
1 |
CHEMBL450218 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL450218"
CHEMBL446718 affects CTSB
1 |
CHEMBL446718 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL446718"
CHEMBL439590 affects CTSB
1 |
CHEMBL439590 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL439590"
CHEMBL437251 affects CTSB
1 |
CHEMBL437251 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL437251"
CHEMBL436604 affects CTSB
1 |
CHEMBL436604 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL436604"
CHEMBL435913 affects CTSB
1 |
CHEMBL435913 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL435913"
CHEMBL433985 affects CTSB
1 |
CHEMBL433985 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL433985"
CHEMBL433692 affects CTSB
1 |
CHEMBL433692 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL433692"
CHEMBL430922 affects CTSB
1 |
CHEMBL430922 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL430922"
CHEMBL429947 affects CTSB
1 |
CHEMBL429947 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL429947"
CHEMBL424669 affects CTSB
1 |
CHEMBL424669 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL424669"
CHEMBL423923 affects CTSB
1 |
CHEMBL423923 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL423923"
CHEMBL423112 affects CTSB
1 |
CHEMBL423112 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL423112"
CHEMBL422260 affects CTSB
1 |
CHEMBL422260 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL422260"
CHEMBL418661 affects CTSB
1 |
CHEMBL418661 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL418661"
CHEMBL418606 affects CTSB
1 |
CHEMBL418606 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL418606"
CHEMBL414776 affects CTSB
1 |
CHEMBL414776 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL414776"
CHEMBL414669 affects CTSB
1 |
CHEMBL414669 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL414669"
CHEMBL414145 affects CTSB
1 |
CHEMBL414145 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL414145"
CHEMBL412852 affects CTSB
1 |
CHEMBL412852 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL412852"
CHEMBL409950 affects CTSB
1 |
CHEMBL409950 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL409950"
CHEMBL409949 affects CTSB
1 |
CHEMBL409949 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL409949"
CHEMBL409948 affects CTSB
1 |
CHEMBL409948 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL409948"
CHEMBL409947 affects CTSB
1 |
CHEMBL409947 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL409947"
CHEMBL409875 affects CTSB
1 |
CHEMBL409875 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL409875"
CHEMBL4092255 affects CTSB
1 |
CHEMBL4092255 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL4092255"
CHEMBL407633 affects CTSB
1 |
CHEMBL407633 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL407633"
CHEMBL407264 affects CTSB
1 |
CHEMBL407264 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL407264"
CHEMBL405602 affects CTSB
1 |
CHEMBL405602 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL405602"
CHEMBL400387 affects CTSB
1 |
CHEMBL400387 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL400387"
CHEMBL399733 affects CTSB
1 |
CHEMBL399733 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL399733"
CHEMBL399063 affects CTSB
1 |
CHEMBL399063 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL399063"
CHEMBL3982135 affects CTSB
1 |
CHEMBL3982135 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL3982135"
CHEMBL397972 affects CTSB
1 |
CHEMBL397972 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL397972"
CHEMBL3974643 affects CTSB
1 |
CHEMBL3974643 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL3974643"
CHEMBL3974129 affects CTSB
1 |
CHEMBL3974129 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL3974129"
CHEMBL3954506 affects CTSB
1 |
CHEMBL3954506 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL3954506"
CHEMBL394270 affects CTSB
1 |
CHEMBL394270 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL394270"
CHEMBL393733 affects CTSB
1 |
CHEMBL393733 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL393733"
CHEMBL3936923 affects CTSB
1 |
CHEMBL3936923 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL3936923"
CHEMBL393673 affects CTSB
1 |
CHEMBL393673 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL393673"
CHEMBL3934979 affects CTSB
1 |
CHEMBL3934979 inhibits CTSB. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL3934979"
CHEMBL393354 affects CTSB
1