Small molecule inhibitors of CTSL assembled by INDRA

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24,25-Dihydroxyvitamin D affects CTSL

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24,25-Dihydroxyvitamin D inhibits CTSL. 6 / 6

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"Vitamin D depletes or inhibits CTSL leading to increased genomic instability and compromised cancer cell proliferation after irradiation and treatment with PARP inhibitors XREF_BIBR."

25869442

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"Vitamin D treatment inhibits CTSL mediated degradation of 53BP1 and stabilizes VDR and BRCA1 levels."

28073589

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"In addition, our in vitro data show that vitamin D inhibits CTSL mediated degradation of 53BP1."

23337117

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"In support of this notion, vitamin D treatment inhibits CTSL mediated degradation of 53BP1 in a variety of contexts, including BRCA1 deficient and lamin A/C deficient cells XREF_BIBR, XREF_BIBR."

27041576

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"In addition, vitamin D stabilizes, at least partially, the levels of 53BP1 protein in senescent cells (XREF_FIG), without affecting 53BP1 transcripts levels (XREF_FIG), which could be explained by the role that vitamin D plays inhibiting CTSL activity 25."

27041576

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"We previously demonstrated that vitamin D inhibits CTSL activity and stabilizes 53BP1 protein in mouse embryonic fibroblasts."

23337117

leupeptin affects CTSL

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leupeptin inhibits CTSL. 4 / 4

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"Leupeptin and E-64 dose dependently inhibited both cathepsin B and cathepsin L activities, and pepstatin A strongly inhibited cathepsin D activity in rat kidney lysosomes."

10334387

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"These results suggest that leupeptin treatment caused significant inhibition of the intracellular maturation of cathepsin L."

7581248

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"Injection of leupeptin or E-64 into rats actually inhibits the activities of cathepsin B and cathepsin L in the lysosomal fraction of liver and results in inhibition of turnover rate of liver aldolase (11, 20)."

7051771

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"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL191881"

arsenite(3-) affects CTSL

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Arsenite(3-) inhibits CTSL. 4 / 4

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"At this time point, none of the arsenite concentrations affected cell viability (data not shown), but arsenite significantly decreased CathL activity in TA3 cells.Because arsenite inhibited CathL activity in intact cells, enzymatic kinetic analyses were performed."

11357877

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"Approximately 200 muM arsenite caused 50% inhibition of CathL activity regardless of the substrate concentration."

11357877

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"Additionally, the Ki of arsenite inhibition of CathL is similar to the chemical 's inhibition of other thiol enzymes [12,34]."

11357877

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"As shown in Fig. 1, arsenite inhibited CathL activity in a dose dependent fashion."

11357877

heparin affects CTSL

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heparin inhibits CTSL. 3 / 3

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"We show that heparin reduces the stability of the pro form of cathepsin L at pH 5 by binding to a putative heparin binding motif (BBXB) in the pro domain."

18086562

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"The presence of heparin accelerated inhibition of cathepsin L by both serpins, and in the case of SCCA-1, heparin increased the second order inhibition rate constant from 5.4 x 10 (5) to> 10 (8), indicating a rate enhancement of at least 180-fold."

19959474

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"For example, the glycosaminoglycan heparin, a known anti-coagulant, enhances inhibition of cathepsin L by serpin B3 and B4."

29632742

diphenylcyclopropenone affects CTSL

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diphenylcyclopropenone inhibits CTSL. 3 / 3

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"The ability of DPC to inhibit the activity of the HPLC peak III proteinase on Z-phe-arg-AMC at pH 4.5 was tested over a final concn range of 0.35-50 mM of inhibitor, (c) DPC inhibition of cathepsin L like activity from HPLC peak III was investigated over a pH range of 3.5-8.0."

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24096484

desferrioxamine B affects CTSL

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Desferrioxamine B inhibits CTSL. 1 / 1

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"Desferrioxamine prevents induction of both ferritin and cathepsin L by SPIONs."

22500704

cyclosporin A affects CTSL

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"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL258148"

GSSG affects CTSL

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GSSG inhibits CTSL. 1 / 1

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"The possibility of inhibition of CtsL by GSSG could be omitted because GSSG (up to 1mM) did not exhibit inhibitory activity towards CtsL in the present assay system (data not shown), and a final concentration of GSSG of the assay mixture containing CTLA-2alpha treated with GSSG was 0.12 mM."

25045530