Small molecule inhibitors of TMPRSS2 assembled by INDRA

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Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading
enzalutamide affects TMPRSS2
| 1
enzalutamide inhibits TMPRSS2. 1 / 1
| 1
reach
"Both RD162 and MDV3100 antagonized induction of PSA and TMPRSS2 by the synthetic androgen R1881 in parental LNCaP cells (XREF_SUPPLEMENTARY)."
19359544
celastrol affects TMPRSS2
| 1
celastrol inhibits TMPRSS2. 1 / 1
| 1
reach
"Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-kappaB Pathway in TMPRSS2 and ERG Fusion Gene Expressing Prostate Cancer."
23554889
bicalutamide affects TMPRSS2
| 1
bicalutamide inhibits TMPRSS2. 1 / 1
| 1
reach
"In VCaP cells, we were not able to prevent EB1089 mediated TMPRSS2 : ERG induction with an androgen receptor antagonist, Casodex, although in LNCaP cells, as reported for some other common androgen receptor and VDR target genes, Casodex reduces EB1089 mediated induction of TMPRSS2."
20147525
baicalein affects TMPRSS2
| 1
baicalein inhibits TMPRSS2. 1 / 1
| 1
reach
"Mechanism dissection suggest that baicalein can suppress AR target genes (PSA, TMPRSS2, and TMEPA1) expression in both androgen responsive LNCaP cells and castration resistant CWR22Rv1 cells, that may involve the inhibiting the AR N/C dimerization and AR-coactivators interaction."
29285272
CHEMBL1809251 affects TMPRSS2
1 |
CHEMBL1809251 inhibits TMPRSS2. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL1809251"
CHEMBL1809250 affects TMPRSS2
1 |
CHEMBL1809250 inhibits TMPRSS2. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL1809250"
CHEMBL1229259 affects TMPRSS2
1 |
CHEMBL1229259 inhibits TMPRSS2. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL1229259"
CHEMBL1215083 affects TMPRSS2
1 |
CHEMBL1215083 inhibits TMPRSS2. 1 / 1
1 |
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL1215083"