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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust ctd virhostnet phosphoelm | geneways tees isi trips rlimsp medscan sparser reach eidos
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Amodiaquine affects PfPMT
| 10
Amodiaquine inhibits PfPMT. 10 / 10
| 10
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"To better characterize inhibition of PfPMT by amodiaquine, we determined the IC (50) values of a series of aminoquinolines using a direct radiochemical assay."
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"Previous studies have also shown that PfPMT activity is inhibited by the 4-aminoquinoline compounds, amodiaquine (AQ) and chloroquine (CQ) with strong inhibition obtained with AQ."
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"Inhibition of PfPMT activity by amodiaquine in vitro and in yeast."
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"To better characterize inhibition of PfPMT by amodiaquine, we determined the IC 50 values of a series o aminoquinolines using a direct radiochemical assay."
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"Here we provide biochemical and biophysical data indicating that PfPMT activity is inhibited by amodiaquine (AQ)."
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"The poor inhibition of PfPMT by amodiaquine was comparable to the ~ 3 mM IC 50 values determined for the two PMT from the nematode parasite Haemonchus contortus 12."
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"Interestingly, PfPMT activity was not inhibited by the amodiaquine analog, chloroquine, or other aminoquinolines, amino alcohols, or histamine methyltransferase inhibitors."
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"Taken together, the effect on enzymatic activity, lack of binding in ITC experiments, and docking studies suggest that amodiaquine and other commonly used aminoquinolines weakly inhibit PfPMT."
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"In contrast to a previous report 17, amodiaquine was a weak inhibitor of PfPMT (IC 50 = 1.35 mM)."
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"To better understand amodiaquine inhibition of PfPMT, we determined the x-ray crystal structure of the enzyme in complex with S-adenosylhomocysteine (SAH) and amodiaquine 18."
Amodiaquine affects activity
| 8
Amodiaquine inhibits activity. 8 / 8
| 8
sparser
"Experiments in vitro have shown that the drug amodiaquine may inhibit Ebola virus activity."
sparser
"Amodiaquine, 10(-5) M, totally inhibited the activity of histamine-methyltransferase (HMT) in the rat brain."
sparser
"Inhibition of PfPMT activity by amodiaquine in vitro and in yeast."
sparser
"Chloroquine and amodiaquine inhibited Ca2+ stimulated PLD activity in dose dependent manner whereas these drugs had no significant effect on PLD activated by oxidants or polyamines."
sparser
"We tested amodiaquine in the Hsp27 chaperone assay and found that amodiaquine significantly inhibits Hsp27’s activity (see Methods for details) and that it was 43 more potent than BVDU."
sparser
"Inhibition of calcium stimulated PLD activity by chloroquine and amodiaquine was dose dependent as shown in Fig. 1 A. Chloroquine showed slightly more inhibition at lower dose as compared to amodiaquin."
sparser
"Here we provide biochemical and biophysical data indicating that PfPMT activity is inhibited by amodiaquine (AQ)."
sparser
"Experiments in vitro have shown that amodiaquine may inhibit Ebola virus activity."
Amodiaquine affects AMPK
| 3 5
Amodiaquine leads to the phosphorylation of AMPK. 8 / 8
| 3 5
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"Our findings suggest that chloroquine and amodiaquine successfully enhance AMPK phosphorylation under high-glucose conditions, resulting in increased PGC1alpha phosphorylation."
sparser
"At this time, we observed that chloroquine and amodiaquine enhanced AMPK phosphorylation, which led to increased PGC1α activity RPTCs under high-glucose conditions (Figs  xref – xref )."
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"Here, we showed that chloroquine and amodiaquine induce mitochondrial biogenesis and balance fusion and fission protein expression in RPTCs under high-glucose conditions and in diabetic kidneys, presumably by enhancing AMPK and PGC1alpha phosphorylation and activity."
sparser
"Chloroquine and amodiaquine enhance AMPK phosphorylation and improve mitochondrial fragmentation in diabetic tubulopathy."
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"At this time, we observed that chloroquine and amodiaquine enhanced AMPK phosphorylation, which led to increased PGC1alpha activity RPTCs under high-glucose conditions (Figs XREF_FIG - XREF_FIG)."
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"First, we investigated whether chloroquine or amodiaquine effectively augments AMPK phosphorylation in hRPTCs cultured under high-glucose conditions."
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"Chloroquine and amodiaquine enhance AMPK phosphorylation and improve mitochondrial fragmentation in diabetic tubulopathy."
sparser
"Our findings suggest that chloroquine and amodiaquine successfully enhance AMPK phosphorylation under high-glucose conditions, resulting in increased PGC1α phosphorylation."
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Amodiaquine increases the amount of CYP2C8.
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Amodiaquine increases the amount of CYP2C8. 4 / 4
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Amodiaquine inhibits CYP2C8.
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Amodiaquine phosphorylates CYP2C8.
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Amodiaquine phosphorylates CYP2C8. 1 / 1
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Amodiaquine decreases the amount of CYP2C8.
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Amodiaquine decreases the amount of CYP2C8. 1 / 1
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Amodiaquine affects HNMT
4 | 1 2
4 | 1 2
sparser
"IC50 values for the inhibition of mouse kidney HNMT by amodiaquine and S-adenosyl-L-homocysteine were 1.67 and 11.8 microM, respectively."
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"HNMT exhibits high substrate specificity for histamine and is inhibited by its reaction products, as well as by the SH-group reagents p-chloromercuribenzoate and N-ethylmaleimide and by the antimalarial drugs quinacrine and amodiaquine [XREF_BIBR]."
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"Amodiaquine, quinacrine and 1,4-(tele)-methyl-HI weakly inhibited HMT activity ex vivo and they failed to alter HI levels in the rat brain."
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL1357648"
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL1357648"
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL1357648"
tas
"Experimental assay, see https://identifiers.org/chembl.compound/CHEMBL1357648"
| 6
| 3
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"L-Histidine, histamine ivc, and amodiaquine (inhibitor of histamine catabolism) enhanced catalepsy induced by morphine, codeine and fentanyl."
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"Augmentation of pentagastrin stimulated gastric secretion in the Heidenhain pouch dog by amodiaquine : inhibition of histamine methyltransferase in vivo?"
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"This effect was specific to the H2-receptor blocking activity of these drugs : equivalent degrees of receptor blockade by four different H2 antihistamines resulted in equipotent enhancement; H1-receptor antagonists did not alter histamine release; and aminoguanidine and amodiaquine, agents that inhibit histamine metabolism but do not block H2 receptors, did not enhance histamine release."
Amodiaquine increases the amount of histamine.
| 1
Amodiaquine increases the amount of histamine. 1 / 1
| 1
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"The subcutaneous injection of amodiaquine (2 and 5 mg/kg) significantly increased the histamine levels in the liver in comparison to saline treated mice."
Amodiaquine demethylates histamine.
| 1
Amodiaquine leads to the demethylation of histamine. 1 / 1
| 1
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"Amodiaquine definitely inhibits histamine methylation in vivo."
Amodiaquine activates histamine.
| 1
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"This effect was specific to the H2-receptor blocking activity of these drugs : equivalent degrees of receptor blockade by four different H2 antihistamines resulted in equipotent enhancement; H1-receptor antagonists did not alter histamine release; and aminoguanidine and amodiaquine, agents that inhibit histamine metabolism but do not block H2 receptors, did not enhance histamine release."
| 6
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"In contrast to other antimalarial agents, amodiaquine (because it contains a 4-aminophenol function) depleted glutathione in activated neutrophils, by formation of an electrophilic quinoneimine metabolite."
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"Substitution of the 4 '-hydroxyl group in amodiaquine with a fluorine, by preventing oxidation to the quinone- imine, completely abolished the depletion of intracellular glu- tathione."
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"In the presence of PMA, there was enhanced depletion of glutathione by amodiaquine, which was concentration-de- pendent and reached a minimum of 46.7 +/- 7.1% of solvent control values (1.9 +/- 0.1 nmol glutathione/106 cells)."
| 3
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"The levels of lipid peroxidation were higher when glutathione depleted cells were treated with amodiaquine (XREF_FIG)."
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"In the presence of PMA, there was enhanced depletion of glutathione by amodiaquine, which was concentration-de- pendent and reached a minimum of 46.7 +/- 7.1% of solvent control values (1.9 +/- 0.1 nmol glutathione/106 cells)."
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"Inhibition of glutathione dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action."
| 5
| 4
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"Interestingly, autophagy inhibition caused by amodiaquine is not involved in the inhibition of rRNA transcription, suggesting two independent anticancer mechanisms."
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"In contrast to our results, a previous study demonstrated that amodiaquine treatment inhibited autophagy function in a melanoma cell line."
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"Interestingly, autophagy inhibition caused by amodiaquine is not involved in the inhibition of rRNA transcription, suggesting two independent anticancer mechanisms."
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"CQ, QN, MQ, and amodiaquine have been previously shown to inhibit autophagy, while the remaining antimalarial agents tested (piperaquine, primaquine, and artemisinin) have not to our knowledge."
Amodiaquine activates autophagy.
| 1
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"Amodiaquine and Thiethylperazine Upregulate Lysosomal Glycosphingolipid Degradation Enzymes and Activate Autophagy."
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Amodiaquine increases the amount of CYP3A4.
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Amodiaquine increases the amount of CYP3A4. 3 / 3
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Amodiaquine phosphorylates CYP3A4.
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Amodiaquine phosphorylates CYP3A4. 1 / 1
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Amodiaquine decreases the amount of CYP3A4.
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Amodiaquine decreases the amount of CYP3A4. 1 / 1
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| 4
Amodiaquine inhibits glucose.
| 2
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"Also, AMPK knocked down significantly attenuated normalization of Mfn1-to-Drp1 ratio by chloroquine and amodiaquine in hRPTCs under high glucose condition."
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"Chloroquine and amodiaquine attenuate the effect of high glucose concentrations on mitochondrial biogenesis and fragmentation in RPTCs."
Amodiaquine activates glucose.
| 2
| 2
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"Our data showed that chloroquine- and amodiaquine induced increases in PGC1alpha activity overcome the effects of high glucose on mitochondrial mass and fragmentation and ROS generation in hRPTCs (Figs XREF_FIG, XREF_FIG)."
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"Amodiaquine selectively activated the transcriptional activities of PPARalpha and gamma, and enhanced both fatty acid oxidation and glucose uptake without altering insulin secretion in vitro."
| 4
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"Then, mice brains were sampled and analyzed to quantify levels of GM1 ganglioside; AF488-CTB staining revealed that both amodiaquine and thiethylperazine treatments could reduce the signal of GM1 ganglioside in the BKO mice compared with the controls (XREF_FIG A and XREF_SUPPLEMENTARY A)."
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"Among them, amodiaquine and thiethylperazine also reduced GM1 ganglioside accumulation in the model mice."
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"We showed that amodiaquine and thiethylperazine reduced GM1 ganglioside accumulation with activating autophagy."
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"These results suggest that both amodiaquine and thiethylperazine can reduce GM1 ganglioside accumulation and recover the presynaptic dysfunction characteristic of disease derived neurons."
Amodiaquine affects ACHE
1 | 1 2
1 | 1 2
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"Screening result -- Amodiaquine reactivates inhibited AChE."
sparser
"This suggests that the inhibition of AChE by amodiaquine may involve binding of the protonated diethylamino and phenolic hydroxyl functions to the anionic and esteric sites of the enzyme respectively."
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"This suggests that the inhibition of AChE by amodiaquine may involve binding of the protonated diethylamino and phenolic hydroxyl functions to the anionic and esteric sites of the enzyme respectively."
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| 1 2
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"Herein, we report a novel activity of the FDA approved antimalarial drug amodiaquine which inhibits rRNA transcription, a rate limiting step for ribosome biogenesis, in a dose dependent manner."
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"Herein, we report a novel activity of the FDA approved antimalarial drug amodiaquine which inhibits rRNA transcription, a rate limiting step for ribosome biogenesis, in a dose dependent manner."
sparser
"Herein, we report a novel activity of the FDA-approved antimalarial drug amodiaquine which inhibits rRNA transcription, a rate-limiting step for ribosome biogenesis, in a dose-dependent manner."
Amodiaquine affects replication
| 3
Amodiaquine inhibits replication. 3 / 3
| 3
sparser
"However, there is evidence that amodiaquine inhibits virus replication of flaviviridae including dengue virus xref and there is also evidence that it interferes with thymidine production xref ."
sparser
"In addition to its antiviral activity determined in viral plaque formation inhibition assay, amodiaquine also inhibited viral replication in growth kinetics assays ( xref )."
sparser
"Careful observation at one Ebola treatment centre determined that malaria treatment (for possible concomitant infection) that included amodiaquine, which inhibits Ebola virus replication in vitro, might be associated with improved survival from Ebola virus disease. xref This hypothesis-generating observational study needs to be investigated further in non-human primate models before being considered for a formal clinical trial."
| 3
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"Furthermore, when a non toxic H (2) O (2) generating system and peroxidase was used to mimic the products formed by inflammatory immune cells, only 15microM amodiaquine was required to cause 50% cell death."
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"NAC effectively prevented cell death induced by amodiaquine in glutathione depleted hepatocytes (XREF_FIG) but taurine showed no significant effects in this situation (data not given)."
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"The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy induced cell death."
| 3
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"A significant amount of ROS was formed when hepatocytes were treated with amodiaquine (XREF_FIG), which could suggest the occurrence of oxidative stress after amodiaquine administration to hepatocytes."
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"Amodiaquine induced ROS formation."
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"Chloroquine and amodiaquine reduce mitochondrial ROS production and apoptosis in RPTCs in a high-glucose environment."
Amodiaquine affects HSPB1
| 3
Amodiaquine inhibits HSPB1.
| 2
| 2
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"We show that amodiaquine inhibits the chaperone function of the heat shock protein Hsp27, which plays a key role in the chemoresistance of some tumor types 15."
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"We obtained proof that amodiaquine inhibits Hsp27 function, but binding to thymidine kinase and any anti-viral activities were not tested."
Amodiaquine activates HSPB1.
| 1
| 1
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"We validated our prediction by showing that amodiaquine suppresses chemoresistance in a multiple myeloma cancer cell line by inhibiting the chaperone function of the cancer target Hsp27."
Amodiaquine affects GM1 ganglioside accumulation
| 3
Amodiaquine inhibits GM1 ganglioside accumulation. 3 / 3
| 3
eidos
"These results suggest that both amodiaquine and thiethylperazine can reduce GM1 ganglioside accumulation and recover the presynaptic dysfunction characteristic of disease-derived neurons ."
eidos
"We showed that amodiaquine and thiethylperazine reduced GM1 ganglioside accumulation with activating autophagy ."
eidos
"Among them , amodiaquine and thiethylperazine also reduced GM1 ganglioside accumulation in the model mice ."
Amodiaquine affects DENV2
| 3
Amodiaquine inhibits DENV2. 3 / 3
| 3
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"Additionally, amodiaquine (AQ) inhibited DENV2 infectivity with EC 50 and EC 90 values of 1.08 +/-0.09 muM and 2.69 +/-0.47 muM, respectively, and inhibited viral RNA replication with an EC 50 value of 7.41 +/-1.09 muM in the replicon expressing cells [XREF_BIBR]."
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"Amodiaquine (AQ), one of the 4-aminoquinoline drugs, inhibited DENV2 infectivity measured by plaque assays, with EC 50 and EC 90 values of 1.08 +/- 0.09 microM and 2.69 +/- 0.47 microM, respectively, and DENV2 RNA replication measured by Renilla luciferase reporter assay, with EC 50 value of 7.41 +/- 1.09 microM in the replicon expressing cells."
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"Amodiaquine (AQ), one of the 4-aminoquinoline drugs, inhibited DENV2 infectivity measured by plaque assays, with EC50 and EC90 values of 1.08 +/-0.09 muM and 2.69 +/-0.47 muM, respectively, and DENV2 RNA replication measured by Renilla luciferase reporter assay, with EC50 value of 7.41 +/-1.09 muM in the replicon expressing cells."
| 1 2
| 1 2
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"A single dose of amodiaquine decreased CYP2D6 and CYP2C9 activities significantly compared to baseline values."
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"Proguanil, cycloguanil, amodiaquine, and desethylamodiaquine inhibited CYP2D6 (K (i) = 6.76, 5.97, 2.1, and 4.13 microM, respectively)."
sparser
"Proguanil, cycloguanil, amodiaquine, and desethylamodiaquine inhibited CYP2D6 (K(i) = 6.76, 5.97, 2.1, and 4.13 microM, respectively)."
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Amodiaquine inhibits CYP1A2.
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Amodiaquine increases the amount of CYP1A2.
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Amodiaquine increases the amount of CYP1A2. 1 / 1
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| 2
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"In both glomeruli and tubules, the diamine oxidase inhibitor, amino-guanidine, abolished the production of acid metabolites while amodiaquine and pyrilamine, inhibitors of the methylation pathway, markedly reduced the production of N tau-methylhistamine."
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"SK & F 91581 (10 (-4) M) and amodiaquine (10 (-4) M) reduced the proportion of N tau-methylhistamine and acid metabolites after a 30 min incubation."
Amodiaquine affects infectivity
| 2
Amodiaquine inhibits infectivity. 2 / 2
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eidos
"For example , chloroquine is active against human coronavirus OC43 ( in vitro and in infected mice ) as well as SARS ( in vitro ) 10,30,31 , while amodiaquine also inhibits dengue virus 2 replication and infectivity in vitro 11 ."
eidos
"Boonyasuppayakorn S , Reichert ED , Manzano M , et al. : Amodiaquine , an antimalarial drug , inhibits dengue virus type 2 replication and infectivity ."
Amodiaquine affects heme
| 2
| 2
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"Several 4-aminoquinolines, notably chloroquine (CQ) and amodiaquine (AQ), are thought to act primarily by binding hemozoin crystals at their actively growing surfaces and thus preventing further incorporation and detoxification of free heme."
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"It is well established that CQ and amodiaquine (AQ) accumulate in the parasite 's food vacuole and inhibit heme polymerization, thereby increasing its efflux out of the food vacuole."
Amodiaquine affects dengue virus replication
| 2
Amodiaquine inhibits dengue virus replication. 2 / 2
| 2
eidos
"Boonyasuppayakorn S , Reichert ED , Manzano M , et al. : Amodiaquine , an antimalarial drug , inhibits dengue virus type 2 replication and infectivity ."
eidos
"For example , chloroquine is active against human coronavirus OC43 ( in vitro and in infected mice ) as well as SARS ( in vitro ) 10,30,31 , while amodiaquine also inhibits dengue virus 2 replication and infectivity in vitro 11 ."
| 2
| 1
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"Amodiaquine competitively inhibits chloroquine accumulation, and vice versa, suggesting that these compounds share a similar mechanism of accumulation (Fitch, 1973)."
| 1
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"In vivo, within 7 days 10 mg/kg chloroquine failed in 8 of the 21 treated patients, 25 mg/kg chloroquine failed in 1/43 and none of these patients treated with 10 mg/kg amodiaquine failed."
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"Anti-inflammatory activity of chloroquine and amodiaquine through p21 mediated suppression of T cell proliferation and Th1 cell differentiation."
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"The antimalarial compound amodiaquine (AQ) and NSC158011, a compound identified following screening of the NCI diversity library, were found to act as non competitive inhibitors of PfPMT and inhibit parasite development and differentiation XREF_BIBR XREF_BIBR."
| 2
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"We observed that chloroquine and amodiaquine induce a fall in AMP and ATP in hRPTCs under high-glucose conditions, which may be responsible for the AMPK activation."
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"We observed that chloroquine and amodiaquine induce a fall in AMP and ATP ratio in hRPTCs under high-glucose environment which may be responsible for AMPK activation."
Amodiaquine affects TGFB1
| 2
Amodiaquine decreases the amount of TGFB1. 2 / 2
| 2
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"XREF_FIG, Chloroquine and amodiaquine suppressed TGF-beta1 expression, which was upregulated in high-glucose conditions, and attenuated the increases in -smooth muscle actin (SMA) and fibronectin expression induced by high glucose concentrations."
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"As illustrated by our results, chloroquine or amodiaquine abolished high-glucose-induced dysregulation of TGF-beta1 expression and suppressed partial EMT in RPTCs under high-glucose conditions."
Amodiaquine affects STK11
| 1 1
Amodiaquine phosphorylates STK11. 2 / 2
| 1 1
sparser
"We also did western blot analysis which revealed that chloroquine and amodiaquine induce LKB1 (liver kinase B1, a major upstream AMPK kinase) phosphorylation under high glucose condition (Supplementary Fig.  xref )."
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"Chloroquine and amodiaquine also contribute to phosphorylate LKB1 in hRPTCs subject to high glucose."
| 2
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"Amodiaquine triggers degradation of the catalytic subunit of RNA polymerase I (Pol I), with ensuing RPL5 and RPL11 dependent stabilization of p53."
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"Amodiaquine triggers degradation of the catalytic subunit of RNA polymerase I (Pol I), with ensuing RPL5 and RPL11 dependent stabilization of p53."
| 2
Amodiaquine phosphorylates PPARGC1A.
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Amodiaquine leads to the phosphorylation of PPARGC1A. 1 / 1
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"Here, we showed that chloroquine and amodiaquine induce mitochondrial biogenesis and balance fusion and fission protein expression in RPTCs under high-glucose conditions and in diabetic kidneys, presumably by enhancing AMPK and PGC1alpha phosphorylation and activity."
Amodiaquine activates PPARGC1A.
| 1
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"Immunoblot analysis confirmed that AMPKalpha and PGC1alpha activity was restored in the kidneys of diabetic mice treated with chloroquine or amodiaquine."
Amodiaquine affects EC
| 2
Amodiaquine inhibits EC. 2 / 2
| 2
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"* Amodiaquine inhibited dengue virus infectivity with EC 50 and EC 90 values of 1.08 +/-0.09 and 2.69 +/-0.47 muM, respectively."
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"Amodiaquine (AQ), one of the 4-aminoquinoline drugs, inhibited DENV2 infectivity measured by plaque assays, with EC 50 and EC 90 values of 1.08 +/- 0.09 microM and 2.69 +/- 0.47 microM, respectively, and DENV2 RNA replication measured by Renilla luciferase reporter assay, with EC 50 value of 7.41 +/- 1.09 microM in the replicon expressing cells."
Amodiaquine affects EBOV infection
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Amodiaquine inhibits EBOV infection. 2 / 2
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eidos
"Consistent with previous reports using other cell types , the parent compound , amodiaquine , inhibited EBOV infection , with a 50 % inhibitory concentration ( IC 50 ) in the micromolar range ( 2.13 muM , Fig. 1A ) ."
eidos
"Amodiaquine and its derivatives inhibit EBOV infection ."
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"Likewise, amodiaquine, benzbromarone, disulfiram and bicalutamide decreased cell viability only in BSO treated HepG2 cells."
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"Interestingly, there were cell-type dependent effects of BSO treatment on cell viability as amodiaquine, benzbromarone, bicalutamide, and disulfiram significantly decreased cell viability under BSO treatment only in HepG2 cells but not in HepaRG cells."
Amodiaquine affects ATP
| 2
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"We observed that chloroquine and amodiaquine induce a fall in AMP and ATP in hRPTCs under high-glucose conditions, which may be responsible for the AMPK activation."
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"We observed that chloroquine and amodiaquine induce a fall in AMP and ATP ratio in hRPTCs under high-glucose environment which may be responsible for AMPK activation."
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Amodiaquine increases the amount of CYP2D6. 2 / 2
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"A single dose of amodiaquine decreased CYP2D6 and CYP2C9 activities significantly compared to baseline values."
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Amodiaquine inhibits CYP2C19.
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Amodiaquine increases the amount of CYP2C19.
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Amodiaquine increases the amount of CYP2C19. 1 / 1
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Amodiaquine increases the amount of CYP1A1.
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Amodiaquine increases the amount of CYP1A1. 1 / 1
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Amodiaquine activates CYP1A1.
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| 1
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"However as indicated for amodiaquine such small increase in Bas-Ap transport will have negligible effect on systemic absorption."
| 1
Amodiaquine decreases the amount of testosterone. 1 / 1
| 1
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"Testosterone level was decreased by artesunate [37%], sulfadoxine and pyrimethamine [22%], amodiaquine [14%], artesunate/sulfadoxine/pyrimethamine [41%] and artesunate and amodiaquine [49%] at the clinical dose, compared to the serum levels in control animals."
Amodiaquine affects rare liver injury
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Amodiaquine activates rare liver injury. 1 / 1
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eidos
"Moreover , as amodiaquine induces rare but serious liver injury , which was suggested to be caused by P450-mediated drug metabolism , these modifications may also affect toxicity of the derivatives in vivo and will need verification ( Shimizu et al ., 2009 ) ."
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"The antimalarial drugs amodiaquine, quinacrine and chloroquine inhibit the catabolism of putrescine by the rat."
Amodiaquine affects process
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Amodiaquine inhibits process. 1 / 1
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sparser
"This process is effectively inhibited by chloroquine (CQ) and amodiaquine (AQ)."
Amodiaquine affects presynaptic disease-derived neurons
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Amodiaquine inhibits presynaptic disease-derived neurons. 1 / 1
| 1
eidos
"List of Hit Compounds that Can Reduce the GM1 Ganglioside Accumulation We next examined whether amodiaquine and thiethylperazine could restore the presynaptic deficit in disease-derived neurons ."
| 1
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"The Role of CD8 T Cells in Amodiaquine Induced Liver Injury in PD1-/- Mice Cotreated with Anti-CTLA-4."
| 1
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"The abilities of TSAHC to inhibit phenacetin Odeethylation (CYP1A2), coumarin 6 hydroxylation (CYP2A6), bupropion hydroxylation (CYP2B6), amodiaquine Ndeethylation (CYP2C8), diclofenac 4 hydroxylation (CYP2C9), omeprazole 5 hydroxylation (CYP2C19), dextromethorphan O demethylation (CYP2D6), chlorzoxazone 6 hydroxylation (CYP2E1), and midazolam 1 '-hydroxylation (CYP3A) were tested using human liver microsomes."
Amodiaquine affects pfmdr1
| 1
Amodiaquine activates pfmdr1. 1 / 1
| 1
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"Specifically, these authors propose that pfmdr1 mediates a more stable, persistent form of CQR in South America and that this advantaged pfmdr1 x pfcrt allelic combination may be induced in Africa by increased use of amodiaquine."
Amodiaquine affects parasitaemic PROGUANIL-DAPSONE FOR FALCIPARUM MALARIA IN TANZANIA 435
| 1
Amodiaquine activates parasitaemic PROGUANIL-DAPSONE FOR FALCIPARUM MALARIA IN TANZANIA 435. 1 / 1
| 1
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"Subjects parasitaemic PROGUANIL-DAPSONE FOR FALCIPARUM MALARIA IN TANZANIA 435 on day 14 were treated with amodiaquine at the standard dose of 25 mg/kg over 3 days (10/10/5)."
| 1
sparser
"Although amodiaquine inhibits each structurally-related methyltransferase, the binding locations of amodiaquine in PfPMT (surface site) and HNMT (active site) differ, as does inhibitor effectiveness."
Amodiaquine affects methylation
| 1
Amodiaquine inhibits methylation. 1 / 1
| 1
sparser
"Amodiaquine definitely inhibits histamine methylation in vivo."
| 1
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"Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo."
Amodiaquine affects labeling
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Amodiaquine inhibits labeling. 1 / 1
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sparser
"The structurally related antimalarials amodiaquine and quinine also inhibited labeling of the two proteins, while verapamil and doxycycline had no effect."
Amodiaquine affects host cathepsin B.
| 1
Amodiaquine inhibits host cathepsin B.. 1 / 1
| 1
eidos
"Scientific RepoRts | 5:13476 | DOi : 10.1038 / srep13476 Amodiaquine inhibits host cathepsin B. ( a ) AQ does not inhibit PA binding to RAW264.7 cells ."
Amodiaquine affects histamine-methyltransferase
| 1
Amodiaquine inhibits histamine-methyltransferase. 1 / 1
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reach
"Amodiaquine, 10 (-5) M, totally inhibited the activity of histamine-methyltransferase (HMT) in the rat brain."
| 1
reach
"Another antimalarial agent, amodiaquine, at a con- centration of 0.1 mM did reduce ST (550 units/ml) activation of guanylate cyclase by 44 +/- 2%."
Amodiaquine affects glycoprotein-dependent entry EBOV
| 1
Amodiaquine inhibits glycoprotein-dependent entry EBOV. 1 / 1
| 1
eidos
"Amodiaquine and its derivatives inhibit glycoprotein-dependent entry of EBOV ."
Amodiaquine affects gam
| 1
| 1
reach
"Amodiaquine selectively activated the transcriptional activities of PPARalpha and gamma, and enhanced both fatty acid oxidation and glucose uptake without altering insulin secretion in vitro."
Amodiaquine affects filovirus replication
| 1
Amodiaquine inhibits filovirus replication. 1 / 1
| 1
eidos
"Previous investigations have demonstrated that amodiaquine inhibits filovirus replication , and the mechanism of action is hypothesized to be similar to that of CQ [ 43 ] ."
Amodiaquine affects ferriprotoporphyrin IX
| 1
Amodiaquine activates ferriprotoporphyrin IX. 1 / 1
| 1
reach
"We have shown previously that chloroquine and amodiaquine inhibit the glutathione dependent degradation of ferriprotoporphyrin IX (FP)."
Amodiaquine affects enzyme activity
| 1
Amodiaquine inhibits enzyme activity. 1 / 1
| 1
sparser
"PkPMTs enzyme activity could be inhibited by amodiaquine, chloroquine, and NCI compound NSC158011, whereas the yeasts carrying mutant PkPMT genes are unable to carry out phosphatidylcholine biosynthesis from phosphoethanolamine. xref Disruption of phosphatidylcholine synthesis in Plasmodium would lead to failure of intact Plasmodium membrane formation and thus inhibit parasite proliferation."
Amodiaquine affects digestion
| 1
Amodiaquine inhibits digestion. 1 / 1
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sparser
"It is suggested that whereas chloroquine and amodiaquine inhibit the digestion of hemoglobin, mefloquine and possibly quinine inhibit the ingestion of host cell hemoglobin by interfering with the ingestion process."
Amodiaquine affects defective neurotransmitter release synapse patient-derived neurons
| 1
Amodiaquine activates defective neurotransmitter release synapse patient-derived neurons. 1 / 1
| 1
eidos
"Amodiaquine and thiethylperazine also restored the defective neurotransmitter release at the synapse of patient-derived neurons ."
| 1
reach
"Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo."
| 1
reach
"Chloroquine and amodiaquine also reduce the expression of apoptotic (Bax and Cyt."
| 1
reach
"Another antimalarial agent, amodiaquine, at a con- centration of 0.1 mM did reduce ST (550 units/ml) activation of guanylate cyclase by 44 +/- 2%."
| 1
reach
"Each group was designated to be treated with a specific drug or drug combination (e.g., group A was treated with Amodiaquine alone and group B was treated with Ciprofloxacin alone while group C was treated with combinations of Amodiaquine and ciprofloxacin)."
Amodiaquine affects cholinesterases
| 1
Amodiaquine activates cholinesterases. 1 / 1
| 1
reach
"Slow and partial reactivation of sarin-, cyclosarin- and VX inhibited cholinesterases by amodiaquine was recorded, amodiaquine failed to reactivate tabun inhibited human cholinesterases."
| 1
reach
"Co-administration of artesunate and amodiaquine significantly reduced (P < 0.05) total cholesterol and HDL-cholesterol concentrations in the serum while significantly increasing (P < 0.05) serum LDL-cholesterol concentration, atherogenic index (LDL-C and HDL-C) and ACP activity in the heart compared to controls."
Amodiaquine affects cellular entry LF
| 1
Amodiaquine inhibits cellular entry LF. 1 / 1
| 1
eidos
"Amodiaquine inhibits cellular entry of LF ."
| 1
reach
"Anti-inflammatory activity of chloroquine and amodiaquine through p21 mediated suppression of T cell proliferation and Th1 cell differentiation."
Amodiaquine affects butyrylcholinesterase
| 1
Amodiaquine inhibits butyrylcholinesterase. 1 / 1
| 1
reach
"The characteristics of the inhibition of electric eel acetylcholinesterase (AChE) and horse serum butyrylcholinesterase (BChE) by the antimalarial agents mefloquine, chloroquine, amodiaquine and amopyroquine were determined."
Amodiaquine affects beta-haematin
| 1
Amodiaquine inhibits beta-haematin. 1 / 1
| 1
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"Artemisinin, quinine, primaquine and pyrimethamine activated beta-haematin phagocytosis by 12% or more, whereas amodiaquine, chloroquine and doxycyline inhibited beta-haematin phagocytosis."
| 1
reach
"Artesunate and DHA are known to have wide interpatient variability in their pharmacokinetic parameters, and artesunate and DHA exposure are both decreased by the co-administration of amodiaquine [XREF_BIBR]."
| 1
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"Chloroquine and amodiaquine reduce mitochondrial ROS production and apoptosis in RPTCs in a high-glucose environment."
Amodiaquine affects activities
| 1
Amodiaquine activates activities. 1 / 1
| 1
sparser
"Amodiaquine selectively activated the transcriptional activities of PPARα/γ, and enhanced both fatty acid oxidation and glucose uptake without altering insulin secretion in vitro."
Amodiaquine affects accumulation
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Amodiaquine inhibits accumulation. 1 / 1
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sparser
"Amodiaquine competitively inhibits chloroquine accumulation, and vice versa , suggesting that these compounds share a similar mechanism of accumulation (Fitch, 1973) ."
| 1
eidos
"In 1 in vitro study , 27 amodiaquine was shown to inhibit the Ebola virus as well the Marburg virus more potently than chloroquine , as demonstrated with lower EC 50 values ."
Amodiaquine affects TOM20
| 1
Amodiaquine decreases the amount of TOM20. 1 / 1
| 1
reach
"The siRNA for AMPK significantly inhibited chloroquine- or amodiaquine mediated enhancement of TOM20 expression in hRPTCs subject to high glucose environment."
Amodiaquine affects TNF
| 1
| 1
reach
"Amodiaquine partially suppressed increases of tumor necrosis factor (TNF)-alpha in the serum and TNF-alpha mRNA expression in the liver, whereas the expression of interleukin (IL)-18, interferon (IFN)-gamma and IL-12 in the liver was not changed by amodiaquine treatment."
Amodiaquine affects SP
| 1
Amodiaquine activates SP. 1 / 1
| 1
reach
"Adequate clinical response was observed in 88.5% of patients treated with chloroquine, 100% of patients treated with SP and 94.1% of patients treated with amodiaquine."
Amodiaquine affects SDHA
| 1
| 1
reach
"We have subsequently demonstrated that chloroquine and amodiaquine inhibit the degradation of FP by glutathione, resulting in the accumulation of FP in the membrane fraction of drug treated infected erythrocytes [17]."
Amodiaquine affects QPCT
| 1
| 1
reach
"Additionally, amodiaquine (AQ) inhibited DENV2 infectivity with EC 50 and EC 90 values of 1.08 +/-0.09 muM and 2.69 +/-0.47 muM, respectively, and inhibited viral RNA replication with an EC 50 value of 7.41 +/-1.09 muM in the replicon expressing cells [XREF_BIBR]."
Amodiaquine affects PkPMTs enzyme
| 1
Amodiaquine inhibits PkPMTs enzyme. 1 / 1
| 1
reach
"PkPMTs enzyme activity could be inhibited by amodiaquine, chloroquine, and NCI compound NSC158011, whereas the yeasts carrying mutant PkPMT genes are unable to carry out phosphatidylcholine biosynthesis from phosphoethanolamine."
Amodiaquine affects PPARA
| 1
| 1
reach
"Amodiaquine selectively activated the transcriptional activities of PPARalpha and gamma, and enhanced both fatty acid oxidation and glucose uptake without altering insulin secretion in vitro."
Amodiaquine affects PLD
| 1
| 1
reach
"In the present study, we have shown that Ca 2+ stimulated PLD activity of intestinal mitochondria was inhibited by both chloroquine and amodiaquine and these drugs had no significant effect on oxidant or polyamine stimulated PLD activity."
Amodiaquine affects NR4A2
| 1
| 1
reach
"In particular, we found that two antimalarial drugs, amodiaquine and chloroquine stimulate the transcriptional function of Nurr1 through physical interaction with its ligand binding domain (LBD)."
Amodiaquine affects MFN1
| 1
Amodiaquine increases the amount of MFN1. 1 / 1
| 1
reach
"Figure XREF_FIG shows that chloroquine and amodiaquine successfully restored Drp1 and Mfn1 expression, resulting in the normalization of Mfn1-to-Drp1 expression ratio in diabetic kidneys."
Amodiaquine affects LDL-cholesterol
| 1
Amodiaquine inhibits LDL-cholesterol. 1 / 1
| 1
reach
"Co-administration of artesunate and amodiaquine significantly reduced (P < 0.05) total cholesterol and HDL-cholesterol concentrations in the serum while significantly increasing (P < 0.05) serum LDL-cholesterol concentration, atherogenic index (LDL-C and HDL-C) and ACP activity in the heart compared to controls."
| 1
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"In conclusion, amodiaquine increased TLA and exploration, while simultaneously reducing anxiety in Wistar rats and these were dose dependent."
Amodiaquine affects INS
| 1
| 1
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"The other antimalarials tested, chloroquine, amodiaquine, mefloquine, and halofantrine, did not stimulate the release of insulin, an important advantage that should be taken into account when treatment is chosen for Plasmodium falciparum malaria."
| 1
sparser
"Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity HHS Public Access."
| 1
reach
"It is suggested that whereas chloroquine and amodiaquine inhibit the digestion of hemoglobin, mefloquine and possibly quinine inhibit the ingestion of host cell hemoglobin by interfering with the ingestion process."
Amodiaquine affects HDL-cholesterol
| 1
Amodiaquine inhibits HDL-cholesterol. 1 / 1
| 1
reach
"Co-administration of artesunate and amodiaquine significantly reduced (P < 0.05) total cholesterol and HDL-cholesterol concentrations in the serum while significantly increasing (P < 0.05) serum LDL-cholesterol concentration, atherogenic index (LDL-C and HDL-C) and ACP activity in the heart compared to controls."
Amodiaquine affects DNM1L
| 1
Amodiaquine increases the amount of DNM1L. 1 / 1
| 1
reach
"Figure XREF_FIG shows that chloroquine and amodiaquine successfully restored Drp1 and Mfn1 expression, resulting in the normalization of Mfn1-to-Drp1 expression ratio in diabetic kidneys."
Amodiaquine affects DHA-PQP
| 1
Amodiaquine activates DHA-PQP. 1 / 1
| 1
reach
"The frequency of adverse events was significantly lower in patients treated with DHA-PQP than in those treated with combinations containing amodiaquine."
Amodiaquine affects DENV2 infectivity values
| 1
Amodiaquine inhibits DENV2 infectivity values. 1 / 1
| 1
eidos
"Additionally , amodiaquine ( AQ ) inhibited DENV2 infectivity with EC 50 and EC 90 values of 1.08 + / - 0.09 muM and 2.69 + / - 0.47 muM , respectively , and inhibited viral RNA replication with an EC 50 value of 7.41 + / - 1.09 muM in the replicon-expressing cells [ 8] ."
Amodiaquine affects DENV-4
| 1
Amodiaquine inhibits DENV-4. 1 / 1
| 1
reach
"Amodiaquine reduced DENV-2 replication assay, and inhibited DENV-2, DENV-4, and WNV replication but with rather poor selectivity 257."
Amodiaquine affects DENV-2
| 1
Amodiaquine inhibits DENV-2. 1 / 1
| 1
reach
"Amodiaquine reduced DENV-2 replication assay, and inhibited DENV-2, DENV-4, and WNV replication but with rather poor selectivity 257."
Amodiaquine affects CHIV Junin JUNV viruses
| 1
Amodiaquine inhibits CHIV Junin JUNV viruses. 1 / 1
| 1
eidos
"Supplemental Tables : Amodiaquine and its metabolite inhibits Chikungunya ( CHIV ) and Junin ( JUNV ) viruses in host cells ."
Amodiaquine affects BKO mice
| 1
Amodiaquine inhibits BKO mice. 1 / 1
| 1
eidos
"Then , mice brains were sampled and analyzed to quantify levels of GM1 ganglioside ; AF488-CTB staining revealed that both amodiaquine and thiethylperazine treatments could reduce the signal of GM1 ganglioside in the BKO mice compared with the controls ( Figures 5A andS5A ) ."
Amodiaquine affects BCL2
| 1
Amodiaquine increases the amount of BCL2. 1 / 1
| 1
reach
"In addition, chloroquine and amodiaquine increased the expression of the antiapoptotic Bcl-2, resulting in a low Bcl-2-to-Bax expression ratio in RPTCs cultured under high-glucose conditions."
Amodiaquine affects BAX
| 1
| 1
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"Chloroquine and amodiaquine also reduce the expression of apoptotic (Bax and Cyt."
Amodiaquine affects AKAP4
| 1
| 1
reach
"Metoprine and, to much lesser degree, amodiaquine, but not aminoguanidine, slowed down the disappearance of exogenous HI from the rat brain."
| 1
reach
"Gametocy- taemia in Senegalese children with uncomplicated falcipar- um malaria treated with chloroquine, amodiaquine or sulfadoxine + pyrimethamine."
Amodiaquine affects TP53
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No evidence text available
Amodiaquine affects TGFB1
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Amodiaquine increases the amount of TGFB1. 1 / 1
1 |
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No evidence text available
Amodiaquine affects PLASMODIUM FALCIPARUM BLOOD INFECTION LEVEL
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Amodiaquine inhibits PLASMODIUM FALCIPARUM BLOOD INFECTION LEVEL. 1 / 1
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No evidence text available
Amodiaquine affects PDCD1
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Amodiaquine increases the amount of PDCD1. 1 / 1
1 |
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No evidence text available
Amodiaquine affects MCL1
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Amodiaquine decreases the amount of MCL1. 1 / 1
1 |
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No evidence text available
Amodiaquine affects MAPK8
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Amodiaquine phosphorylates MAPK8. 1 / 1
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No evidence text available
Amodiaquine affects MAPK3
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Amodiaquine phosphorylates MAPK3. 1 / 1
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No evidence text available
Amodiaquine affects MAPK1
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Amodiaquine phosphorylates MAPK1. 1 / 1
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No evidence text available
Amodiaquine affects LY6G
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Amodiaquine increases the amount of LY6G. 1 / 1
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ctd
No evidence text available
Amodiaquine affects LY6C1
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Amodiaquine increases the amount of LY6C1. 1 / 1
1 |
ctd
No evidence text available
Amodiaquine affects LAG3
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Amodiaquine increases the amount of LAG3. 1 / 1
1 |
ctd
No evidence text available
Amodiaquine affects GPT
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Amodiaquine increases the amount of GPT. 1 / 1
1 |
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No evidence text available
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No evidence text available
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Amodiaquine increases the amount of CYP3A7. 1 / 1
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No evidence text available
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Amodiaquine increases the amount of CYP3A5. 1 / 1
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No evidence text available
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Amodiaquine increases the amount of CYP2E1. 1 / 1
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No evidence text available
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Amodiaquine increases the amount of CYP2C18. 1 / 1
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No evidence text available
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Amodiaquine increases the amount of CYP2B6. 1 / 1
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No evidence text available
1 |
Amodiaquine increases the amount of CYP2A6. 1 / 1
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No evidence text available
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Amodiaquine increases the amount of CYP2A13. 1 / 1
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No evidence text available
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Amodiaquine increases the amount of CYP1B1. 1 / 1
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No evidence text available
Amodiaquine affects CTSL
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1 |
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No evidence text available
Amodiaquine affects CTSD
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1 |
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No evidence text available
Amodiaquine affects CTSB
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No evidence text available
Amodiaquine affects CTLA4
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Amodiaquine increases the amount of CTLA4. 1 / 1
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No evidence text available
Amodiaquine affects BCL2
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Amodiaquine decreases the amount of BCL2. 1 / 1
1 |
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No evidence text available
Amodiaquine affects BCHE
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1 |
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No evidence text available
Amodiaquine affects BAX
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Amodiaquine increases the amount of BAX. 1 / 1
1 |
ctd
No evidence text available